5EEKA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with trichostatin a
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
358
structure length
356
Chain Sequence
b'SPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLLTPLKTSATVSINNVLRAHAPFWSSLR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 145
structure length 356
sequence length 358
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5eekA00
5G3WA 5EFGA 4A69A 1T67A 3SFHA 5THUA 4CQFA 5EFBD 3C10A 5EEFA 4ZUOA 4QA1A 3MZ6A 3ZNSA 5EF7A 5G0YA 5FCWA 3EWFA 5G0GA 4BZ5A 4QA6A 2VQOA 3C0YA 3EW8A 4ZUQA 3MZ3A 3EZTA 5G11A 5G12A 5JI5A 4QA4A 4CBYA 2VQJA 4ZUPA 1ZZ3A 3C0ZA 2V5WA 5G17A 4QA3A 4QA5A 5EEMA 4ZURA 3SFFA 5G0JA 3MZ7A 5DC8A 2VQVA 5G0IA 3RQDA 1C3SA 5DC7A 3Q9CA 1W22A 5EENA 4QA2A 2VQWG 3Q9FA 2VQMA 5DC6A 5DC5A 4BZ6A 5A2SA 5G1AA 5BWZA 4QA7A 4RN1A 3F06A 5D1BA 5EF8A 5EFJD 1T64A 5G1CA 4QA0A 1C3PA 5FUEA 5THVA 2VQQA 5G1BA 4LY1A 4BZ8A 4RN2A 5THTA 4ZUMA 5EFHA 5IWGA 1ZZ0A 3MZ4A 4BKXB 5EEKA 3MENA 3EZPA 3F07A 3F0RA 3ZNRA 5G0HA 3Q9EA 5EFNA 5G0XA 1VKGA 5EEIA 1C3RA 4ZUNA 4CBTA 5ICNB 2GH6A 5G10A 4LXZA 5D1CA 1T69A 5G13A 5EFKB 5LI3A 4BZ7A 2VCGA 4BZ9A 5IX0A 2V5XA 5D1DA 1ZZ1A 5THSA 3MAXA 3Q9BA 4RN0A
chains in the Genus database with same CATH superfamily
4HWWA 5G3WA 3THJA 4IE1A 5EFGA 4I06A 4A69A 3MJLA 1T67A 3SFHA 5THUA 4CQFA 5EFBD 2PHAA 3E9BA 4IU4A 3C10A 5EEFA 4QA1A 4ZUOA 3MZ6A 3ZNSA 5EF7A 4FCIA 5G0YA 4Q41A 1HQXA 5HJAA 1TBLA 3E8QA 5FCWA 2CEVA 4IE3A 4G3HA 1ZPGA 4RHIA 1HQGA 3EWFA 3E6KA 3CEVA 5G0GA 3THEA 3SL0A 4BZ5A 4GWDA 1ZPEA 4QA6A 4RHKA 4CEVA 1T4SA 4Q3PA 2VQOA 3C0YA 3EW8A 2EF4A 1XFKA 1HQ5A 1TA1A 1HQHA 4GWCA 4ZUQA 3E6VA 3F80A 4RHQA 3MZ3A 3NIOA 5G11A 1RLAA 2PHOA 2ZAVA 5G12A 1WOHA 5JI5A 4GSZA 4QA4A 4CBYA 2PLLA 2VQJA 4ZUPA 1ZZ3A 1P8NA 4IXVA 1T4RA 2V5WA 3C0ZA 2EIVA 5G17A 1T5FA 4QA3A 4MYKA 1P8PA 4QA5A 4IU1A 5EEMA 3MFVA 4ZURA 3M1RA 3SFFA 1HQFA 1P8QA 3NIPA 5G0JA 3MZ7A 5DC8A 2VQVA 3LP7A 1WVBA 2RLAA 5G0IA 3RQDA 4Q40A 1C3SA 5DC7A 3Q9CA 1W22A 4RN0A 4Q3UA 3THHA 3GN0A 3TH7A 1WOGA 5EENA 4GSVA 4HXQA 4QA2A 2VQWG 4FCKA 4RHJA 4HZEA 3Q9FA 2VQMA 5DC6A 4Q42A 5DC5A 4BZ6A 5A2SA 5G1AA 5BWZA 1P8MA 1CEVA 4QA7A 4RN1A 2A0MA 3F06A 