4MCDA

Hintrmd in complex with 5-phenylthieno[2,3-d]pyrimidin-4(3h)-one
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
Knots found
sequence length
246
structure length
237
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae rd kw20
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 69
structure length 237
sequence length 246
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mcdA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mcdA01
4YQ4A 4JAKA 1Z85A 4MCBA 2V3KA 4CNEA 4YQ9A 3AI9X 3OIJA 4YQ8A 5GM8A 4MCDA 4YVIA 4RG1A 4H3ZA 2I6DA 4YQIA 3KY7A 1GZ0A 1NXZA 1O6DA 1VHYA 1X7OA 2QWVA 2YY8A 3BBDA 4YQBA 4YPZA 1V6ZA 2EGWA 4YQ7A 4IG6A 3ILKA 2V3JA 4YVGA 3QUVA 4YQ2A 4YQQA 4YPYA 3AXZA 3DCMX 5GMBA 1UAJA 2Z0YA 4MCCA 2EGVA 2HA8A 4YQCA 1UALA 4YQ3A 3OINA 4CNGA 4KGNA 5GMCA 4YVHA 3BBHA 4YQNA 4YPXA 4YQ6A 4YVKA 3KW2A 4YVJA 1P9PA 4YQSA 3IEFA 4YQ0A 4J3CA 5FAIA 3KNUA 1OY5A 4PZKA 2O3AA 1K3RA 3GYQA 4YQDA 3KTYA 4KDZA 4E8BA 4YQAA 4YQ5A 1X7PA 1NS5A 3BBEA 5CO4A 4YQTA 2QMMA 4YQPA 4X3LA 1MXIA 4XBOA 1UAKA 4YQLA 4FAKA 1J85A 3OIIA 4YQGA 2CX8A 1ZJRA 4CNFA 1IPAA 1VHKA 1VH0A 3NK7A 4YQOA 3AIAA 4YQJA 3O7BA 4YQKA 3N4JA 1UAMA 4JALA 3N4KA 3NK6A 4YQ1A 4YPWA 5D9FA 4L69A 4X3MA 1TO0A 3L8UA 1V2XA 4YQRA 3E5YA 4CNDA 3IC6A 4H3YA 3ONPA
chains in the Genus database with same CATH superfamily
4YQ4A 1RCSA 4JAKA 1Z85A 4MCBA 2V3KA 4CNEA 4YQ9A 3AI9X 3G1CA 3OIJA 4YQ8A 1ZT9A 5GM8A 4MCDA 4YVIA 4RG1A 4H3ZA 2I6DA 4YQIA 3KY7A 1GZ0A 1NXZA 1WRTR 1O6DA 1VHYA 1X7OA 2QWVA 2YY8A 3BBDA 4YQBA 4YPZA 1V6ZA 2EGWA 4YQ7A 4IG6A 3ILKA 2V3JA 4YVGA 3QUVA 4JWHA 4YQ2A 4YQQA 4YPYA 3AXZA 3DCMX 5GMBA 1UAJA 2Z0YA 3KORA 4MCCA 2EGVA 1WRSR 2HA8A 4YQCA 1MI7R 1UALA 4YQ3A 3OINA 4CNGA 4KGNA 5GMCA 4YVHA 3BBHA 1WRPR 4YQNA 4YPXA 4YQ6A 1JHGA 4YVKA 3KW2A 4YVJA 1P9PA 4YQSA 3IEFA 4YQ0A 4J3CA 5FAIA 3KNUA 1OY5A 3FRWA 4PZKA 2O3AA 1K3RA 3GYQA 4YQDA 3KTYA 4KDZA 4E8BA 4YQAA 4JWJA 2XDIA 4YQ5A 3SSWN 1X7PA 1NS5A 3BBEA 5CO4A 4YQTA 2QMMA 4YQPA 4X3LA 1MXIA 4XBOA 3WRPA 1UAKA 4YQLA 4JWGA 4FAKA 1J85A 3OIIA 2OZ9R 4YQGA 4FMWA 2CX8A 1ZJRA 4CNFA 1IPAA 1VHKA 1VH0A 3NK7A 4YQOA 3AIAA 4YQJA 1TROA 3O7BA 1TRRA 4YQKA 3N4JA 1UAMA 4JALA 3N4KA 3NK6A 4YQ1A 4YPWA 5D9FA 3SSXN 1CO0A 4L69A 4X3MA 1TO0A 3L8UA 1V2XA 4JWFA 4YQRA 3E5YA 4CNDA 3IC6A 4H3YA 3ONPA
chains in the Genus database with same CATH topology
