5HIHA

Crystal structure of the macro domain in middle-east respiratory syndrome coronavirus
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
167
structure length
167
Chain Sequence
MDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
pubmed doi rcsb
source organism Middle east respiratory syndrome coronavirus
molecule tags Viral protein
molecule keywords ORF1a
total genus 57
structure length 167
sequence length 167
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2016-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5hihA00
2XD7A 1LANA 1BPNA 3ETIA 4UMLA 3IIDA 3GPOA 4ZY2A 5FSVA 3SIHA 4JVVA 3EWPA 5HIHA 3H8GA 1BLLE 4ZYQA 3IJ3A 3EJGA 1LCPA 3H8EA 5CMSA 2L8RA 4GUAA 5CBMA 4KSIA 3EJFA 3EWOA 4D86A 2EWBA 4ABKA 5D8NA 3JZTA 2FG1A 4J4ZA 3EWQA 2LGRA 3SIJA 1YD9A 4K3NA 5E3BA 4ETJA 4ZY1A 5FSZA 3V2BA 4R7MA 1GYTA 5FSYA 4R6TA 1LAMA 4ZX9A 4K0CA 3GQEA 1ZR5A 4ZI6A 4ZX8A 2BFRA 2VRIA 1LAPA 2FXKA 4JGKA 4TU0A 3GPGA 4R76A 3GQOA 3JRUA 1NJRA 3SIIA 3EWRA 1SPVA 5HOLA 3KZWA 3KQZA 5FSXA 5FSUA 1TXZA 2AFCA 4JCAA 3T8WA 3Q71A 3H8FA 3VFQA 3KQXA 4KYBA 3IIFA 1VHUA 5AILA 2EEEA 3KR4A 1HJZA 3SIGA 2ACFA 5CB3A 3KR5A 1ZR3A 3Q6ZA 4ABLA 2BFQA 3PEIA 4J5QA 5DUSA 1BPMA 5CB5A 4JLLA 3EW5A 4ESSA 3V45A 3GPQA 2X47A 4ZY0A 2J9AA 4J5SA 4GVVA 4IQYA 4X2TA 4GVWA 4J5RA 4ETKA 2FAVA 1TY8A 3EKEA 2DX6A
chains in the Genus database with same CATH superfamily
2XD7A 1LANA 1BPNA 3ETIA 4UMLA 3IIDA 3GPOA 4ZY2A 5FSVA 3SIHA 4JVVA 3EWPA 5HIHA 3H8GA 2WCTA 1BLLE 4ZYQA 3IJ3A 3EJGA 1LCPA 3H8EA 5CMSA 2L8RA 4GUAA 5CBMA 4KSIA 3EJFA 3EWOA 4D86A 2EWBA 4ABKA 5D8NA 3JZTA 2FG1A 4J4ZA 3EWQA 2LGRA 3SIJA 1YD9A 4K3NA 5E3BA 4ETJA 4ZY1A 5FSZA 3V2BA 4R7MA 1GYTA 5FSYA 4R6TA 1LAMA 2RNKA 4ZX9A 4K0CA 3GQEA 1ZR5A 4ZI6A 4ZX8A 2BFRA 2VRIA 1LAPA 2FXKA 2JZDA 4JGKA 4TU0A 3GPGA 4R76A 2KQVA 3GQOA 3JRUA 1NJRA 3SIIA 3EWRA 1SPVA 5HOLA 3KZWA 3KQZA 5FSXA 2JZEA 5FSUA 1TXZA 2AFCA 4JCAA 3T8WA 3Q71A 3H8FA 3VFQA 4KYBA 3KQXA 3IIFA 1VHUA 2JZFA 5AILA 2EEEA 3KR4A 1HJZA 3SIGA 2ACFA 5CB3A 3KR5A 1ZR3A 3Q6ZA 4ABLA 2BFQA 3PEIA 4J5QA 5DUSA 1BPMA 5CB5A 4JLLA 3EW5A 4ESSA 3V45A 3GPQA 2X47A 4ZY0A 2J9AA 4J5SA 2W2GA 4GVVA 4IQYA 4X2TA 4GVWA 4J5RA 4ETKA 2FAVA 1TY8A 3EKEA 2DX6A
chains in the Genus database with same CATH topology
