5FSUA

Crystal structure of trypanosoma brucei macrodomain (crystal form 1)
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
251
structure length
235
Chain Sequence
PFEFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma brucei
molecule keywords MACRODOMAIN
total genus 77
structure length 235
sequence length 251
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsuA00
1HJZA 5CB3A 3KR5A 1BLLE 4KSIA 4K3NA 3KZWA 3T8WA 3EJFA 4ESSA 4JCAA 3EWOA 4ZY0A 1LCPA 4R7MA 3PEIA 4J4ZA 3Q6ZA 3EKEA 2J9AA 1ZR3A 2X47A 2EWBA 3KQXA 5FSYA 2BFRA 1NJRA 2ACFA 4ZX9A 3JZTA 3GPOA 5AILA 3IJ3A 3VFQA 4KYBA 5E3BA 1GYTA 5CMSA 1TXZA 4JGKA 3GPQA 3JRUA 3EWPA 4ABLA 4JVVA 4D86A 3H8EA 2XD7A 3GPGA 3V45A 3EW5A 4JLLA 5FSVA 3SIIA 3Q71A 1SPVA 3EWQA 1LAPA 3V2BA 2L8RA 3SIGA 3SIJA 4GVWA 5HIHA 1TY8A 4K0CA 4ETKA 2EEEA 4ZY1A 4UMLA 2AFCA 3H8GA 2FXKA 3SIHA 1VHUA 1LANA 1LAMA 3IIFA 4IQYA 5FSZA 3KQZA 4GUAA 4TU0A 4ZI6A 3KR4A 1BPNA 4J5RA 4ETJA 1ZR5A 2FG1A 2BFQA 4GVVA 5FSXA 5CBMA 2FAVA 5FSUA 4ZX8A 4X2TA 5D8NA 3EWRA 4J5SA 4ZYQA 5CB5A 4R6TA 1YD9A 2VRIA 4R76A 5DUSA 4ABKA 3EJGA 3H8FA 3ETIA 3GQEA 2LGRA 4J5QA 1BPMA 2DX6A 3GQOA 3IIDA 4ZY2A 5HOLA
chains in the Genus database with same CATH superfamily
1HJZA 5CB3A 3KR5A 1BLLE 4KSIA 4K3NA 3KZWA 3T8WA 3EJFA 4ESSA 4JCAA 3EWOA 4ZY0A 1LCPA 4R7MA 3PEIA 4J4ZA 3Q6ZA 3EKEA 2J9AA 1ZR3A 2X47A 2EWBA 2JZEA 3KQXA 5FSYA 2BFRA 1NJRA 2ACFA 4ZX9A 2JZFA 3JZTA 3GPOA 5AILA 2KQVA 3IJ3A 3VFQA 4KYBA 5E3BA 1GYTA 5CMSA 1TXZA 4JGKA 3GPQA 3JRUA 3EWPA 4ABLA 4JVVA 4D86A 3H8EA 2XD7A 2RNKA 3GPGA 2WCTA 3V45A 3EW5A 4JLLA 5FSVA 3SIIA 3Q71A 1SPVA 3EWQA 1LAPA 3V2BA 2L8RA 3SIGA 3SIJA 4GVWA 5HIHA 1TY8A 4K0CA 4ETKA 2EEEA 4ZY1A 4UMLA 2AFCA 3H8GA 2FXKA 3SIHA 1VHUA 1LANA 1LAMA 3IIFA 4IQYA 5FSZA 3KQZA 4GUAA 4TU0A 4ZI6A 3KR4A 1BPNA 4J5RA 4ETJA 1ZR5A 2FG1A 2BFQA 4GVVA 5FSXA 5CBMA 2FAVA 5FSUA 2JZDA 4ZX8A 4X2TA 5D8NA 3EWRA 4J5SA 4ZYQA 5CB5A 4R6TA 1YD9A 2VRIA 4R76A 5DUSA 4ABKA 3EJGA 3H8FA 3ETIA 3GQEA 2LGRA 4J5QA 1BPMA 2DX6A 3GQOA 3IIDA 4ZY2A 2W2GA 5HOLA
chains in the Genus database with same CATH topology
