2FXKA

Crystal structure of the macro-domain of human core histone variant macroh2a1.1 (form a)
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
187
structure length
187
Chain Sequence
GFTVLSTKSLFLGQKLQVVQADIASIDSDAVVHPTNTDFYIGGEVGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Splicing regulates NAD metabolite binding to histone macroH2A.
pubmed doi rcsb
molecule tags Gene regulation
source organism Homo sapiens
molecule keywords H2A histone family, member Y isoform 1
total genus 60
structure length 187
sequence length 187
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 2fxkA00
5FSXA 1LCPA 3SIIA 4R76A 4ZYQA 1LAPA 4KSIA 4JCAA 4J5SA 4ZI6A 4ZX8A 1LAMA 1YD9A 4K3NA 4ZY2A 1LANA 3H8FA 4ABKA 5CBMA 3SIHA 3EWOA 1VHUA 4ZX9A 4JVVA 3GPGA 2BFRA 2X47A 1BPMA 2EEEA 5DUSA 3JZTA 3PEIA 3IJ3A 5FSYA 5CB3A 5CB5A 4J5RA 5HIHA 4D86A 1ZR5A 3KR5A 1GYTA 5FSZA 3JRUA 3SIJA 4IQYA 4J4ZA 3GPOA 2LGRA 1SPVA 2VRIA 3GPQA 5HOLA 4UMLA 5FSUA 4GUAA 4GVVA 3ETIA 2BFQA 3KQXA 3H8GA 3EW5A 3H8EA 3IIFA 4ESSA 2L8RA 4GVWA 4ZY1A 4K0CA 5CMSA 4R7MA 1TXZA 3EWQA 3T8WA 4JGKA 4JLLA 3V2BA 4J5QA 2FG1A 4TU0A 3GQOA 3KQZA 3IIDA 1ZR3A 1HJZA 2DX6A 2XD7A 4X2TA 2FXKA 3Q71A 4R6TA 3EWPA 2J9AA 3VFQA 5E3BA 3KR4A 2FAVA 2ACFA 5AILA 5FSVA 3KZWA 3V45A 4ZY0A 3EKEA 1TY8A 1BLLE 4ETJA 2AFCA 1NJRA 4KYBA 3EJGA 5D8NA 3EWRA 3GQEA 1BPNA 2EWBA 4ABLA 3Q6ZA 3EJFA 3SIGA 4ETKA
chains in the Genus database with same CATH superfamily
5FSXA 1LCPA 3SIIA 4R76A 4ZYQA 1LAPA 4KSIA 4JCAA 4J5SA 4ZI6A 4ZX8A 1LAMA 1YD9A 4K3NA 4ZY2A 1LANA 2JZEA 3H8FA 4ABKA 5CBMA 3SIHA 3EWOA 1VHUA 4ZX9A 2W2GA 4JVVA 3GPGA 2BFRA 2X47A 1BPMA 2EEEA 5DUSA 3JZTA 3PEIA 3IJ3A 5FSYA 5CB3A 5CB5A 4J5RA 5HIHA 4D86A 1ZR5A 3KR5A 1GYTA 5FSZA 3JRUA 3SIJA 4IQYA 4J4ZA 3GPOA 2LGRA 1SPVA 2RNKA 2VRIA 3GPQA 5HOLA 4UMLA 5FSUA 4GUAA 4GVVA 3ETIA 2BFQA 3KQXA 3H8GA 3EW5A 3H8EA 2JZFA 3IIFA 2WCTA 4ESSA 2L8RA 4GVWA 4ZY1A 4K0CA 2JZDA 5CMSA 4R7MA 1TXZA 3EWQA 3T8WA 4JGKA 4JLLA 3V2BA 4J5QA 2FG1A 4TU0A 3GQOA 3KQZA 3IIDA 1ZR3A 1HJZA 2DX6A 2XD7A 4X2TA 2FXKA 3Q71A 4R6TA 3EWPA 2J9AA 3VFQA 5E3BA 3KR4A 2FAVA 2ACFA 5AILA 5FSVA 3KZWA 3V45A 4ZY0A 3EKEA 1TY8A 1BLLE 4ETJA 2AFCA 1NJRA 4KYBA 3EJGA 5D8NA 3EWRA 3GQEA 2KQVA 1BPNA 2EWBA 4ABLA 3Q6ZA 3EJFA 3SIGA 4ETKA
