1HQXA

R308k arginase variant
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKKEGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
pubmed rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 112
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2000-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1hqxA00
1HQFA 4IE3A 3SL0A 4RLAA 4Q3RC 1CEVA 4Q3VA 1PQ3A 4FCIA 4IU0A 1R1OA 4DZ4A 1WVAA 1T4SA 4Q3RA 4RHMA 4HZEA 4Q3TA 2PLLA 4RHLA 4HWWA 3GMZA 3NIPA 4MYNA 4MYKA 1T5FA 1WVBA 4Q40A 1P8NA 4GWDA 4Q42A 2PHOA 1ZPGA 1ZPEA 4GSZA 1P8OA 5RLAA 3THHA 5CEVA 1TBLA 3NIOA 1GQ7A 1P8QA 1HQ5A 2EIVA 3DJ8A 1TBHA 3CEVA 3E6KA 3SL1A 3THEA 1TBJA 4GWCA 1D3VA 3E8QA 3F80A 2EF4A 2ZAVA 3MFWA 4IU5A 2AEBA 3GN0A 3M1RA 4ITYA 4RHQA 1T4PA 3TF3A 2CEVA 1WOGA 2PHAA 3MFVA 4Q41A 4IU1A 3MMRA 4Q3SA 3E8ZA 4GSMA 1T4RA 1P8RA 2EF5A 3TH7A 1T4TA 4RHIA 3KV2A 4CEVA 4Q3UA 4IE2A 1HQGA 3SJTA 1XFKA 4IXVA 4RHKA 2RLAA 3LHLA 1WOHA 1P8PA 4FCKA 3SKKA 4HXQA 1P8SA 4I06A 4Q3QA 3RLAA 1WOIA 4GSVA 3THJA 3LP4A 1GQ6A 1HQHA 1P8MA 4MYLA 5HJ9A 3E6VA 1RLAA 3PZLA 4IXUA 4MXRA 4RHJA 3LP7A 1HQXA 1T5GA 4MYFA 4Q3PA 3E9BA 2A0MA 4G3HA 1TA1A 4IE1A 5HJAA 4IU4A 3NIQA 3MJLA
chains in the Genus database with same CATH superfamily
1HQFA 4IE3A 3SL0A 3SFHA 5EFBD 5D1BA 3C0YA 4RLAA 4Q3RC 1CEVA 4Q3VA 1PQ3A 4FCIA 4ZURA 5THVA 5THUA 5EFJD 4IU0A 1C3SA 1R1OA 4BZ7A 3F07A 4DZ4A 1WVAA 4QA5A 1T4SA 4Q3RA 4RN2A 5EEFA 4RHMA 4HZEA 5DC8A 5G0JA 4Q3TA 2PLLA 4QA3A 3MZ7A 4RHLA 4HWWA 3GMZA 3NIPA 4MYNA 4BZ6A 3F06A 4MYKA 1W22A 1T5FA 5EEIA 5EEMA 2VQWG 1ZZ1A 1WVBA 4Q40A 3EWFA 1P8NA 4GWDA 4Q42A 2PHOA 1ZPGA 1ZPEA 3RQDA 4GSZA 5G10A 3MZ6A 5G17A 5FUEA 3MZ3A 2VCGA 5G1BA 1P8OA 5RLAA 3THHA 5CEVA 1TBLA 3NIOA 5A2SA 1T64A 1GQ7A 1P8QA 1HQ5A 1ZZ3A 4A69A 4BZ5A 3ZNSA 4ZUQA 3F0RA 2EIVA 5G0IA 3EW8A 5EENA 2V5WA 3DJ8A 5D1DA 1TBHA 3CEVA 3E6KA 3SL1A 3THEA 1TBJA 2VQJA 4GWCA 5EF7A 4QA4A 4ZUPA 1D3VA 3E8QA 4BZ8A 3F80A 4QA1A 4BKXB 2EF4A 2ZAVA 4RN0A 2VQOA 3MFWA 4IU5A 2AEBA 3GN0A 3M1RA 4ITYA 4RHQA 4QA7A 5G11A 1T4PA 5IWGA 5G0YA 2VQMA 3TF3A 2CEVA 5EEKA 5FCWA 1WOGA 2PHAA 3MFVA 4Q41A 4IU1A 3MMRA 4ZUMA 5G12A 4Q3SA 1ZZ0A 3E8ZA 4GSMA 1T4RA 1P8RA 3Q9FA 2EF5A 5EF8A 5EFNA 3TH7A 1T4TA 4RHIA 3Q9EA 3KV2A 5G0XA 5EFGA 4CEVA 4Q3UA 