4YQSA

Crystal structure of trmd, a m1g37 trna methyltransferase with sam-competitive compounds
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
Knots found
sequence length
248
structure length
237
Chain Sequence
SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGDGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd)
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 71
structure length 237
sequence length 248
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4yqsA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4yqsA01
3OINA 1VHKA 2QWVA 1UAJA 4YQ8A 3OIJA 1TO0A 3E5YA 5GMBA 3IEFA 4YQLA 4CNFA 4YQ5A 4YQOA 4YQGA 4JALA 4MCBA 1X7OA 3QUVA 1V2XA 5GMCA 3DCMX 4YVHA 4YQCA 4YQPA 1ZJRA 4KDZA 3N4KA 4J3CA 3OIIA 4YQ6A 1Z85A 4YPYA 3KY7A 1VH0A 5D9FA 1IPAA 4YQIA 4YQDA 1K3RA 1P9PA 5GM8A 4YQ7A 3BBDA 4E8BA 3IC6A 3O7BA 3BBEA 4YQQA 4X3MA 3AI9X 3KW2A 2HA8A 5CO4A 4KGNA 3KTYA 3KNUA 4IG6A 4YQTA 4YQSA 4H3ZA 1NS5A 1UAKA 1V6ZA 2YY8A 4CNGA 1VHYA 1X7PA 4YVKA 2CX8A 1UALA 4JAKA 4CNEA 3AIAA 4MCCA 4L69A 3ILKA 4PZKA 4YQJA 1J85A 3NK7A 4CNDA 4YQ2A 2V3JA 2V3KA 4YPXA 4YQ0A 4YVJA 3N4JA 4YVGA 1OY5A 1MXIA 4MCDA 4YQAA 5FAIA 2Z0YA 2QMMA 1O6DA 2EGVA 4FAKA 1NXZA 4YVIA 2I6DA 4YQ9A 4YQNA 2O3AA 3GYQA 3AXZA 3NK6A 4XBOA 4YQBA 2EGWA 4YQ4A 4YQKA 4YPZA 4YQRA 3BBHA 4YQ1A 3L8UA 1UAMA 4H3YA 4YQ3A 4RG1A 4YPWA 1GZ0A 3ONPA 4X3LA
chains in the Genus database with same CATH superfamily
3WRPA 3OINA 3SSWN 1VHKA 2QWVA 1UAJA 1ZT9A 4YQ8A 3OIJA 1TO0A 3E5YA 3KORA 5GMBA 2OZ9R 3IEFA 4FMWA 1WRTR 4JWJA 4YQLA 4CNFA 4YQ5A 4YQOA 4YQGA 4JALA 4MCBA 1X7OA 3QUVA 1V2XA 4JWHA 5GMCA 3DCMX 4YVHA 4YQCA 4YQPA 1ZJRA 4KDZA 3N4KA 4J3CA 3OIIA 4YQ6A 1Z85A 4YPYA 3KY7A 1VH0A 5D9FA 1IPAA 4YQIA 4YQDA 1K3RA 1P9PA 5GM8A 4YQ7A 3BBDA 4E8BA 3SSXN 3IC6A 3O7BA 3BBEA 4YQQA 4X3MA 3AI9X 3KW2A 2HA8A 5CO4A 4KGNA 3KTYA 3KNUA 4JWGA 1WRPR 4IG6A 4YQTA 4YQSA 4H3ZA 1NS5A 1UAKA 2XDIA 1V6ZA 1JHGA 2YY8A 4CNGA 1VHYA 1X7PA 3FRWA 1TROA 4YVKA 2CX8A 1UALA 4JAKA 4CNEA 3AIAA 4MCCA 4L69A 3ILKA 4PZKA 4YQJA 1J85A 3NK7A 4CNDA 4YQ2A 2V3JA 2V3KA 4YPXA 4YQ0A 1WRSR 4YVJA 3N4JA 1MI7R 4YVGA 1OY5A 1MXIA 4MCDA 4YQAA 5FAIA 2Z0YA 2QMMA 1O6DA 2EGVA 4FAKA 1TRRA 1NXZA 4YVIA 2I6DA 4YQ9A 4YQNA 2O3AA 3GYQA 3AXZA 3NK6A 4XBOA 4YQBA 3G1CA 2EGWA 4YQ4A 1CO0A 1RCSA 4YQKA 4JWFA 4YPZA 4YQRA 3BBHA 4YQ1A 3L8UA 1UAMA 4H3YA 4YQ3A 4RG1A 4YPWA 1GZ0A 3ONPA 4X3LA
chains in the Genus database with same CATH topology
