5T0KA

Structure of g9a set-domain with h3k9m mutant peptide and sam
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
268
structure length
264
Chain Sequence
KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
total genus 72
structure length 264
sequence length 268
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0kA00
4MI5A 4C1QA 4JDSA 3N71A 5T0KA 3DB5A 3F9WA 4IJ8A 3HNAA 3SW9A 1N6AA 5JHNA 2JV0A 3MO5A 5KJKA 3RIBA 5HQ8A 5KJMA 3F9ZA 3SWCA 3M53A 3M56A 4O30A 3PDNA 3F9YA 5AYFA 2O8JA 3M59A 3S7DA 5TH7A 4RZ0A 4YPEA 3QWWA 3M54A 3DALA 2BQZA 3OPEA 3OXLA 1ML9A 3OXGA 5JIYA 3QWPA 2RFIA 1MT6A 5LSZA 3M58A 3S7BA 3KMJA 4LDGA 1H3IA 3MEKA 4JLGA 4NVQA 3RU0A 4MI0A 5ARFA 5KJLA 1PEGA 3CBMA 4J7IA 1MVXA 5F6LA 3MO0A 5F5EA 1ZKKA 5CPRB 3M57A 4H12A 2W5ZA 1N6CA 4WUYA 5ARGA 4I51A 3IHXA 3RJWA 3OXFA 3MO2A 4Z4PA 2F69A 2IGQA 5KJNA 1MUFA 4YNPA 4YNDA 3OS5A 3S7FA 3RQ4A 2W5YA 4QEOA 5EX3A 2G46A 5T0MA 5TEGA 4BUPA 3KMAA 2QPWA 3S7JA 1N3JA 3OOIA 3S8PA 3CBPA 5EG2A 4O6FA 4NJ5A 4J8OA 3K5KA 3BO5A 1XQHA 5F59A 4YPUA 1O9SA 5JJ0A 4E47A 4QENA 4AU7A 5CCMA 4YNMA 4J83A 5HI7A 3KMTA 5T5GA 3FPDA 5F6KC 5TTFA 5CCLA 4FMUA 3CBOA 5LSXA 3M55A 3TG5A 3VUZA 3TG4A 1MVHA 4YPAA 5EX0A 3EP0A 4J7FA 4IJDA 3QWVA 3VV0A 3F9XA 5JINA 4QEPA 2R3AA 3M5AA 3RAYA
chains in the Genus database with same CATH superfamily
4MI5A 4C1QA 4JDSA 3N71A 5T0KA 3DB5A 3F9WA 4IJ8A 3HNAA 3SW9A 1N6AA 5JHNA 2JV0A 3MO5A 5KJKA 3RIBA 5HQ8A 5KJMA 3F9ZA 3SWCA 3M53A 3M56A 4O30A 3PDNA 3F9YA 5AYFA 2O8JA 3M59A 3S7DA 5TH7A 4RZ0A 4YPEA 3QWWA 3M54A 3DALA 2BQZA 3OPEA 3OXLA 1ML9A 3OXGA 5JIYA 3QWPA 2RFIA 1MT6A 5LSZA 3M58A 3S7BA 3KMJA 4LDGA 1H3IA 3MEKA 4JLGA 4NVQA 3RU0A 4MI0A 5ARFA 5KJLA 1PEGA 3CBMA 4J7IA 1MVXA 5F6LA 3MO0A 5F5EA 1ZKKA 5CPRB 3M57A 4H12A 2W5ZA 1N6CA 4WUYA 5ARGA 4I51A 3IHXA 3RJWA 3OXFA 3MO2A 4Z4PA 2F69A 2IGQA 5KJNA 1MUFA 4YNPA 4YNDA 3OS5A 3S7FA 3RQ4A 2W5YA 4QEOA 5EX3A 2G46A 5T0MA 5TEGA 4BUPA 3KMAA 2QPWA 3S7JA 1N3JA 3OOIA 3S8PA 3CBPA 5EG2A 4O6FA 4NJ5A 4J8OA 3K5KA 3BO5A 1XQHA 5F59A 4YPUA 1O9SA 5JJ0A 4E47A 4QENA 4AU7A 5CCMA 4YNMA 4J83A 5HI7A 3KMTA 5T5GA 3FPDA 5F6KC 5TTFA 5CCLA 4FMUA 3CBOA 5LSXA 3M55A 3TG5A 3VUZA 3TG4A 1MVHA 4YPAA 5EX0A 3EP0A 4J7FA 4IJDA 3QWVA 3VV0A 3F9XA 5JINA 4QEPA 2R3AA 3M5AA 3RAYA
chains in the Genus database with same CATH topology
