5HOLA

The crystal structure of the mers-cov macro domain with adp-ribose
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
167
structure length
167
Chain Sequence
MDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
pubmed doi rcsb
molecule tags Viral protein
source organism Middle east respiratory syndrome coronavirus
molecule keywords ORF1a
total genus 54
structure length 167
sequence length 167
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2016-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5holA00
4ABLA 3KQXA 3VFQA 2VRIA 3GQEA 5CMSA 4GUAA 4R6TA 4ZYQA 2FXKA 3KR5A 5AILA 3EJGA 3JRUA 2ACFA 4J4ZA 3GPOA 3EWRA 4J5QA 4GVVA 4ZI6A 1TXZA 4ETKA 1SPVA 4R76A 2EWBA 5DUSA 3SIHA 4ETJA 5D8NA 4ESSA 4KYBA 3SIJA 1VHUA 2EEEA 4X2TA 5E3BA 2L8RA 4JVVA 1BPNA 4R7MA 4ZY1A 3PEIA 3EKEA 4IQYA 3GQOA 1BPMA 3V2BA 4JCAA 4K3NA 1ZR5A 5FSUA 3H8EA 2FAVA 3EWQA 3KQZA 3SIIA 4ZX9A 5FSYA 3T8WA 5FSVA 3EWPA 3IJ3A 4J5RA 3JZTA 3GPGA 1LAPA 4J5SA 2BFQA 4UMLA 4JGKA 4ZY0A 3SIGA 1GYTA 2XD7A 2FG1A 5CB5A 3IIFA 3Q6ZA 5HOLA 4D86A 3EW5A 3Q71A 3EJFA 3IIDA 1LCPA 3KR4A 3H8GA 4JLLA 1NJRA 1YD9A 2DX6A 5FSXA 3KZWA 4ZX8A 4ZY2A 3V45A 4GVWA 5HIHA 3ETIA 3H8FA 1TY8A 2BFRA 4K0CA 1LAMA 2J9AA 4TU0A 1BLLE 4KSIA 1ZR3A 4ABKA 5FSZA 1LANA 1HJZA 3EWOA 5CB3A 2X47A 2AFCA 3GPQA 5CBMA 2LGRA
chains in the Genus database with same CATH superfamily
4ABLA 3KQXA 3VFQA 2VRIA 3GQEA 5CMSA 2WCTA 4GUAA 4R6TA 4ZYQA 2FXKA 3KR5A 5AILA 3EJGA 3JRUA 2ACFA 4J4ZA 3GPOA 3EWRA 4J5QA 4GVVA 4ZI6A 1TXZA 4ETKA 1SPVA 4R76A 2EWBA 5DUSA 3SIHA 4ETJA 5D8NA 4ESSA 4KYBA 3SIJA 2JZFA 1VHUA 2EEEA 4X2TA 5E3BA 2L8RA 4JVVA 1BPNA 4R7MA 4ZY1A 3PEIA 3EKEA 4IQYA 3GQOA 1BPMA 3V2BA 4JCAA 4K3NA 1ZR5A 5FSUA 3H8EA 2FAVA 3EWQA 3KQZA 3SIIA 4ZX9A 5FSYA 3T8WA 5FSVA 3EWPA 3IJ3A 4J5RA 2KQVA 3JZTA 3GPGA 1LAPA 4J5SA 2BFQA 4UMLA 4JGKA 4ZY0A 3SIGA 1GYTA 2XD7A 2FG1A 5CB5A 3IIFA 3Q6ZA 5HOLA 4D86A 3EW5A 3Q71A 3EJFA 3IIDA 1LCPA 3KR4A 3H8GA 4JLLA 2RNKA 1NJRA 2W2GA 1YD9A 2DX6A 5FSXA 3KZWA 4ZX8A 4ZY2A 3V45A 4GVWA 5HIHA 3ETIA 3H8FA 1TY8A 2BFRA 4K0CA 1LAMA 2J9AA 4TU0A 1BLLE 2JZDA 4KSIA 1ZR3A 4ABKA 5FSZA 1LANA 1HJZA 3EWOA 5CB3A 2X47A 2AFCA 3GPQA 2JZEA 5CBMA 2LGRA
chains in the Genus database with same CATH topology
