2W5ZA

Ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide.
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
180
structure length
180
Chain Sequence
EYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords HISTONE-LYSINE N-METHYLTRANSFERASE HRX
total genus 48
structure length 180
sequence length 180
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2w5zA01
3M54A 3S8PA 3VV0A 4YNMA 5KJKA 3VUZA 3BO5A 5AYFA 1XQHA 3N71A 5F6KC 4IJDA 4QEPA 4J8OA 3M56A 5TH7A 4JDSA 5CCLA 3RQ4A 1ML9A 3TG4A 2IGQA 3IHXA 4FMUA 3S7JA 2BQZA 5KJNA 5ARGA 5CPRB 5JINA 5HI7A 1N6CA 1MVHA 4YNPA 5CCMA 3SW9A 2W5ZA 4YNDA 3M58A 5LSXA 4QEOA 3KMJA 1MT6A 2QPWA 3CBMA 4O6FA 5TEGA 3M55A 3QWVA 4H12A 4YPAA 5F5EA 5JIYA 4AU7A 5ARFA 5T0MA 3EP0A 3M53A 4MI5A 3S7DA 4WUYA 4C1QA 5F6LA 3M59A 2RFIA 5T0KA 3S7FA 3PDNA 4Z4PA 5KJLA 4BUPA 5EX3A 1PEGA 2G46A 4J7IA 5EG2A 3K5KA 4YPEA 3HNAA 3M57A 4IJ8A 3RJWA 2W5YA 3RAYA 3RIBA 3MEKA 3OXGA 3F9XA 4O30A 5KJMA 1N3JA 3OXLA 1O9SA 1H3IA 4LDGA 3F9WA 3OPEA 2F69A 3OOIA 5JJ0A 5LSZA 3QWPA 3M5AA 5TTFA 3CBOA 4NJ5A 3OXFA 3TG5A 5JHNA 3KMAA 4I51A 3S7BA 1MUFA 2O8JA 1N6AA 3DB5A 3RU0A 5EX0A 4QENA 3F9ZA 4NVQA 3MO0A 4E47A 3CBPA 5F59A 4J83A 4MI0A 3MO5A 4J7FA 4RZ0A 3DALA 1ZKKA 3KMTA 3OS5A 3SWCA 3FPDA 5T5GA 4JLGA 3MO2A 2JV0A 1MVXA 3QWWA 4YPUA 2R3AA 5HQ8A 3F9YA
chains in the Genus database with same CATH superfamily
3M54A 3S8PA 3VV0A 4YNMA 5KJKA 3VUZA 3BO5A 5AYFA 1XQHA 3N71A 5F6KC 4IJDA 4QEPA 4J8OA 3M56A 5TH7A 4JDSA 5CCLA 3RQ4A 1ML9A 3TG4A 2IGQA 3IHXA 4FMUA 3S7JA 2BQZA 5KJNA 5ARGA 5CPRB 5JINA 5HI7A 1N6CA 1MVHA 4YNPA 5CCMA 3SW9A 2W5ZA 4YNDA 3M58A 5LSXA 4QEOA 3KMJA 1MT6A 2QPWA 3CBMA 4O6FA 5TEGA 3M55A 3QWVA 4H12A 4YPAA 5F5EA 5JIYA 4AU7A 5ARFA 5T0MA 3EP0A 3M53A 4MI5A 3S7DA 4WUYA 4C1QA 5F6LA 3M59A 2RFIA 5T0KA 3S7FA 3PDNA 4Z4PA 5KJLA 4BUPA 5EX3A 1PEGA 2G46A 4J7IA 5EG2A 3K5KA 4YPEA 3HNAA 3M57A 4IJ8A 3RJWA 2W5YA 3RAYA 3RIBA 3MEKA 3OXGA 3F9XA 4O30A 5KJMA 1N3JA 3OXLA 1O9SA 1H3IA 4LDGA 3F9WA 3OPEA 2F69A 3OOIA 5JJ0A 5LSZA 3QWPA 3M5AA 5TTFA 3CBOA 4NJ5A 3OXFA 3TG5A 5JHNA 3KMAA 4I51A 3S7BA 1MUFA 2O8JA 1N6AA 3DB5A 3RU0A 5EX0A 4QENA 3F9ZA 4NVQA 3MO0A 4E47A 3CBPA 5F59A 4J83A 4MI0A 3MO5A 4J7FA 4RZ0A 3DALA 1ZKKA 3KMTA 3OS5A 3SWCA 3FPDA 5T5GA 4JLGA 3MO2A 2JV0A 1MVXA 3QWWA 4YPUA 2R3AA 5HQ8A 3F9YA
chains in the Genus database with same CATH topology