5THTA 1C3RA 4IE2A 1HQGA 3C0ZA 3SJTA 5IX0A 1VKGA 1XFKA 3SFFA 5LI3A 4IXVA 3MAXA 5ICNB 5G0HA 5D1CA 5BWZA 4RHKA 2RLAA 3LHLA 5G1CA 4ZUNA 1WOHA 4QA2A 5G3WA 3C10A 1P8PA 4FCKA 5G13A 4QA6A 3SKKA 2V5XA 4QA0A 4HXQA 5DC6A 4ZUOA 1P8SA 1C3PA 4I06A 4Q3QA 3RLAA 1WOIA 2VQVA 2GH6A 3MZ4A 4GSVA 5DC5A 3LP4A 5EFHA 3THJA 1GQ6A 4BZ9A 1HQHA 1P8MA 5EFKB 4MYLA 5HJ9A 3EZTA 3E6VA 1RLAA 3PZLA 4IXUA 4MXRA 3Q9CA 5G0GA 4RHJA 4CBYA 4LXZA 3ZNRA 3MENA 3LP7A 1T67A 3Q9BA 1HQXA 1T5GA 5THSA 3EZPA 4MYFA 4Q3PA 1T69A 4CQFA 5JI5A 3E9BA 4RN1A 2A0MA 5G1AA 4LY1A 4G3HA 1TA1A 4IE1A 2VQQA 5HJAA 4IU4A 4CBTA 3NIQA 3MJLA 5DC7A
chains in the Genus database with same CATH topology
1HQFA 4IE3A 3SL0A 4RLAA 4Q3RC 1CEVA 4Q3VA 1PQ3A 4FCIA 4IU0A 1R1OA 4DZ4A 1WVAA 1T4SA 4Q3RA 4RHMA 4HZEA 4Q3TA 2PLLA 4RHLA 4HWWA 3GMZA 3NIPA 4MYNA 4MYKA 1T5FA 1WVBA 4Q40A 1P8NA 4GWDA 4Q42A 2PHOA 1ZPGA 1ZPEA 4GSZA 1P8OA 5RLAA 3THHA 5CEVA 1TBLA 3NIOA 1GQ7A 1P8QA 1HQ5A 2EIVA 3DJ8A 1TBHA 3CEVA 3E6KA 3SL1A 3THEA 1TBJA 4GWCA 1D3VA 3E8QA 3F80A 2EF4A 2ZAVA 3MFWA 4IU5A 2AEBA 3GN0A 3M1RA 4ITYA 4RHQA 1T4PA 3TF3A 2CEVA 1WOGA 2PHAA 3MFVA 4Q41A 4IU1A 3MMRA 4Q3SA 3E8ZA 4GSMA 1T4RA 1P8RA 2EF5A 3TH7A 1T4TA 4RHIA 3KV2A 4CEVA 4Q3UA 4IE2A 1HQGA 3SJTA 1XFKA 4IXVA 4RHKA 2RLAA 3LHLA 1WOHA 1P8PA 4FCKA 3SKKA 4HXQA 1P8SA 4I06A 4Q3QA 3RLAA 1WOIA 4GSVA 3THJA 3LP4A 1GQ6A 1HQHA 1P8MA 4MYLA 5HJ9A 3E6VA 1RLAA 3PZLA 4IXUA 4MXRA 4RHJA 3LP7A 1HQXA 1T5GA 4MYFA 4Q3PA 3E9BA 2A0MA 4G3HA 1TA1A 4IE1A 5HJAA 4IU4A 3NIQA 3MJLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HQF A;  4IE3 A;  3SL0 A;  4RLA A;  4Q3R C;  1CEV A;  4Q3V A;  1PQ3 A;  4FCI A;  4IU0 A;  1R1O A;  4DZ4 A;  1WVA A;  1T4S A;  4Q3R A;  4RHM A;  4HZE A;  4Q3T A;  2PLL A;  4RHL A;  4HWW A;  3GMZ A;  3NIP A;  4MYN A;  4MYK A;  1T5F A;  1WVB A;  4Q40 A;  1P8N A;  4GWD A;  4Q42 A;  2PHO A;  1ZPG A;  1ZPE A;  4GSZ A;  1P8O A;  5RLA A;  3THH A;  5CEV A;  1TBL A;  3NIO A;  1GQ7 A;  1P8Q A;  1HQ5 A;  2EIV A;  3DJ8 A;  1TBH A;  3CEV A;  3E6K A;  3SL1 A;  3THE A;  1TBJ A;  4GWC A;  1D3V A;  3E8Q A;  3F80 A;  2EF4 A;  2ZAV A;  3MFW A;  4IU5 A;  2AEB A;  3GN0 A;  3M1R A;  4ITY A;  4RHQ A;  1T4P A;  3TF3 A;  2CEV A;  1WOG A;  2PHA A;  3MFV A;  