3LHLA 5D1BA 1T4TA 5EF8A 5EFJD 1T64A 5G1CA 4QA0A 1C3PA 4Q3SA 5FUEA 5THVA 3E8ZA 3RLAA 1WVAA 2VQQA 3DJ8A 4Q3RC 1TBJA 2EF5A 3MMRA 1R1OA 4Q3RA 3SKKA 5CEVA 5G1BA 4LY1A 4BZ8A 1D3VA 4MYFA 4RN2A 5THTA 1TBHA 4IU5A 5EFHA 4ZUMA 1ZZ0A 5IWGA 3MZ4A 5RLAA 3SL1A 4BKXB 3NIQA 5EEKA 3MENA 4ITYA 1P8SA 3EZPA 3F07A 3F0RA 1T4PA 3ZNRA 5G0HA 3Q9EA 3MFWA 5EFNA 4Q3TA 4DZ4A 1P8OA 3SJTA 4Q3VA 5G0XA 3LP4A 1VKGA 5EEIA 4RLAA 3GMZA 1C3RA 5HJ9A 4ZUNA 4IE2A 4CBTA 3KV2A 4GSMA 5ICNB 2GH6A 5G10A 4IU0A 4LXZA 5D1CA 1T5GA 1GQ6A 4Q3QA 1P8RA 2AEBA 1T69A 4RHLA 5G13A 4IXUA 1PQ3A 4MXRA 5EFKB 5LI3A 1WOIA 2VCGA 4MYLA 5IX0A 4BZ7A 4BZ9A 2V5XA 4MYNA 3TF3A 5D1DA 1ZZ1A 3PZLA 3MAXA 5THSA 3Q9BA 4RHMA 1GQ7A 3EZTA
chains in the Genus database with same CATH topology
5G3WA 5EFGA 4A69A 1T67A 3SFHA 5THUA 4CQFA 5EFBD 3C10A 5EEFA 4ZUOA 4QA1A 3MZ6A 3ZNSA 5EF7A 5G0YA 5FCWA 3EWFA 5G0GA 4BZ5A 4QA6A 2VQOA 3C0YA 3EW8A 4ZUQA 3MZ3A 3EZTA 5G11A 5G12A 5JI5A 4QA4A 4CBYA 2VQJA 4ZUPA 1ZZ3A 3C0ZA 2V5WA 5G17A 4QA3A 4QA5A 5EEMA 4ZURA 3SFFA 5G0JA 3MZ7A 5DC8A 2VQVA 5G0IA 3RQDA 1C3SA 5DC7A 3Q9CA 1W22A 5EENA 4QA2A 2VQWG 3Q9FA 2VQMA 5DC6A 5DC5A 4BZ6A 5A2SA 5G1AA 5BWZA 4QA7A 4RN1A 3F06A 5D1BA 5EF8A 5EFJD 1T64A 5G1CA 4QA0A 1C3PA 5FUEA 5THVA 2VQQA 5G1BA 4LY1A 4BZ8A 4RN2A 5THTA 4ZUMA 5EFHA 5IWGA 1ZZ0A 3MZ4A 4BKXB 5EEKA 3MENA 3EZPA 3F07A 3F0RA 3ZNRA 5G0HA 3Q9EA 5EFNA 5G0XA 1VKGA 5EEIA 1C3RA 4ZUNA 4CBTA 5ICNB 2GH6A 5G10A 4LXZA 5D1CA 1T69A 5G13A 5EFKB 5LI3A 4BZ7A 2VCGA 4BZ9A 5IX0A 2V5XA 5D1DA 1ZZ1A 5THSA 3MAXA 3Q9BA 4RN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G3W A;  5EFG A;  4A69 A;  1T67 A;  3SFH A;  5THU A;  4CQF A;  5EFB D;  3C10 A;  5EEF A;  4ZUO A;  4QA1 A;  3MZ6 A;  3ZNS A;  5EF7 A;  5G0Y A;  5FCW A;  3EWF A;  5G0G A;  4BZ5 A;  4QA6 A;  2VQO A;  3C0Y A;  3EW8 A;  4ZUQ A;  3MZ3 A;  3EZT A;  5G11 A;  5G12 A;  5JI5 A;  4QA4 A;  4CBY A;  2VQJ A;  4ZUP A;  1ZZ3 A;  3C0Z A;  2V5W A;  5G17 A;  4QA3 A;  4QA5 A;  5EEM A;  4ZUR A;  3SFF A;  5G0J A;  3MZ7 A;  5DC8 A;  2VQV A;  5G0I A;  3RQD A;  1C3S A;  5DC7 A;  3Q9C A;  1W22 A;  5EEN A;  4QA2 A;  2VQW G;  3Q9F A;  2VQM A;  5DC6 A;  5DC5 A;  4BZ6 A;  5A2S A;  5G1A A;  