5T0MA

A histone h3k9m mutation traps histone methyltransferase clr4 to prevent heterochromatin spreading
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
264
structure length
260
Chain Sequence
IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 70
structure length 260
sequence length 264
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5t0mA00
3M5AA 4YNDA 3RIBA 3VUZA 4BUPA 4J8OA 4JLGA 3M54A 1PEGA 4NJ5A 1H3IA 3FPDA 4MI5A 4Z4PA 4YNMA 2BQZA 5TTFA 3M59A 3S7BA 3OOIA 3CBMA 5LSZA 4YPEA 2W5YA 3KMTA 3S7JA 5T0MA 4MI0A 3MO0A 3F9XA 5JIYA 5EX0A 5TEGA 5F59A 3OXLA 4QEOA 3IHXA 3SW9A 5HI7A 5KJLA 2R3AA 4O6FA 4YPAA 1XQHA 3DB5A 3SWCA 1MVHA 4AU7A 1O9SA 5JHNA 3MO2A 4RZ0A 5CPRB 4C1QA 3MO5A 1MVXA 5T5GA 3CBOA 5EG2A 3CBPA 2G46A 3F9WA 3M57A 3MEKA 3TG5A 3QWPA 4H12A 4IJ8A 4YNPA 5T0KA 1N6AA 4J7IA 2F69A 3OPEA 5CCMA 3PDNA 3RJWA 3QWVA 3VV0A 3RU0A 4WUYA 3M53A 3F9ZA 4NVQA 4QEPA 5F5EA 3OXFA 1MUFA 5AYFA 3F9YA 3BO5A 3S8PA 5F6LA 5EX3A 5ARFA 4J83A 3RAYA 3S7FA 1ZKKA 2W5ZA 3M56A 3TG4A 4I51A 1N3JA 5TH7A 2IGQA 1MT6A 3KMJA 3KMAA 4E47A 4IJDA 3N71A 2O8JA 3QWWA 5HQ8A 2RFIA 5CCLA 3M58A 4LDGA 4QENA 5KJNA 2QPWA 4FMUA 4JDSA 3OS5A 4J7FA 3HNAA 4O30A 5JINA 5LSXA 2JV0A 1N6CA 3OXGA 3M55A 3EP0A 1ML9A 3K5KA 5F6KC 5JJ0A 5ARGA 3S7DA 3DALA 4YPUA 5KJMA 3RQ4A 5KJKA
chains in the Genus database with same CATH superfamily
3M5AA 4YNDA 3RIBA 3VUZA 4BUPA 4J8OA 4JLGA 3M54A 1PEGA 4NJ5A 1H3IA 3FPDA 4MI5A 4Z4PA 4YNMA 2BQZA 5TTFA 3M59A 3S7BA 3OOIA 3CBMA 5LSZA 4YPEA 2W5YA 3KMTA 3S7JA 5T0MA 4MI0A 3MO0A 3F9XA 5JIYA 5EX0A 5TEGA 5F59A 3OXLA 4QEOA 3IHXA 3SW9A 5HI7A 5KJLA 2R3AA 4O6FA 4YPAA 1XQHA 3DB5A 3SWCA 1MVHA 4AU7A 1O9SA 5JHNA 3MO2A 4RZ0A 5CPRB 4C1QA 3MO5A 1MVXA 5T5GA 3CBOA 5EG2A 3CBPA 2G46A 3F9WA 3M57A 3MEKA 3TG5A 3QWPA 4H12A 4IJ8A 4YNPA 5T0KA 1N6AA 4J7IA 2F69A 3OPEA 5CCMA 3PDNA 3RJWA 3QWVA 3VV0A 3RU0A 4WUYA 3M53A 3F9ZA 4NVQA 4QEPA 5F5EA 3OXFA 1MUFA 5AYFA 3F9YA 3BO5A 3S8PA 5F6LA 5EX3A 5ARFA 4J83A 3RAYA 3S7FA 1ZKKA 2W5ZA 3M56A 3TG4A 4I51A 1N3JA 5TH7A 2IGQA 1MT6A 3KMJA 3KMAA 4E47A 4IJDA 3N71A 2O8JA 3QWWA 5HQ8A 2RFIA 5CCLA 3M58A 4LDGA 4QENA 5KJNA 2QPWA 4FMUA 4JDSA 3OS5A 4J7FA 3HNAA 4O30A 5JINA 5LSXA 2JV0A 1N6CA 3OXGA 3M55A 3EP0A 1ML9A 3K5KA 5F6KC 5JJ0A 5ARGA 3S7DA 3DALA 4YPUA 5KJMA 3RQ4A 5KJKA
chains in the Genus database with same CATH topology
