5EEIA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with saha
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
357
structure length
357
Chain Sequence
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 137
structure length 357
sequence length 357
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5eeiA00
4QA4A 5EENA 5EFGA 5D1BA 5G0GA 4QA7A 5G1CA 5DC6A 4QA3A 5IX0A 5G0JA 1T67A 3MZ6A 5EFJD 5G3WA 3EWFA 4A69A 5BWZA 3C10A 5EFBD 3MAXA 5EF8A 4BZ8A 3ZNSA 3MZ3A 3Q9CA 2V5WA 3EW8A 4CBYA 5A2SA 2VQJA 5EEIA 4ZUPA 5G0IA 5DC5A 3C0ZA 4LXZA 1W22A 3RQDA 5EFHA 4QA5A 4ZUOA 5EFKB 1VKGA 1ZZ0A 2V5XA 4BKXB 5THTA 5JI5A 5EFNA 4QA6A 4QA0A 5EEFA 3Q9BA 5G0HA 5G12A 4CBTA 4BZ7A 5EEMA 2VQOA 3ZNRA 5EF7A 2VCGA 4QA1A 5DC8A 4RN1A 5G0YA 5LI3A 1T69A 3F07A 4ZUMA 4LY1A 5D1DA 3Q9FA 4BZ9A 5FCWA 5G17A 5ICNB 5G13A 4CQFA 3F06A 3MZ7A 3EZPA 1ZZ1A 5DC7A 2VQQA 1T64A 2VQMA 3SFFA 3MZ4A 3MENA 2VQVA 1C3SA 5EEKA 5G1AA 1ZZ3A 2VQWG 4QA2A 5THVA 4ZUQA 5THSA 5THUA 5G11A 3SFHA 3F0RA 1C3RA 5IWGA 4ZURA 5G0XA 5FUEA 2GH6A 4BZ5A 4BZ6A 3C0YA 3EZTA 5G1BA 5D1CA 5G10A 1C3PA 4ZUNA 3Q9EA 4RN0A 4RN2A
chains in the Genus database with same CATH superfamily
4GWDA 4QA4A 4RHKA 3MMRA 1P8PA 2EF5A 5EENA 4RHJA 5EFGA 4MXRA 4MYFA 1T5FA 5D1BA 1TBHA 5G0GA 1P8NA 3NIPA 4QA7A 5G1CA 2A0MA 1T4RA 4GSZA 5DC6A 4G3HA 4QA3A 3MJLA 5IX0A 5G0JA 4CEVA 1T67A 1T4PA 2EIVA 3MZ6A 5EFJD 5G3WA 1XFKA 3EWFA 3F80A 4A69A 4MYNA 4Q3TA 3LHLA 5BWZA 3C10A 1HQHA 1P8SA 5EFBD 3MAXA 1HQXA 1HQFA 1TBJA 4GWCA 5EF8A 4BZ8A 4IE1A 1P8OA 3MZ3A 3Q9CA 3E6VA 3NIQA 3M1RA 2V5WA 4Q3RC 3ZNSA 3EW8A 4CBYA 5HJ9A 1TBLA 5A2SA 2VQJA 1CEVA 5EEIA 4ZUPA 2EF4A 4FCKA 5G0IA 3TF3A 4RHIA 5DC5A 3C0ZA 3RLAA 4LXZA 1W22A 3MFWA 1D3VA 4Q3RA 4QA5A 4RLAA 5EFHA 4ZUOA 3RQDA 5EFKB 1VKGA 1ZZ0A 4DZ4A 5CEVA 2V5XA 3KV2A 4Q3PA 4BKXB 4MYLA 5THTA 5JI5A 1GQ7A 4RHQA 5EFNA 2ZAVA 4GSVA 4IU4A 1WOIA 4QA6A 3THEA 4Q41A 1RLAA 4QA0A 3THJA 1T4SA 4Q42A 5EEFA 3Q9BA 4FCIA 5G0HA 1WOHA 5G12A 4Q40A 5RLAA 4CBTA 3SKKA 1R1OA 4BZ7A 4HWWA 4IE3A 5EEMA 1ZPGA 2PHOA 2VQOA 3NIOA 3ZNRA 3SJTA 5EF7A 3SL0A 1TA1A 2VCGA 4Q3VA 3E8QA 4QA1A 1T5GA 5DC8A 1WVBA 4RN1A 4Q3SA 5G0YA 5LI3A 4IXVA 4MYKA 1T69A 