1PEGA

Structural basis for the product specificity of histone lysine methyltransferases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
293
structure length
266
Chain Sequence
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNCLCGTAKCRGYLW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords histone H3 methyltransferase DIM-5
publication title Structural basis for the product specificity of histone lysine methyltransferases
pubmed doi rcsb
source organism Neurospora crassa
molecule tags Transferase
total genus 44
structure length 266
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1pegA00
5LSZA 4QEPA 3QWVA 2IGQA 3S7DA 3KMJA 3FPDA 3F9XA 5KJKA 3MEKA 1ZKKA 4MI0A 5TEGA 3VV0A 3M56A 4AU7A 3CBOA 4RZ0A 1MVXA 4J7FA 3F9ZA 3M54A 5F6KC 4C1QA 3RU0A 3CBPA 3DB5A 3OXFA 5JIYA 5EX0A 5TTFA 3M58A 3MO0A 4IJDA 1N6CA 4H12A 3BO5A 5T0MA 3M5AA 4NVQA 2BQZA 3DALA 3SWCA 4YPEA 4QENA 4YPAA 3OOIA 1MVHA 5CCLA 3M53A 3OPEA 4YNPA 4LDGA 4E47A 3OS5A 4WUYA 5KJLA 3IHXA 4JDSA 3M59A 2F69A 3S8PA 3KMTA 3RJWA 4IJ8A 2W5YA 3MO2A 3RIBA 4JLGA 1N3JA 3RQ4A 1PEGA 3S7JA 5HQ8A 1MUFA 1ML9A 3SW9A 5ARFA 4QEOA 3PDNA 3M55A 5EX3A 2W5ZA 5F5EA 3S7BA 5JINA 3F9WA 5F6LA 3QWWA 5T5GA 3CBMA 4O30A 4J83A 1N6AA 4J8OA 3S7FA 3KMAA 4NJ5A 1O9SA 5CCMA 2G46A 5KJMA 4YPUA 3M57A 1MT6A 5ARGA 3F9YA 2JV0A 3RAYA 3QWPA 4J7IA 3EP0A 5T0KA 5HI7A 5TH7A 4Z4PA 3OXGA 1H3IA 3VUZA 3MO5A 4YNMA 5JJ0A 4YNDA 5EG2A 4FMUA 5LSXA 3OXLA 4O6FA 5KJNA 3TG5A 3N71A 5AYFA 3TG4A 2R3AA 3K5KA 1XQHA 4I51A 2O8JA 2RFIA 3HNAA 5F59A 4BUPA 4MI5A 2QPWA 5CPRB 5JHNA
chains in the Genus database with same CATH superfamily
5LSZA 4QEPA 3QWVA 2IGQA 3S7DA 3KMJA 3FPDA 3F9XA 5KJKA 3MEKA 1ZKKA 4MI0A 5TEGA 3VV0A 3M56A 4AU7A 3CBOA 4RZ0A 1MVXA 4J7FA 3F9ZA 3M54A 5F6KC 4C1QA 3RU0A 3CBPA 3DB5A 3OXFA 5JIYA 5EX0A 5TTFA 3M58A 3MO0A 4IJDA 1N6CA 4H12A 3BO5A 5T0MA 3M5AA 4NVQA 2BQZA 3DALA 3SWCA 4YPEA 4QENA 4YPAA 3OOIA 1MVHA 5CCLA 3M53A 3OPEA 4YNPA 4LDGA 4E47A 3OS5A 4WUYA 5KJLA 3IHXA 4JDSA 3M59A 2F69A 3S8PA 3KMTA 3RJWA 4IJ8A 2W5YA 3MO2A 3RIBA 4JLGA 1N3JA 3RQ4A 1PEGA 3S7JA 5HQ8A 1MUFA 1ML9A 3SW9A 5ARFA 4QEOA 3PDNA 3M55A 5EX3A 2W5ZA 5F5EA 3S7BA 5JINA 3F9WA 5F6LA 3QWWA 5T5GA 3CBMA 4O30A 4J83A 1N6AA 4J8OA 3S7FA 3KMAA 4NJ5A 1O9SA 5CCMA 2G46A 5KJMA 4YPUA 3M57A 1MT6A 5ARGA 3F9YA 2JV0A 3RAYA 3QWPA 4J7IA 3EP0A 5T0KA 5HI7A 5TH7A 4Z4PA 3OXGA 1H3IA 3VUZA 3MO5A 4YNMA 5JJ0A 4YNDA 5EG2A 4FMUA 5LSXA 3OXLA 4O6FA 5KJNA 3TG5A 3N71A 5AYFA 3TG4A 2R3AA 3K5KA 1XQHA 4I51A 2O8JA 2RFIA 3HNAA 5F59A 4BUPA 4MI5A 2QPWA 5CPRB 5JHNA
chains in the Genus database with same CATH topology
