5FSXA

Crystal structure of trypanosoma brucei macrodomain in complex with adp
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
249
structure length
233
Chain Sequence
EFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma brucei
molecule keywords MACRODOMAIN
total genus 79
structure length 233
sequence length 249
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsxA00
3KR4A 3JRUA 4ZX8A 3V2BA 3EWQA 4ETKA 1LCPA 4X2TA 1TXZA 4K0CA 1BPNA 4J5RA 3H8EA 5FSYA 3IIDA 4J5QA 3SIIA 2J9AA 4K3NA 3SIHA 3VFQA 5FSVA 4JGKA 2X47A 3EW5A 1GYTA 5HOLA 3V45A 2BFQA 5D8NA 3SIJA 4KSIA 3KQZA 4ZYQA 4JLLA 3IJ3A 4ESSA 4GVWA 4GVVA 5AILA 3GPQA 3KQXA 3PEIA 3EJGA 3JZTA 2FG1A 3KZWA 5HIHA 4J5SA 4ETJA 3GPOA 4IQYA 3T8WA 4ZY0A 1LAPA 3SIGA 2EWBA 1LAMA 4R6TA 3GQOA 4JCAA 2EEEA 2AFCA 2DX6A 5CB3A 5DUSA 4TU0A 4JVVA 5FSXA 1ZR5A 5CB5A 4GUAA 3IIFA 1ZR3A 4ABKA 1BPMA 3Q71A 1NJRA 4R76A 5CMSA 2FXKA 1LANA 5E3BA 2L8RA 3Q6ZA 3KR5A 3EWOA 2XD7A 3H8FA 4KYBA 1VHUA 2VRIA 2LGRA 4ZI6A 2FAVA 2ACFA 3EWRA 4ZY1A 1YD9A 1SPVA 1TY8A 4ZY2A 5FSUA 4D86A 2BFRA 1BLLE 3ETIA 4R7MA 3GPGA 4ABLA 3EJFA 4ZX9A 3H8GA 5CBMA 3EKEA 3GQEA 3EWPA 4J4ZA 5FSZA 4UMLA 1HJZA
chains in the Genus database with same CATH superfamily
3KR4A 3JRUA 2JZFA 4ZX8A 3EWQA 3V2BA 1LCPA 4ETKA 4X2TA 1TXZA 4K0CA 1BPNA 4J5RA 3H8EA 5FSYA 3IIDA 4J5QA 3SIIA 2J9AA 4K3NA 2KQVA 2W2GA 3SIHA 3VFQA 5FSVA 4JGKA 2X47A 3EW5A 1GYTA 5HOLA 3V45A 2BFQA 5D8NA 3SIJA 4KSIA 3KQZA 2WCTA 4ZYQA 4JLLA 3IJ3A 4ESSA 4GVWA 4GVVA 5AILA 2JZDA 3GPQA 3KQXA 3PEIA 3EJGA 3JZTA 2FG1A 3KZWA 5HIHA 2JZEA 4J5SA 4ETJA 3GPOA 4IQYA 3T8WA 4ZY0A 1LAPA 3SIGA 2EWBA 1LAMA 4R6TA 3GQOA 4JCAA 2EEEA 2AFCA 2DX6A 5CB3A 5DUSA 4TU0A 4JVVA 5FSXA 1ZR5A 5CB5A 4GUAA 3IIFA 1ZR3A 4ABKA 1BPMA 2RNKA 3Q71A 1NJRA 4R76A 5CMSA 2FXKA 1LANA 5E3BA 2L8RA 3Q6ZA 3KR5A 3EWOA 2XD7A 3H8FA 4KYBA 1VHUA 2VRIA 2LGRA 4ZI6A 2FAVA 2ACFA 3EWRA 4ZY1A 1YD9A 1SPVA 1TY8A 4ZY2A 5FSUA 4D86A 2BFRA 1BLLE 3ETIA 4R7MA 3GPGA 4ABLA 3EJFA 4ZX9A 3H8GA 5CBMA 3EKEA 3GQEA 3EWPA 4J4ZA 5FSZA 4UMLA 1HJZA
chains in the Genus database with same CATH topology
