2RFIA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 64
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2007-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2rfiA00
1ZKKA 3OXFA 5F59A 1PEGA 1H3IA 2QPWA 1MT6A 3RAYA 4J83A 3M54A 5TEGA 4YPUA 3S8PA 3RU0A 1N6CA 4E47A 5TH7A 5CCLA 3FPDA 4J7FA 2W5ZA 3F9XA 3VUZA 4YNDA 3OXLA 4QEPA 3RQ4A 5JIYA 5KJLA 5F6KC 1N6AA 4LDGA 4O6FA 5LSZA 4JLGA 3RJWA 2BQZA 4YPAA 3PDNA 5T0MA 3DB5A 3OPEA 3MEKA 4WUYA 1ML9A 5EX3A 3TG5A 4MI5A 5CPRB 4I51A 5TTFA 4J7IA 3F9WA 3SWCA 3F9YA 2RFIA 4QENA 2W5YA 5JJ0A 3M55A 4YPEA 3KMAA 1MUFA 3HNAA 4JDSA 5ARFA 4H12A 3RIBA 3BO5A 1N3JA 4MI0A 3KMTA 5CCMA 3TG4A 3QWVA 5KJNA 4YNPA 3QWWA 4IJ8A 5T0KA 1O9SA 3K5KA 2IGQA 5AYFA 4IJDA 5JHNA 3S7FA 4J8OA 3M59A 3CBOA 5EX0A 4RZ0A 3F9ZA 3M57A 5EG2A 2R3AA 3OOIA 5T5GA 2G46A 3M53A 4O30A 5HQ8A 4NVQA 3MO0A 3S7BA 4C1QA 3OXGA 3MO2A 3S7DA 5HI7A 3CBPA 2O8JA 3EP0A 3MO5A 3KMJA 3VV0A 3M5AA 3M56A 5KJKA 3QWPA 4Z4PA 5KJMA 3SW9A 5LSXA 2F69A 5F6LA 5F5EA 4AU7A 1MVXA 4FMUA 1XQHA 4NJ5A 3IHXA 3N71A 3M58A 3OS5A 3DALA 5JINA 4YNMA 3CBMA 3S7JA 4BUPA 4QEOA 2JV0A 1MVHA 5ARGA
chains in the Genus database with same CATH superfamily
1ZKKA 3OXFA 5F59A 1PEGA 1H3IA 2QPWA 1MT6A 3RAYA 4J83A 3M54A 5TEGA 4YPUA 3S8PA 3RU0A 1N6CA 4E47A 5TH7A 5CCLA 3FPDA 4J7FA 2W5ZA 3F9XA 3VUZA 4YNDA 3OXLA 4QEPA 3RQ4A 5JIYA 5KJLA 5F6KC 1N6AA 4LDGA 4O6FA 5LSZA 4JLGA 3RJWA 2BQZA 4YPAA 3PDNA 5T0MA 3DB5A 3OPEA 3MEKA 4WUYA 1ML9A 5EX3A 3TG5A 4MI5A 5CPRB 4I51A 5TTFA 4J7IA 3F9WA 3SWCA 3F9YA 2RFIA 4QENA 2W5YA 5JJ0A 3M55A 4YPEA 3KMAA 1MUFA 3HNAA 4JDSA 5ARFA 4H12A 3RIBA 3BO5A 1N3JA 4MI0A 3KMTA 5CCMA 3TG4A 3QWVA 5KJNA 4YNPA 3QWWA 4IJ8A 5T0KA 1O9SA 3K5KA 2IGQA 5AYFA 4IJDA 5JHNA 3S7FA 4J8OA 3M59A 3CBOA 5EX0A 4RZ0A 3F9ZA 3M57A 5EG2A 2R3AA 3OOIA 5T5GA 2G46A 3M53A 4O30A 5HQ8A 4NVQA 3MO0A 3S7BA 4C1QA 3OXGA 3MO2A 3S7DA 5HI7A 3CBPA 2O8JA 3EP0A 3MO5A 3KMJA 3VV0A 3M5AA 3M56A 5KJKA 3QWPA 4Z4PA 5KJMA 3SW9A 5LSXA 2F69A 5F6LA 5F5EA 4AU7A 1MVXA 4FMUA 1XQHA 4NJ5A 3IHXA 3N71A 3M58A 3OS5A 3DALA 5JINA 4YNMA 3CBMA 3S7JA 4BUPA 4QEOA 2JV0A 1MVHA 5ARGA
chains in the Genus database with same CATH topology
