3HNAA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono-methylated h3k9 peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
280
Chain Sequence
GSNSQVWSALQMSKALPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
molecule tags Hydrolase/hydrolase regulator
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 75
structure length 280
sequence length 287
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3hnaA00
3VUZA 4YNPA 1N6CA 2JV0A 4NVQA 5JINA 2R3AA 1XQHA 4YNMA 5ARGA 3RIBA 4E47A 2BQZA 3MO5A 4YPUA 5ARFA 3RQ4A 3F9ZA 1O9SA 3M53A 5F59A 4NJ5A 3F9XA 4H12A 3TG4A 3M56A 5TEGA 5T5GA 3N71A 3TG5A 3OXLA 1MVXA 5CPRB 2QPWA 3BO5A 3S8PA 3RJWA 2W5ZA 3MO2A 3RAYA 3EP0A 3HNAA 4LDGA 4QEOA 3M55A 4RZ0A 5HQ8A 1N6AA 4J7FA 5AYFA 3S7JA 4IJDA 1ML9A 4J8OA 2G46A 4JLGA 5F6LA 5KJLA 5KJKA 3S7BA 3S7DA 2W5YA 5LSZA 1MT6A 3SW9A 5LSXA 3VV0A 3DB5A 4I51A 3FPDA 3CBPA 4YNDA 4O6FA 4FMUA 5EX0A 5T0MA 1N3JA 4MI5A 5CCMA 5F5EA 3OXGA 3CBMA 4YPAA 4BUPA 5JIYA 3M57A 2F69A 3S7FA 4AU7A 4QEPA 3M58A 4IJ8A 1PEGA 3RU0A 3KMAA 3KMJA 1H3IA 4C1QA 5JHNA 2O8JA 4J7IA 4Z4PA 3QWWA 5CCLA 3MEKA 3QWVA 5F6KC 4MI0A 3DALA 3IHXA 4JDSA 2RFIA 3M54A 3MO0A 3SWCA 3OXFA 5HI7A 3F9YA 3CBOA 4J83A 4YPEA 1MUFA 5TH7A 5KJMA 3F9WA 3QWPA 5EG2A 3M59A 5TTFA 3OOIA 1ZKKA 5T0KA 4QENA 4O30A 3K5KA 2IGQA 3M5AA 1MVHA 3PDNA 3OPEA 5JJ0A 5EX3A 5KJNA 4WUYA 3OS5A 3KMTA
chains in the Genus database with same CATH superfamily
3VUZA 4YNPA 1N6CA 2JV0A 4NVQA 5JINA 2R3AA 1XQHA 4YNMA 5ARGA 3RIBA 4E47A 2BQZA 3MO5A 4YPUA 5ARFA 3RQ4A 3F9ZA 1O9SA 3M53A 5F59A 4NJ5A 3F9XA 4H12A 3TG4A 3M56A 5TEGA 5T5GA 3N71A 3TG5A 3OXLA 1MVXA 5CPRB 2QPWA 3BO5A 3S8PA 3RJWA 2W5ZA 3MO2A 3RAYA 3EP0A 3HNAA 4LDGA 4QEOA 3M55A 4RZ0A 5HQ8A 1N6AA 4J7FA 5AYFA 3S7JA 4IJDA 1ML9A 4J8OA 2G46A 4JLGA 5F6LA 5KJLA 5KJKA 3S7BA 3S7DA 2W5YA 5LSZA 1MT6A 3SW9A 5LSXA 3VV0A 3DB5A 4I51A 3FPDA 3CBPA 4YNDA 4O6FA 4FMUA 5EX0A 5T0MA 1N3JA 4MI5A 5CCMA 5F5EA 3OXGA 3CBMA 4YPAA 4BUPA 5JIYA 3M57A 2F69A 3S7FA 4AU7A 4QEPA 3M58A 4IJ8A 1PEGA 3RU0A 3KMAA 3KMJA 1H3IA 4C1QA 5JHNA 2O8JA 4J7IA 4Z4PA 3QWWA 5CCLA 3MEKA 3QWVA 5F6KC 4MI0A 3DALA 3IHXA 4JDSA 2RFIA 3M54A 3MO0A 3SWCA 3OXFA 5HI7A 3F9YA 3CBOA 4J83A 4YPEA 1MUFA 5TH7A 5KJMA 3F9WA 3QWPA 5EG2A 3M59A 5TTFA 3OOIA 1ZKKA 5T0KA 4QENA 4O30A 3K5KA 2IGQA 3M5AA 1MVHA 3PDNA 3OPEA 5JJ0A 5EX3A 5KJNA 4WUYA 3OS5A 3KMTA
chains in the Genus database with same CATH topology
