1C3RA

Crystal structure of an hdac homolog complexed with trichostatin a
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
372
structure length
372
Chain Sequence
KKVKLIGTLDYGKYRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGNVAFNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKKGFKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEGVYLGGGGYHPYALARAWTLIWCELSGREVPEKLNNKAKELLKSIDFEEFDDEVDRSYMLETLKDPWRGGEVRKEVKDTLEKAKA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
pubmed doi rcsb
molecule tags Lyase
source organism Aquifex aeolicus
molecule keywords HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
total genus 133
structure length 372
sequence length 372
chains with identical sequence B
ec nomenclature
pdb deposition date 1999-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1c3rA00
1C3RA 2V5XA 4QA3A 3EW8A 5EFJD 4A69A 4BZ5A 4CBYA 3MZ3A 4QA2A 4QA4A 5G11A 5DC8A 5FUEA 3ZNRA 3Q9FA 5THTA 2VQVA 5D1CA 3Q9BA 4ZUOA 3C10A 5DC5A 4BKXB 5G3WA 4ZUMA 4LY1A 3MZ4A 2VCGA 3Q9EA 5G0GA 5G17A 2VQMA 3F06A 5G10A 3MAXA 5THUA 3ZNSA 4BZ6A 5G0IA 5EEMA 1C3PA 3SFHA 5DC7A 4BZ7A 4RN1A 2VQOA 5JI5A 4CBTA 3EZTA 3MENA 5EEKA 4RN0A 4QA7A 1ZZ1A 5BWZA 5G1CA 5G13A 1ZZ3A 5THSA 5EENA 1T64A 5EF7A 1C3SA 4RN2A 3C0ZA 5G1BA 1ZZ0A 5EEFA 5THVA 1W22A 2VQJA 4ZUPA 3RQDA 2VQWG 3SFFA 5EFKB 3Q9CA 2GH6A 5IWGA 2VQQA 5G0HA 1T69A 5D1BA 3F0RA 4ZURA 5EF8A 3EZPA 4LXZA 5G0YA 5G12A 5D1DA 5G0JA 5G0XA 4QA6A 4QA5A 4QA0A 5ICNB 2V5WA 4QA1A 3C0YA 5EFGA 4BZ8A 5EFBD 5A2SA 3EWFA 4BZ9A 1T67A 4ZUQA 5DC6A 3MZ6A 5LI3A 5EFHA 4ZUNA 3MZ7A 1VKGA 5G1AA 5IX0A 3F07A 5EEIA 5EFNA 4CQFA 5FCWA
chains in the Genus database with same CATH superfamily
1C3RA 1HQGA 2V5XA 3LHLA 4MXRA 4QA3A 3EW8A 1P8MA 3MFWA 4IE1A 4MYKA 5EFJD 4A69A 4RHLA 1WOGA 4BZ5A 4CBYA 3MZ3A 1WOIA 4QA2A 4Q3TA 1ZPGA 3E6VA 4MYLA 3SKKA 4QA4A 2EIVA 5G11A 5HJAA 5DC8A 5FUEA 1WVBA 2EF5A 1HQHA 1GQ6A 3Q9FA 4ITYA 4Q3VA 5THTA 3ZNRA 2ZAVA 2VQVA 5D1CA 1T5GA 3Q9BA 4GSMA 4DZ4A 3E6KA 4ZUOA 3C10A 5DC5A 4BKXB 5G3WA 1T4SA 3THHA 4ZUMA 4LY1A 4MYFA 3MZ4A 4HXQA 3GN0A 1T4TA 4Q40A 2VCGA 1GQ7A 3E8ZA 3Q9EA 5G0GA 5G17A 3THJA 3DJ8A 1P8QA 2VQMA 4Q3RC 4RHIA 4RHKA 3F06A 3SL1A 5G10A 3THEA 4Q41A 3MAXA 5THUA 3ZNSA 4BZ6A 3LP7A 4HZEA 5G0IA 5EEMA 1HQFA 4G3HA 4FCIA 4MYNA 