5EFHA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
356
structure length
356
Chain Sequence
ITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 141
structure length 356
sequence length 356
chains with identical sequence D
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5efhA00
5THVA 3ZNSA 5G11A 4QA1A 4BZ7A 1W22A 5FCWA 4QA3A 3MZ3A 2VQVA 3RQDA 4RN0A 5EEFA 5EF8A 3C0ZA 4QA6A 2GH6A 3F07A 5G17A 3MZ6A 3Q9EA 5THTA 4LY1A 5D1BA 4ZUQA 1C3PA 5G3WA 4QA4A 5EEIA 1C3SA 4ZUOA 2VQQA 3MZ7A 4BZ6A 4CQFA 5A2SA 5EENA 2VQOA 4ZUMA 3Q9FA 5G1CA 3MZ4A 1T64A 3SFHA 4QA2A 5G12A 4A69A 5IX0A 1T67A 4QA5A 5EF7A 5G1AA 5EFBD 5EEMA 5LI3A 5EFGA 4BZ8A 5ICNB 3C0YA 3EZPA 3C10A 4QA0A 3Q9CA 3MENA 1VKGA 5EFKB 2VQWG 3SFFA 3F06A 5G0XA 4RN2A 3EZTA 4ZURA 5EFHA 4ZUPA 5THUA 5DC6A 3F0RA 2VCGA 5DC8A 1ZZ0A 1ZZ3A 2V5WA 5G0JA 4RN1A 5DC5A 1ZZ1A 1C3RA 3MAXA 4CBYA 5G1BA 4BZ9A 5JI5A 5G13A 5IWGA 4LXZA 4CBTA 5D1DA 5D1CA 4ZUNA 4BKXB 3EW8A 3Q9BA 5EFNA 2VQMA 2VQJA 4QA7A 3EWFA 5FUEA 5DC7A 5EFJD 5G0YA 3ZNRA 2V5XA 5G0IA 5BWZA 5G0GA 1T69A 4BZ5A 5G0HA 5G10A 5THSA 5EEKA
chains in the Genus database with same CATH superfamily
1T5FA 3F80A 5THVA 3ZNSA 5G11A 4QA1A 4BZ7A 1GQ6A 1T4SA 1CEVA 1WVBA 5CEVA 1HQHA 1W22A 5FCWA 4QA3A 4IU5A 4RHKA 4MYKA 5RLAA 3MZ3A 2VQVA 4MYNA 3RQDA 4RN0A 5EEFA 4IE3A 5EF8A 3C0ZA 4QA6A 2GH6A 3F07A 5G17A 4RHMA 3MZ6A 4HZEA 3Q9EA 5THTA 1HQXA 4LY1A 4RHQA 3E6KA 5D1BA 2RLAA 4ZUQA 1C3PA 2ZAVA 5G3WA 4QA4A 5EEIA 3THJA 1C3SA 4GSZA 2VQQA 3MZ7A 1TBJA 4ZUOA 2EF5A 3GMZA 4BZ6A 4CQFA 5A2SA 5EENA 2VQOA 4ZUMA 3Q9FA 5G1CA 3MZ4A 1T64A 4Q3UA 3SFHA 4IE1A 1P8OA 4IXVA 4QA2A 1P8RA 1HQGA 1R1OA 4HWWA 4Q3RA 5G12A 4CEVA 1WOGA 4A69A 1HQ5A 5IX0A 1T67A 4Q41A 4GSMA 4QA5A 5EF7A 2EF4A 5HJ9A 5G1AA 5EFBD 3E9BA 5EEMA 5LI3A 4HXQA 5EFGA 4BZ8A 2AEBA 4RLAA 5ICNB 3THHA 4Q40A 3MFVA 4IU0A 4I06A 3C0YA 1T4PA 1P8MA 1HQFA 4Q3SA 1P8PA 3EZPA 3C10A 2PLLA 4QA0A 3LHLA 3Q9CA 4DZ4A 3MENA 1VKGA 5EFKB 2VQWG 3SFFA 3F06A 1WVAA 4IU4A 1TA1A 4Q3PA 3KV2A 1WOIA 4RHJA 5G0XA 1P8QA 3NIOA 4Q42A 4RN2A 3SKKA 3EZTA 4GSVA 4ZURA 5EFHA 1WOHA 2PHOA 5DC6A 3F0RA 2VCGA 5DC8A 4ZUPA 1ZZ0A 3MMRA 5THUA 1ZZ3A 2V5WA 3NIPA 4IXUA 