5T0MA

A histone h3k9m mutation traps histone methyltransferase clr4 to prevent heterochromatin spreading
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
264
structure length
260
Chain Sequence
IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 70
structure length 260
sequence length 264
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0mA00
2O8JA 5CPRB 1ZKKA 5F59A 3S7JA 1N6CA 4J8OA 3QWPA 5EX3A 1PEGA 4RZ0A 5T5GA 5HI7A 3CBMA 5TH7A 4FMUA 3S7DA 3SW9A 3TG4A 4YNPA 4BUPA 4NJ5A 5EX0A 5LSXA 4J7IA 3BO5A 1ML9A 1XQHA 4J7FA 5KJMA 5T0KA 4MI5A 2RFIA 3RAYA 3OPEA 3SWCA 3MO2A 5TEGA 3VV0A 4J83A 5KJLA 1O9SA 3RIBA 5CCMA 2IGQA 1MUFA 4QEPA 3N71A 4WUYA 1H3IA 3F9WA 3M55A 2G46A 1MT6A 3RU0A 3CBPA 3K5KA 4YNDA 4AU7A 2W5ZA 4E47A 2F69A 5AYFA 3MO5A 3KMAA 2JV0A 4Z4PA 3M5AA 3KMTA 3VUZA 5JIYA 5ARFA 3M53A 3M58A 4IJ8A 4IJDA 3S7FA 3OOIA 4YPUA 4QEOA 3QWVA 3EP0A 1N6AA 3RJWA 1N3JA 4NVQA 3DALA 5ARGA 3F9ZA 4YPEA 2BQZA 5EG2A 3MEKA 4LDGA 5JHNA 5LSZA 3S8PA 4JLGA 4QENA 4I51A 3S7BA 3PDNA 2W5YA 3IHXA 5HQ8A 3M54A 5TTFA 3OXFA 4MI0A 3TG5A 3MO0A 3DB5A 4O30A 4JDSA 5CCLA 3M59A 3OXLA 5JINA 5JJ0A 1MVXA 3KMJA 4YNMA 3QWWA 5F6LA 5F5EA 4C1QA 1MVHA 4YPAA 3OS5A 4H12A 5F6KC 3FPDA 5T0MA 4O6FA 3M57A 3CBOA 3M56A 3OXGA 2QPWA 5KJKA 2R3AA 5KJNA 3RQ4A 3HNAA 3F9XA 3F9YA
chains in the Genus database with same CATH superfamily
2O8JA 5CPRB 1ZKKA 5F59A 3S7JA 1N6CA 4J8OA 3QWPA 5EX3A 1PEGA 4RZ0A 5T5GA 5HI7A 3CBMA 5TH7A 4FMUA 3S7DA 3SW9A 3TG4A 4YNPA 4BUPA 4NJ5A 5EX0A 5LSXA 4J7IA 3BO5A 1ML9A 1XQHA 4J7FA 5KJMA 5T0KA 4MI5A 2RFIA 3RAYA 3OPEA 3SWCA 3MO2A 5TEGA 3VV0A 4J83A 5KJLA 1O9SA 3RIBA 5CCMA 2IGQA 1MUFA 4QEPA 3N71A 4WUYA 1H3IA 3F9WA 3M55A 2G46A 1MT6A 3RU0A 3CBPA 3K5KA 4YNDA 4AU7A 2W5ZA 4E47A 2F69A 5AYFA 3MO5A 3KMAA 2JV0A 4Z4PA 3M5AA 3KMTA 3VUZA 5JIYA 5ARFA 3M53A 3M58A 4IJ8A 4IJDA 3S7FA 3OOIA 4YPUA 4QEOA 3QWVA 3EP0A 1N6AA 3RJWA 1N3JA 4NVQA 3DALA 5ARGA 3F9ZA 4YPEA 2BQZA 5EG2A 3MEKA 4LDGA 5JHNA 5LSZA 3S8PA 4JLGA 4QENA 4I51A 3S7BA 3PDNA 2W5YA 3IHXA 5HQ8A 3M54A 5TTFA 3OXFA 4MI0A 3TG5A 3MO0A 3DB5A 4O30A 4JDSA 5CCLA 3M59A 3OXLA 5JINA 5JJ0A 1MVXA 3KMJA 4YNMA 3QWWA 5F6LA 5F5EA 4C1QA 1MVHA 4YPAA 3OS5A 4H12A 5F6KC 3FPDA 5T0MA 4O6FA 3M57A 3CBOA 3M56A 3OXGA 2QPWA 5KJKA 2R3AA 5KJNA 3RQ4A 3HNAA 3F9XA 3F9YA
chains in the Genus database with same CATH topology