1C3PA 3SFHA 5DC7A 1R1OA 1TBJA 4BZ7A 4RN1A 1P8OA 2VQOA 5JI5A 4CBTA 3EZTA 3MENA 4IU4A 4GWCA 2A0MA 2PLLA 4Q42A 5EEKA 1PQ3A 3E8QA 4RN0A 4IXVA 4QA7A 2EF4A 1ZZ1A 5BWZA 5G1CA 5G13A 1ZZ3A 5THSA 2CEVA 1TBHA 1HQ5A 5EENA 1T64A 2RLAA 3E9BA 5EF7A 4Q3SA 3SJTA 3TF3A 1C3SA 3PZLA 4RN2A 1P8SA 3C0ZA 4Q3UA 4RHQA 1ZZ0A 5G1BA 3M1RA 5EEFA 5THVA 1W22A 1ZPEA 3GMZA 5HJ9A 5CEVA 1TA1A 4GSZA 1P8PA 2VQJA 4ZUPA 3LP4A 3RQDA 3NIQA 2VQWG 3NIPA 3SFFA 1T4PA 4IU0A 5EFKB 4GSVA 3MMRA 1WVAA 1CEVA 3NIOA 3Q9CA 2GH6A 5IWGA 4RLAA 2AEBA 3MJLA 2VQQA 4RHMA 3RLAA 3CEVA 4IXUA 4IE2A 1T5FA 4Q3PA 2PHAA 1T69A 5G0HA 4RHJA 5D1BA 3F0RA 4ZURA 2PHOA 5EF8A 1P8RA 3EZPA 4LXZA 4IE3A 5G0YA 5G12A 1HQXA 1TBLA 5D1DA 5G0JA 5G0XA 4QA6A 4QA5A 4QA0A 5ICNB 2V5WA 1XFKA 3SL0A 4QA1A 3C0YA 5EFGA 1P8NA 1T4RA 5EFBD 3EWFA 4GWDA 4BZ8A 4BZ9A 5A2SA 1T67A 4CEVA 3TH7A 3KV2A 4FCKA 5RLAA 4ZUQA 4I06A 4Q3QA 5DC6A 1RLAA 3MZ6A 5LI3A 4IU1A 5EFHA 1D3VA 4ZUNA 4Q3RA 3MZ7A 4HWWA 1VKGA 3F80A 5G1AA 5IX0A 3MFVA 3F07A 4IU5A 5EEIA 5EFNA 4CQFA 1WOHA 5FCWA
chains in the Genus database with same CATH topology
1C3RA 2V5XA 4QA3A 3EW8A 5EFJD 4A69A 4BZ5A 4CBYA 3MZ3A 4QA2A 4QA4A 5G11A 5DC8A 5FUEA 3ZNRA 3Q9FA 5THTA 2VQVA 5D1CA 3Q9BA 4ZUOA 3C10A 5DC5A 4BKXB 5G3WA 4ZUMA 4LY1A 3MZ4A 2VCGA 3Q9EA 5G0GA 5G17A 2VQMA 3F06A 5G10A 3MAXA 5THUA 3ZNSA 4BZ6A 5G0IA 5EEMA 1C3PA 3SFHA 5DC7A 4BZ7A 4RN1A 2VQOA 5JI5A 4CBTA 3EZTA 3MENA 5EEKA 4RN0A 4QA7A 1ZZ1A 5BWZA 5G1CA 5G13A 1ZZ3A 5THSA 5EENA 1T64A 5EF7A 1C3SA 4RN2A 3C0ZA 5G1BA 1ZZ0A 5EEFA 5THVA 1W22A 2VQJA 4ZUPA 3RQDA 2VQWG 3SFFA 5EFKB 3Q9CA 2GH6A 5IWGA 2VQQA 5G0HA 1T69A 5D1BA 3F0RA 4ZURA 5EF8A 3EZPA 4LXZA 5G0YA 5G12A 5D1DA 5G0JA 5G0XA 4QA6A 4QA5A 4QA0A 5ICNB 2V5WA 4QA1A 3C0YA 5EFGA 4BZ8A 5EFBD 5A2SA 3EWFA 4BZ9A 1T67A 4ZUQA 5DC6A 3MZ6A 5LI3A 5EFHA 4ZUNA 3MZ7A 1VKGA 5G1AA 5IX0A 3F07A 5EEIA 5EFNA 4CQFA 5FCWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3R A;  2V5X A;  4QA3 A;  3EW8 A;  5EFJ D;  4A69 A;  4BZ5 A;  4CBY A;  3MZ3 A;  4QA2 A;  4QA4 A;  5G11 A;  5DC8 A;  5FUE A;  3ZNR A;  3Q9F A;  5THT A;  2VQV A;  5D1C A;  3Q9B A;  4ZUO A;  3C10 A;  5DC5 A;  4BKX B;  5G3W A;  4ZUM A;  4LY1 A;  3MZ4 A;  2VCG A;  3Q9E A;  5G0G A;  5G17 A;  2VQM A;  3F06 A;  5G10 A;  3MAX A;  5THU A;  3ZNS A;  4BZ6 A;  5G0I A;  5EEM