4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
molecule tags Transferase/peptide
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase EHMT1
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
3F9YA 5EG2A 3SWCA 1MT6A 5T5GA 2R3AA 3S7DA 3M55A 3OXGA 3FPDA 3F9WA 3MO5A 3RQ4A 4IJ8A 4J8OA 4NJ5A 4MI5A 4J7FA 3N71A 3RJWA 1XQHA 4I51A 5ARFA 1MUFA 3OXFA 3S8PA 5ARGA 5KJNA 3M53A 4QENA 5LSZA 3S7BA 5F5EA 5TEGA 5F59A 4YNMA 4J7IA 5KJLA 4NVQA 3QWVA 5CCLA 1MVHA 5LSXA 3CBPA 3M57A 3MEKA 3QWWA 3SW9A 3M5AA 3MO0A 2O8JA 4YPEA 2IGQA 3F9ZA 4J83A 1PEGA 3HNAA 3TG5A 4LDGA 3M59A 4Z4PA 5T0KA 5F6KC 3MO2A 3CBOA 4C1QA 3CBMA 5JHNA 4YPUA 3BO5A 3KMTA 4FMUA 3DALA 5EX3A 3M54A 3VUZA 5F6LA 5JIYA 4E47A 5TH7A 5TTFA 4YPAA 4YNPA 3OS5A 4JDSA 2W5ZA 5CCMA 3VV0A 4MI0A 5CPRB 1N6CA 3KMAA 5KJKA 3PDNA 3S7FA 4O6FA 4H12A 4YNDA 1N6AA 2G46A 3M58A 1MVXA 4RZ0A 4QEPA 2QPWA 4BUPA 1ZKKA 1O9SA 2W5YA 2BQZA 1H3IA 4AU7A 3S7JA 4JLGA 3DB5A 1ML9A 5AYFA 4O30A 3EP0A 3M56A 3OPEA 5EX0A 2JV0A 4IJDA 2RFIA 3OOIA 4WUYA 3RU0A 5JINA 3K5KA 3QWPA 5JJ0A 4QEOA 5HI7A 5HQ8A 3RAYA 3OXLA 5T0MA 1N3JA 3RIBA 2F69A 3IHXA 3F9XA 5KJMA 3KMJA 3TG4A
chains in the Genus database with same CATH superfamily
3F9YA 5EG2A 3SWCA 1MT6A 5T5GA 2R3AA 3S7DA 3M55A 3OXGA 3FPDA 3F9WA 3MO5A 3RQ4A 4IJ8A 4J8OA 4NJ5A 4MI5A 4J7FA 3N71A 3RJWA 1XQHA 4I51A 5ARFA 1MUFA 3OXFA 3S8PA 5ARGA 5KJNA 3M53A 4QENA 5LSZA 3S7BA 5F5EA 5TEGA 5F59A 4YNMA 4J7IA 5KJLA 4NVQA 3QWVA 5CCLA 1MVHA 5LSXA 3CBPA 3M57A 3MEKA 3QWWA 3SW9A 3M5AA 3MO0A 2O8JA 4YPEA 2IGQA 3F9ZA 4J83A 1PEGA 3HNAA 3TG5A 4LDGA 3M59A 4Z4PA 5T0KA 5F6KC 3MO2A 3CBOA 4C1QA 3CBMA 5JHNA 4YPUA 3BO5A 3KMTA 4FMUA 3DALA 5EX3A 3M54A 3VUZA 5F6LA 5JIYA 4E47A 5TH7A 5TTFA 4YPAA 4YNPA 3OS5A 4JDSA 2W5ZA 5CCMA 3VV0A 4MI0A 5CPRB 1N6CA 3KMAA 5KJKA 3PDNA 3S7FA 4O6FA 4H12A 4YNDA 1N6AA 2G46A 3M58A 1MVXA 4RZ0A 4QEPA 2QPWA 4BUPA 1ZKKA 1O9SA 2W5YA 2BQZA 1H3IA 4AU7A 3S7JA 4JLGA 3DB5A 1ML9A 5AYFA 4O30A 3EP0A 3M56A 3OPEA 5EX0A 2JV0A 4IJDA 2RFIA 3OOIA 4WUYA 3RU0A 5JINA 3K5KA 3QWPA 5JJ0A 4QEOA 5HI7A 5HQ8A 3RAYA 3OXLA 5T0MA 1N3JA 3RIBA 2F69A 3IHXA 3F9XA 5KJMA 3KMJA 3TG4A
chains in the Genus database with same CATH topology
