3K5KA

Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a potent inhibitor of histone lysine methyltransferase, g9a
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
274
structure length
272
Chain Sequence
b'RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
publication title Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 75
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3k5kA00
3OPEA 4J7IA 3VV0A 3OXGA 3OXFA 3M56A 2W5YA 5TTFA 5EG2A 5EX3A 1XQHA 3K5KA 3KMAA 2BQZA 5F6LA 3EP0A 4JDSA 1MVHA 3DALA 4FMUA 5EX0A 3KMTA 4C1QA 3S8PA 1MVXA 3KMJA 4YPUA 1N6CA 4BUPA 3FPDA 5T5GA 3S7BA 5AYFA 3CBMA 3RAYA 1O9SA 4J83A 5TH7A 3BO5A 3M57A 4NVQA 3S7FA 3OXLA 2R3AA 5F5EA 3N71A 3TG5A 3IHXA 3S7DA 3M59A 2JV0A 4QEPA 3OS5A 2F69A 5ARFA 3SWCA 4O30A 3RIBA 1H3IA 3CBPA 5CPRB 2QPWA 3TG4A 4IJ8A 5JHNA 3RJWA 5CCMA 5CCLA 3M58A 4MI0A 3MO0A 5F6KC 1PEGA 1MUFA 2W5ZA 4AU7A 5F59A 3F9YA 3M54A 5KJNA 4Z4PA 2O8JA 3PDNA 3F9ZA 5JIYA 2G46A 4YNMA 5HQ8A 3DB5A 4NJ5A 5TEGA 4YNPA 5HI7A 3M5AA 3MEKA 3M55A 5LSXA 4YPEA 5LSZA 3M53A 1MT6A 3OOIA 1N6AA 3QWPA 3QWVA 5JJ0A 5JINA 3MO5A 5T0KA 4WUYA 2IGQA 4QEOA 3CBOA 3F9XA 4MI5A 1ZKKA 4H12A 3RU0A 1N3JA 2RFIA 4O6FA 4YNDA 5ARGA 5KJMA 4J7FA 5T0MA 4LDGA 3F9WA 3RQ4A 3QWWA 3HNAA 4I51A 4RZ0A 3VUZA 4J8OA 3MO2A 4YPAA 5KJKA 4QENA 1ML9A 3S7JA 4IJDA 4JLGA 3SW9A 5KJLA 4E47A
chains in the Genus database with same CATH superfamily
3OPEA 4J7IA 3VV0A 3OXGA 3OXFA 3M56A 2W5YA 5TTFA 5EG2A 5EX3A 1XQHA 3K5KA 3KMAA 2BQZA 5F6LA 3EP0A 4JDSA 1MVHA 3DALA 4FMUA 5EX0A 3KMTA 4C1QA 3S8PA 1MVXA 3KMJA 4YPUA 1N6CA 4BUPA 3FPDA 5T5GA 3S7BA 5AYFA 3CBMA 3RAYA 1O9SA 4J83A 5TH7A 3BO5A 3M57A 4NVQA 3S7FA 3OXLA 2R3AA 5F5EA 3N71A 3TG5A 3IHXA 3S7DA 3M59A 2JV0A 4QEPA 3OS5A 2F69A 5ARFA 3SWCA 4O30A 3RIBA 1H3IA 3CBPA 5CPRB 2QPWA 3TG4A 4IJ8A 5JHNA 3RJWA 5CCMA 5CCLA 3M58A 4MI0A 3MO0A 5F6KC 1PEGA 1MUFA 2W5ZA 4AU7A 5F59A 3F9YA 3M54A 5KJNA 4Z4PA 2O8JA 3PDNA 3F9ZA 5JIYA 2G46A 4YNMA 5HQ8A 3DB5A 4NJ5A 5TEGA 4YNPA 5HI7A 3M5AA 3MEKA 3M55A 5LSXA 4YPEA 5LSZA 3M53A 1MT6A 3OOIA 1N6AA 3QWPA 3QWVA 5JJ0A 5JINA 3MO5A 5T0KA 4WUYA 2IGQA 4QEOA 3CBOA 3F9XA 4MI5A 1ZKKA 4H12A 3RU0A 1N3JA 2RFIA 4O6FA 4YNDA 5ARGA 5KJMA 4J7FA 5T0MA 4LDGA 3F9WA 3RQ4A 3QWWA 3HNAA 4I51A 4RZ0A 3VUZA 4J8OA 3MO2A 4YPAA 5KJKA 4QENA 1ML9A 3S7JA 4IJDA 4JLGA 3SW9A 5KJLA 4E47A
chains in the Genus database with same CATH topology
