3K5KA

Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a potent inhibitor of histone lysine methyltransferase, g9a
Total Genus 75
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
274
structure length
272
Chain Sequence
RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
publication title Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
pubmed doi rcsb
source organism Homo sapiens
total genus 75
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3k5kA00
3M5AA 3M57A 4YPAA 3PDNA 3OPEA 4YPEA 1H3IA 1MT6A 3S7DA 1MVHA 1MVXA 2F69A 3N71A 4QEPA 4J7IA 4NVQA 3S7BA 5EX0A 5T0MA 4J7FA 5JJ0A 2IGQA 5HI7A 3TG5A 1O9SA 4Z4PA 3CBMA 3M59A 4WUYA 3MO0A 3RQ4A 5KJMA 3SWCA 5F59A 2O8JA 1XQHA 4I51A 4J83A 5KJLA 2W5ZA 2QPWA 3RJWA 3SW9A 3M55A 5ARGA 1N6CA 5JHNA 5JINA 3RAYA 3F9ZA 3QWWA 3TG4A 1N3JA 2BQZA 3KMAA 4YNPA 5CCLA 3OXLA 2JV0A 4IJDA 4JDSA 5TH7A 2G46A 4QENA 5HQ8A 5F6KC 5KJNA 4NJ5A 3CBPA 3HNAA 5F5EA 5ARFA 3QWVA 5CCMA 5EX3A 4YNMA 3KMTA 3EP0A 3S7JA 4O6FA 4JLGA 3DB5A 3OXFA 3M56A 3RIBA 3S7FA 4IJ8A 3F9YA 3M54A 3MEKA 4J8OA 3OS5A 4YNDA 4QEOA 3S8PA 5KJKA 3F9XA 1MUFA 4O30A 1N6AA 3MO5A 2W5YA 5LSZA 1ZKKA 3K5KA 3QWPA 4H12A 2R3AA 5EG2A 3BO5A 3MO2A 5F6LA 3IHXA 3M53A 1ML9A 4RZ0A 4C1QA 3FPDA 5JIYA 3F9WA 3CBOA 4BUPA 3OXGA 3RU0A 3DALA 4YPUA 4LDGA 5LSXA 5TEGA 2RFIA 4MI0A 3VV0A 4E47A 3VUZA 5T0KA 3OOIA 4FMUA 3M58A 5T5GA 5CPRB 5TTFA 4AU7A 1PEGA 3KMJA 5AYFA 4MI5A
chains in the Genus database with same CATH superfamily
3M5AA 3M57A 4YPAA 3PDNA 3OPEA 4YPEA 1H3IA 1MT6A 3S7DA 1MVHA 1MVXA 2F69A 3N71A 4QEPA 4J7IA 4NVQA 3S7BA 5EX0A 5T0MA 4J7FA 5JJ0A 2IGQA 5HI7A 3TG5A 1O9SA 4Z4PA 3CBMA 3M59A 4WUYA 3MO0A 3RQ4A 5KJMA 3SWCA 5F59A 2O8JA 1XQHA 4I51A 4J83A 5KJLA 2W5ZA 2QPWA 3RJWA 3SW9A 3M55A 5ARGA 1N6CA 5JHNA 5JINA 3RAYA 3F9ZA 3QWWA 3TG4A 1N3JA 2BQZA 3KMAA 4YNPA 5CCLA 3OXLA 2JV0A 4IJDA 4JDSA 5TH7A 2G46A 4QENA 5HQ8A 5F6KC 5KJNA 4NJ5A 3CBPA 3HNAA 5F5EA 5ARFA 3QWVA 5CCMA 5EX3A 4YNMA 3KMTA 3EP0A 3S7JA 4O6FA 4JLGA 3DB5A 3OXFA 3M56A 3RIBA 3S7FA 4IJ8A 3F9YA 3M54A 3MEKA 4J8OA 3OS5A 4YNDA 4QEOA 3S8PA 5KJKA 3F9XA 1MUFA 4O30A 1N6AA 3MO5A 2W5YA 5LSZA 1ZKKA 3K5KA 3QWPA 4H12A 2R3AA 5EG2A 3BO5A 3MO2A 5F6LA 3IHXA 3M53A 1ML9A 4RZ0A 4C1QA 3FPDA 5JIYA 3F9WA 3CBOA 4BUPA 3OXGA 3RU0A 3DALA 4YPUA 4LDGA 5LSXA 5TEGA 2RFIA 4MI0A 3VV0A 4E47A 3VUZA 5T0KA 3OOIA 4FMUA 3M58A 5T5GA 5CPRB 5TTFA 4AU7A 1PEGA 3KMJA 5AYFA 4MI5A
chains in the Genus database with same CATH topology
