1HQHA

Crystal structure of the binuclear manganese metalloenzyme arginase complexed with nor-n-hydroxy-l-arginine
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE 1
total genus 106
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2000-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1hqhA00
5CEVA 1GQ6A 3MFVA 4RLAA 4IU4A 1TBHA 4ITYA 1TA1A 4RHKA 4IU5A 2ZAVA 1P8QA 3GN0A 4Q40A 4Q3VA 1XFKA 3E9BA 1T5GA 4GWCA 4Q3QA 3SL0A 4Q3SA 1T4RA 1WVBA 2CEVA 4IE2A 4GWDA 4Q3TA 1D3VA 3SJTA 4IE1A 3PZLA 4G3HA 1P8PA 3M1RA 1GQ7A 2AEBA 4GSMA 1WOIA 3MMRA 3DJ8A 4HZEA 1HQXA 3THEA 4IE3A 4IU0A 3KV2A 1R1OA 5HJ9A 2EIVA 5HJAA 3TF3A 1T4TA 3SL1A 1WOGA 4RHQA 1PQ3A 4Q3PA 3NIPA 3THHA 4Q42A 4Q41A 3GMZA 4GSZA 4MYKA 3NIQA 3F80A 3LHLA 4IXVA 2RLAA 1TBJA 1HQGA 4MYNA 3CEVA 4CEVA 1ZPGA 3RLAA 3MFWA 3THJA 1T4PA 1CEVA 4RHIA 2PHOA 1WVAA 3TH7A 4IU1A 4IXUA 2PHAA 1P8NA 4RHMA 1P8RA 4HXQA 4MYFA 4DZ4A 1RLAA 3LP7A 3E6KA 1P8OA 3SKKA 4FCIA 2EF5A 4FCKA 5RLAA 1HQ5A 3LP4A 2PLLA 2A0MA 1P8MA 4GSVA 4I06A 4RHLA 3E8QA 1T5FA 1TBLA 4RHJA 3E6VA 4Q3UA 3NIOA 3E8ZA 1T4SA 1P8SA 4MYLA 4Q3RC 1ZPEA 4MXRA 1HQHA 4HWWA 4Q3RA 1HQFA 1WOHA 2EF4A 3MJLA
chains in the Genus database with same CATH superfamily
5D1CA 5CEVA 1GQ6A 3MFVA 5EEFA 4RLAA 5G1BA 3Q9FA 4IU4A 3MENA 1TBHA 2VQJA 4ITYA 1TA1A 2VQMA 4BZ7A 4RHKA 4IU5A 2VQQA 3SFFA 3Q9BA 5IWGA 2ZAVA 3MZ6A 1ZZ3A 1P8QA 4CBYA 3GN0A 4Q40A 4Q3VA 1XFKA 3EZPA 3E9BA 1T5GA 4GWCA 3F0RA 4Q3QA 5G12A 5G17A 4ZUPA 4Q3SA 3SL0A 1T4RA 1WVBA 2CEVA 4IE2A 4GWDA 5DC8A 5DC6A 4Q3TA 4QA1A 2V5WA 1D3VA 5EF7A 3SJTA 5G0JA 4IE1A 3PZLA 4G3HA 1P8PA 3M1RA 5EENA 1GQ7A 2AEBA 5LI3A 4GSMA 1WOIA 3MMRA 3DJ8A 4HZEA 5G11A 5THVA 1HQXA 5DC7A 3ZNRA 3F06A 5EFHA 3THEA 4IE3A 5BWZA 3C0YA 5EFBD 4IU0A 5EFGA 4ZUQA 3KV2A 1R1OA 5HJ9A 2EIVA 2VQWG 3EW8A 4BZ9A 5HJAA 3TF3A 1T4TA 3SL1A 1ZZ1A 5EFJD 5DC5A 5EEMA 4BZ6A 4QA2A 5EEIA 1WOGA 1C3SA 5THUA 4RHQA 5THSA 4BKXB 3EWFA 1PQ3A 4Q3PA 3NIPA 5IX0A 3THHA 4Q42A 3SFHA 5G1AA 3GMZA 4Q41A 1C3PA 4GSZA 5EF8A 4MYKA 4ZUNA 3F80A 3NIQA 3LHLA 5G10A 4IXVA 4BZ8A 3MAXA 2RLAA 4RN0A 4BZ5A 1TBJA 1T69A 2V5XA 1HQGA 1T64A 4MYNA 3CEVA 4CEVA 1ZPGA 3RLAA 1VKGA 3MFWA 1W22A 5G13A 1T4PA 1T67A 1CEVA 3THJA 5A2SA 4RHIA 3ZNSA 4A69A 5G1CA 5THTA 2PHOA 