5EEKA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with trichostatin a
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
358
structure length
356
Chain Sequence
SPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 145
structure length 356
sequence length 358
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5eekA00
2VQJA 5DC5A 3Q9CA 3SFFA 1T64A 2VCGA 3C0YA 5THUA 5THTA 5G0HA 4BZ6A 2VQWG 5IX0A 5G0IA 5G1CA 4ZUQA 4QA0A 3ZNSA 5G0JA 3SFHA 4RN2A 1C3RA 5DC7A 3EW8A 2VQMA 5EFNA 5G1BA 4RN0A 5G1AA 4ZUOA 4CQFA 4BZ5A 5EEKA 5EFBD 4BZ9A 4ZUNA 4QA7A 4ZUMA 3MZ7A 4BZ8A 5G3WA 3EZPA 4LXZA 1W22A 2VQOA 4ZURA 5THVA 3MZ6A 3EZTA 4LY1A 3F0RA 3ZNRA 5ICNB 5EEMA 4QA3A 1ZZ3A 3F07A 5G13A 5D1BA 3RQDA 5G0YA 4BZ7A 4QA1A 1ZZ1A 4QA4A 5D1CA 3Q9FA 5G0XA 5JI5A 5EEFA 3MAXA 2VQQA 3Q9BA 5EFHA 5DC6A 5G11A 5G0GA 2V5XA 5A2SA 4QA2A 5EFGA 1C3PA 4CBYA 3F06A 3MENA 1VKGA 5G10A 4QA5A 4A69A 1ZZ0A 3EWFA 5THSA 5DC8A 4ZUPA 5EEIA 2GH6A 5LI3A 1T69A 5EFJD 5EF7A 5G12A 5G17A 3C0ZA 3Q9EA 4QA6A 4BKXB 5D1DA 4RN1A 5FUEA 3MZ3A 2VQVA 5EFKB 5BWZA 1T67A 2V5WA 3C10A 1C3SA 5IWGA 3MZ4A 5EENA 4CBTA 5EF8A 5FCWA
chains in the Genus database with same CATH superfamily
1GQ7A 1P8SA 4Q3VA 4RHQA 3SKKA 2VQJA 1T4SA 3CEVA 4IU5A 5DC5A 3F80A 3E6KA 1HQGA 3Q9CA 3SFFA 1WOGA 1T64A 1HQ5A 2VCGA 3C0YA 5RLAA 5THUA 3PZLA 5THTA 4FCKA 5G0HA 5HJAA 1WOHA 3LHLA 3NIQA 4IU4A 1T4PA 1HQHA 2VQWG 5IX0A 4BZ6A 1P8PA 5G0IA 1ZPGA 5G1CA 4ZUQA 4QA0A 3ZNSA 4MXRA 4Q3RA 4ITYA 4RN2A 5G0JA 3SFHA 1C3RA 1RLAA 2A0MA 4Q41A 5DC7A 4DZ4A 4Q3SA 3E8ZA 3EW8A 2VQMA 4IU1A 4Q3UA 5EFNA 5G1BA 4RN0A 4I06A 5G1AA 4ZUOA 4CQFA 4BZ5A 5EEKA 1ZPEA 5EFBD 3THEA 4ZUNA 4BZ9A 1P8NA 4Q3TA 2PLLA 4HXQA 4QA7A 4ZUMA 1WOIA 2PHAA 3MZ7A 4RHLA 4BZ8A 5G3WA 3E9BA 3E8QA 4HWWA 3EZPA 4CEVA 4LXZA 1W22A 4MYLA 2VQOA 1HQFA 3TF3A 4ZURA 5THVA 3MZ6A 3EZTA 3LP4A 4LY1A 3SJTA 4G3HA 3GN0A 1P8QA 3F0RA 5A2SA 3LP7A 3ZNRA 1TBLA 5ICNB 5EEMA 1CEVA 4QA3A 1ZZ3A 3F07A 5G13A 5D1BA 3RQDA 5G0YA 4BZ7A 1P8RA 4Q42A 1XFKA 4QA1A 1ZZ1A 4FCIA 4QA4A 5D1CA 4GWCA 3Q9FA 5G0XA 5JI5A 5EEFA 3RLAA 4HZEA 3MAXA 2VQQA 2RLAA 3Q9BA 5EFHA 5DC6A 4GSMA 1R1OA 5G11A 5G0GA 4RHMA 2V5XA 3NIPA 3MMRA 3THHA 