5T0KA

Structure of g9a set-domain with h3k9m mutant peptide and sam
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
268
structure length
264
Chain Sequence
KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 72
structure length 264
sequence length 268
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0kA00
4JLGA 3KMAA 4YPAA 2RFIA 3F9WA 3M58A 3M57A 4Z4PA 3S7BA 4NJ5A 4J7IA 1H3IA 4FMUA 4E47A 5LSZA 3BO5A 5F59A 4YNPA 3FPDA 4J8OA 4I51A 1N6AA 3RQ4A 1O9SA 2W5YA 3SWCA 5HQ8A 1N3JA 3M5AA 4YNMA 2G46A 4MI5A 1PEGA 5F5EA 5AYFA 3IHXA 5JHNA 3RIBA 5KJMA 5TH7A 4O30A 3RJWA 5F6KC 3M59A 1ZKKA 4JDSA 5JINA 5ARFA 1ML9A 3RAYA 3DB5A 1MVHA 5JIYA 3K5KA 1MVXA 5EX0A 5KJNA 5CCLA 2W5ZA 4BUPA 3N71A 5T0MA 3MO5A 3DALA 3F9ZA 4NVQA 2R3AA 5TTFA 3QWWA 5EX3A 3CBMA 1MT6A 3F9YA 3OXLA 3RU0A 3S7JA 2JV0A 5ARGA 3TG5A 3TG4A 5JJ0A 3KMJA 4IJ8A 2QPWA 3HNAA 4O6FA 3OOIA 4YNDA 5HI7A 1N6CA 3MEKA 5F6LA 3F9XA 4QEPA 3OXFA 3S8PA 5CPRB 4QENA 3OS5A 2BQZA 2IGQA 4J7FA 5LSXA 1XQHA 4MI0A 4C1QA 3CBOA 3QWVA 4YPEA 5EG2A 2F69A 3S7FA 4AU7A 3VV0A 4WUYA 5KJKA 4QEOA 5T0KA 3M53A 4YPUA 3PDNA 3OXGA 3SW9A 4LDGA 3M55A 3OPEA 3S7DA 4IJDA 3MO2A 5KJLA 3MO0A 4J83A 5T5GA 5TEGA 2O8JA 3M54A 3QWPA 3EP0A 3M56A 3KMTA 4H12A 1MUFA 5CCMA 4RZ0A 3VUZA 3CBPA
chains in the Genus database with same CATH superfamily
4JLGA 3KMAA 4YPAA 2RFIA 3F9WA 3M58A 3M57A 4Z4PA 3S7BA 4NJ5A 4J7IA 1H3IA 4FMUA 4E47A 5LSZA 3BO5A 5F59A 4YNPA 3FPDA 4J8OA 4I51A 1N6AA 3RQ4A 1O9SA 2W5YA 3SWCA 5HQ8A 1N3JA 3M5AA 4YNMA 2G46A 4MI5A 1PEGA 5F5EA 5AYFA 3IHXA 5JHNA 3RIBA 5KJMA 5TH7A 4O30A 3RJWA 5F6KC 3M59A 1ZKKA 4JDSA 5JINA 5ARFA 1ML9A 3RAYA 3DB5A 1MVHA 5JIYA 3K5KA 1MVXA 5EX0A 5KJNA 5CCLA 2W5ZA 4BUPA 3N71A 5T0MA 3MO5A 3DALA 3F9ZA 4NVQA 2R3AA 5TTFA 3QWWA 5EX3A 3CBMA 1MT6A 3F9YA 3OXLA 3RU0A 3S7JA 2JV0A 5ARGA 3TG5A 3TG4A 5JJ0A 3KMJA 4IJ8A 2QPWA 3HNAA 4O6FA 3OOIA 4YNDA 5HI7A 1N6CA 3MEKA 5F6LA 3F9XA 4QEPA 3OXFA 3S8PA 5CPRB 4QENA 3OS5A 2BQZA 2IGQA 4J7FA 5LSXA 1XQHA 4MI0A 4C1QA 3CBOA 3QWVA 4YPEA 5EG2A 2F69A 3S7FA 4AU7A 3VV0A 4WUYA 5KJKA 4QEOA 5T0KA 3M53A 4YPUA 3PDNA 3OXGA 3SW9A 4LDGA 3M55A 3OPEA 3S7DA 4IJDA 3MO2A 5KJLA 3MO0A 4J83A 5T5GA 5TEGA 2O8JA 3M54A 3QWPA 3EP0A 3M56A 3KMTA 4H12A 1MUFA 5CCMA 4RZ0A 3VUZA 3CBPA
chains in the Genus database with same CATH topology
