5JJ0A

Structure of g9a set-domain with histone h3k9m peptide and excess sah
Total Genus 76
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 76
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jj0A00
4QENA 3S8PA 5CCMA 4J8OA 5AYFA 4J7IA 3KMTA 3BO5A 5KJMA 2W5ZA 3PDNA 3RJWA 1MT6A 1N6CA 3IHXA 4H12A 3F9YA 5ARFA 5HI7A 1H3IA 3S7BA 5EX3A 5T0MA 3M56A 5LSZA 3S7FA 3VV0A 1MVXA 5CPRB 1PEGA 3MO5A 3M54A 3RIBA 4O30A 5HQ8A 3OPEA 3K5KA 3EP0A 3M53A 4YPEA 3S7DA 3QWWA 1MUFA 3CBPA 3TG4A 4C1QA 3F9WA 5T0KA 3M55A 3M57A 2G46A 3KMJA 2BQZA 5TEGA 4J83A 1N6AA 3CBOA 4YPUA 5CCLA 4YNMA 4MI5A 3OXGA 5ARGA 4QEPA 2R3AA 4IJ8A 3SW9A 4I51A 5TH7A 2F69A 3MEKA 3DALA 4J7FA 1XQHA 3OS5A 3RU0A 3RAYA 3M59A 4JLGA 5F6LA 2JV0A 4AU7A 5F59A 2O8JA 3F9XA 3CBMA 3MO2A 5JIYA 5KJLA 1N3JA 3RQ4A 1MVHA 4MI0A 3OXFA 3FPDA 1ML9A 5KJKA 4IJDA 4RZ0A 5F5EA 2IGQA 5F6KC 4FMUA 4BUPA 5JHNA 3OXLA 5T5GA 4Z4PA 4LDGA 3SWCA 3QWVA 3M58A 3QWPA 3OOIA 4O6FA 5TTFA 4YNDA 3TG5A 4YNPA 1ZKKA 2W5YA 3N71A 5KJNA 4WUYA 1O9SA 4E47A 2RFIA 3VUZA 5EG2A 3KMAA 2QPWA 5LSXA 3DB5A 4QEOA 3M5AA 4JDSA 5EX0A 5JINA 5JJ0A 4NJ5A 3HNAA 4YPAA 3MO0A 4NVQA 3F9ZA 3S7JA
chains in the Genus database with same CATH superfamily
4QENA 3S8PA 5CCMA 4J8OA 5AYFA 4J7IA 3KMTA 3BO5A 5KJMA 2W5ZA 3PDNA 3RJWA 1MT6A 1N6CA 3IHXA 4H12A 3F9YA 5ARFA 5HI7A 1H3IA 3S7BA 5EX3A 5T0MA 3M56A 5LSZA 3S7FA 3VV0A 1MVXA 5CPRB 1PEGA 3MO5A 3M54A 3RIBA 4O30A 5HQ8A 3OPEA 3K5KA 3EP0A 3M53A 4YPEA 3S7DA 3QWWA 1MUFA 3CBPA 3TG4A 4C1QA 3F9WA 5T0KA 3M55A 3M57A 2G46A 3KMJA 2BQZA 5TEGA 4J83A 1N6AA 3CBOA 4YPUA 5CCLA 4YNMA 4MI5A 3OXGA 5ARGA 4QEPA 2R3AA 4IJ8A 3SW9A 4I51A 5TH7A 2F69A 3MEKA 3DALA 4J7FA 1XQHA 3OS5A 3RU0A 3RAYA 3M59A 4JLGA 5F6LA 2JV0A 4AU7A 5F59A 2O8JA 3F9XA 3CBMA 3MO2A 5JIYA 5KJLA 1N3JA 3RQ4A 1MVHA 4MI0A 3OXFA 3FPDA 1ML9A 5KJKA 4IJDA 4RZ0A 5F5EA 2IGQA 5F6KC 4FMUA 4BUPA 5JHNA 3OXLA 5T5GA 4Z4PA 4LDGA 3SWCA 3QWVA 3M58A 3QWPA 3OOIA 4O6FA 5TTFA 4YNDA 3TG5A 4YNPA 1ZKKA 2W5YA 3N71A 5KJNA 4WUYA 1O9SA 4E47A 2RFIA 3VUZA 5EG2A 3KMAA 2QPWA 5LSXA 3DB5A 4QEOA 3M5AA 4JDSA 5EX0A 5JINA 5JJ0A 4NJ5A 3HNAA 4YPAA 3MO0A 4NVQA 3F9ZA 3S7JA
chains in the Genus database with same CATH topology
