4JLLA

Crystal structure of the evolved variant of the computationally designed serine hydrolase, osh55.4_h1 covalently bound with fp-alkyne, northeast structural genomics consortium (nesg) target or273
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
161
structure length
161
Chain Sequence
ARIRHVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTSWGAWVGGLPAEAVHRVMGEEIKKAPDTLEVTGVHGTEKSAEAYRRASLEH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design of activated serine-containing catalytic triads with atomic-level accuracy.
pubmed doi rcsb
molecule tags Structural genomics, unknown function
source organism Synthetic construct
molecule keywords Evolved variant of computationally designed serine hydrolase
total genus 57
structure length 161
sequence length 161
ec nomenclature
pdb deposition date 2013-03-12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 4jllA00
2EEEA 3IIFA 3GQEA 1SPVA 5HOLA 3VFQA 1NJRA 5DUSA 4ZI6A 5FSZA 2FAVA 3H8EA 1TY8A 3SIHA 3GQOA 2XD7A 4ZY1A 4J5RA 4ZY0A 4ZX9A 3H8GA 3EWOA 3GPOA 4D86A 4J5SA 4X2TA 3T8WA 1YD9A 3KR4A 4IQYA 3KZWA 5FSXA 2AFCA 3Q6ZA 1ZR5A 2FG1A 3PEIA 1HJZA 2DX6A 3EJFA 1LAPA 3KQZA 3V45A 1LANA 4ABLA 3V2BA 3EWRA 5E3BA 2X47A 4JGKA 1GYTA 4JLLA 5CMSA 5AILA 4ZX8A 2L8RA 4TU0A 3Q71A 4K3NA 4J5QA 3EJGA 5CB5A 4GVWA 5FSVA 3EKEA 2BFQA 2BFRA 5CB3A 3JRUA 2LGRA 3KQXA 4GVVA 2ACFA 4JVVA 3SIJA 1BPNA 3IJ3A 3KR5A 4K0CA 4R7MA 3H8FA 3GPQA 3ETIA 4ZY2A 3SIIA 4KSIA 3SIGA 1LAMA 1BLLE 4J4ZA 1TXZA 3IIDA 1BPMA 4UMLA 4ZYQA 2J9AA 4KYBA 2EWBA 3EWPA 3EWQA 5D8NA 3JZTA 5FSUA 3EW5A 4JCAA 2FXKA 1ZR3A 5HIHA 2VRIA 4GUAA 1LCPA 4ETJA 3GPGA 4ESSA 5CBMA 5FSYA 4R6TA 4R76A 4ABKA 1VHUA 4ETKA
chains in the Genus database with same CATH superfamily
2EEEA 3IIFA 3GQEA 1SPVA 5HOLA 3VFQA 1NJRA 5DUSA 4ZI6A 5FSZA 2FAVA 3H8EA 1TY8A 3SIHA 3GQOA 2XD7A 4ZY1A 4J5RA 4ZY0A 4ZX9A 3H8GA 3EWOA 3GPOA 4D86A 4J5SA 4X2TA 3T8WA 1YD9A 3KR4A 4IQYA 3KZWA 5FSXA 2AFCA 3Q6ZA 1ZR5A 2FG1A 3PEIA 1HJZA 2DX6A 3EJFA 1LAPA 3KQZA 3V45A 1LANA 4ABLA 3V2BA 2W2GA 3EWRA 5E3BA 2X47A 4JGKA 1GYTA 4JLLA 5CMSA 5AILA 4ZX8A 2L8RA 4TU0A 3Q71A 4K3NA 2WCTA 4J5QA 3EJGA 5CB5A 4GVWA 5FSVA 3EKEA 2BFQA 2JZDA 2BFRA 5CB3A 3JRUA 2LGRA 3KQXA 4GVVA 2ACFA 2RNKA 4JVVA 3SIJA 2KQVA 1BPNA 3IJ3A 3KR5A 4K0CA 4R7MA 3H8FA 3GPQA 3ETIA 4ZY2A 3SIIA 4KSIA 3SIGA 1LAMA 1BLLE 4J4ZA 1TXZA 3IIDA 1BPMA 2JZFA 4UMLA 4ZYQA 2J9AA 4KYBA 2EWBA 3EWPA 3EWQA 5D8NA 3JZTA 5FSUA 3EW5A 4JCAA 2FXKA 1ZR3A 5HIHA 2JZEA 2VRIA 4GUAA 1LCPA 4ETJA 3GPGA 4ESSA 5CBMA 5FSYA 4R6TA 4R76A 4ABKA 1VHUA 4ETKA
