4C1QA

Crystal structure of the prdm9 set domain in complex with h3k4me2 and adohcy.
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
173
structure length
173
Chain Sequence
AMSQDDDYLYCEKCQNFFIDSCPNHGPPLFVKDSMVDRGHPNHSVLSLPPGLRISPSGIPEAGLGVWNEASDLPVGLHFGPYEGQITEDEEAANSGYSWLITKGRNCYEYVDGQDESQANWMRYVNCARDDEEQNLVAFQYHRKIFYRTCRVIRPGCELLVWYGDEYGQELGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of Prdm9.
pubmed doi rcsb
molecule tags Transferase/peptide
source organism Mus musculus
molecule keywords HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9
total genus 43
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4c1qA00
3CBPA 3S8PA 3DB5A 1H3IA 4YNMA 3FPDA 4C1QA 3MO5A 5HQ8A 5JJ0A 5F5EA 3RQ4A 3DALA 5EX0A 4LDGA 2JV0A 3MO0A 3QWVA 4J7FA 5JIYA 1XQHA 4Z4PA 4YNDA 3RU0A 5ARFA 4MI0A 3OXLA 1ZKKA 3VUZA 1N3JA 5AYFA 3TG5A 3OXGA 4O30A 5JINA 2RFIA 3RAYA 4QENA 3EP0A 5T0MA 3M59A 2W5ZA 3RIBA 4BUPA 4RZ0A 3QWPA 5F6LA 5KJNA 4J7IA 3M55A 3QWWA 4I51A 4IJ8A 3VV0A 3M57A 4QEOA 3PDNA 4E47A 3OPEA 5TH7A 2IGQA 4NVQA 3M54A 3OS5A 3CBMA 3KMAA 3OXFA 3S7DA 4QEPA 3M58A 3SWCA 3F9YA 4H12A 5CCMA 3RJWA 1PEGA 4MI5A 5TEGA 5LSZA 5T0KA 4JDSA 4JLGA 3M53A 1MVHA 2G46A 3TG4A 2W5YA 3S7FA 5JHNA 3M56A 3SW9A 1MUFA 3CBOA 3S7BA 3BO5A 1O9SA 2F69A 4O6FA 4AU7A 5F59A 5CCLA 3OOIA 5EG2A 3S7JA 3F9ZA 3IHXA 3N71A 5EX3A 5TTFA 5LSXA 4J83A 4YNPA 5HI7A 3K5KA 4WUYA 4FMUA 2O8JA 4J8OA 3F9WA 3MO2A 3KMTA 4YPAA 3M5AA 4IJDA 5CPRB 2R3AA 4YPEA 5KJKA 5KJMA 3KMJA 1ML9A 4YPUA 1N6CA 2BQZA 1N6AA 3MEKA 5F6KC 1MT6A 5ARGA 3HNAA 5T5GA 3F9XA 5KJLA 2QPWA 4NJ5A 1MVXA
chains in the Genus database with same CATH superfamily
3CBPA 3S8PA 3DB5A 1H3IA 4YNMA 3FPDA 4C1QA 3MO5A 5HQ8A 5JJ0A 5F5EA 3RQ4A 3DALA 5EX0A 4LDGA 2JV0A 3MO0A 3QWVA 4J7FA 5JIYA 1XQHA 4Z4PA 4YNDA 3RU0A 5ARFA 4MI0A 3OXLA 1ZKKA 3VUZA 1N3JA 5AYFA 3TG5A 3OXGA 4O30A 5JINA 2RFIA 3RAYA 4QENA 3EP0A 5T0MA 3M59A 2W5ZA 3RIBA 4BUPA 4RZ0A 3QWPA 5F6LA 5KJNA 4J7IA 3M55A 3QWWA 4I51A 4IJ8A 