2XD7A 1LANA 1BPNA 3ETIA 4UMLA 3IIDA 3GPOA 4ZY2A 5FSVA 3SIHA 4JVVA 3EWPA 5HIHA 3H8GA 1BLLE 4ZYQA 3IJ3A 3EJGA 1LCPA 3H8EA 5CMSA 2L8RA 4GUAA 5CBMA 4KSIA 3EJFA 3EWOA 4D86A 2EWBA 4ABKA 5D8NA 3JZTA 2FG1A 4J4ZA 3EWQA 2LGRA 3SIJA 1YD9A 4K3NA 5E3BA 4ETJA 4ZY1A 5FSZA 3V2BA 4R7MA 1GYTA 5FSYA 4R6TA 1LAMA 4ZX9A 4K0CA 3GQEA 1ZR5A 4ZI6A 4ZX8A 2BFRA 2VRIA 1LAPA 2FXKA 4JGKA 4TU0A 3GPGA 4R76A 3GQOA 3JRUA 1NJRA 3SIIA 3EWRA 1SPVA 5HOLA 3KZWA 3KQZA 5FSXA 5FSUA 1TXZA 2AFCA 4JCAA 3T8WA 3Q71A 3H8FA 3VFQA 3KQXA 4KYBA 3IIFA 1VHUA 5AILA 2EEEA 3KR4A 1HJZA 3SIGA 2ACFA 5CB3A 3KR5A 1ZR3A 3Q6ZA 4ABLA 2BFQA 3PEIA 4J5QA 5DUSA 1BPMA 5CB5A 4JLLA 3EW5A 4ESSA 3V45A 3GPQA 2X47A 4ZY0A 2J9AA 4J5SA 4GVVA 4IQYA 4X2TA 4GVWA 4J5RA 4ETKA 2FAVA 1TY8A 3EKEA 2DX6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XD7 A;  1LAN A;  1BPN A;  3ETI A;  4UML A;  3IID A;  3GPO A;  4ZY2 A;  5FSV A;  3SIH A;  4JVV A;  3EWP A;  5HIH A;  3H8G A;  1BLL E;  4ZYQ A;  3IJ3 A;  3EJG A;  1LCP A;  3H8E A;  5CMS A;  2L8R A;  4GUA A;  5CBM A;  4KSI A;  3EJF A;  3EWO A;  4D86 A;  2EWB A;  4ABK A;  5D8N A;  3JZT A;  2FG1 A;  4J4Z A;  3EWQ A;  2LGR A;  3SIJ A;  1YD9 A;  4K3N A;  5E3B A;  4ETJ A;  4ZY1 A;  5FSZ A;  3V2B A;  4R7M A;  1GYT A;  5FSY A;  4R6T A;  1LAM A;  4ZX9 A;  4K0C A;  3GQE A;  1ZR5 A;  4ZI6 A;  4ZX8 A;  2BFR A;  2VRI A;  1LAP A;  2FXK A;  4JGK A;  4TU0 A;  3GPG A;  4R76 A;  3GQO A;  3JRU A;  1NJR A;  3SII A;  3EWR A;  1SPV A;  5HOL A;  3KZW A;  3KQZ A;  5FSX A;  5FSU A;  1TXZ A;  2AFC A;  4JCA A;  3T8W A;  3Q71 A;  3H8F A;  3VFQ A;  3KQX A;  4KYB A;  3IIF A;  1VHU A;  5AIL A;  2EEE A;  3KR4 A;  1HJZ A;  3SIG A;  2ACF A;  5CB3 A;  3KR5 A;  1ZR3 A;  3Q6Z A;  4ABL A;  2BFQ A;  3PEI A;  4J5Q A;  5DUS A;  1BPM A;  5CB5 A;  4JLL A;  3EW5 A;  4ESS A;  3V45 A;  3GPQ A;  2X47 A;  4ZY0 A;  2J9A A;  4J5S A;  4GVV A;  4IQY A;  4X2T A;  4GVW A;  4J5R A;  4ETK A;  2FAV A;  1TY8 A;  3EKE A;  2DX6 A; 
#chains in the Genus database with same CATH topology
