1HQ5A

Crystal structure of the binuclear manganese metalloenzyme arginase complexed with s-(2-boronoethyl)-l-cysteine, an l-arginine analogue
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
308
structure length
308
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE 1
total genus 105
structure length 308
sequence length 308
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2000-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1hq5A00
4Q3RA 4ITYA 1P8SA 3M1RA 4IU1A 4RHKA 3THJA 1D3VA 4RHQA 4DZ4A 4GSZA 3SJTA 1P8RA 1WOHA 3MFWA 2ZAVA 2PHAA 4MYKA 3GN0A 4MYNA 1T5GA 3NIPA 4MYLA 4Q40A 1P8NA 3MJLA 1XFKA 3LP4A 3MMRA 1TBLA 3KV2A 4IE3A 4IXUA 1WVAA 1RLAA 4IU5A 4FCKA 4MYFA 1HQHA 3PZLA 4HZEA 2PLLA 4GSMA 4GWCA 1T4SA 2A0MA 4RHMA 1HQ5A 3E6KA 3THEA 3E8ZA 4Q3UA 2EIVA 3NIOA 3RLAA 3NIQA 4RHJA 4HWWA 1WVBA 4GWDA 1P8PA 3SL0A 3THHA 3TH7A 3LP7A 4CEVA 4IE1A 1R1OA 3MFVA 3DJ8A 4G3HA 4Q3SA 4Q41A 4IU4A 2PHOA 3F80A 4IE2A 4I06A 4Q3VA 1ZPGA 5HJAA 4HXQA 1P8OA 4GSVA 3E8QA 3SKKA 1GQ7A 1T4PA 4Q3PA 4RLAA 4FCIA 5CEVA 2RLAA 1T4RA 1PQ3A 1TBHA 1TA1A 1P8QA 3E9BA 2EF5A 4Q3TA 1GQ6A 3SL1A 1ZPEA 1TBJA 3E6VA 4Q42A 1HQXA 2EF4A 5RLAA 1P8MA 1CEVA 4MXRA 4RHLA 1WOGA 2AEBA 2CEVA 4IU0A 4Q3RC 3LHLA 4Q3QA 1WOIA 3GMZA 4IXVA 4RHIA 5HJ9A 1HQFA 1HQGA 3TF3A 1T4TA 3CEVA 1T5FA
chains in the Genus database with same CATH superfamily
4Q3RA 5G1AA 4ITYA 1P8SA 3M1RA 4IU1A 4RHKA 5D1CA 5G3WA 3SFHA 1D3VA 3THJA 4RHQA 4DZ4A 4GSZA 4QA3A 3SJTA 1P8RA 5THSA 1WOHA 3MFWA 5EF7A 2ZAVA 2PHAA 4MYKA 5JI5A 3MZ6A 4CQFA 3GN0A 4MYNA 1T5GA 5DC8A 3RQDA 5A2SA 3F06A 5G0XA 1ZZ1A 4QA4A 3NIPA 4MYLA 3ZNRA 3EZTA 4Q40A 1P8NA 3MJLA 1XFKA 3LP4A 3MMRA 4ZURA 2VQOA 5EF8A 5ICNB 1TBLA 5IWGA 5D1DA 3KV2A 3EZPA 4IE3A 4IXUA 1WVAA 1RLAA 4IU5A 3EWFA 4FCKA 4QA1A 4RN1A 4MYFA 5EENA 1HQHA 4ZUNA 5G0HA 3PZLA 4QA6A 4HZEA 3MZ4A 2PLLA 1C3RA 4GSMA 4GWCA 1T4SA 4BZ6A 2A0MA 4RHMA 1HQ5A 5DC6A 3E6KA 1W22A 5D1BA 3THEA 3E8ZA 4Q3UA 2EIVA 3NIOA 2V5WA 3RLAA 1T67A 3NIQA 4RHJA 5EEFA 4HWWA 1WVBA 4GWDA 1P8PA 3MENA 5EFJD 3SL0A 3THHA 4BZ5A 3TH7A 2VQQA 3MZ3A 3LP7A 4QA0A 4CEVA 4IE1A 1R1OA 4QA7A 3F07A 2V5XA 3Q9EA 3MFVA 3Q9CA 4RN2A 5G0IA 4BKXB 3DJ8A 4G3HA 3C0YA 4Q3SA 5G12A 4IU4A 1VKGA 2PHOA 3F80A 4IE2A 3MAXA 5EFBD 4Q41A 4QA2A 4LY1A 4I06A 5EFHA 