1R1OA

Amino acid sulfonamides as transition-state analogue inhibitors of arginase
Total Genus 108
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (7-13)EMPTYO1 (13-15)TVIII1 (17-20)TIV3 (135-138)TI1 (16-19)AH1 (27-34)S2 (46-52)AH2 (36-42)AH9 (254-267)AH3 (70-90)TII'1 (64-67)TIV1 (63-66)S3 (93-98)S7 (227-232)AH4 (102-114)AH8 (208-220)TI2 (115-118)TIV7 (220-223)S4 (119-123)3H2 (140-142)TVIII2 (124-127)S5 (174-179)TI3 (131-134)TI4 (132-135)AH5 (143-148)TII2 (152-155)TIV4 (154-157)TII3 (159-162)TI7 (162-165)TI8 (170-173)S6 (196-199)AH7 (200-206)TI10 (233-236)S8 (270-276)AH10 (286-304)TI9 (232-235)TI11 (237-240)TIV9 (248-251)TI13 (279-282)TI14 (280-283)TI15 (307-310)TII4 (313-316)TIV2 (67-70)AH6 (184-193)TIV10 (283-286)3H1 (24-26)TVIII3 (244-247)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Rattus norvegicus
publication title Design of Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase
pubmed doi rcsb
molecule keywords Arginase 1
total genus 108
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2003-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1r1oA00
1P8OA 1GQ6A 4HWWA 3E6VA 3TF3A 3E6KA 4Q3RA 3RLAA 4RHQA 4IU1A 4G3HA 4Q42A 1T4SA 4Q3RC 3NIOA 1RLAA 3GMZA 4IU0A 4Q3UA 1R1OA 3THHA 4MYNA 1WOIA 1HQFA 1T5GA 1XFKA 2EF5A 1D3VA 4Q3QA 3F80A 3MFWA 3CEVA 4IU5A 4CEVA 3NIPA 1ZPEA 3NIQA 2AEBA 3THEA 1T5FA 3M1RA 1P8SA 4IXVA 4RHLA 2EIVA 1P8NA 3SKKA 4Q3PA 4Q3VA 3PZLA 1P8QA 4RHKA 5HJ9A 1WOHA 1GQ7A 4ITYA 3KV2A 3MMRA 4I06A 2CEVA 4GWDA 4MYLA 1TA1A 4Q40A 3GN0A 1P8PA 1P8RA 1CEVA 4HXQA 1HQ5A 1T4RA 4IXUA 2ZAVA 4Q3SA 2PHAA 1HQHA 4RHIA 3MJLA 1TBJA 1TBHA 4GSMA 4MYKA 4IE3A 4IE2A 4RHJA 3SL0A 4RHMA 4GWCA 3TH7A 1ZPGA 1T4PA 4HZEA 4RLAA 3E8ZA 4DZ4A 5HJAA 3DJ8A 5RLAA 1HQXA 1WVAA 3MFVA 4IU4A 4GSZA 1WOGA 4Q3TA 3LP7A 3SJTA 3LP4A 2EF4A 4MYFA 2PLLA 1WVBA 4MXRA 3THJA 1P8MA 2RLAA 4FCIA 4GSVA 4Q41A 1T4TA 4FCKA 3SL1A 2A0MA 1TBLA 1PQ3A 3E9BA 3E8QA 4IE1A 1HQGA 2PHOA 3LHLA 5CEVA
chains in the Genus database with same CATH superfamily
1P8OA 2VQWG 5FCWA 1GQ6A 4HWWA 3E6VA 3F06A 3TF3A 3E6KA 4Q3RA 3RLAA 4RN0A 4RHQA 4QA1A 4QA0A 4IU1A 4G3HA 4Q42A 3MZ6A 3SFFA 5G1BA 1W22A 1T4SA 4Q3RC 4LXZA 3NIOA 5THVA 1C3PA 1RLAA 5BWZA 2VQMA 3GMZA 4IU0A 1R1OA 4Q3UA 3THHA 4MYNA 5EENA 5THUA 1WOIA 4ZUMA 1HQFA 1T5GA 1XFKA 1ZZ1A 4BZ8A 2EF5A 5EEFA 1D3VA 4RN2A 5G11A 4ZUQA 1T69A 4CBTA 5EEKA 4Q3QA 5ICNB 3F80A 3MFWA 4QA5A 3SFHA 3CEVA 4IU5A 5G0GA 5DC7A 5G10A 3NIPA 4CEVA 3F07A 2V5XA 5EFJD 1ZPEA 5DC6A 3NIQA 2VQVA 2AEBA 5LI3A 3THEA 5IX0A 1T5FA 4BKXB 3M1RA 