4YQ4A 4JAKA 1Z85A 4MCBA 2V3KA 4CNEA 4YQ9A 3AI9X 3OIJA 4YQ8A 5GM8A 4MCDA 4YVIA 4RG1A 4H3ZA 2I6DA 4YQIA 3KY7A 1GZ0A 1NXZA 1O6DA 1VHYA 1X7OA 2QWVA 2YY8A 3BBDA 4YQBA 4YPZA 1V6ZA 2EGWA 4YQ7A 4IG6A 3ILKA 2V3JA 4YVGA 3QUVA 4JWHA 4YQ2A 4YQQA 4YPYA 3AXZA 3DCMX 5GMBA 1UAJA 2Z0YA 4MCCA 2EGVA 2HA8A 4YQCA 1UALA 4YQ3A 3OINA 4CNGA 4KGNA 5GMCA 4YVHA 3BBHA 4YQNA 4YPXA 4YQ6A 4YVKA 3KW2A 4YVJA 1P9PA 4YQSA 3IEFA 4YQ0A 4J3CA 5FAIA 3KNUA 1OY5A 4PZKA 2O3AA 1K3RA 3GYQA 4YQDA 3KTYA 4KDZA 4E8BA 4YQAA 4JWJA 4YQ5A 1X7PA 1NS5A 3BBEA 5CO4A 4YQTA 2QMMA 4YQPA 4X3LA 1MXIA 4XBOA 1UAKA 4YQLA 4JWGA 4FAKA 1J85A 3OIIA 4YQGA 4FMWA 2CX8A 1ZJRA 4CNFA 1IPAA 1VHKA 1VH0A 3NK7A 4YQOA 3AIAA 4YQJA 3O7BA 4YQKA 3N4JA 1UAMA 4JALA 3N4KA 3NK6A 4YQ1A 4YPWA 5D9FA 4L69A 4X3MA 1TO0A 3L8UA 1V2XA 4JWFA 4YQRA 3E5YA 4CNDA 3IC6A 4H3YA 3ONPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YQ4 A;  4JAK A;  1Z85 A;  4MCB A;  2V3K A;  4CNE A;  4YQ9 A;  3AI9 X;  3OIJ A;  4YQ8 A;  5GM8 A;  4MCD A;  4YVI A;  4RG1 A;  4H3Z A;  2I6D A;  4YQI A;  3KY7 A;  1GZ0 A;  1NXZ A;  1O6D A;  1VHY A;  1X7O A;  2QWV A;  2YY8 A;  3BBD A;  4YQB A;  4YPZ A;  1V6Z A;  2EGW A;  4YQ7 A;  4IG6 A;  3ILK A;  2V3J A;  4YVG A;  3QUV A;  4YQ2 A;  4YQQ A;  4YPY A;  3AXZ A;  3DCM X;  5GMB A;  1UAJ A;  2Z0Y A;  4MCC A;  2EGV A;  2HA8 A;  4YQC A;  1UAL A;  4YQ3 A;  3OIN A;  4CNG A;  4KGN A;  5GMC A;  4YVH A;  3BBH A;  4YQN A;  4YPX A;  4YQ6 A;  4YVK A;  3KW2 A;  4YVJ A;  1P9P A;  4YQS A;  3IEF A;  4YQ0 A;  4J3C A;  5FAI A;  3KNU A;  1OY5 A;  4PZK A;  2O3A A;  1K3R A;  3GYQ A;  4YQD A;  3KTY A;  4KDZ A;  4E8B A;  4YQA A;  4YQ5 A;  1X7P A;  1NS5 A;  3BBE A;  5CO4 A;  4YQT A;  2QMM A;  4YQP A;  4X3L A;  1MXI A;  4XBO A;  1UAK A;  4YQL A;  4FAK A;  1J85 A;  3OII A;  4YQG A;  2CX8 A;  1ZJR A;  4CNF A;  1IPA A;  1VHK A;  1VH0 A;  3NK7 A;  4YQO A;  3AIA A;  4YQJ A;  3O7B A;  4YQK A;  3N4J A;  1UAM A;  4JAL A;  3N4K A;  3NK6 A;  4YQ1 A;  4YPW A;  5D9F A;  4L69 A;  4X3M A;  1TO0 A;  3L8U A;  1V2X A;  4YQR A;  3E5Y A;  4CND A;  3IC6 A;  4H3Y A;  3ONP A; 
#chains in the Genus database with same CATH topology
 4YQ4 A;  1RCS A;  4JAK A;  1Z85 A;  4MCB A;  2V3K A;  4CNE A;  4YQ9 A;  3AI9 X;  3G1C A;  3OIJ A;  4YQ8 A;  1ZT9 A;  5GM8 A;  4MCD A;  4YVI A;  4RG1 A;  4H3Z A;  2I6D A;  4YQI A;  3KY7 A;  1GZ0 A;  1NXZ A;  1WRT R;  1O6D A;  1VHY A;  1X7O A;  2QWV A;  2YY8 A;  3BBD A;  4YQB A;  4YPZ A;  1V6Z A;  2EGW A;  4YQ7 A;  4IG6 A;  3ILK A;  2V3J A;  4YVG A;  3QUV A;  4JWH A;  4YQ2 