1PEGA

Structural basis for the product specificity of histone lysine methyltransferases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
293
structure length
266
Chain Sequence
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNCLCGTAKCRGYLW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the product specificity of histone lysine methyltransferases
pubmed doi rcsb
source organism Neurospora crassa
molecule tags Transferase
molecule keywords histone H3 methyltransferase DIM-5
total genus 44
structure length 266
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1pegA00
3OOIA 5CCMA 3N71A 5KJMA 3TG5A 5LSZA 4WUYA 4YPAA 5F6LA 3KMTA 5CCLA 3MO5A 3CBOA 5JIYA 3S7BA 3M59A 5F6KC 2O8JA 2BQZA 2F69A 4JLGA 3F9YA 4JDSA 3DB5A 3MEKA 3S7FA 4J8OA 5EX0A 3BO5A 5JINA 5TEGA 1MVHA 5JJ0A 5KJKA 3MO2A 5T0MA 3VV0A 3VUZA 5TTFA 4J83A 1MUFA 2G46A 3M53A 4H12A 4FMUA 3F9WA 5ARFA 4YNDA 3F9XA 2JV0A 4O6FA 5KJLA 3DALA 3OPEA 1ZKKA 4J7FA 5JHNA 2IGQA 3QWVA 4MI0A 3MO0A 4NJ5A 4LDGA 3S7JA 3RIBA 4J7IA 5F5EA 3KMAA 3OXLA 4AU7A 4QEOA 3S7DA 5EX3A 3QWPA 2RFIA 2W5ZA 3PDNA 1N6CA 3QWWA 1ML9A 4NVQA 4YNMA 4RZ0A 1XQHA 4I51A 3OXFA 3OS5A 4YPEA 3KMJA 5HI7A 2W5YA 1H3IA 4IJDA 3RJWA 3M5AA 3M58A 1MT6A 5LSXA 3HNAA 3IHXA 5EG2A 1N6AA 5CPRB 3EP0A 5T5GA 3RQ4A 4O30A 5T0KA 5F59A 1PEGA 4YNPA 1O9SA 3SW9A 3RAYA 4C1QA 2QPWA 3M54A 3SWCA 3OXGA 3F9ZA 3CBMA 3K5KA 3M56A 5TH7A 2R3AA 4MI5A 3FPDA 4BUPA 5KJNA 3S8PA 4YPUA 3M55A 4QENA 3CBPA 4IJ8A 3RU0A 3TG4A 4E47A 5AYFA 5ARGA 4Z4PA 5HQ8A 1MVXA 4QEPA 3M57A 1N3JA
chains in the Genus database with same CATH superfamily
3OOIA 5CCMA 3N71A 5KJMA 3TG5A 5LSZA 4WUYA 4YPAA 5F6LA 3KMTA 5CCLA 3MO5A 3CBOA 5JIYA 3S7BA 3M59A 5F6KC 2O8JA 2BQZA 2F69A 4JLGA 3F9YA 4JDSA 3DB5A 3MEKA 3S7FA 4J8OA 5EX0A 3BO5A 5JINA 5TEGA 1MVHA 5JJ0A 5KJKA 3MO2A 5T0MA 3VV0A 3VUZA 5TTFA 4J83A 1MUFA 2G46A 3M53A 4H12A 4FMUA 3F9WA 5ARFA 4YNDA 3F9XA 2JV0A 4O6FA 5KJLA 3DALA 3OPEA 1ZKKA 4J7FA 5JHNA 2IGQA 3QWVA 4MI0A 3MO0A 4NJ5A 4LDGA 3S7JA 3RIBA 4J7IA 5F5EA 3KMAA 3OXLA 4AU7A 4QEOA 3S7DA 5EX3A 3QWPA 2RFIA 2W5ZA 3PDNA 1N6CA 3QWWA 1ML9A 4NVQA 4YNMA 4RZ0A 1XQHA 4I51A 3OXFA 3OS5A 4YPEA 3KMJA 5HI7A 2W5YA 1H3IA 4IJDA 3RJWA 3M5AA 3M58A 1MT6A 5LSXA 3HNAA 3IHXA 5EG2A 1N6AA 5CPRB 3EP0A 5T5GA 3RQ4A 4O30A 5T0KA 5F59A 1PEGA 4YNPA 1O9SA 3SW9A 3RAYA 4C1QA 2QPWA 3M54A 3SWCA 3OXGA 3F9ZA 3CBMA 3K5KA 3M56A 5TH7A 2R3AA 4MI5A 3FPDA 4BUPA 5KJNA 3S8PA 4YPUA 3M55A 4QENA 3CBPA 4IJ8A 3RU0A 3TG4A 4E47A 5AYFA 5ARGA 4Z4PA 5HQ8A 1MVXA 4QEPA 3M57A 1N3JA
chains in the Genus database with same CATH topology
