1HQ5A

Crystal structure of the binuclear manganese metalloenzyme arginase complexed with s-(2-boronoethyl)-l-cysteine, an l-arginine analogue
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
308
structure length
308
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE 1
total genus 105
structure length 308
sequence length 308
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2000-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1hq5A00
1P8MA 4IE2A 1P8NA 4IXVA 3NIPA 4I06A 1WOHA 4HWWA 4MXRA 5CEVA 4IXUA 3NIOA 4RHIA 1HQ5A 4Q40A 1CEVA 4Q3RC 3KV2A 3E9BA 2AEBA 4IU0A 4HZEA 4MYFA 1WVAA 3GN0A 3M1RA 4IE1A 3MFVA 1GQ7A 1TBHA 4RHJA 1P8SA 2EIVA 2PHOA 2A0MA 1RLAA 1HQFA 4RHKA 1WOIA 3GMZA 1TA1A 3MMRA 4IU5A 1WVBA 4RHQA 3THEA 4IU1A 5HJAA 1P8OA 4Q3VA 1T4RA 4FCKA 4GWCA 4Q42A 1R1OA 1TBLA 3THHA 4IE3A 4GSVA 3SJTA 2RLAA 3LP4A 4Q3SA 4Q3UA 3E8ZA 2PHAA 3SL0A 1T4TA 2CEVA 3CEVA 3THJA 3MFWA 4MYNA 4IU4A 3TH7A 4Q3TA 4GSZA 4Q41A 3SL1A 1GQ6A 1P8PA 3DJ8A 1XFKA 1HQXA 4RHLA 5HJ9A 4RLAA 4FCIA 3LHLA 1D3VA 1PQ3A 2EF4A 4Q3QA 2ZAVA 1T4SA 4Q3RA 3RLAA 4ITYA 4G3HA 3F80A 2EF5A 1ZPGA 3NIQA 3LP7A 4HXQA 3E6VA 4RHMA 3E8QA 1ZPEA 4GSMA 3TF3A 1T5FA 3PZLA 2PLLA 4DZ4A 4GWDA 1T5GA 4MYLA 1HQHA 1P8RA 4Q3PA 5RLAA 1P8QA 1WOGA 1HQGA 1TBJA 3E6KA 4CEVA 3MJLA 1T4PA 4MYKA 3SKKA
chains in the Genus database with same CATH superfamily
5EF8A 5DC7A 3SFHA 1P8MA 1ZZ1A 4IE2A 1P8NA 4IXVA 5A2SA 3Q9FA 5LI3A 3NIPA 4I06A 4QA5A 1WOHA 4HWWA 4MXRA 5CEVA 5DC8A 5ICNB 1C3PA 3EWFA 4IXUA 2GH6A 3NIOA 4RHIA 1HQ5A 4Q40A 5EFJD 4BZ7A 5JI5A 5EFGA 5G3WA 1CEVA 4Q3RC 3KV2A 1T64A 5EFHA 5G1BA 3E9BA 2AEBA 4IU0A 4ZUPA 4HZEA 4MYFA 1WVAA 3GN0A 3C10A 3MZ6A 3M1RA 4IE1A 4QA2A 3MFVA 5IWGA 1GQ7A 1TBHA 4BZ6A 4RHJA 5D1BA 1P8SA 2EIVA 2PHOA 5THSA 2A0MA 3SFFA 1RLAA 5G10A 5EEIA 4ZUOA 1HQFA 4RHKA 3MZ4A 3RQDA 1T67A 1WOIA 4QA1A 5G13A 3GMZA 1TA1A 3EZTA 3MMRA 5EEMA 4IU5A 1WVBA 4RHQA 3THEA 3Q9EA 4IU1A 5HJAA 3ZNSA 5EFNA 4BZ9A 1C3SA 1P8OA 1T4RA 4FCKA 4Q3VA 4GWCA 4Q42A 5FUEA 2VQJA 4LY1A 5G0XA 1R1OA 1TBLA 3C0ZA 5G0JA 3THHA 4IE3A 4GSVA 3SJTA 1ZZ3A 2RLAA 3EZPA 3LP4A 5EEFA 3MZ7A 3MZ3A 4Q3SA 4Q3UA 5G0GA 1VKGA 3E8ZA 2VQQA 2PHAA 3F07A 5G12A 1T4TA 3SL0A 1W22A 2CEVA 4ZURA 3CEVA 5G0HA 3EW8A 3THJA 5G11A 3MFWA 4A69A 4CBYA 4MYNA 3F0RA 