3KR4A 3JRUA 4ZX8A 3V2BA 3EWQA 4ETKA 1LCPA 4X2TA 1TXZA 4K0CA 1BPNA 4J5RA 3H8EA 5FSYA 3IIDA 4J5QA 3SIIA 2J9AA 4K3NA 3SIHA 3VFQA 5FSVA 4JGKA 2X47A 3EW5A 1GYTA 5HOLA 3V45A 2BFQA 5D8NA 3SIJA 4KSIA 3KQZA 4ZYQA 4JLLA 3IJ3A 4ESSA 4GVWA 4GVVA 5AILA 3GPQA 3KQXA 3PEIA 3EJGA 3JZTA 2FG1A 3KZWA 5HIHA 4J5SA 4ETJA 3GPOA 4IQYA 3T8WA 4ZY0A 1LAPA 3SIGA 2EWBA 1LAMA 4R6TA 3GQOA 4JCAA 2EEEA 2AFCA 2DX6A 5CB3A 5DUSA 4TU0A 4JVVA 5FSXA 1ZR5A 5CB5A 4GUAA 3IIFA 1ZR3A 4ABKA 1BPMA 3Q71A 1NJRA 4R76A 5CMSA 2FXKA 1LANA 5E3BA 2L8RA 3Q6ZA 3KR5A 3EWOA 2XD7A 3H8FA 4KYBA 1VHUA 2VRIA 2LGRA 4ZI6A 2FAVA 2ACFA 3EWRA 4ZY1A 1YD9A 1SPVA 1TY8A 4ZY2A 5FSUA 4D86A 2BFRA 1BLLE 3ETIA 4R7MA 3GPGA 4ABLA 3EJFA 4ZX9A 3H8GA 5CBMA 3EKEA 3GQEA 3EWPA 4J4ZA 5FSZA 4UMLA 1HJZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KR4 A;  3JRU A;  4ZX8 A;  3V2B A;  3EWQ A;  4ETK A;  1LCP A;  4X2T A;  1TXZ A;  4K0C A;  1BPN A;  4J5R A;  3H8E A;  5FSY A;  3IID A;  4J5Q A;  3SII A;  2J9A A;  4K3N A;  3SIH A;  3VFQ A;  5FSV A;  4JGK A;  2X47 A;  3EW5 A;  1GYT A;  5HOL A;  3V45 A;  2BFQ A;  5D8N A;  3SIJ A;  4KSI A;  3KQZ A;  4ZYQ A;  4JLL A;  3IJ3 A;  4ESS A;  4GVW A;  4GVV A;  5AIL A;  3GPQ A;  3KQX A;  3PEI A;  3EJG A;  3JZT A;  2FG1 A;  3KZW A;  5HIH A;  4J5S A;  4ETJ A;  3GPO A;  4IQY A;  3T8W A;  4ZY0 A;  1LAP A;  3SIG A;  2EWB A;  1LAM A;  4R6T A;  3GQO A;  4JCA A;  2EEE A;  2AFC A;  2DX6 A;  5CB3 A;  5DUS A;  4TU0 A;  4JVV A;  5FSX A;  1ZR5 A;  5CB5 A;  4GUA A;  3IIF A;  1ZR3 A;  4ABK A;  1BPM A;  3Q71 A;  1NJR A;  4R76 A;  5CMS A;  2FXK A;  1LAN A;  5E3B A;  2L8R A;  3Q6Z A;  3KR5 A;  3EWO A;  2XD7 A;  3H8F A;  4KYB A;  1VHU A;  2VRI A;  2LGR A;  4ZI6 A;  2FAV A;  2ACF A;  3EWR A;  4ZY1 A;  1YD9 A;  1SPV A;  1TY8 A;  4ZY2 A;  5FSU A;  4D86 A;  2BFR A;  1BLL E;  3ETI A;  4R7M A;  3GPG A;  4ABL A;  3EJF A;  4ZX9 A;  3H8G A;  5CBM A;  3EKE A;  3GQE A;  3EWP A;  4J4Z A;  5FSZ A;  4UML A;  1HJZ A; 
#chains in the Genus database with same CATH topology
 3KR4 A;  3JRU A;  2JZF A;  4ZX8 A;  3EWQ A;  3V2B A;  1LCP A;  4ETK A;  4X2T A;  1TXZ A;  4K0C A;  1BPN A;  4J5R A;  3H8E A;  5FSY A;  3IID A;  4J5Q A;  3SII A;  2J9A A;  4K3N A;  2KQV A;  2W2G A;  3SIH A;  3VFQ A;  5FSV A;  4JGK A;  2X47 A;  3EW5 A;  1GYT A;  5HOL A;  3V45 A;  2BFQ A;  5D8N A;  3SIJ A;  4KSI A;  3KQZ A;  2WCT A;  4ZYQ A;  