1P8SA

Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase i.
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFCVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords Arginase 1
total genus 101
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2003-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1p8sA00
1GQ6A 3THHA 2PLLA 3MMRA 4FCKA 2A0MA 1WOGA 1T5FA 4Q42A 1WOIA 4HWWA 4GWCA 1GQ7A 4HXQA 4RHKA 3SJTA 1CEVA 2EIVA 1D3VA 3LP4A 1WVAA 4GSVA 1T4SA 3TF3A 3LP7A 4MYNA 4Q41A 4RHIA 3GN0A 1HQHA 2PHOA 3KV2A 4RHQA 1P8OA 3TH7A 4IU4A 1P8PA 2CEVA 2AEBA 1WVBA 2ZAVA 4Q3RC 3GMZA 3PZLA 3NIOA 1PQ3A 3CEVA 1P8SA 4MYFA 5HJ9A 4IE3A 4IE1A 1TBLA 3E9BA 3MFWA 4Q3VA 3NIQA 1T4RA 1WOHA 4RHLA 1T4PA 3SL0A 1HQXA 4I06A 4Q3UA 1P8QA 1HQ5A 1HQFA 1TBHA 4G3HA 3MFVA 4IXUA 1ZPGA 3NIPA 4MYKA 2RLAA 1P8RA 1T4TA 4IU1A 4Q40A 2PHAA 5HJAA 2EF4A 3M1RA 5RLAA 4GWDA 1P8NA 3E8ZA 4Q3RA 4RHJA 3THEA 3MJLA 4ITYA 4GSZA 4Q3PA 1XFKA 3SKKA 4FCIA 4GSMA 3SL1A 3F80A 3E8QA 3E6KA 4Q3QA 4DZ4A 4MXRA 3RLAA 3LHLA 1T5GA 1HQGA 1TA1A 4RLAA 2EF5A 4RHMA 3THJA 1ZPEA 4Q3SA 4IU0A 1RLAA 4IU5A 1P8MA 4CEVA 4MYLA 4HZEA 1TBJA 4IE2A 4IXVA 1R1OA 5CEVA 3DJ8A 4Q3TA 3E6VA
chains in the Genus database with same CATH superfamily
1GQ6A 3THHA 3EWFA 5JI5A 2PLLA 5G13A 5G1BA 3MMRA 3MZ6A 4FCKA 5EFBD 4ZUMA 2A0MA 1WOGA 1T5FA 4Q42A 5FUEA 3C0YA 1WOIA 3RQDA 5EENA 4HWWA 4GWCA 2VQJA 1GQ7A 5G12A 4QA1A 5IX0A 5A2SA 1T67A 4HXQA 3Q9CA 4CBTA 4RHKA 4LXZA 3SJTA 5G3WA 1CEVA 2EIVA 3C10A 1D3VA 3ZNRA 3LP4A 1WVAA 4BZ8A 4GSVA 1T4SA 3TF3A 4QA5A 3F07A 3LP7A 5EEKA 4MYNA 4QA3A 4Q41A 4RHIA 4CQFA 5EF8A 5EEIA 4QA2A 3GN0A 1HQHA 2PHOA 3KV2A 4RHQA 3MAXA 2VQQA 2VQOA 3Q9BA 1P8OA 3TH7A 4IU4A 1P8PA 3EZPA 2CEVA 2AEBA 1WVBA 4A69A 2ZAVA 4Q3RC 3GMZA 5ICNB 3PZLA 3NIOA 1PQ3A 3F0RA 5THTA 3CEVA 1P8SA 4ZUOA 4RN0A 4MYFA 5HJ9A 4IE3A 4IE1A 1TBLA 3E9BA 3MFWA 5EFHA 4Q3VA 2GH6A 3MZ7A 5EEMA 5G0HA 4ZUQA 3NIQA 1T4RA 1WOHA 4RHLA 4RN2A 3SFHA 4QA4A 1T4PA 5G0XA 1C3PA 5EFJD 3SL0A 5G17A 5EFKB 5G0JA 1HQXA 4I06A 4Q3UA 4BZ9A 5EFGA 1P8QA 5EEFA 1HQ5A 1HQFA 1TBHA 4ZUPA 4G3HA 3MFVA 4IXUA 1ZPGA 5THUA 3NIPA 4MYKA 4RN1A 2VQWG 3Q9EA 4BKXB 2RLAA 5EF7A 3SFFA 1P8RA 1T4TA 2VCGA 4IU1A 5G0YA 1W22A 2PHAA 4Q40A 5HJAA 1T69A 2EF4A 3M1RA 5RLAA 