3K5KA

Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a potent inhibitor of histone lysine methyltransferase, g9a
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
274
structure length
272
Chain Sequence
RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
publication title Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 75
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3k5kA00
1MVXA 5EX0A 4FMUA 5CCLA 5JJ0A 1N3JA 3CBMA 3HNAA 4AU7A 4J7FA 3TG4A 1MT6A 3M59A 1O9SA 3MEKA 4MI5A 5TH7A 4JLGA 3K5KA 1ZKKA 4YPAA 3RQ4A 3DB5A 3KMTA 3M57A 4MI0A 3CBPA 5JHNA 3KMJA 3S7DA 2W5ZA 3VUZA 3M58A 3RU0A 4QENA 1MUFA 4YPEA 4C1QA 5LSXA 3RIBA 4JDSA 3TG5A 2RFIA 4BUPA 4E47A 4QEOA 5CCMA 2W5YA 1MVHA 3RJWA 5HQ8A 4WUYA 2JV0A 3OXFA 4YNMA 4NVQA 2G46A 3QWPA 5HI7A 5F59A 5KJLA 3SWCA 3N71A 4LDGA 2R3AA 3OOIA 3MO0A 5F6LA 4H12A 3EP0A 5KJNA 1H3IA 5KJMA 3CBOA 3SW9A 1N6CA 5EG2A 4YNDA 4J83A 4I51A 3BO5A 3MO2A 1PEGA 3S8PA 3VV0A 5JINA 4Z4PA 3KMAA 3S7BA 5JIYA 4YNPA 5T5GA 3FPDA 3M5AA 5F6KC 5CPRB 3DALA 5LSZA 4J8OA 4RZ0A 3S7JA 4QEPA 1XQHA 5TTFA 2IGQA 5T0MA 3M54A 3RAYA 4NJ5A 3PDNA 3OS5A 2QPWA 3OXLA 5ARGA 4J7IA 4IJ8A 3M55A 3OXGA 2BQZA 3QWWA 5TEGA 4O6FA 3OPEA 5EX3A 4IJDA 1ML9A 3F9WA 5KJKA 5ARFA 3M53A 3IHXA 5AYFA 5T0KA 3F9ZA 4YPUA 3QWVA 2O8JA 3M56A 4O30A 3F9XA 2F69A 3S7FA 1N6AA 3MO5A 5F5EA 3F9YA
chains in the Genus database with same CATH superfamily
1MVXA 5EX0A 4FMUA 5CCLA 5JJ0A 1N3JA 3CBMA 3HNAA 4AU7A 4J7FA 3TG4A 1MT6A 3M59A 1O9SA 3MEKA 4MI5A 5TH7A 4JLGA 3K5KA 1ZKKA 4YPAA 3RQ4A 3DB5A 3KMTA 3M57A 4MI0A 3CBPA 5JHNA 3KMJA 3S7DA 2W5ZA 3VUZA 3M58A 3RU0A 4QENA 1MUFA 4YPEA 4C1QA 5LSXA 3RIBA 4JDSA 3TG5A 2RFIA 4BUPA 4E47A 4QEOA 5CCMA 2W5YA 1MVHA 3RJWA 5HQ8A 4WUYA 2JV0A 3OXFA 4YNMA 4NVQA 2G46A 3QWPA 5HI7A 5F59A 5KJLA 3SWCA 3N71A 4LDGA 2R3AA 3OOIA 3MO0A 5F6LA 4H12A 3EP0A 5KJNA 1H3IA 5KJMA 3CBOA 3SW9A 1N6CA 5EG2A 4YNDA 4J83A 4I51A 3BO5A 3MO2A 1PEGA 3S8PA 3VV0A 5JINA 4Z4PA 3KMAA 3S7BA 5JIYA 4YNPA 5T5GA 3FPDA 3M5AA 5F6KC 5CPRB 3DALA 5LSZA 4J8OA 4RZ0A 3S7JA 4QEPA 1XQHA 5TTFA 2IGQA 5T0MA 3M54A 3RAYA 4NJ5A 3PDNA 3OS5A 2QPWA 3OXLA 5ARGA 4J7IA 4IJ8A 3M55A 3OXGA 2BQZA 3QWWA 5TEGA 4O6FA 3OPEA 5EX3A 4IJDA 1ML9A 3F9WA 5KJKA 5ARFA 3M53A 3IHXA 5AYFA 5T0KA 3F9ZA 4YPUA 3QWVA 2O8JA 3M56A 4O30A 3F9XA 2F69A 3S7FA 1N6AA 3MO5A 5F5EA 3F9YA
chains in the Genus database with same CATH topology