4ZUOA 4LXZA 1WVAA 3TH7A 3F07A 3MZ7A 4IU1A 4ZUMA 4IXUA 2PHAA 1P8NA 4RHMA 5G0IA 1P8RA 2GH6A 4HXQA 4ZURA 3Q9CA 4MYFA 4QA7A 4DZ4A 5EEKA 1RLAA 3LP7A 4QA6A 4RN1A 3E6KA 1P8OA 3SKKA 5FUEA 4FCIA 2EF5A 4FCKA 5EFNA 4RN2A 3Q9EA 4QA4A 5D1BA 1WOHA 5RLAA 1HQ5A 3LP4A 5D1DA 5G0GA 4QA0A 3EZTA 2PLLA 3MZ4A 2A0MA 4QA5A 1P8MA 4CQFA 4GSVA 2VCGA 4I06A 5G0YA 4RHLA 3E8QA 1T5FA 1TBLA 4RHJA 3E6VA 1C3RA 4Q3UA 3MZ3A 3C10A 5G0XA 3RQDA 3NIOA 3E8ZA 5JI5A 4LY1A 5G0HA 1T4SA 2VQVA 5G3WA 1P8SA 4MYLA 1ZZ0A 4Q3RC 5EFKB 4CBTA 1ZPEA 5ICNB 4MXRA 3C0ZA 1HQHA 5FCWA 4HWWA 4Q3RA 1HQFA 4QA3A 2VQOA 2EF4A 3MJLA
chains in the Genus database with same CATH topology
5CEVA 1GQ6A 3MFVA 4RLAA 4IU4A 1TBHA 4ITYA 1TA1A 4RHKA 4IU5A 2ZAVA 1P8QA 3GN0A 4Q40A 4Q3VA 1XFKA 3E9BA 1T5GA 4GWCA 4Q3QA 3SL0A 4Q3SA 1T4RA 1WVBA 2CEVA 4IE2A 4GWDA 4Q3TA 1D3VA 3SJTA 4IE1A 3PZLA 4G3HA 1P8PA 3M1RA 1GQ7A 2AEBA 4GSMA 1WOIA 3MMRA 3DJ8A 4HZEA 1HQXA 3THEA 4IE3A 4IU0A 3KV2A 1R1OA 5HJ9A 2EIVA 5HJAA 3TF3A 1T4TA 3SL1A 1WOGA 4RHQA 1PQ3A 4Q3PA 3NIPA 3THHA 4Q42A 4Q41A 3GMZA 4GSZA 4MYKA 3NIQA 3F80A 3LHLA 4IXVA 2RLAA 1TBJA 1HQGA 4MYNA 3CEVA 4CEVA 1ZPGA 3RLAA 3MFWA 3THJA 1T4PA 1CEVA 4RHIA 2PHOA 1WVAA 3TH7A 4IU1A 4IXUA 2PHAA 1P8NA 4RHMA 1P8RA 4HXQA 4MYFA 4DZ4A 1RLAA 3LP7A 3E6KA 1P8OA 3SKKA 4FCIA 2EF5A 4FCKA 5RLAA 1HQ5A 3LP4A 2PLLA 2A0MA 1P8MA 4GSVA 4I06A 4RHLA 3E8QA 1T5FA 1TBLA 4RHJA 3E6VA 4Q3UA 3NIOA 3E8ZA 1T4SA 1P8SA 4MYLA 4Q3RC 1ZPEA 4MXRA 1HQHA 4HWWA 4Q3RA 1HQFA 1WOHA 2EF4A 3MJLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CEV A;  1GQ6 A;  3MFV A;  4RLA A;  4IU4 A;  1TBH A;  4ITY A;  1TA1 A;  4RHK A;  4IU5 A;  2ZAV A;  1P8Q A;  3GN0 A;  4Q40 A;  4Q3V A;  1XFK A;  3E9B A;  1T5G A;  4GWC A;  4Q3Q A;  3SL0 A;  4Q3S A;  1T4R A;  1WVB A;  2CEV A;  4IE2 A;  4GWD A;  4Q3T A;  1D3V A;  3SJT A;  4IE1 A;  3PZL A;  4G3H A;  1P8P A;  3M1R A;  1GQ7 A;  2AEB A;  4GSM A;  1WOI A;  3MMR A;  3DJ8 A;  4HZE A;  1HQX A;  3THE A;  4IE3 A;  4IU0 A;  3KV2 A;  1R1O A;  5HJ9 A;  2EIV A;  5HJA A;  3TF3 A;  1T4T A;  3SL1 A;  1WOG A;  4RHQ A;  1PQ3 A;  4Q3P A;  3NIP A;  3THH A;  4Q42 A;  4Q41 A;  3GMZ A;  4GSZ A;  4MYK A;  3NIQ A;  3F80 A;  3LHL A;  4IXV A;  2RLA A;  1TBJ A;  1HQG A;  4MYN