chains in the Genus database with same CATH topology
5FSXA 1LCPA 3SIIA 4R76A 4ZYQA 1LAPA 4KSIA 4JCAA 4J5SA 4ZI6A 4ZX8A 1LAMA 1YD9A 4K3NA 4ZY2A 1LANA 3H8FA 4ABKA 5CBMA 3SIHA 3EWOA 1VHUA 4ZX9A 4JVVA 3GPGA 2BFRA 2X47A 1BPMA 2EEEA 5DUSA 3JZTA 3PEIA 3IJ3A 5FSYA 5CB3A 5CB5A 4J5RA 5HIHA 4D86A 1ZR5A 3KR5A 1GYTA 5FSZA 3JRUA 3SIJA 4IQYA 4J4ZA 3GPOA 2LGRA 1SPVA 2VRIA 3GPQA 5HOLA 4UMLA 5FSUA 4GUAA 4GVVA 3ETIA 2BFQA 3KQXA 3H8GA 3EW5A 3H8EA 3IIFA 4ESSA 2L8RA 4GVWA 4ZY1A 4K0CA 5CMSA 4R7MA 1TXZA 3EWQA 3T8WA 4JGKA 4JLLA 3V2BA 4J5QA 2FG1A 4TU0A 3GQOA 3KQZA 3IIDA 1ZR3A 1HJZA 2DX6A 2XD7A 4X2TA 2FXKA 3Q71A 4R6TA 3EWPA 2J9AA 3VFQA 5E3BA 3KR4A 2FAVA 2ACFA 5AILA 5FSVA 3KZWA 3V45A 4ZY0A 3EKEA 1TY8A 1BLLE 4ETJA 2AFCA 1NJRA 4KYBA 3EJGA 5D8NA 3EWRA 3GQEA 1BPNA 2EWBA 4ABLA 3Q6ZA 3EJFA 3SIGA 4ETKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FSX A;  1LCP A;  3SII A;  4R76 A;  4ZYQ A;  1LAP A;  4KSI A;  4JCA A;  4J5S A;  4ZI6 A;  4ZX8 A;  1LAM A;  1YD9 A;  4K3N A;  4ZY2 A;  1LAN A;  3H8F A;  4ABK A;  5CBM A;  3SIH A;  3EWO A;  1VHU A;  4ZX9 A;  4JVV A;  3GPG A;  2BFR A;  2X47 A;  1BPM A;  2EEE A;  5DUS A;  3JZT A;  3PEI A;  3IJ3 A;  5FSY A;  5CB3 A;  5CB5 A;  4J5R A;  5HIH A;  4D86 A;  1ZR5 A;  3KR5 A;  1GYT A;  5FSZ A;  3JRU A;  3SIJ A;  4IQY A;  4J4Z A;  3GPO A;  2LGR A;  1SPV A;  2VRI A;  3GPQ A;  5HOL A;  4UML A;  5FSU A;  4GUA A;  4GVV A;  3ETI A;  2BFQ A;  3KQX A;  3H8G A;  3EW5 A;  3H8E A;  3IIF A;  4ESS A;  2L8R A;  4GVW A;  4ZY1 A;  4K0C A;  5CMS A;  4R7M A;  1TXZ A;  3EWQ A;  3T8W A;  4JGK A;  4JLL A;  3V2B A;  4J5Q A;  2FG1 A;  4TU0 A;  3GQO A;  3KQZ A;  3IID A;  1ZR3 A;  1HJZ A;  2DX6 A;  2XD7 A;  4X2T A;  2FXK A;  3Q71 A;  4R6T A;  3EWP A;  2J9A A;  3VFQ A;  5E3B A;  3KR4 A;  2FAV A;  2ACF A;  5AIL A;  5FSV A;  3KZW A;  3V45 A;  4ZY0 A;  3EKE A;  1TY8 A;  1BLL E;  4ETJ A;  2AFC A;  1NJR A;  4KYB A;  3EJG A;  5D8N A;  3EWR A;  3GQE A;  1BPN A;  2EWB A;  4ABL A;  3Q6Z A;  3EJF A;  3SIG A;  4ETK A; 
#chains in the Genus database with same CATH topology
