4BZ8A

Crystal structure of schistosoma mansoni hdac8 complexed with j1038
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
426
structure length
393
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPNSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HISTONE DEACETYLASE 8
publication title Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
pubmed doi rcsb
source organism Schistosoma mansoni
molecule tags Hydrolase
total genus 144
structure length 393
sequence length 426
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-07-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4bz8A00
5IWGA 5A2SA 1C3RA 3SFHA 5G10A 5D1BA 4RN1A 3F06A 3MZ7A 4RN2A 5EEIA 3MZ4A 5JI5A 5EF8A 5DC5A 5EEFA 4ZUOA 5G0JA 4BZ8A 4QA2A 5EFHA 3F07A 4BZ5A 5DC6A 5G0GA 4CBTA 2VQWG 5G0YA 4QA6A 5EFNA 5IX0A 2VQOA 3Q9EA 4RN0A 1C3PA 5G1BA 5ICNB 4BZ7A 5EEKA 5EEMA 5BWZA 5EFGA 2VCGA 2VQQA 3ZNRA 2VQJA 2GH6A 5D1DA 3MAXA 4CBYA 5G3WA 5FCWA 3MENA 5G1AA 4BKXB 3F0RA 5G0IA 1T67A 3Q9CA 1ZZ0A 5THUA 5G0XA 5EF7A 5THVA 5FUEA 4LY1A 5EENA 5G13A 5LI3A 4ZUQA 1VKGA 3RQDA 1T64A 4CQFA 3C0YA 4A69A 5G17A 4QA4A 5EFKB 4ZUMA 3EZTA 5DC8A 3MZ6A 5EFJD 5G1CA 4QA1A 3EZPA 5EFBD 1W22A 3C10A 4QA5A 1ZZ1A 2V5WA 2VQMA 3MZ3A 1ZZ3A 4QA7A 4BZ9A 1T69A 5THSA 5THTA 3Q9BA 2V5XA 1C3SA 2VQVA 4ZUNA 5G11A 5DC7A 4ZUPA 4ZURA 4LXZA 5G12A 3EWFA 4BZ6A 3ZNSA 3C0ZA 5D1CA 4QA0A 4QA3A 5G0HA 3SFFA 3EW8A 3Q9FA
chains in the Genus database with same CATH superfamily
4HWWA 5IWGA 1ZPGA 5A2SA 4RHQA 4FCIA 1C3RA 3NIQA 3SFHA 5G10A 5D1BA 4RN1A 3F06A 3MZ7A 4RN2A 3GN0A 5EEIA 3MZ4A 1WOHA 5JI5A 5EF8A 5DC5A 5EEFA 1WOGA 4ZUOA 4IE3A 4Q42A 4RHIA 5HJAA 4GWDA 5G0JA 3SKKA 4QA2A 4BZ8A 5EFHA 3F07A 4BZ5A 1R1OA 4Q3QA 4CEVA 4RLAA 5DC6A 4IU4A 5G0GA 4CBTA 2VQWG 2RLAA 3E9BA 4QA6A 5EFNA 2EIVA 5G0YA 2PHAA 2VQOA 3E6KA 3Q9EA 4ITYA 4RN0A 4RHKA 5IX0A 3RLAA 1C3PA 5G1BA 4Q41A 3F80A 3PZLA 1WVAA 3MMRA 5CEVA 5ICNB 4BZ7A 1TBHA 1HQXA 5EEKA 4IE1A 1T5GA 2PHOA 3MJLA 3LHLA 1P8NA 5EEMA 5BWZA 5EFGA 4IXUA 2VCGA 2VQQA 3ZNRA 2VQJA 1TBLA 1P8SA 4I06A 2GH6A 4Q3PA 5D1DA 3MAXA 2AEBA 1P8PA 4CBYA 5G3WA 1D3VA 4Q3RA 3THEA 5FCWA 3MENA 3THJA 5G1AA 4BKXB 2PLLA 1ZPEA 3F0RA 3GMZA 5G0IA 4Q3VA 1P8OA 4IXVA 1TA1A 3E8QA 1T67A 3Q9CA 1ZZ0A 