1PEGA

Structural basis for the product specificity of histone lysine methyltransferases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
293
structure length
266
Chain Sequence
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNCLCGTAKCRGYLW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords histone H3 methyltransferase DIM-5
publication title Structural basis for the product specificity of histone lysine methyltransferases
pubmed doi rcsb
source organism Neurospora crassa
molecule tags Transferase
total genus 44
structure length 266
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1pegA00
3M54A 3RIBA 1N6AA 4J7IA 4BUPA 3S7FA 5T5GA 1N6CA 4LDGA 3M59A 5EG2A 4IJDA 3RJWA 5F6KC 4MI5A 3M55A 4J7FA 2R3AA 4NJ5A 5AYFA 3M56A 3OXFA 5CPRB 2G46A 1ML9A 3EP0A 4O30A 3F9XA 3F9YA 4FMUA 5F5EA 4C1QA 4QENA 3MO2A 3M58A 3OOIA 3SW9A 4O6FA 3F9WA 3OXLA 3RQ4A 5F6LA 5KJNA 3QWWA 5TH7A 1H3IA 4H12A 3SWCA 3K5KA 4QEPA 3HNAA 3IHXA 5JIYA 3DALA 3M57A 5HI7A 3PDNA 4YNMA 3TG4A 1MVHA 5EX3A 4YNPA 1MUFA 4J8OA 5TEGA 5JJ0A 5T0MA 3RU0A 5JINA 1XQHA 3N71A 3RAYA 1O9SA 4YPEA 5ARGA 3CBPA 4QEOA 4J83A 2JV0A 2QPWA 2F69A 2RFIA 3QWPA 3VV0A 4JDSA 2IGQA 1ZKKA 3S8PA 4E47A 5JHNA 4IJ8A 5EX0A 5LSXA 3S7JA 5KJMA 5CCMA 3KMTA 3MEKA 3FPDA 3KMJA 3OS5A 5ARFA 4YPUA 3KMAA 4RZ0A 3M5AA 2W5ZA 3OXGA 3OPEA 4YPAA 3TG5A 3QWVA 3CBOA 1PEGA 3S7BA 4JLGA 4Z4PA 3MO0A 3CBMA 4YNDA 3VUZA 5HQ8A 3F9ZA 4MI0A 5KJKA 5F59A 1MVXA 5TTFA 5CCLA 5KJLA 4WUYA 4I51A 1MT6A 3S7DA 2BQZA 3BO5A 5T0KA 3DB5A 4NVQA 5LSZA 2O8JA 3M53A 3MO5A 4AU7A 1N3JA 2W5YA
chains in the Genus database with same CATH superfamily
3M54A 3RIBA 1N6AA 4J7IA 4BUPA 3S7FA 5T5GA 1N6CA 4LDGA 3M59A 5EG2A 4IJDA 3RJWA 5F6KC 4MI5A 3M55A 4J7FA 2R3AA 4NJ5A 5AYFA 3M56A 3OXFA 5CPRB 2G46A 1ML9A 3EP0A 4O30A 3F9XA 3F9YA 4FMUA 5F5EA 4C1QA 4QENA 3MO2A 3M58A 3OOIA 3SW9A 4O6FA 3F9WA 3OXLA 3RQ4A 5F6LA 5KJNA 3QWWA 5TH7A 1H3IA 4H12A 3SWCA 3K5KA 4QEPA 3HNAA 3IHXA 5JIYA 3DALA 3M57A 5HI7A 3PDNA 4YNMA 3TG4A 1MVHA 5EX3A 4YNPA 1MUFA 4J8OA 5TEGA 5JJ0A 5T0MA 3RU0A 5JINA 1XQHA 3N71A 3RAYA 1O9SA 4YPEA 5ARGA 3CBPA 4QEOA 4J83A 2JV0A 2QPWA 2F69A 2RFIA 3QWPA 3VV0A 4JDSA 2IGQA 1ZKKA 3S8PA 4E47A 5JHNA 4IJ8A 5EX0A 5LSXA 3S7JA 5KJMA 5CCMA 3KMTA 3MEKA 3FPDA 3KMJA 3OS5A 5ARFA 4YPUA 3KMAA 4RZ0A 3M5AA 2W5ZA 3OXGA 3OPEA 4YPAA 3TG5A 3QWVA 3CBOA 1PEGA 3S7BA 4JLGA 4Z4PA 3MO0A 3CBMA 4YNDA 3VUZA 5HQ8A 3F9ZA 4MI0A 5KJKA 5F59A 1MVXA 5TTFA 5CCLA 5KJLA 4WUYA 4I51A 1MT6A 3S7DA 2BQZA 3BO5A 5T0KA 3DB5A 4NVQA 5LSZA 2O8JA 3M53A 3MO5A 4AU7A 1N3JA 2W5YA
chains in the Genus database with same CATH topology
