1PEGA

Structural basis for the product specificity of histone lysine methyltransferases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
293
structure length
266
Chain Sequence
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNCLCGTAKCRGYLW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the product specificity of histone lysine methyltransferases
pubmed doi rcsb
molecule tags Transferase
source organism Neurospora crassa
molecule keywords histone H3 methyltransferase DIM-5
total genus 44
structure length 266
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2003-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1pegA00
3M54A 5EG2A 3TG5A 1N6CA 3F9YA 3BO5A 4AU7A 2JV0A 4J83A 2F69A 3S8PA 1MT6A 4YNDA 3RJWA 3CBPA 2G46A 5ARFA 1O9SA 5JIYA 5AYFA 5TTFA 4IJDA 2BQZA 2W5YA 4BUPA 4J7FA 3DB5A 2IGQA 4J8OA 3OPEA 5T0MA 3EP0A 3RU0A 3SW9A 3M55A 3OXFA 5JHNA 3OS5A 4NJ5A 1PEGA 3M53A 5CCMA 3KMJA 1H3IA 5TH7A 1N6AA 5KJMA 2R3AA 3FPDA 3KMTA 4I51A 5F59A 4LDGA 3M57A 3F9ZA 5F6KC 4Z4PA 1MUFA 3F9XA 4C1QA 3QWPA 3RIBA 3TG4A 1XQHA 5TEGA 5ARGA 3VUZA 5JINA 2QPWA 1MVHA 1ZKKA 3S7BA 5EX0A 3MO2A 5HI7A 4JLGA 5EX3A 5HQ8A 3CBMA 5CCLA 3M59A 3K5KA 4YPUA 4MI5A 3S7FA 4E47A 3PDNA 3CBOA 4IJ8A 4WUYA 4JDSA 3F9WA 4YNMA 3MEKA 3N71A 3MO0A 4MI0A 3QWVA 5KJNA 1ML9A 3OXLA 5LSXA 5F6LA 4QEPA 3M56A 4O6FA 2RFIA 5KJLA 3DALA 3M5AA 2W5ZA 2O8JA 3IHXA 3SWCA 4FMUA 5F5EA 4QEOA 3OXGA 4QENA 3M58A 1N3JA 5T5GA 3S7DA 5KJKA 5T0KA 3S7JA 3MO5A 3QWWA 5CPRB 3HNAA 5JJ0A 4YPAA 1MVXA 3KMAA 3VV0A 4RZ0A 5LSZA 4NVQA 4O30A 3OOIA 4H12A 3RQ4A 3RAYA 4YPEA 4J7IA 4YNPA
chains in the Genus database with same CATH superfamily
3M54A 5EG2A 3TG5A 1N6CA 3F9YA 3BO5A 4AU7A 2JV0A 4J83A 2F69A 3S8PA 1MT6A 4YNDA 3RJWA 3CBPA 2G46A 5ARFA 1O9SA 5JIYA 5AYFA 5TTFA 4IJDA 2BQZA 2W5YA 4BUPA 4J7FA 3DB5A 2IGQA 4J8OA 3OPEA 5T0MA 3EP0A 3RU0A 3SW9A 3M55A 3OXFA 5JHNA 3OS5A 4NJ5A 1PEGA 3M53A 5CCMA 3KMJA 1H3IA 5TH7A 1N6AA 5KJMA 2R3AA 3FPDA 3KMTA 4I51A 5F59A 4LDGA 3M57A 3F9ZA 5F6KC 4Z4PA 1MUFA 3F9XA 4C1QA 3QWPA 3RIBA 3TG4A 1XQHA 5TEGA 5ARGA 3VUZA 5JINA 2QPWA 1MVHA 1ZKKA 3S7BA 5EX0A 3MO2A 5HI7A 4JLGA 5EX3A 5HQ8A 3CBMA 5CCLA 3M59A 3K5KA 4YPUA 4MI5A 3S7FA 4E47A 3PDNA 3CBOA 4IJ8A 4WUYA 4JDSA 3F9WA 4YNMA 3MEKA 3N71A 3MO0A 4MI0A 3QWVA 5KJNA 1ML9A 3OXLA 5LSXA 5F6LA 4QEPA 3M56A 4O6FA 2RFIA 5KJLA 3DALA 3M5AA 2W5ZA 2O8JA 3IHXA 3SWCA 4FMUA 5F5EA 4QEOA 3OXGA 4QENA 3M58A 1N3JA 5T5GA 3S7DA 5KJKA 5T0KA 3S7JA 3MO5A 3QWWA 5CPRB 3HNAA 5JJ0A 4YPAA 1MVXA 3KMAA 3VV0A 4RZ0A 5LSZA 4NVQA 4O30A 3OOIA 4H12A 3RQ4A 3RAYA 4YPEA 4J7IA 4YNPA
chains in the Genus database with same CATH topology
