5HIHA

Crystal structure of the macro domain in middle-east respiratory syndrome coronavirus
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
167
structure length
167
Chain Sequence
MDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
pubmed doi rcsb
molecule keywords ORF1a
molecule tags Viral protein
source organism Middle east respiratory syndrome coronavirus
total genus 57
structure length 167
sequence length 167
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2016-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5hihA00
4J5RA 2DX6A 4JGKA 1BLLE 2BFQA 4J5QA 3EKEA 3EWPA 1ZR5A 3JZTA 3GPOA 5CB3A 4ETKA 3SIGA 2XD7A 3EWQA 3H8EA 3Q6ZA 3EW5A 4D86A 4GVWA 5DUSA 4K0CA 2J9AA 3GQEA 3Q71A 4JVVA 3KQXA 2EWBA 3VFQA 4KSIA 1GYTA 4K3NA 4ESSA 3KR5A 4ZY2A 2FXKA 2AFCA 4GUAA 1YD9A 4J5SA 5E3BA 4ZX9A 5FSZA 3IJ3A 3V45A 3V2BA 3EJGA 4ETJA 4ZI6A 1SPVA 3IIFA 3JRUA 2X47A 1NJRA 4ABLA 2BFRA 3H8GA 4IQYA 4JCAA 4UMLA 5FSVA 1VHUA 4R7MA 1LAPA 5CMSA 4ZY0A 5AILA 1LANA 2VRIA 4X2TA 2L8RA 3GPGA 3EWRA 3PEIA 3EJFA 4ZYQA 3KR4A 2FAVA 3H8FA 4GVVA 3SIIA 1BPMA 2FG1A 2EEEA 4J4ZA 1ZR3A 3GQOA 3KZWA 5CBMA 5FSYA 3EWOA 5FSUA 4ZY1A 5FSXA 4ABKA 3SIHA 3ETIA 1LCPA 3KQZA 4JLLA 3IIDA 5D8NA 4ZX8A 5HOLA 1TXZA 4TU0A 1HJZA 4KYBA 2LGRA 4R6TA 4R76A 3T8WA 1LAMA 5CB5A 3SIJA 1BPNA 5HIHA 2ACFA 3GPQA 1TY8A
chains in the Genus database with same CATH superfamily
4J5RA 2DX6A 2JZEA 4JGKA 1BLLE 2BFQA 4J5QA 3EKEA 2KQVA 3EWPA 2WCTA 1ZR5A 3JZTA 3GPOA 5CB3A 4ETKA 3SIGA 2XD7A 2JZDA 3EWQA 3H8EA 3Q6ZA 3EW5A 4D86A 4GVWA 5DUSA 4K0CA 2J9AA 3GQEA 3Q71A 4JVVA 3KQXA 2EWBA 3VFQA 4KSIA 1GYTA 4K3NA 4ESSA 3KR5A 4ZY2A 2FXKA 2AFCA 4GUAA 1YD9A 4J5SA 5E3BA 4ZX9A 5FSZA 3IJ3A 3V45A 3V2BA 2RNKA 3EJGA 4ETJA 4ZI6A 1SPVA 3IIFA 3JRUA 2X47A 1NJRA 4ABLA 2BFRA 3H8GA 4IQYA 4JCAA 4UMLA 5FSVA 1VHUA 4R7MA 1LAPA 5CMSA 4ZY0A 5AILA 1LANA 2VRIA 4X2TA 2L8RA 3GPGA 3EWRA 3PEIA 3EJFA 4ZYQA 3KR4A 2FAVA 3H8FA 4GVVA 3SIIA 2W2GA 1BPMA 2FG1A 2EEEA 4J4ZA 1ZR3A 3GQOA 3KZWA 5CBMA 5FSYA 3EWOA 5FSUA 4ZY1A 5FSXA 4ABKA 3SIHA 3ETIA 1LCPA 3KQZA 4JLLA 3IIDA 5D8NA 4ZX8A 5HOLA 1TXZA 4TU0A 1HJZA 4KYBA 2JZFA 2LGRA 4R6TA 4R76A 3T8WA 1LAMA 5CB5A 3SIJA 1BPNA 5HIHA 2ACFA 3GPQA 1TY8A
chains in the Genus database with same CATH topology