3M54A 3RIBA 1N6AA 4J7IA 4BUPA 3S7FA 5T5GA 1N6CA 4LDGA 3M59A 5EG2A 4IJDA 3RJWA 5F6KC 4MI5A 3M55A 4J7FA 2R3AA 4NJ5A 5AYFA 3M56A 3OXFA 5CPRB 2G46A 1ML9A 3EP0A 4O30A 3F9XA 3F9YA 4FMUA 5F5EA 4C1QA 4QENA 3MO2A 3M58A 3OOIA 3SW9A 4O6FA 3F9WA 3OXLA 3RQ4A 5F6LA 5KJNA 3QWWA 5TH7A 1H3IA 4H12A 3SWCA 3K5KA 4QEPA 3HNAA 3IHXA 5JIYA 3DALA 3M57A 5HI7A 3PDNA 4YNMA 3TG4A 1MVHA 5EX3A 4YNPA 1MUFA 4J8OA 5TEGA 5JJ0A 5T0MA 3RU0A 5JINA 1XQHA 3N71A 3RAYA 1O9SA 4YPEA 5ARGA 3CBPA 4QEOA 4J83A 2JV0A 2QPWA 2F69A 2RFIA 3QWPA 3VV0A 4JDSA 2IGQA 1ZKKA 3S8PA 4E47A 5JHNA 4IJ8A 5EX0A 5LSXA 3S7JA 5KJMA 5CCMA 3KMTA 3MEKA 3FPDA 3KMJA 3OS5A 5ARFA 4YPUA 3KMAA 4RZ0A 3M5AA 2W5ZA 3OXGA 3OPEA 4YPAA 3TG5A 3QWVA 3CBOA 1PEGA 3S7BA 4JLGA 4Z4PA 3MO0A 3CBMA 4YNDA 3VUZA 5HQ8A 3F9ZA 4MI0A 5KJKA 5F59A 1MVXA 5TTFA 5CCLA 5KJLA 4WUYA 4I51A 1MT6A 3S7DA 2BQZA 3BO5A 5T0KA 3DB5A 4NVQA 5LSZA 2O8JA 3M53A 3MO5A 4AU7A 1N3JA 2W5YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M54 A;  3RIB A;  1N6A A;  4J7I A;  4BUP A;  3S7F A;  5T5G A;  1N6C A;  4LDG A;  3M59 A;  5EG2 A;  4IJD A;  3RJW A;  5F6K C;  4MI5 A;  3M55 A;  4J7F A;  2R3A A;  4NJ5 A;  5AYF A;  3M56 A;  3OXF A;  5CPR B;  2G46 A;  1ML9 A;  3EP0 A;  4O30 A;  3F9X A;  3F9Y A;  4FMU A;  5F5E A;  4C1Q A;  4QEN A;  3MO2 A;  3M58 A;  3OOI A;  3SW9 A;  4O6F A;  3F9W A;  3OXL A;  3RQ4 A;  5F6L A;  5KJN A;  3QWW A;  5TH7 A;  1H3I A;  4H12 A;  3SWC A;  3K5K A;  4QEP A;  3HNA A;  3IHX A;  5JIY A;  3DAL A;  3M57 A;  5HI7 A;  3PDN A;  4YNM A;  3TG4 A;  1MVH A;  5EX3 A;  4YNP A;  1MUF A;  4J8O A;  5TEG A;  5JJ0 A;  5T0M A;  3RU0 A;  5JIN A;  1XQH A;  3N71 A;  3RAY A;  1O9S A;  4YPE A;  5ARG A;  3CBP A;  4QEO A;  4J83 A;  2JV0 A;  2QPW A;  2F69 A;  2RFI A;  3QWP A;  3VV0 A;  4JDS A;  2IGQ A;  1ZKK A;  3S8P A;  4E47 A;  5JHN A;  4IJ8 A;  5EX0 A;  5LSX A;  3S7J A;  5KJM A;  5CCM A;  3KMT A;  3MEK A;  3FPD A;  3KMJ A;  3OS5 A;  5ARF A;  4YPU A;  3KMA A;  4RZ0 A;  3M5A A;  2W5Z A;  3OXG A;  3OPE A;  4YPA A;  3TG5 A;  3QWV A;  3CBO A;  1PEG A;  3S7B A;  4JLG A;  4Z4P A;  3MO0 A;  3CBM A;  4YND A;  3VUZ A;  5HQ8 A;  3F9Z A;  4MI0 A;  5KJK A;  5F59 A;  1MVX A;  5TTF A;  5CCL A;  5KJL A;  4WUY A;  4I51 A;  1MT6 A;  3S7D A;  2BQZ A;  3BO5 A;  5T0K A;  3DB5 A;  4NVQ A;  5LSZ A;  2O8J A;  3M53 A;  3MO5 A;  4AU7 A;  1N3J A;  2W5Y A; 
#chains in the Genus database with same CATH topology