3M54A 5EG2A 3TG5A 1N6CA 3F9YA 3BO5A 4AU7A 2JV0A 4J83A 2F69A 3S8PA 1MT6A 4YNDA 3RJWA 3CBPA 2G46A 5ARFA 1O9SA 5JIYA 5AYFA 5TTFA 4IJDA 2BQZA 2W5YA 4BUPA 4J7FA 3DB5A 2IGQA 4J8OA 3OPEA 5T0MA 3EP0A 3RU0A 3SW9A 3M55A 3OXFA 5JHNA 3OS5A 4NJ5A 1PEGA 3M53A 5CCMA 3KMJA 1H3IA 5TH7A 1N6AA 5KJMA 2R3AA 3FPDA 3KMTA 4I51A 5F59A 4LDGA 3M57A 3F9ZA 5F6KC 4Z4PA 1MUFA 3F9XA 4C1QA 3QWPA 3RIBA 3TG4A 1XQHA 5TEGA 5ARGA 3VUZA 5JINA 2QPWA 1MVHA 1ZKKA 3S7BA 5EX0A 3MO2A 5HI7A 4JLGA 5EX3A 5HQ8A 3CBMA 5CCLA 3M59A 3K5KA 4YPUA 4MI5A 3S7FA 4E47A 3PDNA 3CBOA 4IJ8A 4WUYA 4JDSA 3F9WA 4YNMA 3MEKA 3N71A 3MO0A 4MI0A 3QWVA 5KJNA 1ML9A 3OXLA 5LSXA 5F6LA 4QEPA 3M56A 4O6FA 2RFIA 5KJLA 3DALA 3M5AA 2W5ZA 2O8JA 3IHXA 3SWCA 4FMUA 5F5EA 4QEOA 3OXGA 4QENA 3M58A 1N3JA 5T5GA 3S7DA 5KJKA 5T0KA 3S7JA 3MO5A 3QWWA 5CPRB 3HNAA 5JJ0A 4YPAA 1MVXA 3KMAA 3VV0A 4RZ0A 5LSZA 4NVQA 4O30A 3OOIA 4H12A 3RQ4A 3RAYA 4YPEA 4J7IA 4YNPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M54 A;  5EG2 A;  3TG5 A;  1N6C A;  3F9Y A;  3BO5 A;  4AU7 A;  2JV0 A;  4J83 A;  2F69 A;  3S8P A;  1MT6 A;  4YND A;  3RJW A;  3CBP A;  2G46 A;  5ARF A;  1O9S A;  5JIY A;  5AYF A;  5TTF A;  4IJD A;  2BQZ A;  2W5Y A;  4BUP A;  4J7F A;  3DB5 A;  2IGQ A;  4J8O A;  3OPE A;  5T0M A;  3EP0 A;  3RU0 A;  3SW9 A;  3M55 A;  3OXF A;  5JHN A;  3OS5 A;  4NJ5 A;  1PEG A;  3M53 A;  5CCM A;  3KMJ A;  1H3I A;  5TH7 A;  1N6A A;  5KJM A;  2R3A A;  3FPD A;  3KMT A;  4I51 A;  5F59 A;  4LDG A;  3M57 A;  3F9Z A;  5F6K C;  4Z4P A;  1MUF A;  3F9X A;  4C1Q A;  3QWP A;  3RIB A;  3TG4 A;  1XQH A;  5TEG A;  5ARG A;  3VUZ A;  5JIN A;  2QPW A;  1MVH A;  1ZKK A;  3S7B A;  5EX0 A;  3MO2 A;  5HI7 A;  4JLG A;  5EX3 A;  5HQ8 A;  3CBM A;  5CCL A;  3M59 A;  3K5K A;  4YPU A;  4MI5 A;  3S7F A;  4E47 A;  3PDN A;  3CBO A;  4IJ8 A;  4WUY A;  4JDS A;  3F9W A;  4YNM A;  3MEK A;  3N71 A;  3MO0 A;  4MI0 A;  3QWV A;  5KJN A;  1ML9 A;  3OXL A;  5LSX A;  5F6L A;  4QEP A;  3M56 A;  4O6F A;  2RFI A;  5KJL A;  3DAL A;  3M5A A;  2W5Z A;  2O8J A;  3IHX A;  3SWC A;  4FMU A;  5F5E A;  4QEO A;  3OXG A;  4QEN A;  3M58 A;  1N3J A;  5T5G A;  3S7D A;  5KJK A;  5T0K A;  3S7J A;  3MO5 A;  3QWW A;  5CPR B;  3HNA A;  5JJ0 A;  4YPA A;  1MVX A;  3KMA A;  3VV0 A;  4RZ0 A;  5LSZ A;  4NVQ A;  4O30 A;  3OOI A;  4H12 A;  3RQ4 A;  3RAY A;  4YPE A;  4J7I A;  4YNP A; 
#chains in the Genus database with same CATH topology