4IU0A 1PQ3A 3M1RA 3MFWA 2PHOA 4Q3QA 1C3PA 4QA2A 5EFGA 5HJ9A 4CBYA 4RHKA 1TBJA 3F06A 3KV2A 1WVBA 3MENA 2EIVA 4IXVA 2CEVA 3SL0A 1VKGA 4RLAA 5G10A 2ZAVA 4QA5A 3TH7A 2EF5A 4A69A 1ZZ0A 3DJ8A 3EWFA 4MYNA 4GWDA 4Q3RC 5THSA 1T5FA 1D3VA 3GMZA 5DC8A 4Q3PA 4ZUPA 1HQXA 4MYKA 3NIOA 2GH6A 4Q40A 4RHJA 5EEIA 5LI3A 1T69A 5EFJD 1GQ6A 4IXUA 1WVAA 5EF7A 2EF4A 1T4RA 1TBHA 1T4TA 5G12A 2AEBA 4GSVA 3SL1A 3MFVA 4IE1A 3C0ZA 3E6VA 5G17A 3Q9EA 1TA1A 4QA6A 4IE3A 1T5GA 4BKXB 5D1DA 1P8OA 4RN1A 5FUEA 3MZ3A 2VQVA 5EFKB 5BWZA 1T67A 2V5WA 3MJLA 4GSZA 4RHIA 3C10A 1C3SA 4IE2A 5IWGA 3MZ4A 4MYFA 1P8MA 5EENA 5CEVA 3THJA 4CBTA 5EF8A 5FCWA
chains in the Genus database with same CATH topology
2VQJA 5DC5A 3Q9CA 3SFFA 1T64A 2VCGA 3C0YA 5THUA 5THTA 5G0HA 4BZ6A 2VQWG 5IX0A 5G0IA 5G1CA 4ZUQA 4QA0A 3ZNSA 5G0JA 3SFHA 4RN2A 1C3RA 5DC7A 3EW8A 2VQMA 5EFNA 5G1BA 4RN0A 5G1AA 4ZUOA 4CQFA 4BZ5A 5EEKA 5EFBD 4BZ9A 4ZUNA 4QA7A 4ZUMA 3MZ7A 4BZ8A 5G3WA 3EZPA 4LXZA 1W22A 2VQOA 4ZURA 5THVA 3MZ6A 3EZTA 4LY1A 3F0RA 3ZNRA 5ICNB 5EEMA 4QA3A 1ZZ3A 3F07A 5G13A 5D1BA 3RQDA 5G0YA 4BZ7A 4QA1A 1ZZ1A 4QA4A 5D1CA 3Q9FA 5G0XA 5JI5A 5EEFA 3MAXA 2VQQA 3Q9BA 5EFHA 5DC6A 5G11A 5G0GA 2V5XA 5A2SA 4QA2A 5EFGA 1C3PA 4CBYA 3F06A 3MENA 1VKGA 5G10A 4QA5A 4A69A 1ZZ0A 3EWFA 5THSA 5DC8A 4ZUPA 5EEIA 2GH6A 5LI3A 1T69A 5EFJD 5EF7A 5G12A 5G17A 3C0ZA 3Q9EA 4QA6A 4BKXB 5D1DA 4RN1A 5FUEA 3MZ3A 2VQVA 5EFKB 5BWZA 1T67A 2V5WA 3C10A 1C3SA 5IWGA 3MZ4A 5EENA 4CBTA 5EF8A 5FCWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VQJ A;  5DC5 A;  3Q9C A;  3SFF A;  1T64 A;  2VCG A;  3C0Y A;  5THU A;  5THT A;  5G0H A;  4BZ6 A;  2VQW G;  5IX0 A;  5G0I A;  5G1C A;  4ZUQ A;  4QA0 A;  3ZNS A;  5G0J A;  3SFH A;  4RN2 A;  1C3R A;  5DC7 A;  3EW8 A;  2VQM A;  5EFN A;  5G1B A;  4RN0 A;  5G1A A;  4ZUO A;  4CQF A;  4BZ5 A;  5EEK A;  5EFB D;  4BZ9 A;  4ZUN A;  4QA7 A;  4ZUM A;  3MZ7 A;  4BZ8 A;  5G3W A;  3EZP A;  4LXZ A;  1W22 A;  2VQO A;  4ZUR A;  5THV A;  3MZ6 A;  3EZT A;  4LY1 A;  3F0R A;  3ZNR A;  5ICN B;  5EEM A;  4QA3 A;  1ZZ3 A;  3F07 A;  5G13 A;  5D1B A;  3RQD A;  5G0Y A;  4BZ7 A;  4QA1 A;  1ZZ1 A;  4QA4 A;  5D1C A;  3Q9F A;  5G0X A;  