4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
molecule tags Transferase/peptide
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase EHMT1
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
1O9SA 4QEOA 5CPRB 3MEKA 4YNDA 3M53A 3OXFA 5JIYA 3RU0A 3SW9A 3CBMA 5T5GA 5CCMA 4FMUA 5HQ8A 4O6FA 3OXLA 3F9WA 2RFIA 3DB5A 4JLGA 4MI5A 5F59A 4IJ8A 4YPEA 3K5KA 4JDSA 5T0MA 5F5EA 5KJLA 3BO5A 3M59A 3PDNA 4YPUA 4E47A 3OPEA 3F9XA 4YNMA 5KJKA 2W5ZA 2O8JA 4J8OA 4YPAA 4LDGA 5EX3A 4QENA 3M57A 4BUPA 3SWCA 3DALA 3OS5A 1MT6A 1MVHA 3M56A 5F6KC 3RJWA 3RIBA 5EX0A 3IHXA 4Z4PA 4J7IA 4J7FA 3F9YA 3N71A 5JINA 1N6CA 5KJNA 5EG2A 1N6AA 3OXGA 3TG5A 4QEPA 3M58A 1ZKKA 4J83A 3EP0A 1MVXA 3CBPA 3F9ZA 3KMAA 3MO5A 4IJDA 4C1QA 3M5AA 2BQZA 4H12A 3S7FA 1N3JA 4YNPA 1XQHA 5TTFA 2QPWA 4NVQA 4I51A 3M54A 3QWPA 1H3IA 1MUFA 5T0KA 5TEGA 5HI7A 3HNAA 3QWVA 3M55A 5F6LA 3VV0A 5JJ0A 5LSXA 2G46A 2R3AA 4O30A 5ARGA 3CBOA 3S8PA 5KJMA 1PEGA 5TH7A 5ARFA 3S7BA 4RZ0A 3FPDA 3VUZA 4MI0A 4WUYA 5LSZA 3KMJA 5JHNA 2JV0A 3QWWA 3S7JA 2W5YA 3KMTA 2F69A 5CCLA 3MO0A 2IGQA 4NJ5A 3RQ4A 3TG4A 5AYFA 3S7DA 3RAYA 3MO2A 3OOIA 1ML9A 4AU7A
chains in the Genus database with same CATH superfamily
1O9SA 4QEOA 5CPRB 3MEKA 4YNDA 3M53A 3OXFA 5JIYA 3RU0A 3SW9A 3CBMA 5T5GA 5CCMA 4FMUA 5HQ8A 4O6FA 3OXLA 3F9WA 2RFIA 3DB5A 4JLGA 4MI5A 5F59A 4IJ8A 4YPEA 3K5KA 4JDSA 5T0MA 5F5EA 5KJLA 3BO5A 3M59A 3PDNA 4YPUA 4E47A 3OPEA 3F9XA 4YNMA 5KJKA 2W5ZA 2O8JA 4J8OA 4YPAA 4LDGA 5EX3A 4QENA 3M57A 4BUPA 3SWCA 3DALA 3OS5A 1MT6A 1MVHA 3M56A 5F6KC 3RJWA 3RIBA 5EX0A 3IHXA 4Z4PA 4J7IA 4J7FA 3F9YA 3N71A 5JINA 1N6CA 5KJNA 5EG2A 1N6AA 3OXGA 3TG5A 4QEPA 3M58A 1ZKKA 4J83A 3EP0A 1MVXA 3CBPA 3F9ZA 3KMAA 3MO5A 4IJDA 4C1QA 3M5AA 2BQZA 4H12A 3S7FA 1N3JA 4YNPA 1XQHA 5TTFA 2QPWA 4NVQA 4I51A 3M54A 3QWPA 1H3IA 1MUFA 5T0KA 5TEGA 5HI7A 3HNAA 3QWVA 3M55A 5F6LA 3VV0A 5JJ0A 5LSXA 2G46A 2R3AA 4O30A 5ARGA 3CBOA 3S8PA 5KJMA 1PEGA 5TH7A 5ARFA 3S7BA 4RZ0A 3FPDA 3VUZA 4MI0A 4WUYA 5LSZA 3KMJA 5JHNA 2JV0A 3QWWA 3S7JA 2W5YA 3KMTA 2F69A 5CCLA 3MO0A 2IGQA 4NJ5A 3RQ4A 3TG4A 5AYFA 3S7DA 3RAYA 3MO2A 3OOIA 1ML9A 4AU7A
chains in the Genus database with same CATH topology