3M54A 3S8PA 3VV0A 4YNMA 5KJKA 3VUZA 3BO5A 5AYFA 1XQHA 3N71A 5F6KC 4IJDA 4QEPA 4J8OA 3M56A 5TH7A 4JDSA 5CCLA 3RQ4A 1ML9A 3TG4A 2IGQA 3IHXA 4FMUA 3S7JA 2BQZA 5KJNA 5ARGA 5CPRB 5JINA 5HI7A 1N6CA 1MVHA 4YNPA 5CCMA 3SW9A 2W5ZA 4YNDA 3M58A 5LSXA 4QEOA 3KMJA 1MT6A 2QPWA 3CBMA 4O6FA 5TEGA 3M55A 3QWVA 4H12A 4YPAA 5F5EA 5JIYA 4AU7A 5ARFA 5T0MA 3EP0A 3M53A 4MI5A 3S7DA 4WUYA 4C1QA 5F6LA 3M59A 2RFIA 5T0KA 3S7FA 3PDNA 4Z4PA 5KJLA 4BUPA 5EX3A 1PEGA 2G46A 4J7IA 5EG2A 3K5KA 4YPEA 3HNAA 3M57A 4IJ8A 3RJWA 2W5YA 3RAYA 3RIBA 3MEKA 3OXGA 3F9XA 4O30A 5KJMA 1N3JA 3OXLA 1O9SA 1H3IA 4LDGA 3F9WA 3OPEA 2F69A 3OOIA 5JJ0A 5LSZA 3QWPA 3M5AA 5TTFA 3CBOA 4NJ5A 3OXFA 3TG5A 5JHNA 3KMAA 4I51A 3S7BA 1MUFA 2O8JA 1N6AA 3DB5A 3RU0A 5EX0A 4QENA 3F9ZA 4NVQA 3MO0A 4E47A 3CBPA 5F59A 4J83A 4MI0A 3MO5A 4J7FA 4RZ0A 3DALA 1ZKKA 3KMTA 3OS5A 3SWCA 3FPDA 5T5GA 4JLGA 3MO2A 2JV0A 1MVXA 3QWWA 4YPUA 2R3AA 5HQ8A 3F9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M54 A;  3S8P A;  3VV0 A;  4YNM A;  5KJK A;  3VUZ A;  3BO5 A;  5AYF A;  1XQH A;  3N71 A;  5F6K C;  4IJD A;  4QEP A;  4J8O A;  3M56 A;  5TH7 A;  4JDS A;  5CCL A;  3RQ4 A;  1ML9 A;  3TG4 A;  2IGQ A;  3IHX A;  4FMU A;  3S7J A;  2BQZ A;  5KJN A;  5ARG A;  5CPR B;  5JIN A;  5HI7 A;  1N6C A;  1MVH A;  4YNP A;  5CCM A;  3SW9 A;  2W5Z A;  4YND A;  3M58 A;  5LSX A;  4QEO A;  3KMJ A;  1MT6 A;  2QPW A;  3CBM A;  4O6F A;  5TEG A;  3M55 A;  3QWV A;  4H12 A;  4YPA A;  5F5E A;  5JIY A;  4AU7 A;  5ARF A;  5T0M A;  3EP0 A;  3M53 A;  4MI5 A;  3S7D A;  4WUY A;  4C1Q A;  5F6L A;  3M59 A;  2RFI A;  5T0K A;  3S7F A;  3PDN A;  4Z4P A;  5KJL A;  4BUP A;  5EX3 A;  1PEG A;  2G46 A;  4J7I A;  5EG2 A;  3K5K A;  4YPE A;  3HNA A;  3M57 A;  4IJ8 A;  3RJW A;  2W5Y A;  3RAY A;  3RIB A;  3MEK A;  3OXG A;  3F9X A;  4O30 A;  5KJM A;  1N3J A;  3OXL A;  1O9S A;  1H3I A;  4LDG A;  3F9W A;  3OPE A;  2F69 A;  3OOI A;  5JJ0 A;  5LSZ A;  3QWP A;  3M5A A;  5TTF A;  3CBO A;  4NJ5 A;  3OXF A;  3TG5 A;  5JHN A;  3KMA A;  4I51 A;  3S7B A;  1MUF A;  2O8J A;  1N6A A;  3DB5 A;  3RU0 A;  5EX0 A;  4QEN A;  3F9Z A;  4NVQ A;  3MO0 A;  4E47 A;  3CBP A;  5F59 A;  4J83 A;  4MI0 A;  3MO5 A;  4J7F A;  4RZ0 A;  3DAL A;  1ZKK A;  3KMT A;  3OS5 A;  3SWC A;  3FPD A;  5T5G A;  4JLG A;  3MO2 A;  2JV0 A;  1MVX A;  3QWW A;  4YPU A;  2R3A A;  5HQ8 A;  3F9Y A; 
#chains in the Genus database with same CATH topology
