5EF7A

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with hpob
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
358
structure length
358
Chain Sequence
SPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 143
structure length 358
sequence length 358
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5ef7A00
4CQFA 3Q9CA 5ICNB 5DC8A 4LY1A 3MAXA 3EZPA 5EEMA 5D1BA 4BZ6A 3Q9BA 4BZ5A 4BZ8A 4BZ7A 4RN1A 1C3SA 3C10A 3ZNRA 4QA6A 2VQOA 1ZZ0A 5D1CA 5G0YA 5G0IA 5THVA 5G12A 3EZTA 4ZUOA 2VQQA 1T69A 4QA2A 4ZUQA 5A2SA 5EEIA 4LXZA 3C0ZA 3SFFA 2VQMA 5EF7A 5G1BA 5LI3A 4RN0A 5EEKA 3C0YA 4ZUMA 5IWGA 5G1AA 5EFHA 1ZZ1A 3EW8A 5EFBD 5BWZA 4QA4A 2VQVA 3F06A 3Q9FA 5G11A 5G0GA 4QA5A 5FUEA 5IX0A 5EFGA 3Q9EA 5EFJD 5THSA 3MZ3A 5EENA 5G3WA 2GH6A 1T67A 3MZ6A 5EEFA 5EF8A 4A69A 5EFKB 1W22A 4ZURA 5D1DA 4CBYA 4CBTA 5THTA 5DC6A 5FCWA 4QA3A 3MENA 4QA0A 4ZUPA 4QA1A 3MZ4A 5JI5A 5EFNA 2VCGA 4QA7A 5G10A 4ZUNA 1C3PA 2V5XA 1T64A 5G13A 1VKGA 2V5WA 1C3RA 1ZZ3A 5G0JA 2VQJA 5DC7A 5G1CA 3SFHA 3F07A 5G0HA 5G17A 5G0XA 3EWFA 4RN2A 3F0RA 2VQWG 3MZ7A 3ZNSA 3RQDA 4BKXB 4BZ9A 5THUA 5DC5A
chains in the Genus database with same CATH superfamily
3NIOA 4RHIA 4CQFA 2EF4A 3Q9CA 5DC8A 5ICNB 4LY1A 4Q3VA 3MAXA 3LP7A 2AEBA 4Q3QA 3GMZA 3EZPA 3NIPA 5EEMA 1TBJA 5D1BA 3LP4A 4BZ6A 3Q9BA 4BZ5A 4HWWA 4GSZA 4BZ8A 3E9BA 4MYFA 3MFWA 4GSMA 4RN1A 4BZ7A 4CEVA 1C3SA 3C10A 4Q3SA 4Q40A 3ZNRA 4QA6A 1XFKA 2VQOA 1ZZ0A 5D1CA 4Q42A 5G0YA 5G0IA 5THVA 4DZ4A 4IE2A 3TF3A 5G12A 1TBLA 4RHQA 3EZTA 4Q3RA 4ITYA 4ZUOA 2VQQA 1T69A 4QA2A 4ZUQA 1RLAA 5EEIA 5A2SA 3MFVA 4LXZA 3C0ZA 4MYLA 3SFFA 3SJTA 4GSVA 2VQMA 5EF7A 1P8MA 1WOIA 1WOHA 5G1BA 5LI3A 1TA1A 1D3VA 3PZLA 4RN0A 3THJA 1T4PA 4FCKA 4Q3PA 5EEKA 5RLAA 3C0YA 4IXUA 4ZUMA 4RHJA 3GN0A 5IWGA 5G1AA 5EFHA 1HQHA 1WVAA 1ZZ1A 1WOGA 1ZPGA 2RLAA 3EW8A 3CEVA 4Q3TA 5EFBD 5BWZA 4Q3RC 2CEVA 1WVBA 4QA4A 2VQVA 1P8NA 3F06A 2EF5A 4Q41A 1HQGA 4IU5A 3Q9FA 4RLAA 3TH7A 5G11A 3MMRA 4HXQA 4IE3A 5G0GA 4QA5A 3RLAA 5FUEA 1HQFA 1P8PA 1HQ5A 5IX0A 4GWCA 5EFGA 1P8OA 3F80A 3Q9EA 1T5FA 2ZAVA 2PHAA 5EFJD 5THSA 1T5GA 3MZ3A 5EENA 3LHLA 1T4TA 5G3WA 2GH6A 1T67A 3MZ6A 5EEFA 5EF8A 4A69A 