5HOLA

The crystal structure of the mers-cov macro domain with adp-ribose
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
167
structure length
167
Chain Sequence
MDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
pubmed doi rcsb
molecule tags Viral protein
source organism Middle east respiratory syndrome coronavirus
molecule keywords ORF1a
total genus 54
structure length 167
sequence length 167
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2016-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5holA00
4ZX8A 3IIDA 2DX6A 3KR4A 1LCPA 4GVVA 2AFCA 3Q6ZA 5CB5A 1TY8A 1BLLE 5AILA 4ZY0A 3EWOA 3EWQA 2J9AA 2LGRA 3GQEA 4UMLA 4ZYQA 2BFQA 4ZI6A 5CBMA 3KZWA 5CB3A 1BPMA 4X2TA 1SPVA 3PEIA 5FSUA 2VRIA 1LANA 4GVWA 3EKEA 4ABLA 4TU0A 3GPGA 5E3BA 2XD7A 3KR5A 1ZR5A 4JLLA 4ETJA 4D86A 3IIFA 3JZTA 4R6TA 4K0CA 1VHUA 3EW5A 4ZY2A 4ESSA 4GUAA 2FXKA 4ZY1A 4J4ZA 4ZX9A 4JCAA 3SIJA 5D8NA 2EEEA 3SIIA 3GPOA 2EWBA 2FAVA 3JRUA 2BFRA 4J5SA 3ETIA 3T8WA 3VFQA 3KQZA 1BPNA 1GYTA 5CMSA 3SIGA 4R76A 5FSVA 3V45A 5FSZA 4KSIA 3GPQA 3H8FA 3EJFA 3SIHA 4JVVA 3EJGA 5FSXA 3EWRA 4J5QA 2ACFA 5DUSA 1TXZA 1LAPA 1LAMA 3V2BA 3EWPA 4KYBA 4ETKA 1YD9A 1HJZA 5HOLA 4JGKA 1NJRA 4K3NA 4ABKA 3H8GA 1ZR3A 3Q71A 4IQYA 2L8RA 3GQOA 5FSYA 4J5RA 2FG1A 4R7MA 5HIHA 3IJ3A 3H8EA 2X47A 3KQXA
chains in the Genus database with same CATH superfamily
4ZX8A 3IIDA 2DX6A 3KR4A 1LCPA 4GVVA 2AFCA 3Q6ZA 5CB5A 1TY8A 1BLLE 5AILA 4ZY0A 3EWOA 3EWQA 2J9AA 2LGRA 3GQEA 4UMLA 4ZYQA 2BFQA 4ZI6A 5CBMA 3KZWA 5CB3A 1BPMA 4X2TA 1SPVA 2JZFA 3PEIA 5FSUA 2VRIA 1LANA 4GVWA 2WCTA 3EKEA 4ABLA 4TU0A 3GPGA 5E3BA 2XD7A 3KR5A 1ZR5A 4JLLA 4ETJA 4D86A 3IIFA 3JZTA 4R6TA 4K0CA 1VHUA 3EW5A 4ZY2A 4ESSA 4GUAA 2FXKA 4ZY1A 4J4ZA 4ZX9A 4JCAA 3SIJA 5D8NA 2EEEA 3SIIA 3GPOA 2EWBA 2FAVA 3JRUA 2BFRA 4J5SA 3ETIA 3T8WA 3VFQA 3KQZA 1BPNA 1GYTA 5CMSA 3SIGA 4R76A 5FSVA 3V45A 5FSZA 4KSIA 3GPQA 2KQVA 3H8FA 3EJFA 3SIHA 4JVVA 3EJGA 5FSXA 3EWRA 4J5QA 2ACFA 2RNKA 5DUSA 1TXZA 1LAPA 1LAMA 3V2BA 3EWPA 4KYBA 4ETKA 1YD9A 1HJZA 5HOLA 4JGKA 1NJRA 4K3NA 4ABKA 3H8GA 1ZR3A 3Q71A 4IQYA 2L8RA 3GQOA 5FSYA 2W2GA 4J5RA 2JZEA 2FG1A 4R7MA 2JZDA 5HIHA 3IJ3A 3H8EA 2X47A 3KQXA
chains in the Genus database with same CATH topology
