5T0MA

A histone h3k9m mutation traps histone methyltransferase clr4 to prevent heterochromatin spreading
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
264
structure length
260
Chain Sequence
IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 70
structure length 260
sequence length 264
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0mA00
3QWWA 4J8OA 4MI0A 3DB5A 3RAYA 3KMTA 3OS5A 3CBMA 4MI5A 1MUFA 3MO0A 5JHNA 5HQ8A 4FMUA 1MVHA 3MO5A 5CCLA 3M58A 4J83A 3HNAA 2BQZA 5KJMA 2IGQA 3SW9A 5F6LA 5TTFA 3VV0A 5F6KC 5KJNA 3TG5A 2W5ZA 1N6CA 2O8JA 4O6FA 3S8PA 1N6AA 5T0MA 3F9WA 5F59A 5ARFA 3M59A 5T0KA 4QEOA 4IJDA 3F9ZA 1O9SA 5EX3A 5KJLA 3M57A 4NJ5A 5LSXA 2F69A 3KMJA 4J7IA 4BUPA 3M55A 3OXGA 3M53A 5JINA 3RU0A 3DALA 3S7FA 2W5YA 4NVQA 4IJ8A 4LDGA 5AYFA 3OPEA 4E47A 5EG2A 3M5AA 3S7JA 1MT6A 3M54A 3IHXA 1N3JA 3K5KA 4RZ0A 4C1QA 3OXLA 5EX0A 5KJKA 3CBPA 5T5GA 4JDSA 3TG4A 3FPDA 3RQ4A 4YPUA 5TH7A 4AU7A 5TEGA 5CPRB 4O30A 3OXFA 4JLGA 3PDNA 4J7FA 1ML9A 1PEGA 4YPAA 4YNDA 4YNPA 3MEKA 3S7DA 4YNMA 5CCMA 2G46A 5JIYA 2R3AA 3F9YA 5HI7A 3RIBA 3VUZA 3SWCA 3KMAA 3QWPA 3M56A 5ARGA 3QWVA 4YPEA 3EP0A 3CBOA 1ZKKA 2QPWA 3OOIA 2JV0A 4H12A 4WUYA 4QEPA 1XQHA 4Z4PA 3RJWA 5JJ0A 3S7BA 5LSZA 3BO5A 1MVXA 1H3IA 4I51A 3MO2A 3F9XA 4QENA 3N71A 2RFIA 5F5EA
chains in the Genus database with same CATH superfamily
3QWWA 4J8OA 4MI0A 3DB5A 3RAYA 3KMTA 3OS5A 3CBMA 4MI5A 1MUFA 3MO0A 5JHNA 5HQ8A 4FMUA 1MVHA 3MO5A 5CCLA 3M58A 4J83A 3HNAA 2BQZA 5KJMA 2IGQA 3SW9A 5F6LA 5TTFA 3VV0A 5F6KC 5KJNA 3TG5A 2W5ZA 1N6CA 2O8JA 4O6FA 3S8PA 1N6AA 5T0MA 3F9WA 5F59A 5ARFA 3M59A 5T0KA 4QEOA 4IJDA 3F9ZA 1O9SA 5EX3A 5KJLA 3M57A 4NJ5A 5LSXA 2F69A 3KMJA 4J7IA 4BUPA 3M55A 3OXGA 3M53A 5JINA 3RU0A 3DALA 3S7FA 2W5YA 4NVQA 4IJ8A 4LDGA 5AYFA 3OPEA 4E47A 5EG2A 3M5AA 3S7JA 1MT6A 3M54A 3IHXA 1N3JA 3K5KA 4RZ0A 4C1QA 3OXLA 5EX0A 5KJKA 3CBPA 5T5GA 4JDSA 3TG4A 3FPDA 3RQ4A 4YPUA 5TH7A 4AU7A 5TEGA 5CPRB 4O30A 3OXFA 4JLGA 3PDNA 4J7FA 1ML9A 1PEGA 4YPAA 4YNDA 4YNPA 3MEKA 3S7DA 4YNMA 5CCMA 2G46A 5JIYA 2R3AA 3F9YA 5HI7A 3RIBA 3VUZA 3SWCA 3KMAA 3QWPA 3M56A 5ARGA 3QWVA 4YPEA 3EP0A 3CBOA 1ZKKA 2QPWA 3OOIA 2JV0A 4H12A 4WUYA 4QEPA 1XQHA 4Z4PA 3RJWA 5JJ0A 3S7BA 5LSZA 3BO5A 1MVXA 1H3IA 4I51A 3MO2A 3F9XA 4QENA 3N71A 2RFIA 5F5EA
chains in the Genus database with same CATH topology