4ABLA 3KQXA 3VFQA 2VRIA 3GQEA 5CMSA 4GUAA 4R6TA 4ZYQA 2FXKA 3KR5A 5AILA 3EJGA 3JRUA 2ACFA 4J4ZA 3GPOA 3EWRA 4J5QA 4GVVA 4ZI6A 1TXZA 4ETKA 1SPVA 4R76A 2EWBA 5DUSA 3SIHA 4ETJA 5D8NA 4ESSA 4KYBA 3SIJA 1VHUA 2EEEA 4X2TA 5E3BA 2L8RA 4JVVA 1BPNA 4R7MA 4ZY1A 3PEIA 3EKEA 4IQYA 3GQOA 1BPMA 3V2BA 4JCAA 4K3NA 1ZR5A 5FSUA 3H8EA 2FAVA 3EWQA 3KQZA 3SIIA 4ZX9A 5FSYA 3T8WA 5FSVA 3EWPA 3IJ3A 4J5RA 3JZTA 3GPGA 1LAPA 4J5SA 2BFQA 4UMLA 4JGKA 4ZY0A 3SIGA 1GYTA 2XD7A 2FG1A 5CB5A 3IIFA 3Q6ZA 5HOLA 4D86A 3EW5A 3Q71A 3EJFA 3IIDA 1LCPA 3KR4A 3H8GA 4JLLA 1NJRA 1YD9A 2DX6A 5FSXA 3KZWA 4ZX8A 4ZY2A 3V45A 4GVWA 5HIHA 3ETIA 3H8FA 1TY8A 2BFRA 4K0CA 1LAMA 2J9AA 4TU0A 1BLLE 4KSIA 1ZR3A 4ABKA 5FSZA 1LANA 1HJZA 3EWOA 5CB3A 2X47A 2AFCA 3GPQA 5CBMA 2LGRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ABL A;  3KQX A;  3VFQ A;  2VRI A;  3GQE A;  5CMS A;  4GUA A;  4R6T A;  4ZYQ A;  2FXK A;  3KR5 A;  5AIL A;  3EJG A;  3JRU A;  2ACF A;  4J4Z A;  3GPO A;  3EWR A;  4J5Q A;  4GVV A;  4ZI6 A;  1TXZ A;  4ETK A;  1SPV A;  4R76 A;  2EWB A;  5DUS A;  3SIH A;  4ETJ A;  5D8N A;  4ESS A;  4KYB A;  3SIJ A;  1VHU A;  2EEE A;  4X2T A;  5E3B A;  2L8R A;  4JVV A;  1BPN A;  4R7M A;  4ZY1 A;  3PEI A;  3EKE A;  4IQY A;  3GQO A;  1BPM A;  3V2B A;  4JCA A;  4K3N A;  1ZR5 A;  5FSU A;  3H8E A;  2FAV A;  3EWQ A;  3KQZ A;  3SII A;  4ZX9 A;  5FSY A;  3T8W A;  5FSV A;  3EWP A;  3IJ3 A;  4J5R A;  3JZT A;  3GPG A;  1LAP A;  4J5S A;  2BFQ A;  4UML A;  4JGK A;  4ZY0 A;  3SIG A;  1GYT A;  2XD7 A;  2FG1 A;  5CB5 A;  3IIF A;  3Q6Z A;  5HOL A;  4D86 A;  3EW5 A;  3Q71 A;  3EJF A;  3IID A;  1LCP A;  3KR4 A;  3H8G A;  4JLL A;  1NJR A;  1YD9 A;  2DX6 A;  5FSX A;  3KZW A;  4ZX8 A;  4ZY2 A;  3V45 A;  4GVW A;  5HIH A;  3ETI A;  3H8F A;  1TY8 A;  2BFR A;  4K0C A;  1LAM A;  2J9A A;  4TU0 A;  1BLL E;  4KSI A;  1ZR3 A;  4ABK A;  5FSZ A;  1LAN A;  1HJZ A;  3EWO A;  5CB3 A;  2X47 A;  2AFC A;  3GPQ A;  5CBM A;  2LGR A; 
#chains in the Genus database with same CATH topology
