4C1QA

Crystal structure of the prdm9 set domain in complex with h3k4me2 and adohcy.
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
173
structure length
173
Chain Sequence
AMSQDDDYLYCEKCQNFFIDSCPNHGPPLFVKDSMVDRGHPNHSVLSLPPGLRISPSGIPEAGLGVWNEASDLPVGLHFGPYEGQITEDEEAANSGYSWLITKGRNCYEYVDGQDESQANWMRYVNCARDDEEQNLVAFQYHRKIFYRTCRVIRPGCELLVWYGDEYGQELGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of Prdm9.
pubmed doi rcsb
molecule tags Transferase/peptide
source organism Mus musculus
molecule keywords HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9
total genus 43
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4c1qA00
3M54A 4NJ5A 3F9XA 5KJKA 4O6FA 3MO5A 5F6LA 5F6KC 3FPDA 3MO2A 3F9WA 5TH7A 5TTFA 3OOIA 4IJ8A 3TG5A 4I51A 1N6AA 1N3JA 4YNPA 3QWPA 4J8OA 1H3IA 3RU0A 3RIBA 4YPAA 5F5EA 4YNMA 5T5GA 3PDNA 3CBMA 1MUFA 3HNAA 5F59A 2RFIA 3M59A 4YPUA 3KMTA 5EX0A 3VUZA 1PEGA 5KJNA 5JJ0A 3CBOA 4QEOA 3OS5A 5KJLA 1MT6A 3DB5A 4YPEA 5JINA 3M55A 3M56A 4FMUA 5EG2A 3RAYA 3M57A 5TEGA 2W5YA 5ARGA 3EP0A 3OXLA 5CCMA 2F69A 2IGQA 5T0KA 5CPRB 2O8JA 5JIYA 2W5ZA 3F9ZA 3IHXA 3S7FA 3OXGA 4J83A 5EX3A 4BUPA 4C1QA 4RZ0A 3K5KA 4JLGA 5JHNA 3M53A 4QENA 3MEKA 4LDGA 4O30A 4NVQA 5ARFA 4E47A 3OPEA 3QWVA 3QWWA 4AU7A 4Z4PA 3S8PA 3CBPA 3VV0A 4QEPA 4MI5A 1MVXA 2G46A 3TG4A 1N6CA 3S7BA 1XQHA 5CCLA 2BQZA 4YNDA 4J7IA 3N71A 4J7FA 1MVHA 5KJMA 3M5AA 5HI7A 3DALA 5HQ8A 3BO5A 5LSZA 3S7JA 4WUYA 3M58A 5LSXA 3KMJA 4MI0A 4IJDA 3SW9A 3KMAA 2QPWA 1O9SA 3OXFA 3F9YA 5T0MA 1ZKKA 2R3AA 5AYFA 3SWCA 2JV0A 3RQ4A 3S7DA 4H12A 3RJWA 3MO0A 4JDSA 1ML9A
chains in the Genus database with same CATH superfamily
3M54A 4NJ5A 3F9XA 5KJKA 4O6FA 3MO5A 5F6LA 5F6KC 3FPDA 3MO2A 3F9WA 5TH7A 5TTFA 3OOIA 4IJ8A 3TG5A 4I51A 1N6AA 1N3JA 4YNPA 3QWPA 4J8OA 1H3IA 3RU0A 3RIBA 4YPAA 5F5EA 4YNMA 5T5GA 3PDNA 3CBMA 1MUFA 3HNAA 5F59A 2RFIA 3M59A 4YPUA 3KMTA 5EX0A 3VUZA 1PEGA 5KJNA 5JJ0A 3CBOA 4QEOA 3OS5A 5KJLA 1MT6A 3DB5A 4YPEA 5JINA 3M55A 3M56A 