3QWWA 4J8OA 4MI0A 3DB5A 3RAYA 3KMTA 3OS5A 3CBMA 4MI5A 1MUFA 3MO0A 5JHNA 5HQ8A 4FMUA 1MVHA 3MO5A 5CCLA 3M58A 4J83A 3HNAA 2BQZA 5KJMA 2IGQA 3SW9A 5F6LA 5TTFA 3VV0A 5F6KC 5KJNA 3TG5A 2W5ZA 1N6CA 2O8JA 4O6FA 3S8PA 1N6AA 5T0MA 3F9WA 5F59A 5ARFA 3M59A 5T0KA 4QEOA 4IJDA 3F9ZA 1O9SA 5EX3A 5KJLA 3M57A 4NJ5A 5LSXA 2F69A 3KMJA 4J7IA 4BUPA 3M55A 3OXGA 3M53A 5JINA 3RU0A 3DALA 3S7FA 2W5YA 4NVQA 4IJ8A 4LDGA 5AYFA 3OPEA 4E47A 5EG2A 3M5AA 3S7JA 1MT6A 3M54A 3IHXA 1N3JA 3K5KA 4RZ0A 4C1QA 3OXLA 5EX0A 5KJKA 3CBPA 5T5GA 4JDSA 3TG4A 3FPDA 3RQ4A 4YPUA 5TH7A 4AU7A 5TEGA 5CPRB 4O30A 3OXFA 4JLGA 3PDNA 4J7FA 1ML9A 1PEGA 4YPAA 4YNDA 4YNPA 3MEKA 3S7DA 4YNMA 5CCMA 2G46A 5JIYA 2R3AA 3F9YA 5HI7A 3RIBA 3VUZA 3SWCA 3KMAA 3QWPA 3M56A 5ARGA 3QWVA 4YPEA 3EP0A 3CBOA 1ZKKA 2QPWA 3OOIA 2JV0A 4H12A 4WUYA 4QEPA 1XQHA 4Z4PA 3RJWA 5JJ0A 3S7BA 5LSZA 3BO5A 1MVXA 1H3IA 4I51A 3MO2A 3F9XA 4QENA 3N71A 2RFIA 5F5EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QWW A;  4J8O A;  4MI0 A;  3DB5 A;  3RAY A;  3KMT A;  3OS5 A;  3CBM A;  4MI5 A;  1MUF A;  3MO0 A;  5JHN A;  5HQ8 A;  4FMU A;  1MVH A;  3MO5 A;  5CCL A;  3M58 A;  4J83 A;  3HNA A;  2BQZ A;  5KJM A;  2IGQ A;  3SW9 A;  5F6L A;  5TTF A;  3VV0 A;  5F6K C;  5KJN A;  3TG5 A;  2W5Z A;  1N6C A;  2O8J A;  4O6F A;  3S8P A;  1N6A A;  5T0M A;  3F9W A;  5F59 A;  5ARF A;  3M59 A;  5T0K A;  4QEO A;  4IJD A;  3F9Z A;  1O9S A;  5EX3 A;  5KJL A;  3M57 A;  4NJ5 A;  5LSX A;  2F69 A;  3KMJ A;  4J7I A;  4BUP A;  3M55 A;  3OXG A;  3M53 A;  5JIN A;  3RU0 A;  3DAL A;  3S7F A;  2W5Y A;  4NVQ A;  4IJ8 A;  4LDG A;  5AYF A;  3OPE A;  4E47 A;  5EG2 A;  3M5A A;  3S7J A;  1MT6 A;  3M54 A;  3IHX A;  1N3J A;  3K5K A;  4RZ0 A;  4C1Q A;  3OXL A;  5EX0 A;  5KJK A;  3CBP A;  5T5G A;  4JDS A;  3TG4 A;  3FPD A;  3RQ4 A;  4YPU A;  5TH7 A;  4AU7 A;  5TEG A;  5CPR B;  4O30 A;  3OXF A;  4JLG A;  3PDN A;  4J7F A;  1ML9 A;  1PEG A;  4YPA A;  4YND A;  4YNP A;  3MEK A;  3S7D A;  4YNM A;  5CCM A;  2G46 A;  5JIY A;  2R3A A;  3F9Y A;  5HI7 A;  3RIB A;  3VUZ A;  3SWC A;  3KMA A;  3QWP A;  3M56 A;  5ARG A;  3QWV A;  4YPE A;  3EP0 A;  3CBO A;  1ZKK A;  2QPW A;  3OOI A;  2JV0 A;  4H12 A;  4WUY A;  4QEP A;  1XQH A;  4Z4P A;  3RJW A;  5JJ0 A;  3S7B A;  5LSZ A;  3BO5 A;  1MVX A;  1H3I A;  4I51 A;  3MO2 A;  3F9X A;  4QEN A;  3N71 A;  2RFI A;  5F5E A; 
#chains in the Genus database with same CATH topology