5THUA 3LP7A 5G0XA 5HJ9A 1P8QA 5EF7A 4RHMA 5THVA 1PQ3A 5FUEA 3TH7A 1CEVA 2EF5A 1P8MA 4HXQA 4LY1A 5EENA 3MFWA 4MYLA 5G13A 3SL0A 4ZUQA 1VKGA 5LI3A 4FCKA 4Q40A 4GSVA 3CEVA 4DZ4A 2ZAVA 3RQDA 3NIPA 1HQGA 1T64A 3C0YA 4RHJA 4A69A 3M1RA 4IE2A 5G17A 4Q3SA 1WOIA 4QA4A 5EFKB 3EZTA 5EFJD 5DC8A 1HQFA 3MZ6A 3E6VA 4GSZA 4ZUMA 1RLAA 4QA1A 5G1CA 3KV2A 3EZPA 4HZEA 4MYFA 5EFBD 1W22A 3C10A 1XFKA 2A0MA 4QA5A 1ZZ1A 1HQ5A 2V5WA 3LP4A 2VQMA 3MZ3A 1ZZ3A 4QA7A 2EF4A 4RHLA 4BZ9A 2CEVA 3DJ8A 1T69A 3NIOA 4IU0A 4Q3TA 3E8ZA 5THSA 5THTA 4CQFA 1GQ6A 3SL1A 4G3HA 4Q3RC 3Q9BA 2V5XA 1T4PA 1TBJA 4GSMA 1C3SA 4IU1A 4MYNA 3MFVA 2VQVA 4MXRA 4ZUNA 5DC7A 5G11A 5RLAA 4ZUPA 4ZURA 1T4TA 4LXZA 4MYKA 1T5FA 5G12A 1P8RA 3SJTA 1T4RA 3EWFA 1WVBA 4BZ6A 4IU5A 3ZNSA 3C0ZA 5D1CA 3TF3A 4QA0A 1HQHA 1T4SA 4Q3UA 4QA3A 3THHA 4GWCA 5G0HA 3SFFA 3EW8A 1GQ7A 3Q9FA
chains in the Genus database with same CATH topology
5IWGA 5A2SA 1C3RA 3SFHA 5G10A 5D1BA 4RN1A 3F06A 3MZ7A 4RN2A 5EEIA 3MZ4A 5JI5A 5EF8A 5DC5A 5EEFA 4ZUOA 5G0JA 4BZ8A 4QA2A 5EFHA 3F07A 4BZ5A 5DC6A 5G0GA 4CBTA 2VQWG 5G0YA 4QA6A 5EFNA 5IX0A 2VQOA 3Q9EA 4RN0A 1C3PA 5G1BA 5ICNB 4BZ7A 5EEKA 5EEMA 5BWZA 5EFGA 2VCGA 2VQQA 3ZNRA 2VQJA 2GH6A 5D1DA 3MAXA 4CBYA 5G3WA 5FCWA 3MENA 5G1AA 4BKXB 3F0RA 5G0IA 1T67A 3Q9CA 1ZZ0A 5THUA 5G0XA 5EF7A 5THVA 5FUEA 4LY1A 5EENA 5G13A 5LI3A 4ZUQA 1VKGA 3RQDA 1T64A 4CQFA 3C0YA 4A69A 5G17A 4QA4A 5EFKB 4ZUMA 3EZTA 5DC8A 3MZ6A 5EFJD 5G1CA 4QA1A 3EZPA 5EFBD 1W22A 3C10A 4QA5A 1ZZ1A 2V5WA 2VQMA 3MZ3A 1ZZ3A 4QA7A 4BZ9A 1T69A 5THSA 5THTA 3Q9BA 2V5XA 1C3SA 2VQVA 4ZUNA 5G11A 5DC7A 4ZUPA 4ZURA 4LXZA 5G12A 3EWFA 4BZ6A 3ZNSA 3C0ZA 5D1CA 4QA0A 4QA3A 5G0HA 3SFFA 3EW8A 3Q9FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IWG A;  5A2S A;  1C3R A;  3SFH A;  5G10 A;  5D1B A;  4RN1 A;  3F06 A;  3MZ7 A;  4RN2 A;  5EEI A;  3MZ4 A;  5JI5 A;  5EF8 A;  5DC5 A;  5EEF A;  4ZUO A;  5G0J A;  4BZ8 A;  4QA2 A;  5EFH A;  3F07 A;  4BZ5 A;  5DC6 A;  5G0G A;  4CBT A;  2VQW G;  5G0Y A;  4QA6 A;  5EFN A;  5IX0 A;  2VQO A;  3Q9E A;  4RN0 A;  1C3P A;  5G1B A;  5ICN B;  4BZ7 A;  5EEK A;  5EEM A;  5BWZ A;  5EFG A;  2VCG A;  2VQQ A;  3ZNR A;  2VQJ A;  2GH6 A;  5D1D A;  3MAX A;  4CBY A;  5G3W A;  5FCW A;  3MEN