5T0KA

Structure of g9a set-domain with h3k9m mutant peptide and sam
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
268
structure length
264
Chain Sequence
b'KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
molecule tags Transferase
source organism Homo sapiens
publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
total genus 72
structure length 264
sequence length 268
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0kA00
5TH7A 1MT6A 3N71A 1MVXA 2RFIA 3F9ZA 3M56A 3OXFA 3QWWA 1MVHA 2G46A 5KJLA 3M5AA 3MO2A 3MO0A 4QENA 3DALA 5AYFA 3QWVA 4I51A 5CPRB 4YNPA 2O8JA 3EP0A 4WUYA 4NVQA 4AU7A 4J7IA 5KJNA 3S7DA 4MI5A 1H3IA 3F9YA 1O9SA 3F9XA 3M54A 4YPEA 3F9WA 3TG4A 4IJ8A 3VV0A 3DB5A 5KJMA 3CBMA 5KJKA 5F5EA 4RZ0A 3RJWA 3RAYA 3FPDA 2BQZA 2R3AA 5LSXA 5CCMA 1ML9A 4BUPA 1XQHA 3M53A 3VUZA 3MEKA 4FMUA 4MI0A 3M55A 3K5KA 5CCLA 4O30A 3HNAA 3RQ4A 3IHXA 4J8OA 5ARFA 2IGQA 3PDNA 4JDSA 4YPAA 4Z4PA 1N3JA 5T0MA 3RIBA 5F59A 5T5GA 4YNMA 4QEOA 3OPEA 3S8PA 3M58A 3MO5A 3OOIA 1PEGA 4C1QA 5TEGA 5HI7A 4E47A 5EX0A 5JJ0A 5EX3A 5T0KA 1N6AA 4O6FA 2W5YA 3CBPA 5JINA 3TG5A 4YNDA 5TTFA 3QWPA 2JV0A 4LDGA 1MUFA 4J7FA 3KMAA 4YPUA 5HQ8A 3S7BA 4NJ5A 1N6CA 3S7JA 1ZKKA 3CBOA 3KMJA 3KMTA 3BO5A 5F6LA 3M59A 4IJDA 5JIYA 2W5ZA 3OXGA 4QEPA 5EG2A 2QPWA 3RU0A 3M57A 3OS5A 5F6KC 4J83A 5ARGA 4H12A 2F69A 5LSZA 3SWCA 5JHNA 3SW9A 3S7FA 4JLGA 3OXLA
chains in the Genus database with same CATH superfamily
5TH7A 1MT6A 3N71A 1MVXA 2RFIA 3F9ZA 3M56A 3OXFA 3QWWA 1MVHA 2G46A 5KJLA 3M5AA 3MO2A 3MO0A 4QENA 3DALA 5AYFA 3QWVA 4I51A 5CPRB 4YNPA 2O8JA 3EP0A 4WUYA 4NVQA 4AU7A 4J7IA 5KJNA 3S7DA 4MI5A 1H3IA 3F9YA 1O9SA 3F9XA 3M54A 4YPEA 3F9WA 3TG4A 4IJ8A 3VV0A 3DB5A 5KJMA 3CBMA 5KJKA 5F5EA 4RZ0A 3RJWA 3RAYA 3FPDA 2BQZA 2R3AA 5LSXA 5CCMA 1ML9A 4BUPA 1XQHA 3M53A 3VUZA 3MEKA 4FMUA 4MI0A 3M55A 3K5KA 5CCLA 4O30A 3HNAA 3RQ4A 3IHXA 4J8OA 5ARFA 2IGQA 3PDNA 4JDSA 4YPAA 4Z4PA 1N3JA 5T0MA 3RIBA 5F59A 5T5GA 4YNMA 4QEOA 3OPEA 3S8PA 3M58A 3MO5A 3OOIA 1PEGA 4C1QA 5TEGA 5HI7A 4E47A 5EX0A 5JJ0A 5EX3A 5T0KA 1N6AA 4O6FA 2W5YA 3CBPA 5JINA 3TG5A 4YNDA 5TTFA 3QWPA 2JV0A 4LDGA 1MUFA 4J7FA 3KMAA 4YPUA 5HQ8A 3S7BA 4NJ5A 1N6CA 3S7JA 1ZKKA 3CBOA 3KMJA 3KMTA 3BO5A 5F6LA 3M59A 4IJDA 5JIYA 2W5ZA 3OXGA 4QEPA 5EG2A 2QPWA 3RU0A 3M57A 3OS5A 5F6KC 4J83A 5ARGA 4H12A 2F69A 5LSZA 3SWCA 5JHNA 3SW9A 3S7FA 4JLGA 3OXLA
chains in the Genus database with same CATH topology
