1P8NA

Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase i.
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFAVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords Arginase 1
total genus 111
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2003-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1p8nA00
1T4SA 4RHJA 4HZEA 3E6KA 1TA1A 3NIPA 3SL0A 3KV2A 4RHQA 2AEBA 1T4TA 1T5GA 1WOHA 5RLAA 4RHLA 5CEVA 3RLAA 3MMRA 4Q3VA 4I06A 1WVAA 1T4PA 4Q3RA 4IE1A 1GQ6A 4IXVA 1PQ3A 3E8QA 1P8SA 3MFWA 1XFKA 3MFVA 3THJA 4GWCA 4HWWA 4CEVA 3F80A 2PHAA 4IE2A 4Q3UA 1P8NA 2PHOA 2A0MA 4Q40A 2RLAA 3GMZA 4FCIA 3CEVA 3SL1A 4IU1A 3MJLA 1HQ5A 3M1RA 3THEA 4Q3RC 1HQFA 4Q42A 5HJ9A 2EIVA 1TBLA 1T4RA 3SKKA 1WOGA 2CEVA 4Q3SA 4IXUA 1WVBA 4IU0A 1P8PA 4IU5A 3LP4A 4DZ4A 1CEVA 3THHA 1TBHA 3TH7A 4GSVA 1R1OA 5HJAA 3LP7A 4IU4A 4Q3TA 1P8QA 3NIOA 1D3VA 3LHLA 4Q41A 1P8MA 3SJTA 1ZPEA 4IE3A 1P8OA 1HQHA 3E9BA 4GSMA 4FCKA 1ZPGA 2PLLA 1WOIA 3PZLA 4MYFA 3TF3A 4G3HA 4Q3PA 4GSZA 1HQXA 4RHKA 3NIQA 3E8ZA 2EF5A 1RLAA 4RLAA 1TBJA 2ZAVA 2EF4A 4RHIA 1GQ7A 4ITYA 4GWDA 1HQGA 3DJ8A 4MYKA 4Q3QA 4HXQA 4MYLA 3E6VA 4RHMA 3GN0A 4MYNA 1T5FA 1P8RA 4MXRA
chains in the Genus database with same CATH superfamily
1T4SA 4ZUNA 5G0GA 4RHJA 1VKGA 4LY1A 3RQDA 3Q9BA 4HZEA 5DC8A 4QA7A 3E6KA 1TA1A 5G10A 1C3SA 3NIPA 3SL0A 3KV2A 4RHQA 2AEBA 1T4TA 1T5GA 1WOHA 5D1CA 5RLAA 3MAXA 5IWGA 4RHLA 4QA4A 1C3RA 3MENA 4CBYA 3RLAA 5CEVA 4QA2A 3MMRA 1T67A 5EF8A 5G0HA 3SFFA 4RN0A 4Q3VA 4I06A 5DC6A 5EF7A 1WVAA 1T4PA 5THTA 4Q3RA 4ZUOA 4IE1A 1GQ6A 4IXVA 1PQ3A 4BZ5A 3E8QA 4CBTA 1P8SA 3F06A 4QA5A 3MFWA 1XFKA 3MFVA 5THVA 3C0YA 4ZURA 3THJA 4GWCA 1W22A 4HWWA 4CEVA 3C0ZA 5EFBD 3F80A 2PHAA 4IE2A 2VQMA 4Q3UA 1P8NA 2PHOA 2GH6A 2A0MA 5DC5A 4Q40A 5LI3A 2RLAA 3GMZA 4FCIA 3CEVA 4RN2A 3SL1A 5A2SA 4IU1A 5G0IA 4QA3A 3MJLA 4LXZA 5EFKB 5G3WA 1HQ5A 1ZZ1A 3M1RA 4Q3RC 4QA6A 1HQFA 4Q42A 3THEA 5EEFA 3ZNSA 5HJ9A 3EW8A 2EIVA 4ZUPA 1TBLA 3EZPA 5EEKA 1T4RA 3SKKA 1WOGA 2VQOA 5G0JA 3Q9CA 2CEVA 4Q3SA 5THUA 4IXUA 4BZ8A 1WVBA 5FUEA 4IU0A 5G1CA 5JI5A 5G13A 5BWZA 1P8PA 5EEMA 3F0RA 3LP4A 4IU5A 5IX0A 4DZ4A 1CEVA 3THHA 1TBHA 5EFNA 5G1BA 3TH7A 1T69A 4GSVA 1R1OA 3ZNRA 5HJAA 3LP7A 3Q9FA 4IU4A 4BKXB 4Q3TA 1P8QA 