4GWDA 1P8NA 3E8ZA 4Q3RA 4RHJA 5LI3A 4BZ5A 5G0GA 5D1CA 5D1DA 3MJLA 4ITYA 4GSZA 4QA0A 3THEA 5EFNA 4Q3PA 1ZZ1A 4LY1A 1XFKA 5G11A 5G1AA 3SKKA 4FCIA 5BWZA 3C0ZA 4GSMA 3ZNSA 2V5XA 3SL1A 4BZ7A 3F80A 5DC8A 1T64A 3E8QA 3E6KA 5G0IA 3EW8A 4Q3QA 4DZ4A 4MXRA 5DC5A 3LHLA 3RLAA 1VKGA 1C3SA 2V5WA 1T5GA 1HQGA 1ZZ3A 5G10A 3MENA 5IWGA 1TA1A 5FCWA 4ZUNA 4RLAA 2EF5A 4RHMA 5THSA 3THJA 3MZ3A 5G1CA 1ZPEA 4Q3SA 4CBYA 3F06A 3Q9FA 2VQVA 4IU0A 5DC7A 1RLAA 4IU5A 1P8MA 4QA6A 4BZ6A 1C3RA 2VQMA 3MZ4A 5THVA 4CEVA 1ZZ0A 4HZEA 1TBJA 4IE2A 4IXVA 4MYLA 4ZURA 1R1OA 3EZTA 5CEVA 3DJ8A 5D1BA 4Q3TA 5DC6A 4QA7A 3E6VA
chains in the Genus database with same CATH topology
1GQ6A 3THHA 2PLLA 3MMRA 4FCKA 2A0MA 1WOGA 1T5FA 4Q42A 1WOIA 4HWWA 4GWCA 1GQ7A 4HXQA 4RHKA 3SJTA 1CEVA 2EIVA 1D3VA 3LP4A 1WVAA 4GSVA 1T4SA 3TF3A 3LP7A 4MYNA 4Q41A 4RHIA 3GN0A 1HQHA 2PHOA 3KV2A 4RHQA 1P8OA 3TH7A 4IU4A 1P8PA 2CEVA 2AEBA 1WVBA 2ZAVA 4Q3RC 3GMZA 3PZLA 3NIOA 1PQ3A 3CEVA 1P8SA 4MYFA 5HJ9A 4IE3A 4IE1A 1TBLA 3E9BA 3MFWA 4Q3VA 3NIQA 1T4RA 1WOHA 4RHLA 1T4PA 3SL0A 1HQXA 4I06A 4Q3UA 1P8QA 1HQ5A 1HQFA 1TBHA 4G3HA 3MFVA 4IXUA 1ZPGA 3NIPA 4MYKA 2RLAA 1P8RA 1T4TA 4IU1A 4Q40A 2PHAA 5HJAA 2EF4A 3M1RA 5RLAA 4GWDA 1P8NA 3E8ZA 4Q3RA 4RHJA 3THEA 3MJLA 4ITYA 4GSZA 4Q3PA 1XFKA 3SKKA 4FCIA 4GSMA 3SL1A 3F80A 3E8QA 3E6KA 4Q3QA 4DZ4A 4MXRA 3RLAA 3LHLA 1T5GA 1HQGA 1TA1A 4RLAA 2EF5A 4RHMA 3THJA 1ZPEA 4Q3SA 4IU0A 1RLAA 4IU5A 1P8MA 4CEVA 4MYLA 4HZEA 1TBJA 4IE2A 4IXVA 1R1OA 5CEVA 3DJ8A 4Q3TA 3E6VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GQ6 A;  3THH A;  2PLL A;  3MMR A;  4FCK A;  2A0M A;  1WOG A;  1T5F A;  4Q42 A;  1WOI A;  4HWW A;  4GWC A;  1GQ7 A;  4HXQ A;  4RHK A;  3SJT A;  1CEV A;  2EIV A;  1D3V A;  3LP4 A;  1WVA A;  4GSV A;  1T4S A;  3TF3 A;  3LP7 A;  4MYN A;  4Q41 A;  4RHI A;  3GN0 A;  1HQH A;  2PHO A;  3KV2 A;  4RHQ A;  1P8O A;  3TH7 A;  4IU4 A;  1P8P A;  2CEV A;  2AEB A;  1WVB A;  2ZAV A;  4Q3R C;  3GMZ A;  3PZL A;  3NIO A;  1PQ3 A;  3CEV A;  1P8S A;  4MYF A;  5HJ9 A;  4IE3 A;  4IE1 A;  1TBL A;  3E9B A;  3MFW A;  4Q3V A;  3NIQ A;  1T4R A;  1WOH A;  4RHL A;  1T4P A;  3SL0 A;  1HQX A;  4I06 A;  4Q3U A;  1P8Q A;  1HQ5 A;  1HQF A;  1TBH A;  4G3H A;  3MFV A;  