1ZKKA 3OXFA 5F59A 1PEGA 1H3IA 2QPWA 1MT6A 3RAYA 4J83A 3M54A 5TEGA 4YPUA 3S8PA 3RU0A 1N6CA 4E47A 5TH7A 5CCLA 3FPDA 4J7FA 2W5ZA 3F9XA 3VUZA 4YNDA 3OXLA 4QEPA 3RQ4A 5JIYA 5KJLA 5F6KC 1N6AA 4LDGA 4O6FA 5LSZA 4JLGA 3RJWA 2BQZA 4YPAA 3PDNA 5T0MA 3DB5A 3OPEA 3MEKA 4WUYA 1ML9A 5EX3A 3TG5A 4MI5A 5CPRB 4I51A 5TTFA 4J7IA 3F9WA 3SWCA 3F9YA 2RFIA 4QENA 2W5YA 5JJ0A 3M55A 4YPEA 3KMAA 1MUFA 3HNAA 4JDSA 5ARFA 4H12A 3RIBA 3BO5A 1N3JA 4MI0A 3KMTA 5CCMA 3TG4A 3QWVA 5KJNA 4YNPA 3QWWA 4IJ8A 5T0KA 1O9SA 3K5KA 2IGQA 5AYFA 4IJDA 5JHNA 3S7FA 4J8OA 3M59A 3CBOA 5EX0A 4RZ0A 3F9ZA 3M57A 5EG2A 2R3AA 3OOIA 5T5GA 2G46A 3M53A 4O30A 5HQ8A 4NVQA 3MO0A 3S7BA 4C1QA 3OXGA 3MO2A 3S7DA 5HI7A 3CBPA 2O8JA 3EP0A 3MO5A 3KMJA 3VV0A 3M5AA 3M56A 5KJKA 3QWPA 4Z4PA 5KJMA 3SW9A 5LSXA 2F69A 5F6LA 5F5EA 4AU7A 1MVXA 4FMUA 1XQHA 4NJ5A 3IHXA 3N71A 3M58A 3OS5A 3DALA 5JINA 4YNMA 3CBMA 3S7JA 4BUPA 4QEOA 2JV0A 1MVHA 5ARGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZKK A;  3OXF A;  5F59 A;  1PEG A;  1H3I A;  2QPW A;  1MT6 A;  3RAY A;  4J83 A;  3M54 A;  5TEG A;  4YPU A;  3S8P A;  3RU0 A;  1N6C A;  4E47 A;  5TH7 A;  5CCL A;  3FPD A;  4J7F A;  2W5Z A;  3F9X A;  3VUZ A;  4YND A;  3OXL A;  4QEP A;  3RQ4 A;  5JIY A;  5KJL A;  5F6K C;  1N6A A;  4LDG A;  4O6F A;  5LSZ A;  4JLG A;  3RJW A;  2BQZ A;  4YPA A;  3PDN A;  5T0M A;  3DB5 A;  3OPE A;  3MEK A;  4WUY A;  1ML9 A;  5EX3 A;  3TG5 A;  4MI5 A;  5CPR B;  4I51 A;  5TTF A;  4J7I A;  3F9W A;  3SWC A;  3F9Y A;  2RFI A;  4QEN A;  2W5Y A;  5JJ0 A;  3M55 A;  4YPE A;  3KMA A;  1MUF A;  3HNA A;  4JDS A;  5ARF A;  4H12 A;  3RIB A;  3BO5 A;  1N3J A;  4MI0 A;  3KMT A;  5CCM A;  3TG4 A;  3QWV A;  5KJN A;  4YNP A;  3QWW A;  4IJ8 A;  5T0K A;  1O9S A;  3K5K A;  2IGQ A;  5AYF A;  4IJD A;  5JHN A;  3S7F A;  4J8O A;  3M59 A;  3CBO A;  5EX0 A;  4RZ0 A;  3F9Z A;  3M57 A;  5EG2 A;  2R3A A;  3OOI A;  5T5G A;  2G46 A;  3M53 A;  4O30 A;  5HQ8 A;  4NVQ A;  3MO0 A;  3S7B A;  4C1Q A;  3OXG A;  3MO2 A;  3S7D A;  5HI7 A;  3CBP A;  2O8J A;  3EP0 A;  3MO5 A;  3KMJ A;  3VV0 A;  3M5A A;  3M56 A;  5KJK A;  3QWP A;  4Z4P A;  5KJM A;  3SW9 A;  5LSX A;  2F69 A;  5F6L A;  5F5E A;  4AU7 A;  1MVX A;  4FMU A;  1XQH A;  4NJ5 A;  3IHX A;  3N71 A;  3M58 A;  3OS5 A;  3DAL A;  5JIN A;  4YNM A;  3CBM A;  3S7J A;  4BUP A;  4QEO A;  2JV0 A;  1MVH A;  5ARG A; 
#chains in the Genus database with same CATH topology
 1ZKK A;  3OXF A;  5F59 A;  1PEG A;  1H3I A;  2QPW A;  1MT6 A;  3RAY A;  4J83 A;  3M54 A;  5TEG A;  4YPU A;  3S8P A;  3RU0 A;  1N6C A;  4E47 A;  5TH7 A;  5CCL A;  3FPD A;  4J7F A;  2W5Z A;  3F9X A;  3VUZ A;  4YND A;  3OXL A;  4QEP A;  3RQ4 A;  5JIY A;  5KJL A;  5F6K C;  1N6A A;  4LDG A;  4O6F A;  5LSZ A;  4JLG A;  3RJW A;  2BQZ A;  4YPA A;  3PDN A;  5T0M A;  3DB5 A;  3OPE A;  3MEK A;  4WUY A;  1ML9 A;  5EX3 