4IU4A 4Q3TA 4GSZA 5THTA 3TH7A 4Q41A 3SL1A 4QA6A 2V5XA 4RN0A 5IX0A 5D1CA 1GQ6A 5EFBD 1P8PA 3DJ8A 2VCGA 1XFKA 3Q9CA 1HQXA 4RHLA 5HJ9A 4ZUQA 4RLAA 4FCIA 3LHLA 1D3VA 1PQ3A 2EF4A 5G1AA 5G17A 4Q3QA 5THVA 2ZAVA 4RN1A 1T4SA 5EF7A 4Q3RA 5G0YA 3RLAA 5BWZA 4ITYA 5DC5A 4BZ8A 4G3HA 1ZZ0A 3F80A 1C3RA 1ZPGA 2VQVA 2EF5A 3NIQA 3LP7A 5EEKA 4ZUMA 4HXQA 3E6VA 4BZ5A 4RHMA 3MENA 2VQWG 1ZPEA 3C0YA 3E8QA 4GSMA 2V5WA 5FCWA 1T5FA 3TF3A 3PZLA 5THUA 2PLLA 5D1DA 4DZ4A 4GWDA 1T5GA 4MYLA 5EENA 4ZUNA 1HQHA 5EFKB 4QA4A 2VQOA 1T69A 3F06A 4RN2A 1P8RA 4Q3PA 5G0IA 5RLAA 1P8QA 1WOGA 3MAXA 4LXZA 1HQGA 1TBJA 3E6KA 2VQMA 3Q9BA 4CBTA 5DC6A 4CEVA 5G1CA 3ZNRA 4BKXB 4CQFA 4QA3A 3MJLA 1T4PA 4MYKA 4QA0A 3SKKA 4QA7A
chains in the Genus database with same CATH topology
1P8MA 4IE2A 1P8NA 4IXVA 3NIPA 4I06A 1WOHA 4HWWA 4MXRA 5CEVA 4IXUA 3NIOA 4RHIA 1HQ5A 4Q40A 1CEVA 4Q3RC 3KV2A 3E9BA 2AEBA 4IU0A 4HZEA 4MYFA 1WVAA 3GN0A 3M1RA 4IE1A 3MFVA 1GQ7A 1TBHA 4RHJA 1P8SA 2EIVA 2PHOA 2A0MA 1RLAA 1HQFA 4RHKA 1WOIA 3GMZA 1TA1A 3MMRA 4IU5A 1WVBA 4RHQA 3THEA 4IU1A 5HJAA 1P8OA 4Q3VA 1T4RA 4FCKA 4GWCA 4Q42A 1R1OA 1TBLA 3THHA 4IE3A 4GSVA 3SJTA 2RLAA 3LP4A 4Q3SA 4Q3UA 3E8ZA 2PHAA 3SL0A 1T4TA 2CEVA 3CEVA 3THJA 3MFWA 4MYNA 4IU4A 3TH7A 4Q3TA 4GSZA 4Q41A 3SL1A 1GQ6A 1P8PA 3DJ8A 1XFKA 1HQXA 4RHLA 5HJ9A 4RLAA 4FCIA 3LHLA 1D3VA 1PQ3A 2EF4A 4Q3QA 2ZAVA 1T4SA 4Q3RA 3RLAA 4ITYA 4G3HA 3F80A 2EF5A 1ZPGA 3NIQA 3LP7A 4HXQA 3E6VA 4RHMA 3E8QA 1ZPEA 4GSMA 3TF3A 1T5FA 3PZLA 2PLLA 4DZ4A 4GWDA 1T5GA 4MYLA 1HQHA 1P8RA 4Q3PA 5RLAA 1P8QA 1WOGA 1HQGA 1TBJA 3E6KA 4CEVA 3MJLA 1T4PA 4MYKA 3SKKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8M A;  4IE2 A;  1P8N A;  4IXV A;  3NIP A;  4I06 A;  1WOH A;  4HWW A;  4MXR A;  5CEV A;  4IXU A;  3NIO A;  4RHI A;  1HQ5 A;  4Q40 A;  1CEV A;  4Q3R C;  3KV2 A;  3E9B A;  2AEB A;  4IU0 A;  4HZE A;  4MYF A;  1WVA A;  3GN0 A;  3M1R A;  4IE1 A;  3MFV A;  1GQ7 A;  1TBH A;  4RHJ A;  1P8S A;  2EIV A;  2PHO A;  2A0M A;  1RLA A;  1HQF A;  4RHK A;  1WOI A;  3GMZ A;  1TA1 A;  3MMR A;  4IU5 A;  1WVB A;  4RHQ A;  3THE A;  4IU1 A;  5HJA A;  1P8O A;  4Q3V A;  1T4R A;  4FCK A;  4GWC A;  4Q42 A;  1R1O A;  1TBL A;  3THH A;  4IE3 A;  4GSV A;  3SJT A;  2RLA A;  3LP4 A;  4Q3S A;  4Q3U A;  