1HJZA 5CB3A 3KR5A 1BLLE 4KSIA 4K3NA 3KZWA 3T8WA 3EJFA 4ESSA 4JCAA 3EWOA 4ZY0A 1LCPA 4R7MA 3PEIA 4J4ZA 3Q6ZA 3EKEA 2J9AA 1ZR3A 2X47A 2EWBA 3KQXA 5FSYA 2BFRA 1NJRA 2ACFA 4ZX9A 3JZTA 3GPOA 5AILA 3IJ3A 3VFQA 4KYBA 5E3BA 1GYTA 5CMSA 1TXZA 4JGKA 3GPQA 3JRUA 3EWPA 4ABLA 4JVVA 4D86A 3H8EA 2XD7A 3GPGA 3V45A 3EW5A 4JLLA 5FSVA 3SIIA 3Q71A 1SPVA 3EWQA 1LAPA 3V2BA 2L8RA 3SIGA 3SIJA 4GVWA 5HIHA 1TY8A 4K0CA 4ETKA 2EEEA 4ZY1A 4UMLA 2AFCA 3H8GA 2FXKA 3SIHA 1VHUA 1LANA 1LAMA 3IIFA 4IQYA 5FSZA 3KQZA 4GUAA 4TU0A 4ZI6A 3KR4A 1BPNA 4J5RA 4ETJA 1ZR5A 2FG1A 2BFQA 4GVVA 5FSXA 5CBMA 2FAVA 5FSUA 4ZX8A 4X2TA 5D8NA 3EWRA 4J5SA 4ZYQA 5CB5A 4R6TA 1YD9A 2VRIA 4R76A 5DUSA 4ABKA 3EJGA 3H8FA 3ETIA 3GQEA 2LGRA 4J5QA 1BPMA 2DX6A 3GQOA 3IIDA 4ZY2A 5HOLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HJZ A;  5CB3 A;  3KR5 A;  1BLL E;  4KSI A;  4K3N A;  3KZW A;  3T8W A;  3EJF A;  4ESS A;  4JCA A;  3EWO A;  4ZY0 A;  1LCP A;  4R7M A;  3PEI A;  4J4Z A;  3Q6Z A;  3EKE A;  2J9A A;  1ZR3 A;  2X47 A;  2EWB A;  3KQX A;  5FSY A;  2BFR A;  1NJR A;  2ACF A;  4ZX9 A;  3JZT A;  3GPO A;  5AIL A;  3IJ3 A;  3VFQ A;  4KYB A;  5E3B A;  1GYT A;  5CMS A;  1TXZ A;  4JGK A;  3GPQ A;  3JRU A;  3EWP A;  4ABL A;  4JVV A;  4D86 A;  3H8E A;  2XD7 A;  3GPG A;  3V45 A;  3EW5 A;  4JLL A;  5FSV A;  3SII A;  3Q71 A;  1SPV A;  3EWQ A;  1LAP A;  3V2B A;  2L8R A;  3SIG A;  3SIJ A;  4GVW A;  5HIH A;  1TY8 A;  4K0C A;  4ETK A;  2EEE A;  4ZY1 A;  4UML A;  2AFC A;  3H8G A;  2FXK A;  3SIH A;  1VHU A;  1LAN A;  1LAM A;  3IIF A;  4IQY A;  5FSZ A;  3KQZ A;  4GUA A;  4TU0 A;  4ZI6 A;  3KR4 A;  1BPN A;  4J5R A;  4ETJ A;  1ZR5 A;  2FG1 A;  2BFQ A;  4GVV A;  5FSX A;  5CBM A;  2FAV A;  5FSU A;  4ZX8 A;  4X2T A;  5D8N A;  3EWR A;  4J5S A;  4ZYQ A;  5CB5 A;  4R6T A;  1YD9 A;  2VRI A;  4R76 A;  5DUS A;  4ABK A;  3EJG A;  3H8F A;  3ETI A;  3GQE A;  2LGR A;  4J5Q A;  1BPM A;  2DX6 A;  3GQO A;  3IID A;  4ZY2 A;  5HOL A; 
#chains in the Genus database with same CATH topology