A;  5G1A A;  4BKX B;  3F0R A;  5G0I A;  1T67 A;  3Q9C A;  1ZZ0 A;  5THU A;  5G0X A;  5EF7 A;  5THV A;  5FUE A;  4LY1 A;  5EEN A;  5G13 A;  5LI3 A;  4ZUQ A;  1VKG A;  3RQD A;  1T64 A;  4CQF A;  3C0Y A;  4A69 A;  5G17 A;  4QA4 A;  5EFK B;  4ZUM A;  3EZT A;  5DC8 A;  3MZ6 A;  5EFJ D;  5G1C A;  4QA1 A;  3EZP A;  5EFB D;  1W22 A;  3C10 A;  4QA5 A;  1ZZ1 A;  2V5W A;  2VQM A;  3MZ3 A;  1ZZ3 A;  4QA7 A;  4BZ9 A;  1T69 A;  5THS A;  5THT A;  3Q9B A;  2V5X A;  1C3S A;  2VQV A;  4ZUN A;  5G11 A;  5DC7 A;  4ZUP A;  4ZUR A;  4LXZ A;  5G12 A;  3EWF A;  4BZ6 A;  3ZNS A;  3C0Z A;  5D1C A;  4QA0 A;  4QA3 A;  5G0H A;  3SFF A;  3EW8 A;  3Q9F A; 
#chains in the Genus database with same CATH topology
 4HWW A;  5IWG A;  1ZPG A;  5A2S A;  4RHQ A;  4FCI A;  1C3R A;  3NIQ A;  3SFH A;  5G10 A;  5D1B A;  4RN1 A;  3F06 A;  3MZ7 A;  4RN2 A;  3GN0 A;  5EEI A;  3MZ4 A;  1WOH A;  5JI5 A;  5EF8 A;  5DC5 A;  5EEF A;  1WOG A;  4ZUO A;  4IE3 A;  4Q42 A;  4RHI A;  5HJA A;  4GWD A;  5G0J A;  3SKK A;  4QA2 A;  4BZ8 A;  5EFH A;  3F07 A;  4BZ5 A;  1R1O A;  4Q3Q A;  4CEV A;  4RLA A;  5DC6 A;  4IU4 A;  5G0G A;  4CBT A;  2VQW G;  2RLA A;  3E9B A;  4QA6 A;  5EFN A;  2EIV A;  5G0Y A;  2PHA A;  2VQO A;  3E6K A;  3Q9E A;  4ITY A;  4RN0 A;  4RHK A;  5IX0 A;  3RLA A;  1C3P A;  5G1B A;  4Q41 A;  3F80 A;  3PZL A;  1WVA A;  3MMR A;  5CEV A;  5ICN B;  4BZ7 A;  1TBH A;  1HQX A;  5EEK A;  4IE1 A;  1T5G A;  2PHO A;  3MJL A;  3LHL A;  1P8N A;  5EEM A;  5BWZ A;  5EFG A;  4IXU A;  2VCG A;  2VQQ A;  3ZNR A;  2VQJ A;  1TBL A;  1P8S A;  4I06 A;  2GH6 A;  4Q3P A;  5D1D A;  3MAX A;  2AEB A;  1P8P A;  4CBY A;  5G3W A;  1D3V A;  4Q3R A;  3THE A;  5FCW A;  3MEN A;  3THJ A;  5G1A A;  4BKX B;  2PLL A;  1ZPE A;  3F0R A;  3GMZ A;  5G0I A;  4Q3V A;  1P8O A;  4IXV A;  1TA1 A;  3E8Q A;  1T67 A;  3Q9C A;  1ZZ0 A;  5THU A;  3LP7 A;  5G0X A;  5HJ9 A;  1P8Q A;  5EF7 A;  4RHM A;  5THV A;  1PQ3 A;  5FUE A;  3TH7 A;  1CEV A;  2EF5 A;  1P8M A;  4HXQ A;  4LY1 A;  5EEN A;  3MFW A;  4MYL A;  5G13 A;  3SL0 A;  4ZUQ A;  1VKG A;  5LI3 A;  4FCK A;  4Q40 A;  4GSV A;  3CEV A;  4DZ4 A;  2ZAV A;  3RQD A;  3NIP A;  1HQG A;  1T64 A;  3C0Y A;  4RHJ A;  4A69 A;  3M1R A;  4IE2 A;  5G17 A;  4Q3S A;  1WOI A;  4QA4 A;  5EFK B;  3EZT A;  5EFJ D;  5DC8 A;  1HQF A;  3MZ6 A;  3E6V A;  4GSZ A;  4ZUM A;  1RLA A;  4QA1 A;  5G1C A;  3KV2 A;  3EZP A;  4HZE A;  4MYF A;  5EFB D;  1W22 A;  3C10 A;  1XFK A;  2A0M A;  4QA5 A;  1ZZ1 A;  1HQ5 A;  2V5W A;  3LP4 A;  2VQM A;  3MZ3 A;  1ZZ3 A;  4QA7 A;  2EF4 A;  4RHL A;  4BZ9 A;  2CEV A;  3DJ8 A;  1T69 A;  3NIO A;  4IU0 A;  4Q3T A;  3E8Z A;  5THS A;  5THT A;  4CQF A;  1GQ6 A;  3SL1 A;  4G3H A;  4Q3R C;  3Q9B A;  2V5X A;  1T4P A;  1TBJ A;  4GSM A;  1C3S A;  4IU1 A;  4MYN A;  3MFV A;  2VQV A;  4MXR A;  4ZUN A;  5DC7 A;  5G11 A;  5RLA A;  4ZUP A;  4ZUR A;  1T4T A;  4LXZ A;  4MYK A;  1T5F A;  5G12 A;  1P8R A;  3SJT A;  1T4R A;  3EWF A;  1WVB A;  4BZ6 A;  4IU5 A;  3ZNS A;  3C0Z A;  5D1C A;  3TF3 A;  4QA0 A;  1HQH A;  1T4S A;  4Q3U A;  4QA3 A;  3THH A;  4GWC A;  5G0H A;  3SFF A;  3EW8 A;  1GQ7 A;  3Q9F A; 
#chains in the Genus database with same CATH homology
 5IWG A;  5A2S A;  1C3R A;  3SFH A;  5G10 A;  5D1B A;  4RN1 A;  3F06 A;  3MZ7 A;  4RN2 A;  5EEI A;  3MZ4 A;  5JI5 A;  5EF8 A;  5DC5 A;  5EEF A;  4ZUO A;  5G0J A;  4BZ8 A;  4QA2 A;  5EFH A;  3F07 A;  4BZ5 A;  5DC6 A;  5G0G A;  4CBT A;  2VQW G;  5G0Y A;  4QA6 A;  5EFN A;  5IX0 A;  2VQO A;  3Q9E A;  4RN0 A;  1C3P A;  5G1B A;  5ICN B;  4BZ7 A;  5EEK A;  5EEM A;  5BWZ A;  5EFG A;  2VCG A;  2VQQ A;  3ZNR A;  2VQJ A;  2GH6 A;  5D1D A;  3MAX A;  4CBY A;  5G3W A;  5FCW A;  3MEN A;  5G1A A;  4BKX B;  3F0R A;  5G0I A;  1T67 A;  3Q9C A;  1ZZ0 A;  5THU A;  5G0X A;  5EF7 A;  5THV A;  5FUE A;  4LY1 A;  5EEN A;  5G13 A;  5LI3 A;  4ZUQ A;  1VKG A;  3RQD A;  1T64 A;  4CQF A;  3C0Y A;  4A69 A;  5G17 A;  4QA4 A;  5EFK B;  4ZUM A;  3EZT A;  5DC8 A;  3MZ6 A;  5EFJ D;  5G1C A;  4QA1 A;  3EZP A;  5EFB D;  1W22 A;  3C10 A;  4QA5 A;  1ZZ1 A;  2V5W A;  2VQM A;  3MZ3 A;  1ZZ3 A;  4QA7 A;  4BZ9 A;  1T69 A;  5THS A;  5THT A;  3Q9B A;  2V5X A;  1C3S A;  2VQV A;  4ZUN A;  5G11 A;  5DC7 A;  4ZUP A;  4ZUR A;  4LXZ A;  5G12 A;  3EWF A;  4BZ6 A;  3ZNS A;  3C0Z A;  5D1C A;  4QA0 A;  4QA3 A;  5G0H A;  3SFF A;  3EW8 A;  3Q9F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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