1MVXA 5EX0A 4FMUA 5CCLA 5JJ0A 1N3JA 3CBMA 3HNAA 4AU7A 4J7FA 3TG4A 1MT6A 3M59A 1O9SA 3MEKA 4MI5A 5TH7A 4JLGA 3K5KA 1ZKKA 4YPAA 3RQ4A 3DB5A 3KMTA 3M57A 4MI0A 3CBPA 5JHNA 3KMJA 3S7DA 2W5ZA 3VUZA 3M58A 3RU0A 4QENA 1MUFA 4YPEA 4C1QA 5LSXA 3RIBA 4JDSA 3TG5A 2RFIA 4BUPA 4E47A 4QEOA 5CCMA 2W5YA 1MVHA 3RJWA 5HQ8A 4WUYA 2JV0A 3OXFA 4YNMA 4NVQA 2G46A 3QWPA 5HI7A 5F59A 5KJLA 3SWCA 3N71A 4LDGA 2R3AA 3OOIA 3MO0A 5F6LA 4H12A 3EP0A 5KJNA 1H3IA 5KJMA 3CBOA 3SW9A 1N6CA 5EG2A 4YNDA 4J83A 4I51A 3BO5A 3MO2A 1PEGA 3S8PA 3VV0A 5JINA 4Z4PA 3KMAA 3S7BA 5JIYA 4YNPA 5T5GA 3FPDA 3M5AA 5F6KC 5CPRB 3DALA 5LSZA 4J8OA 4RZ0A 3S7JA 4QEPA 1XQHA 5TTFA 2IGQA 5T0MA 3M54A 3RAYA 4NJ5A 3PDNA 3OS5A 2QPWA 3OXLA 5ARGA 4J7IA 4IJ8A 3M55A 3OXGA 2BQZA 3QWWA 5TEGA 4O6FA 3OPEA 5EX3A 4IJDA 1ML9A 3F9WA 5KJKA 5ARFA 3M53A 3IHXA 5AYFA 5T0KA 3F9ZA 4YPUA 3QWVA 2O8JA 3M56A 4O30A 3F9XA 2F69A 3S7FA 1N6AA 3MO5A 5F5EA 3F9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MVX A;  5EX0 A;  4FMU A;  5CCL A;  5JJ0 A;  1N3J A;  3CBM A;  3HNA A;  4AU7 A;  4J7F A;  3TG4 A;  1MT6 A;  3M59 A;  1O9S A;  3MEK A;  4MI5 A;  5TH7 A;  4JLG A;  3K5K A;  1ZKK A;  4YPA A;  3RQ4 A;  3DB5 A;  3KMT A;  3M57 A;  4MI0 A;  3CBP A;  5JHN A;  3KMJ A;  3S7D A;  2W5Z A;  3VUZ A;  3M58 A;  3RU0 A;  4QEN A;  1MUF A;  4YPE A;  4C1Q A;  5LSX A;  3RIB A;  4JDS A;  3TG5 A;  2RFI A;  4BUP A;  4E47 A;  4QEO A;  5CCM A;  2W5Y A;  1MVH A;  3RJW A;  5HQ8 A;  4WUY A;  2JV0 A;  3OXF A;  4YNM A;  4NVQ A;  2G46 A;  3QWP A;  5HI7 A;  5F59 A;  5KJL A;  3SWC A;  3N71 A;  4LDG A;  2R3A A;  3OOI A;  3MO0 A;  5F6L A;  4H12 A;  3EP0 A;  5KJN A;  1H3I A;  5KJM A;  3CBO A;  3SW9 A;  1N6C A;  5EG2 A;  4YND A;  4J83 A;  4I51 A;  3BO5 A;  3MO2 A;  1PEG A;  3S8P A;  3VV0 A;  5JIN A;  4Z4P A;  3KMA A;  3S7B A;  5JIY A;  4YNP A;  5T5G A;  3FPD A;  3M5A A;  5F6K C;  5CPR B;  3DAL A;  5LSZ A;  4J8O A;  4RZ0 A;  3S7J A;  4QEP A;  1XQH A;  5TTF A;  2IGQ A;  5T0M A;  3M54 A;  3RAY A;  4NJ5 A;  3PDN A;  3OS5 A;  2QPW A;  3OXL A;  5ARG A;  4J7I A;  4IJ8 A;  3M55 A;  3OXG A;  2BQZ A;  3QWW A;  5TEG A;  4O6F A;  3OPE A;  5EX3 A;  4IJD A;  1ML9 A;  3F9W A;  5KJK A;  5ARF A;  3M53 A;  3IHX A;  5AYF A;  5T0K A;  3F9Z A;  4YPU A;  3QWV A;  2O8J A;  3M56 A;  4O30 A;  3F9X A;  2F69 A;  3S7F A;  1N6A A;  3MO5 A;  5F5E A;  3F9Y A; 
#chains in the Genus database with same CATH topology