4Q41 A;  4IU1 A;  3MMR A;  4Q3S A;  3E8Z A;  4GSM A;  1T4R A;  1P8R A;  2EF5 A;  3TH7 A;  1T4T A;  4RHI A;  3KV2 A;  4CEV A;  4Q3U A;  4IE2 A;  1HQG A;  3SJT A;  1XFK A;  4IXV A;  4RHK A;  2RLA A;  3LHL A;  1WOH A;  1P8P A;  4FCK A;  3SKK A;  4HXQ A;  1P8S A;  4I06 A;  4Q3Q A;  3RLA A;  1WOI A;  4GSV A;  3THJ A;  3LP4 A;  1GQ6 A;  1HQH A;  1P8M A;  4MYL A;  5HJ9 A;  3E6V A;  1RLA A;  3PZL A;  4IXU A;  4MXR A;  4RHJ A;  3LP7 A;  1HQX A;  1T5G A;  4MYF A;  4Q3P A;  3E9B A;  2A0M A;  4G3H A;  1TA1 A;  4IE1 A;  5HJA A;  4IU4 A;  3NIQ A;  3MJL A; 
#chains in the Genus database with same CATH topology
 1HQF A;  4IE3 A;  3SL0 A;  3SFH A;  5EFB D;  5D1B A;  3C0Y A;  4RLA A;  4Q3R C;  1CEV A;  4Q3V A;  1PQ3 A;  4FCI A;  4ZUR A;  5THV A;  5THU A;  5EFJ D;  4IU0 A;  1C3S A;  1R1O A;  4BZ7 A;  3F07 A;  4DZ4 A;  1WVA A;  4QA5 A;  1T4S A;  4Q3R A;  4RN2 A;  5EEF A;  4RHM A;  4HZE A;  5DC8 A;  5G0J A;  4Q3T A;  2PLL A;  4QA3 A;  3MZ7 A;  4RHL A;  4HWW A;  3GMZ A;  3NIP A;  4MYN A;  4BZ6 A;  3F06 A;  4MYK A;  1W22 A;  1T5F A;  5EEI A;  5EEM A;  2VQW G;  1ZZ1 A;  1WVB A;  4Q40 A;  3EWF A;  1P8N A;  4GWD A;  4Q42 A;  2PHO A;  1ZPG A;  1ZPE A;  3RQD A;  4GSZ A;  5G10 A;  3MZ6 A;  5G17 A;  5FUE A;  3MZ3 A;  2VCG A;  5G1B A;  1P8O A;  5RLA A;  3THH A;  5CEV A;  1TBL A;  3NIO A;  5A2S A;  1T64 A;  1GQ7 A;  1P8Q A;  1HQ5 A;  1ZZ3 A;  4A69 A;  4BZ5 A;  3ZNS A;  4ZUQ A;  3F0R A;  2EIV A;  5G0I A;  3EW8 A;  5EEN A;  2V5W A;  3DJ8 A;  5D1D A;  1TBH A;  3CEV A;  3E6K A;  3SL1 A;  3THE A;  1TBJ A;  2VQJ A;  4GWC A;  5EF7 A;  4QA4 A;  4ZUP A;  1D3V A;  3E8Q A;  4BZ8 A;  3F80 A;  4QA1 A;  4BKX B;  2EF4 A;  2ZAV A;  4RN0 A;  2VQO A;  3MFW A;  4IU5 A;  2AEB A;  3GN0 A;  3M1R A;  4ITY A;  4RHQ A;  4QA7 A;  5G11 A;  1T4P A;  5IWG A;  5G0Y A;  2VQM A;  3TF3 A;  2CEV A;  5EEK A;  5FCW A;  1WOG A;  2PHA A;  3MFV A;  4Q41 A;  4IU1 A;  3MMR A;  4ZUM A;  5G12 A;  4Q3S A;  1ZZ0 A;  3E8Z A;  4GSM A;  1T4R A;  1P8R A;  3Q9F A;  2EF5 A;  5EF8 A;  5EFN A;  3TH7 A;  1T4T A;  4RHI A;  3Q9E A;  3KV2 A;  5G0X A;  5EFG A;  4CEV A;  4Q3U A;  5THT A;  1C3R A;  4IE2 A;  1HQG A;  3C0Z A;  3SJT A;  5IX0 A;  1VKG A;  1XFK A;  3SFF A;  5LI3 