2BQZA

Crystal structure of a ternary complex of the human histone methyltransferase pr-set7 (also known as set8)
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
161
structure length
161
Chain Sequence
RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords SET8 PROTEIN
total genus 44
structure length 161
sequence length 161
chains with identical sequence E
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2005-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2bqzA00
1H3IA 4WUYA 1ML9A 3RIBA 3SWCA 3OXLA 5CPRB 3QWVA 2BQZA 5T5GA 3DALA 4H12A 3SW9A 3VUZA 4J7FA 4JDSA 4RZ0A 5EX3A 3VV0A 3KMJA 3M53A 3M55A 2RFIA 5JJ0A 4MI0A 4FMUA 4BUPA 4J8OA 1N6AA 4C1QA 3RQ4A 3QWWA 2W5YA 4NJ5A 5AYFA 3MO0A 4IJ8A 5JIYA 5JINA 3M54A 4O30A 3OXFA 4AU7A 3BO5A 5JHNA 3TG5A 4QENA 4JLGA 4LDGA 3F9YA 5TH7A 3KMTA 3M5AA 4IJDA 3OXGA 5KJMA 4Z4PA 1XQHA 4YPAA 5F6LA 1MT6A 3S7DA 4YNPA 1MUFA 3RU0A 3TG4A 2IGQA 1O9SA 1MVXA 3S7JA 1N3JA 3MEKA 2R3AA 4O6FA 1N6CA 3S7BA 1ZKKA 2QPWA 5EX0A 5HI7A 3F9XA 2JV0A 3RAYA 2O8JA 4I51A 3KMAA 3PDNA 4QEPA 4QEOA 5CCMA 5KJKA 3CBPA 1PEGA 4YNDA 4YPEA 3EP0A 3HNAA 3IHXA 5T0KA 5ARFA 3M57A 4J83A 5EG2A 3CBOA 5KJNA 3F9WA 5F6KC 4J7IA 1MVHA 4NVQA 2G46A 4YNMA 5CCLA 5LSZA 2W5ZA 3OPEA 3FPDA 3MO2A 5TTFA 3QWPA 3M56A 3F9ZA 5F5EA 3K5KA 5F59A 2F69A 3MO5A 3DB5A 5LSXA 3N71A 4MI5A 5TEGA 5HQ8A 3OOIA 3M59A 4E47A 3S7FA 3S8PA 3M58A 5ARGA 4YPUA 5T0MA 5KJLA 3CBMA 3OS5A 3RJWA
chains in the Genus database with same CATH superfamily
1H3IA 4WUYA 1ML9A 3RIBA 3SWCA 3OXLA 5CPRB 3QWVA 2BQZA 5T5GA 3DALA 4H12A 3SW9A 3VUZA 4J7FA 4JDSA 4RZ0A 5EX3A 3VV0A 3KMJA 3M53A 3M55A 2RFIA 5JJ0A 4MI0A 4FMUA 4BUPA 4J8OA 1N6AA 4C1QA 3RQ4A 3QWWA 2W5YA 4NJ5A 5AYFA 3MO0A 4IJ8A 5JIYA 5JINA 3M54A 4O30A 3OXFA 4AU7A 3BO5A 5JHNA 3TG5A 4QENA 4JLGA 4LDGA 3F9YA 5TH7A 3KMTA 3M5AA 4IJDA 3OXGA 5KJMA 4Z4PA 1XQHA 4YPAA 5F6LA 1MT6A 3S7DA 4YNPA 1MUFA 3RU0A 3TG4A 2IGQA 1O9SA 1MVXA 3S7JA 1N3JA 3MEKA 2R3AA 4O6FA 1N6CA 3S7BA 1ZKKA 2QPWA 5EX0A 5HI7A 3F9XA 2JV0A 3RAYA 2O8JA 4I51A 3KMAA 3PDNA 4QEPA 4QEOA 5CCMA 5KJKA 3CBPA 1PEGA 4YNDA 4YPEA 3EP0A 3HNAA 3IHXA 5T0KA 5ARFA 3M57A 4J83A 5EG2A 3CBOA 5KJNA 3F9WA 5F6KC 4J7IA 1MVHA 4NVQA 2G46A 4YNMA 5CCLA 5LSZA 2W5ZA 3OPEA 3FPDA 3MO2A 5TTFA 3QWPA 3M56A 3F9ZA 5F5EA 3K5KA 5F59A 2F69A 3MO5A 3DB5A 5LSXA 3N71A 4MI5A 5TEGA 5HQ8A 3OOIA 3M59A 4E47A 3S7FA 3S8PA 3M58A 5ARGA 4YPUA 5T0MA 5KJLA 3CBMA 3OS5A 3RJWA
chains in the Genus database with same CATH topology