3VV0A 3M57A 4QEOA 3PDNA 4E47A 3OPEA 5TH7A 2IGQA 4NVQA 3M54A 3OS5A 3CBMA 3KMAA 3OXFA 3S7DA 4QEPA 3M58A 3SWCA 3F9YA 4H12A 5CCMA 3RJWA 1PEGA 4MI5A 5TEGA 5LSZA 5T0KA 4JDSA 4JLGA 3M53A 1MVHA 2G46A 3TG4A 2W5YA 3S7FA 5JHNA 3M56A 3SW9A 1MUFA 3CBOA 3S7BA 3BO5A 1O9SA 2F69A 4O6FA 4AU7A 5F59A 5CCLA 3OOIA 5EG2A 3S7JA 3F9ZA 3IHXA 3N71A 5EX3A 5TTFA 5LSXA 4J83A 4YNPA 5HI7A 3K5KA 4WUYA 4FMUA 2O8JA 4J8OA 3F9WA 3MO2A 3KMTA 4YPAA 3M5AA 4IJDA 5CPRB 2R3AA 4YPEA 5KJKA 5KJMA 3KMJA 1ML9A 4YPUA 1N6CA 2BQZA 1N6AA 3MEKA 5F6KC 1MT6A 5ARGA 3HNAA 5T5GA 3F9XA 5KJLA 2QPWA 4NJ5A 1MVXA
chains in the Genus database with same CATH topology
3CBPA 3S8PA 3DB5A 1H3IA 4YNMA 3FPDA 4C1QA 3MO5A 5HQ8A 5JJ0A 5F5EA 3RQ4A 3DALA 5EX0A 4LDGA 2JV0A 3MO0A 3QWVA 4J7FA 5JIYA 1XQHA 4Z4PA 4YNDA 3RU0A 5ARFA 4MI0A 3OXLA 1ZKKA 3VUZA 1N3JA 5AYFA 3TG5A 3OXGA 4O30A 5JINA 2RFIA 3RAYA 4QENA 3EP0A 5T0MA 3M59A 2W5ZA 3RIBA 4BUPA 4RZ0A 3QWPA 5F6LA 5KJNA 4J7IA 3M55A 3QWWA 4I51A 4IJ8A 3VV0A 3M57A 4QEOA 3PDNA 4E47A 3OPEA 5TH7A 2IGQA 4NVQA 3M54A 3OS5A 3CBMA 3KMAA 3OXFA 3S7DA 4QEPA 3M58A 3SWCA 3F9YA 4H12A 5CCMA 3RJWA 1PEGA 4MI5A 5TEGA 5LSZA 5T0KA 4JDSA 4JLGA 3M53A 1MVHA 2G46A 3TG4A 2W5YA 3S7FA 5JHNA 3M56A 3SW9A 1MUFA 3CBOA 3S7BA 3BO5A 1O9SA 2F69A 4O6FA 4AU7A 5F59A 5CCLA 3OOIA 5EG2A 3S7JA 3F9ZA 3IHXA 3N71A 5EX3A 5TTFA 5LSXA 4J83A 4YNPA 5HI7A 3K5KA 4WUYA 4FMUA 2O8JA 4J8OA 3F9WA 3MO2A 3KMTA 4YPAA 3M5AA 4IJDA 5CPRB 2R3AA 4YPEA 5KJKA 5KJMA 3KMJA 1ML9A 4YPUA 1N6CA 2BQZA 1N6AA 3MEKA 5F6KC 1MT6A 5ARGA 3HNAA 5T5GA 3F9XA 5KJLA 2QPWA 4NJ5A 1MVXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CBP A;  3S8P A;  3DB5 A;  1H3I A;  4YNM A;  3FPD A;  4C1Q A;  3MO5 A;  5HQ8 A;  5JJ0 A;  5F5E A;  3RQ4 A;  3DAL A;  5EX0 A;  4LDG A;  2JV0 A;  3MO0 A;  3QWV A;  4J7F A;  5JIY A;  1XQH A;  4Z4P A;  4YND A;  3RU0 A;  5ARF A;  4MI0 A;  3OXL A;  1ZKK A;  3VUZ A;  1N3J A;  5AYF A;  3TG5 A;  3OXG A;  4O30 A;  5JIN A;  2RFI A;  3RAY A;  4QEN A;  3EP0 A;  5T0M A;  