 4ABL A;  3KQX A;  3VFQ A;  2VRI A;  3GQE A;  5CMS A;  2WCT A;  4GUA A;  4R6T A;  4ZYQ A;  2FXK A;  3KR5 A;  5AIL A;  3EJG A;  3JRU A;  2ACF A;  4J4Z A;  3GPO A;  3EWR A;  4J5Q A;  4GVV A;  4ZI6 A;  1TXZ A;  4ETK A;  1SPV A;  4R76 A;  2EWB A;  5DUS A;  3SIH A;  4ETJ A;  5D8N A;  4ESS A;  4KYB A;  3SIJ A;  2JZF A;  1VHU A;  2EEE A;  4X2T A;  5E3B A;  2L8R A;  4JVV A;  1BPN A;  4R7M A;  4ZY1 A;  3PEI A;  3EKE A;  4IQY A;  3GQO A;  1BPM A;  3V2B A;  4JCA A;  4K3N A;  1ZR5 A;  5FSU A;  3H8E A;  2FAV A;  3EWQ A;  3KQZ A;  3SII A;  4ZX9 A;  5FSY A;  3T8W A;  5FSV A;  3EWP A;  3IJ3 A;  4J5R A;  2KQV A;  3JZT A;  3GPG A;  1LAP A;  4J5S A;  2BFQ A;  4UML A;  4JGK A;  4ZY0 A;  3SIG A;  1GYT A;  2XD7 A;  2FG1 A;  5CB5 A;  3IIF A;  3Q6Z A;  5HOL A;  4D86 A;  3EW5 A;  3Q71 A;  3EJF A;  3IID A;  1LCP A;  3KR4 A;  3H8G A;  4JLL A;  2RNK A;  1NJR A;  2W2G A;  1YD9 A;  2DX6 A;  5FSX A;  3KZW A;  4ZX8 A;  4ZY2 A;  3V45 A;  4GVW A;  5HIH A;  3ETI A;  3H8F A;  1TY8 A;  2BFR A;  4K0C A;  1LAM A;  2J9A A;  4TU0 A;  1BLL E;  2JZD A;  4KSI A;  1ZR3 A;  4ABK A;  5FSZ A;  1LAN A;  1HJZ A;  3EWO A;  5CB3 A;  2X47 A;  2AFC A;  3GPQ A;  2JZE A;  5CBM A;  2LGR A; 
#chains in the Genus database with same CATH homology
 4ABL A;  3KQX A;  3VFQ A;  2VRI A;  3GQE A;  5CMS A;  4GUA A;  4R6T A;  4ZYQ A;  2FXK A;  3KR5 A;  5AIL A;  3EJG A;  3JRU A;  2ACF A;  4J4Z A;  3GPO A;  3EWR A;  4J5Q A;  4GVV A;  4ZI6 A;  1TXZ A;  4ETK A;  1SPV A;  4R76 A;  2EWB A;  5DUS A;  3SIH A;  4ETJ A;  5D8N A;  4ESS A;  4KYB A;  3SIJ A;  1VHU A;  2EEE A;  4X2T A;  5E3B A;  2L8R A;  4JVV A;  1BPN A;  4R7M A;  4ZY1 A;  3PEI A;  3EKE A;  4IQY A;  3GQO A;  1BPM A;  3V2B A;  4JCA A;  4K3N A;  1ZR5 A;  5FSU A;  3H8E A;  2FAV A;  3EWQ A;  3KQZ A;  3SII A;  4ZX9 A;  5FSY A;  3T8W A;  5FSV A;  3EWP A;  3IJ3 A;  4J5R A;  3JZT A;  3GPG A;  1LAP A;  4J5S A;  2BFQ A;  4UML A;  4JGK A;  4ZY0 A;  3SIG A;  1GYT A;  2XD7 A;  2FG1 A;  5CB5 A;  3IIF A;  3Q6Z A;  5HOL A;  4D86 A;  3EW5 A;  3Q71 A;  3EJF A;  3IID A;  1LCP A;  3KR4 A;  3H8G A;  4JLL A;  1NJR A;  1YD9 A;  2DX6 A;  5FSX A;  3KZW A;  4ZX8 A;  4ZY2 A;  3V45 A;  4GVW A;  5HIH A;  3ETI A;  3H8F A;  1TY8 A;  2BFR A;  4K0C A;  1LAM A;  2J9A A;  4TU0 A;  1BLL E;  4KSI A;  1ZR3 A;  4ABK A;  5FSZ A;  1LAN A;  1HJZ A;  3EWO A;  5CB3 A;  2X47 A;  2AFC A;  3GPQ A;  5CBM A;  2LGR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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