5T0MA

A histone h3k9m mutation traps histone methyltransferase clr4 to prevent heterochromatin spreading
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
264
structure length
260
Chain Sequence
IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
total genus 70
structure length 260
sequence length 264
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0mA00
4LDGA 5TH7A 4FMUA 3N71A 3CBMA 2G46A 5AYFA 4J7FA 2R3AA 4MI0A 3MO0A 3OXLA 3F9WA 5ARFA 5EG2A 3KMJA 5F6KC 3S7JA 4QENA 2RFIA 3EP0A 4YPEA 3TG4A 5F5EA 3FPDA 2JV0A 1MT6A 3QWWA 5JJ0A 4H12A 4NVQA 3M57A 5TEGA 3IHXA 4QEPA 3VV0A 3CBPA 5F6LA 3K5KA 3MO5A 3RU0A 5CCMA 4YNDA 4QEOA 3OXFA 1O9SA 4YPUA 5CCLA 3DB5A 2O8JA 4JDSA 5T5GA 1ZKKA 3F9ZA 2IGQA 3F9YA 4JLGA 4MI5A 5JHNA 5HI7A 3RJWA 3RQ4A 3MEKA 3SW9A 3SWCA 3S8PA 1ML9A 5CPRB 1N3JA 2QPWA 5EX3A 4O6FA 1PEGA 5ARGA 3QWVA 3OPEA 3M54A 3M5AA 4O30A 3M56A 4IJDA 4Z4PA 3M55A 5LSXA 3F9XA 4WUYA 4E47A 4J8OA 3TG5A 3VUZA 5KJLA 4I51A 5LSZA 2F69A 3M58A 2BQZA 3QWPA 5T0MA 1H3IA 1XQHA 3M59A 3OXGA 5KJMA 3DALA 1N6AA 3M53A 5EX0A 4BUPA 3PDNA 3OS5A 2W5YA 5KJKA 4IJ8A 4YPAA 3MO2A 1MVHA 1N6CA 4J7IA 4YNPA 4NJ5A 3RIBA 3BO5A 5F59A 3S7FA 5KJNA 3KMAA 3KMTA 1MUFA 3CBOA 3OOIA 2W5ZA 5TTFA 4AU7A 5JIYA 3S7BA 5JINA 3RAYA 5T0KA 1MVXA 4J83A 5HQ8A 4YNMA 4C1QA 3S7DA 3HNAA 4RZ0A
chains in the Genus database with same CATH superfamily
4LDGA 5TH7A 4FMUA 3N71A 3CBMA 2G46A 5AYFA 4J7FA 2R3AA 4MI0A 3MO0A 3OXLA 3F9WA 5ARFA 5EG2A 3KMJA 5F6KC 3S7JA 4QENA 2RFIA 3EP0A 4YPEA 3TG4A 5F5EA 3FPDA 2JV0A 1MT6A 3QWWA 5JJ0A 4H12A 4NVQA 3M57A 5TEGA 3IHXA 4QEPA 3VV0A 3CBPA 5F6LA 3K5KA 3MO5A 3RU0A 5CCMA 4YNDA 4QEOA 3OXFA 1O9SA 4YPUA 5CCLA 3DB5A 2O8JA 4JDSA 5T5GA 1ZKKA 3F9ZA 2IGQA 3F9YA 4JLGA 4MI5A 5JHNA 5HI7A 3RJWA 3RQ4A 3MEKA 3SW9A 3SWCA 3S8PA 1ML9A 5CPRB 1N3JA 2QPWA 5EX3A 4O6FA 1PEGA 5ARGA 3QWVA 3OPEA 3M54A 3M5AA 4O30A 3M56A 4IJDA 4Z4PA 3M55A 5LSXA 3F9XA 4WUYA 4E47A 4J8OA 3TG5A 3VUZA 5KJLA 4I51A 5LSZA 2F69A 3M58A 2BQZA 3QWPA 5T0MA 1H3IA 1XQHA 3M59A 3OXGA 5KJMA 3DALA 1N6AA 3M53A 5EX0A 4BUPA 3PDNA 3OS5A 2W5YA 5KJKA 4IJ8A 4YPAA 3MO2A 1MVHA 1N6CA 4J7IA 4YNPA 4NJ5A 3RIBA 3BO5A 5F59A 3S7FA 5KJNA 3KMAA 3KMTA 1MUFA 3CBOA 3OOIA 2W5ZA 5TTFA 4AU7A 5JIYA 3S7BA 5JINA 3RAYA 5T0KA 1MVXA 4J83A 5HQ8A 4YNMA 4C1QA 3S7DA 3HNAA 4RZ0A
chains in the Genus database with same CATH topology
