4MCBA

H.influenzae trmd in complex with n-(4-{[(1h-imidazol-2-ylmethyl)amino]methyl}benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
Knots found
sequence length
219
structure length
205
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGLLDCPHYTRPEVLEGLTVPPVLMSHHEEIRKWRLKQSLQRTWLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 50
structure length 205
sequence length 219
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mcbA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mcbA01
3KW2A 4J3CA 1UALA 1ZJRA 4YQGA 2Z0YA 3IEFA 1UAJA 4YQ8A 4YQPA 4YQ5A 1NXZA 4YQ7A 4YQ6A 2EGWA 4CNGA 4KDZA 5GMBA 5CO4A 4YQKA 4IG6A 4YQAA 4JAKA 4YQNA 1VH0A 3DCMX 3BBDA 4YQQA 3BBEA 4YPYA 4YPXA 4YQ2A 4YQRA 3NK6A 5FAIA 5GM8A 4RG1A 4YQ4A 4YQ3A 4XBOA 3KNUA 4YQDA 1IPAA 3N4JA 3AXZA 4YVJA 3ILKA 3OIIA 1UAMA 4X3MA 4YQBA 4E8BA 4YVGA 1O6DA 1TO0A 1V6ZA 2EGVA 4YQLA 2QWVA 4YQCA 3OIJA 4X3LA 4L69A 4MCDA 2YY8A 2V3KA 3O7BA 1VHYA 4YQTA 1OY5A 4H3ZA 1MXIA 3GYQA 3N4KA 4YQIA 4YPWA 4YQ0A 4MCBA 4KGNA 3BBHA 1P9PA 1Z85A 2V3JA 5GMCA 4CNEA 3IC6A 2HA8A 5D9FA 3QUVA 3AI9X 4YQOA 1NS5A 4YQSA 4YVIA 4FAKA 3ONPA 1X7OA 2QMMA 4CNFA 1V2XA 4YQ9A 1J85A 3L8UA 4YVHA 1UAKA 4CNDA 4YQJA 1VHKA 3KY7A 4JALA 3OINA 4MCCA 1GZ0A 4YPZA 3AIAA 4PZKA 3E5YA 4YQ1A 2I6DA 1K3RA 3KTYA 4H3YA 3NK7A 2CX8A 1X7PA 4YVKA 2O3AA
chains in the Genus database with same CATH superfamily
3KW2A 4J3CA 1UALA 1ZJRA 4YQGA 2Z0YA 3IEFA 1UAJA 4YQ8A 4YQPA 4YQ5A 1NXZA 4YQ7A 4YQ6A 2EGWA 1WRTR 4CNGA 4KDZA 5GMBA 5CO4A 4YQKA 4IG6A 4YQAA 4JAKA 4YQNA 1VH0A 3DCMX 3BBDA 3G1CA 4YQQA 3SSWN 3KORA 3BBEA 3SSXN 1ZT9A 4YPYA 4YPXA 4YQ2A 4YQRA 3NK6A 5FAIA 5GM8A 4RG1A 4YQ4A 4YQ3A 4XBOA 1CO0A 3KNUA 4YQDA 1IPAA 3N4JA 3AXZA 4YVJA 3ILKA 3OIIA 1UAMA 4X3MA 4YQBA 4E8BA 1TRRA 4YVGA 4FMWA 1O6DA 1TO0A 1V6ZA 2EGVA 4YQLA 2QWVA 4YQCA 3OIJA 4X3LA 4L69A 4MCDA 2YY8A 2V3KA 1WRPR 3O7BA 1VHYA 4JWJA 4YQTA 3FRWA 1OY5A 4H3ZA 1MXIA 3GYQA 3N4KA 4YQIA 4YPWA 4YQ0A 4MCBA 4KGNA 3BBHA 1P9PA 1Z85A 2V3JA 4JWFA 5GMCA 4CNEA 3IC6A 2HA8A 5D9FA 3QUVA 3AI9X 4YQOA 1NS5A 4YQSA 1RCSA 4YVIA 4FAKA 3ONPA 2OZ9R 1X7OA 2QMMA 2XDIA 4CNFA 1V2XA 4YQ9A 1J85A 3L8UA 4YVHA 1UAKA 4JWGA 4CNDA 4YQJA 1VHKA 3KY7A 1WRSR 4JALA 3OINA 4MCCA 1GZ0A 4JWHA 4YPZA 1MI7R 1TROA 3AIAA 4PZKA 3E5YA 4YQ1A 2I6DA 1K3RA 3KTYA 4H3YA 3NK7A 3WRPA 2CX8A 1X7PA 4YVKA 1JHGA 2O3AA
chains in the Genus database with same CATH topology