2O8JA 5CPRB 1ZKKA 5F59A 3S7JA 1N6CA 4J8OA 3QWPA 5EX3A 1PEGA 4RZ0A 5T5GA 5HI7A 3CBMA 5TH7A 4FMUA 3S7DA 3SW9A 3TG4A 4YNPA 4BUPA 4NJ5A 5EX0A 5LSXA 4J7IA 3BO5A 1ML9A 1XQHA 4J7FA 5KJMA 5T0KA 4MI5A 2RFIA 3RAYA 3OPEA 3SWCA 3MO2A 5TEGA 3VV0A 4J83A 5KJLA 1O9SA 3RIBA 5CCMA 2IGQA 1MUFA 4QEPA 3N71A 4WUYA 1H3IA 3F9WA 3M55A 2G46A 1MT6A 3RU0A 3CBPA 3K5KA 4YNDA 4AU7A 2W5ZA 4E47A 2F69A 5AYFA 3MO5A 3KMAA 2JV0A 4Z4PA 3M5AA 3KMTA 3VUZA 5JIYA 5ARFA 3M53A 3M58A 4IJ8A 4IJDA 3S7FA 3OOIA 4YPUA 4QEOA 3QWVA 3EP0A 1N6AA 3RJWA 1N3JA 4NVQA 3DALA 5ARGA 3F9ZA 4YPEA 2BQZA 5EG2A 3MEKA 4LDGA 5JHNA 5LSZA 3S8PA 4JLGA 4QENA 4I51A 3S7BA 3PDNA 2W5YA 3IHXA 5HQ8A 3M54A 5TTFA 3OXFA 4MI0A 3TG5A 3MO0A 3DB5A 4O30A 4JDSA 5CCLA 3M59A 3OXLA 5JINA 5JJ0A 1MVXA 3KMJA 4YNMA 3QWWA 5F6LA 5F5EA 4C1QA 1MVHA 4YPAA 3OS5A 4H12A 5F6KC 3FPDA 5T0MA 4O6FA 3M57A 3CBOA 3M56A 3OXGA 2QPWA 5KJKA 2R3AA 5KJNA 3RQ4A 3HNAA 3F9XA 3F9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O8J A;  5CPR B;  1ZKK A;  5F59 A;  3S7J A;  1N6C A;  4J8O A;  3QWP A;  5EX3 A;  1PEG A;  4RZ0 A;  5T5G A;  5HI7 A;  3CBM A;  5TH7 A;  4FMU A;  3S7D A;  3SW9 A;  3TG4 A;  4YNP A;  4BUP A;  4NJ5 A;  5EX0 A;  5LSX A;  4J7I A;  3BO5 A;  1ML9 A;  1XQH A;  4J7F A;  5KJM A;  5T0K A;  4MI5 A;  2RFI A;  3RAY A;  3OPE A;  3SWC A;  3MO2 A;  5TEG A;  3VV0 A;  4J83 A;  5KJL A;  1O9S A;  3RIB A;  5CCM A;  2IGQ A;  1MUF A;  4QEP A;  3N71 A;  4WUY A;  1H3I A;  3F9W A;  3M55 A;  2G46 A;  1MT6 A;  3RU0 A;  3CBP A;  3K5K A;  4YND A;  4AU7 A;  2W5Z A;  4E47 A;  2F69 A;  5AYF A;  3MO5 A;  3KMA A;  2JV0 A;  4Z4P A;  3M5A A;  3KMT A;  3VUZ A;  5JIY A;  5ARF A;  3M53 A;  3M58 A;  4IJ8 A;  4IJD A;  3S7F A;  3OOI A;  4YPU A;  4QEO A;  3QWV A;  3EP0 A;  1N6A A;  3RJW A;  1N3J A;  4NVQ A;  3DAL A;  5ARG A;  3F9Z A;  4YPE A;  2BQZ A;  5EG2 A;  3MEK A;  4LDG A;  5JHN A;  5LSZ A;  3S8P A;  4JLG A;  4QEN A;  4I51 A;  3S7B A;  3PDN A;  2W5Y A;  3IHX A;  5HQ8 A;  3M54 A;  5TTF A;  3OXF A;  4MI0 A;  3TG5 A;  3MO0 A;  3DB5 A;  4O30 A;  4JDS A;  5CCL A;  3M59 A;  3OXL A;  5JIN A;  5JJ0 A;  1MVX A;  3KMJ A;  4YNM A;  3QWW A;  5F6L A;  5F5E A;  4C1Q A;  1MVH A;  4YPA A;  3OS5 A;  4H12 A;  5F6K C;  3FPD A;  5T0M A;  4O6F A;  3M57 A;  3CBO A;  3M56 A;  3OXG A;  2QPW A;  5KJK A;  2R3A A;  5KJN A;  3RQ4 A;  3HNA A;  3F9X A;  3F9Y A; 
#chains in the Genus database with same CATH topology