3F9YA 5EG2A 3SWCA 1MT6A 5T5GA 2R3AA 3S7DA 3M55A 3OXGA 3FPDA 3F9WA 3MO5A 3RQ4A 4IJ8A 4J8OA 4NJ5A 4MI5A 4J7FA 3N71A 3RJWA 1XQHA 4I51A 5ARFA 1MUFA 3OXFA 3S8PA 5ARGA 5KJNA 3M53A 4QENA 5LSZA 3S7BA 5F5EA 5TEGA 5F59A 4YNMA 4J7IA 5KJLA 4NVQA 3QWVA 5CCLA 1MVHA 5LSXA 3CBPA 3M57A 3MEKA 3QWWA 3SW9A 3M5AA 3MO0A 2O8JA 4YPEA 2IGQA 3F9ZA 4J83A 1PEGA 3HNAA 3TG5A 4LDGA 3M59A 4Z4PA 5T0KA 5F6KC 3MO2A 3CBOA 4C1QA 3CBMA 5JHNA 4YPUA 3BO5A 3KMTA 4FMUA 3DALA 5EX3A 3M54A 3VUZA 5F6LA 5JIYA 4E47A 5TH7A 5TTFA 4YPAA 4YNPA 3OS5A 4JDSA 2W5ZA 5CCMA 3VV0A 4MI0A 5CPRB 1N6CA 3KMAA 5KJKA 3PDNA 3S7FA 4O6FA 4H12A 4YNDA 1N6AA 2G46A 3M58A 1MVXA 4RZ0A 4QEPA 2QPWA 4BUPA 1ZKKA 1O9SA 2W5YA 2BQZA 1H3IA 4AU7A 3S7JA 4JLGA 3DB5A 1ML9A 5AYFA 4O30A 3EP0A 3M56A 3OPEA 5EX0A 2JV0A 4IJDA 2RFIA 3OOIA 4WUYA 3RU0A 5JINA 3K5KA 3QWPA 5JJ0A 4QEOA 5HI7A 5HQ8A 3RAYA 3OXLA 5T0MA 1N3JA 3RIBA 2F69A 3IHXA 3F9XA 5KJMA 3KMJA 3TG4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F9Y A;  5EG2 A;  3SWC A;  1MT6 A;  5T5G A;  2R3A A;  3S7D A;  3M55 A;  3OXG A;  3FPD A;  3F9W A;  3MO5 A;  3RQ4 A;  4IJ8 A;  4J8O A;  4NJ5 A;  4MI5 A;  4J7F A;  3N71 A;  3RJW A;  1XQH A;  4I51 A;  5ARF A;  1MUF A;  3OXF A;  3S8P A;  5ARG A;  5KJN A;  3M53 A;  4QEN A;  5LSZ A;  3S7B A;  5F5E A;  5TEG A;  5F59 A;  4YNM A;  4J7I A;  5KJL A;  4NVQ A;  3QWV A;  5CCL A;  1MVH A;  5LSX A;  3CBP A;  3M57 A;  3MEK A;  3QWW A;  3SW9 A;  3M5A A;  3MO0 A;  2O8J A;  4YPE A;  2IGQ A;  3F9Z A;  4J83 A;  1PEG A;  3HNA A;  3TG5 A;  4LDG A;  3M59 A;  4Z4P A;  5T0K A;  5F6K C;  3MO2 A;  3CBO A;  4C1Q A;  3CBM A;  5JHN A;  4YPU A;  3BO5 A;  3KMT A;  4FMU A;  3DAL A;  5EX3 A;  3M54 A;  3VUZ A;  5F6L A;  5JIY A;  4E47 A;  5TH7 A;  5TTF A;  4YPA A;  4YNP A;  3OS5 A;  4JDS A;  2W5Z A;  5CCM A;  3VV0 A;  4MI0 A;  5CPR B;  1N6C A;  3KMA A;  5KJK A;  3PDN A;  3S7F A;  4O6F A;  4H12 A;  4YND A;  1N6A A;  2G46 A;  3M58 A;  1MVX A;  4RZ0 A;  4QEP A;  2QPW A;  4BUP A;  1ZKK A;  1O9S A;  2W5Y A;  2BQZ A;  1H3I A;  4AU7 A;  3S7J A;  4JLG A;  3DB5 A;  1ML9 A;  5AYF A;  4O30 A;  3EP0 A;  3M56 A;  3OPE A;  5EX0 A;  2JV0 A;  4IJD A;  2RFI A;  3OOI A;  4WUY A;  3RU0 A;  5JIN A;  3K5K A;  3QWP A;  5JJ0 A;  4QEO A;  5HI7 A;  5HQ8 A;  3RAY A;  3OXL A;  5T0M A;  1N3J A;  3RIB A;  2F69 A;  3IHX A;  3F9X A;  5KJM A;  3KMJ A;  3TG4 A; 
#chains in the Genus database with same CATH topology
 3F9Y A;  5EG2 A;  3SWC A;  1MT6 A;  5T5G A;  2R3A A;  3S7D A;  3M55 A;  3OXG A;  3FPD A;  3F9W A;  3MO5 A;  3RQ4 A;  4IJ8 A;  4J8O A;  4NJ5 A;  4MI5 A;  4J7F A;  3N71 A;  3RJW A;  1XQH A;  4I51 A;  5ARF A;  1MUF A;  3OXF A;  3S8P A;  5ARG A;  5KJN A;  3M53 A;  4QEN A;  5LSZ A;  3S7B A;  5F5E A;  5TEG A;  5F59 A;  4YNM A;  4J7I A;  5KJL A;  4NVQ A;  3QWV A;  5CCL A;  1MVH A;  5LSX A;  3CBP A;  3M57 