5F5EA

The crystal structure of mll1 set domain with n3816i/q3867l mutation
Total Genus 40
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
156
structure length
148
Chain Sequence
LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGIVIRSILTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKKLPCNCGAKKCRKFLN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for activity regulation of MLL family methyltransferases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase 2A
total genus 40
structure length 148
sequence length 156
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2015-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5f5eA00
3M58A 5KJNA 1O9SA 3TG5A 3OS5A 3VUZA 3MO2A 4MI5A 5CCLA 5EX0A 3DALA 5HQ8A 5KJKA 2O8JA 2R3AA 3CBPA 3S7DA 4IJDA 1MT6A 4J7FA 3OOIA 4QENA 1N6CA 1H3IA 4YPUA 5T0MA 4IJ8A 3DB5A 3FPDA 4JLGA 5JJ0A 3M57A 5TEGA 4H12A 5EX3A 3HNAA 3M59A 3MEKA 3K5KA 3M54A 3TG4A 2F69A 3S7JA 4Z4PA 5CPRB 5EG2A 3KMJA 2W5YA 5LSXA 3OXLA 5TTFA 5F59A 3F9YA 1XQHA 2G46A 3SWCA 3RJWA 4YNPA 2IGQA 1ML9A 3F9XA 4JDSA 1MUFA 3IHXA 4QEPA 3M53A 4RZ0A 5ARGA 5ARFA 4I51A 4LDGA 1ZKKA 3RU0A 5KJMA 4E47A 3N71A 4YPAA 4YPEA 3QWVA 2JV0A 1PEGA 3VV0A 3F9WA 4YNMA 5F6KC 4QEOA 3SW9A 3M55A 4FMUA 5JHNA 5F5EA 3OXFA 2RFIA 3M56A 4O6FA 4AU7A 1N6AA 3EP0A 4J83A 3QWPA 4NJ5A 3BO5A 2QPWA 5KJLA 3QWWA 4NVQA 5CCMA 5JIYA 5T5GA 3CBOA 4WUYA 5T0KA 5F6LA 3CBMA 5LSZA 3S7BA 5TH7A 3RQ4A 1MVHA 2BQZA 4J8OA 5AYFA 3S7FA 5HI7A 4C1QA 3RIBA 3F9ZA 3PDNA 3S8PA 4BUPA 1MVXA 3KMTA 3MO5A 3M5AA 3OPEA 3OXGA 4J7IA 2W5ZA 4YNDA 3KMAA 3RAYA 1N3JA 3MO0A 4O30A 4MI0A 5JINA
chains in the Genus database with same CATH superfamily
3M58A 5KJNA 1O9SA 3TG5A 3OS5A 3VUZA 3MO2A 4MI5A 5CCLA 5EX0A 3DALA 5HQ8A 5KJKA 2O8JA 2R3AA 3CBPA 3S7DA 4IJDA 1MT6A 4J7FA 3OOIA 4QENA 1N6CA 1H3IA 4YPUA 5T0MA 4IJ8A 3DB5A 3FPDA 4JLGA 5JJ0A 3M57A 5TEGA 4H12A 5EX3A 3HNAA 3M59A 3MEKA 3K5KA 3M54A 3TG4A 2F69A 3S7JA 4Z4PA 5CPRB 5EG2A 3KMJA 2W5YA 5LSXA 3OXLA 5TTFA 5F59A 3F9YA 1XQHA 2G46A 3SWCA 3RJWA 4YNPA 2IGQA 1ML9A 3F9XA 4JDSA 1MUFA 3IHXA 4QEPA 3M53A 4RZ0A 5ARGA 5ARFA 4I51A 4LDGA 1ZKKA 3RU0A 5KJMA 4E47A 3N71A 4YPAA 4YPEA 3QWVA 2JV0A 1PEGA 3VV0A 3F9WA 4YNMA 5F6KC 4QEOA 3SW9A 3M55A 4FMUA 5JHNA 5F5EA 3OXFA 2RFIA 3M56A 4O6FA 4AU7A 1N6AA 3EP0A 4J83A 3QWPA 4NJ5A 3BO5A 2QPWA 5KJLA 3QWWA 4NVQA 5CCMA 5JIYA 5T5GA 3CBOA 4WUYA 5T0KA 5F6LA 3CBMA 5LSZA 3S7BA 5TH7A 3RQ4A 1MVHA 2BQZA 4J8OA 5AYFA 3S7FA 5HI7A 4C1QA 3RIBA 3F9ZA 3PDNA 3S8PA 4BUPA 1MVXA 3KMTA 3MO5A 3M5AA 3OPEA 3OXGA 4J7IA 2W5ZA 4YNDA 3KMAA 3RAYA 1N3JA 3MO0A 4O30A 4MI0A 5JINA
chains in the Genus database with same CATH topology