 2O8J A;  5CPR B;  1ZKK A;  5F59 A;  3S7J A;  1N6C A;  4J8O A;  3QWP A;  5EX3 A;  1PEG A;  4RZ0 A;  5T5G A;  5HI7 A;  3CBM A;  5TH7 A;  4FMU A;  3S7D A;  3SW9 A;  3TG4 A;  4YNP A;  4BUP A;  4NJ5 A;  5EX0 A;  5LSX A;  4J7I A;  3BO5 A;  1ML9 A;  1XQH A;  4J7F A;  5KJM A;  5T0K A;  4MI5 A;  2RFI A;  3RAY A;  3OPE A;  3SWC A;  3MO2 A;  5TEG A;  3VV0 A;  4J83 A;  5KJL A;  1O9S A;  3RIB A;  5CCM A;  2IGQ A;  1MUF A;  4QEP A;  3N71 A;  4WUY A;  1H3I A;  3F9W A;  3M55 A;  2G46 A;  1MT6 A;  3RU0 A;  3CBP A;  3K5K A;  4YND A;  4AU7 A;  2W5Z A;  4E47 A;  2F69 A;  5AYF A;  3MO5 A;  3KMA A;  2JV0 A;  4Z4P A;  3M5A A;  3KMT A;  3VUZ A;  5JIY A;  5ARF A;  3M53 A;  3M58 A;  4IJ8 A;  4IJD A;  3S7F A;  3OOI A;  4YPU A;  4QEO A;  3QWV A;  3EP0 A;  1N6A A;  3RJW A;  1N3J A;  4NVQ A;  3DAL A;  5ARG A;  3F9Z A;  4YPE A;  2BQZ A;  5EG2 A;  3MEK A;  4LDG A;  5JHN A;  5LSZ A;  3S8P A;  4JLG A;  4QEN A;  4I51 A;  3S7B A;  3PDN A;  2W5Y A;  3IHX A;  5HQ8 A;  3M54 A;  5TTF A;  3OXF A;  4MI0 A;  3TG5 A;  3MO0 A;  3DB5 A;  4O30 A;  4JDS A;  5CCL A;  3M59 A;  3OXL A;  5JIN A;  5JJ0 A;  1MVX A;  3KMJ A;  4YNM A;  3QWW A;  5F6L A;  5F5E A;  4C1Q A;  1MVH A;  4YPA A;  3OS5 A;  4H12 A;  5F6K C;  3FPD A;  5T0M A;  4O6F A;  3M57 A;  3CBO A;  3M56 A;  3OXG A;  2QPW A;  5KJK A;  2R3A A;  5KJN A;  3RQ4 A;  3HNA A;  3F9X A;  3F9Y A; 
#chains in the Genus database with same CATH homology
 2O8J A;  5CPR B;  1ZKK A;  5F59 A;  3S7J A;  1N6C A;  4J8O A;  3QWP A;  5EX3 A;  1PEG A;  4RZ0 A;  5T5G A;  5HI7 A;  3CBM A;  5TH7 A;  4FMU A;  3S7D A;  3SW9 A;  3TG4 A;  4YNP A;  4BUP A;  4NJ5 A;  5EX0 A;  5LSX A;  4J7I A;  3BO5 A;  1ML9 A;  1XQH A;  4J7F A;  5KJM A;  5T0K A;  4MI5 A;  2RFI A;  3RAY A;  3OPE A;  3SWC A;  3MO2 A;  5TEG A;  3VV0 A;  4J83 A;  5KJL A;  1O9S A;  3RIB A;  5CCM A;  2IGQ A;  1MUF A;  4QEP A;  3N71 A;  4WUY A;  1H3I A;  3F9W A;  3M55 A;  2G46 A;  1MT6 A;  3RU0 A;  3CBP A;  3K5K A;  4YND A;  4AU7 A;  2W5Z A;  4E47 A;  2F69 A;  5AYF A;  3MO5 A;  3KMA A;  2JV0 A;  4Z4P A;  3M5A A;  3KMT A;  3VUZ A;  5JIY A;  5ARF A;  3M53 A;  3M58 A;  4IJ8 A;  4IJD A;  3S7F A;  3OOI A;  4YPU A;  4QEO A;  3QWV A;  3EP0 A;  1N6A A;  3RJW A;  1N3J A;  4NVQ A;  3DAL A;  5ARG A;  3F9Z A;  4YPE A;  2BQZ A;  5EG2 A;  3MEK A;  4LDG A;  5JHN A;  5LSZ A;  3S8P A;  4JLG A;  4QEN A;  4I51 A;  3S7B A;  3PDN A;  2W5Y A;  3IHX A;  5HQ8 A;  3M54 A;  5TTF A;  3OXF A;  4MI0 A;  3TG5 A;  3MO0 A;  3DB5 A;  4O30 A;  4JDS A;  5CCL A;  3M59 A;  3OXL A;  5JIN A;  5JJ0 A;  1MVX A;  3KMJ A;  4YNM A;  3QWW A;  5F6L A;  5F5E A;  4C1Q A;  1MVH A;  4YPA A;  3OS5 A;  4H12 A;  5F6K C;  3FPD A;  5T0M A;  4O6F A;  3M57 A;  3CBO A;  3M56 A;  3OXG A;  2QPW A;  5KJK A;  2R3A A;  5KJN A;  3RQ4 A;  3HNA A;  3F9X A;  3F9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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