3OPEA 4J7IA 3VV0A 3OXGA 3OXFA 3M56A 2W5YA 5TTFA 5EG2A 5EX3A 1XQHA 3K5KA 3KMAA 2BQZA 5F6LA 3EP0A 4JDSA 1MVHA 3DALA 4FMUA 5EX0A 3KMTA 4C1QA 3S8PA 1MVXA 3KMJA 4YPUA 1N6CA 4BUPA 3FPDA 5T5GA 3S7BA 5AYFA 3CBMA 3RAYA 1O9SA 4J83A 5TH7A 3BO5A 3M57A 4NVQA 3S7FA 3OXLA 2R3AA 5F5EA 3N71A 3TG5A 3IHXA 3S7DA 3M59A 2JV0A 4QEPA 3OS5A 2F69A 5ARFA 3SWCA 4O30A 3RIBA 1H3IA 3CBPA 5CPRB 2QPWA 3TG4A 4IJ8A 5JHNA 3RJWA 5CCMA 5CCLA 3M58A 4MI0A 3MO0A 5F6KC 1PEGA 1MUFA 2W5ZA 4AU7A 5F59A 3F9YA 3M54A 5KJNA 4Z4PA 2O8JA 3PDNA 3F9ZA 5JIYA 2G46A 4YNMA 5HQ8A 3DB5A 4NJ5A 5TEGA 4YNPA 5HI7A 3M5AA 3MEKA 3M55A 5LSXA 4YPEA 5LSZA 3M53A 1MT6A 3OOIA 1N6AA 3QWPA 3QWVA 5JJ0A 5JINA 3MO5A 5T0KA 4WUYA 2IGQA 4QEOA 3CBOA 3F9XA 4MI5A 1ZKKA 4H12A 3RU0A 1N3JA 2RFIA 4O6FA 4YNDA 5ARGA 5KJMA 4J7FA 5T0MA 4LDGA 3F9WA 3RQ4A 3QWWA 3HNAA 4I51A 4RZ0A 3VUZA 4J8OA 3MO2A 4YPAA 5KJKA 4QENA 1ML9A 3S7JA 4IJDA 4JLGA 3SW9A 5KJLA 4E47A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OPE A;  4J7I A;  3VV0 A;  3OXG A;  3OXF A;  3M56 A;  2W5Y A;  5TTF A;  5EG2 A;  5EX3 A;  1XQH A;  3K5K A;  3KMA A;  2BQZ A;  5F6L A;  3EP0 A;  4JDS A;  1MVH A;  3DAL A;  4FMU A;  5EX0 A;  3KMT A;  4C1Q A;  3S8P A;  1MVX A;  3KMJ A;  4YPU A;  1N6C A;  4BUP A;  3FPD A;  5T5G A;  3S7B A;  5AYF A;  3CBM A;  3RAY A;  1O9S A;  4J83 A;  5TH7 A;  3BO5 A;  3M57 A;  4NVQ A;  3S7F A;  3OXL A;  2R3A A;  5F5E A;  3N71 A;  3TG5 A;  3IHX A;  3S7D A;  3M59 A;  2JV0 A;  4QEP A;  3OS5 A;  2F69 A;  5ARF A;  3SWC A;  4O30 A;  3RIB A;  1H3I A;  3CBP A;  5CPR B;  2QPW A;  3TG4 A;  4IJ8 A;  5JHN A;  3RJW A;  5CCM A;  5CCL A;  3M58 A;  4MI0 A;  3MO0 A;  5F6K C;  1PEG A;  1MUF A;  2W5Z A;  4AU7 A;  5F59 A;  3F9Y A;  3M54 A;  5KJN A;  4Z4P A;  2O8J A;  3PDN A;  3F9Z A;  5JIY A;  2G46 A;  4YNM A;  5HQ8 A;  3DB5 A;  4NJ5 A;  5TEG A;  4YNP A;  5HI7 A;  3M5A A;  3MEK A;  3M55 A;  5LSX A;  4YPE A;  5LSZ A;  3M53 A;  1MT6 A;  3OOI A;  1N6A A;  3QWP A;  3QWV A;  5JJ0 A;  5JIN A;  3MO5 A;  5T0K A;  4WUY A;  2IGQ A;  4QEO A;  3CBO A;  3F9X A;  4MI5 A;  1ZKK A;  4H12 A;  3RU0 A;  1N3J A;  2RFI A;  4O6F A;  4YND A;  5ARG A;  5KJM A;  4J7F A;  5T0M A;  4LDG A;  3F9W A;  3RQ4 A;  3QWW A;  3HNA A;  4I51 A;  4RZ0 A;  3VUZ A;  4J8O A;  3MO2 A;  4YPA A;  5KJK A;  4QEN A;  1ML9 A;  3S7J A;  4IJD A;  4JLG A;  3SW9 A;  5KJL A;  4E47 A; 
#chains in the Genus database with same CATH topology