1T4RA 5EFKB 1W22A 1TBHA 2PLLA 4ZURA 5D1DA 4CBYA 3E8QA 4CBTA 4HZEA 1P8QA 4MXRA 5THTA 2A0MA 4G3HA 5DC6A 4FCIA 3SL1A 1ZPEA 5FCWA 3KV2A 3THHA 4QA3A 3MENA 4QA0A 4ZUPA 4MYKA 4QA1A 1T4SA 5HJ9A 4I06A 3NIQA 3MZ4A 4IU1A 1P8RA 4RHMA 3THEA 1HQXA 3MJLA 3SKKA 5JI5A 4GWDA 5EFNA 2VCGA 4Q3UA 3M1RA 4QA7A 5G10A 4ZUNA 1C3PA 2V5XA 1T64A 5G13A 1GQ7A 1VKGA 2V5WA 1C3RA 1ZZ3A 4IU0A 2VQJA 5G0JA 2PHOA 5HJAA 1P8SA 3E8ZA 4IE1A 3DJ8A 5DC7A 1GQ6A 2EIVA 5G1CA 4RHKA 3SFHA 4MYNA 3F07A 4IXVA 3E6KA 5G0HA 5G0XA 5G17A 1CEVA 3EWFA 4RN2A 4IU4A 3F0RA 2VQWG 5CEVA 3MZ7A 1PQ3A 3SL0A 3ZNSA 3E6VA 3RQDA 4BKXB 4BZ9A 4RHLA 5THUA 1R1OA 5DC5A
chains in the Genus database with same CATH topology
4CQFA 3Q9CA 5ICNB 5DC8A 4LY1A 3MAXA 3EZPA 5EEMA 5D1BA 4BZ6A 3Q9BA 4BZ5A 4BZ8A 4BZ7A 4RN1A 1C3SA 3C10A 3ZNRA 4QA6A 2VQOA 1ZZ0A 5D1CA 5G0YA 5G0IA 5THVA 5G12A 3EZTA 4ZUOA 2VQQA 1T69A 4QA2A 4ZUQA 5A2SA 5EEIA 4LXZA 3C0ZA 3SFFA 2VQMA 5EF7A 5G1BA 5LI3A 4RN0A 5EEKA 3C0YA 4ZUMA 5IWGA 5G1AA 5EFHA 1ZZ1A 3EW8A 5EFBD 5BWZA 4QA4A 2VQVA 3F06A 3Q9FA 5G11A 5G0GA 4QA5A 5FUEA 5IX0A 5EFGA 3Q9EA 5EFJD 5THSA 3MZ3A 5EENA 5G3WA 2GH6A 1T67A 3MZ6A 5EEFA 5EF8A 4A69A 5EFKB 1W22A 4ZURA 5D1DA 4CBYA 4CBTA 5THTA 5DC6A 5FCWA 4QA3A 3MENA 4QA0A 4ZUPA 4QA1A 3MZ4A 5JI5A 5EFNA 2VCGA 4QA7A 5G10A 4ZUNA 1C3PA 2V5XA 1T64A 5G13A 1VKGA 2V5WA 1C3RA 1ZZ3A 5G0JA 2VQJA 5DC7A 5G1CA 3SFHA 3F07A 5G0HA 5G17A 5G0XA 3EWFA 4RN2A 3F0RA 2VQWG 3MZ7A 3ZNSA 3RQDA 4BKXB 4BZ9A 5THUA 5DC5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CQF A;  3Q9C A;  5ICN B;  5DC8 A;  4LY1 A;  3MAX A;  3EZP A;  5EEM A;  5D1B A;  4BZ6 A;  3Q9B A;  4BZ5 A;  4BZ8 A;  4BZ7 A;  4RN1 A;  1C3S A;  3C10 A;  3ZNR A;  4QA6 A;  2VQO A;  1ZZ0 A;  5D1C A;  5G0Y A;  5G0I A;  5THV A;  5G12 A;  3EZT A;  4ZUO A;  2VQQ A;  1T69 A;  4QA2 A;  4ZUQ A;  5A2S A;  5EEI A;  4LXZ A;  3C0Z A;  3SFF A;  2VQM A;  5EF7 A;  5G1B A;  5LI3 A;  4RN0 A;  5EEK A;  3C0Y A;  4ZUM A;  5IWG A;  5G1A A;  5EFH A;  1ZZ1 A;  3EW8 A;  5EFB D;  5BWZ A;  4QA4 A;  2VQV A;  3F06 A;  3Q9F A;  5G11 A;  5G0G A;  4QA5 A;  5FUE A;  5IX0 A;  5EFG A;  3Q9E A;  5EFJ D;  5THS A;  3MZ3 A;  5EEN A;  5G3W A;  