3K5KA

Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a potent inhibitor of histone lysine methyltransferase, g9a
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
274
structure length
272
Chain Sequence
RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
publication title Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 75
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3k5kA00
4WUYA 3RQ4A 3EP0A 2R3AA 3F9WA 3VV0A 1ML9A 3KMTA 3M55A 2RFIA 3M59A 5T0MA 3SWCA 4Z4PA 2BQZA 4I51A 4RZ0A 5ARFA 3MO5A 4C1QA 3OS5A 4E47A 4QEPA 4YPAA 4YNMA 1N6AA 5CCLA 4JDSA 4YPUA 3S7FA 5KJNA 2F69A 4LDGA 3M53A 3S7JA 5T5GA 5KJMA 5AYFA 4J8OA 1MVXA 5JINA 4JLGA 5TTFA 5KJKA 4J7FA 5F59A 2JV0A 1N6CA 3RIBA 3F9XA 3M54A 5CCMA 4FMUA 3QWVA 3M57A 3CBPA 4NVQA 4BUPA 4H12A 3K5KA 4YNDA 2QPWA 5EX3A 4QENA 3OOIA 3MO2A 5F6LA 5HI7A 5KJLA 3BO5A 5LSZA 3RJWA 3RU0A 3F9YA 1MT6A 4IJ8A 4NJ5A 1XQHA 3DALA 3M5AA 5TH7A 5CPRB 4AU7A 3S7DA 3SW9A 3M56A 5ARGA 3S7BA 3VUZA 5F5EA 1N3JA 3FPDA 1PEGA 3QWPA 1MUFA 1O9SA 5T0KA 4YPEA 4YNPA 5JIYA 4MI5A 1H3IA 4J7IA 3OPEA 3TG5A 3QWWA 3KMJA 5JHNA 3KMAA 5LSXA 3RAYA 1ZKKA 4O30A 3S8PA 3M58A 3DB5A 3CBOA 3OXFA 5EX0A 4IJDA 3OXLA 5F6KC 5JJ0A 3N71A 2W5ZA 3OXGA 3CBMA 3F9ZA 2O8JA 5TEGA 3TG4A 3PDNA 4QEOA 5EG2A 2W5YA 4J83A 2G46A 3IHXA 5HQ8A 3HNAA 4MI0A 4O6FA 1MVHA 3MO0A 3MEKA 2IGQA
chains in the Genus database with same CATH superfamily
4WUYA 3RQ4A 3EP0A 2R3AA 3F9WA 3VV0A 1ML9A 3KMTA 3M55A 2RFIA 3M59A 5T0MA 3SWCA 4Z4PA 2BQZA 4I51A 4RZ0A 5ARFA 3MO5A 4C1QA 3OS5A 4E47A 4QEPA 4YPAA 4YNMA 1N6AA 5CCLA 4JDSA 4YPUA 3S7FA 5KJNA 2F69A 4LDGA 3M53A 3S7JA 5T5GA 5KJMA 5AYFA 4J8OA 1MVXA 5JINA 4JLGA 5TTFA 5KJKA 4J7FA 5F59A 2JV0A 1N6CA 3RIBA 3F9XA 3M54A 5CCMA 4FMUA 3QWVA 3M57A 3CBPA 4NVQA 4BUPA 4H12A 3K5KA 4YNDA 2QPWA 5EX3A 4QENA 3OOIA 3MO2A 5F6LA 5HI7A 5KJLA 3BO5A 5LSZA 3RJWA 3RU0A 3F9YA 1MT6A 4IJ8A 4NJ5A 1XQHA 3DALA 3M5AA 5TH7A 5CPRB 4AU7A 3S7DA 3SW9A 3M56A 5ARGA 3S7BA 3VUZA 5F5EA 1N3JA 3FPDA 1PEGA 3QWPA 1MUFA 1O9SA 5T0KA 4YPEA 4YNPA 5JIYA 4MI5A 1H3IA 4J7IA 3OPEA 3TG5A 3QWWA 3KMJA 5JHNA 3KMAA 5LSXA 3RAYA 1ZKKA 4O30A 3S8PA 3M58A 3DB5A 3CBOA 3OXFA 5EX0A 4IJDA 3OXLA 5F6KC 5JJ0A 3N71A 2W5ZA 3OXGA 3CBMA 3F9ZA 2O8JA 5TEGA 3TG4A 3PDNA 4QEOA 5EG2A 2W5YA 4J83A 2G46A 3IHXA 5HQ8A 3HNAA 4MI0A 4O6FA 1MVHA 3MO0A 3MEKA 2IGQA
chains in the Genus database with same CATH topology