4JLGA 3KMAA 4YPAA 2RFIA 3F9WA 3M58A 3M57A 4Z4PA 3S7BA 4NJ5A 4J7IA 1H3IA 4FMUA 4E47A 5LSZA 3BO5A 5F59A 4YNPA 3FPDA 4J8OA 4I51A 1N6AA 3RQ4A 1O9SA 2W5YA 3SWCA 5HQ8A 1N3JA 3M5AA 4YNMA 2G46A 4MI5A 1PEGA 5F5EA 5AYFA 3IHXA 5JHNA 3RIBA 5KJMA 5TH7A 4O30A 3RJWA 5F6KC 3M59A 1ZKKA 4JDSA 5JINA 5ARFA 1ML9A 3RAYA 3DB5A 1MVHA 5JIYA 3K5KA 1MVXA 5EX0A 5KJNA 5CCLA 2W5ZA 4BUPA 3N71A 5T0MA 3MO5A 3DALA 3F9ZA 4NVQA 2R3AA 5TTFA 3QWWA 5EX3A 3CBMA 1MT6A 3F9YA 3OXLA 3RU0A 3S7JA 2JV0A 5ARGA 3TG5A 3TG4A 5JJ0A 3KMJA 4IJ8A 2QPWA 3HNAA 4O6FA 3OOIA 4YNDA 5HI7A 1N6CA 3MEKA 5F6LA 3F9XA 4QEPA 3OXFA 3S8PA 5CPRB 4QENA 3OS5A 2BQZA 2IGQA 4J7FA 5LSXA 1XQHA 4MI0A 4C1QA 3CBOA 3QWVA 4YPEA 5EG2A 2F69A 3S7FA 4AU7A 3VV0A 4WUYA 5KJKA 4QEOA 5T0KA 3M53A 4YPUA 3PDNA 3OXGA 3SW9A 4LDGA 3M55A 3OPEA 3S7DA 4IJDA 3MO2A 5KJLA 3MO0A 4J83A 5T5GA 5TEGA 2O8JA 3M54A 3QWPA 3EP0A 3M56A 3KMTA 4H12A 1MUFA 5CCMA 4RZ0A 3VUZA 3CBPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JLG A;  3KMA A;  4YPA A;  2RFI A;  3F9W A;  3M58 A;  3M57 A;  4Z4P A;  3S7B A;  4NJ5 A;  4J7I A;  1H3I A;  4FMU A;  4E47 A;  5LSZ A;  3BO5 A;  5F59 A;  4YNP A;  3FPD A;  4J8O A;  4I51 A;  1N6A A;  3RQ4 A;  1O9S A;  2W5Y A;  3SWC A;  5HQ8 A;  1N3J A;  3M5A A;  4YNM A;  2G46 A;  4MI5 A;  1PEG A;  5F5E A;  5AYF A;  3IHX A;  5JHN A;  3RIB A;  5KJM A;  5TH7 A;  4O30 A;  3RJW A;  5F6K C;  3M59 A;  1ZKK A;  4JDS A;  5JIN A;  5ARF A;  1ML9 A;  3RAY A;  3DB5 A;  1MVH A;  5JIY A;  3K5K A;  1MVX A;  5EX0 A;  5KJN A;  5CCL A;  2W5Z A;  4BUP A;  3N71 A;  5T0M A;  3MO5 A;  3DAL A;  3F9Z A;  4NVQ A;  2R3A A;  5TTF A;  3QWW A;  5EX3 A;  3CBM A;  1MT6 A;  3F9Y A;  3OXL A;  3RU0 A;  3S7J A;  2JV0 A;  5ARG A;  3TG5 A;  3TG4 A;  5JJ0 A;  3KMJ A;  4IJ8 A;  2QPW A;  3HNA A;  4O6F A;  3OOI A;  4YND A;  5HI7 A;  1N6C A;  3MEK A;  5F6L A;  3F9X A;  4QEP A;  3OXF A;  3S8P A;  5CPR B;  4QEN A;  3OS5 A;  2BQZ A;  2IGQ A;  4J7F A;  5LSX A;  1XQH A;  4MI0 A;  4C1Q A;  3CBO A;  3QWV A;  4YPE A;  5EG2 A;  2F69 A;  3S7F A;  4AU7 A;  3VV0 A;  4WUY A;  5KJK A;  4QEO A;  5T0K A;  3M53 A;  4YPU A;  3PDN A;  3OXG A;  3SW9 A;  4LDG A;  3M55 A;  3OPE A;  3S7D A;  4IJD A;  3MO2 A;  5KJL A;  3MO0 A;  4J83 A;  5T5G A;  5TEG A;  2O8J A;  3M54 A;  3QWP A;  3EP0 A;  3M56 A;  3KMT A;  4H12 A;  1MUF A;  5CCM A;  4RZ0 A;  3VUZ A;  3CBP A; 
#chains in the Genus database with same CATH topology
 4JLG A;  3KMA A;  4YPA A;  2RFI A;  3F9W A;  3M58 A;  3M57 A;  4Z4P A;  3S7B A;  4NJ5 A;  4J7I A;  1H3I A;  4FMU A;  4E47 A;  5LSZ A;  3BO5 A;  5F59 A;  4YNP A;  3FPD A;  4J8O A;  4I51 A;  1N6A A;  3RQ4 A;  1O9S A;  2W5Y A;  3SWC A;  5HQ8 A;  1N3J A;  3M5A A;  4YNM A;  2G46 A;  4MI5 A;  1PEG A;  5F5E A;  5AYF A;  3IHX A;  5JHN A;  3RIB A;  5KJM A;  5TH7 A;  4O30 