4FMUA 5EG2A 3RAYA 3M57A 5TEGA 2W5YA 5ARGA 3EP0A 3OXLA 5CCMA 2F69A 2IGQA 5T0KA 5CPRB 2O8JA 5JIYA 2W5ZA 3F9ZA 3IHXA 3S7FA 3OXGA 4J83A 5EX3A 4BUPA 4C1QA 4RZ0A 3K5KA 4JLGA 5JHNA 3M53A 4QENA 3MEKA 4LDGA 4O30A 4NVQA 5ARFA 4E47A 3OPEA 3QWVA 3QWWA 4AU7A 4Z4PA 3S8PA 3CBPA 3VV0A 4QEPA 4MI5A 1MVXA 2G46A 3TG4A 1N6CA 3S7BA 1XQHA 5CCLA 2BQZA 4YNDA 4J7IA 3N71A 4J7FA 1MVHA 5KJMA 3M5AA 5HI7A 3DALA 5HQ8A 3BO5A 5LSZA 3S7JA 4WUYA 3M58A 5LSXA 3KMJA 4MI0A 4IJDA 3SW9A 3KMAA 2QPWA 1O9SA 3OXFA 3F9YA 5T0MA 1ZKKA 2R3AA 5AYFA 3SWCA 2JV0A 3RQ4A 3S7DA 4H12A 3RJWA 3MO0A 4JDSA 1ML9A
chains in the Genus database with same CATH topology
3M54A 4NJ5A 3F9XA 5KJKA 4O6FA 3MO5A 5F6LA 5F6KC 3FPDA 3MO2A 3F9WA 5TH7A 5TTFA 3OOIA 4IJ8A 3TG5A 4I51A 1N6AA 1N3JA 4YNPA 3QWPA 4J8OA 1H3IA 3RU0A 3RIBA 4YPAA 5F5EA 4YNMA 5T5GA 3PDNA 3CBMA 1MUFA 3HNAA 5F59A 2RFIA 3M59A 4YPUA 3KMTA 5EX0A 3VUZA 1PEGA 5KJNA 5JJ0A 3CBOA 4QEOA 3OS5A 5KJLA 1MT6A 3DB5A 4YPEA 5JINA 3M55A 3M56A 4FMUA 5EG2A 3RAYA 3M57A 5TEGA 2W5YA 5ARGA 3EP0A 3OXLA 5CCMA 2F69A 2IGQA 5T0KA 5CPRB 2O8JA 5JIYA 2W5ZA 3F9ZA 3IHXA 3S7FA 3OXGA 4J83A 5EX3A 4BUPA 4C1QA 4RZ0A 3K5KA 4JLGA 5JHNA 3M53A 4QENA 3MEKA 4LDGA 4O30A 4NVQA 5ARFA 4E47A 3OPEA 3QWVA 3QWWA 4AU7A 4Z4PA 3S8PA 3CBPA 3VV0A 4QEPA 4MI5A 1MVXA 2G46A 3TG4A 1N6CA 3S7BA 1XQHA 5CCLA 2BQZA 4YNDA 4J7IA 3N71A 4J7FA 1MVHA 5KJMA 3M5AA 5HI7A 3DALA 5HQ8A 3BO5A 5LSZA 3S7JA 4WUYA 3M58A 5LSXA 3KMJA 4MI0A 4IJDA 3SW9A 3KMAA 2QPWA 1O9SA 3OXFA 3F9YA 5T0MA 1ZKKA 2R3AA 5AYFA 3SWCA 2JV0A 3RQ4A 3S7DA 4H12A 3RJWA 3MO0A 4JDSA 1ML9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M54 A;  4NJ5 A;  3F9X A;  5KJK A;  4O6F A;  3MO5 A;  5F6L A;  5F6K C;  3FPD A;  3MO2 A;  3F9W A;  5TH7 A;  5TTF A;  3OOI A;  4IJ8 A;  3TG5 A;  4I51 A;  1N6A A;  1N3J A;  4YNP A;  3QWP A;  4J8O A;  1H3I A;  3RU0 A;  3RIB A;  4YPA A;  5F5E A;  4YNM A;  5T5G A;  3PDN A;  3CBM A;  1MUF A;  3HNA A;  5F59 A;  2RFI A;  3M59 A;  4YPU A;  3KMT A;  5EX0 A;  3VUZ A;  