4Q3VA 2VQVA 1ZPGA 5HJAA 4HXQA 1P8OA 4ZUMA 4GSVA 3E8QA 4A69A 3SKKA 5EEKA 5EEMA 1GQ7A 1T4PA 5THUA 4Q3PA 4RLAA 5G17A 5FCWA 4FCIA 5DC5A 5CEVA 2RLAA 1T4RA 1PQ3A 1TBHA 1ZZ3A 4ZUPA 1TA1A 3C0ZA 1P8QA 3E9BA 2EF5A 4Q3TA 1GQ6A 5FUEA 5EFKB 5THTA 3SL1A 1ZPEA 4RN0A 3F0RA 4BZ9A 1TBJA 3E6VA 1T69A 4Q42A 1HQXA 4ZUOA 2VQMA 4CBYA 2EF4A 5RLAA 2VQWG 5THVA 1P8MA 5G13A 1CEVA 2VQJA 4MXRA 4RHLA 3EW8A 1WOGA 3ZNSA 4BZ8A 5DC7A 5EEIA 5G10A 2AEBA 2VCGA 4CBTA 5BWZA 3Q9FA 2CEVA 4LXZA 3MZ7A 5G0YA 4IU0A 1ZZ0A 4Q3RC 3C10A 3LHLA 5G1BA 4Q3QA 5LI3A 4QA5A 1WOIA 3GMZA 5G11A 5G0JA 4IXVA 4RHIA 5HJ9A 1HQFA 4BZ7A 1HQGA 5EFNA 5IX0A 3TF3A 1T4TA 3CEVA 1C3PA 3SFFA 3Q9BA 4ZUQA 1C3SA 5G0GA 5EFGA 2GH6A 1T64A 5G1CA 1T5FA
chains in the Genus database with same CATH topology
4Q3RA 4ITYA 1P8SA 3M1RA 4IU1A 4RHKA 3THJA 1D3VA 4RHQA 4DZ4A 4GSZA 3SJTA 1P8RA 1WOHA 3MFWA 2ZAVA 2PHAA 4MYKA 3GN0A 4MYNA 1T5GA 3NIPA 4MYLA 4Q40A 1P8NA 3MJLA 1XFKA 3LP4A 3MMRA 1TBLA 3KV2A 4IE3A 4IXUA 1WVAA 1RLAA 4IU5A 4FCKA 4MYFA 1HQHA 3PZLA 4HZEA 2PLLA 4GSMA 4GWCA 1T4SA 2A0MA 4RHMA 1HQ5A 3E6KA 3THEA 3E8ZA 4Q3UA 2EIVA 3NIOA 3RLAA 3NIQA 4RHJA 4HWWA 1WVBA 4GWDA 1P8PA 3SL0A 3THHA 3TH7A 3LP7A 4CEVA 4IE1A 1R1OA 3MFVA 3DJ8A 4G3HA 4Q3SA 4Q41A 4IU4A 2PHOA 3F80A 4IE2A 4I06A 4Q3VA 1ZPGA 5HJAA 4HXQA 1P8OA 4GSVA 3E8QA 3SKKA 1GQ7A 1T4PA 4Q3PA 4RLAA 4FCIA 5CEVA 2RLAA 1T4RA 1PQ3A 1TBHA 1TA1A 1P8QA 3E9BA 2EF5A 4Q3TA 1GQ6A 3SL1A 1ZPEA 1TBJA 3E6VA 4Q42A 1HQXA 2EF4A 5RLAA 1P8MA 1CEVA 4MXRA 4RHLA 1WOGA 2AEBA 2CEVA 4IU0A 4Q3RC 3LHLA 4Q3QA 1WOIA 3GMZA 4IXVA 4RHIA 5HJ9A 1HQFA 1HQGA 3TF3A 1T4TA 3CEVA 1T5FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q3R A;  4ITY A;  1P8S A;  3M1R A;  4IU1 A;  4RHK A;  3THJ A;  1D3V A;  4RHQ A;  4DZ4 A;  4GSZ A;  3SJT A;  1P8R A;  1WOH A;  3MFW A;  2ZAV A;  2PHA A;  4MYK A;  3GN0 A;  4MYN A;  1T5G A;  3NIP A;  4MYL A;  4Q40 A;  1P8N A;  3MJL A;  1XFK A;  3LP4 A;  3MMR A;  1TBL A;  3KV2 A;  4IE3 A;  4IXU A;  1WVA A;  1RLA A;  4IU5 A;  4FCK A;  4MYF A;  1HQH A;  3PZL A;  4HZE A;  2PLL A;  4GSM A;  4GWC A;  1T4S A;  2A0M A;  4RHM A;  1HQ5 A;  3E6K A;  3THE A;  3E8Z A;  4Q3U A;  2EIV A;  3NIO A;  3RLA A;  3NIQ A;  4RHJ A;  4HWW A;  1WVB A;  4GWD A;  1P8P A;  3SL0 A;  3THH A;  3TH7 A;  