3VUZA 4YNPA 1N6CA 2JV0A 4NVQA 5JINA 2R3AA 1XQHA 4YNMA 5ARGA 3RIBA 4E47A 2BQZA 3MO5A 4YPUA 5ARFA 3RQ4A 3F9ZA 1O9SA 3M53A 5F59A 4NJ5A 3F9XA 4H12A 3TG4A 3M56A 5TEGA 5T5GA 3N71A 3TG5A 3OXLA 1MVXA 5CPRB 2QPWA 3BO5A 3S8PA 3RJWA 2W5ZA 3MO2A 3RAYA 3EP0A 3HNAA 4LDGA 4QEOA 3M55A 4RZ0A 5HQ8A 1N6AA 4J7FA 5AYFA 3S7JA 4IJDA 1ML9A 4J8OA 2G46A 4JLGA 5F6LA 5KJLA 5KJKA 3S7BA 3S7DA 2W5YA 5LSZA 1MT6A 3SW9A 5LSXA 3VV0A 3DB5A 4I51A 3FPDA 3CBPA 4YNDA 4O6FA 4FMUA 5EX0A 5T0MA 1N3JA 4MI5A 5CCMA 5F5EA 3OXGA 3CBMA 4YPAA 4BUPA 5JIYA 3M57A 2F69A 3S7FA 4AU7A 4QEPA 3M58A 4IJ8A 1PEGA 3RU0A 3KMAA 3KMJA 1H3IA 4C1QA 5JHNA 2O8JA 4J7IA 4Z4PA 3QWWA 5CCLA 3MEKA 3QWVA 5F6KC 4MI0A 3DALA 3IHXA 4JDSA 2RFIA 3M54A 3MO0A 3SWCA 3OXFA 5HI7A 3F9YA 3CBOA 4J83A 4YPEA 1MUFA 5TH7A 5KJMA 3F9WA 3QWPA 5EG2A 3M59A 5TTFA 3OOIA 1ZKKA 5T0KA 4QENA 4O30A 3K5KA 2IGQA 3M5AA 1MVHA 3PDNA 3OPEA 5JJ0A 5EX3A 5KJNA 4WUYA 3OS5A 3KMTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VUZ A;  4YNP A;  1N6C A;  2JV0 A;  4NVQ A;  5JIN A;  2R3A A;  1XQH A;  4YNM A;  5ARG A;  3RIB A;  4E47 A;  2BQZ A;  3MO5 A;  4YPU A;  5ARF A;  3RQ4 A;  3F9Z A;  1O9S A;  3M53 A;  5F59 A;  4NJ5 A;  3F9X A;  4H12 A;  3TG4 A;  3M56 A;  5TEG A;  5T5G A;  3N71 A;  3TG5 A;  3OXL A;  1MVX A;  5CPR B;  2QPW A;  3BO5 A;  3S8P A;  3RJW A;  2W5Z A;  3MO2 A;  3RAY A;  3EP0 A;  3HNA A;  4LDG A;  4QEO A;  3M55 A;  4RZ0 A;  5HQ8 A;  1N6A A;  4J7F A;  5AYF A;  3S7J A;  4IJD A;  1ML9 A;  4J8O A;  2G46 A;  4JLG A;  5F6L A;  5KJL A;  5KJK A;  3S7B A;  3S7D A;  2W5Y A;  5LSZ A;  1MT6 A;  3SW9 A;  5LSX A;  3VV0 A;  3DB5 A;  4I51 A;  3FPD A;  3CBP A;  4YND A;  4O6F A;  4FMU A;  5EX0 A;  5T0M A;  1N3J A;  4MI5 A;  5CCM A;  5F5E A;  3OXG A;  3CBM A;  4YPA A;  4BUP A;  5JIY A;  3M57 A;  2F69 A;  3S7F A;  4AU7 A;  4QEP A;  3M58 A;  4IJ8 A;  1PEG A;  3RU0 A;  3KMA A;  3KMJ A;  1H3I A;  4C1Q A;  5JHN A;  2O8J A;  4J7I A;  4Z4P A;  3QWW A;  5CCL A;  3MEK A;  3QWV A;  5F6K C;  4MI0 A;  3DAL A;  3IHX A;  4JDS A;  2RFI A;  3M54 A;  3MO0 A;  3SWC A;  3OXF A;  5HI7 A;  3F9Y A;  3CBO A;  4J83 A;  4YPE A;  1MUF A;  5TH7 A;  5KJM A;  3F9W A;  3QWP A;  5EG2 A;  3M59 A;  5TTF A;  3OOI A;  1ZKK A;  5T0K A;  4QEN A;  4O30 A;  3K5K A;  2IGQ A;  3M5A A;  1MVH A;  3PDN A;  3OPE A;  5JJ0 A;  5EX3 A;  5KJN A;  4WUY A;  3OS5 A;  3KMT A; 
#chains in the Genus database with same CATH topology
