4J7HA

Crystal structure of evaa, a 2,3-dehydratase in complex with dtdp-benzene and dtdp-rhamnose
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
Knots found
sequence length
458
structure length
446
Chain Sequence
AVRPRDHHDYADRIALSAATTDGVQMRTEDVRAWIAERRDANVFHVERIPFADLDQWWFEGVTGNLVHRSGRFFTIEGLHVIEHDGPHGDGPYREWQQPVIRQPEVGILGILAKEFDGVLHFLMQAKMEPGNPNLVQLSPTVQATRSNYNVKLIEYFAPPDPERVIVDVLQAEQGSWFFRKSNRNMIVETVDDVPLWDDFCWLTLGQIAELMHEDETINMNSRSVLSCLPYQDITPRALFSDVQLLSWFTNERSRHDVRVRRIPLADVCGWKQGAEEIEHEDGRYFKVLAVAVKKISWTQPLVESVDLGVVAFLVRKIDGVPHVLVQARVDGGFLDTVELAPTVQCTPLNYAHLPAEEAPPFLDLVQNAPRSRIRYEAIHSEEGGRFLGVRARYLVIDADEAIDPPPGYAWVTPAQLTALTRHGHYVNVEARTLLACINAAAAQPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords EvaA 2,3-dehydratase
publication title Structure of EvaA: A Paradigm for Sugar 2,3-Dehydratases.
pubmed doi rcsb
source organism Amycolatopsis orientalis
molecule tags Biosynthetic protein
total genus 141
structure length 446
sequence length 458
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 4.2.1.159: dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase.
pdb deposition date 2013-02-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03559 Hexose_dehydrat NDP-hexose 2,3-dehydratase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.79.40 Alpha Beta Alpha-Beta Complex Nucleoside Triphosphate Pyrophosphohydrolase Nucleoside Triphosphate Pyrophosphohydrolase 4j7hA02
4J7GA 4J7HA
chains in the Genus database with same CATH superfamily
3ZR1A 1NQZA 3DKUA 5BS6A 3P6YA 2PNYA 1PPWA 1V8UA 3X0OA 1VRLA 1TUMA 4NFXA 5C8LA 1Q54A 3ZR0A 4DYWA 3MGMA 3A6UA 1VCDA 3BM4A 2VNQA 5GHPA 3EEUA 3N77A 4MPOA 2YVMA 1SU2A 1VC9A 2A8RA 3FK9A 3Q2SA 3Q91A 3J7Ye 4HVYA 2DSDA 2GB5A 3BAPA 3FJYA 1V8IA 1HZTA 2FMLA 2G74A 2A8PA 2ICJA 4KG4A 4IJXA 1RRQA 1NQYA 3BHOA 1NFSA 1VHZA 2I8UA 2QKMB 4J7GA 4N1UA 1U20A 1KTGA 1SJYA 5ANVA 3R03A 3HHJA 2A8QA 1HX3A 1V8SA 3MDIA 2DSCA 1SZ3A 2XSQA 3ACAA 3Q2TA 2KDVA 1V8TA 1X51A 4JZSA 3HYQA 1G0SA 3O52A 5DEQA 3Q93A 5DDGA 3GZ5A 3X0LA 1PVFA 5DD4A 1RYAA 3N9UA 1G9QA 5ANUA 1IRYA 5HZXA 1V8NA 2A8SA 