1PEGA

Structural basis for the product specificity of histone lysine methyltransferases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
293
structure length
266
Chain Sequence
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNCLCGTAKCRGYLW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the product specificity of histone lysine methyltransferases
pubmed doi rcsb
source organism Neurospora crassa
molecule tags Transferase
molecule keywords histone H3 methyltransferase DIM-5
total genus 44
structure length 266
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1pegA00
5KJLA 3MEKA 4QEOA 3M5AA 5CPRB 5JHNA 3QWWA 5ARGA 3RAYA 2IGQA 5LSZA 4H12A 1MUFA 5T5GA 4YPUA 4O30A 3OXLA 4QENA 3MO0A 4LDGA 4MI0A 3OXGA 3OOIA 3OS5A 3S8PA 5KJNA 1MVXA 1O9SA 2RFIA 3F9WA 4C1QA 3N71A 4YNPA 5KJKA 4JDSA 5F59A 5F6KC 5TTFA 3M57A 3SWCA 1XQHA 2O8JA 2JV0A 4J7FA 2F69A 3K5KA 4RZ0A 1N3JA 4BUPA 3RIBA 5EX3A 5AYFA 5KJMA 2QPWA 3QWVA 2R3AA 1ZKKA 5LSXA 3KMTA 4YNDA 3F9ZA 4FMUA 3OXFA 1PEGA 5T0KA 5HQ8A 3CBOA 4I51A 3OPEA 4Z4PA 2W5YA 3S7JA 5CCLA 2W5ZA 4J8OA 3QWPA 3CBMA 5EG2A 5F5EA 3S7BA 3FPDA 4YPAA 5F6LA 3DALA 5JIYA 3RQ4A 4E47A 4NJ5A 4J83A 3MO5A 3VV0A 3SW9A 4IJ8A 5T0MA 5TH7A 3TG5A 5JINA 4QEPA 1H3IA 3CBPA 3HNAA 3M54A 5ARFA 1MVHA 3MO2A 3F9YA 4O6FA 3RJWA 3M56A 1ML9A 3M58A 3S7DA 2G46A 5JJ0A 5CCMA 1MT6A 3BO5A 4NVQA 3M55A 4MI5A 4IJDA 3VUZA 5TEGA 3F9XA 4YPEA 3S7FA 2BQZA 3RU0A 5HI7A 4AU7A 1N6AA 3DB5A 3M53A 3IHXA 4WUYA 3KMAA 3PDNA 3KMJA 4YNMA 3EP0A 3TG4A 1N6CA 4J7IA 3M59A 4JLGA 5EX0A
chains in the Genus database with same CATH superfamily
5KJLA 3MEKA 4QEOA 3M5AA 5CPRB 5JHNA 3QWWA 5ARGA 3RAYA 2IGQA 5LSZA 4H12A 1MUFA 5T5GA 4YPUA 4O30A 3OXLA 4QENA 3MO0A 4LDGA 4MI0A 3OXGA 3OOIA 3OS5A 3S8PA 5KJNA 1MVXA 1O9SA 2RFIA 3F9WA 4C1QA 3N71A 4YNPA 5KJKA 4JDSA 5F59A 5F6KC 5TTFA 3M57A 3SWCA 1XQHA 2O8JA 2JV0A 4J7FA 2F69A 3K5KA 4RZ0A 1N3JA 4BUPA 3RIBA 5EX3A 5AYFA 5KJMA 2QPWA 3QWVA 2R3AA 1ZKKA 5LSXA 3KMTA 4YNDA 3F9ZA 4FMUA 3OXFA 1PEGA 5T0KA 5HQ8A 3CBOA 4I51A 3OPEA 4Z4PA 2W5YA 3S7JA 5CCLA 2W5ZA 4J8OA 3QWPA 3CBMA 5EG2A 5F5EA 3S7BA 3FPDA 4YPAA 5F6LA 3DALA 5JIYA 3RQ4A 4E47A 4NJ5A 4J83A 3MO5A 3VV0A 3SW9A 4IJ8A 5T0MA 5TH7A 3TG5A 5JINA 4QEPA 1H3IA 3CBPA 3HNAA 3M54A 5ARFA 1MVHA 3MO2A 3F9YA 4O6FA 3RJWA 3M56A 1ML9A 3M58A 3S7DA 2G46A 5JJ0A 5CCMA 1MT6A 3BO5A 4NVQA 3M55A 4MI5A 4IJDA 3VUZA 5TEGA 3F9XA 4YPEA 3S7FA 2BQZA 3RU0A 5HI7A 4AU7A 1N6AA 3DB5A 3M53A 3IHXA 4WUYA 3KMAA 3PDNA 3KMJA 4YNMA 3EP0A 3TG4A 1N6CA 4J7IA 3M59A 4JLGA 5EX0A
chains in the Genus database with same CATH topology