chains in the Genus database with same CATH topology
2EEEA 3IIFA 3GQEA 1SPVA 5HOLA 3VFQA 1NJRA 5DUSA 4ZI6A 5FSZA 2FAVA 3H8EA 1TY8A 3SIHA 3GQOA 2XD7A 4ZY1A 4J5RA 4ZY0A 4ZX9A 3H8GA 3EWOA 3GPOA 4D86A 4J5SA 4X2TA 3T8WA 1YD9A 3KR4A 4IQYA 3KZWA 5FSXA 2AFCA 3Q6ZA 1ZR5A 2FG1A 3PEIA 1HJZA 2DX6A 3EJFA 1LAPA 3KQZA 3V45A 1LANA 4ABLA 3V2BA 3EWRA 5E3BA 2X47A 4JGKA 1GYTA 4JLLA 5CMSA 5AILA 4ZX8A 2L8RA 4TU0A 3Q71A 4K3NA 4J5QA 3EJGA 5CB5A 4GVWA 5FSVA 3EKEA 2BFQA 2BFRA 5CB3A 3JRUA 2LGRA 3KQXA 4GVVA 2ACFA 4JVVA 3SIJA 1BPNA 3IJ3A 3KR5A 4K0CA 4R7MA 3H8FA 3GPQA 3ETIA 4ZY2A 3SIIA 4KSIA 3SIGA 1LAMA 1BLLE 4J4ZA 1TXZA 3IIDA 1BPMA 4UMLA 4ZYQA 2J9AA 4KYBA 2EWBA 3EWPA 3EWQA 5D8NA 3JZTA 5FSUA 3EW5A 4JCAA 2FXKA 1ZR3A 5HIHA 2VRIA 4GUAA 1LCPA 4ETJA 3GPGA 4ESSA 5CBMA 5FSYA 4R6TA 4R76A 4ABKA 1VHUA 4ETKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EEE A;  3IIF A;  3GQE A;  1SPV A;  5HOL A;  3VFQ A;  1NJR A;  5DUS A;  4ZI6 A;  5FSZ A;  2FAV A;  3H8E A;  1TY8 A;  3SIH A;  3GQO A;  2XD7 A;  4ZY1 A;  4J5R A;  4ZY0 A;  4ZX9 A;  3H8G A;  3EWO A;  3GPO A;  4D86 A;  4J5S A;  4X2T A;  3T8W A;  1YD9 A;  3KR4 A;  4IQY A;  3KZW A;  5FSX A;  2AFC A;  3Q6Z A;  1ZR5 A;  2FG1 A;  3PEI A;  1HJZ A;  2DX6 A;  3EJF A;  1LAP A;  3KQZ A;  3V45 A;  1LAN A;  4ABL A;  3V2B A;  3EWR A;  5E3B A;  2X47 A;  4JGK A;  1GYT A;  4JLL A;  5CMS A;  5AIL A;  4ZX8 A;  2L8R A;  4TU0 A;  3Q71 A;  4K3N A;  4J5Q A;  3EJG A;  5CB5 A;  4GVW A;  5FSV A;  3EKE A;  2BFQ A;  2BFR A;  5CB3 A;  3JRU A;  2LGR A;  3KQX A;  4GVV A;  2ACF A;  4JVV A;  3SIJ A;  1BPN A;  3IJ3 A;  3KR5 A;  4K0C A;  4R7M A;  3H8F A;  3GPQ A;  3ETI A;  4ZY2 A;  3SII A;  4KSI A;  3SIG A;  1LAM A;  1BLL E;  4J4Z A;  1TXZ A;  3IID A;  1BPM A;  4UML A;  4ZYQ A;  2J9A A;  4KYB A;  2EWB A;  3EWP A;  3EWQ A;  5D8N A;  3JZT A;  5FSU A;  3EW5 A;  4JCA A;  2FXK A;  1ZR3 A;  5HIH A;  2VRI A;  4GUA A;  1LCP A;  4ETJ A;  3GPG A;  4ESS A;  5CBM A;  5FSY A;  4R6T A;  4R76 A;  4ABK A;  1VHU A;  4ETK A; 
#chains in the Genus database with same CATH topology