3OOIA 5CCMA 3N71A 5KJMA 3TG5A 5LSZA 4WUYA 4YPAA 5F6LA 3KMTA 5CCLA 3MO5A 3CBOA 5JIYA 3S7BA 3M59A 5F6KC 2O8JA 2BQZA 2F69A 4JLGA 3F9YA 4JDSA 3DB5A 3MEKA 3S7FA 4J8OA 5EX0A 3BO5A 5JINA 5TEGA 1MVHA 5JJ0A 5KJKA 3MO2A 5T0MA 3VV0A 3VUZA 5TTFA 4J83A 1MUFA 2G46A 3M53A 4H12A 4FMUA 3F9WA 5ARFA 4YNDA 3F9XA 2JV0A 4O6FA 5KJLA 3DALA 3OPEA 1ZKKA 4J7FA 5JHNA 2IGQA 3QWVA 4MI0A 3MO0A 4NJ5A 4LDGA 3S7JA 3RIBA 4J7IA 5F5EA 3KMAA 3OXLA 4AU7A 4QEOA 3S7DA 5EX3A 3QWPA 2RFIA 2W5ZA 3PDNA 1N6CA 3QWWA 1ML9A 4NVQA 4YNMA 4RZ0A 1XQHA 4I51A 3OXFA 3OS5A 4YPEA 3KMJA 5HI7A 2W5YA 1H3IA 4IJDA 3RJWA 3M5AA 3M58A 1MT6A 5LSXA 3HNAA 3IHXA 5EG2A 1N6AA 5CPRB 3EP0A 5T5GA 3RQ4A 4O30A 5T0KA 5F59A 1PEGA 4YNPA 1O9SA 3SW9A 3RAYA 4C1QA 2QPWA 3M54A 3SWCA 3OXGA 3F9ZA 3CBMA 3K5KA 3M56A 5TH7A 2R3AA 4MI5A 3FPDA 4BUPA 5KJNA 3S8PA 4YPUA 3M55A 4QENA 3CBPA 4IJ8A 3RU0A 3TG4A 4E47A 5AYFA 5ARGA 4Z4PA 5HQ8A 1MVXA 4QEPA 3M57A 1N3JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OOI A;  5CCM A;  3N71 A;  5KJM A;  3TG5 A;  5LSZ A;  4WUY A;  4YPA A;  5F6L A;  3KMT A;  5CCL A;  3MO5 A;  3CBO A;  5JIY A;  3S7B A;  3M59 A;  5F6K C;  2O8J A;  2BQZ A;  2F69 A;  4JLG A;  3F9Y A;  4JDS A;  3DB5 A;  3MEK A;  3S7F A;  4J8O A;  5EX0 A;  3BO5 A;  5JIN A;  5TEG A;  1MVH A;  5JJ0 A;  5KJK A;  3MO2 A;  5T0M A;  3VV0 A;  3VUZ A;  5TTF A;  4J83 A;  1MUF A;  2G46 A;  3M53 A;  4H12 A;  4FMU A;  3F9W A;  5ARF A;  4YND A;  3F9X A;  2JV0 A;  4O6F A;  5KJL A;  3DAL A;  3OPE A;  1ZKK A;  4J7F A;  5JHN A;  2IGQ A;  3QWV A;  4MI0 A;  3MO0 A;  4NJ5 A;  4LDG A;  3S7J A;  3RIB A;  4J7I A;  5F5E A;  3KMA A;  3OXL A;  4AU7 A;  4QEO A;  3S7D A;  5EX3 A;  3QWP A;  2RFI A;  2W5Z A;  3PDN A;  1N6C A;  3QWW A;  1ML9 A;  4NVQ A;  4YNM A;  4RZ0 A;  1XQH A;  4I51 A;  3OXF A;  3OS5 A;  4YPE A;  3KMJ A;  5HI7 A;  2W5Y A;  1H3I A;  4IJD A;  3RJW A;  3M5A A;  3M58 A;  1MT6 A;  5LSX A;  3HNA A;  3IHX A;  5EG2 A;  1N6A A;  5CPR B;  3EP0 A;  5T5G A;  3RQ4 A;  4O30 A;  5T0K A;  5F59 A;  1PEG A;  4YNP A;  1O9S A;  3SW9 A;  3RAY A;  4C1Q A;  2QPW A;  3M54 A;  3SWC A;  3OXG A;  3F9Z A;  3CBM A;  3K5K A;  3M56 A;  5TH7 A;  2R3A A;  4MI5 A;  3FPD A;  4BUP A;  5KJN A;  3S8P A;  4YPU A;  3M55 A;  4QEN A;  3CBP A;  4IJ8 A;  3RU0 A;  3TG4 A;  4E47 A;  5AYF A;  5ARG A;  4Z4P A;  5HQ8 A;  1MVX A;  4QEP A;  3M57 A;  1N3J A; 
#chains in the Genus database with same CATH topology