 3VUZ A;  4YNP A;  1N6C A;  2JV0 A;  4NVQ A;  5JIN A;  2R3A A;  1XQH A;  4YNM A;  5ARG A;  3RIB A;  4E47 A;  2BQZ A;  3MO5 A;  4YPU A;  5ARF A;  3RQ4 A;  3F9Z A;  1O9S A;  3M53 A;  5F59 A;  4NJ5 A;  3F9X A;  4H12 A;  3TG4 A;  3M56 A;  5TEG A;  5T5G A;  3N71 A;  3TG5 A;  3OXL A;  1MVX A;  5CPR B;  2QPW A;  3BO5 A;  3S8P A;  3RJW A;  2W5Z A;  3MO2 A;  3RAY A;  3EP0 A;  3HNA A;  4LDG A;  4QEO A;  3M55 A;  4RZ0 A;  5HQ8 A;  1N6A A;  4J7F A;  5AYF A;  3S7J A;  4IJD A;  1ML9 A;  4J8O A;  2G46 A;  4JLG A;  5F6L A;  5KJL A;  5KJK A;  3S7B A;  3S7D A;  2W5Y A;  5LSZ A;  1MT6 A;  3SW9 A;  5LSX A;  3VV0 A;  3DB5 A;  4I51 A;  3FPD A;  3CBP A;  4YND A;  4O6F A;  4FMU A;  5EX0 A;  5T0M A;  1N3J A;  4MI5 A;  5CCM A;  5F5E A;  3OXG A;  3CBM A;  4YPA A;  4BUP A;  5JIY A;  3M57 A;  2F69 A;  3S7F A;  4AU7 A;  4QEP A;  3M58 A;  4IJ8 A;  1PEG A;  3RU0 A;  3KMA A;  3KMJ A;  1H3I A;  4C1Q A;  5JHN A;  2O8J A;  4J7I A;  4Z4P A;  3QWW A;  5CCL A;  3MEK A;  3QWV A;  5F6K C;  4MI0 A;  3DAL A;  3IHX A;  4JDS A;  2RFI A;  3M54 A;  3MO0 A;  3SWC A;  3OXF A;  5HI7 A;  3F9Y A;  3CBO A;  4J83 A;  4YPE A;  1MUF A;  5TH7 A;  5KJM A;  3F9W A;  3QWP A;  5EG2 A;  3M59 A;  5TTF A;  3OOI A;  1ZKK A;  5T0K A;  4QEN A;  4O30 A;  3K5K A;  2IGQ A;  3M5A A;  1MVH A;  3PDN A;  3OPE A;  5JJ0 A;  5EX3 A;  5KJN A;  4WUY A;  3OS5 A;  3KMT A; 
#chains in the Genus database with same CATH homology
 3VUZ A;  4YNP A;  1N6C A;  2JV0 A;  4NVQ A;  5JIN A;  2R3A A;  1XQH A;  4YNM A;  5ARG A;  3RIB A;  4E47 A;  2BQZ A;  3MO5 A;  4YPU A;  5ARF A;  3RQ4 A;  3F9Z A;  1O9S A;  3M53 A;  5F59 A;  4NJ5 A;  3F9X A;  4H12 A;  3TG4 A;  3M56 A;  5TEG A;  5T5G A;  3N71 A;  3TG5 A;  3OXL A;  1MVX A;  5CPR B;  2QPW A;  3BO5 A;  3S8P A;  3RJW A;  2W5Z A;  3MO2 A;  3RAY A;  3EP0 A;  3HNA A;  4LDG A;  4QEO A;  3M55 A;  4RZ0 A;  5HQ8 A;  1N6A A;  4J7F A;  5AYF A;  3S7J A;  4IJD A;  1ML9 A;  4J8O A;  2G46 A;  4JLG A;  5F6L A;  5KJL A;  5KJK A;  3S7B A;  3S7D A;  2W5Y A;  5LSZ A;  1MT6 A;  3SW9 A;  5LSX A;  3VV0 A;  3DB5 A;  4I51 A;  3FPD A;  3CBP A;  4YND A;  4O6F A;  4FMU A;  5EX0 A;  5T0M A;  1N3J A;  4MI5 A;  5CCM A;  5F5E A;  3OXG A;  3CBM A;  4YPA A;  4BUP A;  5JIY A;  3M57 A;  2F69 A;  3S7F A;  4AU7 A;  4QEP A;  3M58 A;  4IJ8 A;  1PEG A;  3RU0 A;  3KMA A;  3KMJ A;  1H3I A;  4C1Q A;  5JHN A;  2O8J A;  4J7I A;  4Z4P A;  3QWW A;  5CCL A;  3MEK A;  3QWV A;  5F6K C;  4MI0 A;  3DAL A;  3IHX A;  4JDS A;  2RFI A;  3M54 A;  3MO0 A;  3SWC A;  3OXF A;  5HI7 A;  3F9Y A;  3CBO A;  4J83 A;  4YPE A;  1MUF A;  5TH7 A;  5KJM A;  3F9W A;  3QWP A;  5EG2 A;  3M59 A;  5TTF A;  3OOI A;  1ZKK A;  5T0K A;  4QEN A;  4O30 A;  3K5K A;  2IGQ A;  3M5A A;  1MVH A;  3PDN A;  3OPE A;  5JJ0 A;  5EX3 A;  5KJN A;  4WUY A;  3OS5 A;  3KMT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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