4JLL A;  3IJ3 A;  4ESS A;  4GVW A;  4GVV A;  5AIL A;  2JZD A;  3GPQ A;  3KQX A;  3PEI A;  3EJG A;  3JZT A;  2FG1 A;  3KZW A;  5HIH A;  2JZE A;  4J5S A;  4ETJ A;  3GPO A;  4IQY A;  3T8W A;  4ZY0 A;  1LAP A;  3SIG A;  2EWB A;  1LAM A;  4R6T A;  3GQO A;  4JCA A;  2EEE A;  2AFC A;  2DX6 A;  5CB3 A;  5DUS A;  4TU0 A;  4JVV A;  5FSX A;  1ZR5 A;  5CB5 A;  4GUA A;  3IIF A;  1ZR3 A;  4ABK A;  1BPM A;  2RNK A;  3Q71 A;  1NJR A;  4R76 A;  5CMS A;  2FXK A;  1LAN A;  5E3B A;  2L8R A;  3Q6Z A;  3KR5 A;  3EWO A;  2XD7 A;  3H8F A;  4KYB A;  1VHU A;  2VRI A;  2LGR A;  4ZI6 A;  2FAV A;  2ACF A;  3EWR A;  4ZY1 A;  1YD9 A;  1SPV A;  1TY8 A;  4ZY2 A;  5FSU A;  4D86 A;  2BFR A;  1BLL E;  3ETI A;  4R7M A;  3GPG A;  4ABL A;  3EJF A;  4ZX9 A;  3H8G A;  5CBM A;  3EKE A;  3GQE A;  3EWP A;  4J4Z A;  5FSZ A;  4UML A;  1HJZ A; 
#chains in the Genus database with same CATH homology
 3KR4 A;  3JRU A;  4ZX8 A;  3V2B A;  3EWQ A;  4ETK A;  1LCP A;  4X2T A;  1TXZ A;  4K0C A;  1BPN A;  4J5R A;  3H8E A;  5FSY A;  3IID A;  4J5Q A;  3SII A;  2J9A A;  4K3N A;  3SIH A;  3VFQ A;  5FSV A;  4JGK A;  2X47 A;  3EW5 A;  1GYT A;  5HOL A;  3V45 A;  2BFQ A;  5D8N A;  3SIJ A;  4KSI A;  3KQZ A;  4ZYQ A;  4JLL A;  3IJ3 A;  4ESS A;  4GVW A;  4GVV A;  5AIL A;  3GPQ A;  3KQX A;  3PEI A;  3EJG A;  3JZT A;  2FG1 A;  3KZW A;  5HIH A;  4J5S A;  4ETJ A;  3GPO A;  4IQY A;  3T8W A;  4ZY0 A;  1LAP A;  3SIG A;  2EWB A;  1LAM A;  4R6T A;  3GQO A;  4JCA A;  2EEE A;  2AFC A;  2DX6 A;  5CB3 A;  5DUS A;  4TU0 A;  4JVV A;  5FSX A;  1ZR5 A;  5CB5 A;  4GUA A;  3IIF A;  1ZR3 A;  4ABK A;  1BPM A;  3Q71 A;  1NJR A;  4R76 A;  5CMS A;  2FXK A;  1LAN A;  5E3B A;  2L8R A;  3Q6Z A;  3KR5 A;  3EWO A;  2XD7 A;  3H8F A;  4KYB A;  1VHU A;  2VRI A;  2LGR A;  4ZI6 A;  2FAV A;  2ACF A;  3EWR A;  4ZY1 A;  1YD9 A;  1SPV A;  1TY8 A;  4ZY2 A;  5FSU A;  4D86 A;  2BFR A;  1BLL E;  3ETI A;  4R7M A;  3GPG A;  4ABL A;  3EJF A;  4ZX9 A;  3H8G A;  5CBM A;  3EKE A;  3GQE A;  3EWP A;  4J4Z A;  5FSZ A;  4UML A;  1HJZ A; 
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similar chains in the Genus database (?% sequence similarity)
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