4MI0A

Human enhancer of zeste (drosophila) homolog 2(ezh2)
Total Genus 46
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
210
structure length
208
Chain Sequence
YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EZH2
publication title Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 46
structure length 208
sequence length 210
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF18264 preSET_CXC CXC domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4mi0A00
4J7FA 5JJ0A 4JLGA 2W5YA 3S7JA 2F69A 3QWPA 2RFIA 1N6AA 3KMAA 5CPRB 5F59A 3K5KA 4Z4PA 5HQ8A 4J83A 3VV0A 3RJWA 3OXLA 4MI5A 5CCMA 4QEOA 1N6CA 1ZKKA 4FMUA 4RZ0A 5EG2A 3S8PA 5KJKA 5F5EA 4YNMA 3TG4A 5KJLA 3RAYA 4QENA 3PDNA 1N3JA 3M55A 3TG5A 4J7IA 1MT6A 5JHNA 5JINA 5T0MA 4E47A 5HI7A 3F9YA 5CCLA 3CBMA 4O6FA 5F6KC 3OPEA 3DALA 4AU7A 3MEKA 3KMTA 2R3AA 5F6LA 3M57A 3OS5A 3MO0A 3CBPA 4IJDA 5EX3A 5AYFA 3QWWA 3F9ZA 3M58A 3N71A 1ML9A 4YPEA 3KMJA 3SW9A 5LSXA 5TEGA 1PEGA 4H12A 4BUPA 1MVHA 4LDGA 5EX0A 3BO5A 4C1QA 3HNAA 3M5AA 5ARFA 5JIYA 2O8JA 4NJ5A 1MVXA 2G46A 3S7DA 3F9WA 5LSZA 2JV0A 4JDSA 3CBOA 4YPUA 5T0KA 3OOIA 5KJNA 1XQHA 4I51A 3SWCA 3VUZA 2QPWA 3F9XA 4IJ8A 4QEPA 3M56A 2W5ZA 3MO2A 3DB5A 4WUYA 3RU0A 5KJMA 1O9SA 5TTFA 3IHXA 1MUFA 2IGQA 3M54A 3OXFA 1H3IA 4YNPA 3EP0A 3M53A 3RQ4A 3OXGA 3S7BA 3M59A 3FPDA 3QWVA 4NVQA 4YNDA 3S7FA 3RIBA 4MI0A 2BQZA 4YPAA 5ARGA 5T5GA 4O30A 4J8OA 3MO5A 5TH7A
chains in the Genus database with same CATH superfamily
4J7FA 5JJ0A 4JLGA 2W5YA 3S7JA 2F69A 3QWPA 2RFIA 1N6AA 3KMAA 5CPRB 5F59A 3K5KA 4Z4PA 5HQ8A 4J83A 3VV0A 3RJWA 3OXLA 4MI5A 5CCMA 4QEOA 1N6CA 1ZKKA 4FMUA 4RZ0A 5EG2A 3S8PA 5KJKA 5F5EA 4YNMA 3TG4A 5KJLA 3RAYA 4QENA 3PDNA 1N3JA 3M55A 3TG5A 4J7IA 1MT6A 5JHNA 5JINA 5T0MA 4E47A 5HI7A 3F9YA 5CCLA 3CBMA 4O6FA 5F6KC 3OPEA 3DALA 4AU7A 3MEKA 3KMTA 2R3AA 5F6LA 3M57A 3OS5A 3MO0A 3CBPA 4IJDA 5EX3A 5AYFA 3QWWA 3F9ZA 3M58A 3N71A 1ML9A 4YPEA 3KMJA 3SW9A 5LSXA 5TEGA 1PEGA 4H12A 4BUPA 1MVHA 4LDGA 5EX0A 3BO5A 4C1QA 3HNAA 3M5AA 5ARFA 5JIYA 2O8JA 4NJ5A 1MVXA 2G46A 3S7DA 3F9WA 5LSZA 2JV0A 4JDSA 3CBOA 4YPUA 5T0KA 3OOIA 5KJNA 1XQHA 4I51A 3SWCA 3VUZA 2QPWA 3F9XA 4IJ8A 4QEPA 3M56A 2W5ZA 3MO2A 3DB5A 4WUYA 3RU0A 5KJMA 1O9SA 5TTFA 3IHXA 1MUFA 2IGQA 3M54A 3OXFA 1H3IA 4YNPA 3EP0A 3M53A 3RQ4A 3OXGA 3S7BA 3M59A 3FPDA 3QWVA 4NVQA 4YNDA 3S7FA 3RIBA 4MI0A 2BQZA 4YPAA 5ARGA 5T5GA 4O30A 4J8OA 3MO5A 5TH7A
chains in the Genus database with same CATH topology
