5T0MA

A histone h3k9m mutation traps histone methyltransferase clr4 to prevent heterochromatin spreading
Total Genus 70
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
264
structure length
260
Chain Sequence
b'IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIAL'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
molecule tags Transferase
source organism Homo sapiens
publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
total genus 70
structure length 260
sequence length 264
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0mA00
4MI0A 3OXGA 4J83A 4J7FA 3MEKA 2IGQA 3KMAA 4NVQA 3VUZA 3QWPA 3K5KA 3KMJA 5KJLA 5JHNA 3MO2A 2O8JA 1N6AA 3M57A 4I51A 4QEOA 3VV0A 5JINA 4QEPA 3DALA 3OOIA 3N71A 1MT6A 1XQHA 5T0KA 3RAYA 3CBPA 3M54A 1MVXA 1O9SA 3S7BA 4YNPA 3RQ4A 3MO5A 3CBOA 3RU0A 5JIYA 3F9WA 1MVHA 3OXFA 3M58A 4WUYA 4YPAA 5F6KC 4RZ0A 4LDGA 5ARGA 5EX3A 1ML9A 4YNMA 4NJ5A 4O30A 5JJ0A 3SWCA 2G46A 3M56A 5ARFA 3KMTA 5EG2A 3S8PA 1PEGA 3M53A 4C1QA 5AYFA 3M59A 3RIBA 4J7IA 4YPUA 4YNDA 5EX0A 3FPDA 4FMUA 5TH7A 3HNAA 5KJNA 4H12A 5F6LA 4IJDA 1ZKKA 5F5EA 3S7FA 4BUPA 3S7JA 1H3IA 3M55A 3RJWA 3MO0A 3F9YA 2QPWA 5TEGA 3DB5A 4MI5A 3QWVA 3IHXA 4JDSA 3PDNA 3TG4A 3QWWA 5LSXA 2JV0A 2F69A 3S7DA 5TTFA 3OPEA 5KJMA 3F9ZA 3OXLA 3OS5A 1MUFA 1N3JA 5CCMA 5T0MA 4QENA 5CCLA 5CPRB 3SW9A 4IJ8A 2BQZA 4AU7A 3CBMA 3TG5A 5T5GA 3M5AA 5F59A 4Z4PA 2RFIA 4J8OA 3F9XA 1N6CA 2R3AA 3BO5A 4E47A 2W5YA 5HQ8A 5HI7A 4YPEA 5KJKA 5LSZA 2W5ZA 4JLGA 3EP0A 4O6FA
chains in the Genus database with same CATH superfamily
4MI0A 3OXGA 4J83A 4J7FA 3MEKA 2IGQA 3KMAA 4NVQA 3VUZA 3QWPA 3K5KA 3KMJA 5KJLA 5JHNA 3MO2A 2O8JA 1N6AA 3M57A 4I51A 4QEOA 3VV0A 5JINA 4QEPA 3DALA 3OOIA 3N71A 1MT6A 1XQHA 5T0KA 3RAYA 3CBPA 3M54A 1MVXA 1O9SA 3S7BA 4YNPA 3RQ4A 3MO5A 3CBOA 3RU0A 5JIYA 3F9WA 1MVHA 3OXFA 3M58A 4WUYA 4YPAA 5F6KC 4RZ0A 4LDGA 5ARGA 5EX3A 1ML9A 4YNMA 4NJ5A 4O30A 5JJ0A 3SWCA 2G46A 3M56A 5ARFA 3KMTA 5EG2A 3S8PA 1PEGA 3M53A 4C1QA 5AYFA 3M59A 3RIBA 4J7IA 4YPUA 4YNDA 5EX0A 3FPDA 4FMUA 5TH7A 3HNAA 5KJNA 4H12A 5F6LA 4IJDA 1ZKKA 5F5EA 3S7FA 4BUPA 3S7JA 1H3IA 3M55A 3RJWA 3MO0A 3F9YA 2QPWA 5TEGA 3DB5A 4MI5A 3QWVA 3IHXA 4JDSA 3PDNA 3TG4A 3QWWA 5LSXA 2JV0A 2F69A 3S7DA 5TTFA 3OPEA 5KJMA 3F9ZA 3OXLA 3OS5A 1MUFA 1N3JA 5CCMA 5T0MA 4QENA 5CCLA 5CPRB 3SW9A 4IJ8A 2BQZA 4AU7A 3CBMA 3TG5A 5T5GA 3M5AA 5F59A 4Z4PA 2RFIA 4J8OA 3F9XA 1N6CA 2R3AA 3BO5A 4E47A 2W5YA 5HQ8A 5HI7A 4YPEA 5KJKA 5LSZA 2W5ZA 4JLGA 3EP0A 4O6FA
chains in the Genus database with same CATH topology