A;  3RJW A;  5F6K C;  3M59 A;  1ZKK A;  4JDS A;  5JIN A;  5ARF A;  1ML9 A;  3RAY A;  3DB5 A;  1MVH A;  5JIY A;  3K5K A;  1MVX A;  5EX0 A;  5KJN A;  5CCL A;  2W5Z A;  4BUP A;  3N71 A;  5T0M A;  3MO5 A;  3DAL A;  3F9Z A;  4NVQ A;  2R3A A;  5TTF A;  3QWW A;  5EX3 A;  3CBM A;  1MT6 A;  3F9Y A;  3OXL A;  3RU0 A;  3S7J A;  2JV0 A;  5ARG A;  3TG5 A;  3TG4 A;  5JJ0 A;  3KMJ A;  4IJ8 A;  2QPW A;  3HNA A;  4O6F A;  3OOI A;  4YND A;  5HI7 A;  1N6C A;  3MEK A;  5F6L A;  3F9X A;  4QEP A;  3OXF A;  3S8P A;  5CPR B;  4QEN A;  3OS5 A;  2BQZ A;  2IGQ A;  4J7F A;  5LSX A;  1XQH A;  4MI0 A;  4C1Q A;  3CBO A;  3QWV A;  4YPE A;  5EG2 A;  2F69 A;  3S7F A;  4AU7 A;  3VV0 A;  4WUY A;  5KJK A;  4QEO A;  5T0K A;  3M53 A;  4YPU A;  3PDN A;  3OXG A;  3SW9 A;  4LDG A;  3M55 A;  3OPE A;  3S7D A;  4IJD A;  3MO2 A;  5KJL A;  3MO0 A;  4J83 A;  5T5G A;  5TEG A;  2O8J A;  3M54 A;  3QWP A;  3EP0 A;  3M56 A;  3KMT A;  4H12 A;  1MUF A;  5CCM A;  4RZ0 A;  3VUZ A;  3CBP A; 
#chains in the Genus database with same CATH homology
 4JLG A;  3KMA A;  4YPA A;  2RFI A;  3F9W A;  3M58 A;  3M57 A;  4Z4P A;  3S7B A;  4NJ5 A;  4J7I A;  1H3I A;  4FMU A;  4E47 A;  5LSZ A;  3BO5 A;  5F59 A;  4YNP A;  3FPD A;  4J8O A;  4I51 A;  1N6A A;  3RQ4 A;  1O9S A;  2W5Y A;  3SWC A;  5HQ8 A;  1N3J A;  3M5A A;  4YNM A;  2G46 A;  4MI5 A;  1PEG A;  5F5E A;  5AYF A;  3IHX A;  5JHN A;  3RIB A;  5KJM A;  5TH7 A;  4O30 A;  3RJW A;  5F6K C;  3M59 A;  1ZKK A;  4JDS A;  5JIN A;  5ARF A;  1ML9 A;  3RAY A;  3DB5 A;  1MVH A;  5JIY A;  3K5K A;  1MVX A;  5EX0 A;  5KJN A;  5CCL A;  2W5Z A;  4BUP A;  3N71 A;  5T0M A;  3MO5 A;  3DAL A;  3F9Z A;  4NVQ A;  2R3A A;  5TTF A;  3QWW A;  5EX3 A;  3CBM A;  1MT6 A;  3F9Y A;  3OXL A;  3RU0 A;  3S7J A;  2JV0 A;  5ARG A;  3TG5 A;  3TG4 A;  5JJ0 A;  3KMJ A;  4IJ8 A;  2QPW A;  3HNA A;  4O6F A;  3OOI A;  4YND A;  5HI7 A;  1N6C A;  3MEK A;  5F6L A;  3F9X A;  4QEP A;  3OXF A;  3S8P A;  5CPR B;  4QEN A;  3OS5 A;  2BQZ A;  2IGQ A;  4J7F A;  5LSX A;  1XQH A;  4MI0 A;  4C1Q A;  3CBO A;  3QWV A;  4YPE A;  5EG2 A;  2F69 A;  3S7F A;  4AU7 A;  3VV0 A;  4WUY A;  5KJK A;  4QEO A;  5T0K A;  3M53 A;  4YPU A;  3PDN A;  3OXG A;  3SW9 A;  4LDG A;  3M55 A;  3OPE A;  3S7D A;  4IJD A;  3MO2 A;  5KJL A;  3MO0 A;  4J83 A;  5T5G A;  5TEG A;  2O8J A;  3M54 A;  3QWP A;  3EP0 A;  3M56 A;  3KMT A;  4H12 A;  1MUF A;  5CCM A;  4RZ0 A;  3VUZ A;  3CBP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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