4IQYA

Crystal structure of the human protein-proximal adp-ribosyl-hydrolase macrod2
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
232
structure length
221
Chain Sequence
VWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKNTQEKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords O-acetyl-ADP-ribose deacetylase MACROD2
publication title A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 74
structure length 221
sequence length 232
chains with identical sequence B
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 4iqyA00
3KR4A 1ZR5A 2LGRA 4X2TA 1TXZA 3EWPA 4ZX8A 5AILA 4ESSA 4JLLA 3EKEA 4ZX9A 1BLLE 3H8GA 5CMSA 4ZI6A 1LAMA 3EW5A 5HIHA 2X47A 4ZY0A 2VRIA 3GQEA 3VFQA 3KQZA 4ZY1A 2EEEA 2XD7A 1LAPA 2L8RA 3V45A 5CB5A 3H8EA 3GPQA 3KZWA 4KYBA 4J5QA 5FSUA 1BPMA 2BFRA 3EJGA 4IQYA 4ETKA 3EWOA 4GVVA 5DUSA 5CB3A 3GPOA 3KQXA 4ZY2A 4R6TA 1ZR3A 1TY8A 4J5RA 4JGKA 3Q71A 4J5SA 4KSIA 4R76A 1SPVA 4JVVA 4K0CA 1BPNA 1HJZA 3EWRA 5FSYA 2AFCA 4ABLA 1VHUA 3IIDA 1LCPA 3V2BA 4ETJA 2FG1A 5FSXA 3ETIA 2EWBA 1GYTA 5FSVA 1YD9A 3GQOA 4UMLA 4ABKA 2DX6A 3SIHA 5HOLA 3SIIA 2FXKA 4TU0A 3KR5A 4D86A 2J9AA 2BFQA 3EWQA 4K3NA 3IIFA 5FSZA 3GPGA 1NJRA 3H8FA 2FAVA 4ZYQA 4J4ZA 3Q6ZA 3EJFA 1LANA 4GUAA 3JRUA 4JCAA 5E3BA 3PEIA 4R7MA 4GVWA 2ACFA 3IJ3A 5CBMA 3SIGA 3SIJA 3T8WA 3JZTA 5D8NA
chains in the Genus database with same CATH superfamily
3KR4A 1ZR5A 2LGRA 4X2TA 1TXZA 3EWPA 4ZX8A 5AILA 4ESSA 4JLLA 3EKEA 4ZX9A 1BLLE 3H8GA 5CMSA 4ZI6A 1LAMA 3EW5A 5HIHA 2X47A 4ZY0A 2VRIA 3GQEA 3VFQA 3KQZA 4ZY1A 2EEEA 2XD7A 1LAPA 2L8RA 3V45A 5CB5A 3H8EA 3GPQA 3KZWA 4KYBA 4J5QA 5FSUA 1BPMA 2BFRA 2JZEA 3EJGA 4IQYA 4ETKA 2RNKA 3EWOA 4GVVA 5DUSA 5CB3A 3GPOA 3KQXA 4ZY2A 4R6TA 1ZR3A 1TY8A 4J5RA 4JGKA 3Q71A 4J5SA 4KSIA 4R76A 1SPVA 2JZFA 4JVVA 4K0CA 1BPNA 1HJZA 3EWRA 5FSYA 2AFCA 4ABLA 1VHUA 3IIDA 1LCPA 3V2BA 4ETJA 2FG1A 5FSXA 3ETIA 2EWBA 1GYTA 5FSVA 1YD9A 3GQOA 4UMLA 4ABKA 2DX6A 2JZDA 3SIHA 5HOLA 2WCTA 3SIIA 2W2GA 2FXKA 4TU0A 3KR5A 4D86A 2J9AA 2BFQA 3EWQA 4K3NA 3IIFA 5FSZA 3GPGA 2KQVA 1NJRA 3H8FA 2FAVA 4ZYQA 4J4ZA 3Q6ZA 3EJFA 1LANA 4GUAA 3JRUA 4JCAA 5E3BA 3PEIA 4R7MA 4GVWA 2ACFA 3IJ3A 5CBMA 3SIGA 3SIJA 3T8WA 3JZTA 5D8NA
chains in the Genus database with same CATH topology
