2VQQA

Structure of hdac4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
399
structure length
361
Chain Sequence
RFTTGLVYDTLMLKHQHAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHTLLYGTNPLVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HISTONE DEACETYLASE 4
publication title Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 132
structure length 361
sequence length 399
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-03-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 2vqqA00
5BWZA 2VCGA 1VKGA 5THVA 5EFGA 2VQWG 5D1BA 4ZUOA 5G0HA 4QA0A 5EF8A 1T67A 5EEMA 3EZTA 3ZNRA 2VQMA 3MZ7A 4ZUQA 4ZUNA 2VQOA 5ICNB 4BZ7A 5G11A 5G3WA 4CBTA 5THUA 4QA7A 5IX0A 2GH6A 3EW8A 5LI3A 5DC6A 5EFJD 1C3RA 1T69A 2VQVA 4BZ5A 4RN0A 3C10A 3F07A 5DC7A 5FUEA 4QA2A 4BZ8A 4ZUMA 5EFBD 3MZ4A 3RQDA 5G10A 4CQFA 5EEIA 1ZZ0A 3ZNSA 3MENA 5EFHA 5DC8A 1C3SA 5D1DA 1ZZ3A 5G17A 3Q9FA 5G0XA 4QA1A 5FCWA 4BZ6A 2V5WA 1ZZ1A 5IWGA 3MZ6A 5A2SA 5G1BA 1W22A 5G12A 4LY1A 5G0IA 3EWFA 3F0RA 4A69A 3F06A 5EEFA 1C3PA 4ZURA 5THTA 5EEKA 1T64A 5G1CA 5G0YA 2V5XA 3SFHA 4QA5A 3MZ3A 5DC5A 4QA6A 5EF7A 5EFNA 3SFFA 5G13A 5D1CA 5G0JA 3EZPA 4CBYA 3Q9CA 4ZUPA 5EENA 3C0YA 4BZ9A 2VQQA 5JI5A 3MAXA 2VQJA 4LXZA 5G1AA 5G0GA 4QA4A 3Q9EA 4BKXB 4QA3A 3Q9BA 4RN1A 5EFKB 4RN2A 5THSA 3C0ZA
chains in the Genus database with same CATH superfamily
4Q3RC 5BWZA 2VCGA 1VKGA 5THVA 3E9BA 5EFGA 4HWWA 5THSA 2VQWG 5D1BA 5RLAA 4ZUOA 5G0HA 4QA0A 5EF8A 3F80A 1P8NA 1RLAA 1T67A 5CEVA 5EEMA 3EZTA 4ITYA 3NIOA 2CEVA 3ZNRA 2VQMA 4HZEA 1ZPEA 3E6VA 3MZ7A 4ZUQA 4ZUNA 2VQOA 2AEBA 4IU1A 1HQFA 3NIPA 5ICNB 4RN2A 1WOHA 2PHAA 4BZ7A 5G11A 5G3WA 3DJ8A 1HQXA 1HQGA 4CBTA 5THUA 4QA7A 5HJ9A 5IX0A 2A0MA 4GSVA 2EIVA 3SL0A 5A2SA 2GH6A 3EW8A 3LP4A 5LI3A 1P8OA 2ZAVA 3MFVA 5DC6A 5EFJD 1C3RA 1T69A 1WOGA 4I06A 2VQVA 3MMRA 4RHIA 1CEVA 1GQ6A 3PZLA 3SJTA 4BZ5A 4RN0A 1T4SA 3E8ZA 3F07A 4QA2A 5DC7A 5FUEA 4FCIA 1D3VA 4ZUMA 4BZ8A 4RHJA 5EFBD 3MZ4A 4GWDA 4IE3A 3RQDA 4DZ4A 1WOIA 5G10A 4IU4A 4CQFA 3CEVA 5EEIA 1ZZ0A 3ZNSA 3MENA 4RLAA 4IE2A 4Q3UA 5EFHA 1TBLA 5DC8A 1C3SA 1T4TA 1PQ3A 3MFWA 5D1DA 1ZZ3A 3KV2A 5G17A 2RLAA 1P8PA 2PLLA 2EF4A 3Q9FA 4GSZA 4IXUA 5G0XA 4G3HA 4QA1A 5FCWA 