4J5RA 2DX6A 4JGKA 1BLLE 2BFQA 4J5QA 3EKEA 3EWPA 1ZR5A 3JZTA 3GPOA 5CB3A 4ETKA 3SIGA 2XD7A 3EWQA 3H8EA 3Q6ZA 3EW5A 4D86A 4GVWA 5DUSA 4K0CA 2J9AA 3GQEA 3Q71A 4JVVA 3KQXA 2EWBA 3VFQA 4KSIA 1GYTA 4K3NA 4ESSA 3KR5A 4ZY2A 2FXKA 2AFCA 4GUAA 1YD9A 4J5SA 5E3BA 4ZX9A 5FSZA 3IJ3A 3V45A 3V2BA 3EJGA 4ETJA 4ZI6A 1SPVA 3IIFA 3JRUA 2X47A 1NJRA 4ABLA 2BFRA 3H8GA 4IQYA 4JCAA 4UMLA 5FSVA 1VHUA 4R7MA 1LAPA 5CMSA 4ZY0A 5AILA 1LANA 2VRIA 4X2TA 2L8RA 3GPGA 3EWRA 3PEIA 3EJFA 4ZYQA 3KR4A 2FAVA 3H8FA 4GVVA 3SIIA 1BPMA 2FG1A 2EEEA 4J4ZA 1ZR3A 3GQOA 3KZWA 5CBMA 5FSYA 3EWOA 5FSUA 4ZY1A 5FSXA 4ABKA 3SIHA 3ETIA 1LCPA 3KQZA 4JLLA 3IIDA 5D8NA 4ZX8A 5HOLA 1TXZA 4TU0A 1HJZA 4KYBA 2LGRA 4R6TA 4R76A 3T8WA 1LAMA 5CB5A 3SIJA 1BPNA 5HIHA 2ACFA 3GPQA 1TY8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J5R A;  2DX6 A;  4JGK A;  1BLL E;  2BFQ A;  4J5Q A;  3EKE A;  3EWP A;  1ZR5 A;  3JZT A;  3GPO A;  5CB3 A;  4ETK A;  3SIG A;  2XD7 A;  3EWQ A;  3H8E A;  3Q6Z A;  3EW5 A;  4D86 A;  4GVW A;  5DUS A;  4K0C A;  2J9A A;  3GQE A;  3Q71 A;  4JVV A;  3KQX A;  2EWB A;  3VFQ A;  4KSI A;  1GYT A;  4K3N A;  4ESS A;  3KR5 A;  4ZY2 A;  2FXK A;  2AFC A;  4GUA A;  1YD9 A;  4J5S A;  5E3B A;  4ZX9 A;  5FSZ A;  3IJ3 A;  3V45 A;  3V2B A;  3EJG A;  4ETJ A;  4ZI6 A;  1SPV A;  3IIF A;  3JRU A;  2X47 A;  1NJR A;  4ABL A;  2BFR A;  3H8G A;  4IQY A;  4JCA A;  4UML A;  5FSV A;  1VHU A;  4R7M A;  1LAP A;  5CMS A;  4ZY0 A;  5AIL A;  1LAN A;  2VRI A;  4X2T A;  2L8R A;  3GPG A;  3EWR A;  3PEI A;  3EJF A;  4ZYQ A;  3KR4 A;  2FAV A;  3H8F A;  4GVV A;  3SII A;  1BPM A;  2FG1 A;  2EEE A;  4J4Z A;  1ZR3 A;  3GQO A;  3KZW A;  5CBM A;  5FSY A;  3EWO A;  5FSU A;  4ZY1 A;  5FSX A;  4ABK A;  3SIH A;  3ETI A;  1LCP A;  3KQZ A;  4JLL A;  3IID A;  5D8N A;  4ZX8 A;  5HOL A;  1TXZ A;  4TU0 A;  1HJZ A;  4KYB A;  2LGR A;  4R6T A;  4R76 A;  3T8W A;  1LAM A;  5CB5 A;  3SIJ A;  1BPN A;  5HIH A;  2ACF A;  3GPQ A;  1TY8 A; 
#chains in the Genus database with same CATH topology
