4IJ8A

Crystal structure of the complex of setd8 with sam
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
161
structure length
161
Chain Sequence
RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKSGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the complex of SETD8 with SAM
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords N-lysine methyltransferase SETD8
total genus 44
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-12-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4ij8A00
1H3IA 3M58A 4YNMA 5T0KA 2R3AA 5JHNA 3F9YA 3CBOA 3MO0A 4QENA 2BQZA 3EP0A 5CPRB 3F9XA 4RZ0A 5JIYA 3QWPA 2QPWA 3N71A 3DB5A 5AYFA 3SWCA 3F9ZA 3S7FA 4IJ8A 5KJMA 5F59A 3S7JA 4NVQA 5JJ0A 3F9WA 3M53A 3OS5A 1PEGA 5EG2A 3M5AA 3S7BA 4J8OA 2W5YA 4QEPA 1N6AA 3OPEA 3OXFA 5HQ8A 3PDNA 1MVHA 4YNPA 3M54A 3KMTA 4MI5A 5F6KC 3HNAA 4LDGA 5F5EA 4J83A 3DALA 3RJWA 3FPDA 3M55A 3VUZA 4E47A 3CBPA 4C1QA 3TG5A 5CCMA 1ML9A 3S7DA 5JINA 3M57A 4O30A 1ZKKA 5LSZA 3RQ4A 3MO2A 5LSXA 4QEOA 5HI7A 1XQHA 4Z4PA 3KMJA 2G46A 4BUPA 2RFIA 5CCLA 4JLGA 3K5KA 5T5GA 1MT6A 3M59A 4IJDA 5EX0A 3IHXA 3MO5A 3VV0A 3S8PA 4YPUA 3KMAA 4H12A 4YNDA 4YPAA 3M56A 2IGQA 5TTFA 5EX3A 5ARGA 3OXGA 4MI0A 3QWVA 4J7IA 2F69A 1MUFA 3RIBA 5F6LA 3MEKA 4FMUA 3RAYA 3RU0A 5TH7A 3QWWA 5KJNA 4AU7A 4JDSA 4WUYA 1N6CA 5KJKA 4I51A 5ARFA 3TG4A 3OOIA 3SW9A 5KJLA 1MVXA 1N3JA 2O8JA 3CBMA 4J7FA 3OXLA 3BO5A 1O9SA 4NJ5A 2W5ZA 4O6FA 5T0MA 4YPEA 5TEGA 2JV0A
chains in the Genus database with same CATH superfamily
1H3IA 3M58A 4YNMA 5T0KA 2R3AA 5JHNA 3F9YA 3CBOA 3MO0A 4QENA 2BQZA 3EP0A 5CPRB 3F9XA 4RZ0A 5JIYA 3QWPA 2QPWA 3N71A 3DB5A 5AYFA 3SWCA 3F9ZA 3S7FA 4IJ8A 5KJMA 5F59A 3S7JA 4NVQA 5JJ0A 3F9WA 3M53A 3OS5A 1PEGA 5EG2A 3M5AA 3S7BA 4J8OA 2W5YA 4QEPA 1N6AA 3OPEA 3OXFA 5HQ8A 3PDNA 1MVHA 4YNPA 3M54A 3KMTA 4MI5A 5F6KC 3HNAA 4LDGA 5F5EA 4J83A 3DALA 3RJWA 3FPDA 3M55A 3VUZA 4E47A 3CBPA 4C1QA 3TG5A 5CCMA 1ML9A 3S7DA 5JINA 3M57A 4O30A 1ZKKA 5LSZA 3RQ4A 3MO2A 5LSXA 4QEOA 5HI7A 1XQHA 4Z4PA 3KMJA 2G46A 4BUPA 2RFIA 5CCLA 4JLGA 3K5KA 5T5GA 1MT6A 3M59A 4IJDA 5EX0A 3IHXA 3MO5A 3VV0A 3S8PA 4YPUA 3KMAA 4H12A 4YNDA 4YPAA 3M56A 2IGQA 5TTFA 5EX3A 5ARGA 3OXGA 4MI0A 3QWVA 4J7IA 2F69A 1MUFA 3RIBA 5F6LA 3MEKA 4FMUA 3RAYA 3RU0A 5TH7A 3QWWA 5KJNA 4AU7A 4JDSA 4WUYA 1N6CA 5KJKA 4I51A 5ARFA 3TG4A 3OOIA 3SW9A 5KJLA 1MVXA 1N3JA 2O8JA 3CBMA 4J7FA 3OXLA 3BO5A 1O9SA 4NJ5A 2W5ZA 4O6FA 5T0MA 4YPEA 5TEGA 2JV0A
chains in the Genus database with same CATH topology
