4MI0A

Human enhancer of zeste (drosophila) homolog 2(ezh2)
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
210
structure length
208
Chain Sequence
YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EZH2
publication title Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
pubmed doi rcsb
source organism Homo sapiens
total genus 46
structure length 208
sequence length 210
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF18264 preSET_CXC CXC domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4mi0A00
3OPEA 2R3AA 4JLGA 4J7IA 3M59A 3TG4A 5HI7A 4YNDA 5T0KA 3S7FA 4C1QA 4WUYA 1N6CA 2O8JA 3TG5A 5KJKA 3BO5A 3OXFA 5KJMA 5F6KC 3VV0A 5LSZA 1ZKKA 3RQ4A 4YNMA 4YPEA 4O6FA 4I51A 5ARGA 3QWWA 1ML9A 4J7FA 1O9SA 3KMJA 3F9ZA 5JIYA 1MVXA 3QWVA 3DB5A 4LDGA 4AU7A 4YPUA 5EX0A 1MUFA 5TTFA 5JINA 1N3JA 3RJWA 3N71A 3RU0A 5JJ0A 3F9WA 4E47A 2JV0A 4Z4PA 3M56A 3MO5A 4QEPA 5EG2A 3QWPA 2W5ZA 3OOIA 3RAYA 3CBMA 5TH7A 3EP0A 3M53A 3IHXA 4IJ8A 4NVQA 5F6LA 3FPDA 2W5YA 3OS5A 1N6AA 5EX3A 3M5AA 3CBPA 2F69A 3KMTA 1PEGA 3M58A 4QENA 5F59A 1XQHA 5CPRB 3DALA 3MO2A 1MVHA 1H3IA 3K5KA 5CCMA 5T0MA 3S7BA 4J83A 3MEKA 4J8OA 3OXGA 4RZ0A 5LSXA 5ARFA 5TEGA 4IJDA 4H12A 4JDSA 4QEOA 3VUZA 3M57A 3S7DA 3F9YA 3F9XA 3RIBA 3CBOA 2BQZA 3SWCA 3S7JA 4MI0A 4FMUA 4O30A 2QPWA 3M55A 5HQ8A 3KMAA 3S8PA 3HNAA 3M54A 2G46A 1MT6A 4MI5A 5JHNA 3PDNA 5F5EA 4BUPA 2IGQA 2RFIA 4NJ5A 5AYFA 3MO0A 4YNPA 5KJNA 3OXLA 5KJLA 3SW9A 4YPAA 5T5GA 5CCLA
chains in the Genus database with same CATH superfamily
3OPEA 2R3AA 4JLGA 4J7IA 3M59A 3TG4A 5HI7A 4YNDA 5T0KA 3S7FA 4C1QA 4WUYA 1N6CA 2O8JA 3TG5A 5KJKA 3BO5A 3OXFA 5KJMA 5F6KC 3VV0A 5LSZA 1ZKKA 3RQ4A 4YNMA 4YPEA 4O6FA 4I51A 5ARGA 3QWWA 1ML9A 4J7FA 1O9SA 3KMJA 3F9ZA 5JIYA 1MVXA 3QWVA 3DB5A 4LDGA 4AU7A 4YPUA 5EX0A 1MUFA 5TTFA 5JINA 1N3JA 3RJWA 3N71A 3RU0A 5JJ0A 3F9WA 4E47A 2JV0A 4Z4PA 3M56A 3MO5A 4QEPA 5EG2A 3QWPA 2W5ZA 3OOIA 3RAYA 3CBMA 5TH7A 3EP0A 3M53A 3IHXA 4IJ8A 4NVQA 5F6LA 3FPDA 2W5YA 3OS5A 1N6AA 5EX3A 3M5AA 3CBPA 2F69A 3KMTA 1PEGA 3M58A 4QENA 5F59A 1XQHA 5CPRB 3DALA 3MO2A 1MVHA 1H3IA 3K5KA 5CCMA 5T0MA 3S7BA 4J83A 3MEKA 4J8OA 3OXGA 4RZ0A 5LSXA 5ARFA 5TEGA 4IJDA 4H12A 4JDSA 4QEOA 3VUZA 3M57A 3S7DA 3F9YA 3F9XA 3RIBA 3CBOA 2BQZA 3SWCA 3S7JA 4MI0A 4FMUA 4O30A 2QPWA 3M55A 5HQ8A 3KMAA 3S8PA 3HNAA 3M54A 2G46A 1MT6A 4MI5A 5JHNA 3PDNA 5F5EA 4BUPA 2IGQA 2RFIA 4NJ5A 5AYFA 3MO0A 4YNPA 5KJNA 3OXLA 5KJLA 3SW9A 4YPAA 5T5GA 5CCLA
chains in the Genus database with same CATH topology