 1HJZ A;  5CB3 A;  3KR5 A;  1BLL E;  4KSI A;  4K3N A;  3KZW A;  3T8W A;  3EJF A;  4ESS A;  4JCA A;  3EWO A;  4ZY0 A;  1LCP A;  4R7M A;  3PEI A;  4J4Z A;  3Q6Z A;  3EKE A;  2J9A A;  1ZR3 A;  2X47 A;  2EWB A;  2JZE A;  3KQX A;  5FSY A;  2BFR A;  1NJR A;  2ACF A;  4ZX9 A;  2JZF A;  3JZT A;  3GPO A;  5AIL A;  2KQV A;  3IJ3 A;  3VFQ A;  4KYB A;  5E3B A;  1GYT A;  5CMS A;  1TXZ A;  4JGK A;  3GPQ A;  3JRU A;  3EWP A;  4ABL A;  4JVV A;  4D86 A;  3H8E A;  2XD7 A;  2RNK A;  3GPG A;  2WCT A;  3V45 A;  3EW5 A;  4JLL A;  5FSV A;  3SII A;  3Q71 A;  1SPV A;  3EWQ A;  1LAP A;  3V2B A;  2L8R A;  3SIG A;  3SIJ A;  4GVW A;  5HIH A;  1TY8 A;  4K0C A;  4ETK A;  2EEE A;  4ZY1 A;  4UML A;  2AFC A;  3H8G A;  2FXK A;  3SIH A;  1VHU A;  1LAN A;  1LAM A;  3IIF A;  4IQY A;  5FSZ A;  3KQZ A;  4GUA A;  4TU0 A;  4ZI6 A;  3KR4 A;  1BPN A;  4J5R A;  4ETJ A;  1ZR5 A;  2FG1 A;  2BFQ A;  4GVV A;  5FSX A;  5CBM A;  2FAV A;  5FSU A;  2JZD A;  4ZX8 A;  4X2T A;  5D8N A;  3EWR A;  4J5S A;  4ZYQ A;  5CB5 A;  4R6T A;  1YD9 A;  2VRI A;  4R76 A;  5DUS A;  4ABK A;  3EJG A;  3H8F A;  3ETI A;  3GQE A;  2LGR A;  4J5Q A;  1BPM A;  2DX6 A;  3GQO A;  3IID A;  4ZY2 A;  2W2G A;  5HOL A; 
#chains in the Genus database with same CATH homology
 1HJZ A;  5CB3 A;  3KR5 A;  1BLL E;  4KSI A;  4K3N A;  3KZW A;  3T8W A;  3EJF A;  4ESS A;  4JCA A;  3EWO A;  4ZY0 A;  1LCP A;  4R7M A;  3PEI A;  4J4Z A;  3Q6Z A;  3EKE A;  2J9A A;  1ZR3 A;  2X47 A;  2EWB A;  3KQX A;  5FSY A;  2BFR A;  1NJR A;  2ACF A;  4ZX9 A;  3JZT A;  3GPO A;  5AIL A;  3IJ3 A;  3VFQ A;  4KYB A;  5E3B A;  1GYT A;  5CMS A;  1TXZ A;  4JGK A;  3GPQ A;  3JRU A;  3EWP A;  4ABL A;  4JVV A;  4D86 A;  3H8E A;  2XD7 A;  3GPG A;  3V45 A;  3EW5 A;  4JLL A;  5FSV A;  3SII A;  3Q71 A;  1SPV A;  3EWQ A;  1LAP A;  3V2B A;  2L8R A;  3SIG A;  3SIJ A;  4GVW A;  5HIH A;  1TY8 A;  4K0C A;  4ETK A;  2EEE A;  4ZY1 A;  4UML A;  2AFC A;  3H8G A;  2FXK A;  3SIH A;  1VHU A;  1LAN A;  1LAM A;  3IIF A;  4IQY A;  5FSZ A;  3KQZ A;  4GUA A;  4TU0 A;  4ZI6 A;  3KR4 A;  1BPN A;  4J5R A;  4ETJ A;  1ZR5 A;  2FG1 A;  2BFQ A;  4GVV A;  5FSX A;  5CBM A;  2FAV A;  5FSU A;  4ZX8 A;  4X2T A;  5D8N A;  3EWR A;  4J5S A;  4ZYQ A;  5CB5 A;  4R6T A;  1YD9 A;  2VRI A;  4R76 A;  5DUS A;  4ABK A;  3EJG A;  3H8F A;  3ETI A;  3GQE A;  2LGR A;  4J5Q A;  1BPM A;  2DX6 A;  3GQO A;  3IID A;  4ZY2 A;  5HOL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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