2VQMA

Structure of hdac4 catalytic domain bound to a hydroxamic acid inhbitor
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
402
structure length
391
Chain Sequence
PRFTTGLVYDTLMLKHQCTCGHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HISTONE DEACETYLASE 4
publication title Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 135
structure length 391
sequence length 402
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 2vqmA00
3C0YA 2GH6A 5IX0A 3MAXA 5EF8A 3EZPA 5G0HA 1T69A 5D1BA 2VQJA 4CBYA 4BKXB 5EFJD 4RN2A 4QA7A 5DC5A 5EFHA 4A69A 2VQMA 4QA0A 3F06A 5G0XA 5EFBD 3MZ4A 4QA4A 3SFFA 5G0JA 5LI3A 5ICNB 2VQWG 5G10A 3ZNRA 4QA6A 5EEKA 3ZNSA 4BZ9A 5EEMA 3Q9BA 5DC7A 5G17A 5THVA 1C3SA 3C10A 2VQOA 4BZ8A 5EFGA 4BZ5A 5G11A 5D1DA 4CQFA 5THTA 4BZ6A 3Q9EA 2V5WA 5DC8A 1ZZ1A 1T67A 5A2SA 2VQVA 5JI5A 5DC6A 3MZ6A 3RQDA 1VKGA 5G1AA 3SFHA 3EW8A 4ZUQA 4RN1A 4CBTA 2V5XA 1W22A 3F0RA 5EEIA 5G13A 5G3WA 1ZZ3A 4ZUOA 4ZUMA 5THSA 4LXZA 5EFNA 4ZURA 1T64A 5IWGA 5EF7A 1C3PA 3Q9FA 5G12A 5FCWA 5G0GA 2VCGA 1C3RA 3EWFA 4QA3A 4QA5A 4RN0A 5G1CA 5EEFA 5FUEA 3F07A 5G0YA 3MZ3A 3C0ZA 4LY1A 5EFKB 5D1CA 5EENA 3EZTA 4QA2A 3MENA 4BZ7A 4ZUPA 3MZ7A 4ZUNA 5THUA 2VQQA 3Q9CA 5G0IA 5G1BA 1ZZ0A 5BWZA 4QA1A
chains in the Genus database with same CATH superfamily
2EIVA 3C0YA 2GH6A 4GSVA 5IX0A 3MAXA 5EF8A 2CEVA 1HQXA 3EZPA 5G0HA 1P8OA 1T69A 4Q3VA 1T4PA 5D1BA 2VQJA 4HWWA 4BKXB 4CBYA 1HQ5A 3MMRA 1T4SA 4QA7A 4RN2A 5DC5A 5EFHA 5EFJD 3NIOA 4A69A 4GSZA 2VQMA 4QA0A 3KV2A 4RHQA 4IXUA 3E8ZA 3F06A 5G0XA 5EFBD 4RHLA 3MZ4A 4I06A 4ITYA 4QA4A 3SFFA 5G0JA 5LI3A 3SL0A 5ICNB 2VQWG 4IXVA 5G10A 1TBLA 3ZNRA 1ZPGA 4QA6A 5EEKA 4Q41A 3TH7A 3ZNSA 4BZ9A 5EEMA 3Q9BA 1P8PA 4FCIA 4Q40A 5DC7A 5G17A 2AEBA 4FCKA 1TBJA 4GSMA 5THVA 1PQ3A 3LP7A 1WOHA 1C3SA 4IE2A 3C10A 4HXQA 2VQOA 3GN0A 4BZ8A 4Q3QA 3MFWA 3NIQA 4IE1A 5EFGA 4BZ5A 5G11A 1ZPEA 4IU1A 2EF5A 2PHAA 3MJLA 1HQFA 5D1DA 1TBHA 3E6KA 3CEVA 3SJTA 1CEVA 4CQFA 4IU0A 5THTA 1R1OA 2A0MA 4BZ6A 4DZ4A 3Q9EA 2V5WA 4CEVA 5DC8A 1ZZ1A 1P8QA 1T67A 5A2SA 1T5FA 2VQVA 5JI5A 4GWDA 5DC6A 3MZ6A 4Q3SA 3E9BA 2PLLA 3RQDA 4Q3TA 4Q3RC 1VKGA 2EF4A 5G1AA 4RHJA 3EW8A 4IU5A 3SFHA 3THEA 4RN1A 4ZUQA 