5FSZA

Crystal structure of trypanosoma cruzi macrodomain
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
245
structure length
245
Chain Sequence
FVTYSTSEPAKLFGEAGRRSHFRARVLEATLSPLEKAIFDVPIEEWLTVDRSKFSGWRCAVPHPVTADELKPVDSSHDILRHIALYNGPVTDLQLDAIVNAANKTCLGGKGVDGAIHAAAGPLLVRECATFKGCDTGQCRLTKGYNLPARYVLHTVGPIGERPEELRSCYRSILSLAHRNRLRSIGFCCVSTGVYGYPLIPATRIAVDETIEYLKQHFSAFDLCCFACFKLEEYNAYTDCLRAWL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma cruzi
molecule keywords MACRODOMAIN
total genus 81
structure length 245
sequence length 245
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fszA00
1TY8A 4ABLA 3GQOA 4KYBA 3GQEA 2FG1A 3Q71A 4ZI6A 4X2TA 3H8FA 2X47A 3EWQA 5D8NA 4ZY0A 4J5QA 3EKEA 5CMSA 1YD9A 2J9AA 2VRIA 4JLLA 3EJFA 4ETKA 4K3NA 4ZX8A 3EW5A 2DX6A 3H8EA 4J4ZA 3KR4A 3VFQA 2FAVA 3V2BA 2LGRA 3V45A 1LAMA 4GUAA 3H8GA 5HOLA 3EWRA 3JZTA 1LCPA 3EJGA 4R76A 3Q6ZA 2FXKA 4KSIA 5DUSA 5CB3A 3GPOA 3KZWA 3PEIA 3IIFA 1LAPA 1TXZA 4J5SA 5FSUA 5FSZA 2BFRA 4K0CA 3SIIA 5FSXA 5FSYA 1GYTA 4D86A 1VHUA 4GVWA 4J5RA 4JCAA 4ESSA 4JGKA 1ZR3A 2EEEA 4ABKA 3IJ3A 2ACFA 1ZR5A 5CB5A 3SIHA 2BFQA 4ETJA 1BPMA 3T8WA 4UMLA 5E3BA 4ZX9A 3JRUA 3GPQA 2EWBA 3GPGA 4ZYQA 2XD7A 1BPNA 4JVVA 4IQYA 1LANA 3KQXA 2L8RA 3SIJA 1SPVA 3EWPA 4R6TA 1NJRA 2AFCA 1BLLE 3IIDA 5HIHA 4ZY1A 4R7MA 3ETIA 3EWOA 5FSVA 3KQZA 4TU0A 3SIGA 4ZY2A 5CBMA 5AILA 1HJZA 4GVVA 3KR5A
chains in the Genus database with same CATH superfamily
1TY8A 4ABLA 3GQOA 4KYBA 3GQEA 2FG1A 3Q71A 4ZI6A 4X2TA 3H8FA 2X47A 3EWQA 5D8NA 4ZY0A 2JZEA 4J5QA 3EKEA 5CMSA 1YD9A 2J9AA 2VRIA 4JLLA 3EJFA 4ETKA 2KQVA 4K3NA 4ZX8A 3EW5A 2DX6A 3H8EA 4J4ZA 3KR4A 3VFQA 2FAVA 3V2BA 2LGRA 3V45A 1LAMA 4GUAA 3H8GA 5HOLA 3EWRA 3JZTA 1LCPA 3EJGA 4R76A 3Q6ZA 2FXKA 4KSIA 5DUSA 5CB3A 3GPOA 3KZWA 3PEIA 3IIFA 1LAPA 1TXZA 4J5SA 5FSUA 5FSZA 2BFRA 4K0CA 3SIIA 5FSXA 5FSYA 1GYTA 4D86A 1VHUA 4GVWA 4J5RA 4JCAA 4ESSA 2W2GA 4JGKA 1ZR3A 2EEEA 4ABKA 3IJ3A 2ACFA 2WCTA 1ZR5A 5CB5A 3SIHA 2BFQA 4ETJA 1BPMA 3T8WA 4UMLA 5E3BA 4ZX9A 3JRUA 3GPQA 2EWBA 3GPGA 4ZYQA 2JZFA 2XD7A 1BPNA 4JVVA 4IQYA 1LANA 3KQXA 2L8RA 3SIJA 1SPVA 3EWPA 4R6TA 1NJRA 2AFCA 1BLLE 3IIDA 5HIHA 4ZY1A 2JZDA 4R7MA 3ETIA 3EWOA 5FSVA 3KQZA 4TU0A 3SIGA 4ZY2A 5CBMA 5AILA 1HJZA 4GVVA 3KR5A 2RNKA