4QENA 3S8PA 5CCMA 4J8OA 5AYFA 4J7IA 3KMTA 3BO5A 5KJMA 2W5ZA 3PDNA 3RJWA 1MT6A 1N6CA 3IHXA 4H12A 3F9YA 5ARFA 5HI7A 1H3IA 3S7BA 5EX3A 5T0MA 3M56A 5LSZA 3S7FA 3VV0A 1MVXA 5CPRB 1PEGA 3MO5A 3M54A 3RIBA 4O30A 5HQ8A 3OPEA 3K5KA 3EP0A 3M53A 4YPEA 3S7DA 3QWWA 1MUFA 3CBPA 3TG4A 4C1QA 3F9WA 5T0KA 3M55A 3M57A 2G46A 3KMJA 2BQZA 5TEGA 4J83A 1N6AA 3CBOA 4YPUA 5CCLA 4YNMA 4MI5A 3OXGA 5ARGA 4QEPA 2R3AA 4IJ8A 3SW9A 4I51A 5TH7A 2F69A 3MEKA 3DALA 4J7FA 1XQHA 3OS5A 3RU0A 3RAYA 3M59A 4JLGA 5F6LA 2JV0A 4AU7A 5F59A 2O8JA 3F9XA 3CBMA 3MO2A 5JIYA 5KJLA 1N3JA 3RQ4A 1MVHA 4MI0A 3OXFA 3FPDA 1ML9A 5KJKA 4IJDA 4RZ0A 5F5EA 2IGQA 5F6KC 4FMUA 4BUPA 5JHNA 3OXLA 5T5GA 4Z4PA 4LDGA 3SWCA 3QWVA 3M58A 3QWPA 3OOIA 4O6FA 5TTFA 4YNDA 3TG5A 4YNPA 1ZKKA 2W5YA 3N71A 5KJNA 4WUYA 1O9SA 4E47A 2RFIA 3VUZA 5EG2A 3KMAA 2QPWA 5LSXA 3DB5A 4QEOA 3M5AA 4JDSA 5EX0A 5JINA 5JJ0A 4NJ5A 3HNAA 4YPAA 3MO0A 4NVQA 3F9ZA 3S7JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QEN A;  3S8P A;  5CCM A;  4J8O A;  5AYF A;  4J7I A;  3KMT A;  3BO5 A;  5KJM A;  2W5Z A;  3PDN A;  3RJW A;  1MT6 A;  1N6C A;  3IHX A;  4H12 A;  3F9Y A;  5ARF A;  5HI7 A;  1H3I A;  3S7B A;  5EX3 A;  5T0M A;  3M56 A;  5LSZ A;  3S7F A;  3VV0 A;  1MVX A;  5CPR B;  1PEG A;  3MO5 A;  3M54 A;  3RIB A;  4O30 A;  5HQ8 A;  3OPE A;  3K5K A;  3EP0 A;  3M53 A;  4YPE A;  3S7D A;  3QWW A;  1MUF A;  3CBP A;  3TG4 A;  4C1Q A;  3F9W A;  5T0K A;  3M55 A;  3M57 A;  2G46 A;  3KMJ A;  2BQZ A;  5TEG A;  4J83 A;  1N6A A;  3CBO A;  4YPU A;  5CCL A;  4YNM A;  4MI5 A;  3OXG A;  5ARG A;  4QEP A;  2R3A A;  4IJ8 A;  3SW9 A;  4I51 A;  5TH7 A;  2F69 A;  3MEK A;  3DAL A;  4J7F A;  1XQH A;  3OS5 A;  3RU0 A;  3RAY A;  3M59 A;  4JLG A;  5F6L A;  2JV0 A;  4AU7 A;  5F59 A;  2O8J A;  3F9X A;  3CBM A;  3MO2 A;  5JIY A;  5KJL A;  1N3J A;  3RQ4 A;  1MVH A;  4MI0 A;  3OXF A;  3FPD A;  1ML9 A;  5KJK A;  4IJD A;  4RZ0 A;  5F5E A;  2IGQ A;  5F6K C;  4FMU A;  4BUP A;  5JHN A;  3OXL A;  5T5G A;  4Z4P A;  4LDG A;  3SWC A;  3QWV A;  3M58 A;  3QWP A;  3OOI A;  4O6F A;  5TTF A;  4YND A;  3TG5 A;  4YNP A;  1ZKK A;  2W5Y A;  3N71 A;  5KJN A;  4WUY A;  1O9S A;  4E47 A;  2RFI A;  3VUZ A;  5EG2 A;  3KMA A;  2QPW A;  5LSX A;  3DB5 A;  4QEO A;  3M5A A;  4JDS A;  5EX0 A;  5JIN A;  5JJ0 A;  4NJ5 A;  3HNA A;  4YPA A;  3MO0 A;  4NVQ A;  3F9Z A;  3S7J A; 
#chains in the Genus database with same CATH topology
 4QEN A;  3S8P A;  5CCM A;  4J8O A;  5AYF A;  4J7I A;  3KMT A;  3BO5 A;  5KJM A;  2W5Z A;  3PDN A;  3RJW A;  1MT6 A;  1N6C A;  3IHX A;  4H12 A;  3F9Y A;  5ARF A;  5HI7 A;  1H3I A;  3S7B A;  5EX3 A;  5T0M A;  3M56 A;  5LSZ A;  3S7F A;  3VV0 A;  1MVX A;  5CPR B;  1PEG A;  3MO5 A;  3M54 A;  3RIB A;  4O30 A;  5HQ8 A;  3OPE A;  3K5K A;  3EP0 A;  3M53 A;  4YPE A;  3S7D A;  