1PEG A;  5KJN A;  5JJ0 A;  3CBO A;  4QEO A;  3OS5 A;  5KJL A;  1MT6 A;  3DB5 A;  4YPE A;  5JIN A;  3M55 A;  3M56 A;  4FMU A;  5EG2 A;  3RAY A;  3M57 A;  5TEG A;  2W5Y A;  5ARG A;  3EP0 A;  3OXL A;  5CCM A;  2F69 A;  2IGQ A;  5T0K A;  5CPR B;  2O8J A;  5JIY A;  2W5Z A;  3F9Z A;  3IHX A;  3S7F A;  3OXG A;  4J83 A;  5EX3 A;  4BUP A;  4C1Q A;  4RZ0 A;  3K5K A;  4JLG A;  5JHN A;  3M53 A;  4QEN A;  3MEK A;  4LDG A;  4O30 A;  4NVQ A;  5ARF A;  4E47 A;  3OPE A;  3QWV A;  3QWW A;  4AU7 A;  4Z4P A;  3S8P A;  3CBP A;  3VV0 A;  4QEP A;  4MI5 A;  1MVX A;  2G46 A;  3TG4 A;  1N6C A;  3S7B A;  1XQH A;  5CCL A;  2BQZ A;  4YND A;  4J7I A;  3N71 A;  4J7F A;  1MVH A;  5KJM A;  3M5A A;  5HI7 A;  3DAL A;  5HQ8 A;  3BO5 A;  5LSZ A;  3S7J A;  4WUY A;  3M58 A;  5LSX A;  3KMJ A;  4MI0 A;  4IJD A;  3SW9 A;  3KMA A;  2QPW A;  1O9S A;  3OXF A;  3F9Y A;  5T0M A;  1ZKK A;  2R3A A;  5AYF A;  3SWC A;  2JV0 A;  3RQ4 A;  3S7D A;  4H12 A;  3RJW A;  3MO0 A;  4JDS A;  1ML9 A; 
#chains in the Genus database with same CATH topology
 3M54 A;  4NJ5 A;  3F9X A;  5KJK A;  4O6F A;  3MO5 A;  5F6L A;  5F6K C;  3FPD A;  3MO2 A;  3F9W A;  5TH7 A;  5TTF A;  3OOI A;  4IJ8 A;  3TG5 A;  4I51 A;  1N6A A;  1N3J A;  4YNP A;  3QWP A;  4J8O A;  1H3I A;  3RU0 A;  3RIB A;  4YPA A;  5F5E A;  4YNM A;  5T5G A;  3PDN A;  3CBM A;  1MUF A;  3HNA A;  5F59 A;  2RFI A;  3M59 A;  4YPU A;  3KMT A;  5EX0 A;  3VUZ A;  1PEG A;  5KJN A;  5JJ0 A;  3CBO A;  4QEO A;  3OS5 A;  5KJL A;  1MT6 A;  3DB5 A;  4YPE A;  5JIN A;  3M55 A;  3M56 A;  4FMU A;  5EG2 A;  3RAY A;  3M57 A;  5TEG A;  2W5Y A;  5ARG A;  3EP0 A;  3OXL A;  5CCM A;  2F69 A;  2IGQ A;  5T0K A;  5CPR B;  2O8J A;  5JIY A;  2W5Z A;  3F9Z A;  3IHX A;  3S7F A;  3OXG A;  4J83 A;  5EX3 A;  4BUP A;  4C1Q A;  4RZ0 A;  3K5K A;  4JLG A;  5JHN A;  3M53 A;  4QEN A;  3MEK A;  4LDG A;  4O30 A;  4NVQ A;  5ARF A;  4E47 A;  3OPE A;  3QWV A;  3QWW A;  4AU7 A;  4Z4P A;  3S8P A;  3CBP A;  3VV0 A;  4QEP