4ZX8A 3IIDA 2DX6A 3KR4A 1LCPA 4GVVA 2AFCA 3Q6ZA 5CB5A 1TY8A 1BLLE 5AILA 4ZY0A 3EWOA 3EWQA 2J9AA 2LGRA 3GQEA 4UMLA 4ZYQA 2BFQA 4ZI6A 5CBMA 3KZWA 5CB3A 1BPMA 4X2TA 1SPVA 3PEIA 5FSUA 2VRIA 1LANA 4GVWA 3EKEA 4ABLA 4TU0A 3GPGA 5E3BA 2XD7A 3KR5A 1ZR5A 4JLLA 4ETJA 4D86A 3IIFA 3JZTA 4R6TA 4K0CA 1VHUA 3EW5A 4ZY2A 4ESSA 4GUAA 2FXKA 4ZY1A 4J4ZA 4ZX9A 4JCAA 3SIJA 5D8NA 2EEEA 3SIIA 3GPOA 2EWBA 2FAVA 3JRUA 2BFRA 4J5SA 3ETIA 3T8WA 3VFQA 3KQZA 1BPNA 1GYTA 5CMSA 3SIGA 4R76A 5FSVA 3V45A 5FSZA 4KSIA 3GPQA 3H8FA 3EJFA 3SIHA 4JVVA 3EJGA 5FSXA 3EWRA 4J5QA 2ACFA 5DUSA 1TXZA 1LAPA 1LAMA 3V2BA 3EWPA 4KYBA 4ETKA 1YD9A 1HJZA 5HOLA 4JGKA 1NJRA 4K3NA 4ABKA 3H8GA 1ZR3A 3Q71A 4IQYA 2L8RA 3GQOA 5FSYA 4J5RA 2FG1A 4R7MA 5HIHA 3IJ3A 3H8EA 2X47A 3KQXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZX8 A;  3IID A;  2DX6 A;  3KR4 A;  1LCP A;  4GVV A;  2AFC A;  3Q6Z A;  5CB5 A;  1TY8 A;  1BLL E;  5AIL A;  4ZY0 A;  3EWO A;  3EWQ A;  2J9A A;  2LGR A;  3GQE A;  4UML A;  4ZYQ A;  2BFQ A;  4ZI6 A;  5CBM A;  3KZW A;  5CB3 A;  1BPM A;  4X2T A;  1SPV A;  3PEI A;  5FSU A;  2VRI A;  1LAN A;  4GVW A;  3EKE A;  4ABL A;  4TU0 A;  3GPG A;  5E3B A;  2XD7 A;  3KR5 A;  1ZR5 A;  4JLL A;  4ETJ A;  4D86 A;  3IIF A;  3JZT A;  4R6T A;  4K0C A;  1VHU A;  3EW5 A;  4ZY2 A;  4ESS A;  4GUA A;  2FXK A;  4ZY1 A;  4J4Z A;  4ZX9 A;  4JCA A;  3SIJ A;  5D8N A;  2EEE A;  3SII A;  3GPO A;  2EWB A;  2FAV A;  3JRU A;  2BFR A;  4J5S A;  3ETI A;  3T8W A;  3VFQ A;  3KQZ A;  1BPN A;  1GYT A;  5CMS A;  3SIG A;  4R76 A;  5FSV A;  3V45 A;  5FSZ A;  4KSI A;  3GPQ A;  3H8F A;  3EJF A;  3SIH A;  4JVV A;  3EJG A;  5FSX A;  3EWR A;  4J5Q A;  2ACF A;  5DUS A;  1TXZ A;  1LAP A;  1LAM A;  3V2B A;  3EWP A;  4KYB A;  4ETK A;  1YD9 A;  1HJZ A;  5HOL A;  4JGK A;  1NJR A;  4K3N A;  4ABK A;  3H8G A;  1ZR3 A;  3Q71 A;  4IQY A;  2L8R A;  3GQO A;  5FSY A;  4J5R A;  2FG1 A;  4R7M A;  5HIH A;  3IJ3 A;  3H8E A;  2X47 A;  3KQX A; 
#chains in the Genus database with same CATH topology