 3M54 A;  3S8P A;  3VV0 A;  4YNM A;  5KJK A;  3VUZ A;  3BO5 A;  5AYF A;  1XQH A;  3N71 A;  5F6K C;  4IJD A;  4QEP A;  4J8O A;  3M56 A;  5TH7 A;  4JDS A;  5CCL A;  3RQ4 A;  1ML9 A;  3TG4 A;  2IGQ A;  3IHX A;  4FMU A;  3S7J A;  2BQZ A;  5KJN A;  5ARG A;  5CPR B;  5JIN A;  5HI7 A;  1N6C A;  1MVH A;  4YNP A;  5CCM A;  3SW9 A;  2W5Z A;  4YND A;  3M58 A;  5LSX A;  4QEO A;  3KMJ A;  1MT6 A;  2QPW A;  3CBM A;  4O6F A;  5TEG A;  3M55 A;  3QWV A;  4H12 A;  4YPA A;  5F5E A;  5JIY A;  4AU7 A;  5ARF A;  5T0M A;  3EP0 A;  3M53 A;  4MI5 A;  3S7D A;  4WUY A;  4C1Q A;  5F6L A;  3M59 A;  2RFI A;  5T0K A;  3S7F A;  3PDN A;  4Z4P A;  5KJL A;  4BUP A;  5EX3 A;  1PEG A;  2G46 A;  4J7I A;  5EG2 A;  3K5K A;  4YPE A;  3HNA A;  3M57 A;  4IJ8 A;  3RJW A;  2W5Y A;  3RAY A;  3RIB A;  3MEK A;  3OXG A;  3F9X A;  4O30 A;  5KJM A;  1N3J A;  3OXL A;  1O9S A;  1H3I A;  4LDG A;  3F9W A;  3OPE A;  2F69 A;  3OOI A;  5JJ0 A;  5LSZ A;  3QWP A;  3M5A A;  5TTF A;  3CBO A;  4NJ5 A;  3OXF A;  3TG5 A;  5JHN A;  3KMA A;  4I51 A;  3S7B A;  1MUF A;  2O8J A;  1N6A A;  3DB5 A;  3RU0 A;  5EX0 A;  4QEN A;  3F9Z A;  4NVQ A;  3MO0 A;  4E47 A;  3CBP A;  5F59 A;  4J83 A;  4MI0 A;  3MO5 A;  4J7F A;  4RZ0 A;  3DAL A;  1ZKK A;  3KMT A;  3OS5 A;  3SWC A;  3FPD A;  5T5G A;  4JLG A;  3MO2 A;  2JV0 A;  1MVX A;  3QWW A;  4YPU A;  2R3A A;  5HQ8 A;  3F9Y A; 
#chains in the Genus database with same CATH homology
 3M54 A;  3S8P A;  3VV0 A;  4YNM A;  5KJK A;  3VUZ A;  3BO5 A;  5AYF A;  1XQH A;  3N71 A;  5F6K C;  4IJD A;  4QEP A;  4J8O A;  3M56 A;  5TH7 A;  4JDS A;  5CCL A;  3RQ4 A;  1ML9 A;  3TG4 A;  2IGQ A;  3IHX A;  4FMU A;  3S7J A;  2BQZ A;  5KJN A;  5ARG A;  5CPR B;  5JIN A;  5HI7 A;  1N6C A;  1MVH A;  4YNP A;  5CCM A;  3SW9 A;  2W5Z A;  4YND A;  3M58 A;  5LSX A;  4QEO A;  3KMJ A;  1MT6 A;  2QPW A;  3CBM A;  4O6F A;  5TEG A;  3M55 A;  3QWV A;  4H12 A;  4YPA A;  5F5E A;  5JIY A;  4AU7 A;  5ARF A;  5T0M A;  3EP0 A;  3M53 A;  4MI5 A;  3S7D A;  4WUY A;  4C1Q A;  5F6L A;  3M59 A;  2RFI A;  5T0K A;  3S7F A;  3PDN A;  4Z4P A;  5KJL A;  4BUP A;  5EX3 A;  1PEG A;  2G46 A;  4J7I A;  5EG2 A;  3K5K A;  4YPE A;  3HNA A;  3M57 A;  4IJ8 A;  3RJW A;  2W5Y A;  3RAY A;  3RIB A;  3MEK A;  3OXG A;  3F9X A;  4O30 A;  5KJM A;  1N3J A;  3OXL A;  1O9S A;  1H3I A;  4LDG A;  3F9W A;  3OPE A;  2F69 A;  3OOI A;  5JJ0 A;  5LSZ A;  3QWP A;  3M5A A;  5TTF A;  3CBO A;  4NJ5 A;  3OXF A;  3TG5 A;  5JHN A;  3KMA A;  4I51 A;  3S7B A;  1MUF A;  2O8J A;  1N6A A;  3DB5 A;  3RU0 A;  5EX0 A;  4QEN A;  3F9Z A;  4NVQ A;  3MO0 A;  4E47 A;  3CBP A;  5F59 A;  4J83 A;  4MI0 A;  3MO5 A;  4J7F A;  4RZ0 A;  3DAL A;  1ZKK A;  3KMT A;  3OS5 A;  3SWC A;  3FPD A;  5T5G A;  4JLG A;  3MO2 A;  2JV0 A;  1MVX A;  3QWW A;  4YPU A;  2R3A A;  5HQ8 A;  3F9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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