 3M54 A;  5EG2 A;  3TG5 A;  1N6C A;  3F9Y A;  3BO5 A;  4AU7 A;  2JV0 A;  4J83 A;  2F69 A;  3S8P A;  1MT6 A;  4YND A;  3RJW A;  3CBP A;  2G46 A;  5ARF A;  1O9S A;  5JIY A;  5AYF A;  5TTF A;  4IJD A;  2BQZ A;  2W5Y A;  4BUP A;  4J7F A;  3DB5 A;  2IGQ A;  4J8O A;  3OPE A;  5T0M A;  3EP0 A;  3RU0 A;  3SW9 A;  3M55 A;  3OXF A;  5JHN A;  3OS5 A;  4NJ5 A;  1PEG A;  3M53 A;  5CCM A;  3KMJ A;  1H3I A;  5TH7 A;  1N6A A;  5KJM A;  2R3A A;  3FPD A;  3KMT A;  4I51 A;  5F59 A;  4LDG A;  3M57 A;  3F9Z A;  5F6K C;  4Z4P A;  1MUF A;  3F9X A;  4C1Q A;  3QWP A;  3RIB A;  3TG4 A;  1XQH A;  5TEG A;  5ARG A;  3VUZ A;  5JIN A;  2QPW A;  1MVH A;  1ZKK A;  3S7B A;  5EX0 A;  3MO2 A;  5HI7 A;  4JLG A;  5EX3 A;  5HQ8 A;  3CBM A;  5CCL A;  3M59 A;  3K5K A;  4YPU A;  4MI5 A;  3S7F A;  4E47 A;  3PDN A;  3CBO A;  4IJ8 A;  4WUY A;  4JDS A;  3F9W A;  4YNM A;  3MEK A;  3N71 A;  3MO0 A;  4MI0 A;  3QWV A;  5KJN A;  1ML9 A;  3OXL A;  5LSX A;  5F6L A;  4QEP A;  3M56 A;  4O6F A;  2RFI A;  5KJL A;  3DAL A;  3M5A A;  2W5Z A;  2O8J A;  3IHX A;  3SWC A;  4FMU A;  5F5E A;  4QEO A;  3OXG A;  4QEN A;  3M58 A;  1N3J A;  5T5G A;  3S7D A;  5KJK A;  5T0K A;  3S7J A;  3MO5 A;  3QWW A;  5CPR B;  3HNA A;  5JJ0 A;  4YPA A;  1MVX A;  3KMA A;  3VV0 A;  4RZ0 A;  5LSZ A;  4NVQ A;  4O30 A;  3OOI A;  4H12 A;  3RQ4 A;  3RAY A;  4YPE A;  4J7I A;  4YNP A; 
#chains in the Genus database with same CATH homology
 3M54 A;  5EG2 A;  3TG5 A;  1N6C A;  3F9Y A;  3BO5 A;  4AU7 A;  2JV0 A;  4J83 A;  2F69 A;  3S8P A;  1MT6 A;  4YND A;  3RJW A;  3CBP A;  2G46 A;  5ARF A;  1O9S A;  5JIY A;  5AYF A;  5TTF A;  4IJD A;  2BQZ A;  2W5Y A;  4BUP A;  4J7F A;  3DB5 A;  2IGQ A;  4J8O A;  3OPE A;  5T0M A;  3EP0 A;  3RU0 A;  3SW9 A;  3M55 A;  3OXF A;  5JHN A;  3OS5 A;  4NJ5 A;  1PEG A;  3M53 A;  5CCM A;  3KMJ A;  1H3I A;  5TH7 A;  1N6A A;  5KJM A;  2R3A A;  3FPD A;  3KMT A;  4I51 A;  5F59 A;  4LDG A;  3M57 A;  3F9Z A;  5F6K C;  4Z4P A;  1MUF A;  3F9X A;  4C1Q A;  3QWP A;  3RIB A;  3TG4 A;  1XQH A;  5TEG A;  5ARG A;  3VUZ A;  5JIN A;  2QPW A;  1MVH A;  1ZKK A;  3S7B A;  5EX0 A;  3MO2 A;  5HI7 A;  4JLG A;  5EX3 A;  5HQ8 A;  3CBM A;  5CCL A;  3M59 A;  3K5K A;  4YPU A;  4MI5 A;  3S7F A;  4E47 A;  3PDN A;  3CBO A;  4IJ8 A;  4WUY A;  4JDS A;  3F9W A;  4YNM A;  3MEK A;  3N71 A;  3MO0 A;  4MI0 A;  3QWV A;  5KJN A;  1ML9 A;  3OXL A;  5LSX A;  5F6L A;  4QEP A;  3M56 A;  4O6F A;  2RFI A;  5KJL A;  3DAL A;  3M5A A;  2W5Z A;  2O8J A;  3IHX A;  3SWC A;  4FMU A;  5F5E A;  4QEO A;  3OXG A;  4QEN A;  3M58 A;  1N3J A;  5T5G A;  3S7D A;  5KJK A;  5T0K A;  3S7J A;  3MO5 A;  3QWW A;  5CPR B;  3HNA A;  5JJ0 A;  4YPA A;  1MVX A;  3KMA A;  3VV0 A;  4RZ0 A;  5LSZ A;  4NVQ A;  4O30 A;  3OOI A;  4H12 A;  3RQ4 A;  3RAY A;  4YPE A;  4J7I A;  4YNP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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