3OPEA 2R3AA 4JLGA 4J7IA 3M59A 3TG4A 5HI7A 4YNDA 5T0KA 3S7FA 4C1QA 4WUYA 1N6CA 2O8JA 3TG5A 5KJKA 3BO5A 3OXFA 5KJMA 5F6KC 3VV0A 5LSZA 1ZKKA 3RQ4A 4YNMA 4YPEA 4O6FA 4I51A 5ARGA 3QWWA 1ML9A 4J7FA 1O9SA 3KMJA 3F9ZA 5JIYA 1MVXA 3QWVA 3DB5A 4LDGA 4AU7A 4YPUA 5EX0A 1MUFA 5TTFA 5JINA 1N3JA 3RJWA 3N71A 3RU0A 5JJ0A 3F9WA 4E47A 2JV0A 4Z4PA 3M56A 3MO5A 4QEPA 5EG2A 3QWPA 2W5ZA 3OOIA 3RAYA 3CBMA 5TH7A 3EP0A 3M53A 3IHXA 4IJ8A 4NVQA 5F6LA 3FPDA 2W5YA 3OS5A 1N6AA 5EX3A 3M5AA 3CBPA 2F69A 3KMTA 1PEGA 3M58A 4QENA 5F59A 1XQHA 5CPRB 3DALA 3MO2A 1MVHA 1H3IA 3K5KA 5CCMA 5T0MA 3S7BA 4J83A 3MEKA 4J8OA 3OXGA 4RZ0A 5LSXA 5ARFA 5TEGA 4IJDA 4H12A 4JDSA 4QEOA 3VUZA 3M57A 3S7DA 3F9YA 3F9XA 3RIBA 3CBOA 2BQZA 3SWCA 3S7JA 4MI0A 4FMUA 4O30A 2QPWA 3M55A 5HQ8A 3KMAA 3S8PA 3HNAA 3M54A 2G46A 1MT6A 4MI5A 5JHNA 3PDNA 5F5EA 4BUPA 2IGQA 2RFIA 4NJ5A 5AYFA 3MO0A 4YNPA 5KJNA 3OXLA 5KJLA 3SW9A 4YPAA 5T5GA 5CCLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OPE A;  2R3A A;  4JLG A;  4J7I A;  3M59 A;  3TG4 A;  5HI7 A;  4YND A;  5T0K A;  3S7F A;  4C1Q A;  4WUY A;  1N6C A;  2O8J A;  3TG5 A;  5KJK A;  3BO5 A;  3OXF A;  5KJM A;  5F6K C;  3VV0 A;  5LSZ A;  1ZKK A;  3RQ4 A;  4YNM A;  4YPE A;  4O6F A;  4I51 A;  5ARG A;  3QWW A;  1ML9 A;  4J7F A;  1O9S A;  3KMJ A;  3F9Z A;  5JIY A;  1MVX A;  3QWV A;  3DB5 A;  4LDG A;  4AU7 A;  4YPU A;  5EX0 A;  1MUF A;  5TTF A;  5JIN A;  1N3J A;  3RJW A;  3N71 A;  3RU0 A;  5JJ0 A;  3F9W A;  4E47 A;  2JV0 A;  4Z4P A;  3M56 A;  3MO5 A;  4QEP A;  5EG2 A;  3QWP A;  2W5Z A;  3OOI A;  3RAY A;  3CBM A;  5TH7 A;  3EP0 A;  3M53 A;  3IHX A;  4IJ8 A;  4NVQ A;  5F6L A;  3FPD A;  2W5Y A;  3OS5 A;  1N6A A;  5EX3 A;  3M5A A;  3CBP A;  2F69 A;  3KMT A;  1PEG A;  3M58 A;  4QEN A;  5F59 A;  1XQH A;  5CPR B;  3DAL A;  3MO2 A;  1MVH A;  1H3I A;  3K5K A;  5CCM A;  5T0M A;  3S7B A;  4J83 A;  3MEK A;  4J8O A;  3OXG A;  4RZ0 A;  5LSX A;  5ARF A;  5TEG A;  4IJD A;  4H12 A;  4JDS A;  4QEO A;  3VUZ A;  3M57 A;  3S7D A;  3F9Y A;  3F9X A;  3RIB A;  3CBO A;  2BQZ A;  3SWC A;  3S7J A;  4MI0 A;  4FMU A;  4O30 A;  2QPW A;  3M55 A;  5HQ8 A;  3KMA A;  3S8P A;  3HNA A;  3M54 A;  2G46 A;  1MT6 A;  4MI5 A;  5JHN A;  3PDN A;  5F5E A;  4BUP A;  2IGQ A;  2RFI A;  4NJ5 A;  5AYF A;  3MO0 A;  4YNP A;  5KJN A;  3OXL A;  5KJL A;  3SW9 A;  4YPA A;  5T5G A;  5CCL A; 
#chains in the Genus database with same CATH topology