4IXU A;  1ZPG A;  3NIP A;  4MYK A;  2RLA A;  1P8R A;  1T4T A;  4IU1 A;  4Q40 A;  2PHA A;  5HJA A;  2EF4 A;  3M1R A;  5RLA A;  4GWD A;  1P8N A;  3E8Z A;  4Q3R A;  4RHJ A;  3THE A;  3MJL A;  4ITY A;  4GSZ A;  4Q3P A;  1XFK A;  3SKK A;  4FCI A;  4GSM A;  3SL1 A;  3F80 A;  3E8Q A;  3E6K A;  4Q3Q A;  4DZ4 A;  4MXR A;  3RLA A;  3LHL A;  1T5G A;  1HQG A;  1TA1 A;  4RLA A;  2EF5 A;  4RHM A;  3THJ A;  1ZPE A;  4Q3S A;  4IU0 A;  1RLA A;  4IU5 A;  1P8M A;  4CEV A;  4MYL A;  4HZE A;  1TBJ A;  4IE2 A;  4IXV A;  1R1O A;  5CEV A;  3DJ8 A;  4Q3T A;  3E6V A; 
#chains in the Genus database with same CATH topology
 1GQ6 A;  3THH A;  3EWF A;  5JI5 A;  2PLL A;  5G13 A;  5G1B A;  3MMR A;  3MZ6 A;  4FCK A;  5EFB D;  4ZUM A;  2A0M A;  1WOG A;  1T5F A;  4Q42 A;  5FUE A;  3C0Y A;  1WOI A;  3RQD A;  5EEN A;  4HWW A;  4GWC A;  2VQJ A;  1GQ7 A;  5G12 A;  4QA1 A;  5IX0 A;  5A2S A;  1T67 A;  4HXQ A;  3Q9C A;  4CBT A;  4RHK A;  4LXZ A;  3SJT A;  5G3W A;  1CEV A;  2EIV A;  3C10 A;  1D3V A;  3ZNR A;  3LP4 A;  1WVA A;  4BZ8 A;  4GSV A;  1T4S A;  3TF3 A;  4QA5 A;  3F07 A;  3LP7 A;  5EEK A;  4MYN A;  4QA3 A;  4Q41 A;  4RHI A;  4CQF A;  5EF8 A;  5EEI A;  4QA2 A;  3GN0 A;  1HQH A;  2PHO A;  3KV2 A;  4RHQ A;  3MAX A;  2VQQ A;  2VQO A;  3Q9B A;  1P8O A;  3TH7 A;  4IU4 A;  1P8P A;  3EZP A;  2CEV A;  2AEB A;  1WVB A;  4A69 A;  2ZAV A;  4Q3R C;  3GMZ A;  5ICN B;  3PZL A;  3NIO A;  1PQ3 A;  3F0R A;  5THT A;  3CEV A;  1P8S A;  4ZUO A;  4RN0 A;  4MYF A;  5HJ9 A;  4IE3 A;  4IE1 A;  1TBL A;  3E9B A;  3MFW A;  5EFH A;  4Q3V A;  2GH6 A;  3MZ7 A;  5EEM A;  5G0H A;  4ZUQ A;  3NIQ A;  1T4R A;  1WOH A;  4RHL A;  4RN2 A;  3SFH A;  4QA4 A;  1T4P A;  5G0X A;  1C3P A;  5EFJ D;  3SL0 A;  5G17 A;  5EFK B;  5G0J A;  1HQX A;  4I06 A;  4Q3U A;  4BZ9 A;  5EFG A;  1P8Q A;  5EEF A;  1HQ5 A;  1HQF A;  1TBH A;  4ZUP A;  4G3H A;  3MFV A;  4IXU A;  1ZPG A;  5THU A;  3NIP A;  4MYK A;  4RN1 A;  2VQW G;  3Q9E A;  4BKX B;  2RLA A;  5EF7 A;  3SFF A;  1P8R A;  1T4T A;  2VCG A;  4IU1 A;  5G0Y A;  1W22 A;  2PHA A;  4Q40 A;  5HJA A;  1T69 A;  2EF4 A;  3M1R A;  5RLA A;  4GWD A;  1P8N A;  3E8Z A;  4Q3R A;  4RHJ A;  5LI3 A;  4BZ5 A;  5G0G A;  5D1C A;  5D1D A;  3MJL