3VFQA

Human parp14 (artd8, bal2) - macro domains 1 and 2 in complex with adenosine-5-diphosphoribose
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
401
structure length
375
Chain Sequence
KCFSRTVLAPGVVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQLKTLQEVHFLLHPSDHENIQAFSDEFARRAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Poly [ADP-ribose] polymerase 14
total genus 122
structure length 375
sequence length 401
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 3vfqA02
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 3vfqA01
4ETKA 1LAMA 1YD9A 3IIFA 4R7MA 3EKEA 1BPNA 4TU0A 5D8NA 3GQOA 3Q6ZA 4ZY2A 1BLLE 5FSXA 2BFQA 4GUAA 2LGRA 3EWRA 1ZR5A 2BFRA 3EWQA 2ACFA 4KYBA 4J5RA 4ABKA 3GPOA 3KQXA 5HOLA 1TXZA 4ZI6A 3SIJA 2FAVA 1GYTA 1NJRA 2XD7A 2X47A 4ZY0A 1LCPA 4ZX8A 5DUSA 5CBMA 5FSYA 3T8WA 4JCAA 5CB3A 3GPGA 1HJZA 4JVVA 5E3BA 1BPMA 4KSIA 3EWOA 1SPVA 3KQZA 3SIGA 4ZX9A 3GQEA 5AILA 4ABLA 4X2TA 1LANA 3SIHA 3V2BA 3KR4A 1ZR3A 3PEIA 2VRIA 4UMLA 5CMSA 4R6TA 2DX6A 4J4ZA 5CB5A 4ZY1A 2EWBA 3Q71A 4ETJA 2FG1A 3KR5A 5FSUA 4JGKA 3EJFA 4GVWA 3ETIA 1LAPA 2L8RA 4ZYQA 2AFCA 4D86A 4J5SA 4J5QA 5FSZA 1TY8A 3EJGA 3IJ3A 4GVVA 4IQYA 4ESSA 4K3NA 2J9AA 4K0CA 4R76A 3VFQA 3H8FA 2FXKA 3EW5A 5FSVA 3JRUA 3H8EA 2EEEA 4JLLA 3SIIA 3EWPA 3H8GA 3JZTA 1VHUA 3KZWA 5HIHA 3V45A 3GPQA 3IIDA
chains in the Genus database with same CATH superfamily
2WCTA 4ETKA 1LAMA 2JZFA 1YD9A 3IIFA 4R7MA 3EKEA 1BPNA 4TU0A 5D8NA 3GQOA 3Q6ZA 4ZY2A 1BLLE 5FSXA 2BFQA 4GUAA 2LGRA 3EWRA 1ZR5A 2BFRA 3EWQA 2ACFA 4KYBA 4J5RA 4ABKA 3GPOA 3KQXA 5HOLA 1TXZA 4ZI6A 3SIJA 2FAVA 1GYTA 1NJRA 2XD7A 2X47A 4ZY0A 1LCPA 4ZX8A 5DUSA 5CBMA 5FSYA 3T8WA 4JCAA 5CB3A 3GPGA 1HJZA 4JVVA 5E3BA 1BPMA 4KSIA 3EWOA 1SPVA 3KQZA 3SIGA 4ZX9A 3GQEA 5AILA 4ABLA 4X2TA 1LANA 3SIHA 3V2BA 3KR4A 1ZR3A 3PEIA 2VRIA 4UMLA 5CMSA 4R6TA 2DX6A 4J4ZA 5CB5A 4ZY1A 2EWBA 3Q71A 4ETJA 2FG1A 3KR5A 5FSUA 4JGKA 2KQVA 3EJFA 4GVWA 3ETIA 1LAPA 2L8RA 4ZYQA 2AFCA 4D86A 4J5SA 2JZEA 4J5QA 5FSZA 1TY8A 2RNKA 3EJGA 3IJ3A 4GVVA 4IQYA 4ESSA 4K3NA 2J9AA 4K0CA 4R76A 3VFQA 2W2GA 3H8FA 2FXKA 3EW5A 5FSVA 3JRUA 3H8EA 2EEEA 4JLLA 3SIIA 3EWPA 3H8GA 2JZDA 3JZTA 1VHUA 3KZWA 5HIHA 3V45A 3GPQA 3IIDA
chains in the Genus database with same CATH topology