3E8Z A;  2PHA A;  3SL0 A;  1T4T A;  2CEV A;  3CEV A;  3THJ A;  3MFW A;  4MYN A;  4IU4 A;  3TH7 A;  4Q3T A;  4GSZ A;  4Q41 A;  3SL1 A;  1GQ6 A;  1P8P A;  3DJ8 A;  1XFK A;  1HQX A;  4RHL A;  5HJ9 A;  4RLA A;  4FCI A;  3LHL A;  1D3V A;  1PQ3 A;  2EF4 A;  4Q3Q A;  2ZAV A;  1T4S A;  4Q3R A;  3RLA A;  4ITY A;  4G3H A;  3F80 A;  2EF5 A;  1ZPG A;  3NIQ A;  3LP7 A;  4HXQ A;  3E6V A;  4RHM A;  3E8Q A;  1ZPE A;  4GSM A;  3TF3 A;  1T5F A;  3PZL A;  2PLL A;  4DZ4 A;  4GWD A;  1T5G A;  4MYL A;  1HQH A;  1P8R A;  4Q3P A;  5RLA A;  1P8Q A;  1WOG A;  1HQG A;  1TBJ A;  3E6K A;  4CEV A;  3MJL A;  1T4P A;  4MYK A;  3SKK A; 
#chains in the Genus database with same CATH topology
 5EF8 A;  5DC7 A;  3SFH A;  1P8M A;  1ZZ1 A;  4IE2 A;  1P8N A;  4IXV A;  5A2S A;  3Q9F A;  5LI3 A;  3NIP A;  4I06 A;  4QA5 A;  1WOH A;  4HWW A;  4MXR A;  5CEV A;  5DC8 A;  5ICN B;  1C3P A;  3EWF A;  4IXU A;  2GH6 A;  3NIO A;  4RHI A;  1HQ5 A;  4Q40 A;  5EFJ D;  4BZ7 A;  5JI5 A;  5EFG A;  5G3W A;  1CEV A;  4Q3R C;  3KV2 A;  1T64 A;  5EFH A;  5G1B A;  3E9B A;  2AEB A;  4IU0 A;  4ZUP A;  4HZE A;  4MYF A;  1WVA A;  3GN0 A;  3C10 A;  3MZ6 A;  3M1R A;  4IE1 A;  4QA2 A;  3MFV A;  5IWG A;  1GQ7 A;  1TBH A;  4BZ6 A;  4RHJ A;  5D1B A;  1P8S A;  2EIV A;  2PHO A;  5THS A;  2A0M A;  3SFF A;  1RLA A;  5G10 A;  5EEI A;  4ZUO A;  1HQF A;  4RHK A;  3MZ4 A;  3RQD A;  1T67 A;  1WOI A;  4QA1 A;  5G13 A;  3GMZ A;  1TA1 A;  3EZT A;  3MMR A;  5EEM A;  4IU5 A;  1WVB A;  4RHQ A;  3THE A;  3Q9E A;  4IU1 A;  5HJA A;  3ZNS A;  5EFN A;  4BZ9 A;  1C3S A;  1P8O A;  1T4R A;  4FCK A;  4Q3V A;  4GWC A;  4Q42 A;  5FUE A;  2VQJ A;  4LY1 A;  5G0X A;  1R1O A;  1TBL A;  3C0Z A;  5G0J A;  3THH A;  4IE3 A;  4GSV A;  3SJT A;  1ZZ3 A;  2RLA A;  3EZP A;  3LP4 A;  5EEF A;  3MZ7 A;  3MZ3 A;  4Q3S A;  4Q3U A;  5G0G A;  1VKG A;  3E8Z A;  2VQQ A;  2PHA A;  3F07 A;  5G12 A;  1T4T A;  3SL0 A;  1W22 A;  2CEV A;  4ZUR A;  3CEV A;  5G0H A;  3EW8 A;  3THJ A;  5G11 A;  3MFW A;  4A69 A;  4CBY A;  4MYN A;  3F0R A;  4IU4 A;  4Q3T A;  4GSZ A;  5THT A;  3TH7 A;  4Q41 A;  3SL1 A;  4QA6 A;  2V5X A;  4RN0 A;  5IX0 A;  5D1C A;  1GQ6 A;  5EFB D;  1P8P A;  3DJ8 A;  2VCG A;  1XFK A;  3Q9C A;  1HQX A;  4RHL A;  5HJ9 A;  4ZUQ A;  