3M5AA 4YNDA 3RIBA 3VUZA 4BUPA 4J8OA 4JLGA 3M54A 1PEGA 4NJ5A 1H3IA 3FPDA 4MI5A 4Z4PA 4YNMA 2BQZA 5TTFA 3M59A 3S7BA 3OOIA 3CBMA 5LSZA 4YPEA 2W5YA 3KMTA 3S7JA 5T0MA 4MI0A 3MO0A 3F9XA 5JIYA 5EX0A 5TEGA 5F59A 3OXLA 4QEOA 3IHXA 3SW9A 5HI7A 5KJLA 2R3AA 4O6FA 4YPAA 1XQHA 3DB5A 3SWCA 1MVHA 4AU7A 1O9SA 5JHNA 3MO2A 4RZ0A 5CPRB 4C1QA 3MO5A 1MVXA 5T5GA 3CBOA 5EG2A 3CBPA 2G46A 3F9WA 3M57A 3MEKA 3TG5A 3QWPA 4H12A 4IJ8A 4YNPA 5T0KA 1N6AA 4J7IA 2F69A 3OPEA 5CCMA 3PDNA 3RJWA 3QWVA 3VV0A 3RU0A 4WUYA 3M53A 3F9ZA 4NVQA 4QEPA 5F5EA 3OXFA 1MUFA 5AYFA 3F9YA 3BO5A 3S8PA 5F6LA 5EX3A 5ARFA 4J83A 3RAYA 3S7FA 1ZKKA 2W5ZA 3M56A 3TG4A 4I51A 1N3JA 5TH7A 2IGQA 1MT6A 3KMJA 3KMAA 4E47A 4IJDA 3N71A 2O8JA 3QWWA 5HQ8A 2RFIA 5CCLA 3M58A 4LDGA 4QENA 5KJNA 2QPWA 4FMUA 4JDSA 3OS5A 4J7FA 3HNAA 4O30A 5JINA 5LSXA 2JV0A 1N6CA 3OXGA 3M55A 3EP0A 1ML9A 3K5KA 5F6KC 5JJ0A 5ARGA 3S7DA 3DALA 4YPUA 5KJMA 3RQ4A 5KJKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M5A A;  4YND A;  3RIB A;  3VUZ A;  4BUP A;  4J8O A;  4JLG A;  3M54 A;  1PEG A;  4NJ5 A;  1H3I A;  3FPD A;  4MI5 A;  4Z4P A;  4YNM A;  2BQZ A;  5TTF A;  3M59 A;  3S7B A;  3OOI A;  3CBM A;  5LSZ A;  4YPE A;  2W5Y A;  3KMT A;  3S7J A;  5T0M A;  4MI0 A;  3MO0 A;  3F9X A;  5JIY A;  5EX0 A;  5TEG A;  5F59 A;  3OXL A;  4QEO A;  3IHX A;  3SW9 A;  5HI7 A;  5KJL A;  2R3A A;  4O6F A;  4YPA A;  1XQH A;  3DB5 A;  3SWC A;  1MVH A;  4AU7 A;  1O9S A;  5JHN A;  3MO2 A;  4RZ0 A;  5CPR B;  4C1Q A;  3MO5 A;  1MVX A;  5T5G A;  3CBO A;  5EG2 A;  3CBP A;  2G46 A;  3F9W A;  3M57 A;  3MEK A;  3TG5 A;  3QWP A;  4H12 A;  4IJ8 A;  4YNP A;  5T0K A;  1N6A A;  4J7I A;  2F69 A;  3OPE A;  5CCM A;  3PDN A;  3RJW A;  3QWV A;  3VV0 A;  3RU0 A;  4WUY A;  3M53 A;  3F9Z A;  4NVQ A;  4QEP A;  5F5E A;  3OXF A;  1MUF A;  5AYF A;  3F9Y A;  3BO5 A;  3S8P A;  5F6L A;  5EX3 A;  5ARF A;  4J83 A;  3RAY A;  3S7F A;  1ZKK A;  2W5Z A;  3M56 A;  3TG4 A;  4I51 A;  1N3J A;  5TH7 A;  2IGQ A;  1MT6 A;  3KMJ A;  3KMA A;  4E47 A;  4IJD A;  3N71 A;  2O8J A;  3QWW A;  5HQ8 A;  2RFI A;  5CCL A;  3M58 A;  4LDG A;  4QEN A;  5KJN A;  2QPW A;  4FMU A;  4JDS A;  3OS5 A;  4J7F A;  3HNA A;  4O30 A;  5JIN A;  5LSX A;  2JV0 A;  1N6C A;  3OXG A;  3M55 A;  3EP0 A;  1ML9 A;  3K5K A;  5F6K C;  5JJ0 A;  5ARG A;  3S7D A;  3DAL A;  4YPU A;  5KJM A;  3RQ4 A;  5KJK A; 
#chains in the Genus database with same CATH topology