3F07A 4ZUMA 4LY1A 5D1DA 3Q9FA 4BZ9A 5FCWA 4I06A 1T4TA 4RHLA 5G17A 1P8MA 2AEBA 5G13A 4CQFA 5ICNB 4GSMA 3F06A 1ZPEA 4HXQA 3SL1A 3MZ7A 3EZPA 3E8ZA 3LP7A 4IU5A 1ZZ1A 5DC7A 1WOGA 2VQQA 1T64A 2VQMA 3SFFA 3MZ4A 3MENA 2PHAA 3GMZA 2VQVA 2RLAA 4IU0A 1C3SA 5EEKA 5G1AA 1ZZ3A 2VQWG 4QA2A 4RHMA 3MFVA 5THVA 4ZUQA 5THSA 4ITYA 3E6KA 5THUA 3TH7A 5G11A 3SFHA 3THHA 3F0RA 1C3RA 4HZEA 5IWGA 1WVAA 3GN0A 4IE2A 1P8RA 4Q3QA 4ZURA 5FUEA 2GH6A 5G0XA 4IU1A 4BZ5A 4BZ6A 3E9BA 1PQ3A 1HQGA 3LP4A 1P8QA 3C0YA 3EZTA 4IXUA 1GQ6A 1HQ5A 3CEVA 5G1BA 5D1CA 3PZLA 5G10A 1C3PA 4ZUNA 5HJAA 3Q9EA 4Q3UA 4RN0A 2CEVA 4RN2A 3DJ8A 2PLLA
chains in the Genus database with same CATH topology
4QA4A 5EENA 5EFGA 5D1BA 5G0GA 4QA7A 5G1CA 5DC6A 4QA3A 5IX0A 5G0JA 1T67A 3MZ6A 5EFJD 5G3WA 3EWFA 4A69A 5BWZA 3C10A 5EFBD 3MAXA 5EF8A 4BZ8A 3ZNSA 3MZ3A 3Q9CA 2V5WA 3EW8A 4CBYA 5A2SA 2VQJA 5EEIA 4ZUPA 5G0IA 5DC5A 3C0ZA 4LXZA 1W22A 3RQDA 5EFHA 4QA5A 4ZUOA 5EFKB 1VKGA 1ZZ0A 2V5XA 4BKXB 5THTA 5JI5A 5EFNA 4QA6A 4QA0A 5EEFA 3Q9BA 5G0HA 5G12A 4CBTA 4BZ7A 5EEMA 2VQOA 3ZNRA 5EF7A 2VCGA 4QA1A 5DC8A 4RN1A 5G0YA 5LI3A 1T69A 3F07A 4ZUMA 4LY1A 5D1DA 3Q9FA 4BZ9A 5FCWA 5G17A 5ICNB 5G13A 4CQFA 3F06A 3MZ7A 3EZPA 1ZZ1A 5DC7A 2VQQA 1T64A 2VQMA 3SFFA 3MZ4A 3MENA 2VQVA 1C3SA 5EEKA 5G1AA 1ZZ3A 2VQWG 4QA2A 5THVA 4ZUQA 5THSA 5THUA 5G11A 3SFHA 3F0RA 1C3RA 5IWGA 4ZURA 5G0XA 5FUEA 2GH6A 4BZ5A 4BZ6A 3C0YA 3EZTA 5G1BA 5D1CA 5G10A 1C3PA 4ZUNA 3Q9EA 4RN0A 4RN2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QA4 A;  5EEN A;  5EFG A;  5D1B A;  5G0G A;  4QA7 A;  5G1C A;  5DC6 A;  4QA3 A;  5IX0 A;  5G0J A;  1T67 A;  3MZ6 A;  5EFJ D;  5G3W A;  3EWF A;  4A69 A;  5BWZ A;  3C10 A;  5EFB D;  3MAX A;  5EF8 A;  4BZ8 A;  3ZNS A;  3MZ3 A;  3Q9C A;  2V5W A;  3EW8 A;  4CBY A;  5A2S A;  2VQJ A;  5EEI A;  4ZUP A;  5G0I A;  5DC5 A;  3C0Z A;  4LXZ A;  1W22 A;  3RQD A;  5EFH A;  4QA5 A;  4ZUO A;  5EFK B;  1VKG A;  1ZZ0 A;  2V5X A;  4BKX B;  5THT A;  5JI5 A;  5EFN A;  4QA6 A;  4QA0 A;  5EEF A;  3Q9B A;  5G0H A;  5G12 A;  4CBT A;  4BZ7 A;  5EEM A;  2VQO A;  3ZNR A;  5EF7 A;  2VCG A;  4QA1 A;  5DC8 A;  4RN1 A;  5G0Y A;  5LI3 A;  1T69 