5TH7A 1MT6A 3N71A 1MVXA 2RFIA 3F9ZA 3M56A 3OXFA 3QWWA 1MVHA 2G46A 5KJLA 3M5AA 3MO2A 3MO0A 4QENA 3DALA 5AYFA 3QWVA 4I51A 5CPRB 4YNPA 2O8JA 3EP0A 4WUYA 4NVQA 4AU7A 4J7IA 5KJNA 3S7DA 4MI5A 1H3IA 3F9YA 1O9SA 3F9XA 3M54A 4YPEA 3F9WA 3TG4A 4IJ8A 3VV0A 3DB5A 5KJMA 3CBMA 5KJKA 5F5EA 4RZ0A 3RJWA 3RAYA 3FPDA 2BQZA 2R3AA 5LSXA 5CCMA 1ML9A 4BUPA 1XQHA 3M53A 3VUZA 3MEKA 4FMUA 4MI0A 3M55A 3K5KA 5CCLA 4O30A 3HNAA 3RQ4A 3IHXA 4J8OA 5ARFA 2IGQA 3PDNA 4JDSA 4YPAA 4Z4PA 1N3JA 5T0MA 3RIBA 5F59A 5T5GA 4YNMA 4QEOA 3OPEA 3S8PA 3M58A 3MO5A 3OOIA 1PEGA 4C1QA 5TEGA 5HI7A 4E47A 5EX0A 5JJ0A 5EX3A 5T0KA 1N6AA 4O6FA 2W5YA 3CBPA 5JINA 3TG5A 4YNDA 5TTFA 3QWPA 2JV0A 4LDGA 1MUFA 4J7FA 3KMAA 4YPUA 5HQ8A 3S7BA 4NJ5A 1N6CA 3S7JA 1ZKKA 3CBOA 3KMJA 3KMTA 3BO5A 5F6LA 3M59A 4IJDA 5JIYA 2W5ZA 3OXGA 4QEPA 5EG2A 2QPWA 3RU0A 3M57A 3OS5A 5F6KC 4J83A 5ARGA 4H12A 2F69A 5LSZA 3SWCA 5JHNA 3SW9A 3S7FA 4JLGA 3OXLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TH7 A;  1MT6 A;  3N71 A;  1MVX A;  2RFI A;  3F9Z A;  3M56 A;  3OXF A;  3QWW A;  1MVH A;  2G46 A;  5KJL A;  3M5A A;  3MO2 A;  3MO0 A;  4QEN A;  3DAL A;  5AYF A;  3QWV A;  4I51 A;  5CPR B;  4YNP A;  2O8J A;  3EP0 A;  4WUY A;  4NVQ A;  4AU7 A;  4J7I A;  5KJN A;  3S7D A;  4MI5 A;  1H3I A;  3F9Y A;  1O9S A;  3F9X A;  3M54 A;  4YPE A;  3F9W A;  3TG4 A;  4IJ8 A;  3VV0 A;  3DB5 A;  5KJM A;  3CBM A;  5KJK A;  5F5E A;  4RZ0 A;  3RJW A;  3RAY A;  3FPD A;  2BQZ A;  2R3A A;  5LSX A;  5CCM A;  1ML9 A;  4BUP A;  1XQH A;  3M53 A;  3VUZ A;  3MEK A;  4FMU A;  4MI0 A;  3M55 A;  3K5K A;  5CCL A;  4O30 A;  3HNA A;  3RQ4 A;  3IHX A;  4J8O A;  5ARF A;  2IGQ A;  3PDN A;  4JDS A;  4YPA A;  4Z4P A;  1N3J A;  5T0M A;  3RIB A;  5F59 A;  5T5G A;  4YNM A;  4QEO A;  3OPE A;  3S8P A;  3M58 A;  3MO5 A;  3OOI A;  1PEG A;  4C1Q A;  5TEG A;  5HI7 A;  4E47 A;  5EX0 A;  5JJ0 A;  5EX3 A;  5T0K A;  1N6A A;  4O6F A;  2W5Y A;  3CBP A;  5JIN A;  3TG5 A;  4YND A;  5TTF A;  3QWP A;  2JV0 A;  4LDG A;  1MUF A;  4J7F A;  3KMA A;  4YPU A;  5HQ8 A;  3S7B A;  4NJ5 A;  1N6C A;  3S7J A;  1ZKK A;  3CBO A;  3KMJ A;  3KMT A;  3BO5 A;  5F6L A;  3M59 A;  4IJD A;  5JIY A;  2W5Z A;  3OXG A;  4QEP A;  5EG2 A;  2QPW A;  3RU0 A;  3M57 A;  3OS5 A;  5F6K C;  4J83 A;  5ARG A;  4H12 A;  2F69 A;  5LSZ A;  3SWC A;  5JHN A;  3SW9 A;  3S7F A;  4JLG A;  3OXL A; 
#chains in the Genus database with same CATH topology