3LP7 A;  4CEV A;  4IE1 A;  1R1O A;  3MFV A;  3DJ8 A;  4G3H A;  4Q3S A;  4Q41 A;  4IU4 A;  2PHO A;  3F80 A;  4IE2 A;  4I06 A;  4Q3V A;  1ZPG A;  5HJA A;  4HXQ A;  1P8O A;  4GSV A;  3E8Q A;  3SKK A;  1GQ7 A;  1T4P A;  4Q3P A;  4RLA A;  4FCI A;  5CEV A;  2RLA A;  1T4R A;  1PQ3 A;  1TBH A;  1TA1 A;  1P8Q A;  3E9B A;  2EF5 A;  4Q3T A;  1GQ6 A;  3SL1 A;  1ZPE A;  1TBJ A;  3E6V A;  4Q42 A;  1HQX A;  2EF4 A;  5RLA A;  1P8M A;  1CEV A;  4MXR A;  4RHL A;  1WOG A;  2AEB A;  2CEV A;  4IU0 A;  4Q3R C;  3LHL A;  4Q3Q A;  1WOI A;  3GMZ A;  4IXV A;  4RHI A;  5HJ9 A;  1HQF A;  1HQG A;  3TF3 A;  1T4T A;  3CEV A;  1T5F A; 
#chains in the Genus database with same CATH topology
 4Q3R A;  5G1A A;  4ITY A;  1P8S A;  3M1R A;  4IU1 A;  4RHK A;  5D1C A;  5G3W A;  3SFH A;  1D3V A;  3THJ A;  4RHQ A;  4DZ4 A;  4GSZ A;  4QA3 A;  3SJT A;  1P8R A;  5THS A;  1WOH A;  3MFW A;  5EF7 A;  2ZAV A;  2PHA A;  4MYK A;  5JI5 A;  3MZ6 A;  4CQF A;  3GN0 A;  4MYN A;  1T5G A;  5DC8 A;  3RQD A;  5A2S A;  3F06 A;  5G0X A;  1ZZ1 A;  4QA4 A;  3NIP A;  4MYL A;  3ZNR A;  3EZT A;  4Q40 A;  1P8N A;  3MJL A;  1XFK A;  3LP4 A;  3MMR A;  4ZUR A;  2VQO A;  5EF8 A;  5ICN B;  1TBL A;  5IWG A;  5D1D A;  3KV2 A;  3EZP A;  4IE3 A;  4IXU A;  1WVA A;  1RLA A;  4IU5 A;  3EWF A;  4FCK A;  4QA1 A;  4RN1 A;  4MYF A;  5EEN A;  1HQH A;  4ZUN A;  5G0H A;  3PZL A;  4QA6 A;  4HZE A;  3MZ4 A;  2PLL A;  1C3R A;  4GSM A;  4GWC A;  1T4S A;  4BZ6 A;  2A0M A;  4RHM A;  1HQ5 A;  5DC6 A;  3E6K A;  1W22 A;  5D1B A;  3THE A;  3E8Z A;  4Q3U A;  2EIV A;  3NIO A;  2V5W A;  3RLA A;  1T67 A;  3NIQ A;  4RHJ A;  5EEF A;  4HWW A;  1WVB A;  4GWD A;  1P8P A;  3MEN A;  5EFJ D;  3SL0 A;  3THH A;  4BZ5 A;  3TH7 A;  2VQQ A;  3MZ3 A;  3LP7 A;  4QA0 A;  4CEV A;  4IE1 A;  1R1O A;  4QA7 A;  3F07 A;  2V5X A;  3Q9E A;  3MFV A;  3Q9C A;  4RN2 A;  5G0I A;  4BKX B;  3DJ8 A;  4G3H A;  3C0Y A;  4Q3S A;  5G12 A;  4IU4 A;  1VKG A;  2PHO A;  3F80 A;  4IE2 A;  3MAX A;  5EFB D;  4Q41 A;  4QA2 A;  4LY1 A;  4I06 A;  5EFH A;  4Q3V A;  2VQV A;  1ZPG A;  5HJA A;  4HXQ A;  1P8O A;  4ZUM A;  4GSV A;  3E8Q A;  4A69 A;  3SKK A;  5EEK A;  5EEM A;  1GQ7 A;  1T4P A;  5THU A;  4Q3P A;  4RLA A;  5G17 A;  5FCW A;  4FCI A;  5DC5 A;  5CEV A;  