A;  3F07 A;  4ZUM A;  4LY1 A;  5D1D A;  3Q9F A;  4BZ9 A;  5FCW A;  5G17 A;  5ICN B;  5G13 A;  4CQF A;  3F06 A;  3MZ7 A;  3EZP A;  1ZZ1 A;  5DC7 A;  2VQQ A;  1T64 A;  2VQM A;  3SFF A;  3MZ4 A;  3MEN A;  2VQV A;  1C3S A;  5EEK A;  5G1A A;  1ZZ3 A;  2VQW G;  4QA2 A;  5THV A;  4ZUQ A;  5THS A;  5THU A;  5G11 A;  3SFH A;  3F0R A;  1C3R A;  5IWG A;  4ZUR A;  5G0X A;  5FUE A;  2GH6 A;  4BZ5 A;  4BZ6 A;  3C0Y A;  3EZT A;  5G1B A;  5D1C A;  5G10 A;  1C3P A;  4ZUN A;  3Q9E A;  4RN0 A;  4RN2 A; 
#chains in the Genus database with same CATH topology
 4GWD A;  4QA4 A;  4RHK A;  3MMR A;  1P8P A;  2EF5 A;  5EEN A;  4RHJ A;  5EFG A;  4MXR A;  4MYF A;  1T5F A;  5D1B A;  1TBH A;  5G0G A;  1P8N A;  3NIP A;  4QA7 A;  5G1C A;  2A0M A;  1T4R A;  4GSZ A;  5DC6 A;  4G3H A;  4QA3 A;  3MJL A;  5IX0 A;  5G0J A;  4CEV A;  1T67 A;  1T4P A;  2EIV A;  3MZ6 A;  5EFJ D;  5G3W A;  1XFK A;  3EWF A;  3F80 A;  4A69 A;  4MYN A;  4Q3T A;  3LHL A;  5BWZ A;  3C10 A;  1HQH A;  1P8S A;  5EFB D;  3MAX A;  1HQX A;  1HQF A;  1TBJ A;  4GWC A;  5EF8 A;  4BZ8 A;  4IE1 A;  1P8O A;  3MZ3 A;  3Q9C A;  3E6V A;  3NIQ A;  3M1R A;  2V5W A;  4Q3R C;  3ZNS A;  3EW8 A;  4CBY A;  5HJ9 A;  1TBL A;  5A2S A;  2VQJ A;  1CEV A;  5EEI A;  4ZUP A;  2EF4 A;  4FCK A;  5G0I A;  3TF3 A;  4RHI A;  5DC5 A;  3C0Z A;  3RLA A;  4LXZ A;  1W22 A;  3MFW A;  1D3V A;  4Q3R A;  4QA5 A;  4RLA A;  5EFH A;  4ZUO A;  3RQD A;  5EFK B;  1VKG A;  1ZZ0 A;  4DZ4 A;  5CEV A;  2V5X A;  3KV2 A;  4Q3P A;  4BKX B;  4MYL A;  5THT A;  5JI5 A;  1GQ7 A;  4RHQ A;  5EFN A;  2ZAV A;  4GSV A;  4IU4 A;  1WOI A;  4QA6 A;  3THE A;  4Q41 A;  1RLA A;  4QA0 A;  3THJ A;  1T4S A;  4Q42 A;  5EEF A;  3Q9B A;  4FCI A;  5G0H A;  1WOH A;  5G12 A;  4Q40 A;  5RLA A;  4CBT A;  3SKK A;  1R1O A;  4BZ7 A;  4HWW A;  4IE3 A;  5EEM A;  1ZPG A;  2PHO A;  2VQO A;  3NIO A;  3ZNR A;  3SJT A;  5EF7 A;  3SL0 A;  1TA1 A;  2VCG A;  4Q3V A;  3E8Q A;  4QA1 A;  1T5G A;  5DC8 A;  1WVB A;  4RN1 A;  4Q3S A;  5G0Y A;  5LI3 A;  4IXV A;  4MYK A;  1T69 A;  3F07 A;  4ZUM A;  4LY1 A;  5D1D A;  3Q9F A;  4BZ9 A;  5FCW A;  4I06 A;  1T4T A;  4RHL A;  5G17 A;  1P8M