4ETKA 1LAMA 1YD9A 3IIFA 4R7MA 3EKEA 1BPNA 4TU0A 5D8NA 3GQOA 3Q6ZA 4ZY2A 1BLLE 5FSXA 2BFQA 4GUAA 2LGRA 3EWRA 1ZR5A 2BFRA 3EWQA 2ACFA 4KYBA 4J5RA 4ABKA 3GPOA 3KQXA 5HOLA 1TXZA 4ZI6A 3SIJA 2FAVA 1GYTA 1NJRA 2XD7A 2X47A 4ZY0A 1LCPA 4ZX8A 5DUSA 5CBMA 5FSYA 3T8WA 4JCAA 5CB3A 3GPGA 1HJZA 4JVVA 5E3BA 1BPMA 4KSIA 3EWOA 1SPVA 3KQZA 3SIGA 4ZX9A 3GQEA 5AILA 4ABLA 4X2TA 1LANA 3SIHA 3V2BA 3KR4A 1ZR3A 3PEIA 2VRIA 4UMLA 5CMSA 4R6TA 2DX6A 4J4ZA 5CB5A 4ZY1A 2EWBA 3Q71A 4ETJA 2FG1A 3KR5A 5FSUA 4JGKA 3EJFA 4GVWA 3ETIA 1LAPA 2L8RA 4ZYQA 2AFCA 4D86A 4J5SA 4J5QA 5FSZA 1TY8A 3EJGA 3IJ3A 4GVVA 4IQYA 4ESSA 4K3NA 2J9AA 4K0CA 4R76A 3VFQA 3H8FA 2FXKA 3EW5A 5FSVA 3JRUA 3H8EA 2EEEA 4JLLA 3SIIA 3EWPA 3H8GA 3JZTA 1VHUA 3KZWA 5HIHA 3V45A 3GPQA 3IIDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ETK A;  1LAM A;  1YD9 A;  3IIF A;  4R7M A;  3EKE A;  1BPN A;  4TU0 A;  5D8N A;  3GQO A;  3Q6Z A;  4ZY2 A;  1BLL E;  5FSX A;  2BFQ A;  4GUA A;  2LGR A;  3EWR A;  1ZR5 A;  2BFR A;  3EWQ A;  2ACF A;  4KYB A;  4J5R A;  4ABK A;  3GPO A;  3KQX A;  5HOL A;  1TXZ A;  4ZI6 A;  3SIJ A;  2FAV A;  1GYT A;  1NJR A;  2XD7 A;  2X47 A;  4ZY0 A;  1LCP A;  4ZX8 A;  5DUS A;  5CBM A;  5FSY A;  3T8W A;  4JCA A;  5CB3 A;  3GPG A;  1HJZ A;  4JVV A;  5E3B A;  1BPM A;  4KSI A;  3EWO A;  1SPV A;  3KQZ A;  3SIG A;  4ZX9 A;  3GQE A;  5AIL A;  4ABL A;  4X2T A;  1LAN A;  3SIH A;  3V2B A;  3KR4 A;  1ZR3 A;  3PEI A;  2VRI A;  4UML A;  5CMS A;  4R6T A;  2DX6 A;  4J4Z A;  5CB5 A;  4ZY1 A;  2EWB A;  3Q71 A;  4ETJ A;  2FG1 A;  3KR5 A;  5FSU A;  4JGK A;  3EJF A;  4GVW A;  3ETI A;  1LAP A;  2L8R A;  4ZYQ A;  2AFC A;  4D86 A;  4J5S A;  4J5Q A;  5FSZ A;  1TY8 A;  3EJG A;  3IJ3 A;  4GVV A;  4IQY A;  4ESS A;  4K3N A;  2J9A A;  4K0C A;  4R76 A;  3VFQ A;  3H8F A;  2FXK A;  3EW5 A;  5FSV A;  3JRU A;  3H8E A;  2EEE A;  4JLL A;  3SII A;  3EWP A;  3H8G A;  3JZT A;  1VHU A;  3KZW A;  5HIH A;  3V45 A;  3GPQ A;  3IID A; 
#chains in the Genus database with same CATH topology