1HQHA 1RLAA 1P8SA 4CBTA 4RHMA 1W22A 2V5XA 3F0RA 1HQGA 4IE3A 4MYNA 4Q42A 5EEIA 4Q3RA 2ZAVA 5G13A 5G3WA 5HJ9A 5CEVA 1WOGA 3NIPA 1ZZ3A 4ZUOA 3MFVA 3M1RA 3THJA 2PHOA 4Q3UA 4ZUMA 1WVBA 5THSA 4LXZA 3GMZA 5EFNA 4MYLA 1T64A 4ZURA 5IWGA 1D3VA 5EF7A 1C3PA 3Q9FA 5G12A 4RHKA 5FCWA 5G0GA 2VCGA 4Q3PA 5HJAA 3RLAA 4GWCA 1WOIA 1C3RA 3E6VA 3SL1A 3TF3A 3EWFA 4QA3A 4QA5A 1GQ6A 4MXRA 4RN0A 5RLAA 1T4TA 5EEFA 3LP4A 3F07A 5FUEA 5G1CA 3MZ3A 3C0ZA 4LY1A 5EFKB 5G0YA 5D1CA 3DJ8A 1P8MA 2RLAA 3EZTA 4MYKA 3MENA 4QA2A 1P8NA 5EENA 4BZ7A 3SKKA 1XFKA 1WVAA 4ZUPA 3THHA 3PZLA 4G3HA 1T4RA 3LHLA 3F80A 3MZ7A 4MYFA 4ZUNA 2VQQA 1P8RA 3Q9CA 5G0IA 5THUA 5G1BA 1ZZ0A 4IU4A 1T5GA 1GQ7A 4HZEA 5BWZA 4QA1A 1TA1A 4RLAA 3E8QA 4RHIA
chains in the Genus database with same CATH topology
3C0YA 2GH6A 5IX0A 3MAXA 5EF8A 3EZPA 5G0HA 1T69A 5D1BA 2VQJA 4CBYA 4BKXB 5EFJD 4RN2A 4QA7A 5DC5A 5EFHA 4A69A 2VQMA 4QA0A 3F06A 5G0XA 5EFBD 3MZ4A 4QA4A 3SFFA 5G0JA 5LI3A 5ICNB 2VQWG 5G10A 3ZNRA 4QA6A 5EEKA 3ZNSA 4BZ9A 5EEMA 3Q9BA 5DC7A 5G17A 5THVA 1C3SA 3C10A 2VQOA 4BZ8A 5EFGA 4BZ5A 5G11A 5D1DA 4CQFA 5THTA 4BZ6A 3Q9EA 2V5WA 5DC8A 1ZZ1A 1T67A 5A2SA 2VQVA 5JI5A 5DC6A 3MZ6A 3RQDA 1VKGA 5G1AA 3SFHA 3EW8A 4ZUQA 4RN1A 4CBTA 2V5XA 1W22A 3F0RA 5EEIA 5G13A 5G3WA 1ZZ3A 4ZUOA 4ZUMA 5THSA 4LXZA 5EFNA 4ZURA 1T64A 5IWGA 5EF7A 1C3PA 3Q9FA 5G12A 5FCWA 5G0GA 2VCGA 1C3RA 3EWFA 4QA3A 4QA5A 4RN0A 5G1CA 5EEFA 5FUEA 3F07A 5G0YA 3MZ3A 3C0ZA 4LY1A 5EFKB 5D1CA 5EENA 3EZTA 4QA2A 3MENA 4BZ7A 4ZUPA 3MZ7A 4ZUNA 5THUA 2VQQA 3Q9CA 5G0IA 5G1BA 1ZZ0A 5BWZA 4QA1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C0Y A;  2GH6 A;  5IX0 A;  3MAX A;  5EF8 A;  3EZP A;  5G0H A;  1T69 A;  5D1B A;  2VQJ A;  4CBY A;  4BKX B;  5EFJ D;  4RN2 A;  4QA7 A;  5DC5 A;  5EFH A;  4A69 A;  2VQM A;  4QA0 A;  3F06 A;  5G0X A;  5EFB D;  3MZ4 A;  4QA4 A;  3SFF A;  5G0J A;  5LI3 A;  5ICN B;  2VQW G;  5G10 A;  3ZNR A;  4QA6 A;  5EEK A;  3ZNS A;  4BZ9 A;  5EEM A;  3Q9B A;  5DC7 A;  5G17 A;  5THV A;  1C3S A;  3C10 A;  2VQO A;  4BZ8 A;  5EFG A;  4BZ5 A;  5G11 A;  5D1D A;  4CQF A;  5THT A;  4BZ6 A;  3Q9E A;  2V5W A;  5DC8 A;  1ZZ1 A;  1T67 A;  5A2S A;  2VQV A;  5JI5 A;  5DC6 A;  3MZ6 