3M58A 5KJNA 1O9SA 3TG5A 3OS5A 3VUZA 3MO2A 4MI5A 5CCLA 5EX0A 3DALA 5HQ8A 5KJKA 2O8JA 2R3AA 3CBPA 3S7DA 4IJDA 1MT6A 4J7FA 3OOIA 4QENA 1N6CA 1H3IA 4YPUA 5T0MA 4IJ8A 3DB5A 3FPDA 4JLGA 5JJ0A 3M57A 5TEGA 4H12A 5EX3A 3HNAA 3M59A 3MEKA 3K5KA 3M54A 3TG4A 2F69A 3S7JA 4Z4PA 5CPRB 5EG2A 3KMJA 2W5YA 5LSXA 3OXLA 5TTFA 5F59A 3F9YA 1XQHA 2G46A 3SWCA 3RJWA 4YNPA 2IGQA 1ML9A 3F9XA 4JDSA 1MUFA 3IHXA 4QEPA 3M53A 4RZ0A 5ARGA 5ARFA 4I51A 4LDGA 1ZKKA 3RU0A 5KJMA 4E47A 3N71A 4YPAA 4YPEA 3QWVA 2JV0A 1PEGA 3VV0A 3F9WA 4YNMA 5F6KC 4QEOA 3SW9A 3M55A 4FMUA 5JHNA 5F5EA 3OXFA 2RFIA 3M56A 4O6FA 4AU7A 1N6AA 3EP0A 4J83A 3QWPA 4NJ5A 3BO5A 2QPWA 5KJLA 3QWWA 4NVQA 5CCMA 5JIYA 5T5GA 3CBOA 4WUYA 5T0KA 5F6LA 3CBMA 5LSZA 3S7BA 5TH7A 3RQ4A 1MVHA 2BQZA 4J8OA 5AYFA 3S7FA 5HI7A 4C1QA 3RIBA 3F9ZA 3PDNA 3S8PA 4BUPA 1MVXA 3KMTA 3MO5A 3M5AA 3OPEA 3OXGA 4J7IA 2W5ZA 4YNDA 3KMAA 3RAYA 1N3JA 3MO0A 4O30A 4MI0A 5JINA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M58 A;  5KJN A;  1O9S A;  3TG5 A;  3OS5 A;  3VUZ A;  3MO2 A;  4MI5 A;  5CCL A;  5EX0 A;  3DAL A;  5HQ8 A;  5KJK A;  2O8J A;  2R3A A;  3CBP A;  3S7D A;  4IJD A;  1MT6 A;  4J7F A;  3OOI A;  4QEN A;  1N6C A;  1H3I A;  4YPU A;  5T0M A;  4IJ8 A;  3DB5 A;  3FPD A;  4JLG A;  5JJ0 A;  3M57 A;  5TEG A;  4H12 A;  5EX3 A;  3HNA A;  3M59 A;  3MEK A;  3K5K A;  3M54 A;  3TG4 A;  2F69 A;  3S7J A;  4Z4P A;  5CPR B;  5EG2 A;  3KMJ A;  2W5Y A;  5LSX A;  3OXL A;  5TTF A;  5F59 A;  3F9Y A;  1XQH A;  2G46 A;  3SWC A;  3RJW A;  4YNP A;  2IGQ A;  1ML9 A;  3F9X A;  4JDS A;  1MUF A;  3IHX A;  4QEP A;  3M53 A;  4RZ0 A;  5ARG A;  5ARF A;  4I51 A;  4LDG A;  1ZKK A;  3RU0 A;  5KJM A;  4E47 A;  3N71 A;  4YPA A;  4YPE A;  3QWV A;  2JV0 A;  1PEG A;  3VV0 A;  3F9W A;  4YNM A;  5F6K C;  4QEO A;  3SW9 A;  3M55 A;  4FMU A;  5JHN A;  5F5E A;  3OXF A;  2RFI A;  3M56 A;  4O6F A;  4AU7 A;  1N6A A;  3EP0 A;  4J83 A;  3QWP A;  4NJ5 A;  3BO5 A;  2QPW A;  5KJL A;  3QWW A;  4NVQ A;  5CCM A;  5JIY A;  5T5G A;  3CBO A;  4WUY A;  5T0K A;  5F6L A;  3CBM A;  5LSZ A;  3S7B A;  5TH7 A;  3RQ4 A;  1MVH A;  2BQZ A;  4J8O A;  5AYF A;  3S7F A;  5HI7 A;  4C1Q A;  3RIB A;  3F9Z A;  3PDN A;  3S8P A;  4BUP A;  1MVX A;  3KMT A;  3MO5 A;  3M5A A;  3OPE A;  3OXG A;  4J7I A;  2W5Z A;  4YND A;  3KMA A;  3RAY A;  1N3J A;  3MO0 A;  4O30 A;  4MI0 A;  5JIN A; 
#chains in the Genus database with same CATH topology