5KJLA 3MEKA 4QEOA 3M5AA 5CPRB 5JHNA 3QWWA 5ARGA 3RAYA 2IGQA 5LSZA 4H12A 1MUFA 5T5GA 4YPUA 4O30A 3OXLA 4QENA 3MO0A 4LDGA 4MI0A 3OXGA 3OOIA 3OS5A 3S8PA 5KJNA 1MVXA 1O9SA 2RFIA 3F9WA 4C1QA 3N71A 4YNPA 5KJKA 4JDSA 5F59A 5F6KC 5TTFA 3M57A 3SWCA 1XQHA 2O8JA 2JV0A 4J7FA 2F69A 3K5KA 4RZ0A 1N3JA 4BUPA 3RIBA 5EX3A 5AYFA 5KJMA 2QPWA 3QWVA 2R3AA 1ZKKA 5LSXA 3KMTA 4YNDA 3F9ZA 4FMUA 3OXFA 1PEGA 5T0KA 5HQ8A 3CBOA 4I51A 3OPEA 4Z4PA 2W5YA 3S7JA 5CCLA 2W5ZA 4J8OA 3QWPA 3CBMA 5EG2A 5F5EA 3S7BA 3FPDA 4YPAA 5F6LA 3DALA 5JIYA 3RQ4A 4E47A 4NJ5A 4J83A 3MO5A 3VV0A 3SW9A 4IJ8A 5T0MA 5TH7A 3TG5A 5JINA 4QEPA 1H3IA 3CBPA 3HNAA 3M54A 5ARFA 1MVHA 3MO2A 3F9YA 4O6FA 3RJWA 3M56A 1ML9A 3M58A 3S7DA 2G46A 5JJ0A 5CCMA 1MT6A 3BO5A 4NVQA 3M55A 4MI5A 4IJDA 3VUZA 5TEGA 3F9XA 4YPEA 3S7FA 2BQZA 3RU0A 5HI7A 4AU7A 1N6AA 3DB5A 3M53A 3IHXA 4WUYA 3KMAA 3PDNA 3KMJA 4YNMA 3EP0A 3TG4A 1N6CA 4J7IA 3M59A 4JLGA 5EX0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KJL A;  3MEK A;  4QEO A;  3M5A A;  5CPR B;  5JHN A;  3QWW A;  5ARG A;  3RAY A;  2IGQ A;  5LSZ A;  4H12 A;  1MUF A;  5T5G A;  4YPU A;  4O30 A;  3OXL A;  4QEN A;  3MO0 A;  4LDG A;  4MI0 A;  3OXG A;  3OOI A;  3OS5 A;  3S8P A;  5KJN A;  1MVX A;  1O9S A;  2RFI A;  3F9W A;  4C1Q A;  3N71 A;  4YNP A;  5KJK A;  4JDS A;  5F59 A;  5F6K C;  5TTF A;  3M57 A;  3SWC A;  1XQH A;  2O8J A;  2JV0 A;  4J7F A;  2F69 A;  3K5K A;  4RZ0 A;  1N3J A;  4BUP A;  3RIB A;  5EX3 A;  5AYF A;  5KJM A;  2QPW A;  3QWV A;  2R3A A;  1ZKK A;  5LSX A;  3KMT A;  4YND A;  3F9Z A;  4FMU A;  3OXF A;  1PEG A;  5T0K A;  5HQ8 A;  3CBO A;  4I51 A;  3OPE A;  4Z4P A;  2W5Y A;  3S7J A;  5CCL A;  2W5Z A;  4J8O A;  3QWP A;  3CBM A;  5EG2 A;  5F5E A;  3S7B A;  3FPD A;  4YPA A;  5F6L A;  3DAL A;  5JIY A;  3RQ4 A;  4E47 A;  4NJ5 A;  4J83 A;  3MO5 A;  3VV0 A;  3SW9 A;  4IJ8 A;  5T0M A;  5TH7 A;  3TG5 A;  5JIN A;  4QEP A;  1H3I A;  3CBP A;  3HNA A;  3M54 A;  5ARF A;  1MVH A;  3MO2 A;  3F9Y A;  4O6F A;  3RJW A;  3M56 A;  1ML9 A;  3M58 A;  3S7D A;  2G46 A;  5JJ0 A;  5CCM A;  1MT6 A;  3BO5 A;  4NVQ A;  3M55 A;  4MI5 A;  4IJD A;  3VUZ A;  5TEG A;  3F9X A;  4YPE A;  3S7F A;  2BQZ A;  3RU0 A;  5HI7 A;  4AU7 A;  1N6A A;  3DB5 A;  3M53 A;  3IHX A;  4WUY A;  3KMA A;  3PDN A;  3KMJ A;  4YNM A;  3EP0 A;  3TG4 A;  1N6C A;  4J7I A;  3M59 A;  4JLG A;  5EX0 A; 
#chains in the Genus database with same CATH topology