chains in the Genus database with same CATH topology
1TY8A 4ABLA 3GQOA 4KYBA 3GQEA 2FG1A 3Q71A 4ZI6A 4X2TA 3H8FA 2X47A 3EWQA 5D8NA 4ZY0A 4J5QA 3EKEA 5CMSA 1YD9A 2J9AA 2VRIA 4JLLA 3EJFA 4ETKA 4K3NA 4ZX8A 3EW5A 2DX6A 3H8EA 4J4ZA 3KR4A 3VFQA 2FAVA 3V2BA 2LGRA 3V45A 1LAMA 4GUAA 3H8GA 5HOLA 3EWRA 3JZTA 1LCPA 3EJGA 4R76A 3Q6ZA 2FXKA 4KSIA 5DUSA 5CB3A 3GPOA 3KZWA 3PEIA 3IIFA 1LAPA 1TXZA 4J5SA 5FSUA 5FSZA 2BFRA 4K0CA 3SIIA 5FSXA 5FSYA 1GYTA 4D86A 1VHUA 4GVWA 4J5RA 4JCAA 4ESSA 4JGKA 1ZR3A 2EEEA 4ABKA 3IJ3A 2ACFA 1ZR5A 5CB5A 3SIHA 2BFQA 4ETJA 1BPMA 3T8WA 4UMLA 5E3BA 4ZX9A 3JRUA 3GPQA 2EWBA 3GPGA 4ZYQA 2XD7A 1BPNA 4JVVA 4IQYA 1LANA 3KQXA 2L8RA 3SIJA 1SPVA 3EWPA 4R6TA 1NJRA 2AFCA 1BLLE 3IIDA 5HIHA 4ZY1A 4R7MA 3ETIA 3EWOA 5FSVA 3KQZA 4TU0A 3SIGA 4ZY2A 5CBMA 5AILA 1HJZA 4GVVA 3KR5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TY8 A;  4ABL A;  3GQO A;  4KYB A;  3GQE A;  2FG1 A;  3Q71 A;  4ZI6 A;  4X2T A;  3H8F A;  2X47 A;  3EWQ A;  5D8N A;  4ZY0 A;  4J5Q A;  3EKE A;  5CMS A;  1YD9 A;  2J9A A;  2VRI A;  4JLL A;  3EJF A;  4ETK A;  4K3N A;  4ZX8 A;  3EW5 A;  2DX6 A;  3H8E A;  4J4Z A;  3KR4 A;  3VFQ A;  2FAV A;  3V2B A;  2LGR A;  3V45 A;  1LAM A;  4GUA A;  3H8G A;  5HOL A;  3EWR A;  3JZT A;  1LCP A;  3EJG A;  4R76 A;  3Q6Z A;  2FXK A;  4KSI A;  5DUS A;  5CB3 A;  3GPO A;  3KZW A;  3PEI A;  3IIF A;  1LAP A;  1TXZ A;  4J5S A;  5FSU A;  5FSZ A;  2BFR A;  4K0C A;  3SII A;  5FSX A;  5FSY A;  1GYT A;  4D86 A;  1VHU A;  4GVW A;  4J5R A;  4JCA A;  4ESS A;  4JGK A;  1ZR3 A;  2EEE A;  4ABK A;  3IJ3 A;  2ACF A;  1ZR5 A;  5CB5 A;  3SIH A;  2BFQ A;  4ETJ A;  1BPM A;  3T8W A;  4UML A;  5E3B A;  4ZX9 A;  3JRU A;  3GPQ A;  2EWB A;  3GPG A;  4ZYQ A;  2XD7 A;  1BPN A;  4JVV A;  4IQY A;  1LAN A;  3KQX A;  2L8R A;  3SIJ A;  1SPV A;  3EWP A;  4R6T A;  1NJR A;  2AFC A;  1BLL E;  3IID A;  5HIH A;  4ZY1 A;  4R7M A;  3ETI A;  3EWO A;  5FSV A;  3KQZ A;  4TU0 A;  3SIG A;  4ZY2 A;  5CBM A;  5AIL A;  1HJZ A;  4GVV A;  3KR5 A; 
#chains in the Genus database with same CATH topology