A;  4IXV A;  3MAX A;  5ICN B;  5G0H A;  5D1C A;  5BWZ A;  4RHK A;  2RLA A;  3LHL A;  5G1C A;  4ZUN A;  1WOH A;  4QA2 A;  5G3W A;  3C10 A;  1P8P A;  4FCK A;  5G13 A;  4QA6 A;  3SKK A;  2V5X A;  4QA0 A;  4HXQ A;  5DC6 A;  4ZUO A;  1P8S A;  1C3P A;  4I06 A;  4Q3Q A;  3RLA A;  1WOI A;  2VQV A;  2GH6 A;  3MZ4 A;  4GSV A;  5DC5 A;  3LP4 A;  5EFH A;  3THJ A;  1GQ6 A;  4BZ9 A;  1HQH A;  1P8M A;  5EFK B;  4MYL A;  5HJ9 A;  3EZT A;  3E6V A;  1RLA A;  3PZL A;  4IXU A;  4MXR A;  3Q9C A;  5G0G A;  4RHJ A;  4CBY A;  4LXZ A;  3ZNR A;  3MEN A;  3LP7 A;  1T67 A;  3Q9B A;  1HQX A;  1T5G A;  5THS A;  3EZP A;  4MYF A;  4Q3P A;  1T69 A;  4CQF A;  5JI5 A;  3E9B A;  4RN1 A;  2A0M A;  5G1A A;  4LY1 A;  4G3H A;  1TA1 A;  4IE1 A;  2VQQ A;  5HJA A;  4IU4 A;  4CBT A;  3NIQ A;  3MJL A;  5DC7 A; 
#chains in the Genus database with same CATH homology
 1HQF A;  4IE3 A;  3SL0 A;  4RLA A;  4Q3R C;  1CEV A;  4Q3V A;  1PQ3 A;  4FCI A;  4IU0 A;  1R1O A;  4DZ4 A;  1WVA A;  1T4S A;  4Q3R A;  4RHM A;  4HZE A;  4Q3T A;  2PLL A;  4RHL A;  4HWW A;  3GMZ A;  3NIP A;  4MYN A;  4MYK A;  1T5F A;  1WVB A;  4Q40 A;  1P8N A;  4GWD A;  4Q42 A;  2PHO A;  1ZPG A;  1ZPE A;  4GSZ A;  1P8O A;  5RLA A;  3THH A;  5CEV A;  1TBL A;  3NIO A;  1GQ7 A;  1P8Q A;  1HQ5 A;  2EIV A;  3DJ8 A;  1TBH A;  3CEV A;  3E6K A;  3SL1 A;  3THE A;  1TBJ A;  4GWC A;  1D3V A;  3E8Q A;  3F80 A;  2EF4 A;  2ZAV A;  3MFW A;  4IU5 A;  2AEB A;  3GN0 A;  3M1R A;  4ITY A;  4RHQ A;  1T4P A;  3TF3 A;  2CEV A;  1WOG A;  2PHA A;  3MFV A;  4Q41 A;  4IU1 A;  3MMR A;  4Q3S A;  3E8Z A;  4GSM A;  1T4R A;  1P8R A;  2EF5 A;  3TH7 A;  1T4T A;  4RHI A;  3KV2 A;  4CEV A;  4Q3U A;  4IE2 A;  1HQG A;  3SJT A;  1XFK A;  4IXV A;  4RHK A;  2RLA A;  3LHL A;  1WOH A;  1P8P A;  4FCK A;  3SKK A;  4HXQ A;  1P8S A;  4I06 A;  4Q3Q A;  3RLA A;  1WOI A;  4GSV A;  3THJ A;  3LP4 A;  1GQ6 A;  1HQH A;  1P8M A;  4MYL A;  5HJ9 A;  3E6V A;  1RLA A;  3PZL A;  4IXU A;  4MXR A;  4RHJ A;  3LP7 A;  1HQX A;  1T5G A;  4MYF A;  4Q3P A;  3E9B A;  2A0M A;  4G3H A;  1TA1 A;  4IE1 A;  5HJA A;  4IU4 A;  3NIQ A;  3MJL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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