2FXKA

Crystal structure of the macro-domain of human core histone variant macroh2a1.1 (form a)
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
187
structure length
187
Chain Sequence
GFTVLSTKSLFLGQKLQVVQADIASIDSDAVVHPTNTDFYIGGEVGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Splicing regulates NAD metabolite binding to histone macroH2A.
pubmed doi rcsb
molecule tags Gene regulation
source organism Homo sapiens
molecule keywords H2A histone family, member Y isoform 1
total genus 60
structure length 187
sequence length 187
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 2fxkA00
4J4ZA 1ZR5A 3IJ3A 1HJZA 1ZR3A 1YD9A 1LAMA 2BFRA 2X47A 1SPVA 4ZI6A 1BPNA 3V45A 4D86A 4ABKA 4IQYA 3VFQA 2L8RA 3KR4A 3JZTA 4GVWA 5HIHA 4ZX8A 3GPOA 5D8NA 2LGRA 4R6TA 1TY8A 4KYBA 4ZY1A 5FSVA 2DX6A 1LCPA 3SIHA 4ESSA 3KZWA 5FSUA 1BPMA 4X2TA 4ABLA 3KR5A 3EKEA 3EWQA 4JGKA 3GPQA 3SIJA 3EWOA 3V2BA 2AFCA 4JVVA 5AILA 4TU0A 3SIIA 5CB3A 5DUSA 4UMLA 3ETIA 4ZY0A 3GPGA 3JRUA 4J5QA 1GYTA 3Q6ZA 5FSZA 4K3NA 5CBMA 3GQOA 4ETJA 3KQZA 4KSIA 3H8EA 4J5SA 4ZY2A 1LANA 2FAVA 4JCAA 4JLLA 4ZX9A 1LAPA 2BFQA 2J9AA 5HOLA 1VHUA 2VRIA 3EJGA 5E3BA 4GVVA 4ETKA 4GUAA 3Q71A 3GQEA 3PEIA 3SIGA 1NJRA 5CMSA 3H8GA 1TXZA 4J5RA 2XD7A 5FSXA 3KQXA 2FG1A 3IIFA 5FSYA 2FXKA 3EWRA 4R7MA 4R76A 3IIDA 3T8WA 4ZYQA 2ACFA 2EWBA 4K0CA 2EEEA 3EW5A 5CB5A 3EJFA 3H8FA 3EWPA 1BLLE
chains in the Genus database with same CATH superfamily
2W2GA 4J4ZA 1ZR5A 3IJ3A 1HJZA 1ZR3A 1YD9A 1LAMA 2BFRA 2X47A 1SPVA 4ZI6A 1BPNA 3V45A 4D86A 4ABKA 4IQYA 3VFQA 2L8RA 3KR4A 3JZTA 4GVWA 5HIHA 4ZX8A 3GPOA 5D8NA 2LGRA 4R6TA 1TY8A 4KYBA 4ZY1A 5FSVA 2DX6A 2JZFA 1LCPA 3SIHA 4ESSA 3KZWA 5FSUA 1BPMA 4X2TA 4ABLA 3KR5A 3EKEA 3EWQA 4JGKA 3GPQA 3SIJA 3EWOA 3V2BA 2AFCA 4JVVA 5AILA 4TU0A 3SIIA 5CB3A 5DUSA 4UMLA 3ETIA 4ZY0A 3GPGA 3JRUA 4J5QA 1GYTA 2WCTA 3Q6ZA 5FSZA 2JZDA 4K3NA 5CBMA 3GQOA 4ETJA 3KQZA 4KSIA 3H8EA 4J5SA 4ZY2A 1LANA 2FAVA 4JCAA 4JLLA 4ZX9A 1LAPA 2BFQA 2J9AA 5HOLA 1VHUA 2VRIA 3EJGA 5E3BA 4GVVA 2KQVA 4ETKA 4GUAA 3Q71A 3GQEA 3PEIA 3SIGA 1NJRA 5CMSA 3H8GA 1TXZA 4J5RA 2XD7A 5FSXA 3KQXA 2FG1A 3IIFA 5FSYA 2FXKA 3EWRA 4R7MA 4R76A 3IIDA 3T8WA 4ZYQA 2ACFA 2EWBA 4K0CA 2EEEA 3EW5A 5CB5A 3EJFA 2RNKA 3H8FA 3EWPA 2JZEA 1BLLE