4ZUQA 2VQJA 4BZ9A 4QA0A 5D1BA 3SFHA 1ZZ3A 2V5XA 2VQWG 5EFGA 3NIOA 1D3VA 2V5WA 5EEIA 2VQVA 3LHLA 3MZ3A 4Q41A 1P8MA 3C10A 5G12A 3SJTA 1ZPEA 4IE3A 1P8OA 5G1AA 1HQHA 1ZZ0A 3E9BA 3MZ7A 4GSMA 4ZUMA 4QA1A 4FCKA 1ZPGA 4A69A 4RN1A 2PLLA 5FCWA 1C3PA 5THSA 1WOIA 3MZ6A 3PZLA 4MYFA 3TF3A 3EZTA 4G3HA 4Q3PA 5EFHA 5G17A 3F07A 4BZ6A 4GSZA 1HQXA 4RHKA 3NIQA 3E8ZA 2EF5A 1T64A 3EWFA 5DC7A 1RLAA 4RLAA 1TBJA 2ZAVA 2EF4A 4RHIA 4CQFA 1GQ7A 5EFJD 2VCGA 4ITYA 4BZ7A 4GWDA 1HQGA 3DJ8A 3Q9EA 3MZ4A 2VQQA 5G0YA 4MYKA 4Q3QA 4HXQA 4MYLA 5ICNB 3E6VA 4RHMA 3GN0A 4MYNA 5D1DA 5G0XA 1T5FA 1P8RA 5EENA 4MXRA 5G11A
chains in the Genus database with same CATH topology
1T4SA 4RHJA 4HZEA 3E6KA 1TA1A 3NIPA 3SL0A 3KV2A 4RHQA 2AEBA 1T4TA 1T5GA 1WOHA 5RLAA 4RHLA 5CEVA 3RLAA 3MMRA 4Q3VA 4I06A 1WVAA 1T4PA 4Q3RA 4IE1A 1GQ6A 4IXVA 1PQ3A 3E8QA 1P8SA 3MFWA 1XFKA 3MFVA 3THJA 4GWCA 4HWWA 4CEVA 3F80A 2PHAA 4IE2A 4Q3UA 1P8NA 2PHOA 2A0MA 4Q40A 2RLAA 3GMZA 4FCIA 3CEVA 3SL1A 4IU1A 3MJLA 1HQ5A 3M1RA 3THEA 4Q3RC 1HQFA 4Q42A 5HJ9A 2EIVA 1TBLA 1T4RA 3SKKA 1WOGA 2CEVA 4Q3SA 4IXUA 1WVBA 4IU0A 1P8PA 4IU5A 3LP4A 4DZ4A 1CEVA 3THHA 1TBHA 3TH7A 4GSVA 1R1OA 5HJAA 3LP7A 4IU4A 4Q3TA 1P8QA 3NIOA 1D3VA 3LHLA 4Q41A 1P8MA 3SJTA 1ZPEA 4IE3A 1P8OA 1HQHA 3E9BA 4GSMA 4FCKA 1ZPGA 2PLLA 1WOIA 3PZLA 4MYFA 3TF3A 4G3HA 4Q3PA 4GSZA 1HQXA 4RHKA 3NIQA 3E8ZA 2EF5A 1RLAA 4RLAA 1TBJA 2ZAVA 2EF4A 4RHIA 1GQ7A 4ITYA 4GWDA 1HQGA 3DJ8A 4MYKA 4Q3QA 4HXQA 4MYLA 3E6VA 4RHMA 3GN0A 4MYNA 1T5FA 1P8RA 4MXRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T4S A;  4RHJ A;  4HZE A;  3E6K A;  1TA1 A;  3NIP A;  3SL0 A;  3KV2 A;  4RHQ A;  2AEB A;  1T4T A;  1T5G A;  1WOH A;  5RLA A;  4RHL A;  5CEV A;  3RLA A;  3MMR A;  4Q3V A;  4I06 A;  1WVA A;  1T4P A;  4Q3R A;  4IE1 A;  1GQ6 A;  4IXV A;  1PQ3 A;  3E8Q A;  1P8S A;  3MFW A;  1XFK A;  3MFV A;  3THJ A;  4GWC A;  4HWW A;  4CEV A;  3F80 A;  2PHA A;  4IE2 A;  4Q3U A;  1P8N A;  2PHO A;  2A0M A;  4Q40 A;  2RLA A;  3GMZ A;  4FCI A;  3CEV A;  3SL1 A;  4IU1 A;  3MJL A;  1HQ5 A;  3M1R A;  3THE A;  4Q3R C;  1HQF A;  4Q42 A;  5HJ9 A;  2EIV A;  1TBL A;  1T4R A;  3SKK A;  1WOG A;  2CEV A;  4Q3S A;  4IXU A;  1WVB A;  4IU0 A;  1P8P A;  4IU5 A;  3LP4 A;  