3KW2A 4J3CA 1UALA 1ZJRA 4YQGA 2Z0YA 3IEFA 1UAJA 4YQ8A 4YQPA 4YQ5A 1NXZA 4YQ7A 4YQ6A 2EGWA 4CNGA 4KDZA 5GMBA 5CO4A 4YQKA 4IG6A 4YQAA 4JAKA 4YQNA 1VH0A 3DCMX 3BBDA 4YQQA 3BBEA 4YPYA 4YPXA 4YQ2A 4YQRA 3NK6A 5FAIA 5GM8A 4RG1A 4YQ4A 4YQ3A 4XBOA 3KNUA 4YQDA 1IPAA 3N4JA 3AXZA 4YVJA 3ILKA 3OIIA 1UAMA 4X3MA 4YQBA 4E8BA 4YVGA 4FMWA 1O6DA 1TO0A 1V6ZA 2EGVA 4YQLA 2QWVA 4YQCA 3OIJA 4X3LA 4L69A 4MCDA 2YY8A 2V3KA 3O7BA 1VHYA 4JWJA 4YQTA 1OY5A 4H3ZA 1MXIA 3GYQA 3N4KA 4YQIA 4YPWA 4YQ0A 4MCBA 4KGNA 3BBHA 1P9PA 1Z85A 2V3JA 4JWFA 5GMCA 4CNEA 3IC6A 2HA8A 5D9FA 3QUVA 3AI9X 4YQOA 1NS5A 4YQSA 4YVIA 4FAKA 3ONPA 1X7OA 2QMMA 4CNFA 1V2XA 4YQ9A 1J85A 3L8UA 4YVHA 1UAKA 4JWGA 4CNDA 4YQJA 1VHKA 3KY7A 4JALA 3OINA 4MCCA 1GZ0A 4JWHA 4YPZA 3AIAA 4PZKA 3E5YA 4YQ1A 2I6DA 1K3RA 3KTYA 4H3YA 3NK7A 2CX8A 1X7PA 4YVKA 2O3AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KW2 A;  4J3C A;  1UAL A;  1ZJR A;  4YQG A;  2Z0Y A;  3IEF A;  1UAJ A;  4YQ8 A;  4YQP A;  4YQ5 A;  1NXZ A;  4YQ7 A;  4YQ6 A;  2EGW A;  4CNG A;  4KDZ A;  5GMB A;  5CO4 A;  4YQK A;  4IG6 A;  4YQA A;  4JAK A;  4YQN A;  1VH0 A;  3DCM X;  3BBD A;  4YQQ A;  3BBE A;  4YPY A;  4YPX A;  4YQ2 A;  4YQR A;  3NK6 A;  5FAI A;  5GM8 A;  4RG1 A;  4YQ4 A;  4YQ3 A;  4XBO A;  3KNU A;  4YQD A;  1IPA A;  3N4J A;  3AXZ A;  4YVJ A;  3ILK A;  3OII A;  1UAM A;  4X3M A;  4YQB A;  4E8B A;  4YVG A;  1O6D A;  1TO0 A;  1V6Z A;  2EGV A;  4YQL A;  2QWV A;  4YQC A;  3OIJ A;  4X3L A;  4L69 A;  4MCD A;  2YY8 A;  2V3K A;  3O7B A;  1VHY A;  4YQT A;  1OY5 A;  4H3Z A;  1MXI A;  3GYQ A;  3N4K A;  4YQI A;  4YPW A;  4YQ0 A;  4MCB A;  4KGN A;  3BBH A;  1P9P A;  1Z85 A;  2V3J A;  5GMC A;  4CNE A;  3IC6 A;  2HA8 A;  5D9F A;  3QUV A;  3AI9 X;  4YQO A;  1NS5 A;  4YQS A;  4YVI A;  4FAK A;  3ONP A;  1X7O A;  2QMM A;  4CNF A;  1V2X A;  4YQ9 A;  1J85 A;  3L8U A;  4YVH A;  1UAK A;  4CND A;  4YQJ A;  1VHK A;  3KY7 A;  4JAL A;  3OIN A;  4MCC A;  1GZ0 A;  4YPZ A;  3AIA A;  4PZK A;  3E5Y A;  4YQ1 A;  2I6D A;  1K3R A;  3KTY A;  4H3Y A;  3NK7 A;  2CX8 A;  1X7P A;  4YVK A;  2O3A A; 
#chains in the Genus database with same CATH topology
 3KW2 A;  4J3C A;  1UAL A;  1ZJR A;  4YQG A;  2Z0Y A;  3IEF A;  1UAJ A;  4YQ8 A;  4YQP A;  4YQ5 A;  1NXZ A;  4YQ7 A;  4YQ6 A;  2EGW A;  1WRT R;  4CNG A;  4KDZ A;  5GMB A;  5CO4 A;  4YQK A;  4IG6 A;  4YQA A;  4JAK A;  4YQN A;  1VH0 A;  3DCM X;  3BBD A;  3G1C A;  4YQQ A;  3SSW N;  3KOR A;  3BBE A;  3SSX N;  1ZT9 A;  4YPY A;  4YPX A;  4YQ2 A;  4YQR A;  3NK6 