2B06A 5GHIA 4C9WA 1MP2A 3A6SA 4S2WA 1RRSA 5CFJA 3FCMA 1V8YA 2ICKA 2GT2A 3OGAA 1JRKA 1KT9A 4S2XA 4JZVA 3E57A 3SONA 3A6VA 1VIQA 2CL3A 1V8LA 1VHGA 4ILQA 5DPKA 1MQEA 3P5TA 2FKBA 3FFUA 3X0MA 4NFWA 1F3YA 5I8UA 3U53A 1K26A 3RH7A 5FSIA 1R67A 1XSAA 3A6TA 3EESA 5FSKA 5FSOA 1MUTA 3Q4IA 3H95A 5ANWA 4YOQA 2O1CA 3GZ8A 1QVJA 5GHNA 5GHMA 2QJTA 2DSBA 2GT4A 3GWYA 4JZTA 3O69A 4YPRA 5CFIA 5C7QA 3CNGA 3F13A 3I9XA 2AZWA 3I7VA 1PPXA 4KYXA 5GHJA 4ZG0A 3KVHA 5LPGA 3X0NA 4ICKA 1PPVA 3F6AA 1VK6A 3QSJA 2I8TA 2B0VA 4S2VA 1KHZA 2I6KA 4YPHA 2VNPA 2QJOA 3FSPA 2DUKA 3EF5A 2YYHA 1K2EA 1PUSA 2O5WA 2YVPA 1V8WA 2W4EA 5GHQA 1OW2A 3EXQA 5ANTA 3X0PA 2A8TA 1MR2A 5GHOA 3X0IA 3WHWA 5ISYA 3O8SA 1VIUA 2PQVA 4KG3A 5FSMA 3GRNA 3X0SA 1JKNA 1MK1A 1Q27A 2R5WA 3ID9A 3O6ZA 1NFZA 1XSCA 4C9XA 3GG6A 4JZUA 3X0JA 3SMDA 2A6TA 2DHOA 3G0QA 2JVBA 3MCFA 4KTBA 4V14A 1VC8A 1SOIA 2RRKA 1X84A 5C7TA 3DUPA 1V8VA 2KDWA 2YVNA 1V8MA 2O5FA 3L85A 3SHDA 5BONA 1I9AA 1V8RA 3Q1PA 4K6EA 4HFQA 1Q33A 1PUNA 1XSBA 2FVVA 3O61A 5FSLA 4S2YA 3GZ6A 1MQWA 4N1TA 2B2KA 5FSNA 2G73A 2YVOA 3AC9A 3X0KA 1GA7A 3I7UA 3X0QA 5ANSA 4J7HA 2CZRA 1X83A 3COUA 3X0RA 5IW5A 1PUQA 2J8QA 2Q9PA 3MDGA 5IW4A
chains in the Genus database with same CATH topology
3ZR1A 1NQZA 3DKUA 5BS6A 3P6YA 2PNYA 1PPWA 1V8UA 3X0OA 1VRLA 1TUMA 4NFXA 5C8LA 1Q54A 3ZR0A 4DYWA 3MGMA 3A6UA 1VCDA 3BM4A 2VNQA 5GHPA 3EEUA 3N77A 4MPOA 2YVMA 1SU2A 1VC9A 2A8RA 3FK9A 3Q2SA 3Q91A 3J7Ye 4HVYA 2DSDA 2GB5A 3BAPA 3FJYA 1V8IA 1HZTA 2FMLA 2G74A 2A8PA 2ICJA 4KG4A 4IJXA 1RRQA 1NQYA 3BHOA 1NFSA 1VHZA 2I8UA 2QKMB 4J7GA 4N1UA 1U20A 1KTGA 1SJYA 5ANVA 3R03A 3HHJA 2A8QA 1HX3A 1V8SA 3MDIA 2DSCA 1SZ3A 2XSQA 3ACAA 3Q2TA 2KDVA 1V8TA 1X51A 4JZSA 3HYQA 1G0SA 3O52A 5DEQA 3Q93A 5DDGA 3GZ5A 3X0LA 1PVFA 5DD4A 1RYAA 3N9UA 1G9QA 5ANUA 1IRYA 5HZXA 1V8NA 2A8SA 2B06A 5GHIA 4C9WA 1MP2A 3A6SA 4S2WA 1RRSA 5CFJA 3FCMA 1V8YA 2ICKA 2GT2A 3OGAA 1JRKA 1KT9A 4S2XA 4JZVA 3E57A 3SONA 3A6VA 1VIQA 2CL3A 1V8LA 1VHGA 4ILQA 5DPKA 1MQEA 3P5TA 2FKBA 3FFUA 3X0MA 4NFWA 1F3YA 5I8UA 3U53A 1K26A 3RH7A 5FSIA 1R67A 1XSAA 3A6TA 3EESA 5FSKA 5FSOA 1MUTA 3Q4IA 3H95A 5ANWA 4YOQA 2O1CA 3GZ8A 