3OINA 1VHKA 2QWVA 1UAJA 4YQ8A 3OIJA 1TO0A 3E5YA 5GMBA 3IEFA 4FMWA 4JWJA 4YQLA 4CNFA 4YQ5A 4YQOA 4YQGA 4JALA 4MCBA 1X7OA 3QUVA 1V2XA 4JWHA 5GMCA 3DCMX 4YVHA 4YQCA 4YQPA 1ZJRA 4KDZA 3N4KA 4J3CA 3OIIA 4YQ6A 1Z85A 4YPYA 3KY7A 1VH0A 5D9FA 1IPAA 4YQIA 4YQDA 1K3RA 1P9PA 5GM8A 4YQ7A 3BBDA 4E8BA 3IC6A 3O7BA 3BBEA 4YQQA 4X3MA 3AI9X 3KW2A 2HA8A 5CO4A 4KGNA 3KTYA 3KNUA 4JWGA 4IG6A 4YQTA 4YQSA 4H3ZA 1NS5A 1UAKA 1V6ZA 2YY8A 4CNGA 1VHYA 1X7PA 4YVKA 2CX8A 1UALA 4JAKA 4CNEA 3AIAA 4MCCA 4L69A 3ILKA 4PZKA 4YQJA 1J85A 3NK7A 4CNDA 4YQ2A 2V3JA 2V3KA 4YPXA 4YQ0A 4YVJA 3N4JA 4YVGA 1OY5A 1MXIA 4MCDA 4YQAA 5FAIA 2Z0YA 2QMMA 1O6DA 2EGVA 4FAKA 1NXZA 4YVIA 2I6DA 4YQ9A 4YQNA 2O3AA 3GYQA 3AXZA 3NK6A 4XBOA 4YQBA 2EGWA 4YQ4A 4YQKA 4JWFA 4YPZA 4YQRA 3BBHA 4YQ1A 3L8UA 1UAMA 4H3YA 4YQ3A 4RG1A 4YPWA 1GZ0A 3ONPA 4X3LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OIN A;  1VHK A;  2QWV A;  1UAJ A;  4YQ8 A;  3OIJ A;  1TO0 A;  3E5Y A;  5GMB A;  3IEF A;  4YQL A;  4CNF A;  4YQ5 A;  4YQO A;  4YQG A;  4JAL A;  4MCB A;  1X7O A;  3QUV A;  1V2X A;  5GMC A;  3DCM X;  4YVH A;  4YQC A;  4YQP A;  1ZJR A;  4KDZ A;  3N4K A;  4J3C A;  3OII A;  4YQ6 A;  1Z85 A;  4YPY A;  3KY7 A;  1VH0 A;  5D9F A;  1IPA A;  4YQI A;  4YQD A;  1K3R A;  1P9P A;  5GM8 A;  4YQ7 A;  3BBD A;  4E8B A;  3IC6 A;  3O7B A;  3BBE A;  4YQQ A;  4X3M A;  3AI9 X;  3KW2 A;  2HA8 A;  5CO4 A;  4KGN A;  3KTY A;  3KNU A;  4IG6 A;  4YQT A;  4YQS A;  4H3Z A;  1NS5 A;  1UAK A;  1V6Z A;  2YY8 A;  4CNG A;  1VHY A;  1X7P A;  4YVK A;  2CX8 A;  1UAL A;  4JAK A;  4CNE A;  3AIA A;  4MCC A;  4L69 A;  3ILK A;  4PZK A;  4YQJ A;  1J85 A;  3NK7 A;  4CND A;  4YQ2 A;  2V3J A;  2V3K A;  4YPX A;  4YQ0 A;  4YVJ A;  3N4J A;  4YVG A;  1OY5 A;  1MXI A;  4MCD A;  4YQA A;  5FAI A;  2Z0Y A;  2QMM A;  1O6D A;  2EGV A;  4FAK A;  1NXZ A;  4YVI A;  2I6D A;  4YQ9 A;  4YQN A;  2O3A A;  3GYQ A;  3AXZ A;  3NK6 A;  4XBO A;  4YQB A;  2EGW A;  4YQ4 A;  4YQK A;  4YPZ A;  4YQR A;  3BBH A;  4YQ1 A;  3L8U A;  1UAM A;  4H3Y A;  4YQ3 A;  4RG1 A;  4YPW A;  1GZ0 A;  3ONP A;  4X3L A; 
#chains in the Genus database with same CATH topology