5LSZA 4QEPA 3QWVA 2IGQA 3S7DA 3KMJA 3FPDA 3F9XA 5KJKA 3MEKA 1ZKKA 4MI0A 5TEGA 3VV0A 3M56A 4AU7A 3CBOA 4RZ0A 1MVXA 4J7FA 3F9ZA 3M54A 5F6KC 4C1QA 3RU0A 3CBPA 3DB5A 3OXFA 5JIYA 5EX0A 5TTFA 3M58A 3MO0A 4IJDA 1N6CA 4H12A 3BO5A 5T0MA 3M5AA 4NVQA 2BQZA 3DALA 3SWCA 4YPEA 4QENA 4YPAA 3OOIA 1MVHA 5CCLA 3M53A 3OPEA 4YNPA 4LDGA 4E47A 3OS5A 4WUYA 5KJLA 3IHXA 4JDSA 3M59A 2F69A 3S8PA 3KMTA 3RJWA 4IJ8A 2W5YA 3MO2A 3RIBA 4JLGA 1N3JA 3RQ4A 1PEGA 3S7JA 5HQ8A 1MUFA 1ML9A 3SW9A 5ARFA 4QEOA 3PDNA 3M55A 5EX3A 2W5ZA 5F5EA 3S7BA 5JINA 3F9WA 5F6LA 3QWWA 5T5GA 3CBMA 4O30A 4J83A 1N6AA 4J8OA 3S7FA 3KMAA 4NJ5A 1O9SA 5CCMA 2G46A 5KJMA 4YPUA 3M57A 1MT6A 5ARGA 3F9YA 2JV0A 3RAYA 3QWPA 4J7IA 3EP0A 5T0KA 5HI7A 5TH7A 4Z4PA 3OXGA 1H3IA 3VUZA 3MO5A 4YNMA 5JJ0A 4YNDA 5EG2A 4FMUA 5LSXA 3OXLA 4O6FA 5KJNA 3TG5A 3N71A 5AYFA 3TG4A 2R3AA 3K5KA 1XQHA 4I51A 2O8JA 2RFIA 3HNAA 5F59A 4BUPA 4MI5A 2QPWA 5CPRB 5JHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LSZ A;  4QEP A;  3QWV A;  2IGQ A;  3S7D A;  3KMJ A;  3FPD A;  3F9X A;  5KJK A;  3MEK A;  1ZKK A;  4MI0 A;  5TEG A;  3VV0 A;  3M56 A;  4AU7 A;  3CBO A;  4RZ0 A;  1MVX A;  4J7F A;  3F9Z A;  3M54 A;  5F6K C;  4C1Q A;  3RU0 A;  3CBP A;  3DB5 A;  3OXF A;  5JIY A;  5EX0 A;  5TTF A;  3M58 A;  3MO0 A;  4IJD A;  1N6C A;  4H12 A;  3BO5 A;  5T0M A;  3M5A A;  4NVQ A;  2BQZ A;  3DAL A;  3SWC A;  4YPE A;  4QEN A;  4YPA A;  3OOI A;  1MVH A;  5CCL A;  3M53 A;  3OPE A;  4YNP A;  4LDG A;  4E47 A;  3OS5 A;  4WUY A;  5KJL A;  3IHX A;  4JDS A;  3M59 A;  2F69 A;  3S8P A;  3KMT A;  3RJW A;  4IJ8 A;  2W5Y A;  3MO2 A;  3RIB A;  4JLG A;  1N3J A;  3RQ4 A;  1PEG A;  3S7J A;  5HQ8 A;  1MUF A;  1ML9 A;  3SW9 A;  5ARF A;  4QEO A;  3PDN A;  3M55 A;  5EX3 A;  2W5Z A;  5F5E A;  3S7B A;  5JIN A;  3F9W A;  5F6L A;  3QWW A;  5T5G A;  3CBM A;  4O30 A;  4J83 A;  1N6A A;  4J8O A;  3S7F A;  3KMA A;  4NJ5 A;  1O9S A;  5CCM A;  2G46 A;  5KJM A;  4YPU A;  3M57 A;  1MT6 A;  5ARG A;  3F9Y A;  2JV0 A;  3RAY A;  3QWP A;  4J7I A;  3EP0 A;  5T0K A;  5HI7 A;  5TH7 A;  4Z4P A;  3OXG A;  1H3I A;  3VUZ A;  3MO5 A;  4YNM A;  5JJ0 A;  4YND A;  5EG2 A;  4FMU A;  5LSX A;  3OXL A;  4O6F A;  5KJN A;  3TG5 A;  3N71 A;  5AYF A;  3TG4 A;  2R3A A;  3K5K A;  1XQH A;  4I51 A;  2O8J A;  2RFI A;  3HNA A;  5F59 A;  4BUP A;  4MI5 A;  2QPW A;  5CPR B;  5JHN A; 
#chains in the Genus database with same CATH topology