5JI5 A;  5EEF A;  3MAX A;  2VQQ A;  3Q9B A;  5EFH A;  5DC6 A;  5G11 A;  5G0G A;  2V5X A;  5A2S A;  4QA2 A;  5EFG A;  1C3P A;  4CBY A;  3F06 A;  3MEN A;  1VKG A;  5G10 A;  4QA5 A;  4A69 A;  1ZZ0 A;  3EWF A;  5THS A;  5DC8 A;  4ZUP A;  5EEI A;  2GH6 A;  5LI3 A;  1T69 A;  5EFJ D;  5EF7 A;  5G12 A;  5G17 A;  3C0Z A;  3Q9E A;  4QA6 A;  4BKX B;  5D1D A;  4RN1 A;  5FUE A;  3MZ3 A;  2VQV A;  5EFK B;  5BWZ A;  1T67 A;  2V5W A;  3C10 A;  1C3S A;  5IWG A;  3MZ4 A;  5EEN A;  4CBT A;  5EF8 A;  5FCW A; 
#chains in the Genus database with same CATH topology
 1GQ7 A;  1P8S A;  4Q3V A;  4RHQ A;  3SKK A;  2VQJ A;  1T4S A;  3CEV A;  4IU5 A;  5DC5 A;  3F80 A;  3E6K A;  1HQG A;  3Q9C A;  3SFF A;  1WOG A;  1T64 A;  1HQ5 A;  2VCG A;  3C0Y A;  5RLA A;  5THU A;  3PZL A;  5THT A;  4FCK A;  5G0H A;  5HJA A;  1WOH A;  3LHL A;  3NIQ A;  4IU4 A;  1T4P A;  1HQH A;  2VQW G;  5IX0 A;  4BZ6 A;  1P8P A;  5G0I A;  1ZPG A;  5G1C A;  4ZUQ A;  4QA0 A;  3ZNS A;  4MXR A;  4Q3R A;  4ITY A;  4RN2 A;  5G0J A;  3SFH A;  1C3R A;  1RLA A;  2A0M A;  4Q41 A;  5DC7 A;  4DZ4 A;  4Q3S A;  3E8Z A;  3EW8 A;  2VQM A;  4IU1 A;  4Q3U A;  5EFN A;  5G1B A;  4RN0 A;  4I06 A;  5G1A A;  4ZUO A;  4CQF A;  4BZ5 A;  5EEK A;  1ZPE A;  5EFB D;  3THE A;  4ZUN A;  4BZ9 A;  1P8N A;  4Q3T A;  2PLL A;  4HXQ A;  4QA7 A;  4ZUM A;  1WOI A;  2PHA A;  3MZ7 A;  4RHL A;  4BZ8 A;  5G3W A;  3E9B A;  3E8Q A;  4HWW A;  3EZP A;  4CEV A;  4LXZ A;  1W22 A;  4MYL A;  2VQO A;  1HQF A;  3TF3 A;  4ZUR A;  5THV A;  3MZ6 A;  3EZT A;  3LP4 A;  4LY1 A;  3SJT A;  4G3H A;  3GN0 A;  1P8Q A;  3F0R A;  5A2S A;  3LP7 A;  3ZNR A;  1TBL A;  5ICN B;  5EEM A;  1CEV A;  4QA3 A;  1ZZ3 A;  3F07 A;  5G13 A;  5D1B A;  3RQD A;  5G0Y A;  4BZ7 A;  1P8R A;  4Q42 A;  1XFK A;  4QA1 A;  1ZZ1 A;  4FCI A;  4QA4 A;  5D1C A;  4GWC A;  3Q9F A;  5G0X A;  5JI5 A;  5EEF A;  3RLA A;  4HZE A;  3MAX A;  2VQQ A;  2RLA A;  3Q9B A;  5EFH A;  5DC6 A;  4GSM A;  1R1O A;  5G11 A;  5G0G A;  4RHM A;  2V5X A;  3NIP A;  3MMR A;  3THH A;  4IU0 A;  1PQ3 A;  3M1R A;  3MFW A;  2PHO A;  4Q3Q A;  1C3P A;  4QA2 A;  5EFG A;  5HJ9 A;  4CBY A;  4RHK A;  1TBJ A;  