The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
34
|
sequence length |
143
|
structure length |
143
|
Chain Sequence |
SKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKSGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
pubmed doi rcsb |
| molecule keywords |
N-lysine methyltransferase KMT5A
|
| molecule tags |
Transferase/transferase inhibitor
|
| source organism |
Homo sapiens
|
| total genus |
34
|
| structure length |
143
|
| sequence length |
143
|
| ec nomenclature |
ec
2.1.1.43: Histone-lysine N-methyltransferase. |
| pdb deposition date | 2016-08-30 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00856 | SET | SET domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Beta Complex | Beta-clip-like | SET domain |
#chains in the Genus database with same CATH superfamily 4YNM A; 2G46 A; 4QEN A; 1O9S A; 1N6C A; 4YNP A; 5F59 A; 3MEK A; 3M58 A; 5KJK A; 5TEG A; 3QWV A; 3MO5 A; 4RZ0 A; 3KMT A; 4J7F A; 3S8P A; 3S7J A; 5T0K A; 3KMJ A; 4YPU A; 1MT6 A; 5CCM A; 2BQZ A; 4NJ5 A; 5EX3 A; 5EX0 A; 4QEP A; 3RU0 A; 3F9X A; 5HQ8 A; 4I51 A; 3M56 A; 5CPR B; 3VV0 A; 4J83 A; 5ARF A; 5JJ0 A; 5KJN A; 3RIB A; 3OXG A; 3M57 A; 3VUZ A; 3FPD A; 1ZKK A; 3TG4 A; 4O6F A; 5T0M A; 3M5A A; 3S7D A; 4E47 A; 5F6L A; 2O8J A; 5HI7 A; 4WUY A; 4AU7 A; 3BO5 A; 3S7B A; 3EP0 A; 3MO0 A; 5KJL A; 3QWP A; 2W5Y A; 3OXF A; 3DB5 A; 3PDN A; 3RQ4 A; 3SW9 A; 4J7I A; 1MVX A; 5LSX A; 1XQH A; 4LDG A; 3OS5 A; 3N71 A; 5T5G A; 4YPE A; 5TTF A; 1H3I A; 3IHX A; 4YPA A; 3DAL A; 5LSZ A; 1ML9 A; 2R3A A; 3OXL A; 4BUP A; 3RJW A; 4MI5 A; 3F9W A; 3M54 A; 5JIN A; 3QWW A; 1MVH A; 3MO2 A; 2JV0 A; 4MI0 A; 3CBO A; 5TH7 A; 3HNA A; 1PEG A; 3M53 A; 3TG5 A; 2IGQ A; 2RFI A; 4O30 A; 3M55 A; 3OOI A; 3RAY A; 4QEO A; 4H12 A; 3K5K A; 4IJ8 A; 5CCL A; 5AYF A; 5KJM A; 5F5E A; 1MUF A; 5JIY A; 4JDS A; 3F9Y A; 5JHN A; 3KMA A; 3OPE A; 4FMU A; 4NVQ A; 4J8O A; 5EG2 A; 3F9Z A; 4C1Q A; 4IJD A; 4YND A; 1N3J A; 2F69 A; 3M59 A; 3SWC A; 3CBP A; 1N6A A; 4JLG A; 4Z4P A; 3CBM A; 5ARG A; 5F6K C; 2W5Z A; 2QPW A; 3S7F A; #chains in the Genus database with same CATH topology 4YNM A; 2G46 A; 4QEN A; 1O9S A; 1N6C A; 4YNP A; 5F59 A; 3MEK A; 3M58 A; 5KJK A; 5TEG A; 3QWV A; 3MO5 A; 4RZ0 A; 3KMT A; 4J7F A; 3S8P A; 3S7J A; 5T0K A; 3KMJ A; 4YPU A; 1MT6 A; 5CCM A; 2BQZ A; 4NJ5 A; 5EX3 