A;  3CEV A;  4CEV A;  1ZPG A;  3RLA A;  3MFW A;  3THJ A;  1T4P A;  1CEV A;  4RHI A;  2PHO A;  1WVA A;  3TH7 A;  4IU1 A;  4IXU A;  2PHA A;  1P8N A;  4RHM A;  1P8R A;  4HXQ A;  4MYF A;  4DZ4 A;  1RLA A;  3LP7 A;  3E6K A;  1P8O A;  3SKK A;  4FCI A;  2EF5 A;  4FCK A;  5RLA A;  1HQ5 A;  3LP4 A;  2PLL A;  2A0M A;  1P8M A;  4GSV A;  4I06 A;  4RHL A;  3E8Q A;  1T5F A;  1TBL A;  4RHJ A;  3E6V A;  4Q3U A;  3NIO A;  3E8Z A;  1T4S A;  1P8S A;  4MYL A;  4Q3R C;  1ZPE A;  4MXR A;  1HQH A;  4HWW A;  4Q3R A;  1HQF A;  1WOH A;  2EF4 A;  3MJL A; 
#chains in the Genus database with same CATH topology
 5D1C A;  5CEV A;  1GQ6 A;  3MFV A;  5EEF A;  4RLA A;  5G1B A;  3Q9F A;  4IU4 A;  3MEN A;  1TBH A;  2VQJ A;  4ITY A;  1TA1 A;  2VQM A;  4BZ7 A;  4RHK A;  4IU5 A;  2VQQ A;  3SFF A;  3Q9B A;  5IWG A;  2ZAV A;  3MZ6 A;  1ZZ3 A;  1P8Q A;  4CBY A;  3GN0 A;  4Q40 A;  4Q3V A;  1XFK A;  3EZP A;  3E9B A;  1T5G A;  4GWC A;  3F0R A;  4Q3Q A;  5G12 A;  5G17 A;  4ZUP A;  4Q3S A;  3SL0 A;  1T4R A;  1WVB A;  2CEV A;  4IE2 A;  4GWD A;  5DC8 A;  5DC6 A;  4Q3T A;  4QA1 A;  2V5W A;  1D3V A;  5EF7 A;  3SJT A;  5G0J A;  4IE1 A;  3PZL A;  4G3H A;  1P8P A;  3M1R A;  5EEN A;  1GQ7 A;  2AEB A;  5LI3 A;  4GSM A;  1WOI A;  3MMR A;  3DJ8 A;  4HZE A;  5G11 A;  5THV A;  1HQX A;  5DC7 A;  3ZNR A;  3F06 A;  5EFH A;  3THE A;  4IE3 A;  5BWZ A;  3C0Y A;  5EFB D;  4IU0 A;  5EFG A;  4ZUQ A;  3KV2 A;  1R1O A;  5HJ9 A;  2EIV A;  2VQW G;  3EW8 A;  4BZ9 A;  5HJA A;  3TF3 A;  1T4T A;  3SL1 A;  1ZZ1 A;  5EFJ D;  5DC5 A;  5EEM A;  4BZ6 A;  4QA2 A;  5EEI A;  1WOG A;  1C3S A;  5THU A;  4RHQ A;  5THS A;  4BKX B;  3EWF A;  1PQ3 A;  4Q3P A;  3NIP A;  5IX0 A;  3THH A;  4Q42 A;  3SFH A;  5G1A A;  3GMZ A;  4Q41 A;  1C3P A;  4GSZ A;  5EF8 A;  4MYK A;  4ZUN A;  3F80 A;  3NIQ A;  3LHL A;  5G10 A;  4IXV A;  4BZ8 A;  3MAX A;  2RLA A;  4RN0 A;  4BZ5 A;  1TBJ A;  1T69 A;  2V5X A;  1HQG A;  1T64 A;  4MYN A;  3CEV A;  4CEV A;  1ZPG A;  3RLA A;  1VKG A;  3MFW A;  1W22 A;  5G13 A;  1T4P A;  1T67 A;  1CEV A;  3THJ A;  5A2S A;  4RHI A;  3ZNS A;  4A69 A;  5G1C A;  5THT A;  2PHO A;  4ZUO A;  4LXZ A;  1WVA A;  3TH7 A;  3F07 A;  3MZ7 A;  4IU1 A;  4ZUM A;  4IXU A;  