5JJ0A

Structure of g9a set-domain with histone h3k9m peptide and excess sah
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
total genus 76
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jj0A00
4YNMA 3SW9A 3IHXA 3VUZA 3MEKA 5F6KC 5T5GA 2BQZA 4NJ5A 5CPRB 3OS5A 5ARGA 4WUYA 5EX3A 4J83A 3M53A 4J7IA 3S8PA 3RJWA 4Z4PA 3OXLA 4JDSA 4YPUA 5T0MA 3MO5A 3KMJA 3PDNA 3OPEA 2JV0A 3TG5A 3DB5A 3RAYA 3MO0A 3RQ4A 3F9XA 3RU0A 5KJLA 3HNAA 2W5YA 2QPWA 2F69A 1N6AA 1MUFA 3RIBA 3N71A 4LDGA 5LSXA 1MT6A 4BUPA 5F5EA 5LSZA 4QENA 3K5KA 4YNDA 1XQHA 3OOIA 4E47A 2IGQA 5KJKA 1MVHA 3M55A 4IJDA 3KMTA 5CCLA 4QEOA 2O8JA 4J8OA 3KMAA 3S7BA 5TTFA 4YPEA 5T0KA 5JIYA 3DALA 1H3IA 4O6FA 4MI0A 1MVXA 3FPDA 5TEGA 1ZKKA 3S7FA 4JLGA 3VV0A 3MO2A 4O30A 5F6LA 5ARFA 3M56A 1N6CA 3M59A 4J7FA 5JINA 5AYFA 5JJ0A 3M54A 3M58A 3M57A 3CBOA 5HI7A 2R3AA 3CBMA 4H12A 4C1QA 4FMUA 2G46A 4YNPA 3EP0A 3S7JA 4YPAA 5EX0A 3BO5A 4RZ0A 4NVQA 3TG4A 5HQ8A 3OXFA 5CCMA 3F9ZA 4I51A 4QEPA 2W5ZA 5KJNA 1N3JA 5EG2A 3QWWA 3S7DA 4IJ8A 3SWCA 3QWVA 5KJMA 3F9YA 3OXGA 1O9SA 1PEGA 3F9WA 3CBPA 5F59A 5TH7A 3M5AA 5JHNA 4AU7A 3QWPA 2RFIA 4MI5A 1ML9A
chains in the Genus database with same CATH superfamily
4YNMA 3SW9A 3IHXA 3VUZA 3MEKA 5F6KC 5T5GA 2BQZA 4NJ5A 5CPRB 3OS5A 5ARGA 4WUYA 5EX3A 4J83A 3M53A 4J7IA 3S8PA 3RJWA 4Z4PA 3OXLA 4JDSA 4YPUA 5T0MA 3MO5A 3KMJA 3PDNA 3OPEA 2JV0A 3TG5A 3DB5A 3RAYA 3MO0A 3RQ4A 3F9XA 3RU0A 5KJLA 3HNAA 2W5YA 2QPWA 2F69A 1N6AA 1MUFA 3RIBA 3N71A 4LDGA 5LSXA 1MT6A 4BUPA 5F5EA 5LSZA 4QENA 3K5KA 4YNDA 1XQHA 3OOIA 4E47A 2IGQA 5KJKA 1MVHA 3M55A 4IJDA 3KMTA 5CCLA 4QEOA 2O8JA 4J8OA 3KMAA 3S7BA 5TTFA 4YPEA 5T0KA 5JIYA 3DALA 1H3IA 4O6FA 4MI0A 1MVXA 3FPDA 5TEGA 1ZKKA 3S7FA 4JLGA 3VV0A 3MO2A 4O30A 5F6LA 5ARFA 3M56A 1N6CA 3M59A 4J7FA 5JINA 5AYFA 5JJ0A 3M54A 3M58A 3M57A 3CBOA 5HI7A 2R3AA 3CBMA 4H12A 4C1QA 4FMUA 2G46A 4YNPA 3EP0A 3S7JA 4YPAA 5EX0A 3BO5A 4RZ0A 4NVQA 3TG4A 5HQ8A 3OXFA 5CCMA 3F9ZA 4I51A 4QEPA 2W5ZA 5KJNA 1N3JA 5EG2A 3QWWA 3S7DA 4IJ8A 3SWCA 3QWVA 5KJMA 3F9YA 3OXGA 1O9SA 1PEGA 3F9WA 3CBPA 5F59A 5TH7A 3M5AA 5JHNA 4AU7A 3QWPA 2RFIA 4MI5A 1ML9A
chains in the Genus database with same CATH topology