5BWZ A;  4QA7 A;  4RN1 A;  3F06 A;  5D1B A;  5EF8 A;  5EFJ D;  1T64 A;  5G1C A;  4QA0 A;  1C3P A;  5FUE A;  5THV A;  2VQQ A;  5G1B A;  4LY1 A;  4BZ8 A;  4RN2 A;  5THT A;  4ZUM A;  5EFH A;  5IWG A;  1ZZ0 A;  3MZ4 A;  4BKX B;  5EEK A;  3MEN A;  3EZP A;  3F07 A;  3F0R A;  3ZNR A;  5G0H A;  3Q9E A;  5EFN A;  5G0X A;  1VKG A;  5EEI A;  1C3R A;  4ZUN A;  4CBT A;  5ICN B;  2GH6 A;  5G10 A;  4LXZ A;  5D1C A;  1T69 A;  5G13 A;  5EFK B;  5LI3 A;  4BZ7 A;  2VCG A;  4BZ9 A;  5IX0 A;  2V5X A;  5D1D A;  1ZZ1 A;  5THS A;  3MAX A;  3Q9B A;  4RN0 A; 
#chains in the Genus database with same CATH topology
 4HWW A;  5G3W A;  3THJ A;  4IE1 A;  5EFG A;  4I06 A;  4A69 A;  3MJL A;  1T67 A;  3SFH A;  5THU A;  4CQF A;  5EFB D;  2PHA A;  3E9B A;  4IU4 A;  3C10 A;  5EEF A;  4QA1 A;  4ZUO A;  3MZ6 A;  3ZNS A;  5EF7 A;  4FCI A;  5G0Y A;  4Q41 A;  1HQX A;  5HJA A;  1TBL A;  3E8Q A;  5FCW A;  2CEV A;  4IE3 A;  4G3H A;  1ZPG A;  4RHI A;  1HQG A;  3EWF A;  3E6K A;  3CEV A;  5G0G A;  3THE A;  3SL0 A;  4BZ5 A;  4GWD A;  1ZPE A;  4QA6 A;  4RHK A;  4CEV A;  1T4S A;  4Q3P A;  2VQO A;  3C0Y A;  3EW8 A;  2EF4 A;  1XFK A;  1HQ5 A;  1TA1 A;  1HQH A;  4GWC A;  4ZUQ A;  3E6V A;  3F80 A;  4RHQ A;  3MZ3 A;  3NIO A;  5G11 A;  1RLA A;  2PHO A;  2ZAV A;  5G12 A;  1WOH A;  5JI5 A;  4GSZ A;  4QA4 A;  4CBY A;  2PLL A;  2VQJ A;  4ZUP A;  1ZZ3 A;  1P8N A;  4IXV A;  1T4R A;  2V5W A;  3C0Z A;  2EIV A;  5G17 A;  1T5F A;  4QA3 A;  4MYK A;  1P8P A;  4QA5 A;  4IU1 A;  5EEM A;  3MFV A;  4ZUR A;  3M1R A;  3SFF A;  1HQF A;  1P8Q A;  3NIP A;  5G0J A;  3MZ7 A;  5DC8 A;  2VQV A;  3LP7 A;  1WVB A;  2RLA A;  5G0I A;  3RQD A;  4Q40 A;  1C3S A;  5DC7 A;  3Q9C A;  1W22 A;  4RN0 A;  4Q3U A;  3THH A;  3GN0 A;  3TH7 A;  1WOG A;  5EEN A;  4GSV A;  4HXQ A;  4QA2 A;  2VQW G;  4FCK A;  4RHJ A;  4HZE A;  3Q9F A;  2VQM A;  5DC6 A;  4Q42 A;  5DC5 A;  4BZ6 A;  5A2S A;  5G1A A;  5BWZ A;  1P8M A;  1CEV A;  4QA7 A;  4RN1 A;  2A0M A;  3F06 A;  3LHL A;  5D1B A;  1T4T A;  5EF8 A;  5EFJ D;  1T64 A;  5G1C A;  4QA0 A;  1C3P A;  4Q3S A;  5FUE A;  5THV A;  3E8Z A;  3RLA A;  1WVA A;  2VQQ A;  3DJ8 A;  4Q3R C;  1TBJ A;  2EF5 A;  3MMR