A;  3RQD A;  1VKG A;  5G1A A;  3SFH A;  3EW8 A;  4ZUQ A;  4RN1 A;  4CBT A;  2V5X A;  1W22 A;  3F0R A;  5EEI A;  5G13 A;  5G3W A;  1ZZ3 A;  4ZUO A;  4ZUM A;  5THS A;  4LXZ A;  5EFN A;  4ZUR A;  1T64 A;  5IWG A;  5EF7 A;  1C3P A;  3Q9F A;  5G12 A;  5FCW A;  5G0G A;  2VCG A;  1C3R A;  3EWF A;  4QA3 A;  4QA5 A;  4RN0 A;  5G1C A;  5EEF A;  5FUE A;  3F07 A;  5G0Y A;  3MZ3 A;  3C0Z A;  4LY1 A;  5EFK B;  5D1C A;  5EEN A;  3EZT A;  4QA2 A;  3MEN A;  4BZ7 A;  4ZUP A;  3MZ7 A;  4ZUN A;  5THU A;  2VQQ A;  3Q9C A;  5G0I A;  5G1B A;  1ZZ0 A;  5BWZ A;  4QA1 A; 
#chains in the Genus database with same CATH topology
 2EIV A;  3C0Y A;  2GH6 A;  4GSV A;  5IX0 A;  3MAX A;  5EF8 A;  2CEV A;  1HQX A;  3EZP A;  5G0H A;  1P8O A;  1T69 A;  4Q3V A;  1T4P A;  5D1B A;  2VQJ A;  4HWW A;  4BKX B;  4CBY A;  1HQ5 A;  3MMR A;  1T4S A;  4QA7 A;  4RN2 A;  5DC5 A;  5EFH A;  5EFJ D;  3NIO A;  4A69 A;  4GSZ A;  2VQM A;  4QA0 A;  3KV2 A;  4RHQ A;  4IXU A;  3E8Z A;  3F06 A;  5G0X A;  5EFB D;  4RHL A;  3MZ4 A;  4I06 A;  4ITY A;  4QA4 A;  3SFF A;  5G0J A;  5LI3 A;  3SL0 A;  5ICN B;  2VQW G;  4IXV A;  5G10 A;  1TBL A;  3ZNR A;  1ZPG A;  4QA6 A;  5EEK A;  4Q41 A;  3TH7 A;  3ZNS A;  4BZ9 A;  5EEM A;  3Q9B A;  1P8P A;  4FCI A;  4Q40 A;  5DC7 A;  5G17 A;  2AEB A;  4FCK A;  1TBJ A;  4GSM A;  5THV A;  1PQ3 A;  3LP7 A;  1WOH A;  1C3S A;  4IE2 A;  3C10 A;  4HXQ A;  2VQO A;  3GN0 A;  4BZ8 A;  4Q3Q A;  3MFW A;  3NIQ A;  4IE1 A;  5EFG A;  4BZ5 A;  5G11 A;  1ZPE A;  4IU1 A;  2EF5 A;  2PHA A;  3MJL A;  1HQF A;  5D1D A;  1TBH A;  3E6K A;  3CEV A;  3SJT A;  1CEV A;  4CQF A;  4IU0 A;  5THT A;  1R1O A;  2A0M A;  4BZ6 A;  4DZ4 A;  3Q9E A;  2V5W A;  4CEV A;  5DC8 A;  1ZZ1 A;  1P8Q A;  1T67 A;  5A2S A;  1T5F A;  2VQV A;  5JI5 A;  4GWD A;  5DC6 A;  3MZ6 A;  4Q3S A;  3E9B A;  2PLL A;  3RQD A;  4Q3T A;  4Q3R C;  1VKG A;  2EF4 A;  5G1A A;  4RHJ A;  3EW8 A;  4IU5 A;  3SFH A;  3THE A;  4RN1 A;  4ZUQ A;  1HQH A;  1RLA A;  1P8S A;  4CBT A;  4RHM A;  1W22 A;  2V5X A;  3F0R A;  1HQG A;  4IE3 A;  4MYN A;  4Q42 A;  5EEI A;  4Q3R A;  2ZAV A;  5G13 A;  5G3W A;  5HJ9 A;  5CEV A;  1WOG A;  3NIP A;  1ZZ3 A;  4ZUO A;  3MFV A;  