 3M5A A;  4YND A;  3RIB A;  3VUZ A;  4BUP A;  4J8O A;  4JLG A;  3M54 A;  1PEG A;  4NJ5 A;  1H3I A;  3FPD A;  4MI5 A;  4Z4P A;  4YNM A;  2BQZ A;  5TTF A;  3M59 A;  3S7B A;  3OOI A;  3CBM A;  5LSZ A;  4YPE A;  2W5Y A;  3KMT A;  3S7J A;  5T0M A;  4MI0 A;  3MO0 A;  3F9X A;  5JIY A;  5EX0 A;  5TEG A;  5F59 A;  3OXL A;  4QEO A;  3IHX A;  3SW9 A;  5HI7 A;  5KJL A;  2R3A A;  4O6F A;  4YPA A;  1XQH A;  3DB5 A;  3SWC A;  1MVH A;  4AU7 A;  1O9S A;  5JHN A;  3MO2 A;  4RZ0 A;  5CPR B;  4C1Q A;  3MO5 A;  1MVX A;  5T5G A;  3CBO A;  5EG2 A;  3CBP A;  2G46 A;  3F9W A;  3M57 A;  3MEK A;  3TG5 A;  3QWP A;  4H12 A;  4IJ8 A;  4YNP A;  5T0K A;  1N6A A;  4J7I A;  2F69 A;  3OPE A;  5CCM A;  3PDN A;  3RJW A;  3QWV A;  3VV0 A;  3RU0 A;  4WUY A;  3M53 A;  3F9Z A;  4NVQ A;  4QEP A;  5F5E A;  3OXF A;  1MUF A;  5AYF A;  3F9Y A;  3BO5 A;  3S8P A;  5F6L A;  5EX3 A;  5ARF A;  4J83 A;  3RAY A;  3S7F A;  1ZKK A;  2W5Z A;  3M56 A;  3TG4 A;  4I51 A;  1N3J A;  5TH7 A;  2IGQ A;  1MT6 A;  3KMJ A;  3KMA A;  4E47 A;  4IJD A;  3N71 A;  2O8J A;  3QWW A;  5HQ8 A;  2RFI A;  5CCL A;  3M58 A;  4LDG A;  4QEN A;  5KJN A;  2QPW A;  4FMU A;  4JDS A;  3OS5 A;  4J7F A;  3HNA A;  4O30 A;  5JIN A;  5LSX A;  2JV0 A;  1N6C A;  3OXG A;  3M55 A;  3EP0 A;  1ML9 A;  3K5K A;  5F6K C;  5JJ0 A;  5ARG A;  3S7D A;  3DAL A;  4YPU A;  5KJM A;  3RQ4 A;  5KJK A; 
#chains in the Genus database with same CATH homology
 3M5A A;  4YND A;  3RIB A;  3VUZ A;  4BUP A;  4J8O A;  4JLG A;  3M54 A;  1PEG A;  4NJ5 A;  1H3I A;  3FPD A;  4MI5 A;  4Z4P A;  4YNM A;  2BQZ A;  5TTF A;  3M59 A;  3S7B A;  3OOI A;  3CBM A;  5LSZ A;  4YPE A;  2W5Y A;  3KMT A;  3S7J A;  5T0M A;  4MI0 A;  3MO0 A;  3F9X A;  5JIY A;  5EX0 A;  5TEG A;  5F59 A;  3OXL A;  4QEO A;  3IHX A;  3SW9 A;  5HI7 A;  5KJL A;  2R3A A;  4O6F A;  4YPA A;  1XQH A;  3DB5 A;  3SWC A;  1MVH A;  4AU7 A;  1O9S A;  5JHN A;  3MO2 A;  4RZ0 A;  5CPR B;  4C1Q A;  3MO5 A;  1MVX A;  5T5G A;  3CBO A;  5EG2 A;  3CBP A;  2G46 A;  3F9W A;  3M57 A;  3MEK A;  3TG5 A;  3QWP A;  4H12 A;  4IJ8 A;  4YNP A;  5T0K A;  1N6A A;  4J7I A;  2F69 A;  3OPE A;  5CCM A;  3PDN A;  3RJW A;  3QWV A;  3VV0 A;  3RU0 A;  4WUY A;  3M53 A;  3F9Z A;  4NVQ A;  4QEP A;  5F5E A;  3OXF A;  1MUF A;  5AYF A;  3F9Y A;  3BO5 A;  3S8P A;  5F6L A;  5EX3 A;  5ARF A;  4J83 A;  3RAY A;  3S7F A;  1ZKK A;  2W5Z A;  3M56 A;  3TG4 A;  4I51 A;  1N3J A;  5TH7 A;  2IGQ A;  1MT6 A;  3KMJ A;  3KMA A;  4E47 A;  4IJD A;  3N71 A;  2O8J A;  3QWW A;  5HQ8 A;  2RFI A;  5CCL A;  3M58 A;  4LDG A;  4QEN A;  5KJN A;  2QPW A;  4FMU A;  4JDS A;  3OS5 A;  4J7F A;  3HNA A;  4O30 A;  5JIN A;  5LSX A;  2JV0 A;  1N6C A;  3OXG A;  3M55 A;  3EP0 A;  1ML9 A;  3K5K A;  5F6K C;  5JJ0 A;  5ARG A;  3S7D A;  3DAL A;  4YPU A;  5KJM A;  3RQ4 A;  5KJK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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