1MT6A

Structure of histone h3 k4-specific methyltransferase set7/9 with adohcy
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
280
structure length
280
Chain Sequence
TLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords SET9
total genus 62
structure length 280
sequence length 280
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mt6A01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mt6A02
2W5ZA 3QWWA 4H12A 4BUPA 3MO2A 5T0MA 5JINA 3TG4A 3OOIA 5KJLA 2IGQA 3M53A 3CBOA 3OPEA 5ARFA 3F9YA 1N6CA 3DALA 3S7FA 2W5YA 5HI7A 3RU0A 4QEOA 3CBMA 1MVXA 3RQ4A 3OXGA 2F69A 5T5GA 3VV0A 3CBPA 5EX0A 1ML9A 3SW9A 3KMTA 3S8PA 5EX3A 3S7BA 4O6FA 5JIYA 3M56A 4J7FA 3M55A 5EG2A 4FMUA 3DB5A 4C1QA 2JV0A 4QEPA 4QENA 3BO5A 1N3JA 3M58A 4RZ0A 5ARGA 4YPEA 4J83A 1MT6A 5JJ0A 1XQHA 3K5KA 4E47A 3TG5A 4O30A 3OXFA 2O8JA 3M54A 1ZKKA 3RAYA 4JLGA 3EP0A 3F9XA 3S7DA 5F5EA 2R3AA 5F6LA 5JHNA 4YNMA 5TTFA 3QWPA 4IJ8A 5TEGA 2G46A 5CPRB 5LSZA 3OS5A 5AYFA 4YPAA 3M5AA 4J8OA 2RFIA 4YNDA 5T0KA 4JDSA 4J7IA 4NVQA 3RIBA 4YPUA 3PDNA 3MO5A 4WUYA 3OXLA 4MI0A 1H3IA 5HQ8A 3M57A 5KJMA 4YNPA 3M59A 5KJNA 4Z4PA 3RJWA 3S7JA 1MUFA 3MEKA 1PEGA 1O9SA 3HNAA 5TH7A 5KJKA 3IHXA 4LDGA 3MO0A 5LSXA 1MVHA 5F59A 1N6AA 2BQZA 4I51A 3QWVA 4NJ5A 4MI5A 2QPWA 3KMAA 3KMJA 3N71A 5CCLA 4IJDA 3VUZA 5CCMA 4AU7A 3FPDA 3SWCA 5F6KC 3F9WA 3F9ZA
chains in the Genus database with same CATH superfamily
2W5ZA 3QWWA 4H12A 4BUPA 3MO2A 5T0MA 5JINA 3TG4A 3OOIA 5KJLA 2IGQA 3M53A 3CBOA 3OPEA 5ARFA 3F9YA 1N6CA 3DALA 3S7FA 2W5YA 5HI7A 3RU0A 4QEOA 3CBMA 1MVXA 3RQ4A 3OXGA 2F69A 5T5GA 3VV0A 3CBPA 5EX0A 1ML9A 3SW9A 3KMTA 3S8PA 5EX3A 3S7BA 4O6FA 5JIYA 3M56A 4J7FA 3M55A 5EG2A 4FMUA 3DB5A 4C1QA 2JV0A 4QEPA 4QENA 3BO5A 1N3JA 3M58A 4RZ0A 5ARGA 4YPEA 4J83A 1MT6A 5JJ0A 1XQHA 3K5KA 4E47A 3TG5A 4O30A 3OXFA 2O8JA 3M54A 1ZKKA 3RAYA 4JLGA 3EP0A 3F9XA 3S7DA 5F5EA 2R3AA 5F6LA 5JHNA 4YNMA 5TTFA 3QWPA 4IJ8A 5TEGA 2G46A 5CPRB 5LSZA 3OS5A 5AYFA 4YPAA 3M5AA 4J8OA 2RFIA 4YNDA 5T0KA 4JDSA 4J7IA 4NVQA 3RIBA 4YPUA 3PDNA 3MO5A 4WUYA 3OXLA 4MI0A 1H3IA 5HQ8A 3M57A 5KJMA 4YNPA 3M59A 5KJNA 4Z4PA 3RJWA 3S7JA 1MUFA 3MEKA 1PEGA 1O9SA 3HNAA 5TH7A 5KJKA 3IHXA 4LDGA 3MO0A 5LSXA 1MVHA 5F59A 1N6AA 2BQZA 4I51A 3QWVA 4NJ5A 4MI5A 2QPWA 3KMAA 3KMJA 3N71A 5CCLA 4IJDA 3VUZA 5CCMA 4AU7A 3FPDA 3SWCA 5F6KC 3F9WA 3F9ZA
chains in the Genus database with same CATH topology