 4ZX8 A;  3IID A;  2DX6 A;  3KR4 A;  1LCP A;  4GVV A;  2AFC A;  3Q6Z A;  5CB5 A;  1TY8 A;  1BLL E;  5AIL A;  4ZY0 A;  3EWO A;  3EWQ A;  2J9A A;  2LGR A;  3GQE A;  4UML A;  4ZYQ A;  2BFQ A;  4ZI6 A;  5CBM A;  3KZW A;  5CB3 A;  1BPM A;  4X2T A;  1SPV A;  2JZF A;  3PEI A;  5FSU A;  2VRI A;  1LAN A;  4GVW A;  2WCT A;  3EKE A;  4ABL A;  4TU0 A;  3GPG A;  5E3B A;  2XD7 A;  3KR5 A;  1ZR5 A;  4JLL A;  4ETJ A;  4D86 A;  3IIF A;  3JZT A;  4R6T A;  4K0C A;  1VHU A;  3EW5 A;  4ZY2 A;  4ESS A;  4GUA A;  2FXK A;  4ZY1 A;  4J4Z A;  4ZX9 A;  4JCA A;  3SIJ A;  5D8N A;  2EEE A;  3SII A;  3GPO A;  2EWB A;  2FAV A;  3JRU A;  2BFR A;  4J5S A;  3ETI A;  3T8W A;  3VFQ A;  3KQZ A;  1BPN A;  1GYT A;  5CMS A;  3SIG A;  4R76 A;  5FSV A;  3V45 A;  5FSZ A;  4KSI A;  3GPQ A;  2KQV A;  3H8F A;  3EJF A;  3SIH A;  4JVV A;  3EJG A;  5FSX A;  3EWR A;  4J5Q A;  2ACF A;  2RNK A;  5DUS A;  1TXZ A;  1LAP A;  1LAM A;  3V2B A;  3EWP A;  4KYB A;  4ETK A;  1YD9 A;  1HJZ A;  5HOL A;  4JGK A;  1NJR A;  4K3N A;  4ABK A;  3H8G A;  1ZR3 A;  3Q71 A;  4IQY A;  2L8R A;  3GQO A;  5FSY A;  2W2G A;  4J5R A;  2JZE A;  2FG1 A;  4R7M A;  2JZD A;  5HIH A;  3IJ3 A;  3H8E A;  2X47 A;  3KQX A; 
#chains in the Genus database with same CATH homology
 4ZX8 A;  3IID A;  2DX6 A;  3KR4 A;  1LCP A;  4GVV A;  2AFC A;  3Q6Z A;  5CB5 A;  1TY8 A;  1BLL E;  5AIL A;  4ZY0 A;  3EWO A;  3EWQ A;  2J9A A;  2LGR A;  3GQE A;  4UML A;  4ZYQ A;  2BFQ A;  4ZI6 A;  5CBM A;  3KZW A;  5CB3 A;  1BPM A;  4X2T A;  1SPV A;  3PEI A;  5FSU A;  2VRI A;  1LAN A;  4GVW A;  3EKE A;  4ABL A;  4TU0 A;  3GPG A;  5E3B A;  2XD7 A;  3KR5 A;  1ZR5 A;  4JLL A;  4ETJ A;  4D86 A;  3IIF A;  3JZT A;  4R6T A;  4K0C A;  1VHU A;  3EW5 A;  4ZY2 A;  4ESS A;  4GUA A;  2FXK A;  4ZY1 A;  4J4Z A;  4ZX9 A;  4JCA A;  3SIJ A;  5D8N A;  2EEE A;  3SII A;  3GPO A;  2EWB A;  2FAV A;  3JRU A;  2BFR A;  4J5S A;  3ETI A;  3T8W A;  3VFQ A;  3KQZ A;  1BPN A;  1GYT A;  5CMS A;  3SIG A;  4R76 A;  5FSV A;  3V45 A;  5FSZ A;  4KSI A;  3GPQ A;  3H8F A;  3EJF A;  3SIH A;  4JVV A;  3EJG A;  5FSX A;  3EWR A;  4J5Q A;  2ACF A;  5DUS A;  1TXZ A;  1LAP A;  1LAM A;  3V2B A;  3EWP A;  4KYB A;  4ETK A;  1YD9 A;  1HJZ A;  5HOL A;  4JGK A;  1NJR A;  4K3N A;  4ABK A;  3H8G A;  1ZR3 A;  3Q71 A;  4IQY A;  2L8R A;  3GQO A;  5FSY A;  4J5R A;  2FG1 A;  4R7M A;  5HIH A;  3IJ3 A;  3H8E A;  2X47 A;  3KQX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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