4LDGA 5TH7A 4FMUA 3N71A 3CBMA 2G46A 5AYFA 4J7FA 2R3AA 4MI0A 3MO0A 3OXLA 3F9WA 5ARFA 5EG2A 3KMJA 5F6KC 3S7JA 4QENA 2RFIA 3EP0A 4YPEA 3TG4A 5F5EA 3FPDA 2JV0A 1MT6A 3QWWA 5JJ0A 4H12A 4NVQA 3M57A 5TEGA 3IHXA 4QEPA 3VV0A 3CBPA 5F6LA 3K5KA 3MO5A 3RU0A 5CCMA 4YNDA 4QEOA 3OXFA 1O9SA 4YPUA 5CCLA 3DB5A 2O8JA 4JDSA 5T5GA 1ZKKA 3F9ZA 2IGQA 3F9YA 4JLGA 4MI5A 5JHNA 5HI7A 3RJWA 3RQ4A 3MEKA 3SW9A 3SWCA 3S8PA 1ML9A 5CPRB 1N3JA 2QPWA 5EX3A 4O6FA 1PEGA 5ARGA 3QWVA 3OPEA 3M54A 3M5AA 4O30A 3M56A 4IJDA 4Z4PA 3M55A 5LSXA 3F9XA 4WUYA 4E47A 4J8OA 3TG5A 3VUZA 5KJLA 4I51A 5LSZA 2F69A 3M58A 2BQZA 3QWPA 5T0MA 1H3IA 1XQHA 3M59A 3OXGA 5KJMA 3DALA 1N6AA 3M53A 5EX0A 4BUPA 3PDNA 3OS5A 2W5YA 5KJKA 4IJ8A 4YPAA 3MO2A 1MVHA 1N6CA 4J7IA 4YNPA 4NJ5A 3RIBA 3BO5A 5F59A 3S7FA 5KJNA 3KMAA 3KMTA 1MUFA 3CBOA 3OOIA 2W5ZA 5TTFA 4AU7A 5JIYA 3S7BA 5JINA 3RAYA 5T0KA 1MVXA 4J83A 5HQ8A 4YNMA 4C1QA 3S7DA 3HNAA 4RZ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LDG A;  5TH7 A;  4FMU A;  3N71 A;  3CBM A;  2G46 A;  5AYF A;  4J7F A;  2R3A A;  4MI0 A;  3MO0 A;  3OXL A;  3F9W A;  5ARF A;  5EG2 A;  3KMJ A;  5F6K C;  3S7J A;  4QEN A;  2RFI A;  3EP0 A;  4YPE A;  3TG4 A;  5F5E A;  3FPD A;  2JV0 A;  1MT6 A;  3QWW A;  5JJ0 A;  4H12 A;  4NVQ A;  3M57 A;  5TEG A;  3IHX A;  4QEP A;  3VV0 A;  3CBP A;  5F6L A;  3K5K A;  3MO5 A;  3RU0 A;  5CCM A;  4YND A;  4QEO A;  3OXF A;  1O9S A;  4YPU A;  5CCL A;  3DB5 A;  2O8J A;  4JDS A;  5T5G A;  1ZKK A;  3F9Z A;  2IGQ A;  3F9Y A;  4JLG A;  4MI5 A;  5JHN A;  5HI7 A;  3RJW A;  3RQ4 A;  3MEK A;  3SW9 A;  3SWC A;  3S8P A;  1ML9 A;  5CPR B;  1N3J A;  2QPW A;  5EX3 A;  4O6F A;  1PEG A;  5ARG A;  3QWV A;  3OPE A;  3M54 A;  3M5A A;  4O30 A;  3M56 A;  4IJD A;  4Z4P A;  3M55 A;  5LSX A;  3F9X A;  4WUY A;  4E47 A;  4J8O A;  3TG5 A;  3VUZ A;  5KJL A;  4I51 A;  5LSZ A;  2F69 A;  3M58 A;  2BQZ A;  3QWP A;  5T0M A;  1H3I A;  1XQH A;  3M59 A;  3OXG A;  5KJM A;  3DAL A;  1N6A A;  3M53 A;  5EX0 A;  4BUP A;  3PDN A;  3OS5 A;  2W5Y A;  5KJK A;  4IJ8 A;  4YPA A;  3MO2 A;  1MVH A;  1N6C A;  4J7I A;  4YNP A;  4NJ5 A;  3RIB A;  3BO5 A;  5F59 A;  3S7F A;  5KJN A;  3KMA A;  3KMT A;  1MUF A;  3CBO A;  3OOI A;  2W5Z A;  5TTF A;  4AU7 A;  5JIY A;  3S7B A;  5JIN A;  3RAY A;  5T0K A;  1MVX A;  4J83 A;  5HQ8 A;  4YNM A;  4C1Q A;  3S7D A;  3HNA A;  4RZ0 A; 
#chains in the Genus database with same CATH topology