3KR4A 1ZR5A 2LGRA 4X2TA 1TXZA 3EWPA 4ZX8A 5AILA 4ESSA 4JLLA 3EKEA 4ZX9A 1BLLE 3H8GA 5CMSA 4ZI6A 1LAMA 3EW5A 5HIHA 2X47A 4ZY0A 2VRIA 3GQEA 3VFQA 3KQZA 4ZY1A 2EEEA 2XD7A 1LAPA 2L8RA 3V45A 5CB5A 3H8EA 3GPQA 3KZWA 4KYBA 4J5QA 5FSUA 1BPMA 2BFRA 3EJGA 4IQYA 4ETKA 3EWOA 4GVVA 5DUSA 5CB3A 3GPOA 3KQXA 4ZY2A 4R6TA 1ZR3A 1TY8A 4J5RA 4JGKA 3Q71A 4J5SA 4KSIA 4R76A 1SPVA 4JVVA 4K0CA 1BPNA 1HJZA 3EWRA 5FSYA 2AFCA 4ABLA 1VHUA 3IIDA 1LCPA 3V2BA 4ETJA 2FG1A 5FSXA 3ETIA 2EWBA 1GYTA 5FSVA 1YD9A 3GQOA 4UMLA 4ABKA 2DX6A 3SIHA 5HOLA 3SIIA 2FXKA 4TU0A 3KR5A 4D86A 2J9AA 2BFQA 3EWQA 4K3NA 3IIFA 5FSZA 3GPGA 1NJRA 3H8FA 2FAVA 4ZYQA 4J4ZA 3Q6ZA 3EJFA 1LANA 4GUAA 3JRUA 4JCAA 5E3BA 3PEIA 4R7MA 4GVWA 2ACFA 3IJ3A 5CBMA 3SIGA 3SIJA 3T8WA 3JZTA 5D8NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KR4 A;  1ZR5 A;  2LGR A;  4X2T A;  1TXZ A;  3EWP A;  4ZX8 A;  5AIL A;  4ESS A;  4JLL A;  3EKE A;  4ZX9 A;  1BLL E;  3H8G A;  5CMS A;  4ZI6 A;  1LAM A;  3EW5 A;  5HIH A;  2X47 A;  4ZY0 A;  2VRI A;  3GQE A;  3VFQ A;  3KQZ A;  4ZY1 A;  2EEE A;  2XD7 A;  1LAP A;  2L8R A;  3V45 A;  5CB5 A;  3H8E A;  3GPQ A;  3KZW A;  4KYB A;  4J5Q A;  5FSU A;  1BPM A;  2BFR A;  3EJG A;  4IQY A;  4ETK A;  3EWO A;  4GVV A;  5DUS A;  5CB3 A;  3GPO A;  3KQX A;  4ZY2 A;  4R6T A;  1ZR3 A;  1TY8 A;  4J5R A;  4JGK A;  3Q71 A;  4J5S A;  4KSI A;  4R76 A;  1SPV A;  4JVV A;  4K0C A;  1BPN A;  1HJZ A;  3EWR A;  5FSY A;  2AFC A;  4ABL A;  1VHU A;  3IID A;  1LCP A;  3V2B A;  4ETJ A;  2FG1 A;  5FSX A;  3ETI A;  2EWB A;  1GYT A;  5FSV A;  1YD9 A;  3GQO A;  4UML A;  4ABK A;  2DX6 A;  3SIH A;  5HOL A;  3SII A;  2FXK A;  4TU0 A;  3KR5 A;  4D86 A;  2J9A A;  2BFQ A;  3EWQ A;  4K3N A;  3IIF A;  5FSZ A;  3GPG A;  1NJR A;  3H8F A;  2FAV A;  4ZYQ A;  4J4Z A;  3Q6Z A;  3EJF A;  1LAN A;  4GUA A;  3JRU A;  4JCA A;  5E3B A;  3PEI A;  4R7M A;  4GVW A;  2ACF A;  3IJ3 A;  5CBM A;  3SIG A;  3SIJ A;  3T8W A;  3JZT A;  5D8N A; 
#chains in the Genus database with same CATH topology