A;  3MEK A;  3QWW A;  3SW9 A;  3M5A A;  3MO0 A;  2O8J A;  4YPE A;  2IGQ A;  3F9Z A;  4J83 A;  1PEG A;  3HNA A;  3TG5 A;  4LDG A;  3M59 A;  4Z4P A;  5T0K A;  5F6K C;  3MO2 A;  3CBO A;  4C1Q A;  3CBM A;  5JHN A;  4YPU A;  3BO5 A;  3KMT A;  4FMU A;  3DAL A;  5EX3 A;  3M54 A;  3VUZ A;  5F6L A;  5JIY A;  4E47 A;  5TH7 A;  5TTF A;  4YPA A;  4YNP A;  3OS5 A;  4JDS A;  2W5Z A;  5CCM A;  3VV0 A;  4MI0 A;  5CPR B;  1N6C A;  3KMA A;  5KJK A;  3PDN A;  3S7F A;  4O6F A;  4H12 A;  4YND A;  1N6A A;  2G46 A;  3M58 A;  1MVX A;  4RZ0 A;  4QEP A;  2QPW A;  4BUP A;  1ZKK A;  1O9S A;  2W5Y A;  2BQZ A;  1H3I A;  4AU7 A;  3S7J A;  4JLG A;  3DB5 A;  1ML9 A;  5AYF A;  4O30 A;  3EP0 A;  3M56 A;  3OPE A;  5EX0 A;  2JV0 A;  4IJD A;  2RFI A;  3OOI A;  4WUY A;  3RU0 A;  5JIN A;  3K5K A;  3QWP A;  5JJ0 A;  4QEO A;  5HI7 A;  5HQ8 A;  3RAY A;  3OXL A;  5T0M A;  1N3J A;  3RIB A;  2F69 A;  3IHX A;  3F9X A;  5KJM A;  3KMJ A;  3TG4 A; 
#chains in the Genus database with same CATH homology
 3F9Y A;  5EG2 A;  3SWC A;  1MT6 A;  5T5G A;  2R3A A;  3S7D A;  3M55 A;  3OXG A;  3FPD A;  3F9W A;  3MO5 A;  3RQ4 A;  4IJ8 A;  4J8O A;  4NJ5 A;  4MI5 A;  4J7F A;  3N71 A;  3RJW A;  1XQH A;  4I51 A;  5ARF A;  1MUF A;  3OXF A;  3S8P A;  5ARG A;  5KJN A;  3M53 A;  4QEN A;  5LSZ A;  3S7B A;  5F5E A;  5TEG A;  5F59 A;  4YNM A;  4J7I A;  5KJL A;  4NVQ A;  3QWV A;  5CCL A;  1MVH A;  5LSX A;  3CBP A;  3M57 A;  3MEK A;  3QWW A;  3SW9 A;  3M5A A;  3MO0 A;  2O8J A;  4YPE A;  2IGQ A;  3F9Z A;  4J83 A;  1PEG A;  3HNA A;  3TG5 A;  4LDG A;  3M59 A;  4Z4P A;  5T0K A;  5F6K C;  3MO2 A;  3CBO A;  4C1Q A;  3CBM A;  5JHN A;  4YPU A;  3BO5 A;  3KMT A;  4FMU A;  3DAL A;  5EX3 A;  3M54 A;  3VUZ A;  5F6L A;  5JIY A;  4E47 A;  5TH7 A;  5TTF A;  4YPA A;  4YNP A;  3OS5 A;  4JDS A;  2W5Z A;  5CCM A;  3VV0 A;  4MI0 A;  5CPR B;  1N6C A;  3KMA A;  5KJK A;  3PDN A;  3S7F A;  4O6F A;  4H12 A;  4YND A;  1N6A A;  2G46 A;  3M58 A;  1MVX A;  4RZ0 A;  4QEP A;  2QPW A;  4BUP A;  1ZKK A;  1O9S A;  2W5Y A;  2BQZ A;  1H3I A;  4AU7 A;  3S7J A;  4JLG A;  3DB5 A;  1ML9 A;  5AYF A;  4O30 A;  3EP0 A;  3M56 A;  3OPE A;  5EX0 A;  2JV0 A;  4IJD A;  2RFI A;  3OOI A;  4WUY A;  3RU0 A;  5JIN A;  3K5K A;  3QWP A;  5JJ0 A;  4QEO A;  5HI7 A;  5HQ8 A;  3RAY A;  3OXL A;  5T0M A;  1N3J A;  3RIB A;  2F69 A;  3IHX A;  3F9X A;  5KJM A;  3KMJ A;  3TG4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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