4WUYA 3RQ4A 3EP0A 2R3AA 3F9WA 3VV0A 1ML9A 3KMTA 3M55A 2RFIA 3M59A 5T0MA 3SWCA 4Z4PA 2BQZA 4I51A 4RZ0A 5ARFA 3MO5A 4C1QA 3OS5A 4E47A 4QEPA 4YPAA 4YNMA 1N6AA 5CCLA 4JDSA 4YPUA 3S7FA 5KJNA 2F69A 4LDGA 3M53A 3S7JA 5T5GA 5KJMA 5AYFA 4J8OA 1MVXA 5JINA 4JLGA 5TTFA 5KJKA 4J7FA 5F59A 2JV0A 1N6CA 3RIBA 3F9XA 3M54A 5CCMA 4FMUA 3QWVA 3M57A 3CBPA 4NVQA 4BUPA 4H12A 3K5KA 4YNDA 2QPWA 5EX3A 4QENA 3OOIA 3MO2A 5F6LA 5HI7A 5KJLA 3BO5A 5LSZA 3RJWA 3RU0A 3F9YA 1MT6A 4IJ8A 4NJ5A 1XQHA 3DALA 3M5AA 5TH7A 5CPRB 4AU7A 3S7DA 3SW9A 3M56A 5ARGA 3S7BA 3VUZA 5F5EA 1N3JA 3FPDA 1PEGA 3QWPA 1MUFA 1O9SA 5T0KA 4YPEA 4YNPA 5JIYA 4MI5A 1H3IA 4J7IA 3OPEA 3TG5A 3QWWA 3KMJA 5JHNA 3KMAA 5LSXA 3RAYA 1ZKKA 4O30A 3S8PA 3M58A 3DB5A 3CBOA 3OXFA 5EX0A 4IJDA 3OXLA 5F6KC 5JJ0A 3N71A 2W5ZA 3OXGA 3CBMA 3F9ZA 2O8JA 5TEGA 3TG4A 3PDNA 4QEOA 5EG2A 2W5YA 4J83A 2G46A 3IHXA 5HQ8A 3HNAA 4MI0A 4O6FA 1MVHA 3MO0A 3MEKA 2IGQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WUY A;  3RQ4 A;  3EP0 A;  2R3A A;  3F9W A;  3VV0 A;  1ML9 A;  3KMT A;  3M55 A;  2RFI A;  3M59 A;  5T0M A;  3SWC A;  4Z4P A;  2BQZ A;  4I51 A;  4RZ0 A;  5ARF A;  3MO5 A;  4C1Q A;  3OS5 A;  4E47 A;  4QEP A;  4YPA A;  4YNM A;  1N6A A;  5CCL A;  4JDS A;  4YPU A;  3S7F A;  5KJN A;  2F69 A;  4LDG A;  3M53 A;  3S7J A;  5T5G A;  5KJM A;  5AYF A;  4J8O A;  1MVX A;  5JIN A;  4JLG A;  5TTF A;  5KJK A;  4J7F A;  5F59 A;  2JV0 A;  1N6C A;  3RIB A;  3F9X A;  3M54 A;  5CCM A;  4FMU A;  3QWV A;  3M57 A;  3CBP A;  4NVQ A;  4BUP A;  4H12 A;  3K5K A;  4YND A;  2QPW A;  5EX3 A;  4QEN A;  3OOI A;  3MO2 A;  5F6L A;  5HI7 A;  5KJL A;  3BO5 A;  5LSZ A;  3RJW A;  3RU0 A;  3F9Y A;  1MT6 A;  4IJ8 A;  4NJ5 A;  1XQH A;  3DAL A;  3M5A A;  5TH7 A;  5CPR B;  4AU7 A;  3S7D A;  3SW9 A;  3M56 A;  5ARG A;  3S7B A;  3VUZ A;  5F5E A;  1N3J A;  3FPD A;  1PEG A;  3QWP A;  1MUF A;  1O9S A;  5T0K A;  4YPE A;  4YNP A;  5JIY A;  4MI5 A;  1H3I A;  4J7I A;  3OPE A;  3TG5 A;  3QWW A;  3KMJ A;  5JHN A;  3KMA A;  5LSX A;  3RAY A;  1ZKK A;  4O30 A;  3S8P A;  3M58 A;  3DB5 A;  3CBO A;  3OXF A;  5EX0 A;  4IJD A;  3OXL A;  5F6K C;  5JJ0 A;  3N71 A;  2W5Z A;  3OXG A;  3CBM A;  3F9Z A;  2O8J A;  5TEG A;  3TG4 A;  3PDN A;  4QEO A;  5EG2 A;  2W5Y A;  4J83 A;  2G46 A;  3IHX A;  5HQ8 A;  3HNA A;  4MI0 A;  4O6F A;  1MVH A;  3MO0 A;  3MEK A;  2IGQ A; 
#chains in the Genus database with same CATH topology