1QVJA 5GHNA 5GHMA 2QJTA 2DSBA 2GT4A 3GWYA 4JZTA 3O69A 4YPRA 5CFIA 5C7QA 3CNGA 3F13A 3I9XA 2AZWA 3I7VA 1PPXA 4KYXA 5GHJA 4ZG0A 3KVHA 5LPGA 3X0NA 4ICKA 1PPVA 3F6AA 1VK6A 3QSJA 2I8TA 2B0VA 4S2VA 1KHZA 2I6KA 4YPHA 2VNPA 2QJOA 3FSPA 2DUKA 3EF5A 2YYHA 1K2EA 1PUSA 2O5WA 2YVPA 1V8WA 2W4EA 5GHQA 1OW2A 3EXQA 5ANTA 3X0PA 2A8TA 1MR2A 5GHOA 3X0IA 3WHWA 5ISYA 3O8SA 1VIUA 2PQVA 4KG3A 5FSMA 3GRNA 3X0SA 1JKNA 1MK1A 1Q27A 2R5WA 3ID9A 3O6ZA 1NFZA 1XSCA 4C9XA 3GG6A 4JZUA 3X0JA 3SMDA 2A6TA 2DHOA 3G0QA 2JVBA 3MCFA 4KTBA 4V14A 1VC8A 1SOIA 2RRKA 1X84A 5C7TA 3DUPA 1V8VA 2KDWA 2YVNA 1V8MA 2O5FA 3L85A 3SHDA 5BONA 1I9AA 1V8RA 3Q1PA 4K6EA 4HFQA 1Q33A 1PUNA 1XSBA 2FVVA 3O61A 5FSLA 4S2YA 3GZ6A 1MQWA 4N1TA 2B2KA 5FSNA 2G73A 2YVOA 3AC9A 3X0KA 1GA7A 3I7UA 3X0QA 5ANSA 4J7HA 2CZRA 1X83A 3COUA 3X0RA 5IW5A 1PUQA 2J8QA 2Q9PA 3MDGA 5IW4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7G A;  4J7H A; 
#chains in the Genus database with same CATH topology
 3ZR1 A;  1NQZ A;  3DKU A;  5BS6 A;  3P6Y A;  2PNY A;  1PPW A;  1V8U A;  3X0O A;  1VRL A;  1TUM A;  4NFX A;  5C8L A;  1Q54 A;  3ZR0 A;  4DYW A;  3MGM A;  3A6U A;  1VCD A;  3BM4 A;  2VNQ A;  5GHP A;  3EEU A;  3N77 A;  4MPO A;  2YVM A;  1SU2 A;  1VC9 A;  2A8R A;  3FK9 A;  3Q2S A;  3Q91 A;  3J7Y e;  4HVY A;  2DSD A;  2GB5 A;  3BAP A;  3FJY A;  1V8I A;  1HZT A;  2FML A;  2G74 A;  2A8P A;  2ICJ A;  4KG4 A;  4IJX A;  1RRQ A;  1NQY A;  3BHO A;  1NFS A;  1VHZ A;  2I8U A;  2QKM B;  4J7G A;  4N1U A;  1U20 A;  1KTG A;  1SJY A;  5ANV A;  3R03 A;  3HHJ A;  2A8Q A;  1HX3 A;  1V8S A;  3MDI A;  2DSC A;  1SZ3 A;  2XSQ A;  3ACA A;  3Q2T A;  2KDV A;  1V8T A;  1X51 A;  4JZS A;  3HYQ A;  1G0S A;  3O52 A;  5DEQ A;  3Q93 A;  5DDG A;  3GZ5 A;  3X0L A;  1PVF A;  5DD4 A;  1RYA A;  3N9U A;  1G9Q A;  5ANU A;  1IRY A;  5HZX A;  1V8N A;  2A8S A;  2B06 A;  5GHI A;  4C9W A;  1MP2 A;  3A6S A;  4S2W A;  1RRS A;  5CFJ A;  3FCM A;  1V8Y A;  2ICK A;  2GT2 A;  3OGA A;  1JRK A;  1KT9 A;  4S2X A;  4JZV A;  3E57 A;  3SON A;  3A6V A;  1VIQ A;  2CL3 A;  1V8L A;  1VHG A;  4ILQ A;  5DPK A;  1MQE A;  3P5T A;  2FKB A;  3FFU A;  