4DZ4 A;  1CEV A;  3THH A;  1TBH A;  3TH7 A;  4GSV A;  1R1O A;  5HJA A;  3LP7 A;  4IU4 A;  4Q3T A;  1P8Q A;  3NIO A;  1D3V A;  3LHL A;  4Q41 A;  1P8M A;  3SJT A;  1ZPE A;  4IE3 A;  1P8O A;  1HQH A;  3E9B A;  4GSM A;  4FCK A;  1ZPG A;  2PLL A;  1WOI A;  3PZL A;  4MYF A;  3TF3 A;  4G3H A;  4Q3P A;  4GSZ A;  1HQX A;  4RHK A;  3NIQ A;  3E8Z A;  2EF5 A;  1RLA A;  4RLA A;  1TBJ A;  2ZAV A;  2EF4 A;  4RHI A;  1GQ7 A;  4ITY A;  4GWD A;  1HQG A;  3DJ8 A;  4MYK A;  4Q3Q A;  4HXQ A;  4MYL A;  3E6V A;  4RHM A;  3GN0 A;  4MYN A;  1T5F A;  1P8R A;  4MXR A; 
#chains in the Genus database with same CATH topology
 1T4S A;  4ZUN A;  5G0G A;  4RHJ A;  1VKG A;  4LY1 A;  3RQD A;  3Q9B A;  4HZE A;  5DC8 A;  4QA7 A;  3E6K A;  1TA1 A;  5G10 A;  1C3S A;  3NIP A;  3SL0 A;  3KV2 A;  4RHQ A;  2AEB A;  1T4T A;  1T5G A;  1WOH A;  5D1C A;  5RLA A;  3MAX A;  5IWG A;  4RHL A;  4QA4 A;  1C3R A;  3MEN A;  4CBY A;  3RLA A;  5CEV A;  4QA2 A;  3MMR A;  1T67 A;  5EF8 A;  5G0H A;  3SFF A;  4RN0 A;  4Q3V A;  4I06 A;  5DC6 A;  5EF7 A;  1WVA A;  1T4P A;  5THT A;  4Q3R A;  4ZUO A;  4IE1 A;  1GQ6 A;  4IXV A;  1PQ3 A;  4BZ5 A;  3E8Q A;  4CBT A;  1P8S A;  3F06 A;  4QA5 A;  3MFW A;  1XFK A;  3MFV A;  5THV A;  3C0Y A;  4ZUR A;  3THJ A;  4GWC A;  1W22 A;  4HWW A;  4CEV A;  3C0Z A;  5EFB D;  3F80 A;  2PHA A;  4IE2 A;  2VQM A;  4Q3U A;  1P8N A;  2PHO A;  2GH6 A;  2A0M A;  5DC5 A;  4Q40 A;  5LI3 A;  2RLA A;  3GMZ A;  4FCI A;  3CEV A;  4RN2 A;  3SL1 A;  5A2S A;  4IU1 A;  5G0I A;  4QA3 A;  3MJL A;  4LXZ A;  5EFK B;  5G3W A;  1HQ5 A;  1ZZ1 A;  3M1R A;  4Q3R C;  4QA6 A;  1HQF A;  4Q42 A;  3THE A;  5EEF A;  3ZNS A;  5HJ9 A;  3EW8 A;  2EIV A;  4ZUP A;  1TBL A;  3EZP A;  5EEK A;  1T4R A;  3SKK A;  1WOG A;  2VQO A;  5G0J A;  3Q9C A;  2CEV A;  4Q3S A;  5THU A;  4IXU A;  4BZ8 A;  1WVB A;  5FUE A;  4IU0 A;  5G1C A;  5JI5 A;  5G13 A;  5BWZ A;  1P8P A;  5EEM A;  3F0R A;  3LP4 A;  4IU5 A;  5IX0 A;  4DZ4 A;  1CEV A;  3THH A;  1TBH A;  5EFN A;  5G1B A;  3TH7 A;  1T69 A;  4GSV A;  1R1O A;  3ZNR A;  5HJA A;  3LP7 A;  3Q9F A;  4IU4 A;  4BKX B;  4Q3T A;  1P8Q A;  4ZUQ A;  2VQJ A;  4BZ9 A;  4QA0 A;  5D1B A;  3SFH A;  1ZZ3 A;  2V5X A;  2VQW G;  5EFG A;  3NIO