1PEGA

Structural basis for the product specificity of histone lysine methyltransferases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
293
structure length
266
Chain Sequence
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNCLCGTAKCRGYLW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords histone H3 methyltransferase DIM-5
publication title Structural basis for the product specificity of histone lysine methyltransferases
pubmed doi rcsb
source organism Neurospora crassa
total genus 44
structure length 266
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1pegA00
3SW9A 3EP0A 1XQHA 4QEPA 3KMAA 3RIBA 5EX3A 3S7BA 3F9YA 3F9ZA 5JIYA 3S8PA 4NJ5A 3M5AA 3MO2A 5ARFA 3FPDA 4BUPA 3M53A 4IJDA 4YNDA 4YNMA 1N6CA 3M56A 5KJLA 5F6LA 3DALA 4J83A 3M59A 3CBMA 3MEKA 4E47A 5TTFA 4J7FA 5CPRB 5T5GA 3S7JA 3HNAA 3N71A 3SWCA 2R3AA 3K5KA 5F5EA 4J8OA 5F6KC 4LDGA 1ZKKA 2G46A 2QPWA 3OXGA 4YNPA 4AU7A 3RAYA 3M57A 5HQ8A 4WUYA 3F9XA 1ML9A 4Z4PA 3VV0A 3M58A 3VUZA 3S7FA 3OXFA 2W5ZA 1MVXA 3BO5A 3CBOA 5KJMA 2O8JA 1PEGA 5F59A 3OS5A 2IGQA 1O9SA 1N3JA 1MVHA 3RQ4A 3MO0A 5T0MA 5JJ0A 4I51A 4J7IA 3KMJA 5LSXA 5ARGA 5T0KA 4O30A 3OPEA 5EX0A 2JV0A 3RJWA 4JDSA 5AYFA 4QEOA 3TG5A 1H3IA 4MI5A 1N6AA 3RU0A 5EG2A 5TEGA 3TG4A 3OXLA 5CCLA 2BQZA 2F69A 3QWVA 4NVQA 5KJNA 1MUFA 5TH7A 4FMUA 3IHXA 4YPAA 5KJKA 4QENA 3DB5A 3MO5A 5LSZA 3S7DA 2RFIA 4YPEA 3M54A 3PDNA 4RZ0A 5JINA 4O6FA 4H12A 4JLGA 3KMTA 4C1QA 3QWPA 3OOIA 2W5YA 4YPUA 5JHNA 3M55A 5CCMA 3F9WA 3CBPA 5HI7A 1MT6A 4IJ8A 4MI0A 3QWWA
chains in the Genus database with same CATH superfamily
3SW9A 3EP0A 1XQHA 4QEPA 3KMAA 3RIBA 5EX3A 3S7BA 3F9YA 3F9ZA 5JIYA 3S8PA 4NJ5A 3M5AA 3MO2A 5ARFA 3FPDA 4BUPA 3M53A 4IJDA 4YNDA 4YNMA 1N6CA 3M56A 5KJLA 5F6LA 3DALA 4J83A 3M59A 3CBMA 3MEKA 4E47A 5TTFA 4J7FA 5CPRB 5T5GA 3S7JA 3HNAA 3N71A 3SWCA 2R3AA 3K5KA 5F5EA 4J8OA 5F6KC 4LDGA 1ZKKA 2G46A 2QPWA 3OXGA 4YNPA 4AU7A 3RAYA 3M57A 5HQ8A 4WUYA 3F9XA 1ML9A 4Z4PA 3VV0A 3M58A 3VUZA 3S7FA 3OXFA 2W5ZA 1MVXA 3BO5A 3CBOA 5KJMA 2O8JA 1PEGA 5F59A 3OS5A 2IGQA 1O9SA 1N3JA 1MVHA 3RQ4A 3MO0A 5T0MA 5JJ0A 4I51A 4J7IA 3KMJA 5LSXA 5ARGA 5T0KA 4O30A 3OPEA 5EX0A 2JV0A 3RJWA 4JDSA 5AYFA 4QEOA 3TG5A 1H3IA 4MI5A 1N6AA 3RU0A 5EG2A 5TEGA 3TG4A 3OXLA 5CCLA 2BQZA 2F69A 3QWVA 4NVQA 5KJNA 1MUFA 5TH7A 4FMUA 3IHXA 4YPAA 5KJKA 4QENA 3DB5A 3MO5A 5LSZA 3S7DA 2RFIA 4YPEA 3M54A 3PDNA 4RZ0A 5JINA 4O6FA 4H12A 4JLGA 3KMTA 4C1QA 3QWPA 3OOIA 2W5YA 4YPUA 5JHNA 3M55A 5CCMA 3F9WA 3CBPA 5HI7A 1MT6A 4IJ8A 4MI0A 3QWWA
chains in the Genus database with same CATH topology