4RN1A 1ZZ1A 1C3RA 3MAXA 5DC5A 5G0JA 4CBYA 5G1BA 2CEVA 3PZLA 4RHIA 2PHAA 1T4RA 3LP4A 4BZ9A 1P8SA 1P8NA 5G13A 4MXRA 5IWGA 4LXZA 3CEVA 1PQ3A 3SL0A 5JI5A 3MFWA 4Q3RC 1TBHA 3E8QA 3MJLA 4CBTA 1T4TA 4Q3VA 5D1DA 5D1CA 1RLAA 4ZUNA 4RHLA 4BKXB 3E8ZA 3EW8A 3RLAA 3THEA 3TH7A 3NIQA 1ZPGA 3DJ8A 4Q3TA 3Q9BA 5EFNA 3E6VA 4GWCA 2VQMA 3GN0A 4ITYA 4IE2A 3SJTA 3SL1A 3M1RA 2VQJA 1GQ7A 1D3VA 4GWDA 4IU1A 4QA7A 3EWFA 5FUEA 5DC7A 2A0MA 5EFJD 1ZPEA 5G0YA 3ZNRA 2V5XA 1TBLA 4MYFA 5G0IA 4FCIA 5BWZA 4G3HA 1T5GA 5G0GA 3LP7A 1T69A 4BZ5A 5G0HA 4FCKA 4MYLA 5G10A 5THSA 4Q3QA 5HJAA 2EIVA 1XFKA 5EEKA 3TF3A
chains in the Genus database with same CATH topology
5THVA 3ZNSA 5G11A 4QA1A 4BZ7A 1W22A 5FCWA 4QA3A 3MZ3A 2VQVA 3RQDA 4RN0A 5EEFA 5EF8A 3C0ZA 4QA6A 2GH6A 3F07A 5G17A 3MZ6A 3Q9EA 5THTA 4LY1A 5D1BA 4ZUQA 1C3PA 5G3WA 4QA4A 5EEIA 1C3SA 4ZUOA 2VQQA 3MZ7A 4BZ6A 4CQFA 5A2SA 5EENA 2VQOA 4ZUMA 3Q9FA 5G1CA 3MZ4A 1T64A 3SFHA 4QA2A 5G12A 4A69A 5IX0A 1T67A 4QA5A 5EF7A 5G1AA 5EFBD 5EEMA 5LI3A 5EFGA 4BZ8A 5ICNB 3C0YA 3EZPA 3C10A 4QA0A 3Q9CA 3MENA 1VKGA 5EFKB 2VQWG 3SFFA 3F06A 5G0XA 4RN2A 3EZTA 4ZURA 5EFHA 4ZUPA 5THUA 5DC6A 3F0RA 2VCGA 5DC8A 1ZZ0A 1ZZ3A 2V5WA 5G0JA 4RN1A 5DC5A 1ZZ1A 1C3RA 3MAXA 4CBYA 5G1BA 4BZ9A 5JI5A 5G13A 5IWGA 4LXZA 4CBTA 5D1DA 5D1CA 4ZUNA 4BKXB 3EW8A 3Q9BA 5EFNA 2VQMA 2VQJA 4QA7A 3EWFA 5FUEA 5DC7A 5EFJD 5G0YA 3ZNRA 2V5XA 5G0IA 5BWZA 5G0GA 1T69A 4BZ5A 5G0HA 5G10A 5THSA 5EEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5THV A;  3ZNS A;  5G11 A;  4QA1 A;  4BZ7 A;  1W22 A;  5FCW A;  4QA3 A;  3MZ3 A;  2VQV A;  3RQD A;  4RN0 A;  5EEF A;  5EF8 A;  3C0Z A;  4QA6 A;  2GH6 A;  3F07 A;  5G17 A;  3MZ6 A;  3Q9E A;  5THT A;  4LY1 A;  5D1B A;  4ZUQ A;  1C3P A;  5G3W A;  4QA4 A;  5EEI A;  1C3S A;  4ZUO A;  2VQQ A;  3MZ7 A;  4BZ6 A;  4CQF A;  5A2S A;  5EEN A;  2VQO A;  4ZUM A;  3Q9F A;  5G1C A;  3MZ4 A;  1T64 A;  3SFH A;  4QA2 A;  5G12 A;  4A69 A;  5IX0 A;  1T67 A;  4QA5 A;  5EF7 A;  5G1A A;  5EFB D;  5EEM A;  5LI3 A;  5EFG A;  4BZ8 A;  5ICN B;  3C0Y A;  3EZP A;  3C10 A;  4QA0 A;  3Q9C A;  3MEN A;  1VKG A;  5EFK B;  2VQW G;  3SFF A;  3F06 A;  5G0X A;  