2GH6 A;  1T67 A;  3MZ6 A;  5EEF A;  5EF8 A;  4A69 A;  5EFK B;  1W22 A;  4ZUR A;  5D1D A;  4CBY A;  4CBT A;  5THT A;  5DC6 A;  5FCW A;  4QA3 A;  3MEN A;  4QA0 A;  4ZUP A;  4QA1 A;  3MZ4 A;  5JI5 A;  5EFN A;  2VCG A;  4QA7 A;  5G10 A;  4ZUN A;  1C3P A;  2V5X A;  1T64 A;  5G13 A;  1VKG A;  2V5W A;  1C3R A;  1ZZ3 A;  5G0J A;  2VQJ A;  5DC7 A;  5G1C A;  3SFH A;  3F07 A;  5G0H A;  5G17 A;  5G0X A;  3EWF A;  4RN2 A;  3F0R A;  2VQW G;  3MZ7 A;  3ZNS A;  3RQD A;  4BKX B;  4BZ9 A;  5THU A;  5DC5 A; 
#chains in the Genus database with same CATH topology
 3NIO A;  4RHI A;  4CQF A;  2EF4 A;  3Q9C A;  5DC8 A;  5ICN B;  4LY1 A;  4Q3V A;  3MAX A;  3LP7 A;  2AEB A;  4Q3Q A;  3GMZ A;  3EZP A;  3NIP A;  5EEM A;  1TBJ A;  5D1B A;  3LP4 A;  4BZ6 A;  3Q9B A;  4BZ5 A;  4HWW A;  4GSZ A;  4BZ8 A;  3E9B A;  4MYF A;  3MFW A;  4GSM A;  4RN1 A;  4BZ7 A;  4CEV A;  1C3S A;  3C10 A;  4Q3S A;  4Q40 A;  3ZNR A;  4QA6 A;  1XFK A;  2VQO A;  1ZZ0 A;  5D1C A;  4Q42 A;  5G0Y A;  5G0I A;  5THV A;  4DZ4 A;  4IE2 A;  3TF3 A;  5G12 A;  1TBL A;  4RHQ A;  3EZT A;  4Q3R A;  4ITY A;  4ZUO A;  2VQQ A;  1T69 A;  4QA2 A;  4ZUQ A;  1RLA A;  5EEI A;  5A2S A;  3MFV A;  4LXZ A;  3C0Z A;  4MYL A;  3SFF A;  3SJT A;  4GSV A;  2VQM A;  5EF7 A;  1P8M A;  1WOI A;  1WOH A;  5G1B A;  5LI3 A;  1TA1 A;  1D3V A;  3PZL A;  4RN0 A;  3THJ A;  1T4P A;  4FCK A;  4Q3P A;  5EEK A;  5RLA A;  3C0Y A;  4IXU A;  4ZUM A;  4RHJ A;  3GN0 A;  5IWG A;  5G1A A;  5EFH A;  1HQH A;  1WVA A;  1ZZ1 A;  1WOG A;  1ZPG A;  2RLA A;  3EW8 A;  3CEV A;  4Q3T A;  5EFB D;  5BWZ A;  4Q3R C;  2CEV A;  1WVB A;  4QA4 A;  2VQV A;  1P8N A;  3F06 A;  2EF5 A;  4Q41 A;  1HQG A;  4IU5 A;  3Q9F A;  4RLA A;  3TH7 A;  5G11 A;  3MMR A;  4HXQ A;  4IE3 A;  5G0G A;  4QA5 A;  3RLA A;  5FUE A;  1HQF A;  1P8P A;  1HQ5 A;  5IX0 A;  4GWC A;  5EFG A;  1P8O A;  3F80 A;  3Q9E A;  1T5F A;  2ZAV A;  2PHA A;  5EFJ D;  5THS A;  1T5G A;  3MZ3 A;  5EEN A;  3LHL A;  1T4T A;  5G3W A;  2GH6 A;  1T67 A;  3MZ6 A;  5EEF A;  5EF8 A;  4A69 A;  1T4R A;  5EFK B;  1W22 A;  1TBH A;  2PLL A;  4ZUR A;  5D1D A;  4CBY A;  3E8Q A;  4CBT A;  4HZE A;  1P8Q A;  