3M5AA 3M57A 4YPAA 3PDNA 3OPEA 4YPEA 1H3IA 1MT6A 3S7DA 1MVHA 1MVXA 2F69A 3N71A 4QEPA 4J7IA 4NVQA 3S7BA 5EX0A 5T0MA 4J7FA 5JJ0A 2IGQA 5HI7A 3TG5A 1O9SA 4Z4PA 3CBMA 3M59A 4WUYA 3MO0A 3RQ4A 5KJMA 3SWCA 5F59A 2O8JA 1XQHA 4I51A 4J83A 5KJLA 2W5ZA 2QPWA 3RJWA 3SW9A 3M55A 5ARGA 1N6CA 5JHNA 5JINA 3RAYA 3F9ZA 3QWWA 3TG4A 1N3JA 2BQZA 3KMAA 4YNPA 5CCLA 3OXLA 2JV0A 4IJDA 4JDSA 5TH7A 2G46A 4QENA 5HQ8A 5F6KC 5KJNA 4NJ5A 3CBPA 3HNAA 5F5EA 5ARFA 3QWVA 5CCMA 5EX3A 4YNMA 3KMTA 3EP0A 3S7JA 4O6FA 4JLGA 3DB5A 3OXFA 3M56A 3RIBA 3S7FA 4IJ8A 3F9YA 3M54A 3MEKA 4J8OA 3OS5A 4YNDA 4QEOA 3S8PA 5KJKA 3F9XA 1MUFA 4O30A 1N6AA 3MO5A 2W5YA 5LSZA 1ZKKA 3K5KA 3QWPA 4H12A 2R3AA 5EG2A 3BO5A 3MO2A 5F6LA 3IHXA 3M53A 1ML9A 4RZ0A 4C1QA 3FPDA 5JIYA 3F9WA 3CBOA 4BUPA 3OXGA 3RU0A 3DALA 4YPUA 4LDGA 5LSXA 5TEGA 2RFIA 4MI0A 3VV0A 4E47A 3VUZA 5T0KA 3OOIA 4FMUA 3M58A 5T5GA 5CPRB 5TTFA 4AU7A 1PEGA 3KMJA 5AYFA 4MI5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M5A A;  3M57 A;  4YPA A;  3PDN A;  3OPE A;  4YPE A;  1H3I A;  1MT6 A;  3S7D A;  1MVH A;  1MVX A;  2F69 A;  3N71 A;  4QEP A;  4J7I A;  4NVQ A;  3S7B A;  5EX0 A;  5T0M A;  4J7F A;  5JJ0 A;  2IGQ A;  5HI7 A;  3TG5 A;  1O9S A;  4Z4P A;  3CBM A;  3M59 A;  4WUY A;  3MO0 A;  3RQ4 A;  5KJM A;  3SWC A;  5F59 A;  2O8J A;  1XQH A;  4I51 A;  4J83 A;  5KJL A;  2W5Z A;  2QPW A;  3RJW A;  3SW9 A;  3M55 A;  5ARG A;  1N6C A;  5JHN A;  5JIN A;  3RAY A;  3F9Z A;  3QWW A;  3TG4 A;  1N3J A;  2BQZ A;  3KMA A;  4YNP A;  5CCL A;  3OXL A;  2JV0 A;  4IJD A;  4JDS A;  5TH7 A;  2G46 A;  4QEN A;  5HQ8 A;  5F6K C;  5KJN A;  4NJ5 A;  3CBP A;  3HNA A;  5F5E A;  5ARF A;  3QWV A;  5CCM A;  5EX3 A;  4YNM A;  3KMT A;  3EP0 A;  3S7J A;  4O6F A;  4JLG A;  3DB5 A;  3OXF A;  3M56 A;  3RIB A;  3S7F A;  4IJ8 A;  3F9Y A;  3M54 A;  3MEK A;  4J8O A;  3OS5 A;  4YND A;  4QEO A;  3S8P A;  5KJK A;  3F9X A;  1MUF A;  4O30 A;  1N6A A;  3MO5 A;  2W5Y A;  5LSZ A;  1ZKK A;  3K5K A;  3QWP A;  4H12 A;  2R3A A;  5EG2 A;  3BO5 A;  3MO2 A;  5F6L A;  3IHX A;  3M53 A;  1ML9 A;  4RZ0 A;  4C1Q A;  3FPD A;  5JIY A;  3F9W A;  3CBO A;  4BUP A;  3OXG A;  3RU0 A;  3DAL A;  4YPU A;  4LDG A;  5LSX A;  5TEG A;  2RFI A;  4MI0 A;  3VV0 A;  4E47 A;  3VUZ A;  5T0K A;  3OOI A;  4FMU A;  3M58 A;  5T5G A;  5CPR B;  5TTF A;  4AU7 A;  1PEG A;  3KMJ A;  5AYF A;  4MI5 A; 
#chains in the Genus database with same CATH topology