3X0M A;  4NFW A;  1F3Y A;  5I8U A;  3U53 A;  1K26 A;  3RH7 A;  5FSI A;  1R67 A;  1XSA A;  3A6T A;  3EES A;  5FSK A;  5FSO A;  1MUT A;  3Q4I A;  3H95 A;  5ANW A;  4YOQ A;  2O1C A;  3GZ8 A;  1QVJ A;  5GHN A;  5GHM A;  2QJT A;  2DSB A;  2GT4 A;  3GWY A;  4JZT A;  3O69 A;  4YPR A;  5CFI A;  5C7Q A;  3CNG A;  3F13 A;  3I9X A;  2AZW A;  3I7V A;  1PPX A;  4KYX A;  5GHJ A;  4ZG0 A;  3KVH A;  5LPG A;  3X0N A;  4ICK A;  1PPV A;  3F6A A;  1VK6 A;  3QSJ A;  2I8T A;  2B0V A;  4S2V A;  1KHZ A;  2I6K A;  4YPH A;  2VNP A;  2QJO A;  3FSP A;  2DUK A;  3EF5 A;  2YYH A;  1K2E A;  1PUS A;  2O5W A;  2YVP A;  1V8W A;  2W4E A;  5GHQ A;  1OW2 A;  3EXQ A;  5ANT A;  3X0P A;  2A8T A;  1MR2 A;  5GHO A;  3X0I A;  3WHW A;  5ISY A;  3O8S A;  1VIU A;  2PQV A;  4KG3 A;  5FSM A;  3GRN A;  3X0S A;  1JKN A;  1MK1 A;  1Q27 A;  2R5W A;  3ID9 A;  3O6Z A;  1NFZ A;  1XSC A;  4C9X A;  3GG6 A;  4JZU A;  3X0J A;  3SMD A;  2A6T A;  2DHO A;  3G0Q A;  2JVB A;  3MCF A;  4KTB A;  4V14 A;  1VC8 A;  1SOI A;  2RRK A;  1X84 A;  5C7T A;  3DUP A;  1V8V A;  2KDW A;  2YVN A;  1V8M A;  2O5F A;  3L85 A;  3SHD A;  5BON A;  1I9A A;  1V8R A;  3Q1P A;  4K6E A;  4HFQ A;  1Q33 A;  1PUN A;  1XSB A;  2FVV A;  3O61 A;  5FSL A;  4S2Y A;  3GZ6 A;  1MQW A;  4N1T A;  2B2K A;  5FSN A;  2G73 A;  2YVO A;  3AC9 A;  3X0K A;  1GA7 A;  3I7U A;  3X0Q A;  5ANS A;  4J7H A;  2CZR A;  1X83 A;  3COU A;  3X0R A;  5IW5 A;  1PUQ A;  2J8Q A;  2Q9P A;  3MDG A;  5IW4 A; 
#chains in the Genus database with same CATH homology
 3ZR1 A;  1NQZ A;  3DKU A;  5BS6 A;  3P6Y A;  2PNY A;  1PPW A;  1V8U A;  3X0O A;  1VRL A;  1TUM A;  4NFX A;  5C8L A;  1Q54 A;  3ZR0 A;  4DYW A;  3MGM A;  3A6U A;  1VCD A;  3BM4 A;  2VNQ A;  5GHP A;  3EEU A;  3N77 A;  4MPO A;  2YVM A;  1SU2 A;  1VC9 A;  2A8R A;  3FK9 A;  3Q2S A;  3Q91 A;  3J7Y e;  4HVY A;  2DSD A;  2GB5 A;  3BAP A;  3FJY A;  1V8I A;  1HZT A;  2FML A;  2G74 A;  2A8P A;  2ICJ A;  4KG4 A;  4IJX A;  1RRQ A;  1NQY A;  3BHO A;  1NFS A;  1VHZ A;  2I8U A;  2QKM B;  4J7G A;  4N1U A;  1U20 A;  1KTG A;  1SJY A;  5ANV A;  3R03 A;  3HHJ A;  2A8Q A;  1HX3 A;  1V8S