2RLA A;  1T4R A;  1PQ3 A;  1TBH A;  1ZZ3 A;  4ZUP A;  1TA1 A;  3C0Z A;  1P8Q A;  3E9B A;  2EF5 A;  4Q3T A;  1GQ6 A;  5FUE A;  5EFK B;  5THT A;  3SL1 A;  1ZPE A;  4RN0 A;  3F0R A;  4BZ9 A;  1TBJ A;  3E6V A;  1T69 A;  4Q42 A;  1HQX A;  4ZUO A;  2VQM A;  4CBY A;  2EF4 A;  5RLA A;  2VQW G;  5THV A;  1P8M A;  5G13 A;  1CEV A;  2VQJ A;  4MXR A;  4RHL A;  3EW8 A;  1WOG A;  3ZNS A;  4BZ8 A;  5DC7 A;  5EEI A;  5G10 A;  2AEB A;  2VCG A;  4CBT A;  5BWZ A;  3Q9F A;  2CEV A;  4LXZ A;  3MZ7 A;  5G0Y A;  4IU0 A;  1ZZ0 A;  4Q3R C;  3C10 A;  3LHL A;  5G1B A;  4Q3Q A;  5LI3 A;  4QA5 A;  1WOI A;  3GMZ A;  5G11 A;  5G0J A;  4IXV A;  4RHI A;  5HJ9 A;  1HQF A;  4BZ7 A;  1HQG A;  5EFN A;  5IX0 A;  3TF3 A;  1T4T A;  3CEV A;  1C3P A;  3SFF A;  3Q9B A;  4ZUQ A;  1C3S A;  5G0G A;  5EFG A;  2GH6 A;  1T64 A;  5G1C A;  1T5F A; 
#chains in the Genus database with same CATH homology
 4Q3R A;  4ITY A;  1P8S A;  3M1R A;  4IU1 A;  4RHK A;  3THJ A;  1D3V A;  4RHQ A;  4DZ4 A;  4GSZ A;  3SJT A;  1P8R A;  1WOH A;  3MFW A;  2ZAV A;  2PHA A;  4MYK A;  3GN0 A;  4MYN A;  1T5G A;  3NIP A;  4MYL A;  4Q40 A;  1P8N A;  3MJL A;  1XFK A;  3LP4 A;  3MMR A;  1TBL A;  3KV2 A;  4IE3 A;  4IXU A;  1WVA A;  1RLA A;  4IU5 A;  4FCK A;  4MYF A;  1HQH A;  3PZL A;  4HZE A;  2PLL A;  4GSM A;  4GWC A;  1T4S A;  2A0M A;  4RHM A;  1HQ5 A;  3E6K A;  3THE A;  3E8Z A;  4Q3U A;  2EIV A;  3NIO A;  3RLA A;  3NIQ A;  4RHJ A;  4HWW A;  1WVB A;  4GWD A;  1P8P A;  3SL0 A;  3THH A;  3TH7 A;  3LP7 A;  4CEV A;  4IE1 A;  1R1O A;  3MFV A;  3DJ8 A;  4G3H A;  4Q3S A;  4Q41 A;  4IU4 A;  2PHO A;  3F80 A;  4IE2 A;  4I06 A;  4Q3V A;  1ZPG A;  5HJA A;  4HXQ A;  1P8O A;  4GSV A;  3E8Q A;  3SKK A;  1GQ7 A;  1T4P A;  4Q3P A;  4RLA A;  4FCI A;  5CEV A;  2RLA A;  1T4R A;  1PQ3 A;  1TBH A;  1TA1 A;  1P8Q A;  3E9B A;  2EF5 A;  4Q3T A;  1GQ6 A;  3SL1 A;  1ZPE A;  1TBJ A;  3E6V A;  4Q42 A;  1HQX A;  2EF4 A;  5RLA A;  1P8M A;  1CEV A;  4MXR A;  4RHL A;  1WOG A;  2AEB A;  2CEV A;  4IU0 A;  4Q3R C;  3LHL A;  4Q3Q A;  1WOI A;  3GMZ A;  4IXV A;  4RHI A;  5HJ9 A;  1HQF A;  1HQG A;  3TF3 A;  1T4T A;  3CEV A;  1T5F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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