4MI0A 3OXGA 4J83A 4J7FA 3MEKA 2IGQA 3KMAA 4NVQA 3VUZA 3QWPA 3K5KA 3KMJA 5KJLA 5JHNA 3MO2A 2O8JA 1N6AA 3M57A 4I51A 4QEOA 3VV0A 5JINA 4QEPA 3DALA 3OOIA 3N71A 1MT6A 1XQHA 5T0KA 3RAYA 3CBPA 3M54A 1MVXA 1O9SA 3S7BA 4YNPA 3RQ4A 3MO5A 3CBOA 3RU0A 5JIYA 3F9WA 1MVHA 3OXFA 3M58A 4WUYA 4YPAA 5F6KC 4RZ0A 4LDGA 5ARGA 5EX3A 1ML9A 4YNMA 4NJ5A 4O30A 5JJ0A 3SWCA 2G46A 3M56A 5ARFA 3KMTA 5EG2A 3S8PA 1PEGA 3M53A 4C1QA 5AYFA 3M59A 3RIBA 4J7IA 4YPUA 4YNDA 5EX0A 3FPDA 4FMUA 5TH7A 3HNAA 5KJNA 4H12A 5F6LA 4IJDA 1ZKKA 5F5EA 3S7FA 4BUPA 3S7JA 1H3IA 3M55A 3RJWA 3MO0A 3F9YA 2QPWA 5TEGA 3DB5A 4MI5A 3QWVA 3IHXA 4JDSA 3PDNA 3TG4A 3QWWA 5LSXA 2JV0A 2F69A 3S7DA 5TTFA 3OPEA 5KJMA 3F9ZA 3OXLA 3OS5A 1MUFA 1N3JA 5CCMA 5T0MA 4QENA 5CCLA 5CPRB 3SW9A 4IJ8A 2BQZA 4AU7A 3CBMA 3TG5A 5T5GA 3M5AA 5F59A 4Z4PA 2RFIA 4J8OA 3F9XA 1N6CA 2R3AA 3BO5A 4E47A 2W5YA 5HQ8A 5HI7A 4YPEA 5KJKA 5LSZA 2W5ZA 4JLGA 3EP0A 4O6FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MI0 A;  3OXG A;  4J83 A;  4J7F A;  3MEK A;  2IGQ A;  3KMA A;  4NVQ A;  3VUZ A;  3QWP A;  3K5K A;  3KMJ A;  5KJL A;  5JHN A;  3MO2 A;  2O8J A;  1N6A A;  3M57 A;  4I51 A;  4QEO A;  3VV0 A;  5JIN A;  4QEP A;  3DAL A;  3OOI A;  3N71 A;  1MT6 A;  1XQH A;  5T0K A;  3RAY A;  3CBP A;  3M54 A;  1MVX A;  1O9S A;  3S7B A;  4YNP A;  3RQ4 A;  3MO5 A;  3CBO A;  3RU0 A;  5JIY A;  3F9W A;  1MVH A;  3OXF A;  3M58 A;  4WUY A;  4YPA A;  5F6K C;  4RZ0 A;  4LDG A;  5ARG A;  5EX3 A;  1ML9 A;  4YNM A;  4NJ5 A;  4O30 A;  5JJ0 A;  3SWC A;  2G46 A;  3M56 A;  5ARF A;  3KMT A;  5EG2 A;  3S8P A;  1PEG A;  3M53 A;  4C1Q A;  5AYF A;  3M59 A;  3RIB A;  4J7I A;  4YPU A;  4YND A;  5EX0 A;  3FPD A;  4FMU A;  5TH7 A;  3HNA A;  5KJN A;  4H12 A;  5F6L A;  4IJD A;  1ZKK A;  5F5E A;  3S7F A;  4BUP A;  3S7J A;  1H3I A;  3M55 A;  3RJW A;  3MO0 A;  3F9Y A;  2QPW A;  5TEG A;  3DB5 A;  4MI5 A;  3QWV A;  3IHX A;  4JDS A;  3PDN A;  3TG4 A;  3QWW A;  5LSX A;  2JV0 A;  2F69 A;  3S7D A;  5TTF A;  3OPE A;  5KJM A;  3F9Z A;  3OXL A;  3OS5 A;  1MUF A;  1N3J A;  5CCM A;  5T0M A;  4QEN A;  5CCL A;  5CPR B;  3SW9 A;  4IJ8 A;  2BQZ A;  4AU7 A;  3CBM A;  3TG5 A;  5T5G A;  3M5A A;  5F59 A;  4Z4P A;  2RFI A;  4J8O A;  3F9X A;  1N6C A;  2R3A A;  3BO5 A;  4E47 A;  2W5Y A;  5HQ8 A;  5HI7 A;  4YPE A;  5KJK A;  5LSZ A;  2W5Z A;  4JLG A;  3EP0 A;  4O6F A; 
#chains in the Genus database with same CATH topology
