4MI0A

Human enhancer of zeste (drosophila) homolog 2(ezh2)
Total Genus 46
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
210
structure length
208
Chain Sequence
YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Homo sapiens
publication title Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
pubmed doi rcsb
molecule keywords Histone-lysine N-methyltransferase EZH2
total genus 46
structure length 208
sequence length 210
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF18264 preSET_CXC CXC domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4mi0A00
4RZ0A 2F69A 3TG4A 5F5EA 2W5ZA 3OXFA 3KMAA 3OXLA 4YNMA 3F9WA 3CBPA 4AU7A 3S7BA 3S7JA 5KJLA 3M53A 4BUPA 2O8JA 3IHXA 5HI7A 1MUFA 3DALA 4O6FA 3M5AA 3DB5A 3FPDA 1PEGA 5F6KC 5CCLA 3S7DA 4I51A 4J7IA 2IGQA 3QWVA 4LDGA 3M55A 3K5KA 5EX0A 5AYFA 1H3IA 1MVXA 3M57A 3M59A 4YPEA 5TH7A 5KJMA 4QENA 1ML9A 1ZKKA 5JINA 3KMJA 3OXGA 4FMUA 5T0MA 3VUZA 3PDNA 4NVQA 3M54A 3OPEA 5LSXA 3TG5A 4J7FA 5JIYA 5ARGA 4J83A 3EP0A 2BQZA 3RIBA 4E47A 3QWWA 4Z4PA 4QEOA 5TTFA 1N6AA 3BO5A 2JV0A 4J8OA 4MI5A 2W5YA 3KMTA 2G46A 3S7FA 5JJ0A 3RAYA 1N6CA 3S8PA 1MVHA 3QWPA 4H12A 3RU0A 5F59A 3N71A 4YPUA 4YNPA 4C1QA 5CPRB 3MEKA 3RQ4A 5KJKA 1MT6A 4NJ5A 5ARFA 4IJDA 5T0KA 5T5GA 3SWCA 4O30A 3OOIA 3M56A 2R3AA 5JHNA 3SW9A 4JLGA 5CCMA 4QEPA 3MO0A 5EG2A 1N3JA 3OS5A 3CBMA 3MO5A 4JDSA 3M58A 3MO2A 4IJ8A 5KJNA 4MI0A 5HQ8A 3VV0A 4YPAA 4YNDA 3CBOA 4WUYA 2QPWA 3F9YA 5F6LA 1O9SA 1XQHA 2RFIA 5LSZA 5TEGA 3F9XA 3F9ZA 5EX3A 3RJWA 3HNAA
chains in the Genus database with same CATH superfamily
4RZ0A 2F69A 3TG4A 5F5EA 2W5ZA 3OXFA 3KMAA 3OXLA 4YNMA 3F9WA 3CBPA 4AU7A 3S7BA 3S7JA 5KJLA 3M53A 4BUPA 2O8JA 3IHXA 5HI7A 1MUFA 3DALA 4O6FA 3M5AA 3DB5A 3FPDA 1PEGA 5F6KC 5CCLA 3S7DA 4I51A 4J7IA 2IGQA 3QWVA 4LDGA 3M55A 3K5KA 5EX0A 5AYFA 1H3IA 1MVXA 3M57A 3M59A 4YPEA 5TH7A 5KJMA 4QENA 1ML9A 1ZKKA 5JINA 3KMJA 3OXGA 4FMUA 5T0MA 3VUZA 3PDNA 4NVQA 3M54A 3OPEA 5LSXA 3TG5A 4J7FA 5JIYA 5ARGA 4J83A 3EP0A 2BQZA 3RIBA 4E47A 3QWWA 4Z4PA 4QEOA 5TTFA 1N6AA 3BO5A 2JV0A 4J8OA 4MI5A 2W5YA 3KMTA 2G46A 3S7FA 5JJ0A 3RAYA 1N6CA 3S8PA 1MVHA 3QWPA 4H12A 3RU0A 5F59A 3N71A 4YPUA 4YNPA 4C1QA 5CPRB 3MEKA 3RQ4A 5KJKA 1MT6A 4NJ5A 5ARFA 4IJDA 5T0KA 5T5GA 3SWCA 4O30A 3OOIA 3M56A 2R3AA 5JHNA 3SW9A 4JLGA 5CCMA 4QEPA 3MO0A 5EG2A 1N3JA 3OS5A 3CBMA 3MO5A 4JDSA 3M58A 3MO2A 4IJ8A 5KJNA 4MI0A 5HQ8A 3VV0A 4YPAA 4YNDA 3CBOA 4WUYA 2QPWA 3F9YA 5F6LA 1O9SA 1XQHA 2RFIA 5LSZA 5TEGA 3F9XA 3F9ZA 5EX3A 3RJWA 3HNAA
chains in the Genus database with same CATH topology