chains in the Genus database with same CATH topology
4J4ZA 1ZR5A 3IJ3A 1HJZA 1ZR3A 1YD9A 1LAMA 2BFRA 2X47A 1SPVA 4ZI6A 1BPNA 3V45A 4D86A 4ABKA 4IQYA 3VFQA 2L8RA 3KR4A 3JZTA 4GVWA 5HIHA 4ZX8A 3GPOA 5D8NA 2LGRA 4R6TA 1TY8A 4KYBA 4ZY1A 5FSVA 2DX6A 1LCPA 3SIHA 4ESSA 3KZWA 5FSUA 1BPMA 4X2TA 4ABLA 3KR5A 3EKEA 3EWQA 4JGKA 3GPQA 3SIJA 3EWOA 3V2BA 2AFCA 4JVVA 5AILA 4TU0A 3SIIA 5CB3A 5DUSA 4UMLA 3ETIA 4ZY0A 3GPGA 3JRUA 4J5QA 1GYTA 3Q6ZA 5FSZA 4K3NA 5CBMA 3GQOA 4ETJA 3KQZA 4KSIA 3H8EA 4J5SA 4ZY2A 1LANA 2FAVA 4JCAA 4JLLA 4ZX9A 1LAPA 2BFQA 2J9AA 5HOLA 1VHUA 2VRIA 3EJGA 5E3BA 4GVVA 4ETKA 4GUAA 3Q71A 3GQEA 3PEIA 3SIGA 1NJRA 5CMSA 3H8GA 1TXZA 4J5RA 2XD7A 5FSXA 3KQXA 2FG1A 3IIFA 5FSYA 2FXKA 3EWRA 4R7MA 4R76A 3IIDA 3T8WA 4ZYQA 2ACFA 2EWBA 4K0CA 2EEEA 3EW5A 5CB5A 3EJFA 3H8FA 3EWPA 1BLLE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J4Z A;  1ZR5 A;  3IJ3 A;  1HJZ A;  1ZR3 A;  1YD9 A;  1LAM A;  2BFR A;  2X47 A;  1SPV A;  4ZI6 A;  1BPN A;  3V45 A;  4D86 A;  4ABK A;  4IQY A;  3VFQ A;  2L8R A;  3KR4 A;  3JZT A;  4GVW A;  5HIH A;  4ZX8 A;  3GPO A;  5D8N A;  2LGR A;  4R6T A;  1TY8 A;  4KYB A;  4ZY1 A;  5FSV A;  2DX6 A;  1LCP A;  3SIH A;  4ESS A;  3KZW A;  5FSU A;  1BPM A;  4X2T A;  4ABL A;  3KR5 A;  3EKE A;  3EWQ A;  4JGK A;  3GPQ A;  3SIJ A;  3EWO A;  3V2B A;  2AFC A;  4JVV A;  5AIL A;  4TU0 A;  3SII A;  5CB3 A;  5DUS A;  4UML A;  3ETI A;  4ZY0 A;  3GPG A;  3JRU A;  4J5Q A;  1GYT A;  3Q6Z A;  5FSZ A;  4K3N A;  5CBM A;  3GQO A;  4ETJ A;  3KQZ A;  4KSI A;  3H8E A;  4J5S A;  4ZY2 A;  1LAN A;  2FAV A;  4JCA A;  4JLL A;  4ZX9 A;  1LAP A;  2BFQ A;  2J9A A;  5HOL A;  1VHU A;  2VRI A;  3EJG A;  5E3B A;  4GVV A;  4ETK A;  4GUA A;  3Q71 A;  3GQE A;  3PEI A;  3SIG A;  1NJR A;  5CMS A;  3H8G A;  1TXZ A;  4J5R A;  2XD7 A;  5FSX A;  3KQX A;  2FG1 A;  3IIF A;  5FSY A;  2FXK A;  3EWR A;  4R7M A;  4R76 A;  3IID A;  3T8W A;  4ZYQ A;  2ACF A;  2EWB A;  4K0C A;  2EEE A;  3EW5 A;  5CB5 A;  3EJF A;  3H8F A;  3EWP A;  1BLL E; 
#chains in the Genus database with same CATH topology