 5FSX A;  1LCP A;  3SII A;  4R76 A;  4ZYQ A;  1LAP A;  4KSI A;  4JCA A;  4J5S A;  4ZI6 A;  4ZX8 A;  1LAM A;  1YD9 A;  4K3N A;  4ZY2 A;  1LAN A;  2JZE A;  3H8F A;  4ABK A;  5CBM A;  3SIH A;  3EWO A;  1VHU A;  4ZX9 A;  2W2G A;  4JVV A;  3GPG A;  2BFR A;  2X47 A;  1BPM A;  2EEE A;  5DUS A;  3JZT A;  3PEI A;  3IJ3 A;  5FSY A;  5CB3 A;  5CB5 A;  4J5R A;  5HIH A;  4D86 A;  1ZR5 A;  3KR5 A;  1GYT A;  5FSZ A;  3JRU A;  3SIJ A;  4IQY A;  4J4Z A;  3GPO A;  2LGR A;  1SPV A;  2RNK A;  2VRI A;  3GPQ A;  5HOL A;  4UML A;  5FSU A;  4GUA A;  4GVV A;  3ETI A;  2BFQ A;  3KQX A;  3H8G A;  3EW5 A;  3H8E A;  2JZF A;  3IIF A;  2WCT A;  4ESS A;  2L8R A;  4GVW A;  4ZY1 A;  4K0C A;  2JZD A;  5CMS A;  4R7M A;  1TXZ A;  3EWQ A;  3T8W A;  4JGK A;  4JLL A;  3V2B A;  4J5Q A;  2FG1 A;  4TU0 A;  3GQO A;  3KQZ A;  3IID A;  1ZR3 A;  1HJZ A;  2DX6 A;  2XD7 A;  4X2T A;  2FXK A;  3Q71 A;  4R6T A;  3EWP A;  2J9A A;  3VFQ A;  5E3B A;  3KR4 A;  2FAV A;  2ACF A;  5AIL A;  5FSV A;  3KZW A;  3V45 A;  4ZY0 A;  3EKE A;  1TY8 A;  1BLL E;  4ETJ A;  2AFC A;  1NJR A;  4KYB A;  3EJG A;  5D8N A;  3EWR A;  3GQE A;  2KQV A;  1BPN A;  2EWB A;  4ABL A;  3Q6Z A;  3EJF A;  3SIG A;  4ETK A; 
#chains in the Genus database with same CATH homology
 5FSX A;  1LCP A;  3SII A;  4R76 A;  4ZYQ A;  1LAP A;  4KSI A;  4JCA A;  4J5S A;  4ZI6 A;  4ZX8 A;  1LAM A;  1YD9 A;  4K3N A;  4ZY2 A;  1LAN A;  3H8F A;  4ABK A;  5CBM A;  3SIH A;  3EWO A;  1VHU A;  4ZX9 A;  4JVV A;  3GPG A;  2BFR A;  2X47 A;  1BPM A;  2EEE A;  5DUS A;  3JZT A;  3PEI A;  3IJ3 A;  5FSY A;  5CB3 A;  5CB5 A;  4J5R A;  5HIH A;  4D86 A;  1ZR5 A;  3KR5 A;  1GYT A;  5FSZ A;  3JRU A;  3SIJ A;  4IQY A;  4J4Z A;  3GPO A;  2LGR A;  1SPV A;  2VRI A;  3GPQ A;  5HOL A;  4UML A;  5FSU A;  4GUA A;  4GVV A;  3ETI A;  2BFQ A;  3KQX A;  3H8G A;  3EW5 A;  3H8E A;  3IIF A;  4ESS A;  2L8R A;  4GVW A;  4ZY1 A;  4K0C A;  5CMS A;  4R7M A;  1TXZ A;  3EWQ A;  3T8W A;  4JGK A;  4JLL A;  3V2B A;  4J5Q A;  2FG1 A;  4TU0 A;  3GQO A;  3KQZ A;  3IID A;  1ZR3 A;  1HJZ A;  2DX6 A;  2XD7 A;  4X2T A;  2FXK A;  3Q71 A;  4R6T A;  3EWP A;  2J9A A;  3VFQ A;  5E3B A;  3KR4 A;  2FAV A;  2ACF A;  5AIL A;  5FSV A;  3KZW A;  3V45 A;  4ZY0 A;  3EKE A;  1TY8 A;  1BLL E;  4ETJ A;  2AFC A;  1NJR A;  4KYB A;  3EJG A;  5D8N A;  3EWR A;  3GQE A;  1BPN A;  2EWB A;  4ABL A;  3Q6Z A;  3EJF A;  3SIG A;  4ETK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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