1H3IA 3M58A 4YNMA 5T0KA 2R3AA 5JHNA 3F9YA 3CBOA 3MO0A 4QENA 2BQZA 3EP0A 5CPRB 3F9XA 4RZ0A 5JIYA 3QWPA 2QPWA 3N71A 3DB5A 5AYFA 3SWCA 3F9ZA 3S7FA 4IJ8A 5KJMA 5F59A 3S7JA 4NVQA 5JJ0A 3F9WA 3M53A 3OS5A 1PEGA 5EG2A 3M5AA 3S7BA 4J8OA 2W5YA 4QEPA 1N6AA 3OPEA 3OXFA 5HQ8A 3PDNA 1MVHA 4YNPA 3M54A 3KMTA 4MI5A 5F6KC 3HNAA 4LDGA 5F5EA 4J83A 3DALA 3RJWA 3FPDA 3M55A 3VUZA 4E47A 3CBPA 4C1QA 3TG5A 5CCMA 1ML9A 3S7DA 5JINA 3M57A 4O30A 1ZKKA 5LSZA 3RQ4A 3MO2A 5LSXA 4QEOA 5HI7A 1XQHA 4Z4PA 3KMJA 2G46A 4BUPA 2RFIA 5CCLA 4JLGA 3K5KA 5T5GA 1MT6A 3M59A 4IJDA 5EX0A 3IHXA 3MO5A 3VV0A 3S8PA 4YPUA 3KMAA 4H12A 4YNDA 4YPAA 3M56A 2IGQA 5TTFA 5EX3A 5ARGA 3OXGA 4MI0A 3QWVA 4J7IA 2F69A 1MUFA 3RIBA 5F6LA 3MEKA 4FMUA 3RAYA 3RU0A 5TH7A 3QWWA 5KJNA 4AU7A 4JDSA 4WUYA 1N6CA 5KJKA 4I51A 5ARFA 3TG4A 3OOIA 3SW9A 5KJLA 1MVXA 1N3JA 2O8JA 3CBMA 4J7FA 3OXLA 3BO5A 1O9SA 4NJ5A 2W5ZA 4O6FA 5T0MA 4YPEA 5TEGA 2JV0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H3I A;  3M58 A;  4YNM A;  5T0K A;  2R3A A;  5JHN A;  3F9Y A;  3CBO A;  3MO0 A;  4QEN A;  2BQZ A;  3EP0 A;  5CPR B;  3F9X A;  4RZ0 A;  5JIY A;  3QWP A;  2QPW A;  3N71 A;  3DB5 A;  5AYF A;  3SWC A;  3F9Z A;  3S7F A;  4IJ8 A;  5KJM A;  5F59 A;  3S7J A;  4NVQ A;  5JJ0 A;  3F9W A;  3M53 A;  3OS5 A;  1PEG A;  5EG2 A;  3M5A A;  3S7B A;  4J8O A;  2W5Y A;  4QEP A;  1N6A A;  3OPE A;  3OXF A;  5HQ8 A;  3PDN A;  1MVH A;  4YNP A;  3M54 A;  3KMT A;  4MI5 A;  5F6K C;  3HNA A;  4LDG A;  5F5E A;  4J83 A;  3DAL A;  3RJW A;  3FPD A;  3M55 A;  3VUZ A;  4E47 A;  3CBP A;  4C1Q A;  3TG5 A;  5CCM A;  1ML9 A;  3S7D A;  5JIN A;  3M57 A;  4O30 A;  1ZKK A;  5LSZ A;  3RQ4 A;  3MO2 A;  5LSX A;  4QEO A;  5HI7 A;  1XQH A;  4Z4P A;  3KMJ A;  2G46 A;  4BUP A;  2RFI A;  5CCL A;  4JLG A;  3K5K A;  5T5G A;  1MT6 A;  3M59 A;  4IJD A;  5EX0 A;  3IHX A;  3MO5 A;  3VV0 A;  3S8P A;  4YPU A;  3KMA A;  4H12 A;  4YND A;  4YPA A;  3M56 A;  2IGQ A;  5TTF A;  5EX3 A;  5ARG A;  3OXG A;  4MI0 A;  3QWV A;  4J7I A;  2F69 A;  1MUF A;  3RIB A;  5F6L A;  3MEK A;  4FMU A;  3RAY A;  3RU0 A;  5TH7 A;  3QWW A;  5KJN A;  4AU7 A;  4JDS A;  4WUY A;  1N6C A;  5KJK A;  4I51 A;  5ARF A;  3TG4 A;  3OOI A;  3SW9 A;  5KJL A;  1MVX A;  1N3J A;  2O8J A;  3CBM A;  4J7F A;  3OXL A;  3BO5 A;  1O9S A;  4NJ5 A;  2W5Z A;  4O6F A;  5T0M A;  4YPE A;  5TEG A;  2JV0 A; 
#chains in the Genus database with same CATH topology