2PHA A;  1P8N A;  4RHM A;  5G0I A;  1P8R A;  2GH6 A;  4HXQ A;  4ZUR A;  3Q9C A;  4MYF A;  4QA7 A;  4DZ4 A;  5EEK A;  1RLA A;  3LP7 A;  4QA6 A;  4RN1 A;  3E6K A;  1P8O A;  3SKK A;  5FUE A;  4FCI A;  2EF5 A;  4FCK A;  5EFN A;  4RN2 A;  3Q9E A;  4QA4 A;  5D1B A;  1WOH A;  5RLA A;  1HQ5 A;  3LP4 A;  5D1D A;  5G0G A;  4QA0 A;  3EZT A;  2PLL A;  3MZ4 A;  2A0M A;  4QA5 A;  1P8M A;  4CQF A;  4GSV A;  2VCG A;  4I06 A;  5G0Y A;  4RHL A;  3E8Q A;  1T5F A;  1TBL A;  4RHJ A;  3E6V A;  1C3R A;  4Q3U A;  3MZ3 A;  3C10 A;  5G0X A;  3RQD A;  3NIO A;  3E8Z A;  5JI5 A;  4LY1 A;  5G0H A;  1T4S A;  2VQV A;  5G3W A;  1P8S A;  4MYL A;  1ZZ0 A;  4Q3R C;  5EFK B;  4CBT A;  1ZPE A;  5ICN B;  4MXR A;  3C0Z A;  1HQH A;  5FCW A;  4HWW A;  4Q3R A;  1HQF A;  4QA3 A;  2VQO A;  2EF4 A;  3MJL A; 
#chains in the Genus database with same CATH homology
 5CEV A;  1GQ6 A;  3MFV A;  4RLA A;  4IU4 A;  1TBH A;  4ITY A;  1TA1 A;  4RHK A;  4IU5 A;  2ZAV A;  1P8Q A;  3GN0 A;  4Q40 A;  4Q3V A;  1XFK A;  3E9B A;  1T5G A;  4GWC A;  4Q3Q A;  3SL0 A;  4Q3S A;  1T4R A;  1WVB A;  2CEV A;  4IE2 A;  4GWD A;  4Q3T A;  1D3V A;  3SJT A;  4IE1 A;  3PZL A;  4G3H A;  1P8P A;  3M1R A;  1GQ7 A;  2AEB A;  4GSM A;  1WOI A;  3MMR A;  3DJ8 A;  4HZE A;  1HQX A;  3THE A;  4IE3 A;  4IU0 A;  3KV2 A;  1R1O A;  5HJ9 A;  2EIV A;  5HJA A;  3TF3 A;  1T4T A;  3SL1 A;  1WOG A;  4RHQ A;  1PQ3 A;  4Q3P A;  3NIP A;  3THH A;  4Q42 A;  4Q41 A;  3GMZ A;  4GSZ A;  4MYK A;  3NIQ A;  3F80 A;  3LHL A;  4IXV A;  2RLA A;  1TBJ A;  1HQG A;  4MYN A;  3CEV A;  4CEV A;  1ZPG A;  3RLA A;  3MFW A;  3THJ A;  1T4P A;  1CEV A;  4RHI A;  2PHO A;  1WVA A;  3TH7 A;  4IU1 A;  4IXU A;  2PHA A;  1P8N A;  4RHM A;  1P8R A;  4HXQ A;  4MYF A;  4DZ4 A;  1RLA A;  3LP7 A;  3E6K A;  1P8O A;  3SKK A;  4FCI A;  2EF5 A;  4FCK A;  5RLA A;  1HQ5 A;  3LP4 A;  2PLL A;  2A0M A;  1P8M A;  4GSV A;  4I06 A;  4RHL A;  3E8Q A;  1T5F A;  1TBL A;  4RHJ A;  3E6V A;  4Q3U A;  3NIO A;  3E8Z A;  1T4S A;  1P8S A;  4MYL A;  4Q3R C;  1ZPE A;  4MXR A;  1HQH A;  4HWW A;  4Q3R A;  1HQF A;  1WOH A;  2EF4 A;  3MJL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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