A;  5FAI A;  5GM8 A;  4RG1 A;  4YQ4 A;  4YQ3 A;  4XBO A;  1CO0 A;  3KNU A;  4YQD A;  1IPA A;  3N4J A;  3AXZ A;  4YVJ A;  3ILK A;  3OII A;  1UAM A;  4X3M A;  4YQB A;  4E8B A;  1TRR A;  4YVG A;  4FMW A;  1O6D A;  1TO0 A;  1V6Z A;  2EGV A;  4YQL A;  2QWV A;  4YQC A;  3OIJ A;  4X3L A;  4L69 A;  4MCD A;  2YY8 A;  2V3K A;  1WRP R;  3O7B A;  1VHY A;  4JWJ A;  4YQT A;  3FRW A;  1OY5 A;  4H3Z A;  1MXI A;  3GYQ A;  3N4K A;  4YQI A;  4YPW A;  4YQ0 A;  4MCB A;  4KGN A;  3BBH A;  1P9P A;  1Z85 A;  2V3J A;  4JWF A;  5GMC A;  4CNE A;  3IC6 A;  2HA8 A;  5D9F A;  3QUV A;  3AI9 X;  4YQO A;  1NS5 A;  4YQS A;  1RCS A;  4YVI A;  4FAK A;  3ONP A;  2OZ9 R;  1X7O A;  2QMM A;  2XDI A;  4CNF A;  1V2X A;  4YQ9 A;  1J85 A;  3L8U A;  4YVH A;  1UAK A;  4JWG A;  4CND A;  4YQJ A;  1VHK A;  3KY7 A;  1WRS R;  4JAL A;  3OIN A;  4MCC A;  1GZ0 A;  4JWH A;  4YPZ A;  1MI7 R;  1TRO A;  3AIA A;  4PZK A;  3E5Y A;  4YQ1 A;  2I6D A;  1K3R A;  3KTY A;  4H3Y A;  3NK7 A;  3WRP A;  2CX8 A;  1X7P A;  4YVK A;  1JHG A;  2O3A A; 
#chains in the Genus database with same CATH homology
 3KW2 A;  4J3C A;  1UAL A;  1ZJR A;  4YQG A;  2Z0Y A;  3IEF A;  1UAJ A;  4YQ8 A;  4YQP A;  4YQ5 A;  1NXZ A;  4YQ7 A;  4YQ6 A;  2EGW A;  4CNG A;  4KDZ A;  5GMB A;  5CO4 A;  4YQK A;  4IG6 A;  4YQA A;  4JAK A;  4YQN A;  1VH0 A;  3DCM X;  3BBD A;  4YQQ A;  3BBE A;  4YPY A;  4YPX A;  4YQ2 A;  4YQR A;  3NK6 A;  5FAI A;  5GM8 A;  4RG1 A;  4YQ4 A;  4YQ3 A;  4XBO A;  3KNU A;  4YQD A;  1IPA A;  3N4J A;  3AXZ A;  4YVJ A;  3ILK A;  3OII A;  1UAM A;  4X3M A;  4YQB A;  4E8B A;  4YVG A;  4FMW A;  1O6D A;  1TO0 A;  1V6Z A;  2EGV A;  4YQL A;  2QWV A;  4YQC A;  3OIJ A;  4X3L A;  4L69 A;  4MCD A;  2YY8 A;  2V3K A;  3O7B A;  1VHY A;  4JWJ A;  4YQT A;  1OY5 A;  4H3Z A;  1MXI A;  3GYQ A;  3N4K A;  4YQI A;  4YPW A;  4YQ0 A;  4MCB A;  4KGN A;  3BBH A;  1P9P A;  1Z85 A;  2V3J A;  4JWF A;  5GMC A;  4CNE A;  3IC6 A;  2HA8 A;  5D9F A;  3QUV A;  3AI9 X;  4YQO A;  1NS5 A;  4YQS A;  4YVI A;  4FAK A;  3ONP A;  1X7O A;  2QMM A;  4CNF A;  1V2X A;  4YQ9 A;  1J85 A;  3L8U A;  4YVH A;  1UAK A;  4JWG A;  4CND A;  4YQJ A;  1VHK A;  3KY7 A;  4JAL A;  3OIN A;  4MCC A;  1GZ0 A;  4JWH A;  4YPZ A;  3AIA A;  4PZK A;  3E5Y A;  4YQ1 A;  2I6D A;  1K3R A;  3KTY A;  4H3Y A;  3NK7 A;  2CX8 A;  1X7P A;  4YVK A;  2O3A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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