 1H3I A;  3M58 A;  4YNM A;  5T0K A;  2R3A A;  5JHN A;  3F9Y A;  3CBO A;  3MO0 A;  4QEN A;  2BQZ A;  3EP0 A;  5CPR B;  3F9X A;  4RZ0 A;  5JIY A;  3QWP A;  2QPW A;  3N71 A;  3DB5 A;  5AYF A;  3SWC A;  3F9Z A;  3S7F A;  4IJ8 A;  5KJM A;  5F59 A;  3S7J A;  4NVQ A;  5JJ0 A;  3F9W A;  3M53 A;  3OS5 A;  1PEG A;  5EG2 A;  3M5A A;  3S7B A;  4J8O A;  2W5Y A;  4QEP A;  1N6A A;  3OPE A;  3OXF A;  5HQ8 A;  3PDN A;  1MVH A;  4YNP A;  3M54 A;  3KMT A;  4MI5 A;  5F6K C;  3HNA A;  4LDG A;  5F5E A;  4J83 A;  3DAL A;  3RJW A;  3FPD A;  3M55 A;  3VUZ A;  4E47 A;  3CBP A;  4C1Q A;  3TG5 A;  5CCM A;  1ML9 A;  3S7D A;  5JIN A;  3M57 A;  4O30 A;  1ZKK A;  5LSZ A;  3RQ4 A;  3MO2 A;  5LSX A;  4QEO A;  5HI7 A;  1XQH A;  4Z4P A;  3KMJ A;  2G46 A;  4BUP A;  2RFI A;  5CCL A;  4JLG A;  3K5K A;  5T5G A;  1MT6 A;  3M59 A;  4IJD A;  5EX0 A;  3IHX A;  3MO5 A;  3VV0 A;  3S8P A;  4YPU A;  3KMA A;  4H12 A;  4YND A;  4YPA A;  3M56 A;  2IGQ A;  5TTF A;  5EX3 A;  5ARG A;  3OXG A;  4MI0 A;  3QWV A;  4J7I A;  2F69 A;  1MUF A;  3RIB A;  5F6L A;  3MEK A;  4FMU A;  3RAY A;  3RU0 A;  5TH7 A;  3QWW A;  5KJN A;  4AU7 A;  4JDS A;  4WUY A;  1N6C A;  5KJK A;  4I51 A;  5ARF A;  3TG4 A;  3OOI A;  3SW9 A;  5KJL A;  1MVX A;  1N3J A;  2O8J A;  3CBM A;  4J7F A;  3OXL A;  3BO5 A;  1O9S A;  4NJ5 A;  2W5Z A;  4O6F A;  5T0M A;  4YPE A;  5TEG A;  2JV0 A; 
#chains in the Genus database with same CATH homology
 1H3I A;  3M58 A;  4YNM A;  5T0K A;  2R3A A;  5JHN A;  3F9Y A;  3CBO A;  3MO0 A;  4QEN A;  2BQZ A;  3EP0 A;  5CPR B;  3F9X A;  4RZ0 A;  5JIY A;  3QWP A;  2QPW A;  3N71 A;  3DB5 A;  5AYF A;  3SWC A;  3F9Z A;  3S7F A;  4IJ8 A;  5KJM A;  5F59 A;  3S7J A;  4NVQ A;  5JJ0 A;  3F9W A;  3M53 A;  3OS5 A;  1PEG A;  5EG2 A;  3M5A A;  3S7B A;  4J8O A;  2W5Y A;  4QEP A;  1N6A A;  3OPE A;  3OXF A;  5HQ8 A;  3PDN A;  1MVH A;  4YNP A;  3M54 A;  3KMT A;  4MI5 A;  5F6K C;  3HNA A;  4LDG A;  5F5E A;  4J83 A;  3DAL A;  3RJW A;  3FPD A;  3M55 A;  3VUZ A;  4E47 A;  3CBP A;  4C1Q A;  3TG5 A;  5CCM A;  1ML9 A;  3S7D A;  5JIN A;  3M57 A;  4O30 A;  1ZKK A;  5LSZ A;  3RQ4 A;  3MO2 A;  5LSX A;  4QEO A;  5HI7 A;  1XQH A;  4Z4P A;  3KMJ A;  2G46 A;  4BUP A;  2RFI A;  5CCL A;  4JLG A;  3K5K A;  5T5G A;  1MT6 A;  3M59 A;  4IJD A;  5EX0 A;  3IHX A;  3MO5 A;  3VV0 A;  3S8P A;  4YPU A;  3KMA A;  4H12 A;  4YND A;  4YPA A;  3M56 A;  2IGQ A;  5TTF A;  5EX3 A;  5ARG A;  3OXG A;  4MI0 A;  3QWV A;  4J7I A;  2F69 A;  1MUF A;  3RIB A;  5F6L A;  3MEK A;  4FMU A;  3RAY A;  3RU0 A;  5TH7 A;  3QWW A;  5KJN A;  4AU7 A;  4JDS A;  4WUY A;  1N6C A;  5KJK A;  4I51 A;  5ARF A;  3TG4 A;  3OOI A;  3SW9 A;  5KJL A;  1MVX A;  1N3J A;  2O8J A;  3CBM A;  4J7F A;  3OXL A;  3BO5 A;  1O9S A;  4NJ5 A;  2W5Z A;  4O6F A;  5T0M A;  4YPE A;  5TEG A;  2JV0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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