4RN2 A;  3EZT A;  4ZUR A;  5EFH A;  4ZUP A;  5THU A;  5DC6 A;  3F0R A;  2VCG A;  5DC8 A;  1ZZ0 A;  1ZZ3 A;  2V5W A;  5G0J A;  4RN1 A;  5DC5 A;  1ZZ1 A;  1C3R A;  3MAX A;  4CBY A;  5G1B A;  4BZ9 A;  5JI5 A;  5G13 A;  5IWG A;  4LXZ A;  4CBT A;  5D1D A;  5D1C A;  4ZUN A;  4BKX B;  3EW8 A;  3Q9B A;  5EFN A;  2VQM A;  2VQJ A;  4QA7 A;  3EWF A;  5FUE A;  5DC7 A;  5EFJ D;  5G0Y A;  3ZNR A;  2V5X A;  5G0I A;  5BWZ A;  5G0G A;  1T69 A;  4BZ5 A;  5G0H A;  5G10 A;  5THS A;  5EEK A; 
#chains in the Genus database with same CATH topology
 1T5F A;  3F80 A;  5THV A;  3ZNS A;  5G11 A;  4QA1 A;  4BZ7 A;  1GQ6 A;  1T4S A;  1CEV A;  1WVB A;  5CEV A;  1HQH A;  1W22 A;  5FCW A;  4QA3 A;  4IU5 A;  4RHK A;  4MYK A;  5RLA A;  3MZ3 A;  2VQV A;  4MYN A;  3RQD A;  4RN0 A;  5EEF A;  4IE3 A;  5EF8 A;  3C0Z A;  4QA6 A;  2GH6 A;  3F07 A;  5G17 A;  4RHM A;  3MZ6 A;  4HZE A;  3Q9E A;  5THT A;  1HQX A;  4LY1 A;  4RHQ A;  3E6K A;  5D1B A;  2RLA A;  4ZUQ A;  1C3P A;  2ZAV A;  5G3W A;  4QA4 A;  5EEI A;  3THJ A;  1C3S A;  4GSZ A;  2VQQ A;  3MZ7 A;  1TBJ A;  4ZUO A;  2EF5 A;  3GMZ A;  4BZ6 A;  4CQF A;  5A2S A;  5EEN A;  2VQO A;  4ZUM A;  3Q9F A;  5G1C A;  3MZ4 A;  1T64 A;  4Q3U A;  3SFH A;  4IE1 A;  1P8O A;  4IXV A;  4QA2 A;  1P8R A;  1HQG A;  1R1O A;  4HWW A;  4Q3R A;  5G12 A;  4CEV A;  1WOG A;  4A69 A;  1HQ5 A;  5IX0 A;  1T67 A;  4Q41 A;  4GSM A;  4QA5 A;  5EF7 A;  2EF4 A;  5HJ9 A;  5G1A A;  5EFB D;  3E9B A;  5EEM A;  5LI3 A;  4HXQ A;  5EFG A;  4BZ8 A;  2AEB A;  4RLA A;  5ICN B;  3THH A;  4Q40 A;  3MFV A;  4IU0 A;  4I06 A;  3C0Y A;  1T4P A;  1P8M A;  1HQF A;  4Q3S A;  1P8P A;  3EZP A;  3C10 A;  2PLL A;  4QA0 A;  3LHL A;  3Q9C A;  4DZ4 A;  3MEN A;  1VKG A;  5EFK B;  2VQW G;  3SFF A;  3F06 A;  1WVA A;  4IU4 A;  1TA1 A;  4Q3P A;  3KV2 A;  1WOI A;  4RHJ A;  5G0X A;  1P8Q A;  3NIO A;  4Q42 A;  4RN2 A;  3SKK A;  3EZT A;  4GSV A;  4ZUR A;  5EFH A;  1WOH A;  2PHO A;  5DC6 A;  3F0R A;  2VCG A;  5DC8 A;  4ZUP A;  1ZZ0 A;  3MMR A;  5THU A;  1ZZ3 A;  2V5W A;  3NIP A;  4IXU A;  4RN1 A;  1ZZ1 A;  1C3R A;  3MAX A;  5DC5 A;  5G0J A;  4CBY A;  5G1B A;  2CEV A;  