4MI5A 4C1QA 4JDSA 3N71A 5T0KA 3DB5A 3F9WA 4IJ8A 3HNAA 3SW9A 1N6AA 5JHNA 2JV0A 3MO5A 5KJKA 3RIBA 5HQ8A 5KJMA 3F9ZA 3SWCA 3M53A 3M56A 4O30A 3PDNA 3F9YA 5AYFA 2O8JA 3M59A 3S7DA 5TH7A 4RZ0A 4YPEA 3QWWA 3M54A 3DALA 2BQZA 3OPEA 3OXLA 1ML9A 3OXGA 5JIYA 3QWPA 2RFIA 1MT6A 5LSZA 3M58A 3S7BA 3KMJA 4LDGA 1H3IA 3MEKA 4JLGA 4NVQA 3RU0A 4MI0A 5ARFA 5KJLA 1PEGA 3CBMA 4J7IA 1MVXA 5F6LA 3MO0A 5F5EA 1ZKKA 5CPRB 3M57A 4H12A 2W5ZA 1N6CA 4WUYA 5ARGA 4I51A 3IHXA 3RJWA 3OXFA 3MO2A 4Z4PA 2F69A 2IGQA 5KJNA 1MUFA 4YNPA 4YNDA 3OS5A 3S7FA 3RQ4A 2W5YA 4QEOA 5EX3A 2G46A 5T0MA 5TEGA 4BUPA 3KMAA 2QPWA 3S7JA 1N3JA 3OOIA 3S8PA 3CBPA 5EG2A 4O6FA 4NJ5A 4J8OA 3K5KA 3BO5A 1XQHA 5F59A 4YPUA 1O9SA 5JJ0A 4E47A 4QENA 4AU7A 5CCMA 4YNMA 4J83A 5HI7A 3KMTA 5T5GA 3FPDA 5F6KC 5TTFA 5CCLA 4FMUA 3CBOA 5LSXA 3M55A 3TG5A 3VUZA 3TG4A 1MVHA 4YPAA 5EX0A 3EP0A 4J7FA 4IJDA 3QWVA 3VV0A 3F9XA 5JINA 4QEPA 2R3AA 3M5AA 3RAYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MI5 A;  4C1Q A;  4JDS A;  3N71 A;  5T0K A;  3DB5 A;  3F9W A;  4IJ8 A;  3HNA A;  3SW9 A;  1N6A A;  5JHN A;  2JV0 A;  3MO5 A;  5KJK A;  3RIB A;  5HQ8 A;  5KJM A;  3F9Z A;  3SWC A;  3M53 A;  3M56 A;  4O30 A;  3PDN A;  3F9Y A;  5AYF A;  2O8J A;  3M59 A;  3S7D A;  5TH7 A;  4RZ0 A;  4YPE A;  3QWW A;  3M54 A;  3DAL A;  2BQZ A;  3OPE A;  3OXL A;  1ML9 A;  3OXG A;  5JIY A;  3QWP A;  2RFI A;  1MT6 A;  5LSZ A;  3M58 A;  3S7B A;  3KMJ A;  4LDG A;  1H3I A;  3MEK A;  4JLG A;  4NVQ A;  3RU0 A;  4MI0 A;  5ARF A;  5KJL A;  1PEG A;  3CBM A;  4J7I A;  1MVX A;  5F6L A;  3MO0 A;  5F5E A;  1ZKK A;  5CPR B;  3M57 A;  4H12 A;  2W5Z A;  1N6C A;  4WUY A;  5ARG A;  4I51 A;  3IHX A;  3RJW A;  3OXF A;  3MO2 A;  4Z4P A;  2F69 A;  2IGQ A;  5KJN A;  1MUF A;  4YNP A;  4YND A;  3OS5 A;  3S7F A;  3RQ4 A;  2W5Y A;  4QEO A;  5EX3 A;  2G46 A;  5T0M A;  5TEG A;  4BUP A;  3KMA A;  2QPW A;  3S7J A;  1N3J A;  3OOI A;  3S8P A;  3CBP A;  5EG2 A;  4O6F A;  4NJ5 A;  4J8O A;  3K5K A;  3BO5 A;  1XQH A;  5F59 A;  4YPU A;  1O9S A;  5JJ0 A;  4E47 A;  4QEN A;  4AU7 A;  5CCM A;  4YNM A;  4J83 A;  5HI7 A;  3KMT A;  5T5G A;  3FPD A;  5F6K C;  5TTF A;  5CCL A;  4FMU A;  3CBO A;  5LSX A;  3M55 A;  3TG5 A;  3VUZ A;  3TG4 A;  1MVH A;  4YPA A;  5EX0 A;  3EP0 A;  4J7F A;  4IJD A;  3QWV A;  3VV0 A;  3F9X A;  5JIN A;  4QEP A;  2R3A A;  3M5A A;  3RAY A; 
#chains in the Genus database with same CATH topology