3M59 A;  2W5Z A;  3RIB A;  4BUP A;  4RZ0 A;  3QWP A;  5F6L A;  5KJN A;  4J7I A;  3M55 A;  3QWW A;  4I51 A;  4IJ8 A;  3VV0 A;  3M57 A;  4QEO A;  3PDN A;  4E47 A;  3OPE A;  5TH7 A;  2IGQ A;  4NVQ A;  3M54 A;  3OS5 A;  3CBM A;  3KMA A;  3OXF A;  3S7D A;  4QEP A;  3M58 A;  3SWC A;  3F9Y A;  4H12 A;  5CCM A;  3RJW A;  1PEG A;  4MI5 A;  5TEG A;  5LSZ A;  5T0K A;  4JDS A;  4JLG A;  3M53 A;  1MVH A;  2G46 A;  3TG4 A;  2W5Y A;  3S7F A;  5JHN A;  3M56 A;  3SW9 A;  1MUF A;  3CBO A;  3S7B A;  3BO5 A;  1O9S A;  2F69 A;  4O6F A;  4AU7 A;  5F59 A;  5CCL A;  3OOI A;  5EG2 A;  3S7J A;  3F9Z A;  3IHX A;  3N71 A;  5EX3 A;  5TTF A;  5LSX A;  4J83 A;  4YNP A;  5HI7 A;  3K5K A;  4WUY A;  4FMU A;  2O8J A;  4J8O A;  3F9W A;  3MO2 A;  3KMT A;  4YPA A;  3M5A A;  4IJD A;  5CPR B;  2R3A A;  4YPE A;  5KJK A;  5KJM A;  3KMJ A;  1ML9 A;  4YPU A;  1N6C A;  2BQZ A;  1N6A A;  3MEK A;  5F6K C;  1MT6 A;  5ARG A;  3HNA A;  5T5G A;  3F9X A;  5KJL A;  2QPW A;  4NJ5 A;  1MVX A; 
#chains in the Genus database with same CATH topology
 3CBP A;  3S8P A;  3DB5 A;  1H3I A;  4YNM A;  3FPD A;  4C1Q A;  3MO5 A;  5HQ8 A;  5JJ0 A;  5F5E A;  3RQ4 A;  3DAL A;  5EX0 A;  4LDG A;  2JV0 A;  3MO0 A;  3QWV A;  4J7F A;  5JIY A;  1XQH A;  4Z4P A;  4YND A;  3RU0 A;  5ARF A;  4MI0 A;  3OXL A;  1ZKK A;  3VUZ A;  1N3J A;  5AYF A;  3TG5 A;  3OXG A;  4O30 A;  5JIN A;  2RFI A;  3RAY A;  4QEN A;  3EP0 A;  5T0M A;  3M59 A;  2W5Z A;  3RIB A;  4BUP A;  4RZ0 A;  3QWP A;  5F6L A;  5KJN A;  4J7I A;  3M55 A;  3QWW A;  4I51 A;  4IJ8 A;  3VV0 A;  3M57 A;  4QEO A;  3PDN A;  4E47 A;  3OPE A;  5TH7 A;  2IGQ A;  4NVQ A;  3M54 A;  3OS5 A;  3CBM A;  3KMA A;  3OXF A;  3S7D A;  4QEP A;  3M58 A;  3SWC A;  3F9Y A;  4H12 A;  5CCM A;  3RJW A;  1PEG A;  4MI5 A;  5TEG A;  5LSZ A;  5T0K A;  4JDS A;  4JLG A;  3M53 A;  1MVH A;  2G46 A;  3TG4 A;  2W5Y A;  3S7F A;  5JHN A;  3M56 A;  3SW9 A;  1MUF A;  3CBO A;  3S7B A;  3BO5 A;  1O9S A;  2F69 A;  4O6F A;  4AU7 