3PZL A;  4RHI A;  2PHA A;  1T4R A;  3LP4 A;  4BZ9 A;  1P8S A;  1P8N A;  5G13 A;  4MXR A;  5IWG A;  4LXZ A;  3CEV A;  1PQ3 A;  3SL0 A;  5JI5 A;  3MFW A;  4Q3R C;  1TBH A;  3E8Q A;  3MJL A;  4CBT A;  1T4T A;  4Q3V A;  5D1D A;  5D1C A;  1RLA A;  4ZUN A;  4RHL A;  4BKX B;  3E8Z A;  3EW8 A;  3RLA A;  3THE A;  3TH7 A;  3NIQ A;  1ZPG A;  3DJ8 A;  4Q3T A;  3Q9B A;  5EFN A;  3E6V A;  4GWC A;  2VQM A;  3GN0 A;  4ITY A;  4IE2 A;  3SJT A;  3SL1 A;  3M1R A;  2VQJ A;  1GQ7 A;  1D3V A;  4GWD A;  4IU1 A;  4QA7 A;  3EWF A;  5FUE A;  5DC7 A;  2A0M A;  5EFJ D;  1ZPE A;  5G0Y A;  3ZNR A;  2V5X A;  1TBL A;  4MYF A;  5G0I A;  4FCI A;  5BWZ A;  4G3H A;  1T5G A;  5G0G A;  3LP7 A;  1T69 A;  4BZ5 A;  5G0H A;  4FCK A;  4MYL A;  5G10 A;  5THS A;  4Q3Q A;  5HJA A;  2EIV A;  1XFK A;  5EEK A;  3TF3 A; 
#chains in the Genus database with same CATH homology
 5THV A;  3ZNS A;  5G11 A;  4QA1 A;  4BZ7 A;  1W22 A;  5FCW A;  4QA3 A;  3MZ3 A;  2VQV A;  3RQD A;  4RN0 A;  5EEF A;  5EF8 A;  3C0Z A;  4QA6 A;  2GH6 A;  3F07 A;  5G17 A;  3MZ6 A;  3Q9E A;  5THT A;  4LY1 A;  5D1B A;  4ZUQ A;  1C3P A;  5G3W A;  4QA4 A;  5EEI A;  1C3S A;  4ZUO A;  2VQQ A;  3MZ7 A;  4BZ6 A;  4CQF A;  5A2S A;  5EEN A;  2VQO A;  4ZUM A;  3Q9F A;  5G1C A;  3MZ4 A;  1T64 A;  3SFH A;  4QA2 A;  5G12 A;  4A69 A;  5IX0 A;  1T67 A;  4QA5 A;  5EF7 A;  5G1A A;  5EFB D;  5EEM A;  5LI3 A;  5EFG A;  4BZ8 A;  5ICN B;  3C0Y A;  3EZP A;  3C10 A;  4QA0 A;  3Q9C A;  3MEN A;  1VKG A;  5EFK B;  2VQW G;  3SFF A;  3F06 A;  5G0X A;  4RN2 A;  3EZT A;  4ZUR A;  5EFH A;  4ZUP A;  5THU A;  5DC6 A;  3F0R A;  2VCG A;  5DC8 A;  1ZZ0 A;  1ZZ3 A;  2V5W A;  5G0J A;  4RN1 A;  5DC5 A;  1ZZ1 A;  1C3R A;  3MAX A;  4CBY A;  5G1B A;  4BZ9 A;  5JI5 A;  5G13 A;  5IWG A;  4LXZ A;  4CBT A;  5D1D A;  5D1C A;  4ZUN A;  4BKX B;  3EW8 A;  3Q9B A;  5EFN A;  2VQM A;  2VQJ A;  4QA7 A;  3EWF A;  5FUE A;  5DC7 A;  5EFJ D;  5G0Y A;  3ZNR A;  2V5X A;  5G0I A;  5BWZ A;  5G0G A;  1T69 A;  4BZ5 A;  5G0H A;  5G10 A;  5THS A;  5EEK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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