1H3IA 4WUYA 1ML9A 3RIBA 3SWCA 3OXLA 5CPRB 3QWVA 2BQZA 5T5GA 3DALA 4H12A 3SW9A 3VUZA 4J7FA 4JDSA 4RZ0A 5EX3A 3VV0A 3KMJA 3M53A 3M55A 2RFIA 5JJ0A 4MI0A 4FMUA 4BUPA 4J8OA 1N6AA 4C1QA 3RQ4A 3QWWA 2W5YA 4NJ5A 5AYFA 3MO0A 4IJ8A 5JIYA 5JINA 3M54A 4O30A 3OXFA 4AU7A 3BO5A 5JHNA 3TG5A 4QENA 4JLGA 4LDGA 3F9YA 5TH7A 3KMTA 3M5AA 4IJDA 3OXGA 5KJMA 4Z4PA 1XQHA 4YPAA 5F6LA 1MT6A 3S7DA 4YNPA 1MUFA 3RU0A 3TG4A 2IGQA 1O9SA 1MVXA 3S7JA 1N3JA 3MEKA 2R3AA 4O6FA 1N6CA 3S7BA 1ZKKA 2QPWA 5EX0A 5HI7A 3F9XA 2JV0A 3RAYA 2O8JA 4I51A 3KMAA 3PDNA 4QEPA 4QEOA 5CCMA 5KJKA 3CBPA 1PEGA 4YNDA 4YPEA 3EP0A 3HNAA 3IHXA 5T0KA 5ARFA 3M57A 4J83A 5EG2A 3CBOA 5KJNA 3F9WA 5F6KC 4J7IA 1MVHA 4NVQA 2G46A 4YNMA 5CCLA 5LSZA 2W5ZA 3OPEA 3FPDA 3MO2A 5TTFA 3QWPA 3M56A 3F9ZA 5F5EA 3K5KA 5F59A 2F69A 3MO5A 3DB5A 5LSXA 3N71A 4MI5A 5TEGA 5HQ8A 3OOIA 3M59A 4E47A 3S7FA 3S8PA 3M58A 5ARGA 4YPUA 5T0MA 5KJLA 3CBMA 3OS5A 3RJWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H3I A;  4WUY A;  1ML9 A;  3RIB A;  3SWC A;  3OXL A;  5CPR B;  3QWV A;  2BQZ A;  5T5G A;  3DAL A;  4H12 A;  3SW9 A;  3VUZ A;  4J7F A;  4JDS A;  4RZ0 A;  5EX3 A;  3VV0 A;  3KMJ A;  3M53 A;  3M55 A;  2RFI A;  5JJ0 A;  4MI0 A;  4FMU A;  4BUP A;  4J8O A;  1N6A A;  4C1Q A;  3RQ4 A;  3QWW A;  2W5Y A;  4NJ5 A;  5AYF A;  3MO0 A;  4IJ8 A;  5JIY A;  5JIN A;  3M54 A;  4O30 A;  3OXF A;  4AU7 A;  3BO5 A;  5JHN A;  3TG5 A;  4QEN A;  4JLG A;  4LDG A;  3F9Y A;  5TH7 A;  3KMT A;  3M5A A;  4IJD A;  3OXG A;  5KJM A;  4Z4P A;  1XQH A;  4YPA A;  5F6L A;  1MT6 A;  3S7D A;  4YNP A;  1MUF A;  3RU0 A;  3TG4 A;  2IGQ A;  1O9S A;  1MVX A;  3S7J A;  1N3J A;  3MEK A;  2R3A A;  4O6F A;  1N6C A;  3S7B A;  1ZKK A;  2QPW A;  5EX0 A;  5HI7 A;  3F9X A;  2JV0 A;  3RAY A;  2O8J A;  4I51 A;  3KMA A;  3PDN A;  4QEP A;  4QEO A;  5CCM A;  5KJK A;  3CBP A;  1PEG A;  4YND A;  4YPE A;  3EP0 A;  3HNA A;  3IHX A;  5T0K A;  5ARF A;  3M57 A;  4J83 A;  5EG2 A;  3CBO A;  5KJN A;  3F9W A;  5F6K C;  4J7I A;  1MVH A;  4NVQ A;  2G46 A;  4YNM A;  5CCL A;  5LSZ A;  2W5Z A;  3OPE A;  3FPD A;  3MO2 A;  5TTF A;  3QWP A;  3M56 A;  3F9Z A;  5F5E A;  3K5K A;  5F59 A;  2F69 A;  3MO5 A;  3DB5 A;  5LSX A;  3N71 A;  4MI5 A;  5TEG A;  5HQ8 A;  3OOI A;  3M59 A;  4E47 A;  3S7F A;  3S8P A;  3M58 A;  5ARG A;  4YPU A;  5T0M A;  5KJL A;  3CBM A;  3OS5 A;  3RJW A; 
#chains in the Genus database with same CATH topology