4RZ0A 2F69A 3TG4A 5F5EA 2W5ZA 3OXFA 3KMAA 3OXLA 4YNMA 3F9WA 3CBPA 4AU7A 3S7BA 3S7JA 5KJLA 3M53A 4BUPA 2O8JA 3IHXA 5HI7A 1MUFA 3DALA 4O6FA 3M5AA 3DB5A 3FPDA 1PEGA 5F6KC 5CCLA 3S7DA 4I51A 4J7IA 2IGQA 3QWVA 4LDGA 3M55A 3K5KA 5EX0A 5AYFA 1H3IA 1MVXA 3M57A 3M59A 4YPEA 5TH7A 5KJMA 4QENA 1ML9A 1ZKKA 5JINA 3KMJA 3OXGA 4FMUA 5T0MA 3VUZA 3PDNA 4NVQA 3M54A 3OPEA 5LSXA 3TG5A 4J7FA 5JIYA 5ARGA 4J83A 3EP0A 2BQZA 3RIBA 4E47A 3QWWA 4Z4PA 4QEOA 5TTFA 1N6AA 3BO5A 2JV0A 4J8OA 4MI5A 2W5YA 3KMTA 2G46A 3S7FA 5JJ0A 3RAYA 1N6CA 3S8PA 1MVHA 3QWPA 4H12A 3RU0A 5F59A 3N71A 4YPUA 4YNPA 4C1QA 5CPRB 3MEKA 3RQ4A 5KJKA 1MT6A 4NJ5A 5ARFA 4IJDA 5T0KA 5T5GA 3SWCA 4O30A 3OOIA 3M56A 2R3AA 5JHNA 3SW9A 4JLGA 5CCMA 4QEPA 3MO0A 5EG2A 1N3JA 3OS5A 3CBMA 3MO5A 4JDSA 3M58A 3MO2A 4IJ8A 5KJNA 4MI0A 5HQ8A 3VV0A 4YPAA 4YNDA 3CBOA 4WUYA 2QPWA 3F9YA 5F6LA 1O9SA 1XQHA 2RFIA 5LSZA 5TEGA 3F9XA 3F9ZA 5EX3A 3RJWA 3HNAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RZ0 A;  2F69 A;  3TG4 A;  5F5E A;  2W5Z A;  3OXF A;  3KMA A;  3OXL A;  4YNM A;  3F9W A;  3CBP A;  4AU7 A;  3S7B A;  3S7J A;  5KJL A;  3M53 A;  4BUP A;  2O8J A;  3IHX A;  5HI7 A;  1MUF A;  3DAL A;  4O6F A;  3M5A A;  3DB5 A;  3FPD A;  1PEG A;  5F6K C;  5CCL A;  3S7D A;  4I51 A;  4J7I A;  2IGQ A;  3QWV A;  4LDG A;  3M55 A;  3K5K A;  5EX0 A;  5AYF A;  1H3I A;  1MVX A;  3M57 A;  3M59 A;  4YPE A;  5TH7 A;  5KJM A;  4QEN A;  1ML9 A;  1ZKK A;  5JIN A;  3KMJ A;  3OXG A;  4FMU A;  5T0M A;  3VUZ A;  3PDN A;  4NVQ A;  3M54 A;  3OPE A;  5LSX A;  3TG5 A;  4J7F A;  5JIY A;  5ARG A;  4J83 A;  3EP0 A;  2BQZ A;  3RIB A;  4E47 A;  3QWW A;  4Z4P A;  4QEO A;  5TTF A;  1N6A A;  3BO5 A;  2JV0 A;  4J8O A;  4MI5 A;  2W5Y A;  3KMT A;  2G46 A;  3S7F A;  5JJ0 A;  3RAY A;  1N6C A;  3S8P A;  1MVH A;  3QWP A;  4H12 A;  3RU0 A;  5F59 A;  3N71 A;  4YPU A;  4YNP A;  4C1Q A;  5CPR B;  3MEK A;  3RQ4 A;  5KJK A;  1MT6 A;  4NJ5 A;  5ARF A;  4IJD A;  5T0K A;  5T5G A;  3SWC A;  4O30 A;  3OOI A;  3M56 A;  2R3A A;  5JHN A;  3SW9 A;  4JLG A;  5CCM A;  4QEP A;  3MO0 A;  5EG2 A;  1N3J A;  3OS5 A;  3CBM A;  3MO5 A;  4JDS A;  3M58 A;  3MO2 A;  4IJ8 A;  5KJN A;  4MI0 A;  5HQ8 A;  3VV0 A;  4YPA A;  4YND A;  3CBO A;  4WUY A;  2QPW A;  3F9Y A;  5F6L A;  1O9S A;  1XQH A;  2RFI A;  5LSZ A;  5TEG A;  3F9X A;  3F9Z A;  5EX3 A;  3RJW A;  3HNA A; 
#chains in the Genus database with same CATH topology