 5TH7 A;  1MT6 A;  3N71 A;  1MVX A;  2RFI A;  3F9Z A;  3M56 A;  3OXF A;  3QWW A;  1MVH A;  2G46 A;  5KJL A;  3M5A A;  3MO2 A;  3MO0 A;  4QEN A;  3DAL A;  5AYF A;  3QWV A;  4I51 A;  5CPR B;  4YNP A;  2O8J A;  3EP0 A;  4WUY A;  4NVQ A;  4AU7 A;  4J7I A;  5KJN A;  3S7D A;  4MI5 A;  1H3I A;  3F9Y A;  1O9S A;  3F9X A;  3M54 A;  4YPE A;  3F9W A;  3TG4 A;  4IJ8 A;  3VV0 A;  3DB5 A;  5KJM A;  3CBM A;  5KJK A;  5F5E A;  4RZ0 A;  3RJW A;  3RAY A;  3FPD A;  2BQZ A;  2R3A A;  5LSX A;  5CCM A;  1ML9 A;  4BUP A;  1XQH A;  3M53 A;  3VUZ A;  3MEK A;  4FMU A;  4MI0 A;  3M55 A;  3K5K A;  5CCL A;  4O30 A;  3HNA A;  3RQ4 A;  3IHX A;  4J8O A;  5ARF A;  2IGQ A;  3PDN A;  4JDS A;  4YPA A;  4Z4P A;  1N3J A;  5T0M A;  3RIB A;  5F59 A;  5T5G A;  4YNM A;  4QEO A;  3OPE A;  3S8P A;  3M58 A;  3MO5 A;  3OOI A;  1PEG A;  4C1Q A;  5TEG A;  5HI7 A;  4E47 A;  5EX0 A;  5JJ0 A;  5EX3 A;  5T0K A;  1N6A A;  4O6F A;  2W5Y A;  3CBP A;  5JIN A;  3TG5 A;  4YND A;  5TTF A;  3QWP A;  2JV0 A;  4LDG A;  1MUF A;  4J7F A;  3KMA A;  4YPU A;  5HQ8 A;  3S7B A;  4NJ5 A;  1N6C A;  3S7J A;  1ZKK A;  3CBO A;  3KMJ A;  3KMT A;  3BO5 A;  5F6L A;  3M59 A;  4IJD A;  5JIY A;  2W5Z A;  3OXG A;  4QEP A;  5EG2 A;  2QPW A;  3RU0 A;  3M57 A;  3OS5 A;  5F6K C;  4J83 A;  5ARG A;  4H12 A;  2F69 A;  5LSZ A;  3SWC A;  5JHN A;  3SW9 A;  3S7F A;  4JLG A;  3OXL A; 
#chains in the Genus database with same CATH homology
 5TH7 A;  1MT6 A;  3N71 A;  1MVX A;  2RFI A;  3F9Z A;  3M56 A;  3OXF A;  3QWW A;  1MVH A;  2G46 A;  5KJL A;  3M5A A;  3MO2 A;  3MO0 A;  4QEN A;  3DAL A;  5AYF A;  3QWV A;  4I51 A;  5CPR B;  4YNP A;  2O8J A;  3EP0 A;  4WUY A;  4NVQ A;  4AU7 A;  4J7I A;  5KJN A;  3S7D A;  4MI5 A;  1H3I A;  3F9Y A;  1O9S A;  3F9X A;  3M54 A;  4YPE A;  3F9W A;  3TG4 A;  4IJ8 A;  3VV0 A;  3DB5 A;  5KJM A;  3CBM A;  5KJK A;  5F5E A;  4RZ0 A;  3RJW A;  3RAY A;  3FPD A;  2BQZ A;  2R3A A;  5LSX A;  5CCM A;  1ML9 A;  4BUP A;  1XQH A;  3M53 A;  3VUZ A;  3MEK A;  4FMU A;  4MI0 A;  3M55 A;  3K5K A;  5CCL A;  4O30 A;  3HNA A;  3RQ4 A;  3IHX A;  4J8O A;  5ARF A;  2IGQ A;  3PDN A;  4JDS A;  4YPA A;  4Z4P A;  1N3J A;  5T0M A;  3RIB A;  5F59 A;  5T5G A;  4YNM A;  4QEO A;  3OPE A;  3S8P A;  3M58 A;  3MO5 A;  3OOI A;  1PEG A;  4C1Q A;  5TEG A;  5HI7 A;  4E47 A;  5EX0 A;  5JJ0 A;  5EX3 A;  5T0K A;  1N6A A;  4O6F A;  2W5Y A;  3CBP A;  5JIN A;  3TG5 A;  4YND A;  5TTF A;  3QWP A;  2JV0 A;  4LDG A;  1MUF A;  4J7F A;  3KMA A;  4YPU A;  5HQ8 A;  3S7B A;  4NJ5 A;  1N6C A;  3S7J A;  1ZKK A;  3CBO A;  3KMJ A;  3KMT A;  3BO5 A;  5F6L A;  3M59 A;  4IJD A;  5JIY A;  2W5Z A;  3OXG A;  4QEP A;  5EG2 A;  2QPW A;  3RU0 A;  3M57 A;  3OS5 A;  5F6K C;  4J83 A;  5ARG A;  4H12 A;  2F69 A;  5LSZ A;  3SWC A;  5JHN A;  3SW9 A;  3S7F A;  4JLG A;  3OXL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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