3M1R A;  3THJ A;  2PHO A;  4Q3U A;  4ZUM A;  1WVB A;  5THS A;  4LXZ A;  3GMZ A;  5EFN A;  4MYL A;  1T64 A;  4ZUR A;  5IWG A;  1D3V A;  5EF7 A;  1C3P A;  3Q9F A;  5G12 A;  4RHK A;  5FCW A;  5G0G A;  2VCG A;  4Q3P A;  5HJA A;  3RLA A;  4GWC A;  1WOI A;  1C3R A;  3E6V A;  3SL1 A;  3TF3 A;  3EWF A;  4QA3 A;  4QA5 A;  1GQ6 A;  4MXR A;  4RN0 A;  5RLA A;  1T4T A;  5EEF A;  3LP4 A;  3F07 A;  5FUE A;  5G1C A;  3MZ3 A;  3C0Z A;  4LY1 A;  5EFK B;  5G0Y A;  5D1C A;  3DJ8 A;  1P8M A;  2RLA A;  3EZT A;  4MYK A;  3MEN A;  4QA2 A;  1P8N A;  5EEN A;  4BZ7 A;  3SKK A;  1XFK A;  1WVA A;  4ZUP A;  3THH A;  3PZL A;  4G3H A;  1T4R A;  3LHL A;  3F80 A;  3MZ7 A;  4MYF A;  4ZUN A;  2VQQ A;  1P8R A;  3Q9C A;  5G0I A;  5THU A;  5G1B A;  1ZZ0 A;  4IU4 A;  1T5G A;  1GQ7 A;  4HZE A;  5BWZ A;  4QA1 A;  1TA1 A;  4RLA A;  3E8Q A;  4RHI A; 
#chains in the Genus database with same CATH homology
 3C0Y A;  2GH6 A;  5IX0 A;  3MAX A;  5EF8 A;  3EZP A;  5G0H A;  1T69 A;  5D1B A;  2VQJ A;  4CBY A;  4BKX B;  5EFJ D;  4RN2 A;  4QA7 A;  5DC5 A;  5EFH A;  4A69 A;  2VQM A;  4QA0 A;  3F06 A;  5G0X A;  5EFB D;  3MZ4 A;  4QA4 A;  3SFF A;  5G0J A;  5LI3 A;  5ICN B;  2VQW G;  5G10 A;  3ZNR A;  4QA6 A;  5EEK A;  3ZNS A;  4BZ9 A;  5EEM A;  3Q9B A;  5DC7 A;  5G17 A;  5THV A;  1C3S A;  3C10 A;  2VQO A;  4BZ8 A;  5EFG A;  4BZ5 A;  5G11 A;  5D1D A;  4CQF A;  5THT A;  4BZ6 A;  3Q9E A;  2V5W A;  5DC8 A;  1ZZ1 A;  1T67 A;  5A2S A;  2VQV A;  5JI5 A;  5DC6 A;  3MZ6 A;  3RQD A;  1VKG A;  5G1A A;  3SFH A;  3EW8 A;  4ZUQ A;  4RN1 A;  4CBT A;  2V5X A;  1W22 A;  3F0R A;  5EEI A;  5G13 A;  5G3W A;  1ZZ3 A;  4ZUO A;  4ZUM A;  5THS A;  4LXZ A;  5EFN A;  4ZUR A;  1T64 A;  5IWG A;  5EF7 A;  1C3P A;  3Q9F A;  5G12 A;  5FCW A;  5G0G A;  2VCG A;  1C3R A;  3EWF A;  4QA3 A;  4QA5 A;  4RN0 A;  5G1C A;  5EEF A;  5FUE A;  3F07 A;  5G0Y A;  3MZ3 A;  3C0Z A;  4LY1 A;  5EFK B;  5D1C A;  5EEN A;  3EZT A;  4QA2 A;  3MEN A;  4BZ7 A;  4ZUP A;  3MZ7 A;  4ZUN A;  5THU A;  2VQQ A;  3Q9C A;  5G0I A;  5G1B A;  1ZZ0 A;  5BWZ A;  4QA1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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