3K5KA

Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a potent inhibitor of histone lysine methyltransferase, g9a
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
274
structure length
272
Chain Sequence
RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
total genus 75
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3k5kA00
2JV0A 3QWVA 1MUFA 4C1QA 3M57A 3OS5A 5F6KC 1ML9A 4MI0A 4Z4PA 3SWCA 4IJ8A 5LSXA 2RFIA 3M53A 3S7FA 3DALA 3F9YA 2QPWA 3RJWA 4JDSA 3HNAA 5HI7A 1H3IA 4IJDA 3F9WA 4QENA 4H12A 1MVXA 3M55A 4J7FA 3MO5A 5T5GA 1ZKKA 4FMUA 1MVHA 5CPRB 3TG5A 3M59A 4J8OA 1N3JA 1O9SA 5HQ8A 4O30A 4JLGA 5TTFA 5KJNA 3M58A 4YNMA 3PDNA 3M5AA 5LSZA 3DB5A 4YPAA 3QWPA 3QWWA 3OXFA 3F9XA 1N6CA 4MI5A 5ARFA 4J83A 5F6LA 4LDGA 3MO0A 5EX0A 4WUYA 5CCLA 3S7BA 4QEPA 3KMAA 5KJKA 4AU7A 4RZ0A 3N71A 5EG2A 5T0MA 1XQHA 3F9ZA 3MO2A 4NJ5A 5F5EA 4QEOA 2W5ZA 3M56A 3RAYA 3OOIA 5TH7A 5AYFA 4I51A 4YNPA 5ARGA 5JIYA 2BQZA 4NVQA 4E47A 3BO5A 3CBMA 3FPDA 5TEGA 3RQ4A 5JINA 4YPEA 3VUZA 5KJMA 3RU0A 4YPUA 3VV0A 3S7JA 1PEGA 5EX3A 3OPEA 3CBOA 3KMJA 2O8JA 5T0KA 4YNDA 3OXLA 3S8PA 3TG4A 4BUPA 3CBPA 5KJLA 3KMTA 2IGQA 3MEKA 3K5KA 1MT6A 5F59A 4O6FA 5JJ0A 4J7IA 3IHXA 2R3AA 3OXGA 3EP0A 3M54A 3SW9A 5JHNA 3S7DA 2W5YA 1N6AA 2G46A 3RIBA 5CCMA 2F69A
chains in the Genus database with same CATH superfamily
2JV0A 3QWVA 1MUFA 4C1QA 3M57A 3OS5A 5F6KC 1ML9A 4MI0A 4Z4PA 3SWCA 4IJ8A 5LSXA 2RFIA 3M53A 3S7FA 3DALA 3F9YA 2QPWA 3RJWA 4JDSA 3HNAA 5HI7A 1H3IA 4IJDA 3F9WA 4QENA 4H12A 1MVXA 3M55A 4J7FA 3MO5A 5T5GA 1ZKKA 4FMUA 1MVHA 5CPRB 3TG5A 3M59A 4J8OA 1N3JA 1O9SA 5HQ8A 4O30A 4JLGA 5TTFA 5KJNA 3M58A 4YNMA 3PDNA 3M5AA 5LSZA 3DB5A 4YPAA 3QWPA 3QWWA 3OXFA 3F9XA 1N6CA 4MI5A 5ARFA 4J83A 5F6LA 4LDGA 3MO0A 5EX0A 4WUYA 5CCLA 3S7BA 4QEPA 3KMAA 5KJKA 4AU7A 4RZ0A 3N71A 5EG2A 5T0MA 1XQHA 3F9ZA 3MO2A 4NJ5A 5F5EA 4QEOA 2W5ZA 3M56A 3RAYA 3OOIA 5TH7A 5AYFA 4I51A 4YNPA 5ARGA 5JIYA 2BQZA 4NVQA 4E47A 3BO5A 3CBMA 3FPDA 5TEGA 3RQ4A 5JINA 4YPEA 3VUZA 5KJMA 3RU0A 4YPUA 3VV0A 3S7JA 1PEGA 5EX3A 3OPEA 3CBOA 3KMJA 2O8JA 5T0KA 4YNDA 3OXLA 3S8PA 3TG4A 4BUPA 3CBPA 5KJLA 3KMTA 2IGQA 3MEKA 3K5KA 1MT6A 5F59A 4O6FA 5JJ0A 4J7IA 3IHXA 2R3AA 3OXGA 3EP0A 3M54A 3SW9A 5JHNA 3S7DA 2W5YA 1N6AA 2G46A 3RIBA 5CCMA 2F69A
chains in the Genus database with same CATH topology
