5JJ0A

Structure of g9a set-domain with histone h3k9m peptide and excess sah
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 76
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jj0A00
3DB5A 5T0KA 1XQHA 3M55A 4RZ0A 3QWPA 5KJNA 4YNPA 4IJDA 4QEOA 5KJMA 5LSZA 5EX0A 1H3IA 3MO0A 2BQZA 4YPUA 5F59A 4JDSA 3RJWA 3OS5A 4FMUA 3OXLA 4J8OA 2W5ZA 5AYFA 4YPAA 3KMJA 3HNAA 3SW9A 3S7FA 1MVXA 3DALA 5CCMA 4YNDA 3QWVA 4E47A 5F6KC 4JLGA 3OOIA 5LSXA 5JHNA 5HQ8A 3SWCA 4C1QA 3CBPA 4O6FA 4YNMA 5JINA 4NVQA 5F6LA 3S7BA 1N3JA 4LDGA 3S7JA 5TEGA 3M5AA 4J83A 4MI5A 4YPEA 3VUZA 2F69A 5EG2A 3PDNA 1MVHA 5T0MA 3OXFA 2IGQA 2O8JA 5TH7A 3F9ZA 4O30A 4NJ5A 3F9YA 3S8PA 3M57A 2W5YA 2G46A 3TG5A 3MEKA 1ML9A 4BUPA 3M58A 5JJ0A 4QEPA 1N6AA 2QPWA 5F5EA 3F9XA 3QWWA 4H12A 4IJ8A 2JV0A 3MO2A 1MUFA 3KMTA 4I51A 1ZKKA 2R3AA 4WUYA 3M59A 3CBMA 3N71A 1MT6A 5ARGA 5KJLA 3RAYA 4QENA 3CBOA 4MI0A 5KJKA 3S7DA 3TG4A 5CCLA 3RU0A 1PEGA 5ARFA 3M53A 5EX3A 3M56A 3VV0A 1N6CA 3MO5A 3IHXA 4Z4PA 3KMAA 4AU7A 3EP0A 3OPEA 3RQ4A 4J7FA 5JIYA 5T5GA 1O9SA 5TTFA 3F9WA 3BO5A 3FPDA 5CPRB 2RFIA 5HI7A 3OXGA 3K5KA 3M54A 3RIBA 4J7IA
chains in the Genus database with same CATH superfamily
3DB5A 5T0KA 1XQHA 3M55A 4RZ0A 3QWPA 5KJNA 4YNPA 4IJDA 4QEOA 5KJMA 5LSZA 5EX0A 1H3IA 3MO0A 2BQZA 4YPUA 5F59A 4JDSA 3RJWA 3OS5A 4FMUA 3OXLA 4J8OA 2W5ZA 5AYFA 4YPAA 3KMJA 3HNAA 3SW9A 3S7FA 1MVXA 3DALA 5CCMA 4YNDA 3QWVA 4E47A 5F6KC 4JLGA 3OOIA 5LSXA 5JHNA 5HQ8A 3SWCA 4C1QA 3CBPA 4O6FA 4YNMA 5JINA 4NVQA 5F6LA 3S7BA 1N3JA 4LDGA 3S7JA 5TEGA 3M5AA 4J83A 4MI5A 4YPEA 3VUZA 2F69A 5EG2A 3PDNA 1MVHA 5T0MA 3OXFA 2IGQA 2O8JA 5TH7A 3F9ZA 4O30A 4NJ5A 3F9YA 3S8PA 3M57A 2W5YA 2G46A 3TG5A 3MEKA 1ML9A 4BUPA 3M58A 5JJ0A 4QEPA 1N6AA 2QPWA 5F5EA 3F9XA 3QWWA 4H12A 4IJ8A 2JV0A 3MO2A 1MUFA 3KMTA 4I51A 1ZKKA 2R3AA 4WUYA 3M59A 3CBMA 3N71A 1MT6A 5ARGA 5KJLA 3RAYA 4QENA 3CBOA 4MI0A 5KJKA 3S7DA 3TG4A 5CCLA 3RU0A 1PEGA 5ARFA 3M53A 5EX3A 3M56A 3VV0A 1N6CA 3MO5A 3IHXA 4Z4PA 3KMAA 4AU7A 3EP0A 3OPEA 3RQ4A 4J7FA 5JIYA 5T5GA 1O9SA 5TTFA 3F9WA 3BO5A 3FPDA 5CPRB 2RFIA 5HI7A 3OXGA 3K5KA 3M54A 3RIBA 4J7IA
chains in the Genus database with same CATH topology