 3QWW A;  4J8O A;  4MI0 A;  3DB5 A;  3RAY A;  3KMT A;  3OS5 A;  3CBM A;  4MI5 A;  1MUF A;  3MO0 A;  5JHN A;  5HQ8 A;  4FMU A;  1MVH A;  3MO5 A;  5CCL A;  3M58 A;  4J83 A;  3HNA A;  2BQZ A;  5KJM A;  2IGQ A;  3SW9 A;  5F6L A;  5TTF A;  3VV0 A;  5F6K C;  5KJN A;  3TG5 A;  2W5Z A;  1N6C A;  2O8J A;  4O6F A;  3S8P A;  1N6A A;  5T0M A;  3F9W A;  5F59 A;  5ARF A;  3M59 A;  5T0K A;  4QEO A;  4IJD A;  3F9Z A;  1O9S A;  5EX3 A;  5KJL A;  3M57 A;  4NJ5 A;  5LSX A;  2F69 A;  3KMJ A;  4J7I A;  4BUP A;  3M55 A;  3OXG A;  3M53 A;  5JIN A;  3RU0 A;  3DAL A;  3S7F A;  2W5Y A;  4NVQ A;  4IJ8 A;  4LDG A;  5AYF A;  3OPE A;  4E47 A;  5EG2 A;  3M5A A;  3S7J A;  1MT6 A;  3M54 A;  3IHX A;  1N3J A;  3K5K A;  4RZ0 A;  4C1Q A;  3OXL A;  5EX0 A;  5KJK A;  3CBP A;  5T5G A;  4JDS A;  3TG4 A;  3FPD A;  3RQ4 A;  4YPU A;  5TH7 A;  4AU7 A;  5TEG A;  5CPR B;  4O30 A;  3OXF A;  4JLG A;  3PDN A;  4J7F A;  1ML9 A;  1PEG A;  4YPA A;  4YND A;  4YNP A;  3MEK A;  3S7D A;  4YNM A;  5CCM A;  2G46 A;  5JIY A;  2R3A A;  3F9Y A;  5HI7 A;  3RIB A;  3VUZ A;  3SWC A;  3KMA A;  3QWP A;  3M56 A;  5ARG A;  3QWV A;  4YPE A;  3EP0 A;  3CBO A;  1ZKK A;  2QPW A;  3OOI A;  2JV0 A;  4H12 A;  4WUY A;  4QEP A;  1XQH A;  4Z4P A;  3RJW A;  5JJ0 A;  3S7B A;  5LSZ A;  3BO5 A;  1MVX A;  1H3I A;  4I51 A;  3MO2 A;  3F9X A;  4QEN A;  3N71 A;  2RFI A;  5F5E A; 
#chains in the Genus database with same CATH homology
 3QWW A;  4J8O A;  4MI0 A;  3DB5 A;  3RAY A;  3KMT A;  3OS5 A;  3CBM A;  4MI5 A;  1MUF A;  3MO0 A;  5JHN A;  5HQ8 A;  4FMU A;  1MVH A;  3MO5 A;  5CCL A;  3M58 A;  4J83 A;  3HNA A;  2BQZ A;  5KJM A;  2IGQ A;  3SW9 A;  5F6L A;  5TTF A;  3VV0 A;  5F6K C;  5KJN A;  3TG5 A;  2W5Z A;  1N6C A;  2O8J A;  4O6F A;  3S8P A;  1N6A A;  5T0M A;  3F9W A;  5F59 A;  5ARF A;  3M59 A;  5T0K A;  4QEO A;  4IJD A;  3F9Z A;  1O9S A;  5EX3 A;  5KJL A;  3M57 A;  4NJ5 A;  5LSX A;  2F69 A;  3KMJ A;  4J7I A;  4BUP A;  3M55 A;  3OXG A;  3M53 A;  5JIN A;  3RU0 A;  3DAL A;  3S7F A;  2W5Y A;  4NVQ A;  4IJ8 A;  4LDG A;  5AYF A;  3OPE A;  4E47 A;  5EG2 A;  3M5A A;  3S7J A;  1MT6 A;  3M54 A;  3IHX A;  1N3J A;  3K5K A;  4RZ0 A;  4C1Q A;  3OXL A;  5EX0 A;  5KJK A;  3CBP A;  5T5G A;  4JDS A;  3TG4 A;  3FPD A;  3RQ4 A;  4YPU A;  5TH7 A;  4AU7 A;  5TEG A;  5CPR B;  4O30 A;  3OXF A;  4JLG A;  3PDN A;  4J7F A;  1ML9 A;  1PEG A;  4YPA A;  4YND A;  4YNP A;  3MEK A;  3S7D A;  4YNM A;  5CCM A;  2G46 A;  5JIY A;  2R3A A;  3F9Y A;  5HI7 A;  3RIB A;  3VUZ A;  3SWC A;  3KMA A;  3QWP A;  3M56 A;  5ARG A;  3QWV A;  4YPE A;  3EP0 A;  3CBO A;  1ZKK A;  2QPW A;  3OOI A;  2JV0 A;  4H12 A;  4WUY A;  4QEP A;  1XQH A;  4Z4P A;  3RJW A;  5JJ0 A;  3S7B A;  5LSZ A;  3BO5 A;  1MVX A;  1H3I A;  4I51 A;  3MO2 A;  3F9X A;  4QEN A;  3N71 A;  2RFI A;  5F5E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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