 4LDG A;  5TH7 A;  4FMU A;  3N71 A;  3CBM A;  2G46 A;  5AYF A;  4J7F A;  2R3A A;  4MI0 A;  3MO0 A;  3OXL A;  3F9W A;  5ARF A;  5EG2 A;  3KMJ A;  5F6K C;  3S7J A;  4QEN A;  2RFI A;  3EP0 A;  4YPE A;  3TG4 A;  5F5E A;  3FPD A;  2JV0 A;  1MT6 A;  3QWW A;  5JJ0 A;  4H12 A;  4NVQ A;  3M57 A;  5TEG A;  3IHX A;  4QEP A;  3VV0 A;  3CBP A;  5F6L A;  3K5K A;  3MO5 A;  3RU0 A;  5CCM A;  4YND A;  4QEO A;  3OXF A;  1O9S A;  4YPU A;  5CCL A;  3DB5 A;  2O8J A;  4JDS A;  5T5G A;  1ZKK A;  3F9Z A;  2IGQ A;  3F9Y A;  4JLG A;  4MI5 A;  5JHN A;  5HI7 A;  3RJW A;  3RQ4 A;  3MEK A;  3SW9 A;  3SWC A;  3S8P A;  1ML9 A;  5CPR B;  1N3J A;  2QPW A;  5EX3 A;  4O6F A;  1PEG A;  5ARG A;  3QWV A;  3OPE A;  3M54 A;  3M5A A;  4O30 A;  3M56 A;  4IJD A;  4Z4P A;  3M55 A;  5LSX A;  3F9X A;  4WUY A;  4E47 A;  4J8O A;  3TG5 A;  3VUZ A;  5KJL A;  4I51 A;  5LSZ A;  2F69 A;  3M58 A;  2BQZ A;  3QWP A;  5T0M A;  1H3I A;  1XQH A;  3M59 A;  3OXG A;  5KJM A;  3DAL A;  1N6A A;  3M53 A;  5EX0 A;  4BUP A;  3PDN A;  3OS5 A;  2W5Y A;  5KJK A;  4IJ8 A;  4YPA A;  3MO2 A;  1MVH A;  1N6C A;  4J7I A;  4YNP A;  4NJ5 A;  3RIB A;  3BO5 A;  5F59 A;  3S7F A;  5KJN A;  3KMA A;  3KMT A;  1MUF A;  3CBO A;  3OOI A;  2W5Z A;  5TTF A;  4AU7 A;  5JIY A;  3S7B A;  5JIN A;  3RAY A;  5T0K A;  1MVX A;  4J83 A;  5HQ8 A;  4YNM A;  4C1Q A;  3S7D A;  3HNA A;  4RZ0 A; 
#chains in the Genus database with same CATH homology
 4LDG A;  5TH7 A;  4FMU A;  3N71 A;  3CBM A;  2G46 A;  5AYF A;  4J7F A;  2R3A A;  4MI0 A;  3MO0 A;  3OXL A;  3F9W A;  5ARF A;  5EG2 A;  3KMJ A;  5F6K C;  3S7J A;  4QEN A;  2RFI A;  3EP0 A;  4YPE A;  3TG4 A;  5F5E A;  3FPD A;  2JV0 A;  1MT6 A;  3QWW A;  5JJ0 A;  4H12 A;  4NVQ A;  3M57 A;  5TEG A;  3IHX A;  4QEP A;  3VV0 A;  3CBP A;  5F6L A;  3K5K A;  3MO5 A;  3RU0 A;  5CCM A;  4YND A;  4QEO A;  3OXF A;  1O9S A;  4YPU A;  5CCL A;  3DB5 A;  2O8J A;  4JDS A;  5T5G A;  1ZKK A;  3F9Z A;  2IGQ A;  3F9Y A;  4JLG A;  4MI5 A;  5JHN A;  5HI7 A;  3RJW A;  3RQ4 A;  3MEK A;  3SW9 A;  3SWC A;  3S8P A;  1ML9 A;  5CPR B;  1N3J A;  2QPW A;  5EX3 A;  4O6F A;  1PEG A;  5ARG A;  3QWV A;  3OPE A;  3M54 A;  3M5A A;  4O30 A;  3M56 A;  4IJD A;  4Z4P A;  3M55 A;  5LSX A;  3F9X A;  4WUY A;  4E47 A;  4J8O A;  3TG5 A;  3VUZ A;  5KJL A;  4I51 A;  5LSZ A;  2F69 A;  3M58 A;  2BQZ A;  3QWP A;  5T0M A;  1H3I A;  1XQH A;  3M59 A;  3OXG A;  5KJM A;  3DAL A;  1N6A A;  3M53 A;  5EX0 A;  4BUP A;  3PDN A;  3OS5 A;  2W5Y A;  5KJK A;  4IJ8 A;  4YPA A;  3MO2 A;  1MVH A;  1N6C A;  4J7I A;  4YNP A;  4NJ5 A;  3RIB A;  3BO5 A;  5F59 A;  3S7F A;  5KJN A;  3KMA A;  3KMT A;  1MUF A;  3CBO A;  3OOI A;  2W5Z A;  5TTF A;  4AU7 A;  5JIY A;  3S7B A;  5JIN A;  3RAY A;  5T0K A;  1MVX A;  4J83 A;  5HQ8 A;  4YNM A;  4C1Q A;  3S7D A;  3HNA A;  4RZ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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