 3M54 A;  3RIB A;  1N6A A;  4J7I A;  4BUP A;  3S7F A;  5T5G A;  1N6C A;  4LDG A;  3M59 A;  5EG2 A;  4IJD A;  3RJW A;  5F6K C;  4MI5 A;  3M55 A;  4J7F A;  2R3A A;  4NJ5 A;  5AYF A;  3M56 A;  3OXF A;  5CPR B;  2G46 A;  1ML9 A;  3EP0 A;  4O30 A;  3F9X A;  3F9Y A;  4FMU A;  5F5E A;  4C1Q A;  4QEN A;  3MO2 A;  3M58 A;  3OOI A;  3SW9 A;  4O6F A;  3F9W A;  3OXL A;  3RQ4 A;  5F6L A;  5KJN A;  3QWW A;  5TH7 A;  1H3I A;  4H12 A;  3SWC A;  3K5K A;  4QEP A;  3HNA A;  3IHX A;  5JIY A;  3DAL A;  3M57 A;  5HI7 A;  3PDN A;  4YNM A;  3TG4 A;  1MVH A;  5EX3 A;  4YNP A;  1MUF A;  4J8O A;  5TEG A;  5JJ0 A;  5T0M A;  3RU0 A;  5JIN A;  1XQH A;  3N71 A;  3RAY A;  1O9S A;  4YPE A;  5ARG A;  3CBP A;  4QEO A;  4J83 A;  2JV0 A;  2QPW A;  2F69 A;  2RFI A;  3QWP A;  3VV0 A;  4JDS A;  2IGQ A;  1ZKK A;  3S8P A;  4E47 A;  5JHN A;  4IJ8 A;  5EX0 A;  5LSX A;  3S7J A;  5KJM A;  5CCM A;  3KMT A;  3MEK A;  3FPD A;  3KMJ A;  3OS5 A;  5ARF A;  4YPU A;  3KMA A;  4RZ0 A;  3M5A A;  2W5Z A;  3OXG A;  3OPE A;  4YPA A;  3TG5 A;  3QWV A;  3CBO A;  1PEG A;  3S7B A;  4JLG A;  4Z4P A;  3MO0 A;  3CBM A;  4YND A;  3VUZ A;  5HQ8 A;  3F9Z A;  4MI0 A;  5KJK A;  5F59 A;  1MVX A;  5TTF A;  5CCL A;  5KJL A;  4WUY A;  4I51 A;  1MT6 A;  3S7D A;  2BQZ A;  3BO5 A;  5T0K A;  3DB5 A;  4NVQ A;  5LSZ A;  2O8J A;  3M53 A;  3MO5 A;  4AU7 A;  1N3J A;  2W5Y A; 
#chains in the Genus database with same CATH homology
 3M54 A;  3RIB A;  1N6A A;  4J7I A;  4BUP A;  3S7F A;  5T5G A;  1N6C A;  4LDG A;  3M59 A;  5EG2 A;  4IJD A;  3RJW A;  5F6K C;  4MI5 A;  3M55 A;  4J7F A;  2R3A A;  4NJ5 A;  5AYF A;  3M56 A;  3OXF A;  5CPR B;  2G46 A;  1ML9 A;  3EP0 A;  4O30 A;  3F9X A;  3F9Y A;  4FMU A;  5F5E A;  4C1Q A;  4QEN A;  3MO2 A;  3M58 A;  3OOI A;  3SW9 A;  4O6F A;  3F9W A;  3OXL A;  3RQ4 A;  5F6L A;  5KJN A;  3QWW A;  5TH7 A;  1H3I A;  4H12 A;  3SWC A;  3K5K A;  4QEP A;  3HNA A;  3IHX A;  5JIY A;  3DAL A;  3M57 A;  5HI7 A;  3PDN A;  4YNM A;  3TG4 A;  1MVH A;  5EX3 A;  4YNP A;  1MUF A;  4J8O A;  5TEG A;  5JJ0 A;  5T0M A;  3RU0 A;  5JIN A;  1XQH A;  3N71 A;  3RAY A;  1O9S A;  4YPE A;  5ARG A;  3CBP A;  4QEO A;  4J83 A;  2JV0 A;  2QPW A;  2F69 A;  2RFI A;  3QWP A;  3VV0 A;  4JDS A;  2IGQ A;  1ZKK A;  3S8P A;  4E47 A;  5JHN A;  4IJ8 A;  5EX0 A;  5LSX A;  3S7J A;  5KJM A;  5CCM A;  3KMT A;  3MEK A;  3FPD A;  3KMJ A;  3OS5 A;  5ARF A;  4YPU A;  3KMA A;  4RZ0 A;  3M5A A;  2W5Z A;  3OXG A;  3OPE A;  4YPA A;  3TG5 A;  3QWV A;  3CBO A;  1PEG A;  3S7B A;  4JLG A;  4Z4P A;  3MO0 A;  3CBM A;  4YND A;  3VUZ A;  5HQ8 A;  3F9Z A;  4MI0 A;  5KJK A;  5F59 A;  1MVX A;  5TTF A;  5CCL A;  5KJL A;  4WUY A;  4I51 A;  1MT6 A;  3S7D A;  2BQZ A;  3BO5 A;  5T0K A;  3DB5 A;  4NVQ A;  5LSZ A;  2O8J A;  3M53 A;  3MO5 A;  4AU7 A;  1N3J A;  2W5Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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