 3M5A A;  3M57 A;  4YPA A;  3PDN A;  3OPE A;  4YPE A;  1H3I A;  1MT6 A;  3S7D A;  1MVH A;  1MVX A;  2F69 A;  3N71 A;  4QEP A;  4J7I A;  4NVQ A;  3S7B A;  5EX0 A;  5T0M A;  4J7F A;  5JJ0 A;  2IGQ A;  5HI7 A;  3TG5 A;  1O9S A;  4Z4P A;  3CBM A;  3M59 A;  4WUY A;  3MO0 A;  3RQ4 A;  5KJM A;  3SWC A;  5F59 A;  2O8J A;  1XQH A;  4I51 A;  4J83 A;  5KJL A;  2W5Z A;  2QPW A;  3RJW A;  3SW9 A;  3M55 A;  5ARG A;  1N6C A;  5JHN A;  5JIN A;  3RAY A;  3F9Z A;  3QWW A;  3TG4 A;  1N3J A;  2BQZ A;  3KMA A;  4YNP A;  5CCL A;  3OXL A;  2JV0 A;  4IJD A;  4JDS A;  5TH7 A;  2G46 A;  4QEN A;  5HQ8 A;  5F6K C;  5KJN A;  4NJ5 A;  3CBP A;  3HNA A;  5F5E A;  5ARF A;  3QWV A;  5CCM A;  5EX3 A;  4YNM A;  3KMT A;  3EP0 A;  3S7J A;  4O6F A;  4JLG A;  3DB5 A;  3OXF A;  3M56 A;  3RIB A;  3S7F A;  4IJ8 A;  3F9Y A;  3M54 A;  3MEK A;  4J8O A;  3OS5 A;  4YND A;  4QEO A;  3S8P A;  5KJK A;  3F9X A;  1MUF A;  4O30 A;  1N6A A;  3MO5 A;  2W5Y A;  5LSZ A;  1ZKK A;  3K5K A;  3QWP A;  4H12 A;  2R3A A;  5EG2 A;  3BO5 A;  3MO2 A;  5F6L A;  3IHX A;  3M53 A;  1ML9 A;  4RZ0 A;  4C1Q A;  3FPD A;  5JIY A;  3F9W A;  3CBO A;  4BUP A;  3OXG A;  3RU0 A;  3DAL A;  4YPU A;  4LDG A;  5LSX A;  5TEG A;  2RFI A;  4MI0 A;  3VV0 A;  4E47 A;  3VUZ A;  5T0K A;  3OOI A;  4FMU A;  3M58 A;  5T5G A;  5CPR B;  5TTF A;  4AU7 A;  1PEG A;  3KMJ A;  5AYF A;  4MI5 A; 
#chains in the Genus database with same CATH homology
 3M5A A;  3M57 A;  4YPA A;  3PDN A;  3OPE A;  4YPE A;  1H3I A;  1MT6 A;  3S7D A;  1MVH A;  1MVX A;  2F69 A;  3N71 A;  4QEP A;  4J7I A;  4NVQ A;  3S7B A;  5EX0 A;  5T0M A;  4J7F A;  5JJ0 A;  2IGQ A;  5HI7 A;  3TG5 A;  1O9S A;  4Z4P A;  3CBM A;  3M59 A;  4WUY A;  3MO0 A;  3RQ4 A;  5KJM A;  3SWC A;  5F59 A;  2O8J A;  1XQH A;  4I51 A;  4J83 A;  5KJL A;  2W5Z A;  2QPW A;  3RJW A;  3SW9 A;  3M55 A;  5ARG A;  1N6C A;  5JHN A;  5JIN A;  3RAY A;  3F9Z A;  3QWW A;  3TG4 A;  1N3J A;  2BQZ A;  3KMA A;  4YNP A;  5CCL A;  3OXL A;  2JV0 A;  4IJD A;  4JDS A;  5TH7 A;  2G46 A;  4QEN A;  5HQ8 A;  5F6K C;  5KJN A;  4NJ5 A;  3CBP A;  3HNA A;  5F5E A;  5ARF A;  3QWV A;  5CCM A;  5EX3 A;  4YNM A;  3KMT A;  3EP0 A;  3S7J A;  4O6F A;  4JLG A;  3DB5 A;  3OXF A;  3M56 A;  3RIB A;  3S7F A;  4IJ8 A;  3F9Y A;  3M54 A;  3MEK A;  4J8O A;  3OS5 A;  4YND A;  4QEO A;  3S8P A;  5KJK A;  3F9X A;  1MUF A;  4O30 A;  1N6A A;  3MO5 A;  2W5Y A;  5LSZ A;  1ZKK A;  3K5K A;  3QWP A;  4H12 A;  2R3A A;  5EG2 A;  3BO5 A;  3MO2 A;  5F6L A;  3IHX A;  3M53 A;  1ML9 A;  4RZ0 A;  4C1Q A;  3FPD A;  5JIY A;  3F9W A;  3CBO A;  4BUP A;  3OXG A;  3RU0 A;  3DAL A;  4YPU A;  4LDG A;  5LSX A;  5TEG A;  2RFI A;  4MI0 A;  3VV0 A;  4E47 A;  3VUZ A;  5T0K A;  3OOI A;  4FMU A;  3M58 A;  5T5G A;  5CPR B;  5TTF A;  4AU7 A;  1PEG A;  3KMJ A;  5AYF A;  4MI5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...