A;  1D3V A;  2V5W A;  5EEI A;  2VQV A;  3LHL A;  3MZ3 A;  4Q41 A;  1P8M A;  3C10 A;  5G12 A;  3SJT A;  1ZPE A;  4IE3 A;  1P8O A;  5G1A A;  1HQH A;  1ZZ0 A;  3E9B A;  3MZ7 A;  4GSM A;  4ZUM A;  4QA1 A;  4FCK A;  1ZPG A;  4A69 A;  4RN1 A;  2PLL A;  5FCW A;  1C3P A;  5THS A;  1WOI A;  3MZ6 A;  3PZL A;  4MYF A;  3TF3 A;  3EZT A;  4G3H A;  4Q3P A;  5EFH A;  5G17 A;  3F07 A;  4BZ6 A;  4GSZ A;  1HQX A;  4RHK A;  3NIQ A;  3E8Z A;  2EF5 A;  1T64 A;  3EWF A;  5DC7 A;  1RLA A;  4RLA A;  1TBJ A;  2ZAV A;  2EF4 A;  4RHI A;  4CQF A;  1GQ7 A;  5EFJ D;  2VCG A;  4ITY A;  4BZ7 A;  4GWD A;  1HQG A;  3DJ8 A;  3Q9E A;  3MZ4 A;  2VQQ A;  5G0Y A;  4MYK A;  4Q3Q A;  4HXQ A;  4MYL A;  5ICN B;  3E6V A;  4RHM A;  3GN0 A;  4MYN A;  5D1D A;  5G0X A;  1T5F A;  1P8R A;  5EEN A;  4MXR A;  5G11 A; 
#chains in the Genus database with same CATH homology
 1T4S A;  4RHJ A;  4HZE A;  3E6K A;  1TA1 A;  3NIP A;  3SL0 A;  3KV2 A;  4RHQ A;  2AEB A;  1T4T A;  1T5G A;  1WOH A;  5RLA A;  4RHL A;  5CEV A;  3RLA A;  3MMR A;  4Q3V A;  4I06 A;  1WVA A;  1T4P A;  4Q3R A;  4IE1 A;  1GQ6 A;  4IXV A;  1PQ3 A;  3E8Q A;  1P8S A;  3MFW A;  1XFK A;  3MFV A;  3THJ A;  4GWC A;  4HWW A;  4CEV A;  3F80 A;  2PHA A;  4IE2 A;  4Q3U A;  1P8N A;  2PHO A;  2A0M A;  4Q40 A;  2RLA A;  3GMZ A;  4FCI A;  3CEV A;  3SL1 A;  4IU1 A;  3MJL A;  1HQ5 A;  3M1R A;  3THE A;  4Q3R C;  1HQF A;  4Q42 A;  5HJ9 A;  2EIV A;  1TBL A;  1T4R A;  3SKK A;  1WOG A;  2CEV A;  4Q3S A;  4IXU A;  1WVB A;  4IU0 A;  1P8P A;  4IU5 A;  3LP4 A;  4DZ4 A;  1CEV A;  3THH A;  1TBH A;  3TH7 A;  4GSV A;  1R1O A;  5HJA A;  3LP7 A;  4IU4 A;  4Q3T A;  1P8Q A;  3NIO A;  1D3V A;  3LHL A;  4Q41 A;  1P8M A;  3SJT A;  1ZPE A;  4IE3 A;  1P8O A;  1HQH A;  3E9B A;  4GSM A;  4FCK A;  1ZPG A;  2PLL A;  1WOI A;  3PZL A;  4MYF A;  3TF3 A;  4G3H A;  4Q3P A;  4GSZ A;  1HQX A;  4RHK A;  3NIQ A;  3E8Z A;  2EF5 A;  1RLA A;  4RLA A;  1TBJ A;  2ZAV A;  2EF4 A;  4RHI A;  1GQ7 A;  4ITY A;  4GWD A;  1HQG A;  3DJ8 A;  4MYK A;  4Q3Q A;  4HXQ A;  4MYL A;  3E6V A;  4RHM A;  3GN0 A;  4MYN A;  1T5F A;  1P8R A;  4MXR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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