The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
46
|
sequence length |
210
|
structure length |
208
|
Chain Sequence |
YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
pubmed doi rcsb |
| molecule tags |
Transferase
|
| source organism |
Homo sapiens
|
| molecule keywords |
Histone-lysine N-methyltransferase EZH2
|
| total genus |
46
|
| structure length |
208
|
| sequence length |
210
|
| ec nomenclature |
ec
2.1.1.43: Histone-lysine N-methyltransferase. |
| pdb deposition date | 2013-08-30 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00856 | SET | SET domain |
| A | PF18264 | preSET_CXC | CXC domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Beta Complex | Beta-clip-like | SET domain |
#chains in the Genus database with same CATH superfamily 3S7J A; 4MI0 A; 4MI5 A; 3MO5 A; 4H12 A; 5KJN A; 3VUZ A; 3BO5 A; 4YNP A; 5F59 A; 4YPE A; 3RQ4 A; 2QPW A; 1PEG A; 3QWP A; 3DB5 A; 3HNA A; 3M53 A; 5LSZ A; 5ARF A; 5TTF A; 2G46 A; 3KMA A; 4RZ0 A; 5CPR B; 5KJK A; 3FPD A; 3KMJ A; 3S7F A; 2RFI A; 2JV0 A; 4J7I A; 3OXG A; 5CCL A; 5ARG A; 4QEP A; 3OPE A; 3M59 A; 5EX3 A; 3M5A A; 3F9Y A; 5TEG A; 4YPA A; 3TG4 A; 1N6A A; 5JHN A; 3PDN A; 5KJM A; 3M58 A; 4J83 A; 3SW9 A; 3QWW A; 3MO0 A; 3OS5 A; 4YPU A; 3DAL A; 3VV0 A; 5JIY A; 4AU7 A; 5T5G A; 4J7F A; 4JLG A; 5F5E A; 5EG2 A; 3CBP A; 3M54 A; 4I51 A; 5TH7 A; 1N3J A; 3RAY A; 5CCM A; 5AYF A; 5T0K A; 3S8P A; 3MO2 A; 3S7D A; 4YNM A; 4E47 A; 3RJW A; 3CBO A; 4Z4P A; 3TG5 A; 3QWV A; 3N71 A; 1MVX A; 1MT6 A; 3MEK A; 4BUP A; 5F6K C; 3F9Z A; 3S7B A; 2BQZ A; 3F9X A; 5JIN A; 2F69 A; 3SWC A; 4IJ8 A; 3OXF A; 3M56 A; 2O8J A; 2R3A A; 2W5Z A; 5LSX A; 4LDG A; 1XQH A; 3RU0 A; 4YND A; 4JDS A; 4O6F A; 5JJ0 A; 3M57 A; 3KMT A; 4NVQ A; 1H3I A; 3F9W A; 4FMU A; 3OXL A; 4QEO A; 4IJD A; 1MVH A; 3M55 A; 5HQ8 A; 3K5K A; 1ZKK A; 2IGQ A; 3OOI A; 4NJ5 A; 1ML9 A; 4C1Q A; 1O9S A; 5F6L A; 5EX0 A; 1MUF A; 4WUY A; 3EP0 A; 5T0M A; 1N6C A; 5HI7 A; 2W5Y A; 4QEN A; 4J8O A; 5KJL A; 3CBM A; 3IHX A; 3RIB A; 4O30 A; #chains in the Genus database with same CATH topology 3S7J A; 4MI0 A; 4MI5 A; 3MO5 A; 4H12 A; 5KJN A; 3VUZ A; 3BO5 A; 4YNP A; 5F59 A; 4YPE A; 3RQ4 A; 2QPW A; 1PEG A; 3QWP A; 3DB5 A; 3HNA A; 3M53 A; 5LSZ A; 5ARF A; 5TTF A; 2G46 A; 3KMA A; 4RZ0 A; 5CPR B; 5KJK A; 3FPD A; 3KMJ A; 3S7F A; 2RFI A; 2JV0 A; 4J7I A; 3OXG A; 5CCL A; 5ARG A; 4QEP A; 3OPE A; 3M59 A; 5EX3 A; 3M5A A; 3F9Y A; 5TEG A; 4YPA A; 3TG4 A; 1N6A A; 5JHN A; 3PDN A; 5KJM A; 3M58 A; 4J83 A; 3SW9 A; 3QWW A; 3MO0 A; 3OS5 A; 4YPU A; 3DAL A; 3VV0 A; 5JIY A; 4AU7 A; 5T5G A; 4J7F A; 4JLG A; 5F5E A; 5EG2 A; 3CBP A; 3M54 A; 4I51 A; 5TH7 A; 1N3J A; 3RAY A; 5CCM A; 5AYF A; 5T0K A; 3S8P A; 3MO2 A; 3S7D A; 4YNM A; 4E47 A; 3RJW A; 3CBO A; 4Z4P A; 3TG5 A; 3QWV A; 3N71 A; 1MVX A; 1MT6 A; 3MEK A; 4BUP A; 5F6K C; 3F9Z A; 3S7B A; 2BQZ A; 3F9X A; 5JIN A; 2F69 A; 3SWC A; 4IJ8 A; 3OXF A; 3M56 A; 2O8J A; 2R3A A; 2W5Z A; 5LSX A; 4LDG A; 1XQH A; 3RU0 A; 4YND A; 4JDS A; 4O6F A; 5JJ0 A; 3M57 A; 3KMT A; 4NVQ A; 1H3I A; 3F9W A; 4FMU A; 3OXL A; 4QEO A; 4IJD A; 1MVH A; 3M55 A; 5HQ8 A; 3K5K A; 1ZKK A; 2IGQ A; 3OOI A; 4NJ5 A; 1ML9 A; 4C1Q A; 1O9S A; 5F6L A; 5EX0 A; 1MUF A; 4WUY A; 3EP0 A; 5T0M A; 1N6C A; 5HI7 A; 2W5Y A; 4QEN A; 4J8O A; 5KJL A; 3CBM A; 3IHX A; 3RIB A; 4O30 A; #chains in the Genus database with same CATH homology 3S7J A; 4MI0 A; 4MI5 A; 3MO5 A; 4H12 A; 5KJN A; 3VUZ A; 3BO5 A; 4YNP A; 5F59 A; 4YPE A; 3RQ4 A; 2QPW A; 1PEG A; 3QWP A; 3DB5 A; 3HNA A; 3M53 A; 5LSZ A; 5ARF A; 5TTF A; 2G46 A; 3KMA A; 4RZ0 A; 5CPR B; 5KJK A; 3FPD A; 3KMJ A; 3S7F A; 2RFI A; 2JV0 A; 4J7I A; 3OXG A; 5CCL A; 5ARG A; 4QEP A; 3OPE A; 3M59 A; 5EX3 A; 3M5A A; 3F9Y A; 5TEG A; 4YPA A; 3TG4 A; 1N6A A; 5JHN A; 3PDN A; 5KJM A; 3M58 A; 4J83 A; 3SW9 A; 3QWW A; 3MO0 A; 3OS5 A; 4YPU A; 3DAL A; 3VV0 A; 5JIY A; 4AU7 A; 5T5G A; 4J7F A; 4JLG A; 5F5E A; 5EG2 A; 3CBP A; 3M54 A; 4I51 A; 5TH7 A; 1N3J A; 3RAY A; 5CCM A; 5AYF A; 5T0K A; 3S8P A; 3MO2 A; 3S7D A; 4YNM A; 4E47 A; 3RJW A; 3CBO A; 4Z4P A; 3TG5 A; 3QWV A; 3N71 A; 1MVX A; 1MT6 A; 3MEK A; 4BUP A; 5F6K C; 3F9Z A; 3S7B A; 2BQZ A; 3F9X A; 5JIN A; 2F69 A; 3SWC A; 4IJ8 A; 3OXF A; 3M56 A; 2O8J A; 2R3A A; 2W5Z A; 5LSX A; 4LDG A; 1XQH A; 3RU0 A; 4YND A; 4JDS A; 4O6F A; 5JJ0 A; 3M57 A; 3KMT A; 4NVQ A; 1H3I A; 3F9W A; 4FMU A; 3OXL A; 4QEO A; 4IJD A; 1MVH A; 3M55 A; 5HQ8 A; 3K5K A; 1ZKK A; 2IGQ A; 3OOI A; 4NJ5 A; 1ML9 A; 4C1Q A; 1O9S A; 5F6L A; 5EX0 A; 1MUF A; 4WUY A; 3EP0 A; 5T0M A; 1N6C A; 5HI7 A; 2W5Y A; 4QEN A; 4J8O A; 5KJL A; 3CBM A; 3IHX A; 3RIB A; 4O30 A;
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