3THJA 4BZ6A 2PHOA 3LP7A 2V5WA 3M1RA 1ZZ1A 1T4PA 1T4RA 4Q40A 5IWGA 3MZ6A 3THEA 4CEVA 5G1BA 1T5FA 1W22A 1TBJA 4GWCA 4MYFA 4GSMA 4LY1A 4MYNA 4RHQA 1WVAA 5G12A 5G0IA 3LHLA 3EWFA 3F0RA 4A69A 3E8QA 3F06A 5EEFA 4MXRA 3THHA 3SL1A 1C3PA 4ZURA 5THTA 1HQ5A 4Q3SA 1ZPGA 1XFKA 5EEKA 1T64A 5G1CA 5G0YA 2V5XA 1HQHA 3SFHA 4Q3QA 4QA5A 4Q3VA 3SKKA 4IU0A 3GN0A 3MZ3A 1P8MA 4IU5A 4RHKA 4QA6A 5DC5A 3TF3A 5EF7A 5EFNA 3NIQA 4Q3TA 3SFFA 5G13A 5D1CA 5G0JA 1P8QA 4IXVA 1R1OA 1TBHA 3EZPA 4HXQA 4RHMA 3MJLA 3GMZA 3Q9CA 4ZUPA 4CBYA 5EENA 3C0YA 4BZ9A 2VQQA 5JI5A 3RLAA 1T5GA 3MAXA 3E6KA 2VQJA 1TA1A 4LXZA 1WVBA 5HJAA 4Q3PA 4MYKA 5G0GA 5G1AA 1P8SA 2EF5A 4QA4A 3Q9EA 4BKXB 4QA3A 3Q9BA 4FCKA 4Q42A 3TH7A 4MYLA 4RHLA 4RN1A 4Q41A 4IE1A 5EFKB 4Q3RA 3C10A 1GQ7A 3C0ZA 1P8RA
chains in the Genus database with same CATH topology
5BWZA 2VCGA 1VKGA 5THVA 5EFGA 2VQWG 5D1BA 4ZUOA 5G0HA 4QA0A 5EF8A 1T67A 5EEMA 3EZTA 3ZNRA 2VQMA 3MZ7A 4ZUQA 4ZUNA 2VQOA 5ICNB 4BZ7A 5G11A 5G3WA 4CBTA 5THUA 4QA7A 5IX0A 2GH6A 3EW8A 5LI3A 5DC6A 5EFJD 1C3RA 1T69A 2VQVA 4BZ5A 4RN0A 3C10A 3F07A 5DC7A 5FUEA 4QA2A 4BZ8A 4ZUMA 5EFBD 3MZ4A 3RQDA 5G10A 4CQFA 5EEIA 1ZZ0A 3ZNSA 3MENA 5EFHA 5DC8A 1C3SA 5D1DA 1ZZ3A 5G17A 3Q9FA 5G0XA 4QA1A 5FCWA 4BZ6A 2V5WA 1ZZ1A 5IWGA 3MZ6A 5A2SA 5G1BA 1W22A 5G12A 4LY1A 5G0IA 3EWFA 3F0RA 4A69A 3F06A 5EEFA 1C3PA 4ZURA 5THTA 5EEKA 1T64A 5G1CA 5G0YA 2V5XA 3SFHA 4QA5A 3MZ3A 5DC5A 4QA6A 5EF7A 5EFNA 3SFFA 5G13A 5D1CA 5G0JA 3EZPA 4CBYA 3Q9CA 4ZUPA 5EENA 3C0YA 4BZ9A 2VQQA 5JI5A 3MAXA 2VQJA 4LXZA 5G1AA 5G0GA 4QA4A 3Q9EA 4BKXB 4QA3A 3Q9BA 4RN1A 5EFKB 4RN2A 5THSA 3C0ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5BWZ A;  2VCG A;  1VKG A;  5THV A;  5EFG A;  2VQW G;  5D1B A;  4ZUO A;  5G0H A;  4QA0 A;  5EF8 A;  1T67 A;  5EEM A;  3EZT A;  3ZNR A;  2VQM A;  3MZ7 A;  4ZUQ A;  4ZUN A;  2VQO A;  5ICN B;  4BZ7 A;  5G11 A;  5G3W A;  4CBT A;  5THU A;  4QA7 A;  5IX0 A;  2GH6 A;  3EW8 A;  5LI3 A;  5DC6 A;  5EFJ D;  1C3R A;  1T69 A;  2VQV A;  4BZ5 A;  4RN0 A;  3C10 A;  3F07 A;  5DC7 A;  5FUE A;  4QA2 A;  4BZ8 A;  4ZUM A;  5EFB D;  3MZ4 A;  3RQD A;  5G10 A;  4CQF A;  5EEI A;  1ZZ0 A;  3ZNS A;  3MEN A;  5EFH A;  5DC8 A;  1C3S A;  5D1D A;  