 4J5R A;  2DX6 A;  2JZE A;  4JGK A;  1BLL E;  2BFQ A;  4J5Q A;  3EKE A;  2KQV A;  3EWP A;  2WCT A;  1ZR5 A;  3JZT A;  3GPO A;  5CB3 A;  4ETK A;  3SIG A;  2XD7 A;  2JZD A;  3EWQ A;  3H8E A;  3Q6Z A;  3EW5 A;  4D86 A;  4GVW A;  5DUS A;  4K0C A;  2J9A A;  3GQE A;  3Q71 A;  4JVV A;  3KQX A;  2EWB A;  3VFQ A;  4KSI A;  1GYT A;  4K3N A;  4ESS A;  3KR5 A;  4ZY2 A;  2FXK A;  2AFC A;  4GUA A;  1YD9 A;  4J5S A;  5E3B A;  4ZX9 A;  5FSZ A;  3IJ3 A;  3V45 A;  3V2B A;  2RNK A;  3EJG A;  4ETJ A;  4ZI6 A;  1SPV A;  3IIF A;  3JRU A;  2X47 A;  1NJR A;  4ABL A;  2BFR A;  3H8G A;  4IQY A;  4JCA A;  4UML A;  5FSV A;  1VHU A;  4R7M A;  1LAP A;  5CMS A;  4ZY0 A;  5AIL A;  1LAN A;  2VRI A;  4X2T A;  2L8R A;  3GPG A;  3EWR A;  3PEI A;  3EJF A;  4ZYQ A;  3KR4 A;  2FAV A;  3H8F A;  4GVV A;  3SII A;  2W2G A;  1BPM A;  2FG1 A;  2EEE A;  4J4Z A;  1ZR3 A;  3GQO A;  3KZW A;  5CBM A;  5FSY A;  3EWO A;  5FSU A;  4ZY1 A;  5FSX A;  4ABK A;  3SIH A;  3ETI A;  1LCP A;  3KQZ A;  4JLL A;  3IID A;  5D8N A;  4ZX8 A;  5HOL A;  1TXZ A;  4TU0 A;  1HJZ A;  4KYB A;  2JZF A;  2LGR A;  4R6T A;  4R76 A;  3T8W A;  1LAM A;  5CB5 A;  3SIJ A;  1BPN A;  5HIH A;  2ACF A;  3GPQ A;  1TY8 A; 
#chains in the Genus database with same CATH homology
 4J5R A;  2DX6 A;  4JGK A;  1BLL E;  2BFQ A;  4J5Q A;  3EKE A;  3EWP A;  1ZR5 A;  3JZT A;  3GPO A;  5CB3 A;  4ETK A;  3SIG A;  2XD7 A;  3EWQ A;  3H8E A;  3Q6Z A;  3EW5 A;  4D86 A;  4GVW A;  5DUS A;  4K0C A;  2J9A A;  3GQE A;  3Q71 A;  4JVV A;  3KQX A;  2EWB A;  3VFQ A;  4KSI A;  1GYT A;  4K3N A;  4ESS A;  3KR5 A;  4ZY2 A;  2FXK A;  2AFC A;  4GUA A;  1YD9 A;  4J5S A;  5E3B A;  4ZX9 A;  5FSZ A;  3IJ3 A;  3V45 A;  3V2B A;  3EJG A;  4ETJ A;  4ZI6 A;  1SPV A;  3IIF A;  3JRU A;  2X47 A;  1NJR A;  4ABL A;  2BFR A;  3H8G A;  4IQY A;  4JCA A;  4UML A;  5FSV A;  1VHU A;  4R7M A;  1LAP A;  5CMS A;  4ZY0 A;  5AIL A;  1LAN A;  2VRI A;  4X2T A;  2L8R A;  3GPG A;  3EWR A;  3PEI A;  3EJF A;  4ZYQ A;  3KR4 A;  2FAV A;  3H8F A;  4GVV A;  3SII A;  1BPM A;  2FG1 A;  2EEE A;  4J4Z A;  1ZR3 A;  3GQO A;  3KZW A;  5CBM A;  5FSY A;  3EWO A;  5FSU A;  4ZY1 A;  5FSX A;  4ABK A;  3SIH A;  3ETI A;  1LCP A;  3KQZ A;  4JLL A;  3IID A;  5D8N A;  4ZX8 A;  5HOL A;  1TXZ A;  4TU0 A;  1HJZ A;  4KYB A;  2LGR A;  4R6T A;  4R76 A;  3T8W A;  1LAM A;  5CB5 A;  3SIJ A;  1BPN A;  5HIH A;  2ACF A;  3GPQ A;  1TY8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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