4J7FA 5JJ0A 4JLGA 2W5YA 3S7JA 2F69A 3QWPA 2RFIA 1N6AA 3KMAA 5CPRB 5F59A 3K5KA 4Z4PA 5HQ8A 4J83A 3VV0A 3RJWA 3OXLA 4MI5A 5CCMA 4QEOA 1N6CA 1ZKKA 4FMUA 4RZ0A 5EG2A 3S8PA 5KJKA 5F5EA 4YNMA 3TG4A 5KJLA 3RAYA 4QENA 3PDNA 1N3JA 3M55A 3TG5A 4J7IA 1MT6A 5JHNA 5JINA 5T0MA 4E47A 5HI7A 3F9YA 5CCLA 3CBMA 4O6FA 5F6KC 3OPEA 3DALA 4AU7A 3MEKA 3KMTA 2R3AA 5F6LA 3M57A 3OS5A 3MO0A 3CBPA 4IJDA 5EX3A 5AYFA 3QWWA 3F9ZA 3M58A 3N71A 1ML9A 4YPEA 3KMJA 3SW9A 5LSXA 5TEGA 1PEGA 4H12A 4BUPA 1MVHA 4LDGA 5EX0A 3BO5A 4C1QA 3HNAA 3M5AA 5ARFA 5JIYA 2O8JA 4NJ5A 1MVXA 2G46A 3S7DA 3F9WA 5LSZA 2JV0A 4JDSA 3CBOA 4YPUA 5T0KA 3OOIA 5KJNA 1XQHA 4I51A 3SWCA 3VUZA 2QPWA 3F9XA 4IJ8A 4QEPA 3M56A 2W5ZA 3MO2A 3DB5A 4WUYA 3RU0A 5KJMA 1O9SA 5TTFA 3IHXA 1MUFA 2IGQA 3M54A 3OXFA 1H3IA 4YNPA 3EP0A 3M53A 3RQ4A 3OXGA 3S7BA 3M59A 3FPDA 3QWVA 4NVQA 4YNDA 3S7FA 3RIBA 4MI0A 2BQZA 4YPAA 5ARGA 5T5GA 4O30A 4J8OA 3MO5A 5TH7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7F A;  5JJ0 A;  4JLG A;  2W5Y A;  3S7J A;  2F69 A;  3QWP A;  2RFI A;  1N6A A;  3KMA A;  5CPR B;  5F59 A;  3K5K A;  4Z4P A;  5HQ8 A;  4J83 A;  3VV0 A;  3RJW A;  3OXL A;  4MI5 A;  5CCM A;  4QEO A;  1N6C A;  1ZKK A;  4FMU A;  4RZ0 A;  5EG2 A;  3S8P A;  5KJK A;  5F5E A;  4YNM A;  3TG4 A;  5KJL A;  3RAY A;  4QEN A;  3PDN A;  1N3J A;  3M55 A;  3TG5 A;  4J7I A;  1MT6 A;  5JHN A;  5JIN A;  5T0M A;  4E47 A;  5HI7 A;  3F9Y A;  5CCL A;  3CBM A;  4O6F A;  5F6K C;  3OPE A;  3DAL A;  4AU7 A;  3MEK A;  3KMT A;  2R3A A;  5F6L A;  3M57 A;  3OS5 A;  3MO0 A;  3CBP A;  4IJD A;  5EX3 A;  5AYF A;  3QWW A;  3F9Z A;  3M58 A;  3N71 A;  1ML9 A;  4YPE A;  3KMJ A;  3SW9 A;  5LSX A;  5TEG A;  1PEG A;  4H12 A;  4BUP A;  1MVH A;  4LDG A;  5EX0 A;  3BO5 A;  4C1Q A;  3HNA A;  3M5A A;  5ARF A;  5JIY A;  2O8J A;  4NJ5 A;  1MVX A;  2G46 A;  3S7D A;  3F9W A;  5LSZ A;  2JV0 A;  4JDS A;  3CBO A;  4YPU A;  5T0K A;  3OOI A;  5KJN A;  1XQH A;  4I51 A;  3SWC A;  3VUZ A;  2QPW A;  3F9X A;  4IJ8 A;  4QEP A;  3M56 A;  2W5Z A;  3MO2 A;  3DB5 A;  4WUY A;  3RU0 A;  5KJM A;  1O9S A;  5TTF A;  3IHX A;  1MUF A;  2IGQ A;  3M54 A;  3OXF A;  1H3I A;  4YNP A;  3EP0 A;  3M53 A;  3RQ4 A;  3OXG A;  3S7B A;  3M59 A;  3FPD A;  3QWV A;  4NVQ A;  4YND A;  3S7F A;  3RIB A;  4MI0 A;  2BQZ A;  4YPA A;  5ARG A;  5T5G A;  4O30 A;  4J8O A;  3MO5 A;  5TH7 A; 
#chains in the Genus database with same CATH topology