 1TY8 A;  4ABL A;  3GQO A;  4KYB A;  3GQE A;  2FG1 A;  3Q71 A;  4ZI6 A;  4X2T A;  3H8F A;  2X47 A;  3EWQ A;  5D8N A;  4ZY0 A;  2JZE A;  4J5Q A;  3EKE A;  5CMS A;  1YD9 A;  2J9A A;  2VRI A;  4JLL A;  3EJF A;  4ETK A;  2KQV A;  4K3N A;  4ZX8 A;  3EW5 A;  2DX6 A;  3H8E A;  4J4Z A;  3KR4 A;  3VFQ A;  2FAV A;  3V2B A;  2LGR A;  3V45 A;  1LAM A;  4GUA A;  3H8G A;  5HOL A;  3EWR A;  3JZT A;  1LCP A;  3EJG A;  4R76 A;  3Q6Z A;  2FXK A;  4KSI A;  5DUS A;  5CB3 A;  3GPO A;  3KZW A;  3PEI A;  3IIF A;  1LAP A;  1TXZ A;  4J5S A;  5FSU A;  5FSZ A;  2BFR A;  4K0C A;  3SII A;  5FSX A;  5FSY A;  1GYT A;  4D86 A;  1VHU A;  4GVW A;  4J5R A;  4JCA A;  4ESS A;  2W2G A;  4JGK A;  1ZR3 A;  2EEE A;  4ABK A;  3IJ3 A;  2ACF A;  2WCT A;  1ZR5 A;  5CB5 A;  3SIH A;  2BFQ A;  4ETJ A;  1BPM A;  3T8W A;  4UML A;  5E3B A;  4ZX9 A;  3JRU A;  3GPQ A;  2EWB A;  3GPG A;  4ZYQ A;  2JZF A;  2XD7 A;  1BPN A;  4JVV A;  4IQY A;  1LAN A;  3KQX A;  2L8R A;  3SIJ A;  1SPV A;  3EWP A;  4R6T A;  1NJR A;  2AFC A;  1BLL E;  3IID A;  5HIH A;  4ZY1 A;  2JZD A;  4R7M A;  3ETI A;  3EWO A;  5FSV A;  3KQZ A;  4TU0 A;  3SIG A;  4ZY2 A;  5CBM A;  5AIL A;  1HJZ A;  4GVV A;  3KR5 A;  2RNK A; 
#chains in the Genus database with same CATH homology
 1TY8 A;  4ABL A;  3GQO A;  4KYB A;  3GQE A;  2FG1 A;  3Q71 A;  4ZI6 A;  4X2T A;  3H8F A;  2X47 A;  3EWQ A;  5D8N A;  4ZY0 A;  4J5Q A;  3EKE A;  5CMS A;  1YD9 A;  2J9A A;  2VRI A;  4JLL A;  3EJF A;  4ETK A;  4K3N A;  4ZX8 A;  3EW5 A;  2DX6 A;  3H8E A;  4J4Z A;  3KR4 A;  3VFQ A;  2FAV A;  3V2B A;  2LGR A;  3V45 A;  1LAM A;  4GUA A;  3H8G A;  5HOL A;  3EWR A;  3JZT A;  1LCP A;  3EJG A;  4R76 A;  3Q6Z A;  2FXK A;  4KSI A;  5DUS A;  5CB3 A;  3GPO A;  3KZW A;  3PEI A;  3IIF A;  1LAP A;  1TXZ A;  4J5S A;  5FSU A;  5FSZ A;  2BFR A;  4K0C A;  3SII A;  5FSX A;  5FSY A;  1GYT A;  4D86 A;  1VHU A;  4GVW A;  4J5R A;  4JCA A;  4ESS A;  4JGK A;  1ZR3 A;  2EEE A;  4ABK A;  3IJ3 A;  2ACF A;  1ZR5 A;  5CB5 A;  3SIH A;  2BFQ A;  4ETJ A;  1BPM A;  3T8W A;  4UML A;  5E3B A;  4ZX9 A;  3JRU A;  3GPQ A;  2EWB A;  3GPG A;  4ZYQ A;  2XD7 A;  1BPN A;  4JVV A;  4IQY A;  1LAN A;  3KQX A;  2L8R A;  3SIJ A;  1SPV A;  3EWP A;  4R6T A;  1NJR A;  2AFC A;  1BLL E;  3IID A;  5HIH A;  4ZY1 A;  4R7M A;  3ETI A;  3EWO A;  5FSV A;  3KQZ A;  4TU0 A;  3SIG A;  4ZY2 A;  5CBM A;  5AIL A;  1HJZ A;  4GVV A;  3KR5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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