 2W2G A;  4J4Z A;  1ZR5 A;  3IJ3 A;  1HJZ A;  1ZR3 A;  1YD9 A;  1LAM A;  2BFR A;  2X47 A;  1SPV A;  4ZI6 A;  1BPN A;  3V45 A;  4D86 A;  4ABK A;  4IQY A;  3VFQ A;  2L8R A;  3KR4 A;  3JZT A;  4GVW A;  5HIH A;  4ZX8 A;  3GPO A;  5D8N A;  2LGR A;  4R6T A;  1TY8 A;  4KYB A;  4ZY1 A;  5FSV A;  2DX6 A;  2JZF A;  1LCP A;  3SIH A;  4ESS A;  3KZW A;  5FSU A;  1BPM A;  4X2T A;  4ABL A;  3KR5 A;  3EKE A;  3EWQ A;  4JGK A;  3GPQ A;  3SIJ A;  3EWO A;  3V2B A;  2AFC A;  4JVV A;  5AIL A;  4TU0 A;  3SII A;  5CB3 A;  5DUS A;  4UML A;  3ETI A;  4ZY0 A;  3GPG A;  3JRU A;  4J5Q A;  1GYT A;  2WCT A;  3Q6Z A;  5FSZ A;  2JZD A;  4K3N A;  5CBM A;  3GQO A;  4ETJ A;  3KQZ A;  4KSI A;  3H8E A;  4J5S A;  4ZY2 A;  1LAN A;  2FAV A;  4JCA A;  4JLL A;  4ZX9 A;  1LAP A;  2BFQ A;  2J9A A;  5HOL A;  1VHU A;  2VRI A;  3EJG A;  5E3B A;  4GVV A;  2KQV A;  4ETK A;  4GUA A;  3Q71 A;  3GQE A;  3PEI A;  3SIG A;  1NJR A;  5CMS A;  3H8G A;  1TXZ A;  4J5R A;  2XD7 A;  5FSX A;  3KQX A;  2FG1 A;  3IIF A;  5FSY A;  2FXK A;  3EWR A;  4R7M A;  4R76 A;  3IID A;  3T8W A;  4ZYQ A;  2ACF A;  2EWB A;  4K0C A;  2EEE A;  3EW5 A;  5CB5 A;  3EJF A;  2RNK A;  3H8F A;  3EWP A;  2JZE A;  1BLL E; 
#chains in the Genus database with same CATH homology
 4J4Z A;  1ZR5 A;  3IJ3 A;  1HJZ A;  1ZR3 A;  1YD9 A;  1LAM A;  2BFR A;  2X47 A;  1SPV A;  4ZI6 A;  1BPN A;  3V45 A;  4D86 A;  4ABK A;  4IQY A;  3VFQ A;  2L8R A;  3KR4 A;  3JZT A;  4GVW A;  5HIH A;  4ZX8 A;  3GPO A;  5D8N A;  2LGR A;  4R6T A;  1TY8 A;  4KYB A;  4ZY1 A;  5FSV A;  2DX6 A;  1LCP A;  3SIH A;  4ESS A;  3KZW A;  5FSU A;  1BPM A;  4X2T A;  4ABL A;  3KR5 A;  3EKE A;  3EWQ A;  4JGK A;  3GPQ A;  3SIJ A;  3EWO A;  3V2B A;  2AFC A;  4JVV A;  5AIL A;  4TU0 A;  3SII A;  5CB3 A;  5DUS A;  4UML A;  3ETI A;  4ZY0 A;  3GPG A;  3JRU A;  4J5Q A;  1GYT A;  3Q6Z A;  5FSZ A;  4K3N A;  5CBM A;  3GQO A;  4ETJ A;  3KQZ A;  4KSI A;  3H8E A;  4J5S A;  4ZY2 A;  1LAN A;  2FAV A;  4JCA A;  4JLL A;  4ZX9 A;  1LAP A;  2BFQ A;  2J9A A;  5HOL A;  1VHU A;  2VRI A;  3EJG A;  5E3B A;  4GVV A;  4ETK A;  4GUA A;  3Q71 A;  3GQE A;  3PEI A;  3SIG A;  1NJR A;  5CMS A;  3H8G A;  1TXZ A;  4J5R A;  2XD7 A;  5FSX A;  3KQX A;  2FG1 A;  3IIF A;  5FSY A;  2FXK A;  3EWR A;  4R7M A;  4R76 A;  3IID A;  3T8W A;  4ZYQ A;  2ACF A;  2EWB A;  4K0C A;  2EEE A;  3EW5 A;  5CB5 A;  3EJF A;  3H8F A;  3EWP A;  1BLL E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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