 3OPE A;  4J7I A;  3VV0 A;  3OXG A;  3OXF A;  3M56 A;  2W5Y A;  5TTF A;  5EG2 A;  5EX3 A;  1XQH A;  3K5K A;  3KMA A;  2BQZ A;  5F6L A;  3EP0 A;  4JDS A;  1MVH A;  3DAL A;  4FMU A;  5EX0 A;  3KMT A;  4C1Q A;  3S8P A;  1MVX A;  3KMJ A;  4YPU A;  1N6C A;  4BUP A;  3FPD A;  5T5G A;  3S7B A;  5AYF A;  3CBM A;  3RAY A;  1O9S A;  4J83 A;  5TH7 A;  3BO5 A;  3M57 A;  4NVQ A;  3S7F A;  3OXL A;  2R3A A;  5F5E A;  3N71 A;  3TG5 A;  3IHX A;  3S7D A;  3M59 A;  2JV0 A;  4QEP A;  3OS5 A;  2F69 A;  5ARF A;  3SWC A;  4O30 A;  3RIB A;  1H3I A;  3CBP A;  5CPR B;  2QPW A;  3TG4 A;  4IJ8 A;  5JHN A;  3RJW A;  5CCM A;  5CCL A;  3M58 A;  4MI0 A;  3MO0 A;  5F6K C;  1PEG A;  1MUF A;  2W5Z A;  4AU7 A;  5F59 A;  3F9Y A;  3M54 A;  5KJN A;  4Z4P A;  2O8J A;  3PDN A;  3F9Z A;  5JIY A;  2G46 A;  4YNM A;  5HQ8 A;  3DB5 A;  4NJ5 A;  5TEG A;  4YNP A;  5HI7 A;  3M5A A;  3MEK A;  3M55 A;  5LSX A;  4YPE A;  5LSZ A;  3M53 A;  1MT6 A;  3OOI A;  1N6A A;  3QWP A;  3QWV A;  5JJ0 A;  5JIN A;  3MO5 A;  5T0K A;  4WUY A;  2IGQ A;  4QEO A;  3CBO A;  3F9X A;  4MI5 A;  1ZKK A;  4H12 A;  3RU0 A;  1N3J A;  2RFI A;  4O6F A;  4YND A;  5ARG A;  5KJM A;  4J7F A;  5T0M A;  4LDG A;  3F9W A;  3RQ4 A;  3QWW A;  3HNA A;  4I51 A;  4RZ0 A;  3VUZ A;  4J8O A;  3MO2 A;  4YPA A;  5KJK A;  4QEN A;  1ML9 A;  3S7J A;  4IJD A;  4JLG A;  3SW9 A;  5KJL A;  4E47 A; 
#chains in the Genus database with same CATH homology
 3OPE A;  4J7I A;  3VV0 A;  3OXG A;  3OXF A;  3M56 A;  2W5Y A;  5TTF A;  5EG2 A;  5EX3 A;  1XQH A;  3K5K A;  3KMA A;  2BQZ A;  5F6L A;  3EP0 A;  4JDS A;  1MVH A;  3DAL A;  4FMU A;  5EX0 A;  3KMT A;  4C1Q A;  3S8P A;  1MVX A;  3KMJ A;  4YPU A;  1N6C A;  4BUP A;  3FPD A;  5T5G A;  3S7B A;  5AYF A;  3CBM A;  3RAY A;  1O9S A;  4J83 A;  5TH7 A;  3BO5 A;  3M57 A;  4NVQ A;  3S7F A;  3OXL A;  2R3A A;  5F5E A;  3N71 A;  3TG5 A;  3IHX A;  3S7D A;  3M59 A;  2JV0 A;  4QEP A;  3OS5 A;  2F69 A;  5ARF A;  3SWC A;  4O30 A;  3RIB A;  1H3I A;  3CBP A;  5CPR B;  2QPW A;  3TG4 A;  4IJ8 A;  5JHN A;  3RJW A;  5CCM A;  5CCL A;  3M58 A;  4MI0 A;  3MO0 A;  5F6K C;  1PEG A;  1MUF A;  2W5Z A;  4AU7 A;  5F59 A;  3F9Y A;  3M54 A;  5KJN A;  4Z4P A;  2O8J A;  3PDN A;  3F9Z A;  5JIY A;  2G46 A;  4YNM A;  5HQ8 A;  3DB5 A;  4NJ5 A;  5TEG A;  4YNP A;  5HI7 A;  3M5A A;  3MEK A;  3M55 A;  5LSX A;  4YPE A;  5LSZ A;  3M53 A;  1MT6 A;  3OOI A;  1N6A A;  3QWP A;  3QWV A;  5JJ0 A;  5JIN A;  3MO5 A;  5T0K A;  4WUY A;  2IGQ A;  4QEO A;  3CBO A;  3F9X A;  4MI5 A;  1ZKK A;  4H12 A;  3RU0 A;  1N3J A;  2RFI A;  4O6F A;  4YND A;  5ARG A;  5KJM A;  4J7F A;  5T0M A;  4LDG A;  3F9W A;  3RQ4 A;  3QWW A;  3HNA A;  4I51 A;  4RZ0 A;  3VUZ A;  4J8O A;  3MO2 A;  4YPA A;  5KJK A;  4QEN A;  1ML9 A;  3S7J A;  4IJD A;  4JLG A;  3SW9 A;  5KJL A;  4E47 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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