5T0KA

Structure of g9a set-domain with h3k9m mutant peptide and sam
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
268
structure length
264
Chain Sequence
KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 72
structure length 264
sequence length 268
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0kA00
4I51A 3QWPA 5ARFA 3TG5A 3M55A 3OXFA 1MUFA 4AU7A 2W5ZA 3M53A 2O8JA 3DB5A 3M57A 2F69A 4QEPA 2JV0A 4J7IA 5LSXA 4YPUA 5JINA 5HI7A 3M54A 5CCMA 5CPRB 1H3IA 4NJ5A 2W5YA 5JIYA 3CBPA 1N3JA 3IHXA 3RQ4A 5TH7A 5JHNA 3M59A 5LSZA 3M56A 3QWVA 4IJDA 5KJMA 5F6KC 5TEGA 5EX3A 3MO5A 4J7FA 3CBOA 1N6AA 1O9SA 3RAYA 3RJWA 3KMJA 4FMUA 4O30A 5JJ0A 4YNPA 3S8PA 3SW9A 3SWCA 4J8OA 5KJKA 4E47A 1ML9A 3KMTA 5T0KA 3RU0A 3OXLA 4J83A 5AYFA 3OPEA 3HNAA 4JLGA 3VUZA 3MO0A 3KMAA 2G46A 3S7FA 3CBMA 4QEOA 4BUPA 4JDSA 4YNDA 4Z4PA 3QWWA 3MO2A 5KJLA 5F5EA 1N6CA 3S7BA 5F6LA 5TTFA 3PDNA 4YPAA 2QPWA 3K5KA 4QENA 5T5GA 1MT6A 3EP0A 4LDGA 3BO5A 5CCLA 1MVHA 1MVXA 3MEKA 4YPEA 3OOIA 4C1QA 2IGQA 3FPDA 3F9ZA 4IJ8A 3F9WA 1PEGA 5HQ8A 3DALA 4WUYA 5F59A 4NVQA 4H12A 3S7DA 3OS5A 4O6FA 5KJNA 3M5AA 4YNMA 3TG4A 3RIBA 3OXGA 3VV0A 5T0MA 5ARGA 1XQHA 3F9YA 2R3AA 5EG2A 4MI5A 5EX0A 4RZ0A 3N71A 2BQZA 2RFIA 3F9XA 1ZKKA 4MI0A 3M58A 3S7JA
chains in the Genus database with same CATH superfamily
4I51A 3QWPA 5ARFA 3TG5A 3M55A 3OXFA 1MUFA 4AU7A 2W5ZA 3M53A 2O8JA 3DB5A 3M57A 2F69A 4QEPA 2JV0A 4J7IA 5LSXA 4YPUA 5JINA 5HI7A 3M54A 5CCMA 5CPRB 1H3IA 4NJ5A 2W5YA 5JIYA 3CBPA 1N3JA 3IHXA 3RQ4A 5TH7A 5JHNA 3M59A 5LSZA 3M56A 3QWVA 4IJDA 5KJMA 5F6KC 5TEGA 5EX3A 3MO5A 4J7FA 3CBOA 1N6AA 1O9SA 3RAYA 3RJWA 3KMJA 4FMUA 4O30A 5JJ0A 4YNPA 3S8PA 3SW9A 3SWCA 4J8OA 5KJKA 4E47A 1ML9A 3KMTA 5T0KA 3RU0A 3OXLA 4J83A 5AYFA 3OPEA 3HNAA 4JLGA 3VUZA 3MO0A 3KMAA 2G46A 3S7FA 3CBMA 4QEOA 4BUPA 4JDSA 4YNDA 4Z4PA 3QWWA 3MO2A 5KJLA 5F5EA 1N6CA 3S7BA 5F6LA 5TTFA 3PDNA 4YPAA 2QPWA 3K5KA 4QENA 5T5GA 1MT6A 3EP0A 4LDGA 3BO5A 5CCLA 1MVHA 1MVXA 3MEKA 4YPEA 3OOIA 4C1QA 2IGQA 3FPDA 3F9ZA 4IJ8A 3F9WA 1PEGA 5HQ8A 3DALA 4WUYA 5F59A 4NVQA 4H12A 3S7DA 3OS5A 4O6FA 5KJNA 3M5AA 4YNMA 3TG4A 3RIBA 3OXGA 3VV0A 5T0MA 5ARGA 1XQHA 3F9YA 2R3AA 5EG2A 4MI5A 5EX0A 4RZ0A 3N71A 2BQZA 2RFIA 3F9XA 1ZKKA 4MI0A 3M58A 3S7JA
chains in the Genus database with same CATH topology