A;  3MDI A;  2DSC A;  1SZ3 A;  2XSQ A;  3ACA A;  3Q2T A;  2KDV A;  1V8T A;  1X51 A;  4JZS A;  3HYQ A;  1G0S A;  3O52 A;  5DEQ A;  3Q93 A;  5DDG A;  3GZ5 A;  3X0L A;  1PVF A;  5DD4 A;  1RYA A;  3N9U A;  1G9Q A;  5ANU A;  1IRY A;  5HZX A;  1V8N A;  2A8S A;  2B06 A;  5GHI A;  4C9W A;  1MP2 A;  3A6S A;  4S2W A;  1RRS A;  5CFJ A;  3FCM A;  1V8Y A;  2ICK A;  2GT2 A;  3OGA A;  1JRK A;  1KT9 A;  4S2X A;  4JZV A;  3E57 A;  3SON A;  3A6V A;  1VIQ A;  2CL3 A;  1V8L A;  1VHG A;  4ILQ A;  5DPK A;  1MQE A;  3P5T A;  2FKB A;  3FFU A;  3X0M A;  4NFW A;  1F3Y A;  5I8U A;  3U53 A;  1K26 A;  3RH7 A;  5FSI A;  1R67 A;  1XSA A;  3A6T A;  3EES A;  5FSK A;  5FSO A;  1MUT A;  3Q4I A;  3H95 A;  5ANW A;  4YOQ A;  2O1C A;  3GZ8 A;  1QVJ A;  5GHN A;  5GHM A;  2QJT A;  2DSB A;  2GT4 A;  3GWY A;  4JZT A;  3O69 A;  4YPR A;  5CFI A;  5C7Q A;  3CNG A;  3F13 A;  3I9X A;  2AZW A;  3I7V A;  1PPX A;  4KYX A;  5GHJ A;  4ZG0 A;  3KVH A;  5LPG A;  3X0N A;  4ICK A;  1PPV A;  3F6A A;  1VK6 A;  3QSJ A;  2I8T A;  2B0V A;  4S2V A;  1KHZ A;  2I6K A;  4YPH A;  2VNP A;  2QJO A;  3FSP A;  2DUK A;  3EF5 A;  2YYH A;  1K2E A;  1PUS A;  2O5W A;  2YVP A;  1V8W A;  2W4E A;  5GHQ A;  1OW2 A;  3EXQ A;  5ANT A;  3X0P A;  2A8T A;  1MR2 A;  5GHO A;  3X0I A;  3WHW A;  5ISY A;  3O8S A;  1VIU A;  2PQV A;  4KG3 A;  5FSM A;  3GRN A;  3X0S A;  1JKN A;  1MK1 A;  1Q27 A;  2R5W A;  3ID9 A;  3O6Z A;  1NFZ A;  1XSC A;  4C9X A;  3GG6 A;  4JZU A;  3X0J A;  3SMD A;  2A6T A;  2DHO A;  3G0Q A;  2JVB A;  3MCF A;  4KTB A;  4V14 A;  1VC8 A;  1SOI A;  2RRK A;  1X84 A;  5C7T A;  3DUP A;  1V8V A;  2KDW A;  2YVN A;  1V8M A;  2O5F A;  3L85 A;  3SHD A;  5BON A;  1I9A A;  1V8R A;  3Q1P A;  4K6E A;  4HFQ A;  1Q33 A;  1PUN A;  1XSB A;  2FVV A;  3O61 A;  5FSL A;  4S2Y A;  3GZ6 A;  1MQW A;  4N1T A;  2B2K A;  5FSN A;  2G73 A;  2YVO A;  3AC9 A;  3X0K A;  1GA7 A;  3I7U A;  3X0Q A;  5ANS A;  4J7H A;  2CZR A;  1X83 A;  3COU A;  3X0R A;  5IW5 A;  1PUQ A;  2J8Q A;  2Q9P A;  3MDG A;  5IW4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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