 2XD7 A;  1LAN A;  1BPN A;  3ETI A;  4UML A;  3IID A;  3GPO A;  4ZY2 A;  5FSV A;  3SIH A;  4JVV A;  3EWP A;  5HIH A;  3H8G A;  2WCT A;  1BLL E;  4ZYQ A;  3IJ3 A;  3EJG A;  1LCP A;  3H8E A;  5CMS A;  2L8R A;  4GUA A;  5CBM A;  4KSI A;  3EJF A;  3EWO A;  4D86 A;  2EWB A;  4ABK A;  5D8N A;  3JZT A;  2FG1 A;  4J4Z A;  3EWQ A;  2LGR A;  3SIJ A;  1YD9 A;  4K3N A;  5E3B A;  4ETJ A;  4ZY1 A;  5FSZ A;  3V2B A;  4R7M A;  1GYT A;  5FSY A;  4R6T A;  1LAM A;  2RNK A;  4ZX9 A;  4K0C A;  3GQE A;  1ZR5 A;  4ZI6 A;  4ZX8 A;  2BFR A;  2VRI A;  1LAP A;  2FXK A;  2JZD A;  4JGK A;  4TU0 A;  3GPG A;  4R76 A;  2KQV A;  3GQO A;  3JRU A;  1NJR A;  3SII A;  3EWR A;  1SPV A;  5HOL A;  3KZW A;  3KQZ A;  5FSX A;  2JZE A;  5FSU A;  1TXZ A;  2AFC A;  4JCA A;  3T8W A;  3Q71 A;  3H8F A;  3VFQ A;  4KYB A;  3KQX A;  3IIF A;  1VHU A;  2JZF A;  5AIL A;  2EEE A;  3KR4 A;  1HJZ A;  3SIG A;  2ACF A;  5CB3 A;  3KR5 A;  1ZR3 A;  3Q6Z A;  4ABL A;  2BFQ A;  3PEI A;  4J5Q A;  5DUS A;  1BPM A;  5CB5 A;  4JLL A;  3EW5 A;  4ESS A;  3V45 A;  3GPQ A;  2X47 A;  4ZY0 A;  2J9A A;  4J5S A;  2W2G A;  4GVV A;  4IQY A;  4X2T A;  4GVW A;  4J5R A;  4ETK A;  2FAV A;  1TY8 A;  3EKE A;  2DX6 A; 
#chains in the Genus database with same CATH homology
 2XD7 A;  1LAN A;  1BPN A;  3ETI A;  4UML A;  3IID A;  3GPO A;  4ZY2 A;  5FSV A;  3SIH A;  4JVV A;  3EWP A;  5HIH A;  3H8G A;  1BLL E;  4ZYQ A;  3IJ3 A;  3EJG A;  1LCP A;  3H8E A;  5CMS A;  2L8R A;  4GUA A;  5CBM A;  4KSI A;  3EJF A;  3EWO A;  4D86 A;  2EWB A;  4ABK A;  5D8N A;  3JZT A;  2FG1 A;  4J4Z A;  3EWQ A;  2LGR A;  3SIJ A;  1YD9 A;  4K3N A;  5E3B A;  4ETJ A;  4ZY1 A;  5FSZ A;  3V2B A;  4R7M A;  1GYT A;  5FSY A;  4R6T A;  1LAM A;  4ZX9 A;  4K0C A;  3GQE A;  1ZR5 A;  4ZI6 A;  4ZX8 A;  2BFR A;  2VRI A;  1LAP A;  2FXK A;  4JGK A;  4TU0 A;  3GPG A;  4R76 A;  3GQO A;  3JRU A;  1NJR A;  3SII A;  3EWR A;  1SPV A;  5HOL A;  3KZW A;  3KQZ A;  5FSX A;  5FSU A;  1TXZ A;  2AFC A;  4JCA A;  3T8W A;  3Q71 A;  3H8F A;  3VFQ A;  3KQX A;  4KYB A;  3IIF A;  1VHU A;  5AIL A;  2EEE A;  3KR4 A;  1HJZ A;  3SIG A;  2ACF A;  5CB3 A;  3KR5 A;  1ZR3 A;  3Q6Z A;  4ABL A;  2BFQ A;  3PEI A;  4J5Q A;  5DUS A;  1BPM A;  5CB5 A;  4JLL A;  3EW5 A;  4ESS A;  3V45 A;  3GPQ A;  2X47 A;  4ZY0 A;  2J9A A;  4J5S A;  4GVV A;  4IQY A;  4X2T A;  4GVW A;  4J5R A;  4ETK A;  2FAV A;  1TY8 A;  3EKE A;  2DX6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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