3QWW A;  1MUF A;  3CBP A;  3TG4 A;  4C1Q A;  3F9W A;  5T0K A;  3M55 A;  3M57 A;  2G46 A;  3KMJ A;  2BQZ A;  5TEG A;  4J83 A;  1N6A A;  3CBO A;  4YPU A;  5CCL A;  4YNM A;  4MI5 A;  3OXG A;  5ARG A;  4QEP A;  2R3A A;  4IJ8 A;  3SW9 A;  4I51 A;  5TH7 A;  2F69 A;  3MEK A;  3DAL A;  4J7F A;  1XQH A;  3OS5 A;  3RU0 A;  3RAY A;  3M59 A;  4JLG A;  5F6L A;  2JV0 A;  4AU7 A;  5F59 A;  2O8J A;  3F9X A;  3CBM A;  3MO2 A;  5JIY A;  5KJL A;  1N3J A;  3RQ4 A;  1MVH A;  4MI0 A;  3OXF A;  3FPD A;  1ML9 A;  5KJK A;  4IJD A;  4RZ0 A;  5F5E A;  2IGQ A;  5F6K C;  4FMU A;  4BUP A;  5JHN A;  3OXL A;  5T5G A;  4Z4P A;  4LDG A;  3SWC A;  3QWV A;  3M58 A;  3QWP A;  3OOI A;  4O6F A;  5TTF A;  4YND A;  3TG5 A;  4YNP A;  1ZKK A;  2W5Y A;  3N71 A;  5KJN A;  4WUY A;  1O9S A;  4E47 A;  2RFI A;  3VUZ A;  5EG2 A;  3KMA A;  2QPW A;  5LSX A;  3DB5 A;  4QEO A;  3M5A A;  4JDS A;  5EX0 A;  5JIN A;  5JJ0 A;  4NJ5 A;  3HNA A;  4YPA A;  3MO0 A;  4NVQ A;  3F9Z A;  3S7J A; 
#chains in the Genus database with same CATH homology
 4QEN A;  3S8P A;  5CCM A;  4J8O A;  5AYF A;  4J7I A;  3KMT A;  3BO5 A;  5KJM A;  2W5Z A;  3PDN A;  3RJW A;  1MT6 A;  1N6C A;  3IHX A;  4H12 A;  3F9Y A;  5ARF A;  5HI7 A;  1H3I A;  3S7B A;  5EX3 A;  5T0M A;  3M56 A;  5LSZ A;  3S7F A;  3VV0 A;  1MVX A;  5CPR B;  1PEG A;  3MO5 A;  3M54 A;  3RIB A;  4O30 A;  5HQ8 A;  3OPE A;  3K5K A;  3EP0 A;  3M53 A;  4YPE A;  3S7D A;  3QWW A;  1MUF A;  3CBP A;  3TG4 A;  4C1Q A;  3F9W A;  5T0K A;  3M55 A;  3M57 A;  2G46 A;  3KMJ A;  2BQZ A;  5TEG A;  4J83 A;  1N6A A;  3CBO A;  4YPU A;  5CCL A;  4YNM A;  4MI5 A;  3OXG A;  5ARG A;  4QEP A;  2R3A A;  4IJ8 A;  3SW9 A;  4I51 A;  5TH7 A;  2F69 A;  3MEK A;  3DAL A;  4J7F A;  1XQH A;  3OS5 A;  3RU0 A;  3RAY A;  3M59 A;  4JLG A;  5F6L A;  2JV0 A;  4AU7 A;  5F59 A;  2O8J A;  3F9X A;  3CBM A;  3MO2 A;  5JIY A;  5KJL A;  1N3J A;  3RQ4 A;  1MVH A;  4MI0 A;  3OXF A;  3FPD A;  1ML9 A;  5KJK A;  4IJD A;  4RZ0 A;  5F5E A;  2IGQ A;  5F6K C;  4FMU A;  4BUP A;  5JHN A;  3OXL A;  5T5G A;  4Z4P A;  4LDG A;  3SWC A;  3QWV A;  3M58 A;  3QWP A;  3OOI A;  4O6F A;  5TTF A;  4YND A;  3TG5 A;  4YNP A;  1ZKK A;  2W5Y A;  3N71 A;  5KJN A;  4WUY A;  1O9S A;  4E47 A;  2RFI A;  3VUZ A;  5EG2 A;  3KMA A;  2QPW A;  5LSX A;  3DB5 A;  4QEO A;  3M5A A;  4JDS A;  5EX0 A;  5JIN A;  5JJ0 A;  4NJ5 A;  3HNA A;  4YPA A;  3MO0 A;  4NVQ A;  3F9Z A;  3S7J A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...