A;  5F59 A;  5CCL A;  3OOI A;  5EG2 A;  3S7J A;  3F9Z A;  3IHX A;  3N71 A;  5EX3 A;  5TTF A;  5LSX A;  4J83 A;  4YNP A;  5HI7 A;  3K5K A;  4WUY A;  4FMU A;  2O8J A;  4J8O A;  3F9W A;  3MO2 A;  3KMT A;  4YPA A;  3M5A A;  4IJD A;  5CPR B;  2R3A A;  4YPE A;  5KJK A;  5KJM A;  3KMJ A;  1ML9 A;  4YPU A;  1N6C A;  2BQZ A;  1N6A A;  3MEK A;  5F6K C;  1MT6 A;  5ARG A;  3HNA A;  5T5G A;  3F9X A;  5KJL A;  2QPW A;  4NJ5 A;  1MVX A; 
#chains in the Genus database with same CATH homology
 3CBP A;  3S8P A;  3DB5 A;  1H3I A;  4YNM A;  3FPD A;  4C1Q A;  3MO5 A;  5HQ8 A;  5JJ0 A;  5F5E A;  3RQ4 A;  3DAL A;  5EX0 A;  4LDG A;  2JV0 A;  3MO0 A;  3QWV A;  4J7F A;  5JIY A;  1XQH A;  4Z4P A;  4YND A;  3RU0 A;  5ARF A;  4MI0 A;  3OXL A;  1ZKK A;  3VUZ A;  1N3J A;  5AYF A;  3TG5 A;  3OXG A;  4O30 A;  5JIN A;  2RFI A;  3RAY A;  4QEN A;  3EP0 A;  5T0M A;  3M59 A;  2W5Z A;  3RIB A;  4BUP A;  4RZ0 A;  3QWP A;  5F6L A;  5KJN A;  4J7I A;  3M55 A;  3QWW A;  4I51 A;  4IJ8 A;  3VV0 A;  3M57 A;  4QEO A;  3PDN A;  4E47 A;  3OPE A;  5TH7 A;  2IGQ A;  4NVQ A;  3M54 A;  3OS5 A;  3CBM A;  3KMA A;  3OXF A;  3S7D A;  4QEP A;  3M58 A;  3SWC A;  3F9Y A;  4H12 A;  5CCM A;  3RJW A;  1PEG A;  4MI5 A;  5TEG A;  5LSZ A;  5T0K A;  4JDS A;  4JLG A;  3M53 A;  1MVH A;  2G46 A;  3TG4 A;  2W5Y A;  3S7F A;  5JHN A;  3M56 A;  3SW9 A;  1MUF A;  3CBO A;  3S7B A;  3BO5 A;  1O9S A;  2F69 A;  4O6F A;  4AU7 A;  5F59 A;  5CCL A;  3OOI A;  5EG2 A;  3S7J A;  3F9Z A;  3IHX A;  3N71 A;  5EX3 A;  5TTF A;  5LSX A;  4J83 A;  4YNP A;  5HI7 A;  3K5K A;  4WUY A;  4FMU A;  2O8J A;  4J8O A;  3F9W A;  3MO2 A;  3KMT A;  4YPA A;  3M5A A;  4IJD A;  5CPR B;  2R3A A;  4YPE A;  5KJK A;  5KJM A;  3KMJ A;  1ML9 A;  4YPU A;  1N6C A;  2BQZ A;  1N6A A;  3MEK A;  5F6K C;  1MT6 A;  5ARG A;  3HNA A;  5T5G A;  3F9X A;  5KJL A;  2QPW A;  4NJ5 A;  1MVX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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