2JV0A 3QWVA 1MUFA 4C1QA 3M57A 3OS5A 5F6KC 1ML9A 4MI0A 4Z4PA 3SWCA 4IJ8A 5LSXA 2RFIA 3M53A 3S7FA 3DALA 3F9YA 2QPWA 3RJWA 4JDSA 3HNAA 5HI7A 1H3IA 4IJDA 3F9WA 4QENA 4H12A 1MVXA 3M55A 4J7FA 3MO5A 5T5GA 1ZKKA 4FMUA 1MVHA 5CPRB 3TG5A 3M59A 4J8OA 1N3JA 1O9SA 5HQ8A 4O30A 4JLGA 5TTFA 5KJNA 3M58A 4YNMA 3PDNA 3M5AA 5LSZA 3DB5A 4YPAA 3QWPA 3QWWA 3OXFA 3F9XA 1N6CA 4MI5A 5ARFA 4J83A 5F6LA 4LDGA 3MO0A 5EX0A 4WUYA 5CCLA 3S7BA 4QEPA 3KMAA 5KJKA 4AU7A 4RZ0A 3N71A 5EG2A 5T0MA 1XQHA 3F9ZA 3MO2A 4NJ5A 5F5EA 4QEOA 2W5ZA 3M56A 3RAYA 3OOIA 5TH7A 5AYFA 4I51A 4YNPA 5ARGA 5JIYA 2BQZA 4NVQA 4E47A 3BO5A 3CBMA 3FPDA 5TEGA 3RQ4A 5JINA 4YPEA 3VUZA 5KJMA 3RU0A 4YPUA 3VV0A 3S7JA 1PEGA 5EX3A 3OPEA 3CBOA 3KMJA 2O8JA 5T0KA 4YNDA 3OXLA 3S8PA 3TG4A 4BUPA 3CBPA 5KJLA 3KMTA 2IGQA 3MEKA 3K5KA 1MT6A 5F59A 4O6FA 5JJ0A 4J7IA 3IHXA 2R3AA 3OXGA 3EP0A 3M54A 3SW9A 5JHNA 3S7DA 2W5YA 1N6AA 2G46A 3RIBA 5CCMA 2F69A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JV0 A;  3QWV A;  1MUF A;  4C1Q A;  3M57 A;  3OS5 A;  5F6K C;  1ML9 A;  4MI0 A;  4Z4P A;  3SWC A;  4IJ8 A;  5LSX A;  2RFI A;  3M53 A;  3S7F A;  3DAL A;  3F9Y A;  2QPW A;  3RJW A;  4JDS A;  3HNA A;  5HI7 A;  1H3I A;  4IJD A;  3F9W A;  4QEN A;  4H12 A;  1MVX A;  3M55 A;  4J7F A;  3MO5 A;  5T5G A;  1ZKK A;  4FMU A;  1MVH A;  5CPR B;  3TG5 A;  3M59 A;  4J8O A;  1N3J A;  1O9S A;  5HQ8 A;  4O30 A;  4JLG A;  5TTF A;  5KJN A;  3M58 A;  4YNM A;  3PDN A;  3M5A A;  5LSZ A;  3DB5 A;  4YPA A;  3QWP A;  3QWW A;  3OXF A;  3F9X A;  1N6C A;  4MI5 A;  5ARF A;  4J83 A;  5F6L A;  4LDG A;  3MO0 A;  5EX0 A;  4WUY A;  5CCL A;  3S7B A;  4QEP A;  3KMA A;  5KJK A;  4AU7 A;  4RZ0 A;  3N71 A;  5EG2 A;  5T0M A;  1XQH A;  3F9Z A;  3MO2 A;  4NJ5 A;  5F5E A;  4QEO A;  2W5Z A;  3M56 A;  3RAY A;  3OOI A;  5TH7 A;  5AYF A;  4I51 A;  4YNP A;  5ARG A;  5JIY A;  2BQZ A;  4NVQ A;  4E47 A;  3BO5 A;  3CBM A;  3FPD A;  5TEG A;  3RQ4 A;  5JIN A;  4YPE A;  3VUZ A;  5KJM A;  3RU0 A;  4YPU A;  3VV0 A;  3S7J A;  1PEG A;  5EX3 A;  3OPE A;  3CBO A;  3KMJ A;  2O8J A;  5T0K A;  4YND A;  3OXL A;  3S8P A;  3TG4 A;  4BUP A;  3CBP A;  5KJL A;  3KMT A;  2IGQ A;  3MEK A;  3K5K A;  1MT6 A;  5F59 A;  4O6F A;  5JJ0 A;  4J7I A;  3IHX A;  2R3A A;  3OXG A;  3EP0 A;  3M54 A;  3SW9 A;  5JHN A;  3S7D A;  2W5Y A;  1N6A A;  2G46 A;  3RIB A;  5CCM A;  2F69 A; 
#chains in the Genus database with same CATH topology