 3KR4 A;  1ZR5 A;  2LGR A;  4X2T A;  1TXZ A;  3EWP A;  4ZX8 A;  5AIL A;  4ESS A;  4JLL A;  3EKE A;  4ZX9 A;  1BLL E;  3H8G A;  5CMS A;  4ZI6 A;  1LAM A;  3EW5 A;  5HIH A;  2X47 A;  4ZY0 A;  2VRI A;  3GQE A;  3VFQ A;  3KQZ A;  4ZY1 A;  2EEE A;  2XD7 A;  1LAP A;  2L8R A;  3V45 A;  5CB5 A;  3H8E A;  3GPQ A;  3KZW A;  4KYB A;  4J5Q A;  5FSU A;  1BPM A;  2BFR A;  2JZE A;  3EJG A;  4IQY A;  4ETK A;  2RNK A;  3EWO A;  4GVV A;  5DUS A;  5CB3 A;  3GPO A;  3KQX A;  4ZY2 A;  4R6T A;  1ZR3 A;  1TY8 A;  4J5R A;  4JGK A;  3Q71 A;  4J5S A;  4KSI A;  4R76 A;  1SPV A;  2JZF A;  4JVV A;  4K0C A;  1BPN A;  1HJZ A;  3EWR A;  5FSY A;  2AFC A;  4ABL A;  1VHU A;  3IID A;  1LCP A;  3V2B A;  4ETJ A;  2FG1 A;  5FSX A;  3ETI A;  2EWB A;  1GYT A;  5FSV A;  1YD9 A;  3GQO A;  4UML A;  4ABK A;  2DX6 A;  2JZD A;  3SIH A;  5HOL A;  2WCT A;  3SII A;  2W2G A;  2FXK A;  4TU0 A;  3KR5 A;  4D86 A;  2J9A A;  2BFQ A;  3EWQ A;  4K3N A;  3IIF A;  5FSZ A;  3GPG A;  2KQV A;  1NJR A;  3H8F A;  2FAV A;  4ZYQ A;  4J4Z A;  3Q6Z A;  3EJF A;  1LAN A;  4GUA A;  3JRU A;  4JCA A;  5E3B A;  3PEI A;  4R7M A;  4GVW A;  2ACF A;  3IJ3 A;  5CBM A;  3SIG A;  3SIJ A;  3T8W A;  3JZT A;  5D8N A; 
#chains in the Genus database with same CATH homology
 3KR4 A;  1ZR5 A;  2LGR A;  4X2T A;  1TXZ A;  3EWP A;  4ZX8 A;  5AIL A;  4ESS A;  4JLL A;  3EKE A;  4ZX9 A;  1BLL E;  3H8G A;  5CMS A;  4ZI6 A;  1LAM A;  3EW5 A;  5HIH A;  2X47 A;  4ZY0 A;  2VRI A;  3GQE A;  3VFQ A;  3KQZ A;  4ZY1 A;  2EEE A;  2XD7 A;  1LAP A;  2L8R A;  3V45 A;  5CB5 A;  3H8E A;  3GPQ A;  3KZW A;  4KYB A;  4J5Q A;  5FSU A;  1BPM A;  2BFR A;  3EJG A;  4IQY A;  4ETK A;  3EWO A;  4GVV A;  5DUS A;  5CB3 A;  3GPO A;  3KQX A;  4ZY2 A;  4R6T A;  1ZR3 A;  1TY8 A;  4J5R A;  4JGK A;  3Q71 A;  4J5S A;  4KSI A;  4R76 A;  1SPV A;  4JVV A;  4K0C A;  1BPN A;  1HJZ A;  3EWR A;  5FSY A;  2AFC A;  4ABL A;  1VHU A;  3IID A;  1LCP A;  3V2B A;  4ETJ A;  2FG1 A;  5FSX A;  3ETI A;  2EWB A;  1GYT A;  5FSV A;  1YD9 A;  3GQO A;  4UML A;  4ABK A;  2DX6 A;  3SIH A;  5HOL A;  3SII A;  2FXK A;  4TU0 A;  3KR5 A;  4D86 A;  2J9A A;  2BFQ A;  3EWQ A;  4K3N A;  3IIF A;  5FSZ A;  3GPG A;  1NJR A;  3H8F A;  2FAV A;  4ZYQ A;  4J4Z A;  3Q6Z A;  3EJF A;  1LAN A;  4GUA A;  3JRU A;  4JCA A;  5E3B A;  3PEI A;  4R7M A;  4GVW A;  2ACF A;  3IJ3 A;  5CBM A;  3SIG A;  3SIJ A;  3T8W A;  3JZT A;  5D8N A; 
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similar chains in the Genus database (?% sequence similarity)
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