 3OPE A;  2R3A A;  4JLG A;  4J7I A;  3M59 A;  3TG4 A;  5HI7 A;  4YND A;  5T0K A;  3S7F A;  4C1Q A;  4WUY A;  1N6C A;  2O8J A;  3TG5 A;  5KJK A;  3BO5 A;  3OXF A;  5KJM A;  5F6K C;  3VV0 A;  5LSZ A;  1ZKK A;  3RQ4 A;  4YNM A;  4YPE A;  4O6F A;  4I51 A;  5ARG A;  3QWW A;  1ML9 A;  4J7F A;  1O9S A;  3KMJ A;  3F9Z A;  5JIY A;  1MVX A;  3QWV A;  3DB5 A;  4LDG A;  4AU7 A;  4YPU A;  5EX0 A;  1MUF A;  5TTF A;  5JIN A;  1N3J A;  3RJW A;  3N71 A;  3RU0 A;  5JJ0 A;  3F9W A;  4E47 A;  2JV0 A;  4Z4P A;  3M56 A;  3MO5 A;  4QEP A;  5EG2 A;  3QWP A;  2W5Z A;  3OOI A;  3RAY A;  3CBM A;  5TH7 A;  3EP0 A;  3M53 A;  3IHX A;  4IJ8 A;  4NVQ A;  5F6L A;  3FPD A;  2W5Y A;  3OS5 A;  1N6A A;  5EX3 A;  3M5A A;  3CBP A;  2F69 A;  3KMT A;  1PEG A;  3M58 A;  4QEN A;  5F59 A;  1XQH A;  5CPR B;  3DAL A;  3MO2 A;  1MVH A;  1H3I A;  3K5K A;  5CCM A;  5T0M A;  3S7B A;  4J83 A;  3MEK A;  4J8O A;  3OXG A;  4RZ0 A;  5LSX A;  5ARF A;  5TEG A;  4IJD A;  4H12 A;  4JDS A;  4QEO A;  3VUZ A;  3M57 A;  3S7D A;  3F9Y A;  3F9X A;  3RIB A;  3CBO A;  2BQZ A;  3SWC A;  3S7J A;  4MI0 A;  4FMU A;  4O30 A;  2QPW A;  3M55 A;  5HQ8 A;  3KMA A;  3S8P A;  3HNA A;  3M54 A;  2G46 A;  1MT6 A;  4MI5 A;  5JHN A;  3PDN A;  5F5E A;  4BUP A;  2IGQ A;  2RFI A;  4NJ5 A;  5AYF A;  3MO0 A;  4YNP A;  5KJN A;  3OXL A;  5KJL A;  3SW9 A;  4YPA A;  5T5G A;  5CCL A; 
#chains in the Genus database with same CATH homology
 3OPE A;  2R3A A;  4JLG A;  4J7I A;  3M59 A;  3TG4 A;  5HI7 A;  4YND A;  5T0K A;  3S7F A;  4C1Q A;  4WUY A;  1N6C A;  2O8J A;  3TG5 A;  5KJK A;  3BO5 A;  3OXF A;  5KJM A;  5F6K C;  3VV0 A;  5LSZ A;  1ZKK A;  3RQ4 A;  4YNM A;  4YPE A;  4O6F A;  4I51 A;  5ARG A;  3QWW A;  1ML9 A;  4J7F A;  1O9S A;  3KMJ A;  3F9Z A;  5JIY A;  1MVX A;  3QWV A;  3DB5 A;  4LDG A;  4AU7 A;  4YPU A;  5EX0 A;  1MUF A;  5TTF A;  5JIN A;  1N3J A;  3RJW A;  3N71 A;  3RU0 A;  5JJ0 A;  3F9W A;  4E47 A;  2JV0 A;  4Z4P A;  3M56 A;  3MO5 A;  4QEP A;  5EG2 A;  3QWP A;  2W5Z A;  3OOI A;  3RAY A;  3CBM A;  5TH7 A;  3EP0 A;  3M53 A;  3IHX A;  4IJ8 A;  4NVQ A;  5F6L A;  3FPD A;  2W5Y A;  3OS5 A;  1N6A A;  5EX3 A;  3M5A A;  3CBP A;  2F69 A;  3KMT A;  1PEG A;  3M58 A;  4QEN A;  5F59 A;  1XQH A;  5CPR B;  3DAL A;  3MO2 A;  1MVH A;  1H3I A;  3K5K A;  5CCM A;  5T0M A;  3S7B A;  4J83 A;  3MEK A;  4J8O A;  3OXG A;  4RZ0 A;  5LSX A;  5ARF A;  5TEG A;  4IJD A;  4H12 A;  4JDS A;  4QEO A;  3VUZ A;  3M57 A;  3S7D A;  3F9Y A;  3F9X A;  3RIB A;  3CBO A;  2BQZ A;  3SWC A;  3S7J A;  4MI0 A;  4FMU A;  4O30 A;  2QPW A;  3M55 A;  5HQ8 A;  3KMA A;  3S8P A;  3HNA A;  3M54 A;  2G46 A;  1MT6 A;  4MI5 A;  5JHN A;  3PDN A;  5F5E A;  4BUP A;  2IGQ A;  2RFI A;  4NJ5 A;  5AYF A;  3MO0 A;  4YNP A;  5KJN A;  3OXL A;  5KJL A;  3SW9 A;  4YPA A;  5T5G A;  5CCL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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