A;  3TG5 A;  4MI5 A;  5CPR B;  4I51 A;  5TTF A;  4J7I A;  3F9W A;  3SWC A;  3F9Y A;  2RFI A;  4QEN A;  2W5Y A;  5JJ0 A;  3M55 A;  4YPE A;  3KMA A;  1MUF A;  3HNA A;  4JDS A;  5ARF A;  4H12 A;  3RIB A;  3BO5 A;  1N3J A;  4MI0 A;  3KMT A;  5CCM A;  3TG4 A;  3QWV A;  5KJN A;  4YNP A;  3QWW A;  4IJ8 A;  5T0K A;  1O9S A;  3K5K A;  2IGQ A;  5AYF A;  4IJD A;  5JHN A;  3S7F A;  4J8O A;  3M59 A;  3CBO A;  5EX0 A;  4RZ0 A;  3F9Z A;  3M57 A;  5EG2 A;  2R3A A;  3OOI A;  5T5G A;  2G46 A;  3M53 A;  4O30 A;  5HQ8 A;  4NVQ A;  3MO0 A;  3S7B A;  4C1Q A;  3OXG A;  3MO2 A;  3S7D A;  5HI7 A;  3CBP A;  2O8J A;  3EP0 A;  3MO5 A;  3KMJ A;  3VV0 A;  3M5A A;  3M56 A;  5KJK A;  3QWP A;  4Z4P A;  5KJM A;  3SW9 A;  5LSX A;  2F69 A;  5F6L A;  5F5E A;  4AU7 A;  1MVX A;  4FMU A;  1XQH A;  4NJ5 A;  3IHX A;  3N71 A;  3M58 A;  3OS5 A;  3DAL A;  5JIN A;  4YNM A;  3CBM A;  3S7J A;  4BUP A;  4QEO A;  2JV0 A;  1MVH A;  5ARG A; 
#chains in the Genus database with same CATH homology
 1ZKK A;  3OXF A;  5F59 A;  1PEG A;  1H3I A;  2QPW A;  1MT6 A;  3RAY A;  4J83 A;  3M54 A;  5TEG A;  4YPU A;  3S8P A;  3RU0 A;  1N6C A;  4E47 A;  5TH7 A;  5CCL A;  3FPD A;  4J7F A;  2W5Z A;  3F9X A;  3VUZ A;  4YND A;  3OXL A;  4QEP A;  3RQ4 A;  5JIY A;  5KJL A;  5F6K C;  1N6A A;  4LDG A;  4O6F A;  5LSZ A;  4JLG A;  3RJW A;  2BQZ A;  4YPA A;  3PDN A;  5T0M A;  3DB5 A;  3OPE A;  3MEK A;  4WUY A;  1ML9 A;  5EX3 A;  3TG5 A;  4MI5 A;  5CPR B;  4I51 A;  5TTF A;  4J7I A;  3F9W A;  3SWC A;  3F9Y A;  2RFI A;  4QEN A;  2W5Y A;  5JJ0 A;  3M55 A;  4YPE A;  3KMA A;  1MUF A;  3HNA A;  4JDS A;  5ARF A;  4H12 A;  3RIB A;  3BO5 A;  1N3J A;  4MI0 A;  3KMT A;  5CCM A;  3TG4 A;  3QWV A;  5KJN A;  4YNP A;  3QWW A;  4IJ8 A;  5T0K A;  1O9S A;  3K5K A;  2IGQ A;  5AYF A;  4IJD A;  5JHN A;  3S7F A;  4J8O A;  3M59 A;  3CBO A;  5EX0 A;  4RZ0 A;  3F9Z A;  3M57 A;  5EG2 A;  2R3A A;  3OOI A;  5T5G A;  2G46 A;  3M53 A;  4O30 A;  5HQ8 A;  4NVQ A;  3MO0 A;  3S7B A;  4C1Q A;  3OXG A;  3MO2 A;  3S7D A;  5HI7 A;  3CBP A;  2O8J A;  3EP0 A;  3MO5 A;  3KMJ A;  3VV0 A;  3M5A A;  3M56 A;  5KJK A;  3QWP A;  4Z4P A;  5KJM A;  3SW9 A;  5LSX A;  2F69 A;  5F6L A;  5F5E A;  4AU7 A;  1MVX A;  4FMU A;  1XQH A;  4NJ5 A;  3IHX A;  3N71 A;  3M58 A;  3OS5 A;  3DAL A;  5JIN A;  4YNM A;  3CBM A;  3S7J A;  4BUP A;  4QEO A;  2JV0 A;  1MVH A;  5ARG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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