1O9SA 4QEOA 5CPRB 3MEKA 4YNDA 3M53A 3OXFA 5JIYA 3RU0A 3SW9A 3CBMA 5T5GA 5CCMA 4FMUA 5HQ8A 4O6FA 3OXLA 3F9WA 2RFIA 3DB5A 4JLGA 4MI5A 5F59A 4IJ8A 4YPEA 3K5KA 4JDSA 5T0MA 5F5EA 5KJLA 3BO5A 3M59A 3PDNA 4YPUA 4E47A 3OPEA 3F9XA 4YNMA 5KJKA 2W5ZA 2O8JA 4J8OA 4YPAA 4LDGA 5EX3A 4QENA 3M57A 4BUPA 3SWCA 3DALA 3OS5A 1MT6A 1MVHA 3M56A 5F6KC 3RJWA 3RIBA 5EX0A 3IHXA 4Z4PA 4J7IA 4J7FA 3F9YA 3N71A 5JINA 1N6CA 5KJNA 5EG2A 1N6AA 3OXGA 3TG5A 4QEPA 3M58A 1ZKKA 4J83A 3EP0A 1MVXA 3CBPA 3F9ZA 3KMAA 3MO5A 4IJDA 4C1QA 3M5AA 2BQZA 4H12A 3S7FA 1N3JA 4YNPA 1XQHA 5TTFA 2QPWA 4NVQA 4I51A 3M54A 3QWPA 1H3IA 1MUFA 5T0KA 5TEGA 5HI7A 3HNAA 3QWVA 3M55A 5F6LA 3VV0A 5JJ0A 5LSXA 2G46A 2R3AA 4O30A 5ARGA 3CBOA 3S8PA 5KJMA 1PEGA 5TH7A 5ARFA 3S7BA 4RZ0A 3FPDA 3VUZA 4MI0A 4WUYA 5LSZA 3KMJA 5JHNA 2JV0A 3QWWA 3S7JA 2W5YA 3KMTA 2F69A 5CCLA 3MO0A 2IGQA 4NJ5A 3RQ4A 3TG4A 5AYFA 3S7DA 3RAYA 3MO2A 3OOIA 1ML9A 4AU7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O9S A;  4QEO A;  5CPR B;  3MEK A;  4YND A;  3M53 A;  3OXF A;  5JIY A;  3RU0 A;  3SW9 A;  3CBM A;  5T5G A;  5CCM A;  4FMU A;  5HQ8 A;  4O6F A;  3OXL A;  3F9W A;  2RFI A;  3DB5 A;  4JLG A;  4MI5 A;  5F59 A;  4IJ8 A;  4YPE A;  3K5K A;  4JDS A;  5T0M A;  5F5E A;  5KJL A;  3BO5 A;  3M59 A;  3PDN A;  4YPU A;  4E47 A;  3OPE A;  3F9X A;  4YNM A;  5KJK A;  2W5Z A;  2O8J A;  4J8O A;  4YPA A;  4LDG A;  5EX3 A;  4QEN A;  3M57 A;  4BUP A;  3SWC A;  3DAL A;  3OS5 A;  1MT6 A;  1MVH A;  3M56 A;  5F6K C;  3RJW A;  3RIB A;  5EX0 A;  3IHX A;  4Z4P A;  4J7I A;  4J7F A;  3F9Y A;  3N71 A;  5JIN A;  1N6C A;  5KJN A;  5EG2 A;  1N6A A;  3OXG A;  3TG5 A;  4QEP A;  3M58 A;  1ZKK A;  4J83 A;  3EP0 A;  1MVX A;  3CBP A;  3F9Z A;  3KMA A;  3MO5 A;  4IJD A;  4C1Q A;  3M5A A;  2BQZ A;  4H12 A;  3S7F A;  1N3J A;  4YNP A;  1XQH A;  5TTF A;  2QPW A;  4NVQ A;  4I51 A;  3M54 A;  3QWP A;  1H3I A;  1MUF A;  5T0K A;  5TEG A;  5HI7 A;  3HNA A;  3QWV A;  3M55 A;  5F6L A;  3VV0 A;  5JJ0 A;  5LSX A;  2G46 A;  2R3A A;  4O30 A;  5ARG A;  3CBO A;  3S8P A;  5KJM A;  1PEG A;  5TH7 A;  5ARF A;  3S7B A;  4RZ0 A;  3FPD A;  3VUZ A;  4MI0 A;  4WUY A;  5LSZ A;  3KMJ A;  5JHN A;  2JV0 A;  3QWW A;  3S7J A;  2W5Y A;  3KMT A;  2F69 A;  5CCL A;  3MO0 A;  2IGQ A;  4NJ5 A;  3RQ4 A;  3TG4 A;  5AYF A;  3S7D A;  3RAY A;  3MO2 A;  3OOI A;  1ML9 A;  4AU7 A; 
#chains in the Genus database with same CATH topology
 1O9S A;  4QEO A;  5CPR B;  3MEK A;  4YND A;  3M53 A;  3OXF A;  5JIY A;  3RU0 A;  3SW9 A;  3CBM A;  5T5G A;  5CCM A;  4FMU A;  5HQ8 A;  4O6F A;  3OXL A;  3F9W A;  2RFI A;  3DB5 A;  4JLG A;  4MI5 A;  5F59 A;  4IJ8 A;  4YPE A;  3K5K A;  4JDS A;  5T0M A;  5F5E A;  5KJL A;  3BO5 A;  3M59 A;  3PDN A;  4YPU A;  4E47 A;  3OPE A;  3F9X A;  4YNM A;  5KJK A;  2W5Z A;  2O8J A;  4J8O A;  4YPA A;  4LDG A;  5EX3 