4RLA A;  4FCI A;  3LHL A;  1D3V A;  1PQ3 A;  2EF4 A;  5G1A A;  5G17 A;  4Q3Q A;  5THV A;  2ZAV A;  4RN1 A;  1T4S A;  5EF7 A;  4Q3R A;  5G0Y A;  3RLA A;  5BWZ A;  4ITY A;  5DC5 A;  4BZ8 A;  4G3H A;  1ZZ0 A;  3F80 A;  1C3R A;  1ZPG A;  2VQV A;  2EF5 A;  3NIQ A;  3LP7 A;  5EEK A;  4ZUM A;  4HXQ A;  3E6V A;  4BZ5 A;  4RHM A;  3MEN A;  2VQW G;  1ZPE A;  3C0Y A;  3E8Q A;  4GSM A;  2V5W A;  5FCW A;  1T5F A;  3TF3 A;  3PZL A;  5THU A;  2PLL A;  5D1D A;  4DZ4 A;  4GWD A;  1T5G A;  4MYL A;  5EEN A;  4ZUN A;  1HQH A;  5EFK B;  4QA4 A;  2VQO A;  1T69 A;  3F06 A;  4RN2 A;  1P8R A;  4Q3P A;  5G0I A;  5RLA A;  1P8Q A;  1WOG A;  3MAX A;  4LXZ A;  1HQG A;  1TBJ A;  3E6K A;  2VQM A;  3Q9B A;  4CBT A;  5DC6 A;  4CEV A;  5G1C A;  3ZNR A;  4BKX B;  4CQF A;  4QA3 A;  3MJL A;  1T4P A;  4MYK A;  4QA0 A;  3SKK A;  4QA7 A; 
#chains in the Genus database with same CATH homology
 1P8M A;  4IE2 A;  1P8N A;  4IXV A;  3NIP A;  4I06 A;  1WOH A;  4HWW A;  4MXR A;  5CEV A;  4IXU A;  3NIO A;  4RHI A;  1HQ5 A;  4Q40 A;  1CEV A;  4Q3R C;  3KV2 A;  3E9B A;  2AEB A;  4IU0 A;  4HZE A;  4MYF A;  1WVA A;  3GN0 A;  3M1R A;  4IE1 A;  3MFV A;  1GQ7 A;  1TBH A;  4RHJ A;  1P8S A;  2EIV A;  2PHO A;  2A0M A;  1RLA A;  1HQF A;  4RHK A;  1WOI A;  3GMZ A;  1TA1 A;  3MMR A;  4IU5 A;  1WVB A;  4RHQ A;  3THE A;  4IU1 A;  5HJA A;  1P8O A;  4Q3V A;  1T4R A;  4FCK A;  4GWC A;  4Q42 A;  1R1O A;  1TBL A;  3THH A;  4IE3 A;  4GSV A;  3SJT A;  2RLA A;  3LP4 A;  4Q3S A;  4Q3U A;  3E8Z A;  2PHA A;  3SL0 A;  1T4T A;  2CEV A;  3CEV A;  3THJ A;  3MFW A;  4MYN A;  4IU4 A;  3TH7 A;  4Q3T A;  4GSZ A;  4Q41 A;  3SL1 A;  1GQ6 A;  1P8P A;  3DJ8 A;  1XFK A;  1HQX A;  4RHL A;  5HJ9 A;  4RLA A;  4FCI A;  3LHL A;  1D3V A;  1PQ3 A;  2EF4 A;  4Q3Q A;  2ZAV A;  1T4S A;  4Q3R A;  3RLA A;  4ITY A;  4G3H A;  3F80 A;  2EF5 A;  1ZPG A;  3NIQ A;  3LP7 A;  4HXQ A;  3E6V A;  4RHM A;  3E8Q A;  1ZPE A;  4GSM A;  3TF3 A;  1T5F A;  3PZL A;  2PLL A;  4DZ4 A;  4GWD A;  1T5G A;  4MYL A;  1HQH A;  1P8R A;  4Q3P A;  5RLA A;  1P8Q A;  1WOG A;  1HQG A;  1TBJ A;  3E6K A;  4CEV A;  3MJL A;  1T4P A;  4MYK A;  3SKK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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