 2WCT A;  4ETK A;  1LAM A;  2JZF A;  1YD9 A;  3IIF A;  4R7M A;  3EKE A;  1BPN A;  4TU0 A;  5D8N A;  3GQO A;  3Q6Z A;  4ZY2 A;  1BLL E;  5FSX A;  2BFQ A;  4GUA A;  2LGR A;  3EWR A;  1ZR5 A;  2BFR A;  3EWQ A;  2ACF A;  4KYB A;  4J5R A;  4ABK A;  3GPO A;  3KQX A;  5HOL A;  1TXZ A;  4ZI6 A;  3SIJ A;  2FAV A;  1GYT A;  1NJR A;  2XD7 A;  2X47 A;  4ZY0 A;  1LCP A;  4ZX8 A;  5DUS A;  5CBM A;  5FSY A;  3T8W A;  4JCA A;  5CB3 A;  3GPG A;  1HJZ A;  4JVV A;  5E3B A;  1BPM A;  4KSI A;  3EWO A;  1SPV A;  3KQZ A;  3SIG A;  4ZX9 A;  3GQE A;  5AIL A;  4ABL A;  4X2T A;  1LAN A;  3SIH A;  3V2B A;  3KR4 A;  1ZR3 A;  3PEI A;  2VRI A;  4UML A;  5CMS A;  4R6T A;  2DX6 A;  4J4Z A;  5CB5 A;  4ZY1 A;  2EWB A;  3Q71 A;  4ETJ A;  2FG1 A;  3KR5 A;  5FSU A;  4JGK A;  2KQV A;  3EJF A;  4GVW A;  3ETI A;  1LAP A;  2L8R A;  4ZYQ A;  2AFC A;  4D86 A;  4J5S A;  2JZE A;  4J5Q A;  5FSZ A;  1TY8 A;  2RNK A;  3EJG A;  3IJ3 A;  4GVV A;  4IQY A;  4ESS A;  4K3N A;  2J9A A;  4K0C A;  4R76 A;  3VFQ A;  2W2G A;  3H8F A;  2FXK A;  3EW5 A;  5FSV A;  3JRU A;  3H8E A;  2EEE A;  4JLL A;  3SII A;  3EWP A;  3H8G A;  2JZD A;  3JZT A;  1VHU A;  3KZW A;  5HIH A;  3V45 A;  3GPQ A;  3IID A; 
#chains in the Genus database with same CATH homology
 4ETK A;  1LAM A;  1YD9 A;  3IIF A;  4R7M A;  3EKE A;  1BPN A;  4TU0 A;  5D8N A;  3GQO A;  3Q6Z A;  4ZY2 A;  1BLL E;  5FSX A;  2BFQ A;  4GUA A;  2LGR A;  3EWR A;  1ZR5 A;  2BFR A;  3EWQ A;  2ACF A;  4KYB A;  4J5R A;  4ABK A;  3GPO A;  3KQX A;  5HOL A;  1TXZ A;  4ZI6 A;  3SIJ A;  2FAV A;  1GYT A;  1NJR A;  2XD7 A;  2X47 A;  4ZY0 A;  1LCP A;  4ZX8 A;  5DUS A;  5CBM A;  5FSY A;  3T8W A;  4JCA A;  5CB3 A;  3GPG A;  1HJZ A;  4JVV A;  5E3B A;  1BPM A;  4KSI A;  3EWO A;  1SPV A;  3KQZ A;  3SIG A;  4ZX9 A;  3GQE A;  5AIL A;  4ABL A;  4X2T A;  1LAN A;  3SIH A;  3V2B A;  3KR4 A;  1ZR3 A;  3PEI A;  2VRI A;  4UML A;  5CMS A;  4R6T A;  2DX6 A;  4J4Z A;  5CB5 A;  4ZY1 A;  2EWB A;  3Q71 A;  4ETJ A;  2FG1 A;  3KR5 A;  5FSU A;  4JGK A;  3EJF A;  4GVW A;  3ETI A;  1LAP A;  2L8R A;  4ZYQ A;  2AFC A;  4D86 A;  4J5S A;  4J5Q A;  5FSZ A;  1TY8 A;  3EJG A;  3IJ3 A;  4GVV A;  4IQY A;  4ESS A;  4K3N A;  2J9A A;  4K0C A;  4R76 A;  3VFQ A;  3H8F A;  2FXK A;  3EW5 A;  5FSV A;  3JRU A;  3H8E A;  2EEE A;  4JLL A;  3SII A;  3EWP A;  3H8G A;  3JZT A;  1VHU A;  3KZW A;  5HIH A;  3V45 A;  3GPQ A;  3IID A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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