1ZZ3 A;  5G17 A;  3Q9F A;  5G0X A;  4QA1 A;  5FCW A;  4BZ6 A;  2V5W A;  1ZZ1 A;  5IWG A;  3MZ6 A;  5A2S A;  5G1B A;  1W22 A;  5G12 A;  4LY1 A;  5G0I A;  3EWF A;  3F0R A;  4A69 A;  3F06 A;  5EEF A;  1C3P A;  4ZUR A;  5THT A;  5EEK A;  1T64 A;  5G1C A;  5G0Y A;  2V5X A;  3SFH A;  4QA5 A;  3MZ3 A;  5DC5 A;  4QA6 A;  5EF7 A;  5EFN A;  3SFF A;  5G13 A;  5D1C A;  5G0J A;  3EZP A;  4CBY A;  3Q9C A;  4ZUP A;  5EEN A;  3C0Y A;  4BZ9 A;  2VQQ A;  5JI5 A;  3MAX A;  2VQJ A;  4LXZ A;  5G1A A;  5G0G A;  4QA4 A;  3Q9E A;  4BKX B;  4QA3 A;  3Q9B A;  4RN1 A;  5EFK B;  4RN2 A;  5THS A;  3C0Z A; 
#chains in the Genus database with same CATH topology
 4Q3R C;  5BWZ A;  2VCG A;  1VKG A;  5THV A;  3E9B A;  5EFG A;  4HWW A;  5THS A;  2VQW G;  5D1B A;  5RLA A;  4ZUO A;  5G0H A;  4QA0 A;  5EF8 A;  3F80 A;  1P8N A;  1RLA A;  1T67 A;  5CEV A;  5EEM A;  3EZT A;  4ITY A;  3NIO A;  2CEV A;  3ZNR A;  2VQM A;  4HZE A;  1ZPE A;  3E6V A;  3MZ7 A;  4ZUQ A;  4ZUN A;  2VQO A;  2AEB A;  4IU1 A;  1HQF A;  3NIP A;  5ICN B;  4RN2 A;  1WOH A;  2PHA A;  4BZ7 A;  5G11 A;  5G3W A;  3DJ8 A;  1HQX A;  1HQG A;  4CBT A;  5THU A;  4QA7 A;  5HJ9 A;  5IX0 A;  2A0M A;  4GSV A;  2EIV A;  3SL0 A;  5A2S A;  2GH6 A;  3EW8 A;  3LP4 A;  5LI3 A;  1P8O A;  2ZAV A;  3MFV A;  5DC6 A;  5EFJ D;  1C3R A;  1T69 A;  1WOG A;  4I06 A;  2VQV A;  3MMR A;  4RHI A;  1CEV A;  1GQ6 A;  3PZL A;  3SJT A;  4BZ5 A;  4RN0 A;  1T4S A;  3E8Z A;  3F07 A;  4QA2 A;  5DC7 A;  5FUE A;  4FCI A;  1D3V A;  4ZUM A;  4BZ8 A;  4RHJ A;  5EFB D;  3MZ4 A;  4GWD A;  4IE3 A;  3RQD A;  4DZ4 A;  1WOI A;  5G10 A;  4IU4 A;  4CQF A;  3CEV A;  5EEI A;  1ZZ0 A;  3ZNS A;  3MEN A;  4RLA A;  4IE2 A;  4Q3U A;  5EFH A;  1TBL A;  5DC8 A;  1C3S A;  1T4T A;  1PQ3 A;  3MFW A;  5D1D A;  1ZZ3 A;  3KV2 A;  5G17 A;  2RLA A;  1P8P A;  2PLL A;  2EF4 A;  3Q9F A;  4GSZ A;  4IXU A;  5G0X A;  4G3H A;  4QA1 A;  5FCW A;  3THJ A;  4BZ6 A;  2PHO A;  3LP7 A;  2V5W A;  3M1R A;  1ZZ1 A;  1T4P A;  1T4R A;  4Q40 A;  5IWG A;  3MZ6 A;  3THE A;  4CEV A;  5G1B A;  1T5F A;  1W22 A;  1TBJ A;  4GWC A;  4MYF A;  4GSM A;  4LY1 A;  4MYN A;  4RHQ A;  1WVA A;  5G12 A;  5G0I A;  3LHL A;  3EWF A;  3F0R A;  