2W5ZA 3QWWA 4H12A 4BUPA 3MO2A 5T0MA 5JINA 3TG4A 3OOIA 5KJLA 2IGQA 3M53A 3CBOA 3OPEA 5ARFA 3F9YA 1N6CA 3DALA 3S7FA 2W5YA 5HI7A 3RU0A 4QEOA 3CBMA 1MVXA 3RQ4A 3OXGA 2F69A 5T5GA 3VV0A 3CBPA 5EX0A 1ML9A 3SW9A 3KMTA 3S8PA 5EX3A 3S7BA 4O6FA 5JIYA 3M56A 4J7FA 3M55A 5EG2A 4FMUA 3DB5A 4C1QA 2JV0A 4QEPA 4QENA 3BO5A 1N3JA 3M58A 4RZ0A 5ARGA 4YPEA 4J83A 1MT6A 5JJ0A 1XQHA 3K5KA 4E47A 3TG5A 4O30A 3OXFA 2O8JA 3M54A 1ZKKA 3RAYA 4JLGA 3EP0A 3F9XA 3S7DA 5F5EA 2R3AA 5F6LA 5JHNA 4YNMA 5TTFA 3QWPA 4IJ8A 5TEGA 2G46A 5CPRB 5LSZA 3OS5A 5AYFA 4YPAA 3M5AA 4J8OA 2RFIA 4YNDA 5T0KA 4JDSA 4J7IA 4NVQA 3RIBA 4YPUA 3PDNA 3MO5A 4WUYA 3OXLA 4MI0A 1H3IA 5HQ8A 3M57A 5KJMA 4YNPA 3M59A 5KJNA 4Z4PA 3RJWA 3S7JA 1MUFA 3MEKA 1PEGA 1O9SA 3HNAA 5TH7A 5KJKA 3IHXA 4LDGA 3MO0A 5LSXA 1MVHA 5F59A 1N6AA 2BQZA 4I51A 3QWVA 4NJ5A 4MI5A 2QPWA 3KMAA 3KMJA 3N71A 5CCLA 4IJDA 3VUZA 5CCMA 4AU7A 3FPDA 3SWCA 5F6KC 3F9WA 3F9ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W5Z A;  3QWW A;  4H12 A;  4BUP A;  3MO2 A;  5T0M A;  5JIN A;  3TG4 A;  3OOI A;  5KJL A;  2IGQ A;  3M53 A;  3CBO A;  3OPE A;  5ARF A;  3F9Y A;  1N6C A;  3DAL A;  3S7F A;  2W5Y A;  5HI7 A;  3RU0 A;  4QEO A;  3CBM A;  1MVX A;  3RQ4 A;  3OXG A;  2F69 A;  5T5G A;  3VV0 A;  3CBP A;  5EX0 A;  1ML9 A;  3SW9 A;  3KMT A;  3S8P A;  5EX3 A;  3S7B A;  4O6F A;  5JIY A;  3M56 A;  4J7F A;  3M55 A;  5EG2 A;  4FMU A;  3DB5 A;  4C1Q A;  2JV0 A;  4QEP A;  4QEN A;  3BO5 A;  1N3J A;  3M58 A;  4RZ0 A;  5ARG A;  4YPE A;  4J83 A;  1MT6 A;  5JJ0 A;  1XQH A;  3K5K A;  4E47 A;  3TG5 A;  4O30 A;  3OXF A;  2O8J A;  3M54 A;  1ZKK A;  3RAY A;  4JLG A;  3EP0 A;  3F9X A;  3S7D A;  5F5E A;  2R3A A;  5F6L A;  5JHN A;  4YNM A;  5TTF A;  3QWP A;  4IJ8 A;  5TEG A;  2G46 A;  5CPR B;  5LSZ A;  3OS5 A;  5AYF A;  4YPA A;  3M5A A;  4J8O A;  2RFI A;  4YND A;  5T0K A;  4JDS A;  4J7I A;  4NVQ A;  3RIB A;  4YPU A;  3PDN A;  3MO5 A;  4WUY A;  3OXL A;  4MI0 A;  1H3I A;  5HQ8 A;  3M57 A;  5KJM A;  4YNP A;  3M59 A;  5KJN A;  4Z4P A;  3RJW A;  3S7J A;  1MUF A;  3MEK A;  1PEG A;  1O9S A;  3HNA A;  5TH7 A;  5KJK A;  3IHX A;  4LDG A;  3MO0 A;  5LSX A;  1MVH A;  5F59 A;  1N6A A;  2BQZ A;  4I51 A;  3QWV A;  4NJ5 A;  4MI5 A;  2QPW A;  3KMA A;  3KMJ A;  3N71 A;  5CCL A;  4IJD A;  3VUZ A;  5CCM A;  4AU7 A;  3FPD A;  3SWC A;  5F6K C;  3F9W A;  3F9Z A; 
#chains in the Genus database with same CATH topology