 2JV0 A;  3QWV A;  1MUF A;  4C1Q A;  3M57 A;  3OS5 A;  5F6K C;  1ML9 A;  4MI0 A;  4Z4P A;  3SWC A;  4IJ8 A;  5LSX A;  2RFI A;  3M53 A;  3S7F A;  3DAL A;  3F9Y A;  2QPW A;  3RJW A;  4JDS A;  3HNA A;  5HI7 A;  1H3I A;  4IJD A;  3F9W A;  4QEN A;  4H12 A;  1MVX A;  3M55 A;  4J7F A;  3MO5 A;  5T5G A;  1ZKK A;  4FMU A;  1MVH A;  5CPR B;  3TG5 A;  3M59 A;  4J8O A;  1N3J A;  1O9S A;  5HQ8 A;  4O30 A;  4JLG A;  5TTF A;  5KJN A;  3M58 A;  4YNM A;  3PDN A;  3M5A A;  5LSZ A;  3DB5 A;  4YPA A;  3QWP A;  3QWW A;  3OXF A;  3F9X A;  1N6C A;  4MI5 A;  5ARF A;  4J83 A;  5F6L A;  4LDG A;  3MO0 A;  5EX0 A;  4WUY A;  5CCL A;  3S7B A;  4QEP A;  3KMA A;  5KJK A;  4AU7 A;  4RZ0 A;  3N71 A;  5EG2 A;  5T0M A;  1XQH A;  3F9Z A;  3MO2 A;  4NJ5 A;  5F5E A;  4QEO A;  2W5Z A;  3M56 A;  3RAY A;  3OOI A;  5TH7 A;  5AYF A;  4I51 A;  4YNP A;  5ARG A;  5JIY A;  2BQZ A;  4NVQ A;  4E47 A;  3BO5 A;  3CBM A;  3FPD A;  5TEG A;  3RQ4 A;  5JIN A;  4YPE A;  3VUZ A;  5KJM A;  3RU0 A;  4YPU A;  3VV0 A;  3S7J A;  1PEG A;  5EX3 A;  3OPE A;  3CBO A;  3KMJ A;  2O8J A;  5T0K A;  4YND A;  3OXL A;  3S8P A;  3TG4 A;  4BUP A;  3CBP A;  5KJL A;  3KMT A;  2IGQ A;  3MEK A;  3K5K A;  1MT6 A;  5F59 A;  4O6F A;  5JJ0 A;  4J7I A;  3IHX A;  2R3A A;  3OXG A;  3EP0 A;  3M54 A;  3SW9 A;  5JHN A;  3S7D A;  2W5Y A;  1N6A A;  2G46 A;  3RIB A;  5CCM A;  2F69 A; 
#chains in the Genus database with same CATH homology
 2JV0 A;  3QWV A;  1MUF A;  4C1Q A;  3M57 A;  3OS5 A;  5F6K C;  1ML9 A;  4MI0 A;  4Z4P A;  3SWC A;  4IJ8 A;  5LSX A;  2RFI A;  3M53 A;  3S7F A;  3DAL A;  3F9Y A;  2QPW A;  3RJW A;  4JDS A;  3HNA A;  5HI7 A;  1H3I A;  4IJD A;  3F9W A;  4QEN A;  4H12 A;  1MVX A;  3M55 A;  4J7F A;  3MO5 A;  5T5G A;  1ZKK A;  4FMU A;  1MVH A;  5CPR B;  3TG5 A;  3M59 A;  4J8O A;  1N3J A;  1O9S A;  5HQ8 A;  4O30 A;  4JLG A;  5TTF A;  5KJN A;  3M58 A;  4YNM A;  3PDN A;  3M5A A;  5LSZ A;  3DB5 A;  4YPA A;  3QWP A;  3QWW A;  3OXF A;  3F9X A;  1N6C A;  4MI5 A;  5ARF A;  4J83 A;  5F6L A;  4LDG A;  3MO0 A;  5EX0 A;  4WUY A;  5CCL A;  3S7B A;  4QEP A;  3KMA A;  5KJK A;  4AU7 A;  4RZ0 A;  3N71 A;  5EG2 A;  5T0M A;  1XQH A;  3F9Z A;  3MO2 A;  4NJ5 A;  5F5E A;  4QEO A;  2W5Z A;  3M56 A;  3RAY A;  3OOI A;  5TH7 A;  5AYF A;  4I51 A;  4YNP A;  5ARG A;  5JIY A;  2BQZ A;  4NVQ A;  4E47 A;  3BO5 A;  3CBM A;  3FPD A;  5TEG A;  3RQ4 A;  5JIN A;  4YPE A;  3VUZ A;  5KJM A;  3RU0 A;  4YPU A;  3VV0 A;  3S7J A;  1PEG A;  5EX3 A;  3OPE A;  3CBO A;  3KMJ A;  2O8J A;  5T0K A;  4YND A;  3OXL A;  3S8P A;  3TG4 A;  4BUP A;  3CBP A;  5KJL A;  3KMT A;  2IGQ A;  3MEK A;  3K5K A;  1MT6 A;  5F59 A;  4O6F A;  5JJ0 A;  4J7I A;  3IHX A;  2R3A A;  3OXG A;  3EP0 A;  3M54 A;  3SW9 A;  5JHN A;  3S7D A;  2W5Y A;  1N6A A;  2G46 A;  3RIB A;  5CCM A;  2F69 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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