 1MVX A;  5EX0 A;  4FMU A;  5CCL A;  5JJ0 A;  1N3J A;  3CBM A;  3HNA A;  4AU7 A;  4J7F A;  3TG4 A;  1MT6 A;  3M59 A;  1O9S A;  3MEK A;  4MI5 A;  5TH7 A;  4JLG A;  3K5K A;  1ZKK A;  4YPA A;  3RQ4 A;  3DB5 A;  3KMT A;  3M57 A;  4MI0 A;  3CBP A;  5JHN A;  3KMJ A;  3S7D A;  2W5Z A;  3VUZ A;  3M58 A;  3RU0 A;  4QEN A;  1MUF A;  4YPE A;  4C1Q A;  5LSX A;  3RIB A;  4JDS A;  3TG5 A;  2RFI A;  4BUP A;  4E47 A;  4QEO A;  5CCM A;  2W5Y A;  1MVH A;  3RJW A;  5HQ8 A;  4WUY A;  2JV0 A;  3OXF A;  4YNM A;  4NVQ A;  2G46 A;  3QWP A;  5HI7 A;  5F59 A;  5KJL A;  3SWC A;  3N71 A;  4LDG A;  2R3A A;  3OOI A;  3MO0 A;  5F6L A;  4H12 A;  3EP0 A;  5KJN A;  1H3I A;  5KJM A;  3CBO A;  3SW9 A;  1N6C A;  5EG2 A;  4YND A;  4J83 A;  4I51 A;  3BO5 A;  3MO2 A;  1PEG A;  3S8P A;  3VV0 A;  5JIN A;  4Z4P A;  3KMA A;  3S7B A;  5JIY A;  4YNP A;  5T5G A;  3FPD A;  3M5A A;  5F6K C;  5CPR B;  3DAL A;  5LSZ A;  4J8O A;  4RZ0 A;  3S7J A;  4QEP A;  1XQH A;  5TTF A;  2IGQ A;  5T0M A;  3M54 A;  3RAY A;  4NJ5 A;  3PDN A;  3OS5 A;  2QPW A;  3OXL A;  5ARG A;  4J7I A;  4IJ8 A;  3M55 A;  3OXG A;  2BQZ A;  3QWW A;  5TEG A;  4O6F A;  3OPE A;  5EX3 A;  4IJD A;  1ML9 A;  3F9W A;  5KJK A;  5ARF A;  3M53 A;  3IHX A;  5AYF A;  5T0K A;  3F9Z A;  4YPU A;  3QWV A;  2O8J A;  3M56 A;  4O30 A;  3F9X A;  2F69 A;  3S7F A;  1N6A A;  3MO5 A;  5F5E A;  3F9Y A; 
#chains in the Genus database with same CATH homology
 1MVX A;  5EX0 A;  4FMU A;  5CCL A;  5JJ0 A;  1N3J A;  3CBM A;  3HNA A;  4AU7 A;  4J7F A;  3TG4 A;  1MT6 A;  3M59 A;  1O9S A;  3MEK A;  4MI5 A;  5TH7 A;  4JLG A;  3K5K A;  1ZKK A;  4YPA A;  3RQ4 A;  3DB5 A;  3KMT A;  3M57 A;  4MI0 A;  3CBP A;  5JHN A;  3KMJ A;  3S7D A;  2W5Z A;  3VUZ A;  3M58 A;  3RU0 A;  4QEN A;  1MUF A;  4YPE A;  4C1Q A;  5LSX A;  3RIB A;  4JDS A;  3TG5 A;  2RFI A;  4BUP A;  4E47 A;  4QEO A;  5CCM A;  2W5Y A;  1MVH A;  3RJW A;  5HQ8 A;  4WUY A;  2JV0 A;  3OXF A;  4YNM A;  4NVQ A;  2G46 A;  3QWP A;  5HI7 A;  5F59 A;  5KJL A;  3SWC A;  3N71 A;  4LDG A;  2R3A A;  3OOI A;  3MO0 A;  5F6L A;  4H12 A;  3EP0 A;  5KJN A;  1H3I A;  5KJM A;  3CBO A;  3SW9 A;  1N6C A;  5EG2 A;  4YND A;  4J83 A;  4I51 A;  3BO5 A;  3MO2 A;  1PEG A;  3S8P A;  3VV0 A;  5JIN A;  4Z4P A;  3KMA A;  3S7B A;  5JIY A;  4YNP A;  5T5G A;  3FPD A;  3M5A A;  5F6K C;  5CPR B;  3DAL A;  5LSZ A;  4J8O A;  4RZ0 A;  3S7J A;  4QEP A;  1XQH A;  5TTF A;  2IGQ A;  5T0M A;  3M54 A;  3RAY A;  4NJ5 A;  3PDN A;  3OS5 A;  2QPW A;  3OXL A;  5ARG A;  4J7I A;  4IJ8 A;  3M55 A;  3OXG A;  2BQZ A;  3QWW A;  5TEG A;  4O6F A;  3OPE A;  5EX3 A;  4IJD A;  1ML9 A;  3F9W A;  5KJK A;  5ARF A;  3M53 A;  3IHX A;  5AYF A;  5T0K A;  3F9Z A;  4YPU A;  3QWV A;  2O8J A;  3M56 A;  4O30 A;  3F9X A;  2F69 A;  3S7F A;  1N6A A;  3MO5 A;  5F5E A;  3F9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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