A;  4YQQ A;  4YPY A;  3AXZ A;  3DCM X;  5GMB A;  1UAJ A;  2Z0Y A;  3KOR A;  4MCC A;  2EGV A;  1WRS R;  2HA8 A;  4YQC A;  1MI7 R;  1UAL A;  4YQ3 A;  3OIN A;  4CNG A;  4KGN A;  5GMC A;  4YVH A;  3BBH A;  1WRP R;  4YQN A;  4YPX A;  4YQ6 A;  1JHG A;  4YVK A;  3KW2 A;  4YVJ A;  1P9P A;  4YQS A;  3IEF A;  4YQ0 A;  4J3C A;  5FAI A;  3KNU A;  1OY5 A;  3FRW A;  4PZK A;  2O3A A;  1K3R A;  3GYQ A;  4YQD A;  3KTY A;  4KDZ A;  4E8B A;  4YQA A;  4JWJ A;  2XDI A;  4YQ5 A;  3SSW N;  1X7P A;  1NS5 A;  3BBE A;  5CO4 A;  4YQT A;  2QMM A;  4YQP A;  4X3L A;  1MXI A;  4XBO A;  3WRP A;  1UAK A;  4YQL A;  4JWG A;  4FAK A;  1J85 A;  3OII A;  2OZ9 R;  4YQG A;  4FMW A;  2CX8 A;  1ZJR A;  4CNF A;  1IPA A;  1VHK A;  1VH0 A;  3NK7 A;  4YQO A;  3AIA A;  4YQJ A;  1TRO A;  3O7B A;  1TRR A;  4YQK A;  3N4J A;  1UAM A;  4JAL A;  3N4K A;  3NK6 A;  4YQ1 A;  4YPW A;  5D9F A;  3SSX N;  1CO0 A;  4L69 A;  4X3M A;  1TO0 A;  3L8U A;  1V2X A;  4JWF A;  4YQR A;  3E5Y A;  4CND A;  3IC6 A;  4H3Y A;  3ONP A; 
#chains in the Genus database with same CATH homology
 4YQ4 A;  4JAK A;  1Z85 A;  4MCB A;  2V3K A;  4CNE A;  4YQ9 A;  3AI9 X;  3OIJ A;  4YQ8 A;  5GM8 A;  4MCD A;  4YVI A;  4RG1 A;  4H3Z A;  2I6D A;  4YQI A;  3KY7 A;  1GZ0 A;  1NXZ A;  1O6D A;  1VHY A;  1X7O A;  2QWV A;  2YY8 A;  3BBD A;  4YQB A;  4YPZ A;  1V6Z A;  2EGW A;  4YQ7 A;  4IG6 A;  3ILK A;  2V3J A;  4YVG A;  3QUV A;  4JWH A;  4YQ2 A;  4YQQ A;  4YPY A;  3AXZ A;  3DCM X;  5GMB A;  1UAJ A;  2Z0Y A;  4MCC A;  2EGV A;  2HA8 A;  4YQC A;  1UAL A;  4YQ3 A;  3OIN A;  4CNG A;  4KGN A;  5GMC A;  4YVH A;  3BBH A;  4YQN A;  4YPX A;  4YQ6 A;  4YVK A;  3KW2 A;  4YVJ A;  1P9P A;  4YQS A;  3IEF A;  4YQ0 A;  4J3C A;  5FAI A;  3KNU A;  1OY5 A;  4PZK A;  2O3A A;  1K3R A;  3GYQ A;  4YQD A;  3KTY A;  4KDZ A;  4E8B A;  4YQA A;  4JWJ A;  4YQ5 A;  1X7P A;  1NS5 A;  3BBE A;  5CO4 A;  4YQT A;  2QMM A;  4YQP A;  4X3L A;  1MXI A;  4XBO A;  1UAK A;  4YQL A;  4JWG A;  4FAK A;  1J85 A;  3OII A;  4YQG A;  4FMW A;  2CX8 A;  1ZJR A;  4CNF A;  1IPA A;  1VHK A;  1VH0 A;  3NK7 A;  4YQO A;  3AIA A;  4YQJ A;  3O7B A;  4YQK A;  3N4J A;  1UAM A;  4JAL A;  3N4K A;  3NK6 A;  4YQ1 A;  4YPW A;  5D9F A;  4L69 A;  4X3M A;  1TO0 A;  3L8U A;  1V2X A;  4JWF A;  4YQR A;  3E5Y A;  4CND A;  3IC6 A;  4H3Y A;  3ONP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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