 4MI5 A;  4C1Q A;  4JDS A;  3N71 A;  5T0K A;  3DB5 A;  3F9W A;  4IJ8 A;  3HNA A;  3SW9 A;  1N6A A;  5JHN A;  2JV0 A;  3MO5 A;  5KJK A;  3RIB A;  5HQ8 A;  5KJM A;  3F9Z A;  3SWC A;  3M53 A;  3M56 A;  4O30 A;  3PDN A;  3F9Y A;  5AYF A;  2O8J A;  3M59 A;  3S7D A;  5TH7 A;  4RZ0 A;  4YPE A;  3QWW A;  3M54 A;  3DAL A;  2BQZ A;  3OPE A;  3OXL A;  1ML9 A;  3OXG A;  5JIY A;  3QWP A;  2RFI A;  1MT6 A;  5LSZ A;  3M58 A;  3S7B A;  3KMJ A;  4LDG A;  1H3I A;  3MEK A;  4JLG A;  4NVQ A;  3RU0 A;  4MI0 A;  5ARF A;  5KJL A;  1PEG A;  3CBM A;  4J7I A;  1MVX A;  5F6L A;  3MO0 A;  5F5E A;  1ZKK A;  5CPR B;  3M57 A;  4H12 A;  2W5Z A;  1N6C A;  4WUY A;  5ARG A;  4I51 A;  3IHX A;  3RJW A;  3OXF A;  3MO2 A;  4Z4P A;  2F69 A;  2IGQ A;  5KJN A;  1MUF A;  4YNP A;  4YND A;  3OS5 A;  3S7F A;  3RQ4 A;  2W5Y A;  4QEO A;  5EX3 A;  2G46 A;  5T0M A;  5TEG A;  4BUP A;  3KMA A;  2QPW A;  3S7J A;  1N3J A;  3OOI A;  3S8P A;  3CBP A;  5EG2 A;  4O6F A;  4NJ5 A;  4J8O A;  3K5K A;  3BO5 A;  1XQH A;  5F59 A;  4YPU A;  1O9S A;  5JJ0 A;  4E47 A;  4QEN A;  4AU7 A;  5CCM A;  4YNM A;  4J83 A;  5HI7 A;  3KMT A;  5T5G A;  3FPD A;  5F6K C;  5TTF A;  5CCL A;  4FMU A;  3CBO A;  5LSX A;  3M55 A;  3TG5 A;  3VUZ A;  3TG4 A;  1MVH A;  4YPA A;  5EX0 A;  3EP0 A;  4J7F A;  4IJD A;  3QWV A;  3VV0 A;  3F9X A;  5JIN A;  4QEP A;  2R3A A;  3M5A A;  3RAY A; 
#chains in the Genus database with same CATH homology
 4MI5 A;  4C1Q A;  4JDS A;  3N71 A;  5T0K A;  3DB5 A;  3F9W A;  4IJ8 A;  3HNA A;  3SW9 A;  1N6A A;  5JHN A;  2JV0 A;  3MO5 A;  5KJK A;  3RIB A;  5HQ8 A;  5KJM A;  3F9Z A;  3SWC A;  3M53 A;  3M56 A;  4O30 A;  3PDN A;  3F9Y A;  5AYF A;  2O8J A;  3M59 A;  3S7D A;  5TH7 A;  4RZ0 A;  4YPE A;  3QWW A;  3M54 A;  3DAL A;  2BQZ A;  3OPE A;  3OXL A;  1ML9 A;  3OXG A;  5JIY A;  3QWP A;  2RFI A;  1MT6 A;  5LSZ A;  3M58 A;  3S7B A;  3KMJ A;  4LDG A;  1H3I A;  3MEK A;  4JLG A;  4NVQ A;  3RU0 A;  4MI0 A;  5ARF A;  5KJL A;  1PEG A;  3CBM A;  4J7I A;  1MVX A;  5F6L A;  3MO0 A;  5F5E A;  1ZKK A;  5CPR B;  3M57 A;  4H12 A;  2W5Z A;  1N6C A;  4WUY A;  5ARG A;  4I51 A;  3IHX A;  3RJW A;  3OXF A;  3MO2 A;  4Z4P A;  2F69 A;  2IGQ A;  5KJN A;  1MUF A;  4YNP A;  4YND A;  3OS5 A;  3S7F A;  3RQ4 A;  2W5Y A;  4QEO A;  5EX3 A;  2G46 A;  5T0M A;  5TEG A;  4BUP A;  3KMA A;  2QPW A;  3S7J A;  1N3J A;  3OOI A;  3S8P A;  3CBP A;  5EG2 A;  4O6F A;  4NJ5 A;  4J8O A;  3K5K A;  3BO5 A;  1XQH A;  5F59 A;  4YPU A;  1O9S A;  5JJ0 A;  4E47 A;  4QEN A;  4AU7 A;  5CCM A;  4YNM A;  4J83 A;  5HI7 A;  3KMT A;  5T5G A;  3FPD A;  5F6K C;  5TTF A;  5CCL A;  4FMU A;  3CBO A;  5LSX A;  3M55 A;  3TG5 A;  3VUZ A;  3TG4 A;  1MVH A;  4YPA A;  5EX0 A;  3EP0 A;  4J7F A;  4IJD A;  3QWV A;  3VV0 A;  3F9X A;  5JIN A;  4QEP A;  2R3A A;  3M5A A;  3RAY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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