 4MI0 A;  3OXG A;  4J83 A;  4J7F A;  3MEK A;  2IGQ A;  3KMA A;  4NVQ A;  3VUZ A;  3QWP A;  3K5K A;  3KMJ A;  5KJL A;  5JHN A;  3MO2 A;  2O8J A;  1N6A A;  3M57 A;  4I51 A;  4QEO A;  3VV0 A;  5JIN A;  4QEP A;  3DAL A;  3OOI A;  3N71 A;  1MT6 A;  1XQH A;  5T0K A;  3RAY A;  3CBP A;  3M54 A;  1MVX A;  1O9S A;  3S7B A;  4YNP A;  3RQ4 A;  3MO5 A;  3CBO A;  3RU0 A;  5JIY A;  3F9W A;  1MVH A;  3OXF A;  3M58 A;  4WUY A;  4YPA A;  5F6K C;  4RZ0 A;  4LDG A;  5ARG A;  5EX3 A;  1ML9 A;  4YNM A;  4NJ5 A;  4O30 A;  5JJ0 A;  3SWC A;  2G46 A;  3M56 A;  5ARF A;  3KMT A;  5EG2 A;  3S8P A;  1PEG A;  3M53 A;  4C1Q A;  5AYF A;  3M59 A;  3RIB A;  4J7I A;  4YPU A;  4YND A;  5EX0 A;  3FPD A;  4FMU A;  5TH7 A;  3HNA A;  5KJN A;  4H12 A;  5F6L A;  4IJD A;  1ZKK A;  5F5E A;  3S7F A;  4BUP A;  3S7J A;  1H3I A;  3M55 A;  3RJW A;  3MO0 A;  3F9Y A;  2QPW A;  5TEG A;  3DB5 A;  4MI5 A;  3QWV A;  3IHX A;  4JDS A;  3PDN A;  3TG4 A;  3QWW A;  5LSX A;  2JV0 A;  2F69 A;  3S7D A;  5TTF A;  3OPE A;  5KJM A;  3F9Z A;  3OXL A;  3OS5 A;  1MUF A;  1N3J A;  5CCM A;  5T0M A;  4QEN A;  5CCL A;  5CPR B;  3SW9 A;  4IJ8 A;  2BQZ A;  4AU7 A;  3CBM A;  3TG5 A;  5T5G A;  3M5A A;  5F59 A;  4Z4P A;  2RFI A;  4J8O A;  3F9X A;  1N6C A;  2R3A A;  3BO5 A;  4E47 A;  2W5Y A;  5HQ8 A;  5HI7 A;  4YPE A;  5KJK A;  5LSZ A;  2W5Z A;  4JLG A;  3EP0 A;  4O6F A; 
#chains in the Genus database with same CATH homology
 4MI0 A;  3OXG A;  4J83 A;  4J7F A;  3MEK A;  2IGQ A;  3KMA A;  4NVQ A;  3VUZ A;  3QWP A;  3K5K A;  3KMJ A;  5KJL A;  5JHN A;  3MO2 A;  2O8J A;  1N6A A;  3M57 A;  4I51 A;  4QEO A;  3VV0 A;  5JIN A;  4QEP A;  3DAL A;  3OOI A;  3N71 A;  1MT6 A;  1XQH A;  5T0K A;  3RAY A;  3CBP A;  3M54 A;  1MVX A;  1O9S A;  3S7B A;  4YNP A;  3RQ4 A;  3MO5 A;  3CBO A;  3RU0 A;  5JIY A;  3F9W A;  1MVH A;  3OXF A;  3M58 A;  4WUY A;  4YPA A;  5F6K C;  4RZ0 A;  4LDG A;  5ARG A;  5EX3 A;  1ML9 A;  4YNM A;  4NJ5 A;  4O30 A;  5JJ0 A;  3SWC A;  2G46 A;  3M56 A;  5ARF A;  3KMT A;  5EG2 A;  3S8P A;  1PEG A;  3M53 A;  4C1Q A;  5AYF A;  3M59 A;  3RIB A;  4J7I A;  4YPU A;  4YND A;  5EX0 A;  3FPD A;  4FMU A;  5TH7 A;  3HNA A;  5KJN A;  4H12 A;  5F6L A;  4IJD A;  1ZKK A;  5F5E A;  3S7F A;  4BUP A;  3S7J A;  1H3I A;  3M55 A;  3RJW A;  3MO0 A;  3F9Y A;  2QPW A;  5TEG A;  3DB5 A;  4MI5 A;  3QWV A;  3IHX A;  4JDS A;  3PDN A;  3TG4 A;  3QWW A;  5LSX A;  2JV0 A;  2F69 A;  3S7D A;  5TTF A;  3OPE A;  5KJM A;  3F9Z A;  3OXL A;  3OS5 A;  1MUF A;  1N3J A;  5CCM A;  5T0M A;  4QEN A;  5CCL A;  5CPR B;  3SW9 A;  4IJ8 A;  2BQZ A;  4AU7 A;  3CBM A;  3TG5 A;  5T5G A;  3M5A A;  5F59 A;  4Z4P A;  2RFI A;  4J8O A;  3F9X A;  1N6C A;  2R3A A;  3BO5 A;  4E47 A;  2W5Y A;  5HQ8 A;  5HI7 A;  4YPE A;  5KJK A;  5LSZ A;  2W5Z A;  4JLG A;  3EP0 A;  4O6F A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...