4YNMA 3SW9A 3IHXA 3VUZA 3MEKA 5F6KC 5T5GA 2BQZA 4NJ5A 5CPRB 3OS5A 5ARGA 4WUYA 5EX3A 4J83A 3M53A 4J7IA 3S8PA 3RJWA 4Z4PA 3OXLA 4JDSA 4YPUA 5T0MA 3MO5A 3KMJA 3PDNA 3OPEA 2JV0A 3TG5A 3DB5A 3RAYA 3MO0A 3RQ4A 3F9XA 3RU0A 5KJLA 3HNAA 2W5YA 2QPWA 2F69A 1N6AA 1MUFA 3RIBA 3N71A 4LDGA 5LSXA 1MT6A 4BUPA 5F5EA 5LSZA 4QENA 3K5KA 4YNDA 1XQHA 3OOIA 4E47A 2IGQA 5KJKA 1MVHA 3M55A 4IJDA 3KMTA 5CCLA 4QEOA 2O8JA 4J8OA 3KMAA 3S7BA 5TTFA 4YPEA 5T0KA 5JIYA 3DALA 1H3IA 4O6FA 4MI0A 1MVXA 3FPDA 5TEGA 1ZKKA 3S7FA 4JLGA 3VV0A 3MO2A 4O30A 5F6LA 5ARFA 3M56A 1N6CA 3M59A 4J7FA 5JINA 5AYFA 5JJ0A 3M54A 3M58A 3M57A 3CBOA 5HI7A 2R3AA 3CBMA 4H12A 4C1QA 4FMUA 2G46A 4YNPA 3EP0A 3S7JA 4YPAA 5EX0A 3BO5A 4RZ0A 4NVQA 3TG4A 5HQ8A 3OXFA 5CCMA 3F9ZA 4I51A 4QEPA 2W5ZA 5KJNA 1N3JA 5EG2A 3QWWA 3S7DA 4IJ8A 3SWCA 3QWVA 5KJMA 3F9YA 3OXGA 1O9SA 1PEGA 3F9WA 3CBPA 5F59A 5TH7A 3M5AA 5JHNA 4AU7A 3QWPA 2RFIA 4MI5A 1ML9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YNM A;  3SW9 A;  3IHX A;  3VUZ A;  3MEK A;  5F6K C;  5T5G A;  2BQZ A;  4NJ5 A;  5CPR B;  3OS5 A;  5ARG A;  4WUY A;  5EX3 A;  4J83 A;  3M53 A;  4J7I A;  3S8P A;  3RJW A;  4Z4P A;  3OXL A;  4JDS A;  4YPU A;  5T0M A;  3MO5 A;  3KMJ A;  3PDN A;  3OPE A;  2JV0 A;  3TG5 A;  3DB5 A;  3RAY A;  3MO0 A;  3RQ4 A;  3F9X A;  3RU0 A;  5KJL A;  3HNA A;  2W5Y A;  2QPW A;  2F69 A;  1N6A A;  1MUF A;  3RIB A;  3N71 A;  4LDG A;  5LSX A;  1MT6 A;  4BUP A;  5F5E A;  5LSZ A;  4QEN A;  3K5K A;  4YND A;  1XQH A;  3OOI A;  4E47 A;  2IGQ A;  5KJK A;  1MVH A;  3M55 A;  4IJD A;  3KMT A;  5CCL A;  4QEO A;  2O8J A;  4J8O A;  3KMA A;  3S7B A;  5TTF A;  4YPE A;  5T0K A;  5JIY A;  3DAL A;  1H3I A;  4O6F A;  4MI0 A;  1MVX A;  3FPD A;  5TEG A;  1ZKK A;  3S7F A;  4JLG A;  3VV0 A;  3MO2 A;  4O30 A;  5F6L A;  5ARF A;  3M56 A;  1N6C A;  3M59 A;  4J7F A;  5JIN A;  5AYF A;  5JJ0 A;  3M54 A;  3M58 A;  3M57 A;  3CBO A;  5HI7 A;  2R3A A;  3CBM A;  4H12 A;  4C1Q A;  4FMU A;  2G46 A;  4YNP A;  3EP0 A;  3S7J A;  4YPA A;  5EX0 A;  3BO5 A;  4RZ0 A;  4NVQ A;  3TG4 A;  5HQ8 A;  3OXF A;  5CCM A;  3F9Z A;  4I51 A;  4QEP A;  2W5Z A;  5KJN A;  1N3J A;  5EG2 A;  3QWW A;  3S7D A;  4IJ8 A;  3SWC A;  3QWV A;  5KJM A;  3F9Y A;  3OXG A;  1O9S A;  1PEG A;  3F9W A;  3CBP A;  5F59 A;  5TH7 A;  3M5A A;  5JHN A;  4AU7 A;  3QWP A;  2RFI A;  4MI5 A;  1ML9 A; 
#chains in the Genus database with same CATH topology
 4YNM A;  3SW9 A;  3IHX A;  3VUZ A;  3MEK A;  5F6K C;  5T5G A;  2BQZ A;  4NJ5 A;  5CPR B;  3OS5 A;  5ARG A;  4WUY A;  5EX3 A;  4J83 A;  3M53 A;  4J7I A;  3S8P A;  3RJW A;  4Z4P A;  3OXL A;  4JDS A;  4YPU A;  5T0M A;  3MO5 A;  3KMJ A;  3PDN A;  3OPE A;  2JV0 A;  3TG5 A;  3DB5 A;  3RAY A;  3MO0 A;  3RQ4 A;  3F9X A;  3RU0 A;  5KJL A;  3HNA A;  2W5Y A;  2QPW A;  2F69 A;  1N6A A;  1MUF A;  3RIB A;  3N71 