4A69 A;  3E8Q A;  3F06 A;  5EEF A;  4MXR A;  3THH A;  3SL1 A;  1C3P A;  4ZUR A;  5THT A;  1HQ5 A;  4Q3S A;  1ZPG A;  1XFK A;  5EEK A;  1T64 A;  5G1C A;  5G0Y A;  2V5X A;  1HQH A;  3SFH A;  4Q3Q A;  4QA5 A;  4Q3V A;  3SKK A;  4IU0 A;  3GN0 A;  3MZ3 A;  1P8M A;  4IU5 A;  4RHK A;  4QA6 A;  5DC5 A;  3TF3 A;  5EF7 A;  5EFN A;  3NIQ A;  4Q3T A;  3SFF A;  5G13 A;  5D1C A;  5G0J A;  1P8Q A;  4IXV A;  1R1O A;  1TBH A;  3EZP A;  4HXQ A;  4RHM A;  3MJL A;  3GMZ A;  3Q9C A;  4ZUP A;  4CBY A;  5EEN A;  3C0Y A;  4BZ9 A;  2VQQ A;  5JI5 A;  3RLA A;  1T5G A;  3MAX A;  3E6K A;  2VQJ A;  1TA1 A;  4LXZ A;  1WVB A;  5HJA A;  4Q3P A;  4MYK A;  5G0G A;  5G1A A;  1P8S A;  2EF5 A;  4QA4 A;  3Q9E A;  4BKX B;  4QA3 A;  3Q9B A;  4FCK A;  4Q42 A;  3TH7 A;  4MYL A;  4RHL A;  4RN1 A;  4Q41 A;  4IE1 A;  5EFK B;  4Q3R A;  3C10 A;  1GQ7 A;  3C0Z A;  1P8R A; 
#chains in the Genus database with same CATH homology
 5BWZ A;  2VCG A;  1VKG A;  5THV A;  5EFG A;  2VQW G;  5D1B A;  4ZUO A;  5G0H A;  4QA0 A;  5EF8 A;  1T67 A;  5EEM A;  3EZT A;  3ZNR A;  2VQM A;  3MZ7 A;  4ZUQ A;  4ZUN A;  2VQO A;  5ICN B;  4BZ7 A;  5G11 A;  5G3W A;  4CBT A;  5THU A;  4QA7 A;  5IX0 A;  2GH6 A;  3EW8 A;  5LI3 A;  5DC6 A;  5EFJ D;  1C3R A;  1T69 A;  2VQV A;  4BZ5 A;  4RN0 A;  3C10 A;  3F07 A;  5DC7 A;  5FUE A;  4QA2 A;  4BZ8 A;  4ZUM A;  5EFB D;  3MZ4 A;  3RQD A;  5G10 A;  4CQF A;  5EEI A;  1ZZ0 A;  3ZNS A;  3MEN A;  5EFH A;  5DC8 A;  1C3S A;  5D1D A;  1ZZ3 A;  5G17 A;  3Q9F A;  5G0X A;  4QA1 A;  5FCW A;  4BZ6 A;  2V5W A;  1ZZ1 A;  5IWG A;  3MZ6 A;  5A2S A;  5G1B A;  1W22 A;  5G12 A;  4LY1 A;  5G0I A;  3EWF A;  3F0R A;  4A69 A;  3F06 A;  5EEF A;  1C3P A;  4ZUR A;  5THT A;  5EEK A;  1T64 A;  5G1C A;  5G0Y A;  2V5X A;  3SFH A;  4QA5 A;  3MZ3 A;  5DC5 A;  4QA6 A;  5EF7 A;  5EFN A;  3SFF A;  5G13 A;  5D1C A;  5G0J A;  3EZP A;  4CBY A;  3Q9C A;  4ZUP A;  5EEN A;  3C0Y A;  4BZ9 A;  2VQQ A;  5JI5 A;  3MAX A;  2VQJ A;  4LXZ A;  5G1A A;  5G0G A;  4QA4 A;  3Q9E A;  4BKX B;  4QA3 A;  3Q9B A;  4RN1 A;  5EFK B;  4RN2 A;  5THS A;  3C0Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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