3F06 A;  3KV2 A;  1WVB A;  3MEN A;  2EIV A;  4IXV A;  2CEV A;  3SL0 A;  1VKG A;  4RLA A;  5G10 A;  2ZAV A;  4QA5 A;  3TH7 A;  2EF5 A;  4A69 A;  1ZZ0 A;  3DJ8 A;  3EWF A;  4MYN A;  4GWD A;  4Q3R C;  5THS A;  1T5F A;  1D3V A;  3GMZ A;  5DC8 A;  4Q3P A;  4ZUP A;  1HQX A;  4MYK A;  3NIO A;  2GH6 A;  4Q40 A;  4RHJ A;  5EEI A;  5LI3 A;  1T69 A;  5EFJ D;  1GQ6 A;  4IXU A;  1WVA A;  5EF7 A;  2EF4 A;  1T4R A;  1TBH A;  1T4T A;  5G12 A;  2AEB A;  4GSV A;  3SL1 A;  3MFV A;  4IE1 A;  3C0Z A;  3E6V A;  5G17 A;  3Q9E A;  1TA1 A;  4QA6 A;  4IE3 A;  1T5G A;  4BKX B;  5D1D A;  1P8O A;  4RN1 A;  5FUE A;  3MZ3 A;  2VQV A;  5EFK B;  5BWZ A;  1T67 A;  2V5W A;  3MJL A;  4GSZ A;  4RHI A;  3C10 A;  1C3S A;  4IE2 A;  5IWG A;  3MZ4 A;  4MYF A;  1P8M A;  5EEN A;  5CEV A;  3THJ A;  4CBT A;  5EF8 A;  5FCW A; 
#chains in the Genus database with same CATH homology
 2VQJ A;  5DC5 A;  3Q9C A;  3SFF A;  1T64 A;  2VCG A;  3C0Y A;  5THU A;  5THT A;  5G0H A;  4BZ6 A;  2VQW G;  5IX0 A;  5G0I A;  5G1C A;  4ZUQ A;  4QA0 A;  3ZNS A;  5G0J A;  3SFH A;  4RN2 A;  1C3R A;  5DC7 A;  3EW8 A;  2VQM A;  5EFN A;  5G1B A;  4RN0 A;  5G1A A;  4ZUO A;  4CQF A;  4BZ5 A;  5EEK A;  5EFB D;  4BZ9 A;  4ZUN A;  4QA7 A;  4ZUM A;  3MZ7 A;  4BZ8 A;  5G3W A;  3EZP A;  4LXZ A;  1W22 A;  2VQO A;  4ZUR A;  5THV A;  3MZ6 A;  3EZT A;  4LY1 A;  3F0R A;  3ZNR A;  5ICN B;  5EEM A;  4QA3 A;  1ZZ3 A;  3F07 A;  5G13 A;  5D1B A;  3RQD A;  5G0Y A;  4BZ7 A;  4QA1 A;  1ZZ1 A;  4QA4 A;  5D1C A;  3Q9F A;  5G0X A;  5JI5 A;  5EEF A;  3MAX A;  2VQQ A;  3Q9B A;  5EFH A;  5DC6 A;  5G11 A;  5G0G A;  2V5X A;  5A2S A;  4QA2 A;  5EFG A;  1C3P A;  4CBY A;  3F06 A;  3MEN A;  1VKG A;  5G10 A;  4QA5 A;  4A69 A;  1ZZ0 A;  3EWF A;  5THS A;  5DC8 A;  4ZUP A;  5EEI A;  2GH6 A;  5LI3 A;  1T69 A;  5EFJ D;  5EF7 A;  5G12 A;  5G17 A;  3C0Z A;  3Q9E A;  4QA6 A;  4BKX B;  5D1D A;  4RN1 A;  5FUE A;  3MZ3 A;  2VQV A;  5EFK B;  5BWZ A;  1T67 A;  2V5W A;  3C10 A;  1C3S A;  5IWG A;  3MZ4 A;  5EEN A;  4CBT A;  5EF8 A;  5FCW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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