A;  1R1O A;  4Q3R A;  3SKK A;  5CEV A;  5G1B A;  4LY1 A;  4BZ8 A;  1D3V A;  4MYF A;  4RN2 A;  5THT A;  1TBH A;  4IU5 A;  5EFH A;  4ZUM A;  1ZZ0 A;  5IWG A;  3MZ4 A;  5RLA A;  3SL1 A;  4BKX B;  3NIQ A;  5EEK A;  3MEN A;  4ITY A;  1P8S A;  3EZP A;  3F07 A;  3F0R A;  1T4P A;  3ZNR A;  5G0H A;  3Q9E A;  3MFW A;  5EFN A;  4Q3T A;  4DZ4 A;  1P8O A;  3SJT A;  4Q3V A;  5G0X A;  3LP4 A;  1VKG A;  5EEI A;  4RLA A;  3GMZ A;  1C3R A;  5HJ9 A;  4ZUN A;  4IE2 A;  4CBT A;  3KV2 A;  4GSM A;  5ICN B;  2GH6 A;  5G10 A;  4IU0 A;  4LXZ A;  5D1C A;  1T5G A;  1GQ6 A;  4Q3Q A;  1P8R A;  2AEB A;  1T69 A;  4RHL A;  5G13 A;  4IXU A;  1PQ3 A;  4MXR A;  5EFK B;  5LI3 A;  1WOI A;  2VCG A;  4MYL A;  5IX0 A;  4BZ7 A;  4BZ9 A;  2V5X A;  4MYN A;  3TF3 A;  5D1D A;  1ZZ1 A;  3PZL A;  3MAX A;  5THS A;  3Q9B A;  4RHM A;  1GQ7 A;  3EZT A; 
#chains in the Genus database with same CATH homology
 5G3W A;  5EFG A;  4A69 A;  1T67 A;  3SFH A;  5THU A;  4CQF A;  5EFB D;  3C10 A;  5EEF A;  4ZUO A;  4QA1 A;  3MZ6 A;  3ZNS A;  5EF7 A;  5G0Y A;  5FCW A;  3EWF A;  5G0G A;  4BZ5 A;  4QA6 A;  2VQO A;  3C0Y A;  3EW8 A;  4ZUQ A;  3MZ3 A;  3EZT A;  5G11 A;  5G12 A;  5JI5 A;  4QA4 A;  4CBY A;  2VQJ A;  4ZUP A;  1ZZ3 A;  3C0Z A;  2V5W A;  5G17 A;  4QA3 A;  4QA5 A;  5EEM A;  4ZUR A;  3SFF A;  5G0J A;  3MZ7 A;  5DC8 A;  2VQV A;  5G0I A;  3RQD A;  1C3S A;  5DC7 A;  3Q9C A;  1W22 A;  5EEN A;  4QA2 A;  2VQW G;  3Q9F A;  2VQM A;  5DC6 A;  5DC5 A;  4BZ6 A;  5A2S A;  5G1A A;  5BWZ A;  4QA7 A;  4RN1 A;  3F06 A;  5D1B A;  5EF8 A;  5EFJ D;  1T64 A;  5G1C A;  4QA0 A;  1C3P A;  5FUE A;  5THV A;  2VQQ A;  5G1B A;  4LY1 A;  4BZ8 A;  4RN2 A;  5THT A;  4ZUM A;  5EFH A;  5IWG A;  1ZZ0 A;  3MZ4 A;  4BKX B;  5EEK A;  3MEN A;  3EZP A;  3F07 A;  3F0R A;  3ZNR A;  5G0H A;  3Q9E A;  5EFN A;  5G0X A;  1VKG A;  5EEI A;  1C3R A;  4ZUN A;  4CBT A;  5ICN B;  2GH6 A;  5G10 A;  4LXZ A;  5D1C A;  1T69 A;  5G13 A;  5EFK B;  5LI3 A;  4BZ7 A;  2VCG A;  4BZ9 A;  5IX0 A;  2V5X A;  5D1D A;  1ZZ1 A;  5THS A;  3MAX A;  3Q9B A;  4RN0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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