A;  4LDG A;  5LSX A;  1MT6 A;  4BUP A;  5F5E A;  5LSZ A;  4QEN A;  3K5K A;  4YND A;  1XQH A;  3OOI A;  4E47 A;  2IGQ A;  5KJK A;  1MVH A;  3M55 A;  4IJD A;  3KMT A;  5CCL A;  4QEO A;  2O8J A;  4J8O A;  3KMA A;  3S7B A;  5TTF A;  4YPE A;  5T0K A;  5JIY A;  3DAL A;  1H3I A;  4O6F A;  4MI0 A;  1MVX A;  3FPD A;  5TEG A;  1ZKK A;  3S7F A;  4JLG A;  3VV0 A;  3MO2 A;  4O30 A;  5F6L A;  5ARF A;  3M56 A;  1N6C A;  3M59 A;  4J7F A;  5JIN A;  5AYF A;  5JJ0 A;  3M54 A;  3M58 A;  3M57 A;  3CBO A;  5HI7 A;  2R3A A;  3CBM A;  4H12 A;  4C1Q A;  4FMU A;  2G46 A;  4YNP A;  3EP0 A;  3S7J A;  4YPA A;  5EX0 A;  3BO5 A;  4RZ0 A;  4NVQ A;  3TG4 A;  5HQ8 A;  3OXF A;  5CCM A;  3F9Z A;  4I51 A;  4QEP A;  2W5Z A;  5KJN A;  1N3J A;  5EG2 A;  3QWW A;  3S7D A;  4IJ8 A;  3SWC A;  3QWV A;  5KJM A;  3F9Y A;  3OXG A;  1O9S A;  1PEG A;  3F9W A;  3CBP A;  5F59 A;  5TH7 A;  3M5A A;  5JHN A;  4AU7 A;  3QWP A;  2RFI A;  4MI5 A;  1ML9 A; 
#chains in the Genus database with same CATH homology
 4YNM A;  3SW9 A;  3IHX A;  3VUZ A;  3MEK A;  5F6K C;  5T5G A;  2BQZ A;  4NJ5 A;  5CPR B;  3OS5 A;  5ARG A;  4WUY A;  5EX3 A;  4J83 A;  3M53 A;  4J7I A;  3S8P A;  3RJW A;  4Z4P A;  3OXL A;  4JDS A;  4YPU A;  5T0M A;  3MO5 A;  3KMJ A;  3PDN A;  3OPE A;  2JV0 A;  3TG5 A;  3DB5 A;  3RAY A;  3MO0 A;  3RQ4 A;  3F9X A;  3RU0 A;  5KJL A;  3HNA A;  2W5Y A;  2QPW A;  2F69 A;  1N6A A;  1MUF A;  3RIB A;  3N71 A;  4LDG A;  5LSX A;  1MT6 A;  4BUP A;  5F5E A;  5LSZ A;  4QEN A;  3K5K A;  4YND A;  1XQH A;  3OOI A;  4E47 A;  2IGQ A;  5KJK A;  1MVH A;  3M55 A;  4IJD A;  3KMT A;  5CCL A;  4QEO A;  2O8J A;  4J8O A;  3KMA A;  3S7B A;  5TTF A;  4YPE A;  5T0K A;  5JIY A;  3DAL A;  1H3I A;  4O6F A;  4MI0 A;  1MVX A;  3FPD A;  5TEG A;  1ZKK A;  3S7F A;  4JLG A;  3VV0 A;  3MO2 A;  4O30 A;  5F6L A;  5ARF A;  3M56 A;  1N6C A;  3M59 A;  4J7F A;  5JIN A;  5AYF A;  5JJ0 A;  3M54 A;  3M58 A;  3M57 A;  3CBO A;  5HI7 A;  2R3A A;  3CBM A;  4H12 A;  4C1Q A;  4FMU A;  2G46 A;  4YNP A;  3EP0 A;  3S7J A;  4YPA A;  5EX0 A;  3BO5 A;  4RZ0 A;  4NVQ A;  3TG4 A;  5HQ8 A;  3OXF A;  5CCM A;  3F9Z A;  4I51 A;  4QEP A;  2W5Z A;  5KJN A;  1N3J A;  5EG2 A;  3QWW A;  3S7D A;  4IJ8 A;  3SWC A;  3QWV A;  5KJM A;  3F9Y A;  3OXG A;  1O9S A;  1PEG A;  3F9W A;  3CBP A;  5F59 A;  5TH7 A;  3M5A A;  5JHN A;  4AU7 A;  3QWP A;  2RFI A;  4MI5 A;  1ML9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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