 2EEE A;  3IIF A;  3GQE A;  1SPV A;  5HOL A;  3VFQ A;  1NJR A;  5DUS A;  4ZI6 A;  5FSZ A;  2FAV A;  3H8E A;  1TY8 A;  3SIH A;  3GQO A;  2XD7 A;  4ZY1 A;  4J5R A;  4ZY0 A;  4ZX9 A;  3H8G A;  3EWO A;  3GPO A;  4D86 A;  4J5S A;  4X2T A;  3T8W A;  1YD9 A;  3KR4 A;  4IQY A;  3KZW A;  5FSX A;  2AFC A;  3Q6Z A;  1ZR5 A;  2FG1 A;  3PEI A;  1HJZ A;  2DX6 A;  3EJF A;  1LAP A;  3KQZ A;  3V45 A;  1LAN A;  4ABL A;  3V2B A;  2W2G A;  3EWR A;  5E3B A;  2X47 A;  4JGK A;  1GYT A;  4JLL A;  5CMS A;  5AIL A;  4ZX8 A;  2L8R A;  4TU0 A;  3Q71 A;  4K3N A;  2WCT A;  4J5Q A;  3EJG A;  5CB5 A;  4GVW A;  5FSV A;  3EKE A;  2BFQ A;  2JZD A;  2BFR A;  5CB3 A;  3JRU A;  2LGR A;  3KQX A;  4GVV A;  2ACF A;  2RNK A;  4JVV A;  3SIJ A;  2KQV A;  1BPN A;  3IJ3 A;  3KR5 A;  4K0C A;  4R7M A;  3H8F A;  3GPQ A;  3ETI A;  4ZY2 A;  3SII A;  4KSI A;  3SIG A;  1LAM A;  1BLL E;  4J4Z A;  1TXZ A;  3IID A;  1BPM A;  2JZF A;  4UML A;  4ZYQ A;  2J9A A;  4KYB A;  2EWB A;  3EWP A;  3EWQ A;  5D8N A;  3JZT A;  5FSU A;  3EW5 A;  4JCA A;  2FXK A;  1ZR3 A;  5HIH A;  2JZE A;  2VRI A;  4GUA A;  1LCP A;  4ETJ A;  3GPG A;  4ESS A;  5CBM A;  5FSY A;  4R6T A;  4R76 A;  4ABK A;  1VHU A;  4ETK A; 
#chains in the Genus database with same CATH homology
 2EEE A;  3IIF A;  3GQE A;  1SPV A;  5HOL A;  3VFQ A;  1NJR A;  5DUS A;  4ZI6 A;  5FSZ A;  2FAV A;  3H8E A;  1TY8 A;  3SIH A;  3GQO A;  2XD7 A;  4ZY1 A;  4J5R A;  4ZY0 A;  4ZX9 A;  3H8G A;  3EWO A;  3GPO A;  4D86 A;  4J5S A;  4X2T A;  3T8W A;  1YD9 A;  3KR4 A;  4IQY A;  3KZW A;  5FSX A;  2AFC A;  3Q6Z A;  1ZR5 A;  2FG1 A;  3PEI A;  1HJZ A;  2DX6 A;  3EJF A;  1LAP A;  3KQZ A;  3V45 A;  1LAN A;  4ABL A;  3V2B A;  3EWR A;  5E3B A;  2X47 A;  4JGK A;  1GYT A;  4JLL A;  5CMS A;  5AIL A;  4ZX8 A;  2L8R A;  4TU0 A;  3Q71 A;  4K3N A;  4J5Q A;  3EJG A;  5CB5 A;  4GVW A;  5FSV A;  3EKE A;  2BFQ A;  2BFR A;  5CB3 A;  3JRU A;  2LGR A;  3KQX A;  4GVV A;  2ACF A;  4JVV A;  3SIJ A;  1BPN A;  3IJ3 A;  3KR5 A;  4K0C A;  4R7M A;  3H8F A;  3GPQ A;  3ETI A;  4ZY2 A;  3SII A;  4KSI A;  3SIG A;  1LAM A;  1BLL E;  4J4Z A;  1TXZ A;  3IID A;  1BPM A;  4UML A;  4ZYQ A;  2J9A A;  4KYB A;  2EWB A;  3EWP A;  3EWQ A;  5D8N A;  3JZT A;  5FSU A;  3EW5 A;  4JCA A;  2FXK A;  1ZR3 A;  5HIH A;  2VRI A;  4GUA A;  1LCP A;  4ETJ A;  3GPG A;  4ESS A;  5CBM A;  5FSY A;  4R6T A;  4R76 A;  4ABK A;  1VHU A;  4ETK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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