A;  4QEN A;  3M57 A;  4BUP A;  3SWC A;  3DAL A;  3OS5 A;  1MT6 A;  1MVH A;  3M56 A;  5F6K C;  3RJW A;  3RIB A;  5EX0 A;  3IHX A;  4Z4P A;  4J7I A;  4J7F A;  3F9Y A;  3N71 A;  5JIN A;  1N6C A;  5KJN A;  5EG2 A;  1N6A A;  3OXG A;  3TG5 A;  4QEP A;  3M58 A;  1ZKK A;  4J83 A;  3EP0 A;  1MVX A;  3CBP A;  3F9Z A;  3KMA A;  3MO5 A;  4IJD A;  4C1Q A;  3M5A A;  2BQZ A;  4H12 A;  3S7F A;  1N3J A;  4YNP A;  1XQH A;  5TTF A;  2QPW A;  4NVQ A;  4I51 A;  3M54 A;  3QWP A;  1H3I A;  1MUF A;  5T0K A;  5TEG A;  5HI7 A;  3HNA A;  3QWV A;  3M55 A;  5F6L A;  3VV0 A;  5JJ0 A;  5LSX A;  2G46 A;  2R3A A;  4O30 A;  5ARG A;  3CBO A;  3S8P A;  5KJM A;  1PEG A;  5TH7 A;  5ARF A;  3S7B A;  4RZ0 A;  3FPD A;  3VUZ A;  4MI0 A;  4WUY A;  5LSZ A;  3KMJ A;  5JHN A;  2JV0 A;  3QWW A;  3S7J A;  2W5Y A;  3KMT A;  2F69 A;  5CCL A;  3MO0 A;  2IGQ A;  4NJ5 A;  3RQ4 A;  3TG4 A;  5AYF A;  3S7D A;  3RAY A;  3MO2 A;  3OOI A;  1ML9 A;  4AU7 A; 
#chains in the Genus database with same CATH homology
 1O9S A;  4QEO A;  5CPR B;  3MEK A;  4YND A;  3M53 A;  3OXF A;  5JIY A;  3RU0 A;  3SW9 A;  3CBM A;  5T5G A;  5CCM A;  4FMU A;  5HQ8 A;  4O6F A;  3OXL A;  3F9W A;  2RFI A;  3DB5 A;  4JLG A;  4MI5 A;  5F59 A;  4IJ8 A;  4YPE A;  3K5K A;  4JDS A;  5T0M A;  5F5E A;  5KJL A;  3BO5 A;  3M59 A;  3PDN A;  4YPU A;  4E47 A;  3OPE A;  3F9X A;  4YNM A;  5KJK A;  2W5Z A;  2O8J A;  4J8O A;  4YPA A;  4LDG A;  5EX3 A;  4QEN A;  3M57 A;  4BUP A;  3SWC A;  3DAL A;  3OS5 A;  1MT6 A;  1MVH A;  3M56 A;  5F6K C;  3RJW A;  3RIB A;  5EX0 A;  3IHX A;  4Z4P A;  4J7I A;  4J7F A;  3F9Y A;  3N71 A;  5JIN A;  1N6C A;  5KJN A;  5EG2 A;  1N6A A;  3OXG A;  3TG5 A;  4QEP A;  3M58 A;  1ZKK A;  4J83 A;  3EP0 A;  1MVX A;  3CBP A;  3F9Z A;  3KMA A;  3MO5 A;  4IJD A;  4C1Q A;  3M5A A;  2BQZ A;  4H12 A;  3S7F A;  1N3J A;  4YNP A;  1XQH A;  5TTF A;  2QPW A;  4NVQ A;  4I51 A;  3M54 A;  3QWP A;  1H3I A;  1MUF A;  5T0K A;  5TEG A;  5HI7 A;  3HNA A;  3QWV A;  3M55 A;  5F6L A;  3VV0 A;  5JJ0 A;  5LSX A;  2G46 A;  2R3A A;  4O30 A;  5ARG A;  3CBO A;  3S8P A;  5KJM A;  1PEG A;  5TH7 A;  5ARF A;  3S7B A;  4RZ0 A;  3FPD A;  3VUZ A;  4MI0 A;  4WUY A;  5LSZ A;  3KMJ A;  5JHN A;  2JV0 A;  3QWW A;  3S7J A;  2W5Y A;  3KMT A;  2F69 A;  5CCL A;  3MO0 A;  2IGQ A;  4NJ5 A;  3RQ4 A;  3TG4 A;  5AYF A;  3S7D A;  3RAY A;  3MO2 A;  3OOI A;  1ML9 A;  4AU7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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