 3OOI A;  5CCM A;  3N71 A;  5KJM A;  3TG5 A;  5LSZ A;  4WUY A;  4YPA A;  5F6L A;  3KMT A;  5CCL A;  3MO5 A;  3CBO A;  5JIY A;  3S7B A;  3M59 A;  5F6K C;  2O8J A;  2BQZ A;  2F69 A;  4JLG A;  3F9Y A;  4JDS A;  3DB5 A;  3MEK A;  3S7F A;  4J8O A;  5EX0 A;  3BO5 A;  5JIN A;  5TEG A;  1MVH A;  5JJ0 A;  5KJK A;  3MO2 A;  5T0M A;  3VV0 A;  3VUZ A;  5TTF A;  4J83 A;  1MUF A;  2G46 A;  3M53 A;  4H12 A;  4FMU A;  3F9W A;  5ARF A;  4YND A;  3F9X A;  2JV0 A;  4O6F A;  5KJL A;  3DAL A;  3OPE A;  1ZKK A;  4J7F A;  5JHN A;  2IGQ A;  3QWV A;  4MI0 A;  3MO0 A;  4NJ5 A;  4LDG A;  3S7J A;  3RIB A;  4J7I A;  5F5E A;  3KMA A;  3OXL A;  4AU7 A;  4QEO A;  3S7D A;  5EX3 A;  3QWP A;  2RFI A;  2W5Z A;  3PDN A;  1N6C A;  3QWW A;  1ML9 A;  4NVQ A;  4YNM A;  4RZ0 A;  1XQH A;  4I51 A;  3OXF A;  3OS5 A;  4YPE A;  3KMJ A;  5HI7 A;  2W5Y A;  1H3I A;  4IJD A;  3RJW A;  3M5A A;  3M58 A;  1MT6 A;  5LSX A;  3HNA A;  3IHX A;  5EG2 A;  1N6A A;  5CPR B;  3EP0 A;  5T5G A;  3RQ4 A;  4O30 A;  5T0K A;  5F59 A;  1PEG A;  4YNP A;  1O9S A;  3SW9 A;  3RAY A;  4C1Q A;  2QPW A;  3M54 A;  3SWC A;  3OXG A;  3F9Z A;  3CBM A;  3K5K A;  3M56 A;  5TH7 A;  2R3A A;  4MI5 A;  3FPD A;  4BUP A;  5KJN A;  3S8P A;  4YPU A;  3M55 A;  4QEN A;  3CBP A;  4IJ8 A;  3RU0 A;  3TG4 A;  4E47 A;  5AYF A;  5ARG A;  4Z4P A;  5HQ8 A;  1MVX A;  4QEP A;  3M57 A;  1N3J A; 
#chains in the Genus database with same CATH homology
 3OOI A;  5CCM A;  3N71 A;  5KJM A;  3TG5 A;  5LSZ A;  4WUY A;  4YPA A;  5F6L A;  3KMT A;  5CCL A;  3MO5 A;  3CBO A;  5JIY A;  3S7B A;  3M59 A;  5F6K C;  2O8J A;  2BQZ A;  2F69 A;  4JLG A;  3F9Y A;  4JDS A;  3DB5 A;  3MEK A;  3S7F A;  4J8O A;  5EX0 A;  3BO5 A;  5JIN A;  5TEG A;  1MVH A;  5JJ0 A;  5KJK A;  3MO2 A;  5T0M A;  3VV0 A;  3VUZ A;  5TTF A;  4J83 A;  1MUF A;  2G46 A;  3M53 A;  4H12 A;  4FMU A;  3F9W A;  5ARF A;  4YND A;  3F9X A;  2JV0 A;  4O6F A;  5KJL A;  3DAL A;  3OPE A;  1ZKK A;  4J7F A;  5JHN A;  2IGQ A;  3QWV A;  4MI0 A;  3MO0 A;  4NJ5 A;  4LDG A;  3S7J A;  3RIB A;  4J7I A;  5F5E A;  3KMA A;  3OXL A;  4AU7 A;  4QEO A;  3S7D A;  5EX3 A;  3QWP A;  2RFI A;  2W5Z A;  3PDN A;  1N6C A;  3QWW A;  1ML9 A;  4NVQ A;  4YNM A;  4RZ0 A;  1XQH A;  4I51 A;  3OXF A;  3OS5 A;  4YPE A;  3KMJ A;  5HI7 A;  2W5Y A;  1H3I A;  4IJD A;  3RJW A;  3M5A A;  3M58 A;  1MT6 A;  5LSX A;  3HNA A;  3IHX A;  5EG2 A;  1N6A A;  5CPR B;  3EP0 A;  5T5G A;  3RQ4 A;  4O30 A;  5T0K A;  5F59 A;  1PEG A;  4YNP A;  1O9S A;  3SW9 A;  3RAY A;  4C1Q A;  2QPW A;  3M54 A;  3SWC A;  3OXG A;  3F9Z A;  3CBM A;  3K5K A;  3M56 A;  5TH7 A;  2R3A A;  4MI5 A;  3FPD A;  4BUP A;  5KJN A;  3S8P A;  4YPU A;  3M55 A;  4QEN A;  3CBP A;  4IJ8 A;  3RU0 A;  3TG4 A;  4E47 A;  5AYF A;  5ARG A;  4Z4P A;  5HQ8 A;  1MVX A;  4QEP A;  3M57 A;  1N3J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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