3SW9A 3EP0A 1XQHA 4QEPA 3KMAA 3RIBA 5EX3A 3S7BA 3F9YA 3F9ZA 5JIYA 3S8PA 4NJ5A 3M5AA 3MO2A 5ARFA 3FPDA 4BUPA 3M53A 4IJDA 4YNDA 4YNMA 1N6CA 3M56A 5KJLA 5F6LA 3DALA 4J83A 3M59A 3CBMA 3MEKA 4E47A 5TTFA 4J7FA 5CPRB 5T5GA 3S7JA 3HNAA 3N71A 3SWCA 2R3AA 3K5KA 5F5EA 4J8OA 5F6KC 4LDGA 1ZKKA 2G46A 2QPWA 3OXGA 4YNPA 4AU7A 3RAYA 3M57A 5HQ8A 4WUYA 3F9XA 1ML9A 4Z4PA 3VV0A 3M58A 3VUZA 3S7FA 3OXFA 2W5ZA 1MVXA 3BO5A 3CBOA 5KJMA 2O8JA 1PEGA 5F59A 3OS5A 2IGQA 1O9SA 1N3JA 1MVHA 3RQ4A 3MO0A 5T0MA 5JJ0A 4I51A 4J7IA 3KMJA 5LSXA 5ARGA 5T0KA 4O30A 3OPEA 5EX0A 2JV0A 3RJWA 4JDSA 5AYFA 4QEOA 3TG5A 1H3IA 4MI5A 1N6AA 3RU0A 5EG2A 5TEGA 3TG4A 3OXLA 5CCLA 2BQZA 2F69A 3QWVA 4NVQA 5KJNA 1MUFA 5TH7A 4FMUA 3IHXA 4YPAA 5KJKA 4QENA 3DB5A 3MO5A 5LSZA 3S7DA 2RFIA 4YPEA 3M54A 3PDNA 4RZ0A 5JINA 4O6FA 4H12A 4JLGA 3KMTA 4C1QA 3QWPA 3OOIA 2W5YA 4YPUA 5JHNA 3M55A 5CCMA 3F9WA 3CBPA 5HI7A 1MT6A 4IJ8A 4MI0A 3QWWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SW9 A;  3EP0 A;  1XQH A;  4QEP A;  3KMA A;  3RIB A;  5EX3 A;  3S7B A;  3F9Y A;  3F9Z A;  5JIY A;  3S8P A;  4NJ5 A;  3M5A A;  3MO2 A;  5ARF A;  3FPD A;  4BUP A;  3M53 A;  4IJD A;  4YND A;  4YNM A;  1N6C A;  3M56 A;  5KJL A;  5F6L A;  3DAL A;  4J83 A;  3M59 A;  3CBM A;  3MEK A;  4E47 A;  5TTF A;  4J7F A;  5CPR B;  5T5G A;  3S7J A;  3HNA A;  3N71 A;  3SWC A;  2R3A A;  3K5K A;  5F5E A;  4J8O A;  5F6K C;  4LDG A;  1ZKK A;  2G46 A;  2QPW A;  3OXG A;  4YNP A;  4AU7 A;  3RAY A;  3M57 A;  5HQ8 A;  4WUY A;  3F9X A;  1ML9 A;  4Z4P A;  3VV0 A;  3M58 A;  3VUZ A;  3S7F A;  3OXF A;  2W5Z A;  1MVX A;  3BO5 A;  3CBO A;  5KJM A;  2O8J A;  1PEG A;  5F59 A;  3OS5 A;  2IGQ A;  1O9S A;  1N3J A;  1MVH A;  3RQ4 A;  3MO0 A;  5T0M A;  5JJ0 A;  4I51 A;  4J7I A;  3KMJ A;  5LSX A;  5ARG A;  5T0K A;  4O30 A;  3OPE A;  5EX0 A;  2JV0 A;  3RJW A;  4JDS A;  5AYF A;  4QEO A;  3TG5 A;  1H3I A;  4MI5 A;  1N6A A;  3RU0 A;  5EG2 A;  5TEG A;  3TG4 A;  3OXL A;  5CCL A;  2BQZ A;  2F69 A;  3QWV A;  4NVQ A;  5KJN A;  1MUF A;  5TH7 A;  4FMU A;  3IHX A;  4YPA A;  5KJK A;  4QEN A;  3DB5 A;  3MO5 A;  5LSZ A;  3S7D A;  2RFI A;  4YPE A;  3M54 A;  3PDN A;  4RZ0 A;  5JIN A;  4O6F A;  4H12 A;  4JLG A;  3KMT A;  4C1Q A;  3QWP A;  3OOI A;  2W5Y A;  4YPU A;  5JHN A;  3M55 A;  5CCM A;  3F9W A;  3CBP A;  5HI7 A;  1MT6 A;  4IJ8 A;  4MI0 A;  3QWW A; 
#chains in the Genus database with same CATH topology