 3WRP A;  3OIN A;  3SSW N;  1VHK A;  2QWV A;  1UAJ A;  1ZT9 A;  4YQ8 A;  3OIJ A;  1TO0 A;  3E5Y A;  3KOR A;  5GMB A;  2OZ9 R;  3IEF A;  4FMW A;  1WRT R;  4JWJ A;  4YQL A;  4CNF A;  4YQ5 A;  4YQO A;  4YQG A;  4JAL A;  4MCB A;  1X7O A;  3QUV A;  1V2X A;  4JWH A;  5GMC A;  3DCM X;  4YVH A;  4YQC A;  4YQP A;  1ZJR A;  4KDZ A;  3N4K A;  4J3C A;  3OII A;  4YQ6 A;  1Z85 A;  4YPY A;  3KY7 A;  1VH0 A;  5D9F A;  1IPA A;  4YQI A;  4YQD A;  1K3R A;  1P9P A;  5GM8 A;  4YQ7 A;  3BBD A;  4E8B A;  3SSX N;  3IC6 A;  3O7B A;  3BBE A;  4YQQ A;  4X3M A;  3AI9 X;  3KW2 A;  2HA8 A;  5CO4 A;  4KGN A;  3KTY A;  3KNU A;  4JWG A;  1WRP R;  4IG6 A;  4YQT A;  4YQS A;  4H3Z A;  1NS5 A;  1UAK A;  2XDI A;  1V6Z A;  1JHG A;  2YY8 A;  4CNG A;  1VHY A;  1X7P A;  3FRW A;  1TRO A;  4YVK A;  2CX8 A;  1UAL A;  4JAK A;  4CNE A;  3AIA A;  4MCC A;  4L69 A;  3ILK A;  4PZK A;  4YQJ A;  1J85 A;  3NK7 A;  4CND A;  4YQ2 A;  2V3J A;  2V3K A;  4YPX A;  4YQ0 A;  1WRS R;  4YVJ A;  3N4J A;  1MI7 R;  4YVG A;  1OY5 A;  1MXI A;  4MCD A;  4YQA A;  5FAI A;  2Z0Y A;  2QMM A;  1O6D A;  2EGV A;  4FAK A;  1TRR A;  1NXZ A;  4YVI A;  2I6D A;  4YQ9 A;  4YQN A;  2O3A A;  3GYQ A;  3AXZ A;  3NK6 A;  4XBO A;  4YQB A;  3G1C A;  2EGW A;  4YQ4 A;  1CO0 A;  1RCS A;  4YQK A;  4JWF A;  4YPZ A;  4YQR A;  3BBH A;  4YQ1 A;  3L8U A;  1UAM A;  4H3Y A;  4YQ3 A;  4RG1 A;  4YPW A;  1GZ0 A;  3ONP A;  4X3L A; 
#chains in the Genus database with same CATH homology
 3OIN A;  1VHK A;  2QWV A;  1UAJ A;  4YQ8 A;  3OIJ A;  1TO0 A;  3E5Y A;  5GMB A;  3IEF A;  4FMW A;  4JWJ A;  4YQL A;  4CNF A;  4YQ5 A;  4YQO A;  4YQG A;  4JAL A;  4MCB A;  1X7O A;  3QUV A;  1V2X A;  4JWH A;  5GMC A;  3DCM X;  4YVH A;  4YQC A;  4YQP A;  1ZJR A;  4KDZ A;  3N4K A;  4J3C A;  3OII A;  4YQ6 A;  1Z85 A;  4YPY A;  3KY7 A;  1VH0 A;  5D9F A;  1IPA A;  4YQI A;  4YQD A;  1K3R A;  1P9P A;  5GM8 A;  4YQ7 A;  3BBD A;  4E8B A;  3IC6 A;  3O7B A;  3BBE A;  4YQQ A;  4X3M A;  3AI9 X;  3KW2 A;  2HA8 A;  5CO4 A;  4KGN A;  3KTY A;  3KNU A;  4JWG A;  4IG6 A;  4YQT A;  4YQS A;  4H3Z A;  1NS5 A;  1UAK A;  1V6Z A;  2YY8 A;  4CNG A;  1VHY A;  1X7P A;  4YVK A;  2CX8 A;  1UAL A;  4JAK A;  4CNE A;  3AIA A;  4MCC A;  4L69 A;  3ILK A;  4PZK A;  4YQJ A;  1J85 A;  3NK7 A;  4CND A;  4YQ2 A;  2V3J A;  2V3K A;  4YPX A;  4YQ0 A;  4YVJ A;  3N4J A;  4YVG A;  1OY5 A;  1MXI A;  4MCD A;  4YQA A;  5FAI A;  2Z0Y A;  2QMM A;  1O6D A;  2EGV A;  4FAK A;  1NXZ A;  4YVI A;  2I6D A;  4YQ9 A;  4YQN A;  2O3A A;  3GYQ A;  3AXZ A;  3NK6 A;  4XBO A;  4YQB A;  2EGW A;  4YQ4 A;  4YQK A;  4JWF A;  4YPZ A;  4YQR A;  3BBH A;  4YQ1 A;  3L8U A;  1UAM A;  4H3Y A;  4YQ3 A;  4RG1 A;  4YPW A;  1GZ0 A;  3ONP A;  4X3L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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