 4WUY A;  3RQ4 A;  3EP0 A;  2R3A A;  3F9W A;  3VV0 A;  1ML9 A;  3KMT A;  3M55 A;  2RFI A;  3M59 A;  5T0M A;  3SWC A;  4Z4P A;  2BQZ A;  4I51 A;  4RZ0 A;  5ARF A;  3MO5 A;  4C1Q A;  3OS5 A;  4E47 A;  4QEP A;  4YPA A;  4YNM A;  1N6A A;  5CCL A;  4JDS A;  4YPU A;  3S7F A;  5KJN A;  2F69 A;  4LDG A;  3M53 A;  3S7J A;  5T5G A;  5KJM A;  5AYF A;  4J8O A;  1MVX A;  5JIN A;  4JLG A;  5TTF A;  5KJK A;  4J7F A;  5F59 A;  2JV0 A;  1N6C A;  3RIB A;  3F9X A;  3M54 A;  5CCM A;  4FMU A;  3QWV A;  3M57 A;  3CBP A;  4NVQ A;  4BUP A;  4H12 A;  3K5K A;  4YND A;  2QPW A;  5EX3 A;  4QEN A;  3OOI A;  3MO2 A;  5F6L A;  5HI7 A;  5KJL A;  3BO5 A;  5LSZ A;  3RJW A;  3RU0 A;  3F9Y A;  1MT6 A;  4IJ8 A;  4NJ5 A;  1XQH A;  3DAL A;  3M5A A;  5TH7 A;  5CPR B;  4AU7 A;  3S7D A;  3SW9 A;  3M56 A;  5ARG A;  3S7B A;  3VUZ A;  5F5E A;  1N3J A;  3FPD A;  1PEG A;  3QWP A;  1MUF A;  1O9S A;  5T0K A;  4YPE A;  4YNP A;  5JIY A;  4MI5 A;  1H3I A;  4J7I A;  3OPE A;  3TG5 A;  3QWW A;  3KMJ A;  5JHN A;  3KMA A;  5LSX A;  3RAY A;  1ZKK A;  4O30 A;  3S8P A;  3M58 A;  3DB5 A;  3CBO A;  3OXF A;  5EX0 A;  4IJD A;  3OXL A;  5F6K C;  5JJ0 A;  3N71 A;  2W5Z A;  3OXG A;  3CBM A;  3F9Z A;  2O8J A;  5TEG A;  3TG4 A;  3PDN A;  4QEO A;  5EG2 A;  2W5Y A;  4J83 A;  2G46 A;  3IHX A;  5HQ8 A;  3HNA A;  4MI0 A;  4O6F A;  1MVH A;  3MO0 A;  3MEK A;  2IGQ A; 
#chains in the Genus database with same CATH homology
 4WUY A;  3RQ4 A;  3EP0 A;  2R3A A;  3F9W A;  3VV0 A;  1ML9 A;  3KMT A;  3M55 A;  2RFI A;  3M59 A;  5T0M A;  3SWC A;  4Z4P A;  2BQZ A;  4I51 A;  4RZ0 A;  5ARF A;  3MO5 A;  4C1Q A;  3OS5 A;  4E47 A;  4QEP A;  4YPA A;  4YNM A;  1N6A A;  5CCL A;  4JDS A;  4YPU A;  3S7F A;  5KJN A;  2F69 A;  4LDG A;  3M53 A;  3S7J A;  5T5G A;  5KJM A;  5AYF A;  4J8O A;  1MVX A;  5JIN A;  4JLG A;  5TTF A;  5KJK A;  4J7F A;  5F59 A;  2JV0 A;  1N6C A;  3RIB A;  3F9X A;  3M54 A;  5CCM A;  4FMU A;  3QWV A;  3M57 A;  3CBP A;  4NVQ A;  4BUP A;  4H12 A;  3K5K A;  4YND A;  2QPW A;  5EX3 A;  4QEN A;  3OOI A;  3MO2 A;  5F6L A;  5HI7 A;  5KJL A;  3BO5 A;  5LSZ A;  3RJW A;  3RU0 A;  3F9Y A;  1MT6 A;  4IJ8 A;  4NJ5 A;  1XQH A;  3DAL A;  3M5A A;  5TH7 A;  5CPR B;  4AU7 A;  3S7D A;  3SW9 A;  3M56 A;  5ARG A;  3S7B A;  3VUZ A;  5F5E A;  1N3J A;  3FPD A;  1PEG A;  3QWP A;  1MUF A;  1O9S A;  5T0K A;  4YPE A;  4YNP A;  5JIY A;  4MI5 A;  1H3I A;  4J7I A;  3OPE A;  3TG5 A;  3QWW A;  3KMJ A;  5JHN A;  3KMA A;  5LSX A;  3RAY A;  1ZKK A;  4O30 A;  3S8P A;  3M58 A;  3DB5 A;  3CBO A;  3OXF A;  5EX0 A;  4IJD A;  3OXL A;  5F6K C;  5JJ0 A;  3N71 A;  2W5Z A;  3OXG A;  3CBM A;  3F9Z A;  2O8J A;  5TEG A;  3TG4 A;  3PDN A;  4QEO A;  5EG2 A;  2W5Y A;  4J83 A;  2G46 A;  3IHX A;  5HQ8 A;  3HNA A;  4MI0 A;  4O6F A;  1MVH A;  3MO0 A;  3MEK A;  2IGQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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