 1H3I A;  4WUY A;  1ML9 A;  3RIB A;  3SWC A;  3OXL A;  5CPR B;  3QWV A;  2BQZ A;  5T5G A;  3DAL A;  4H12 A;  3SW9 A;  3VUZ A;  4J7F A;  4JDS A;  4RZ0 A;  5EX3 A;  3VV0 A;  3KMJ A;  3M53 A;  3M55 A;  2RFI A;  5JJ0 A;  4MI0 A;  4FMU A;  4BUP A;  4J8O A;  1N6A A;  4C1Q A;  3RQ4 A;  3QWW A;  2W5Y A;  4NJ5 A;  5AYF A;  3MO0 A;  4IJ8 A;  5JIY A;  5JIN A;  3M54 A;  4O30 A;  3OXF A;  4AU7 A;  3BO5 A;  5JHN A;  3TG5 A;  4QEN A;  4JLG A;  4LDG A;  3F9Y A;  5TH7 A;  3KMT A;  3M5A A;  4IJD A;  3OXG A;  5KJM A;  4Z4P A;  1XQH A;  4YPA A;  5F6L A;  1MT6 A;  3S7D A;  4YNP A;  1MUF A;  3RU0 A;  3TG4 A;  2IGQ A;  1O9S A;  1MVX A;  3S7J A;  1N3J A;  3MEK A;  2R3A A;  4O6F A;  1N6C A;  3S7B A;  1ZKK A;  2QPW A;  5EX0 A;  5HI7 A;  3F9X A;  2JV0 A;  3RAY A;  2O8J A;  4I51 A;  3KMA A;  3PDN A;  4QEP A;  4QEO A;  5CCM A;  5KJK A;  3CBP A;  1PEG A;  4YND A;  4YPE A;  3EP0 A;  3HNA A;  3IHX A;  5T0K A;  5ARF A;  3M57 A;  4J83 A;  5EG2 A;  3CBO A;  5KJN A;  3F9W A;  5F6K C;  4J7I A;  1MVH A;  4NVQ A;  2G46 A;  4YNM A;  5CCL A;  5LSZ A;  2W5Z A;  3OPE A;  3FPD A;  3MO2 A;  5TTF A;  3QWP A;  3M56 A;  3F9Z A;  5F5E A;  3K5K A;  5F59 A;  2F69 A;  3MO5 A;  3DB5 A;  5LSX A;  3N71 A;  4MI5 A;  5TEG A;  5HQ8 A;  3OOI A;  3M59 A;  4E47 A;  3S7F A;  3S8P A;  3M58 A;  5ARG A;  4YPU A;  5T0M A;  5KJL A;  3CBM A;  3OS5 A;  3RJW A; 
#chains in the Genus database with same CATH homology
 1H3I A;  4WUY A;  1ML9 A;  3RIB A;  3SWC A;  3OXL A;  5CPR B;  3QWV A;  2BQZ A;  5T5G A;  3DAL A;  4H12 A;  3SW9 A;  3VUZ A;  4J7F A;  4JDS A;  4RZ0 A;  5EX3 A;  3VV0 A;  3KMJ A;  3M53 A;  3M55 A;  2RFI A;  5JJ0 A;  4MI0 A;  4FMU A;  4BUP A;  4J8O A;  1N6A A;  4C1Q A;  3RQ4 A;  3QWW A;  2W5Y A;  4NJ5 A;  5AYF A;  3MO0 A;  4IJ8 A;  5JIY A;  5JIN A;  3M54 A;  4O30 A;  3OXF A;  4AU7 A;  3BO5 A;  5JHN A;  3TG5 A;  4QEN A;  4JLG A;  4LDG A;  3F9Y A;  5TH7 A;  3KMT A;  3M5A A;  4IJD A;  3OXG A;  5KJM A;  4Z4P A;  1XQH A;  4YPA A;  5F6L A;  1MT6 A;  3S7D A;  4YNP A;  1MUF A;  3RU0 A;  3TG4 A;  2IGQ A;  1O9S A;  1MVX A;  3S7J A;  1N3J A;  3MEK A;  2R3A A;  4O6F A;  1N6C A;  3S7B A;  1ZKK A;  2QPW A;  5EX0 A;  5HI7 A;  3F9X A;  2JV0 A;  3RAY A;  2O8J A;  4I51 A;  3KMA A;  3PDN A;  4QEP A;  4QEO A;  5CCM A;  5KJK A;  3CBP A;  1PEG A;  4YND A;  4YPE A;  3EP0 A;  3HNA A;  3IHX A;  5T0K A;  5ARF A;  3M57 A;  4J83 A;  5EG2 A;  3CBO A;  5KJN A;  3F9W A;  5F6K C;  4J7I A;  1MVH A;  4NVQ A;  2G46 A;  4YNM A;  5CCL A;  5LSZ A;  2W5Z A;  3OPE A;  3FPD A;  3MO2 A;  5TTF A;  3QWP A;  3M56 A;  3F9Z A;  5F5E A;  3K5K A;  5F59 A;  2F69 A;  3MO5 A;  3DB5 A;  5LSX A;  3N71 A;  4MI5 A;  5TEG A;  5HQ8 A;  3OOI A;  3M59 A;  4E47 A;  3S7F A;  3S8P A;  3M58 A;  5ARG A;  4YPU A;  5T0M A;  5KJL A;  3CBM A;  3OS5 A;  3RJW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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