3DB5A 5T0KA 1XQHA 3M55A 4RZ0A 3QWPA 5KJNA 4YNPA 4IJDA 4QEOA 5KJMA 5LSZA 5EX0A 1H3IA 3MO0A 2BQZA 4YPUA 5F59A 4JDSA 3RJWA 3OS5A 4FMUA 3OXLA 4J8OA 2W5ZA 5AYFA 4YPAA 3KMJA 3HNAA 3SW9A 3S7FA 1MVXA 3DALA 5CCMA 4YNDA 3QWVA 4E47A 5F6KC 4JLGA 3OOIA 5LSXA 5JHNA 5HQ8A 3SWCA 4C1QA 3CBPA 4O6FA 4YNMA 5JINA 4NVQA 5F6LA 3S7BA 1N3JA 4LDGA 3S7JA 5TEGA 3M5AA 4J83A 4MI5A 4YPEA 3VUZA 2F69A 5EG2A 3PDNA 1MVHA 5T0MA 3OXFA 2IGQA 2O8JA 5TH7A 3F9ZA 4O30A 4NJ5A 3F9YA 3S8PA 3M57A 2W5YA 2G46A 3TG5A 3MEKA 1ML9A 4BUPA 3M58A 5JJ0A 4QEPA 1N6AA 2QPWA 5F5EA 3F9XA 3QWWA 4H12A 4IJ8A 2JV0A 3MO2A 1MUFA 3KMTA 4I51A 1ZKKA 2R3AA 4WUYA 3M59A 3CBMA 3N71A 1MT6A 5ARGA 5KJLA 3RAYA 4QENA 3CBOA 4MI0A 5KJKA 3S7DA 3TG4A 5CCLA 3RU0A 1PEGA 5ARFA 3M53A 5EX3A 3M56A 3VV0A 1N6CA 3MO5A 3IHXA 4Z4PA 3KMAA 4AU7A 3EP0A 3OPEA 3RQ4A 4J7FA 5JIYA 5T5GA 1O9SA 5TTFA 3F9WA 3BO5A 3FPDA 5CPRB 2RFIA 5HI7A 3OXGA 3K5KA 3M54A 3RIBA 4J7IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DB5 A;  5T0K A;  1XQH A;  3M55 A;  4RZ0 A;  3QWP A;  5KJN A;  4YNP A;  4IJD A;  4QEO A;  5KJM A;  5LSZ A;  5EX0 A;  1H3I A;  3MO0 A;  2BQZ A;  4YPU A;  5F59 A;  4JDS A;  3RJW A;  3OS5 A;  4FMU A;  3OXL A;  4J8O A;  2W5Z A;  5AYF A;  4YPA A;  3KMJ A;  3HNA A;  3SW9 A;  3S7F A;  1MVX A;  3DAL A;  5CCM A;  4YND A;  3QWV A;  4E47 A;  5F6K C;  4JLG A;  3OOI A;  5LSX A;  5JHN A;  5HQ8 A;  3SWC A;  4C1Q A;  3CBP A;  4O6F A;  4YNM A;  5JIN A;  4NVQ A;  5F6L A;  3S7B A;  1N3J A;  4LDG A;  3S7J A;  5TEG A;  3M5A A;  4J83 A;  4MI5 A;  4YPE A;  3VUZ A;  2F69 A;  5EG2 A;  3PDN A;  1MVH A;  5T0M A;  3OXF A;  2IGQ A;  2O8J A;  5TH7 A;  3F9Z A;  4O30 A;  4NJ5 A;  3F9Y A;  3S8P A;  3M57 A;  2W5Y A;  2G46 A;  3TG5 A;  3MEK A;  1ML9 A;  4BUP A;  3M58 A;  5JJ0 A;  4QEP A;  1N6A A;  2QPW A;  5F5E A;  3F9X A;  3QWW A;  4H12 A;  4IJ8 A;  2JV0 A;  3MO2 A;  1MUF A;  3KMT A;  4I51 A;  1ZKK A;  2R3A A;  4WUY A;  3M59 A;  3CBM A;  3N71 A;  1MT6 A;  5ARG A;  5KJL A;  3RAY A;  4QEN A;  3CBO A;  4MI0 A;  5KJK A;  3S7D A;  3TG4 A;  5CCL A;  3RU0 A;  1PEG A;  5ARF A;  3M53 A;  5EX3 A;  3M56 A;  3VV0 A;  1N6C A;  3MO5 A;  3IHX A;  4Z4P A;  3KMA A;  4AU7 A;  3EP0 A;  3OPE A;  3RQ4 A;  4J7F A;  5JIY A;  5T5G A;  1O9S A;  5TTF A;  3F9W A;  3BO5 A;  3FPD A;  5CPR B;  2RFI A;  5HI7 A;  3OXG A;  3K5K A;  3M54 A;  3RIB A;  4J7I A; 
#chains in the Genus database with same CATH topology
 3DB5 A;  5T0K A;  1XQH A;  3M55 A;  4RZ0 A;  3QWP A;  5KJN A;  4YNP A;  4IJD A;  4QEO A;  5KJM A;  5LSZ A;  5EX0 A;  1H3I A;  3MO0 A;  2BQZ A;  4YPU A;  5F59 A;  4JDS A;  3RJW A;  3OS5 A;  4FMU A;  3OXL A;  4J8O A;  2W5Z A;  5AYF A;  4YPA A;  3KMJ A;  3HNA A;  3SW9 A;  3S7F A;  1MVX A;  3DAL A;  5CCM A;  4YND A;  3QWV A;  4E47 A;  5F6K C;  4JLG A;  3OOI A;  5LSX A;  5JHN A;  5HQ8 A;  3SWC A;  4C1Q A;  