A;  4MI5 A;  1MVX A;  2G46 A;  3TG4 A;  1N6C A;  3S7B A;  1XQH A;  5CCL A;  2BQZ A;  4YND A;  4J7I A;  3N71 A;  4J7F A;  1MVH A;  5KJM A;  3M5A A;  5HI7 A;  3DAL A;  5HQ8 A;  3BO5 A;  5LSZ A;  3S7J A;  4WUY A;  3M58 A;  5LSX A;  3KMJ A;  4MI0 A;  4IJD A;  3SW9 A;  3KMA A;  2QPW A;  1O9S A;  3OXF A;  3F9Y A;  5T0M A;  1ZKK A;  2R3A A;  5AYF A;  3SWC A;  2JV0 A;  3RQ4 A;  3S7D A;  4H12 A;  3RJW A;  3MO0 A;  4JDS A;  1ML9 A; 
#chains in the Genus database with same CATH homology
 3M54 A;  4NJ5 A;  3F9X A;  5KJK A;  4O6F A;  3MO5 A;  5F6L A;  5F6K C;  3FPD A;  3MO2 A;  3F9W A;  5TH7 A;  5TTF A;  3OOI A;  4IJ8 A;  3TG5 A;  4I51 A;  1N6A A;  1N3J A;  4YNP A;  3QWP A;  4J8O A;  1H3I A;  3RU0 A;  3RIB A;  4YPA A;  5F5E A;  4YNM A;  5T5G A;  3PDN A;  3CBM A;  1MUF A;  3HNA A;  5F59 A;  2RFI A;  3M59 A;  4YPU A;  3KMT A;  5EX0 A;  3VUZ A;  1PEG A;  5KJN A;  5JJ0 A;  3CBO A;  4QEO A;  3OS5 A;  5KJL A;  1MT6 A;  3DB5 A;  4YPE A;  5JIN A;  3M55 A;  3M56 A;  4FMU A;  5EG2 A;  3RAY A;  3M57 A;  5TEG A;  2W5Y A;  5ARG A;  3EP0 A;  3OXL A;  5CCM A;  2F69 A;  2IGQ A;  5T0K A;  5CPR B;  2O8J A;  5JIY A;  2W5Z A;  3F9Z A;  3IHX A;  3S7F A;  3OXG A;  4J83 A;  5EX3 A;  4BUP A;  4C1Q A;  4RZ0 A;  3K5K A;  4JLG A;  5JHN A;  3M53 A;  4QEN A;  3MEK A;  4LDG A;  4O30 A;  4NVQ A;  5ARF A;  4E47 A;  3OPE A;  3QWV A;  3QWW A;  4AU7 A;  4Z4P A;  3S8P A;  3CBP A;  3VV0 A;  4QEP A;  4MI5 A;  1MVX A;  2G46 A;  3TG4 A;  1N6C A;  3S7B A;  1XQH A;  5CCL A;  2BQZ A;  4YND A;  4J7I A;  3N71 A;  4J7F A;  1MVH A;  5KJM A;  3M5A A;  5HI7 A;  3DAL A;  5HQ8 A;  3BO5 A;  5LSZ A;  3S7J A;  4WUY A;  3M58 A;  5LSX A;  3KMJ A;  4MI0 A;  4IJD A;  3SW9 A;  3KMA A;  2QPW A;  1O9S A;  3OXF A;  3F9Y A;  5T0M A;  1ZKK A;  2R3A A;  5AYF A;  3SWC A;  2JV0 A;  3RQ4 A;  3S7D A;  4H12 A;  3RJW A;  3MO0 A;  4JDS A;  1ML9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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