 2W5Z A;  3QWW A;  4H12 A;  4BUP A;  3MO2 A;  5T0M A;  5JIN A;  3TG4 A;  3OOI A;  5KJL A;  2IGQ A;  3M53 A;  3CBO A;  3OPE A;  5ARF A;  3F9Y A;  1N6C A;  3DAL A;  3S7F A;  2W5Y A;  5HI7 A;  3RU0 A;  4QEO A;  3CBM A;  1MVX A;  3RQ4 A;  3OXG A;  2F69 A;  5T5G A;  3VV0 A;  3CBP A;  5EX0 A;  1ML9 A;  3SW9 A;  3KMT A;  3S8P A;  5EX3 A;  3S7B A;  4O6F A;  5JIY A;  3M56 A;  4J7F A;  3M55 A;  5EG2 A;  4FMU A;  3DB5 A;  4C1Q A;  2JV0 A;  4QEP A;  4QEN A;  3BO5 A;  1N3J A;  3M58 A;  4RZ0 A;  5ARG A;  4YPE A;  4J83 A;  1MT6 A;  5JJ0 A;  1XQH A;  3K5K A;  4E47 A;  3TG5 A;  4O30 A;  3OXF A;  2O8J A;  3M54 A;  1ZKK A;  3RAY A;  4JLG A;  3EP0 A;  3F9X A;  3S7D A;  5F5E A;  2R3A A;  5F6L A;  5JHN A;  4YNM A;  5TTF A;  3QWP A;  4IJ8 A;  5TEG A;  2G46 A;  5CPR B;  5LSZ A;  3OS5 A;  5AYF A;  4YPA A;  3M5A A;  4J8O A;  2RFI A;  4YND A;  5T0K A;  4JDS A;  4J7I A;  4NVQ A;  3RIB A;  4YPU A;  3PDN A;  3MO5 A;  4WUY A;  3OXL A;  4MI0 A;  1H3I A;  5HQ8 A;  3M57 A;  5KJM A;  4YNP A;  3M59 A;  5KJN A;  4Z4P A;  3RJW A;  3S7J A;  1MUF A;  3MEK A;  1PEG A;  1O9S A;  3HNA A;  5TH7 A;  5KJK A;  3IHX A;  4LDG A;  3MO0 A;  5LSX A;  1MVH A;  5F59 A;  1N6A A;  2BQZ A;  4I51 A;  3QWV A;  4NJ5 A;  4MI5 A;  2QPW A;  3KMA A;  3KMJ A;  3N71 A;  5CCL A;  4IJD A;  3VUZ A;  5CCM A;  4AU7 A;  3FPD A;  3SWC A;  5F6K C;  3F9W A;  3F9Z A; 
#chains in the Genus database with same CATH homology
 2W5Z A;  3QWW A;  4H12 A;  4BUP A;  3MO2 A;  5T0M A;  5JIN A;  3TG4 A;  3OOI A;  5KJL A;  2IGQ A;  3M53 A;  3CBO A;  3OPE A;  5ARF A;  3F9Y A;  1N6C A;  3DAL A;  3S7F A;  2W5Y A;  5HI7 A;  3RU0 A;  4QEO A;  3CBM A;  1MVX A;  3RQ4 A;  3OXG A;  2F69 A;  5T5G A;  3VV0 A;  3CBP A;  5EX0 A;  1ML9 A;  3SW9 A;  3KMT A;  3S8P A;  5EX3 A;  3S7B A;  4O6F A;  5JIY A;  3M56 A;  4J7F A;  3M55 A;  5EG2 A;  4FMU A;  3DB5 A;  4C1Q A;  2JV0 A;  4QEP A;  4QEN A;  3BO5 A;  1N3J A;  3M58 A;  4RZ0 A;  5ARG A;  4YPE A;  4J83 A;  1MT6 A;  5JJ0 A;  1XQH A;  3K5K A;  4E47 A;  3TG5 A;  4O30 A;  3OXF A;  2O8J A;  3M54 A;  1ZKK A;  3RAY A;  4JLG A;  3EP0 A;  3F9X A;  3S7D A;  5F5E A;  2R3A A;  5F6L A;  5JHN A;  4YNM A;  5TTF A;  3QWP A;  4IJ8 A;  5TEG A;  2G46 A;  5CPR B;  5LSZ A;  3OS5 A;  5AYF A;  4YPA A;  3M5A A;  4J8O A;  2RFI A;  4YND A;  5T0K A;  4JDS A;  4J7I A;  4NVQ A;  3RIB A;  4YPU A;  3PDN A;  3MO5 A;  4WUY A;  3OXL A;  4MI0 A;  1H3I A;  5HQ8 A;  3M57 A;  5KJM A;  4YNP A;  3M59 A;  5KJN A;  4Z4P A;  3RJW A;  3S7J A;  1MUF A;  3MEK A;  1PEG A;  1O9S A;  3HNA A;  5TH7 A;  5KJK A;  3IHX A;  4LDG A;  3MO0 A;  5LSX A;  1MVH A;  5F59 A;  1N6A A;  2BQZ A;  4I51 A;  3QWV A;  4NJ5 A;  4MI5 A;  2QPW A;  3KMA A;  3KMJ A;  3N71 A;  5CCL A;  4IJD A;  3VUZ A;  5CCM A;  4AU7 A;  3FPD A;  3SWC A;  5F6K C;  3F9W A;  3F9Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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