 4J7F A;  5JJ0 A;  4JLG A;  2W5Y A;  3S7J A;  2F69 A;  3QWP A;  2RFI A;  1N6A A;  3KMA A;  5CPR B;  5F59 A;  3K5K A;  4Z4P A;  5HQ8 A;  4J83 A;  3VV0 A;  3RJW A;  3OXL A;  4MI5 A;  5CCM A;  4QEO A;  1N6C A;  1ZKK A;  4FMU A;  4RZ0 A;  5EG2 A;  3S8P A;  5KJK A;  5F5E A;  4YNM A;  3TG4 A;  5KJL A;  3RAY A;  4QEN A;  3PDN A;  1N3J A;  3M55 A;  3TG5 A;  4J7I A;  1MT6 A;  5JHN A;  5JIN A;  5T0M A;  4E47 A;  5HI7 A;  3F9Y A;  5CCL A;  3CBM A;  4O6F A;  5F6K C;  3OPE A;  3DAL A;  4AU7 A;  3MEK A;  3KMT A;  2R3A A;  5F6L A;  3M57 A;  3OS5 A;  3MO0 A;  3CBP A;  4IJD A;  5EX3 A;  5AYF A;  3QWW A;  3F9Z A;  3M58 A;  3N71 A;  1ML9 A;  4YPE A;  3KMJ A;  3SW9 A;  5LSX A;  5TEG A;  1PEG A;  4H12 A;  4BUP A;  1MVH A;  4LDG A;  5EX0 A;  3BO5 A;  4C1Q A;  3HNA A;  3M5A A;  5ARF A;  5JIY A;  2O8J A;  4NJ5 A;  1MVX A;  2G46 A;  3S7D A;  3F9W A;  5LSZ A;  2JV0 A;  4JDS A;  3CBO A;  4YPU A;  5T0K A;  3OOI A;  5KJN A;  1XQH A;  4I51 A;  3SWC A;  3VUZ A;  2QPW A;  3F9X A;  4IJ8 A;  4QEP A;  3M56 A;  2W5Z A;  3MO2 A;  3DB5 A;  4WUY A;  3RU0 A;  5KJM A;  1O9S A;  5TTF A;  3IHX A;  1MUF A;  2IGQ A;  3M54 A;  3OXF A;  1H3I A;  4YNP A;  3EP0 A;  3M53 A;  3RQ4 A;  3OXG A;  3S7B A;  3M59 A;  3FPD A;  3QWV A;  4NVQ A;  4YND A;  3S7F A;  3RIB A;  4MI0 A;  2BQZ A;  4YPA A;  5ARG A;  5T5G A;  4O30 A;  4J8O A;  3MO5 A;  5TH7 A; 
#chains in the Genus database with same CATH homology
 4J7F A;  5JJ0 A;  4JLG A;  2W5Y A;  3S7J A;  2F69 A;  3QWP A;  2RFI A;  1N6A A;  3KMA A;  5CPR B;  5F59 A;  3K5K A;  4Z4P A;  5HQ8 A;  4J83 A;  3VV0 A;  3RJW A;  3OXL A;  4MI5 A;  5CCM A;  4QEO A;  1N6C A;  1ZKK A;  4FMU A;  4RZ0 A;  5EG2 A;  3S8P A;  5KJK A;  5F5E A;  4YNM A;  3TG4 A;  5KJL A;  3RAY A;  4QEN A;  3PDN A;  1N3J A;  3M55 A;  3TG5 A;  4J7I A;  1MT6 A;  5JHN A;  5JIN A;  5T0M A;  4E47 A;  5HI7 A;  3F9Y A;  5CCL A;  3CBM A;  4O6F A;  5F6K C;  3OPE A;  3DAL A;  4AU7 A;  3MEK A;  3KMT A;  2R3A A;  5F6L A;  3M57 A;  3OS5 A;  3MO0 A;  3CBP A;  4IJD A;  5EX3 A;  5AYF A;  3QWW A;  3F9Z A;  3M58 A;  3N71 A;  1ML9 A;  4YPE A;  3KMJ A;  3SW9 A;  5LSX A;  5TEG A;  1PEG A;  4H12 A;  4BUP A;  1MVH A;  4LDG A;  5EX0 A;  3BO5 A;  4C1Q A;  3HNA A;  3M5A A;  5ARF A;  5JIY A;  2O8J A;  4NJ5 A;  1MVX A;  2G46 A;  3S7D A;  3F9W A;  5LSZ A;  2JV0 A;  4JDS A;  3CBO A;  4YPU A;  5T0K A;  3OOI A;  5KJN A;  1XQH A;  4I51 A;  3SWC A;  3VUZ A;  2QPW A;  3F9X A;  4IJ8 A;  4QEP A;  3M56 A;  2W5Z A;  3MO2 A;  3DB5 A;  4WUY A;  3RU0 A;  5KJM A;  1O9S A;  5TTF A;  3IHX A;  1MUF A;  2IGQ A;  3M54 A;  3OXF A;  1H3I A;  4YNP A;  3EP0 A;  3M53 A;  3RQ4 A;  3OXG A;  3S7B A;  3M59 A;  3FPD A;  3QWV A;  4NVQ A;  4YND A;  3S7F A;  3RIB A;  4MI0 A;  2BQZ A;  4YPA A;  5ARG A;  5T5G A;  4O30 A;  4J8O A;  3MO5 A;  5TH7 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...