A; 5EX0 A; 4QEP A; 3RU0 A; 3F9X A; 5HQ8 A; 4I51 A; 3M56 A; 5CPR B; 3VV0 A; 4J83 A; 5ARF A; 5JJ0 A; 5KJN A; 3RIB A; 3OXG A; 3M57 A; 3VUZ A; 3FPD A; 1ZKK A; 3TG4 A; 4O6F A; 5T0M A; 3M5A A; 3S7D A; 4E47 A; 5F6L A; 2O8J A; 5HI7 A; 4WUY A; 4AU7 A; 3BO5 A; 3S7B A; 3EP0 A; 3MO0 A; 5KJL A; 3QWP A; 2W5Y A; 3OXF A; 3DB5 A; 3PDN A; 3RQ4 A; 3SW9 A; 4J7I A; 1MVX A; 5LSX A; 1XQH A; 4LDG A; 3OS5 A; 3N71 A; 5T5G A; 4YPE A; 5TTF A; 1H3I A; 3IHX A; 4YPA A; 3DAL A; 5LSZ A; 1ML9 A; 2R3A A; 3OXL A; 4BUP A; 3RJW A; 4MI5 A; 3F9W A; 3M54 A; 5JIN A; 3QWW A; 1MVH A; 3MO2 A; 2JV0 A; 4MI0 A; 3CBO A; 5TH7 A; 3HNA A; 1PEG A; 3M53 A; 3TG5 A; 2IGQ A; 2RFI A; 4O30 A; 3M55 A; 3OOI A; 3RAY A; 4QEO A; 4H12 A; 3K5K A; 4IJ8 A; 5CCL A; 5AYF A; 5KJM A; 5F5E A; 1MUF A; 5JIY A; 4JDS A; 3F9Y A; 5JHN A; 3KMA A; 3OPE A; 4FMU A; 4NVQ A; 4J8O A; 5EG2 A; 3F9Z A; 4C1Q A; 4IJD A; 4YND A; 1N3J A; 2F69 A; 3M59 A; 3SWC A; 3CBP A; 1N6A A; 4JLG A; 4Z4P A; 3CBM A; 5ARG A; 5F6K C; 2W5Z A; 2QPW A; 3S7F A; #chains in the Genus database with same CATH homology 4YNM A; 2G46 A; 4QEN A; 1O9S A; 1N6C A; 4YNP A; 5F59 A; 3MEK A; 3M58 A; 5KJK A; 5TEG A; 3QWV A; 3MO5 A; 4RZ0 A; 3KMT A; 4J7F A; 3S8P A; 3S7J A; 5T0K A; 3KMJ A; 4YPU A; 1MT6 A; 5CCM A; 2BQZ A; 4NJ5 A; 5EX3 A; 5EX0 A; 4QEP A; 3RU0 A; 3F9X A; 5HQ8 A; 4I51 A; 3M56 A; 5CPR B; 3VV0 A; 4J83 A; 5ARF A; 5JJ0 A; 5KJN A; 3RIB A; 3OXG A; 3M57 A; 3VUZ A; 3FPD A; 1ZKK A; 3TG4 A; 4O6F A; 5T0M A; 3M5A A; 3S7D A; 4E47 A; 5F6L A; 2O8J A; 5HI7 A; 4WUY A; 4AU7 A; 3BO5 A; 3S7B A; 3EP0 A; 3MO0 A; 5KJL A; 3QWP A; 2W5Y A; 3OXF A; 3DB5 A; 3PDN A; 3RQ4 A; 3SW9 A; 4J7I A; 1MVX A; 5LSX A; 1XQH A; 4LDG A; 3OS5 A; 3N71 A; 5T5G A; 4YPE A; 5TTF A; 1H3I A; 3IHX A; 4YPA A; 3DAL A; 5LSZ A; 1ML9 A; 2R3A A; 3OXL A; 4BUP A; 3RJW A; 4MI5 A; 3F9W A; 3M54 A; 5JIN A; 3QWW A; 1MVH A; 3MO2 A; 2JV0 A; 4MI0 A; 3CBO A; 5TH7 A; 3HNA A; 1PEG A; 3M53 A; 3TG5 A; 2IGQ A; 2RFI A; 4O30 A; 3M55 A; 3OOI A; 3RAY A; 4QEO A; 4H12 A; 3K5K A; 4IJ8 A; 5CCL A; 5AYF A; 5KJM A; 5F5E A; 1MUF A; 5JIY A; 4JDS A; 3F9Y A; 5JHN A; 3KMA A; 3OPE A; 4FMU A; 4NVQ A; 4J8O A; 5EG2 A; 3F9Z A; 4C1Q A; 4IJD A; 4YND A; 1N3J A; 2F69 A; 3M59 A; 3SWC A; 3CBP A; 1N6A A; 4JLG A; 4Z4P A; 3CBM A; 5ARG A; 5F6K C; 2W5Z A; 2QPW A; 3S7F A;
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