A;  1C3P A;  3SFH A;  5DC7 A;  4BZ7 A;  4RN1 A;  2VQO A;  5JI5 A;  4CBT A;  3EZT A;  3MEN A;  5EEK A;  4RN0 A;  4QA7 A;  1ZZ1 A;  5BWZ A;  5G1C A;  5G13 A;  1ZZ3 A;  5THS A;  5EEN A;  1T64 A;  5EF7 A;  1C3S A;  4RN2 A;  3C0Z A;  5G1B A;  1ZZ0 A;  5EEF A;  5THV A;  1W22 A;  2VQJ A;  4ZUP A;  3RQD A;  2VQW G;  3SFF A;  5EFK B;  3Q9C A;  2GH6 A;  5IWG A;  2VQQ A;  5G0H A;  1T69 A;  5D1B A;  3F0R A;  4ZUR A;  5EF8 A;  3EZP A;  4LXZ A;  5G0Y A;  5G12 A;  5D1D A;  5G0J A;  5G0X A;  4QA6 A;  4QA5 A;  4QA0 A;  5ICN B;  2V5W A;  4QA1 A;  3C0Y A;  5EFG A;  4BZ8 A;  5EFB D;  5A2S A;  3EWF A;  4BZ9 A;  1T67 A;  4ZUQ A;  5DC6 A;  3MZ6 A;  5LI3 A;  5EFH A;  4ZUN A;  3MZ7 A;  1VKG A;  5G1A A;  5IX0 A;  3F07 A;  5EEI A;  5EFN A;  4CQF A;  5FCW A; 
#chains in the Genus database with same CATH topology
 1C3R A;  1HQG A;  2V5X A;  3LHL A;  4MXR A;  4QA3 A;  3EW8 A;  1P8M A;  3MFW A;  4IE1 A;  4MYK A;  5EFJ D;  4A69 A;  4RHL A;  1WOG A;  4BZ5 A;  4CBY A;  3MZ3 A;  1WOI A;  4QA2 A;  4Q3T A;  1ZPG A;  3E6V A;  4MYL A;  3SKK A;  4QA4 A;  2EIV A;  5G11 A;  5HJA A;  5DC8 A;  5FUE A;  1WVB A;  2EF5 A;  1HQH A;  1GQ6 A;  3Q9F A;  4ITY A;  4Q3V A;  5THT A;  3ZNR A;  2ZAV A;  2VQV A;  5D1C A;  1T5G A;  3Q9B A;  4GSM A;  4DZ4 A;  3E6K A;  4ZUO A;  3C10 A;  5DC5 A;  4BKX B;  5G3W A;  1T4S A;  3THH A;  4ZUM A;  4LY1 A;  4MYF A;  3MZ4 A;  4HXQ A;  3GN0 A;  1T4T A;  4Q40 A;  2VCG A;  1GQ7 A;  3E8Z A;  3Q9E A;  5G0G A;  5G17 A;  3THJ A;  3DJ8 A;  1P8Q A;  2VQM A;  4Q3R C;  4RHI A;  4RHK A;  3F06 A;  3SL1 A;  5G10 A;  3THE A;  4Q41 A;  3MAX A;  5THU A;  3ZNS A;  4BZ6 A;  3LP7 A;  4HZE A;  5G0I A;  5EEM A;  1HQF A;  4G3H A;  4FCI A;  4MYN A;  1C3P A;  3SFH A;  5DC7 A;  1R1O A;  1TBJ A;  4BZ7 A;  4RN1 A;  1P8O A;  2VQO A;  5JI5 A;  4CBT A;  3EZT A;  3MEN A;  4IU4 A;  4GWC A;  2A0M A;  2PLL A;  4Q42 A;  5EEK A;  1PQ3 A;  3E8Q A;  4RN0 A;  4IXV A;  4QA7 A;  2EF4 A;  1ZZ1 A;  5BWZ A;  5G1C A;  5G13 A;  1ZZ3 A;  5THS A;  2CEV A;  1TBH A;  1HQ5 A;  5EEN A;  1T64 A;  2RLA A;  3E9B A;  5EF7 A;  4Q3S A;  3SJT A;  3TF3 A;  1C3S A;  3PZL A;  4RN2 A;  1P8S A;  3C0Z A;  4Q3U A;  4RHQ A;  1ZZ0 A;  5G1B A;  3M1R A;  5EEF A;  5THV A;  1W22 A;  1ZPE A;  3GMZ A;  5HJ9 A;  5CEV A;  1TA1 A;  4GSZ A;  1P8P A;  2VQJ A;  4ZUP A;  3LP4 A;  3RQD A;  3NIQ A;  2VQW G;  3NIP A;  3SFF A;  1T4P A;  4IU0 A;  5EFK B;  4GSV A;  3MMR A;  1WVA A;  1CEV A;  3NIO A;  3Q9C A;  2GH6 A;  5IWG A;  4RLA A;  2AEB A;  3MJL A;  2VQQ A;  4RHM A;  3RLA A;  3CEV A;  4IXU A;  4IE2 A;  1T5F A;  4Q3P A;  2PHA A;  1T69 A;  5G0H A;  4RHJ A;  5D1B A;  3F0R A;  4ZUR A;  2PHO A;  5EF8 A;  1P8R A;  3EZP A;  4LXZ A;  4IE3 A;  5G0Y A;  5G12 A;  1HQX A;  1TBL A;  5D1D A;  5G0J A;  5G0X A;  4QA6 A;  4QA5 A;  4QA0 A;  5ICN B;  2V5W A;  1XFK A;  3SL0 A;  4QA1 A;  3C0Y A;  5EFG A;  1P8N A;  1T4R A;  5EFB D;  3EWF A;  4GWD A;  4BZ8 A;  4BZ9 A;  5A2S A;  1T67 A;  4CEV A;  3TH7 A;  3KV2 A;  4FCK A;  5RLA A;  4ZUQ A;  4I06 A;  4Q3Q A;  5DC6 A;  1RLA A;  3MZ6 A;  5LI3 A;  4IU1 A;  5EFH A;  1D3V A;  4ZUN A;  4Q3R A;  3MZ7 A;  4HWW A;  1VKG A;  3F80 A;  5G1A A;  5IX0 A;  3MFV A;  3F07 A;  4IU5 A;  5EEI A;  5EFN A;  4CQF A;  1WOH A;  5FCW A; 
#chains in the Genus database with same CATH homology
 1C3R A;  2V5X A;  4QA3 A;  3EW8 A;  5EFJ D;  4A69 A;  4BZ5 A;  4CBY A;  3MZ3 A;  4QA2 A;  4QA4 A;  5G11 A;  5DC8 A;  5FUE A;  3ZNR A;  3Q9F A;  5THT A;  2VQV A;  5D1C A;  3Q9B A;  4ZUO A;  3C10 A;  5DC5 A;  4BKX B;  5G3W A;  4ZUM A;  4LY1 A;  3MZ4 A;  2VCG A;  3Q9E A;  5G0G A;  5G17 A;  2VQM A;  3F06 A;  5G10 A;  3MAX A;  5THU A;  3ZNS A;  4BZ6 A;  5G0I A;  5EEM A;  1C3P A;  3SFH A;  5DC7 A;  4BZ7 A;  4RN1 A;  2VQO A;  5JI5 A;  4CBT A;  3EZT A;  3MEN A;  5EEK A;  4RN0 A;  4QA7 A;  1ZZ1 A;  5BWZ A;  5G1C A;  5G13 A;  1ZZ3 A;  5THS A;  5EEN A;  1T64 A;  5EF7 A;  1C3S A;  4RN2 A;  3C0Z A;  5G1B A;  1ZZ0 A;  5EEF A;  5THV A;  1W22 A;  2VQJ A;  4ZUP A;  3RQD A;  2VQW G;  3SFF A;  5EFK B;  3Q9C A;  2GH6 A;  5IWG A;  2VQQ A;  5G0H A;  1T69 A;  5D1B A;  3F0R A;  4ZUR A;  5EF8 A;  3EZP A;  4LXZ A;  5G0Y A;  5G12 A;  5D1D A;  5G0J A;  5G0X A;  4QA6 A;  4QA5 A;  4QA0 A;  5ICN B;  2V5W A;  4QA1 A;  3C0Y A;  5EFG A;  4BZ8 A;  5EFB D;  5A2S A;  3EWF A;  4BZ9 A;  1T67 A;  4ZUQ A;  5DC6 A;  3MZ6 A;  5LI3 A;  5EFH A;  4ZUN A;  3MZ7 A;  1VKG A;  5G1A A;  5IX0 A;  3F07 A;  5EEI A;  5EFN A;  4CQF A;  5FCW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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