 4RZ0 A;  2F69 A;  3TG4 A;  5F5E A;  2W5Z A;  3OXF A;  3KMA A;  3OXL A;  4YNM A;  3F9W A;  3CBP A;  4AU7 A;  3S7B A;  3S7J A;  5KJL A;  3M53 A;  4BUP A;  2O8J A;  3IHX A;  5HI7 A;  1MUF A;  3DAL A;  4O6F A;  3M5A A;  3DB5 A;  3FPD A;  1PEG A;  5F6K C;  5CCL A;  3S7D A;  4I51 A;  4J7I A;  2IGQ A;  3QWV A;  4LDG A;  3M55 A;  3K5K A;  5EX0 A;  5AYF A;  1H3I A;  1MVX A;  3M57 A;  3M59 A;  4YPE A;  5TH7 A;  5KJM A;  4QEN A;  1ML9 A;  1ZKK A;  5JIN A;  3KMJ A;  3OXG A;  4FMU A;  5T0M A;  3VUZ A;  3PDN A;  4NVQ A;  3M54 A;  3OPE A;  5LSX A;  3TG5 A;  4J7F A;  5JIY A;  5ARG A;  4J83 A;  3EP0 A;  2BQZ A;  3RIB A;  4E47 A;  3QWW A;  4Z4P A;  4QEO A;  5TTF A;  1N6A A;  3BO5 A;  2JV0 A;  4J8O A;  4MI5 A;  2W5Y A;  3KMT A;  2G46 A;  3S7F A;  5JJ0 A;  3RAY A;  1N6C A;  3S8P A;  1MVH A;  3QWP A;  4H12 A;  3RU0 A;  5F59 A;  3N71 A;  4YPU A;  4YNP A;  4C1Q A;  5CPR B;  3MEK A;  3RQ4 A;  5KJK A;  1MT6 A;  4NJ5 A;  5ARF A;  4IJD A;  5T0K A;  5T5G A;  3SWC A;  4O30 A;  3OOI A;  3M56 A;  2R3A A;  5JHN A;  3SW9 A;  4JLG A;  5CCM A;  4QEP A;  3MO0 A;  5EG2 A;  1N3J A;  3OS5 A;  3CBM A;  3MO5 A;  4JDS A;  3M58 A;  3MO2 A;  4IJ8 A;  5KJN A;  4MI0 A;  5HQ8 A;  3VV0 A;  4YPA A;  4YND A;  3CBO A;  4WUY A;  2QPW A;  3F9Y A;  5F6L A;  1O9S A;  1XQH A;  2RFI A;  5LSZ A;  5TEG A;  3F9X A;  3F9Z A;  5EX3 A;  3RJW A;  3HNA A; 
#chains in the Genus database with same CATH homology
 4RZ0 A;  2F69 A;  3TG4 A;  5F5E A;  2W5Z A;  3OXF A;  3KMA A;  3OXL A;  4YNM A;  3F9W A;  3CBP A;  4AU7 A;  3S7B A;  3S7J A;  5KJL A;  3M53 A;  4BUP A;  2O8J A;  3IHX A;  5HI7 A;  1MUF A;  3DAL A;  4O6F A;  3M5A A;  3DB5 A;  3FPD A;  1PEG A;  5F6K C;  5CCL A;  3S7D A;  4I51 A;  4J7I A;  2IGQ A;  3QWV A;  4LDG A;  3M55 A;  3K5K A;  5EX0 A;  5AYF A;  1H3I A;  1MVX A;  3M57 A;  3M59 A;  4YPE A;  5TH7 A;  5KJM A;  4QEN A;  1ML9 A;  1ZKK A;  5JIN A;  3KMJ A;  3OXG A;  4FMU A;  5T0M A;  3VUZ A;  3PDN A;  4NVQ A;  3M54 A;  3OPE A;  5LSX A;  3TG5 A;  4J7F A;  5JIY A;  5ARG A;  4J83 A;  3EP0 A;  2BQZ A;  3RIB A;  4E47 A;  3QWW A;  4Z4P A;  4QEO A;  5TTF A;  1N6A A;  3BO5 A;  2JV0 A;  4J8O A;  4MI5 A;  2W5Y A;  3KMT A;  2G46 A;  3S7F A;  5JJ0 A;  3RAY A;  1N6C A;  3S8P A;  1MVH A;  3QWP A;  4H12 A;  3RU0 A;  5F59 A;  3N71 A;  4YPU A;  4YNP A;  4C1Q A;  5CPR B;  3MEK A;  3RQ4 A;  5KJK A;  1MT6 A;  4NJ5 A;  5ARF A;  4IJD A;  5T0K A;  5T5G A;  3SWC A;  4O30 A;  3OOI A;  3M56 A;  2R3A A;  5JHN A;  3SW9 A;  4JLG A;  5CCM A;  4QEP A;  3MO0 A;  5EG2 A;  1N3J A;  3OS5 A;  3CBM A;  3MO5 A;  4JDS A;  3M58 A;  3MO2 A;  4IJ8 A;  5KJN A;  4MI0 A;  5HQ8 A;  3VV0 A;  4YPA A;  4YND A;  3CBO A;  4WUY A;  2QPW A;  3F9Y A;  5F6L A;  1O9S A;  1XQH A;  2RFI A;  5LSZ A;  5TEG A;  3F9X A;  3F9Z A;  5EX3 A;  3RJW A;  3HNA A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...