A;  2AEB A;  5G13 A;  4CQF A;  5ICN B;  4GSM A;  3F06 A;  1ZPE A;  4HXQ A;  3SL1 A;  3MZ7 A;  3EZP A;  3E8Z A;  3LP7 A;  4IU5 A;  1ZZ1 A;  5DC7 A;  1WOG A;  2VQQ A;  1T64 A;  2VQM A;  3SFF A;  3MZ4 A;  3MEN A;  2PHA A;  3GMZ A;  2VQV A;  2RLA A;  4IU0 A;  1C3S A;  5EEK A;  5G1A A;  1ZZ3 A;  2VQW G;  4QA2 A;  4RHM A;  3MFV A;  5THV A;  4ZUQ A;  5THS A;  4ITY A;  3E6K A;  5THU A;  3TH7 A;  5G11 A;  3SFH A;  3THH A;  3F0R A;  1C3R A;  4HZE A;  5IWG A;  1WVA A;  3GN0 A;  4IE2 A;  1P8R A;  4Q3Q A;  4ZUR A;  5FUE A;  2GH6 A;  5G0X A;  4IU1 A;  4BZ5 A;  4BZ6 A;  3E9B A;  1PQ3 A;  1HQG A;  3LP4 A;  1P8Q A;  3C0Y A;  3EZT A;  4IXU A;  1GQ6 A;  1HQ5 A;  3CEV A;  5G1B A;  5D1C A;  3PZL A;  5G10 A;  1C3P A;  4ZUN A;  5HJA A;  3Q9E A;  4Q3U A;  4RN0 A;  2CEV A;  4RN2 A;  3DJ8 A;  2PLL A; 
#chains in the Genus database with same CATH homology
 4QA4 A;  5EEN A;  5EFG A;  5D1B A;  5G0G A;  4QA7 A;  5G1C A;  5DC6 A;  4QA3 A;  5IX0 A;  5G0J A;  1T67 A;  3MZ6 A;  5EFJ D;  5G3W A;  3EWF A;  4A69 A;  5BWZ A;  3C10 A;  5EFB D;  3MAX A;  5EF8 A;  4BZ8 A;  3ZNS A;  3MZ3 A;  3Q9C A;  2V5W A;  3EW8 A;  4CBY A;  5A2S A;  2VQJ A;  5EEI A;  4ZUP A;  5G0I A;  5DC5 A;  3C0Z A;  4LXZ A;  1W22 A;  3RQD A;  5EFH A;  4QA5 A;  4ZUO A;  5EFK B;  1VKG A;  1ZZ0 A;  2V5X A;  4BKX B;  5THT A;  5JI5 A;  5EFN A;  4QA6 A;  4QA0 A;  5EEF A;  3Q9B A;  5G0H A;  5G12 A;  4CBT A;  4BZ7 A;  5EEM A;  2VQO A;  3ZNR A;  5EF7 A;  2VCG A;  4QA1 A;  5DC8 A;  4RN1 A;  5G0Y A;  5LI3 A;  1T69 A;  3F07 A;  4ZUM A;  4LY1 A;  5D1D A;  3Q9F A;  4BZ9 A;  5FCW A;  5G17 A;  5ICN B;  5G13 A;  4CQF A;  3F06 A;  3MZ7 A;  3EZP A;  1ZZ1 A;  5DC7 A;  2VQQ A;  1T64 A;  2VQM A;  3SFF A;  3MZ4 A;  3MEN A;  2VQV A;  1C3S A;  5EEK A;  5G1A A;  1ZZ3 A;  2VQW G;  4QA2 A;  5THV A;  4ZUQ A;  5THS A;  5THU A;  5G11 A;  3SFH A;  3F0R A;  1C3R A;  5IWG A;  4ZUR A;  5G0X A;  5FUE A;  2GH6 A;  4BZ5 A;  4BZ6 A;  3C0Y A;  3EZT A;  5G1B A;  5D1C A;  5G10 A;  1C3P A;  4ZUN A;  3Q9E A;  4RN0 A;  4RN2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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