A;  4ITY A;  4GSZ A;  4QA0 A;  3THE A;  5EFN A;  4Q3P A;  1ZZ1 A;  4LY1 A;  1XFK A;  5G11 A;  5G1A A;  3SKK A;  4FCI A;  5BWZ A;  3C0Z A;  4GSM A;  3ZNS A;  2V5X A;  3SL1 A;  4BZ7 A;  3F80 A;  5DC8 A;  1T64 A;  3E8Q A;  3E6K A;  5G0I A;  3EW8 A;  4Q3Q A;  4DZ4 A;  4MXR A;  5DC5 A;  3LHL A;  3RLA A;  1VKG A;  1C3S A;  2V5W A;  1T5G A;  1HQG A;  1ZZ3 A;  5G10 A;  3MEN A;  5IWG A;  1TA1 A;  5FCW A;  4ZUN A;  4RLA A;  2EF5 A;  4RHM A;  5THS A;  3THJ A;  3MZ3 A;  5G1C A;  1ZPE A;  4Q3S A;  4CBY A;  3F06 A;  3Q9F A;  2VQV A;  4IU0 A;  5DC7 A;  1RLA A;  4IU5 A;  1P8M A;  4QA6 A;  4BZ6 A;  1C3R A;  2VQM A;  3MZ4 A;  5THV A;  4CEV A;  1ZZ0 A;  4HZE A;  1TBJ A;  4IE2 A;  4IXV A;  4MYL A;  4ZUR A;  1R1O A;  3EZT A;  5CEV A;  3DJ8 A;  5D1B A;  4Q3T A;  5DC6 A;  4QA7 A;  3E6V A; 
#chains in the Genus database with same CATH homology
 1GQ6 A;  3THH A;  2PLL A;  3MMR A;  4FCK A;  2A0M A;  1WOG A;  1T5F A;  4Q42 A;  1WOI A;  4HWW A;  4GWC A;  1GQ7 A;  4HXQ A;  4RHK A;  3SJT A;  1CEV A;  2EIV A;  1D3V A;  3LP4 A;  1WVA A;  4GSV A;  1T4S A;  3TF3 A;  3LP7 A;  4MYN A;  4Q41 A;  4RHI A;  3GN0 A;  1HQH A;  2PHO A;  3KV2 A;  4RHQ A;  1P8O A;  3TH7 A;  4IU4 A;  1P8P A;  2CEV A;  2AEB A;  1WVB A;  2ZAV A;  4Q3R C;  3GMZ A;  3PZL A;  3NIO A;  1PQ3 A;  3CEV A;  1P8S A;  4MYF A;  5HJ9 A;  4IE3 A;  4IE1 A;  1TBL A;  3E9B A;  3MFW A;  4Q3V A;  3NIQ A;  1T4R A;  1WOH A;  4RHL A;  1T4P A;  3SL0 A;  1HQX A;  4I06 A;  4Q3U A;  1P8Q A;  1HQ5 A;  1HQF A;  1TBH A;  4G3H A;  3MFV A;  4IXU A;  1ZPG A;  3NIP A;  4MYK A;  2RLA A;  1P8R A;  1T4T A;  4IU1 A;  4Q40 A;  2PHA A;  5HJA A;  2EF4 A;  3M1R A;  5RLA A;  4GWD A;  1P8N A;  3E8Z A;  4Q3R A;  4RHJ A;  3THE A;  3MJL A;  4ITY A;  4GSZ A;  4Q3P A;  1XFK A;  3SKK A;  4FCI A;  4GSM A;  3SL1 A;  3F80 A;  3E8Q A;  3E6K A;  4Q3Q A;  4DZ4 A;  4MXR A;  3RLA A;  3LHL A;  1T5G A;  1HQG A;  1TA1 A;  4RLA A;  2EF5 A;  4RHM A;  3THJ A;  1ZPE A;  4Q3S A;  4IU0 A;  1RLA A;  4IU5 A;  1P8M A;  4CEV A;  4MYL A;  4HZE A;  1TBJ A;  4IE2 A;  4IXV A;  1R1O A;  5CEV A;  3DJ8 A;  4Q3T A;  3E6V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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