 5KJL A;  3MEK A;  4QEO A;  3M5A A;  5CPR B;  5JHN A;  3QWW A;  5ARG A;  3RAY A;  2IGQ A;  5LSZ A;  4H12 A;  1MUF A;  5T5G A;  4YPU A;  4O30 A;  3OXL A;  4QEN A;  3MO0 A;  4LDG A;  4MI0 A;  3OXG A;  3OOI A;  3OS5 A;  3S8P A;  5KJN A;  1MVX A;  1O9S A;  2RFI A;  3F9W A;  4C1Q A;  3N71 A;  4YNP A;  5KJK A;  4JDS A;  5F59 A;  5F6K C;  5TTF A;  3M57 A;  3SWC A;  1XQH A;  2O8J A;  2JV0 A;  4J7F A;  2F69 A;  3K5K A;  4RZ0 A;  1N3J A;  4BUP A;  3RIB A;  5EX3 A;  5AYF A;  5KJM A;  2QPW A;  3QWV A;  2R3A A;  1ZKK A;  5LSX A;  3KMT A;  4YND A;  3F9Z A;  4FMU A;  3OXF A;  1PEG A;  5T0K A;  5HQ8 A;  3CBO A;  4I51 A;  3OPE A;  4Z4P A;  2W5Y A;  3S7J A;  5CCL A;  2W5Z A;  4J8O A;  3QWP A;  3CBM A;  5EG2 A;  5F5E A;  3S7B A;  3FPD A;  4YPA A;  5F6L A;  3DAL A;  5JIY A;  3RQ4 A;  4E47 A;  4NJ5 A;  4J83 A;  3MO5 A;  3VV0 A;  3SW9 A;  4IJ8 A;  5T0M A;  5TH7 A;  3TG5 A;  5JIN A;  4QEP A;  1H3I A;  3CBP A;  3HNA A;  3M54 A;  5ARF A;  1MVH A;  3MO2 A;  3F9Y A;  4O6F A;  3RJW A;  3M56 A;  1ML9 A;  3M58 A;  3S7D A;  2G46 A;  5JJ0 A;  5CCM A;  1MT6 A;  3BO5 A;  4NVQ A;  3M55 A;  4MI5 A;  4IJD A;  3VUZ A;  5TEG A;  3F9X A;  4YPE A;  3S7F A;  2BQZ A;  3RU0 A;  5HI7 A;  4AU7 A;  1N6A A;  3DB5 A;  3M53 A;  3IHX A;  4WUY A;  3KMA A;  3PDN A;  3KMJ A;  4YNM A;  3EP0 A;  3TG4 A;  1N6C A;  4J7I A;  3M59 A;  4JLG A;  5EX0 A; 
#chains in the Genus database with same CATH homology
 5KJL A;  3MEK A;  4QEO A;  3M5A A;  5CPR B;  5JHN A;  3QWW A;  5ARG A;  3RAY A;  2IGQ A;  5LSZ A;  4H12 A;  1MUF A;  5T5G A;  4YPU A;  4O30 A;  3OXL A;  4QEN A;  3MO0 A;  4LDG A;  4MI0 A;  3OXG A;  3OOI A;  3OS5 A;  3S8P A;  5KJN A;  1MVX A;  1O9S A;  2RFI A;  3F9W A;  4C1Q A;  3N71 A;  4YNP A;  5KJK A;  4JDS A;  5F59 A;  5F6K C;  5TTF A;  3M57 A;  3SWC A;  1XQH A;  2O8J A;  2JV0 A;  4J7F A;  2F69 A;  3K5K A;  4RZ0 A;  1N3J A;  4BUP A;  3RIB A;  5EX3 A;  5AYF A;  5KJM A;  2QPW A;  3QWV A;  2R3A A;  1ZKK A;  5LSX A;  3KMT A;  4YND A;  3F9Z A;  4FMU A;  3OXF A;  1PEG A;  5T0K A;  5HQ8 A;  3CBO A;  4I51 A;  3OPE A;  4Z4P A;  2W5Y A;  3S7J A;  5CCL A;  2W5Z A;  4J8O A;  3QWP A;  3CBM A;  5EG2 A;  5F5E A;  3S7B A;  3FPD A;  4YPA A;  5F6L A;  3DAL A;  5JIY A;  3RQ4 A;  4E47 A;  4NJ5 A;  4J83 A;  3MO5 A;  3VV0 A;  3SW9 A;  4IJ8 A;  5T0M A;  5TH7 A;  3TG5 A;  5JIN A;  4QEP A;  1H3I A;  3CBP A;  3HNA A;  3M54 A;  5ARF A;  1MVH A;  3MO2 A;  3F9Y A;  4O6F A;  3RJW A;  3M56 A;  1ML9 A;  3M58 A;  3S7D A;  2G46 A;  5JJ0 A;  5CCM A;  1MT6 A;  3BO5 A;  4NVQ A;  3M55 A;  4MI5 A;  4IJD A;  3VUZ A;  5TEG A;  3F9X A;  4YPE A;  3S7F A;  2BQZ A;  3RU0 A;  5HI7 A;  4AU7 A;  1N6A A;  3DB5 A;  3M53 A;  3IHX A;  4WUY A;  3KMA A;  3PDN A;  3KMJ A;  4YNM A;  3EP0 A;  3TG4 A;  1N6C A;  4J7I A;  3M59 A;  4JLG A;  5EX0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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