 5LSZ A;  4QEP A;  3QWV A;  2IGQ A;  3S7D A;  3KMJ A;  3FPD A;  3F9X A;  5KJK A;  3MEK A;  1ZKK A;  4MI0 A;  5TEG A;  3VV0 A;  3M56 A;  4AU7 A;  3CBO A;  4RZ0 A;  1MVX A;  4J7F A;  3F9Z A;  3M54 A;  5F6K C;  4C1Q A;  3RU0 A;  3CBP A;  3DB5 A;  3OXF A;  5JIY A;  5EX0 A;  5TTF A;  3M58 A;  3MO0 A;  4IJD A;  1N6C A;  4H12 A;  3BO5 A;  5T0M A;  3M5A A;  4NVQ A;  2BQZ A;  3DAL A;  3SWC A;  4YPE A;  4QEN A;  4YPA A;  3OOI A;  1MVH A;  5CCL A;  3M53 A;  3OPE A;  4YNP A;  4LDG A;  4E47 A;  3OS5 A;  4WUY A;  5KJL A;  3IHX A;  4JDS A;  3M59 A;  2F69 A;  3S8P A;  3KMT A;  3RJW A;  4IJ8 A;  2W5Y A;  3MO2 A;  3RIB A;  4JLG A;  1N3J A;  3RQ4 A;  1PEG A;  3S7J A;  5HQ8 A;  1MUF A;  1ML9 A;  3SW9 A;  5ARF A;  4QEO A;  3PDN A;  3M55 A;  5EX3 A;  2W5Z A;  5F5E A;  3S7B A;  5JIN A;  3F9W A;  5F6L A;  3QWW A;  5T5G A;  3CBM A;  4O30 A;  4J83 A;  1N6A A;  4J8O A;  3S7F A;  3KMA A;  4NJ5 A;  1O9S A;  5CCM A;  2G46 A;  5KJM A;  4YPU A;  3M57 A;  1MT6 A;  5ARG A;  3F9Y A;  2JV0 A;  3RAY A;  3QWP A;  4J7I A;  3EP0 A;  5T0K A;  5HI7 A;  5TH7 A;  4Z4P A;  3OXG A;  1H3I A;  3VUZ A;  3MO5 A;  4YNM A;  5JJ0 A;  4YND A;  5EG2 A;  4FMU A;  5LSX A;  3OXL A;  4O6F A;  5KJN A;  3TG5 A;  3N71 A;  5AYF A;  3TG4 A;  2R3A A;  3K5K A;  1XQH A;  4I51 A;  2O8J A;  2RFI A;  3HNA A;  5F59 A;  4BUP A;  4MI5 A;  2QPW A;  5CPR B;  5JHN A; 
#chains in the Genus database with same CATH homology
 5LSZ A;  4QEP A;  3QWV A;  2IGQ A;  3S7D A;  3KMJ A;  3FPD A;  3F9X A;  5KJK A;  3MEK A;  1ZKK A;  4MI0 A;  5TEG A;  3VV0 A;  3M56 A;  4AU7 A;  3CBO A;  4RZ0 A;  1MVX A;  4J7F A;  3F9Z A;  3M54 A;  5F6K C;  4C1Q A;  3RU0 A;  3CBP A;  3DB5 A;  3OXF A;  5JIY A;  5EX0 A;  5TTF A;  3M58 A;  3MO0 A;  4IJD A;  1N6C A;  4H12 A;  3BO5 A;  5T0M A;  3M5A A;  4NVQ A;  2BQZ A;  3DAL A;  3SWC A;  4YPE A;  4QEN A;  4YPA A;  3OOI A;  1MVH A;  5CCL A;  3M53 A;  3OPE A;  4YNP A;  4LDG A;  4E47 A;  3OS5 A;  4WUY A;  5KJL A;  3IHX A;  4JDS A;  3M59 A;  2F69 A;  3S8P A;  3KMT A;  3RJW A;  4IJ8 A;  2W5Y A;  3MO2 A;  3RIB A;  4JLG A;  1N3J A;  3RQ4 A;  1PEG A;  3S7J A;  5HQ8 A;  1MUF A;  1ML9 A;  3SW9 A;  5ARF A;  4QEO A;  3PDN A;  3M55 A;  5EX3 A;  2W5Z A;  5F5E A;  3S7B A;  5JIN A;  3F9W A;  5F6L A;  3QWW A;  5T5G A;  3CBM A;  4O30 A;  4J83 A;  1N6A A;  4J8O A;  3S7F A;  3KMA A;  4NJ5 A;  1O9S A;  5CCM A;  2G46 A;  5KJM A;  4YPU A;  3M57 A;  1MT6 A;  5ARG A;  3F9Y A;  2JV0 A;  3RAY A;  3QWP A;  4J7I A;  3EP0 A;  5T0K A;  5HI7 A;  5TH7 A;  4Z4P A;  3OXG A;  1H3I A;  3VUZ A;  3MO5 A;  4YNM A;  5JJ0 A;  4YND A;  5EG2 A;  4FMU A;  5LSX A;  3OXL A;  4O6F A;  5KJN A;  3TG5 A;  3N71 A;  5AYF A;  3TG4 A;  2R3A A;  3K5K A;  1XQH A;  4I51 A;  2O8J A;  2RFI A;  3HNA A;  5F59 A;  4BUP A;  4MI5 A;  2QPW A;  5CPR B;  5JHN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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