4I51A 3QWPA 5ARFA 3TG5A 3M55A 3OXFA 1MUFA 4AU7A 2W5ZA 3M53A 2O8JA 3DB5A 3M57A 2F69A 4QEPA 2JV0A 4J7IA 5LSXA 4YPUA 5JINA 5HI7A 3M54A 5CCMA 5CPRB 1H3IA 4NJ5A 2W5YA 5JIYA 3CBPA 1N3JA 3IHXA 3RQ4A 5TH7A 5JHNA 3M59A 5LSZA 3M56A 3QWVA 4IJDA 5KJMA 5F6KC 5TEGA 5EX3A 3MO5A 4J7FA 3CBOA 1N6AA 1O9SA 3RAYA 3RJWA 3KMJA 4FMUA 4O30A 5JJ0A 4YNPA 3S8PA 3SW9A 3SWCA 4J8OA 5KJKA 4E47A 1ML9A 3KMTA 5T0KA 3RU0A 3OXLA 4J83A 5AYFA 3OPEA 3HNAA 4JLGA 3VUZA 3MO0A 3KMAA 2G46A 3S7FA 3CBMA 4QEOA 4BUPA 4JDSA 4YNDA 4Z4PA 3QWWA 3MO2A 5KJLA 5F5EA 1N6CA 3S7BA 5F6LA 5TTFA 3PDNA 4YPAA 2QPWA 3K5KA 4QENA 5T5GA 1MT6A 3EP0A 4LDGA 3BO5A 5CCLA 1MVHA 1MVXA 3MEKA 4YPEA 3OOIA 4C1QA 2IGQA 3FPDA 3F9ZA 4IJ8A 3F9WA 1PEGA 5HQ8A 3DALA 4WUYA 5F59A 4NVQA 4H12A 3S7DA 3OS5A 4O6FA 5KJNA 3M5AA 4YNMA 3TG4A 3RIBA 3OXGA 3VV0A 5T0MA 5ARGA 1XQHA 3F9YA 2R3AA 5EG2A 4MI5A 5EX0A 4RZ0A 3N71A 2BQZA 2RFIA 3F9XA 1ZKKA 4MI0A 3M58A 3S7JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I51 A;  3QWP A;  5ARF A;  3TG5 A;  3M55 A;  3OXF A;  1MUF A;  4AU7 A;  2W5Z A;  3M53 A;  2O8J A;  3DB5 A;  3M57 A;  2F69 A;  4QEP A;  2JV0 A;  4J7I A;  5LSX A;  4YPU A;  5JIN A;  5HI7 A;  3M54 A;  5CCM A;  5CPR B;  1H3I A;  4NJ5 A;  2W5Y A;  5JIY A;  3CBP A;  1N3J A;  3IHX A;  3RQ4 A;  5TH7 A;  5JHN A;  3M59 A;  5LSZ A;  3M56 A;  3QWV A;  4IJD A;  5KJM A;  5F6K C;  5TEG A;  5EX3 A;  3MO5 A;  4J7F A;  3CBO A;  1N6A A;  1O9S A;  3RAY A;  3RJW A;  3KMJ A;  4FMU A;  4O30 A;  5JJ0 A;  4YNP A;  3S8P A;  3SW9 A;  3SWC A;  4J8O A;  5KJK A;  4E47 A;  1ML9 A;  3KMT A;  5T0K A;  3RU0 A;  3OXL A;  4J83 A;  5AYF A;  3OPE A;  3HNA A;  4JLG A;  3VUZ A;  3MO0 A;  3KMA A;  2G46 A;  3S7F A;  3CBM A;  4QEO A;  4BUP A;  4JDS A;  4YND A;  4Z4P A;  3QWW A;  3MO2 A;  5KJL A;  5F5E A;  1N6C A;  3S7B A;  5F6L A;  5TTF A;  3PDN A;  4YPA A;  2QPW A;  3K5K A;  4QEN A;  5T5G A;  1MT6 A;  3EP0 A;  4LDG A;  3BO5 A;  5CCL A;  1MVH A;  1MVX A;  3MEK A;  4YPE A;  3OOI A;  4C1Q A;  2IGQ A;  3FPD A;  3F9Z A;  4IJ8 A;  3F9W A;  1PEG A;  5HQ8 A;  3DAL A;  4WUY A;  5F59 A;  4NVQ A;  4H12 A;  3S7D A;  3OS5 A;  4O6F A;  5KJN A;  3M5A A;  4YNM A;  3TG4 A;  3RIB A;  3OXG A;  3VV0 A;  5T0M A;  5ARG A;  1XQH A;  3F9Y A;  2R3A A;  5EG2 A;  4MI5 A;  5EX0 A;  4RZ0 A;  3N71 A;  2BQZ A;  2RFI A;  3F9X A;  1ZKK A;  4MI0 A;  3M58 A;  3S7J A; 
#chains in the Genus database with same CATH topology
 4I51 A;  3QWP A;  5ARF A;  3TG5 A;  3M55 A;  3OXF A;  1MUF A;  4AU7 A;  2W5Z A;  3M53 A;  2O8J A;  3DB5 A;  3M57 A;  2F69 A;  4QEP A;  2JV0 A;  4J7I A;  5LSX A;  4YPU A;  5JIN A;  5HI7 A;  3M54 A;  5CCM A;  5CPR B;  1H3I A;  4NJ5 A;  2W5Y A;  5JIY A;  3CBP A;  1N3J A;  3IHX A;  3RQ4 A;  5TH7 A;  5JHN A;  3M59 A;  5LSZ A;  3M56 A;  3QWV A;  4IJD A;  5KJM A;  5F6K