4MXR A;  5THT A;  2A0M A;  4G3H A;  5DC6 A;  4FCI A;  3SL1 A;  1ZPE A;  5FCW A;  3KV2 A;  3THH A;  4QA3 A;  3MEN A;  4QA0 A;  4ZUP A;  4MYK A;  4QA1 A;  1T4S A;  5HJ9 A;  4I06 A;  3NIQ A;  3MZ4 A;  4IU1 A;  1P8R A;  4RHM A;  3THE A;  1HQX A;  3MJL A;  3SKK A;  5JI5 A;  4GWD A;  5EFN A;  2VCG A;  4Q3U A;  3M1R A;  4QA7 A;  5G10 A;  4ZUN A;  1C3P A;  2V5X A;  1T64 A;  5G13 A;  1GQ7 A;  1VKG A;  2V5W A;  1C3R A;  1ZZ3 A;  4IU0 A;  2VQJ A;  5G0J A;  2PHO A;  5HJA A;  1P8S A;  3E8Z A;  4IE1 A;  3DJ8 A;  5DC7 A;  1GQ6 A;  2EIV A;  5G1C A;  4RHK A;  3SFH A;  4MYN A;  3F07 A;  4IXV A;  3E6K A;  5G0H A;  5G0X A;  5G17 A;  1CEV A;  3EWF A;  4RN2 A;  4IU4 A;  3F0R A;  2VQW G;  5CEV A;  3MZ7 A;  1PQ3 A;  3SL0 A;  3ZNS A;  3E6V A;  3RQD A;  4BKX B;  4BZ9 A;  4RHL A;  5THU A;  1R1O A;  5DC5 A; 
#chains in the Genus database with same CATH homology
 4CQF A;  3Q9C A;  5ICN B;  5DC8 A;  4LY1 A;  3MAX A;  3EZP A;  5EEM A;  5D1B A;  4BZ6 A;  3Q9B A;  4BZ5 A;  4BZ8 A;  4BZ7 A;  4RN1 A;  1C3S A;  3C10 A;  3ZNR A;  4QA6 A;  2VQO A;  1ZZ0 A;  5D1C A;  5G0Y A;  5G0I A;  5THV A;  5G12 A;  3EZT A;  4ZUO A;  2VQQ A;  1T69 A;  4QA2 A;  4ZUQ A;  5A2S A;  5EEI A;  4LXZ A;  3C0Z A;  3SFF A;  2VQM A;  5EF7 A;  5G1B A;  5LI3 A;  4RN0 A;  5EEK A;  3C0Y A;  4ZUM A;  5IWG A;  5G1A A;  5EFH A;  1ZZ1 A;  3EW8 A;  5EFB D;  5BWZ A;  4QA4 A;  2VQV A;  3F06 A;  3Q9F A;  5G11 A;  5G0G A;  4QA5 A;  5FUE A;  5IX0 A;  5EFG A;  3Q9E A;  5EFJ D;  5THS A;  3MZ3 A;  5EEN A;  5G3W A;  2GH6 A;  1T67 A;  3MZ6 A;  5EEF A;  5EF8 A;  4A69 A;  5EFK B;  1W22 A;  4ZUR A;  5D1D A;  4CBY A;  4CBT A;  5THT A;  5DC6 A;  5FCW A;  4QA3 A;  3MEN A;  4QA0 A;  4ZUP A;  4QA1 A;  3MZ4 A;  5JI5 A;  5EFN A;  2VCG A;  4QA7 A;  5G10 A;  4ZUN A;  1C3P A;  2V5X A;  1T64 A;  5G13 A;  1VKG A;  2V5W A;  1C3R A;  1ZZ3 A;  5G0J A;  2VQJ A;  5DC7 A;  5G1C A;  3SFH A;  3F07 A;  5G0H A;  5G17 A;  5G0X A;  3EWF A;  4RN2 A;  3F0R A;  2VQW G;  3MZ7 A;  3ZNS A;  3RQD A;  4BKX B;  4BZ9 A;  5THU A;  5DC5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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