3CBP A;  4O6F A;  4YNM A;  5JIN A;  4NVQ A;  5F6L A;  3S7B A;  1N3J A;  4LDG A;  3S7J A;  5TEG A;  3M5A A;  4J83 A;  4MI5 A;  4YPE A;  3VUZ A;  2F69 A;  5EG2 A;  3PDN A;  1MVH A;  5T0M A;  3OXF A;  2IGQ A;  2O8J A;  5TH7 A;  3F9Z A;  4O30 A;  4NJ5 A;  3F9Y A;  3S8P A;  3M57 A;  2W5Y A;  2G46 A;  3TG5 A;  3MEK A;  1ML9 A;  4BUP A;  3M58 A;  5JJ0 A;  4QEP A;  1N6A A;  2QPW A;  5F5E A;  3F9X A;  3QWW A;  4H12 A;  4IJ8 A;  2JV0 A;  3MO2 A;  1MUF A;  3KMT A;  4I51 A;  1ZKK A;  2R3A A;  4WUY A;  3M59 A;  3CBM A;  3N71 A;  1MT6 A;  5ARG A;  5KJL A;  3RAY A;  4QEN A;  3CBO A;  4MI0 A;  5KJK A;  3S7D A;  3TG4 A;  5CCL A;  3RU0 A;  1PEG A;  5ARF A;  3M53 A;  5EX3 A;  3M56 A;  3VV0 A;  1N6C A;  3MO5 A;  3IHX A;  4Z4P A;  3KMA A;  4AU7 A;  3EP0 A;  3OPE A;  3RQ4 A;  4J7F A;  5JIY A;  5T5G A;  1O9S A;  5TTF A;  3F9W A;  3BO5 A;  3FPD A;  5CPR B;  2RFI A;  5HI7 A;  3OXG A;  3K5K A;  3M54 A;  3RIB A;  4J7I A; 
#chains in the Genus database with same CATH homology
 3DB5 A;  5T0K A;  1XQH A;  3M55 A;  4RZ0 A;  3QWP A;  5KJN A;  4YNP A;  4IJD A;  4QEO A;  5KJM A;  5LSZ A;  5EX0 A;  1H3I A;  3MO0 A;  2BQZ A;  4YPU A;  5F59 A;  4JDS A;  3RJW A;  3OS5 A;  4FMU A;  3OXL A;  4J8O A;  2W5Z A;  5AYF A;  4YPA A;  3KMJ A;  3HNA A;  3SW9 A;  3S7F A;  1MVX A;  3DAL A;  5CCM A;  4YND A;  3QWV A;  4E47 A;  5F6K C;  4JLG A;  3OOI A;  5LSX A;  5JHN A;  5HQ8 A;  3SWC A;  4C1Q A;  3CBP A;  4O6F A;  4YNM A;  5JIN A;  4NVQ A;  5F6L A;  3S7B A;  1N3J A;  4LDG A;  3S7J A;  5TEG A;  3M5A A;  4J83 A;  4MI5 A;  4YPE A;  3VUZ A;  2F69 A;  5EG2 A;  3PDN A;  1MVH A;  5T0M A;  3OXF A;  2IGQ A;  2O8J A;  5TH7 A;  3F9Z A;  4O30 A;  4NJ5 A;  3F9Y A;  3S8P A;  3M57 A;  2W5Y A;  2G46 A;  3TG5 A;  3MEK A;  1ML9 A;  4BUP A;  3M58 A;  5JJ0 A;  4QEP A;  1N6A A;  2QPW A;  5F5E A;  3F9X A;  3QWW A;  4H12 A;  4IJ8 A;  2JV0 A;  3MO2 A;  1MUF A;  3KMT A;  4I51 A;  1ZKK A;  2R3A A;  4WUY A;  3M59 A;  3CBM A;  3N71 A;  1MT6 A;  5ARG A;  5KJL A;  3RAY A;  4QEN A;  3CBO A;  4MI0 A;  5KJK A;  3S7D A;  3TG4 A;  5CCL A;  3RU0 A;  1PEG A;  5ARF A;  3M53 A;  5EX3 A;  3M56 A;  3VV0 A;  1N6C A;  3MO5 A;  3IHX A;  4Z4P A;  3KMA A;  4AU7 A;  3EP0 A;  3OPE A;  3RQ4 A;  4J7F A;  5JIY A;  5T5G A;  1O9S A;  5TTF A;  3F9W A;  3BO5 A;  3FPD A;  5CPR B;  2RFI A;  5HI7 A;  3OXG A;  3K5K A;  3M54 A;  3RIB A;  4J7I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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