C;  5TEG A;  5EX3 A;  3MO5 A;  4J7F A;  3CBO A;  1N6A A;  1O9S A;  3RAY A;  3RJW A;  3KMJ A;  4FMU A;  4O30 A;  5JJ0 A;  4YNP A;  3S8P A;  3SW9 A;  3SWC A;  4J8O A;  5KJK A;  4E47 A;  1ML9 A;  3KMT A;  5T0K A;  3RU0 A;  3OXL A;  4J83 A;  5AYF A;  3OPE A;  3HNA A;  4JLG A;  3VUZ A;  3MO0 A;  3KMA A;  2G46 A;  3S7F A;  3CBM A;  4QEO A;  4BUP A;  4JDS A;  4YND A;  4Z4P A;  3QWW A;  3MO2 A;  5KJL A;  5F5E A;  1N6C A;  3S7B A;  5F6L A;  5TTF A;  3PDN A;  4YPA A;  2QPW A;  3K5K A;  4QEN A;  5T5G A;  1MT6 A;  3EP0 A;  4LDG A;  3BO5 A;  5CCL A;  1MVH A;  1MVX A;  3MEK A;  4YPE A;  3OOI A;  4C1Q A;  2IGQ A;  3FPD A;  3F9Z A;  4IJ8 A;  3F9W A;  1PEG A;  5HQ8 A;  3DAL A;  4WUY A;  5F59 A;  4NVQ A;  4H12 A;  3S7D A;  3OS5 A;  4O6F A;  5KJN A;  3M5A A;  4YNM A;  3TG4 A;  3RIB A;  3OXG A;  3VV0 A;  5T0M A;  5ARG A;  1XQH A;  3F9Y A;  2R3A A;  5EG2 A;  4MI5 A;  5EX0 A;  4RZ0 A;  3N71 A;  2BQZ A;  2RFI A;  3F9X A;  1ZKK A;  4MI0 A;  3M58 A;  3S7J A; 
#chains in the Genus database with same CATH homology
 4I51 A;  3QWP A;  5ARF A;  3TG5 A;  3M55 A;  3OXF A;  1MUF A;  4AU7 A;  2W5Z A;  3M53 A;  2O8J A;  3DB5 A;  3M57 A;  2F69 A;  4QEP A;  2JV0 A;  4J7I A;  5LSX A;  4YPU A;  5JIN A;  5HI7 A;  3M54 A;  5CCM A;  5CPR B;  1H3I A;  4NJ5 A;  2W5Y A;  5JIY A;  3CBP A;  1N3J A;  3IHX A;  3RQ4 A;  5TH7 A;  5JHN A;  3M59 A;  5LSZ A;  3M56 A;  3QWV A;  4IJD A;  5KJM A;  5F6K C;  5TEG A;  5EX3 A;  3MO5 A;  4J7F A;  3CBO A;  1N6A A;  1O9S A;  3RAY A;  3RJW A;  3KMJ A;  4FMU A;  4O30 A;  5JJ0 A;  4YNP A;  3S8P A;  3SW9 A;  3SWC A;  4J8O A;  5KJK A;  4E47 A;  1ML9 A;  3KMT A;  5T0K A;  3RU0 A;  3OXL A;  4J83 A;  5AYF A;  3OPE A;  3HNA A;  4JLG A;  3VUZ A;  3MO0 A;  3KMA A;  2G46 A;  3S7F A;  3CBM A;  4QEO A;  4BUP A;  4JDS A;  4YND A;  4Z4P A;  3QWW A;  3MO2 A;  5KJL A;  5F5E A;  1N6C A;  3S7B A;  5F6L A;  5TTF A;  3PDN A;  4YPA A;  2QPW A;  3K5K A;  4QEN A;  5T5G A;  1MT6 A;  3EP0 A;  4LDG A;  3BO5 A;  5CCL A;  1MVH A;  1MVX A;  3MEK A;  4YPE A;  3OOI A;  4C1Q A;  2IGQ A;  3FPD A;  3F9Z A;  4IJ8 A;  3F9W A;  1PEG A;  5HQ8 A;  3DAL A;  4WUY A;  5F59 A;  4NVQ A;  4H12 A;  3S7D A;  3OS5 A;  4O6F A;  5KJN A;  3M5A A;  4YNM A;  3TG4 A;  3RIB A;  3OXG A;  3VV0 A;  5T0M A;  5ARG A;  1XQH A;  3F9Y A;  2R3A A;  5EG2 A;  4MI5 A;  5EX0 A;  4RZ0 A;  3N71 A;  2BQZ A;  2RFI A;  3F9X A;  1ZKK A;  4MI0 A;  3M58 A;  3S7J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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