 3SW9 A;  3EP0 A;  1XQH A;  4QEP A;  3KMA A;  3RIB A;  5EX3 A;  3S7B A;  3F9Y A;  3F9Z A;  5JIY A;  3S8P A;  4NJ5 A;  3M5A A;  3MO2 A;  5ARF A;  3FPD A;  4BUP A;  3M53 A;  4IJD A;  4YND A;  4YNM A;  1N6C A;  3M56 A;  5KJL A;  5F6L A;  3DAL A;  4J83 A;  3M59 A;  3CBM A;  3MEK A;  4E47 A;  5TTF A;  4J7F A;  5CPR B;  5T5G A;  3S7J A;  3HNA A;  3N71 A;  3SWC A;  2R3A A;  3K5K A;  5F5E A;  4J8O A;  5F6K C;  4LDG A;  1ZKK A;  2G46 A;  2QPW A;  3OXG A;  4YNP A;  4AU7 A;  3RAY A;  3M57 A;  5HQ8 A;  4WUY A;  3F9X A;  1ML9 A;  4Z4P A;  3VV0 A;  3M58 A;  3VUZ A;  3S7F A;  3OXF A;  2W5Z A;  1MVX A;  3BO5 A;  3CBO A;  5KJM A;  2O8J A;  1PEG A;  5F59 A;  3OS5 A;  2IGQ A;  1O9S A;  1N3J A;  1MVH A;  3RQ4 A;  3MO0 A;  5T0M A;  5JJ0 A;  4I51 A;  4J7I A;  3KMJ A;  5LSX A;  5ARG A;  5T0K A;  4O30 A;  3OPE A;  5EX0 A;  2JV0 A;  3RJW A;  4JDS A;  5AYF A;  4QEO A;  3TG5 A;  1H3I A;  4MI5 A;  1N6A A;  3RU0 A;  5EG2 A;  5TEG A;  3TG4 A;  3OXL A;  5CCL A;  2BQZ A;  2F69 A;  3QWV A;  4NVQ A;  5KJN A;  1MUF A;  5TH7 A;  4FMU A;  3IHX A;  4YPA A;  5KJK A;  4QEN A;  3DB5 A;  3MO5 A;  5LSZ A;  3S7D A;  2RFI A;  4YPE A;  3M54 A;  3PDN A;  4RZ0 A;  5JIN A;  4O6F A;  4H12 A;  4JLG A;  3KMT A;  4C1Q A;  3QWP A;  3OOI A;  2W5Y A;  4YPU A;  5JHN A;  3M55 A;  5CCM A;  3F9W A;  3CBP A;  5HI7 A;  1MT6 A;  4IJ8 A;  4MI0 A;  3QWW A; 
#chains in the Genus database with same CATH homology
 3SW9 A;  3EP0 A;  1XQH A;  4QEP A;  3KMA A;  3RIB A;  5EX3 A;  3S7B A;  3F9Y A;  3F9Z A;  5JIY A;  3S8P A;  4NJ5 A;  3M5A A;  3MO2 A;  5ARF A;  3FPD A;  4BUP A;  3M53 A;  4IJD A;  4YND A;  4YNM A;  1N6C A;  3M56 A;  5KJL A;  5F6L A;  3DAL A;  4J83 A;  3M59 A;  3CBM A;  3MEK A;  4E47 A;  5TTF A;  4J7F A;  5CPR B;  5T5G A;  3S7J A;  3HNA A;  3N71 A;  3SWC A;  2R3A A;  3K5K A;  5F5E A;  4J8O A;  5F6K C;  4LDG A;  1ZKK A;  2G46 A;  2QPW A;  3OXG A;  4YNP A;  4AU7 A;  3RAY A;  3M57 A;  5HQ8 A;  4WUY A;  3F9X A;  1ML9 A;  4Z4P A;  3VV0 A;  3M58 A;  3VUZ A;  3S7F A;  3OXF A;  2W5Z A;  1MVX A;  3BO5 A;  3CBO A;  5KJM A;  2O8J A;  1PEG A;  5F59 A;  3OS5 A;  2IGQ A;  1O9S A;  1N3J A;  1MVH A;  3RQ4 A;  3MO0 A;  5T0M A;  5JJ0 A;  4I51 A;  4J7I A;  3KMJ A;  5LSX A;  5ARG A;  5T0K A;  4O30 A;  3OPE A;  5EX0 A;  2JV0 A;  3RJW A;  4JDS A;  5AYF A;  4QEO A;  3TG5 A;  1H3I A;  4MI5 A;  1N6A A;  3RU0 A;  5EG2 A;  5TEG A;  3TG4 A;  3OXL A;  5CCL A;  2BQZ A;  2F69 A;  3QWV A;  4NVQ A;  5KJN A;  1MUF A;  5TH7 A;  4FMU A;  3IHX A;  4YPA A;  5KJK A;  4QEN A;  3DB5 A;  3MO5 A;  5LSZ A;  3S7D A;  2RFI A;  4YPE A;  3M54 A;  3PDN A;  4RZ0 A;  5JIN A;  4O6F A;  4H12 A;  4JLG A;  3KMT A;  4C1Q A;  3QWP A;  3OOI A;  2W5Y A;  4YPU A;  5JHN A;  3M55 A;  5CCM A;  3F9W A;  3CBP A;  5HI7 A;  1MT6 A;  4IJ8 A;  4MI0 A;  3QWW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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