 3M58 A;  5KJN A;  1O9S A;  3TG5 A;  3OS5 A;  3VUZ A;  3MO2 A;  4MI5 A;  5CCL A;  5EX0 A;  3DAL A;  5HQ8 A;  5KJK A;  2O8J A;  2R3A A;  3CBP A;  3S7D A;  4IJD A;  1MT6 A;  4J7F A;  3OOI A;  4QEN A;  1N6C A;  1H3I A;  4YPU A;  5T0M A;  4IJ8 A;  3DB5 A;  3FPD A;  4JLG A;  5JJ0 A;  3M57 A;  5TEG A;  4H12 A;  5EX3 A;  3HNA A;  3M59 A;  3MEK A;  3K5K A;  3M54 A;  3TG4 A;  2F69 A;  3S7J A;  4Z4P A;  5CPR B;  5EG2 A;  3KMJ A;  2W5Y A;  5LSX A;  3OXL A;  5TTF A;  5F59 A;  3F9Y A;  1XQH A;  2G46 A;  3SWC A;  3RJW A;  4YNP A;  2IGQ A;  1ML9 A;  3F9X A;  4JDS A;  1MUF A;  3IHX A;  4QEP A;  3M53 A;  4RZ0 A;  5ARG A;  5ARF A;  4I51 A;  4LDG A;  1ZKK A;  3RU0 A;  5KJM A;  4E47 A;  3N71 A;  4YPA A;  4YPE A;  3QWV A;  2JV0 A;  1PEG A;  3VV0 A;  3F9W A;  4YNM A;  5F6K C;  4QEO A;  3SW9 A;  3M55 A;  4FMU A;  5JHN A;  5F5E A;  3OXF A;  2RFI A;  3M56 A;  4O6F A;  4AU7 A;  1N6A A;  3EP0 A;  4J83 A;  3QWP A;  4NJ5 A;  3BO5 A;  2QPW A;  5KJL A;  3QWW A;  4NVQ A;  5CCM A;  5JIY A;  5T5G A;  3CBO A;  4WUY A;  5T0K A;  5F6L A;  3CBM A;  5LSZ A;  3S7B A;  5TH7 A;  3RQ4 A;  1MVH A;  2BQZ A;  4J8O A;  5AYF A;  3S7F A;  5HI7 A;  4C1Q A;  3RIB A;  3F9Z A;  3PDN A;  3S8P A;  4BUP A;  1MVX A;  3KMT A;  3MO5 A;  3M5A A;  3OPE A;  3OXG A;  4J7I A;  2W5Z A;  4YND A;  3KMA A;  3RAY A;  1N3J A;  3MO0 A;  4O30 A;  4MI0 A;  5JIN A; 
#chains in the Genus database with same CATH homology
 3M58 A;  5KJN A;  1O9S A;  3TG5 A;  3OS5 A;  3VUZ A;  3MO2 A;  4MI5 A;  5CCL A;  5EX0 A;  3DAL A;  5HQ8 A;  5KJK A;  2O8J A;  2R3A A;  3CBP A;  3S7D A;  4IJD A;  1MT6 A;  4J7F A;  3OOI A;  4QEN A;  1N6C A;  1H3I A;  4YPU A;  5T0M A;  4IJ8 A;  3DB5 A;  3FPD A;  4JLG A;  5JJ0 A;  3M57 A;  5TEG A;  4H12 A;  5EX3 A;  3HNA A;  3M59 A;  3MEK A;  3K5K A;  3M54 A;  3TG4 A;  2F69 A;  3S7J A;  4Z4P A;  5CPR B;  5EG2 A;  3KMJ A;  2W5Y A;  5LSX A;  3OXL A;  5TTF A;  5F59 A;  3F9Y A;  1XQH A;  2G46 A;  3SWC A;  3RJW A;  4YNP A;  2IGQ A;  1ML9 A;  3F9X A;  4JDS A;  1MUF A;  3IHX A;  4QEP A;  3M53 A;  4RZ0 A;  5ARG A;  5ARF A;  4I51 A;  4LDG A;  1ZKK A;  3RU0 A;  5KJM A;  4E47 A;  3N71 A;  4YPA A;  4YPE A;  3QWV A;  2JV0 A;  1PEG A;  3VV0 A;  3F9W A;  4YNM A;  5F6K C;  4QEO A;  3SW9 A;  3M55 A;  4FMU A;  5JHN A;  5F5E A;  3OXF A;  2RFI A;  3M56 A;  4O6F A;  4AU7 A;  1N6A A;  3EP0 A;  4J83 A;  3QWP A;  4NJ5 A;  3BO5 A;  2QPW A;  5KJL A;  3QWW A;  4NVQ A;  5CCM A;  5JIY A;  5T5G A;  3CBO A;  4WUY A;  5T0K A;  5F6L A;  3CBM A;  5LSZ A;  3S7B A;  5TH7 A;  3RQ4 A;  1MVH A;  2BQZ A;  4J8O A;  5AYF A;  3S7F A;  5HI7 A;  4C1Q A;  3RIB A;  3F9Z A;  3PDN A;  3S8P A;  4BUP A;  1MVX A;  3KMT A;  3MO5 A;  3M5A A;  3OPE A;  3OXG A;  4J7I A;  2W5Z A;  4YND A;  3KMA A;  3RAY A;  1N3J A;  3MO0 A;  4O30 A;  4MI0 A;  5JIN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...