1P8SA 4CBYA 5G1CA 5G17A 5G0IA 5G0YA 4IXVA 4RHLA 2EIVA 2VQJA 1P8NA 3EZPA 3MAXA 5G3WA 3SKKA 2V5WA 1T64A 4Q3PA 3PZLA 4Q3VA 1P8QA 5G0JA 2VQOA 4LY1A 4RHKA 5EFKB 5HJ9A 4A69A 4BZ9A 1WOHA 3Q9EA 1GQ7A 5D1DA 5G0HA 4ITYA 3KV2A 1C3SA 4QA7A 1VKGA 3MMRA 4I06A 2CEVA 4GWDA 4MYLA 4QA6A 1TA1A 5JI5A 4Q40A 5G0XA 5EFNA 3GN0A 5IWGA 3SJTA 1P8PA 5EF8A 3MZ3A 3RQDA 3C0ZA 1P8RA 1CEVA 4HXQA 1HQ5A 1ZZ0A 1T4RA 3C0YA 3Q9FA 4IXUA 2ZAVA 4Q3SA 5A2SA 2PHAA 1HQHA 4RHIA 3MJLA 5DC8A 4ZUNA 3F0RA 5G12A 1TBJA 1TBHA 4GSMA 5G1AA 4MYKA 4BZ6A 4IE3A 4IE2A 5THTA 3MENA 4RHJA 4RHMA 4GWCA 3SL0A 2VCGA 1ZPGA 1T4PA 4HZEA 3E8ZA 4RLAA 3TH7A 4QA2A 5EEMA 4DZ4A 5HJAA 1T67A 2VQQA 3DJ8A 5EFHA 5RLAA 4CQFA 1HQXA 1WVAA 3MFVA 4IU4A 5D1CA 2GH6A 1ZZ3A 1WOGA 3MZ7A 3MZ4A 3Q9CA 4GSZA 4Q3TA 3LP7A 4QA3A 4QA4A 5DC5A 3LP4A 2EF4A 5EEIA 4MYFA 2PLLA 3EWFA 5G13A 1WVBA 3EZTA 3Q9BA 1P8MA 2RLAA 3C10A 4MXRA 4FCIA 4GSVA 3THJA 4BZ7A 4Q41A 1T4TA 4FCKA 5EF7A 3ZNSA 3SL1A 5CEVA 5EFBD 3ZNRA 5EFGA 5THSA 2A0MA 1TBLA 4RN1A 4BZ5A 1PQ3A 3E9BA 3E8QA 5FUEA 5D1BA 4IE1A 4ZUOA 1HQGA 2PHOA 3LHLA 4ZUPA 3EW8A 4ZURA 1C3RA
chains in the Genus database with same CATH topology
1P8OA 1GQ6A 4HWWA 3E6VA 3TF3A 3E6KA 4Q3RA 3RLAA 4RHQA 4IU1A 4G3HA 4Q42A 1T4SA 4Q3RC 3NIOA 1RLAA 3GMZA 4IU0A 4Q3UA 1R1OA 3THHA 4MYNA 1WOIA 1HQFA 1T5GA 1XFKA 2EF5A 1D3VA 4Q3QA 3F80A 3MFWA 3CEVA 4IU5A 4CEVA 3NIPA 1ZPEA 3NIQA 2AEBA 3THEA 1T5FA 3M1RA 1P8SA 4IXVA 4RHLA 2EIVA 1P8NA 3SKKA 4Q3PA 4Q3VA 3PZLA 1P8QA 4RHKA 5HJ9A 1WOHA 1GQ7A 4ITYA 3KV2A 3MMRA 4I06A 2CEVA 4GWDA 4MYLA 1TA1A 4Q40A 3GN0A 1P8PA 1P8RA 1CEVA 4HXQA 1HQ5A 1T4RA 4IXUA 2ZAVA 4Q3SA 2PHAA 1HQHA 4RHIA 3MJLA 1TBJA 1TBHA 4GSMA 4MYKA 4IE3A 4IE2A 4RHJA 3SL0A 4RHMA 4GWCA 3TH7A 1ZPGA 1T4PA 4HZEA 4RLAA 3E8ZA 4DZ4A 5HJAA 3DJ8A 5RLAA 1HQXA 1WVAA 3MFVA 4IU4A 4GSZA 1WOGA 4Q3TA 3LP7A 3SJTA 3LP4A 2EF4A 4MYFA 2PLLA 1WVBA 4MXRA 3THJA 1P8MA 2RLAA 4FCIA 4GSVA 4Q41A 1T4TA 4FCKA 3SL1A 2A0MA 1TBLA 1PQ3A 3E9BA 3E8QA 4IE1A 1HQGA 2PHOA 3LHLA 5CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8O A;  1GQ6 A;  4HWW A;  3E6V A;  3TF3 A;  3E6K A;  4Q3R A;  3RLA A;  4RHQ A;  4IU1 A;  4G3H A;  4Q42 A;  1T4S A;  4Q3R C;  3NIO A;  1RLA A;  3GMZ A;  4IU0 A;  4Q3U A;  1R1O A;  3THH A;  4MYN A;  1WOI A;  1HQF A;  1T5G A;  1XFK A;  2EF5 A;  1D3V A;  4Q3Q A;  3F80 A;  3MFW A;  3CEV A;  4IU5 A;  4CEV A;  3NIP A;  1ZPE A;  3NIQ A;  2AEB A;  3THE A;  1T5F A;  3M1R A;  1P8S A;  4IXV A;  4RHL A;  2EIV A;  1P8N A;  3SKK A;  4Q3P A;  4Q3V A;  3PZL A;  1P8Q A;  4RHK A;  5HJ9 A;  1WOH A;  1GQ7 A;  4ITY A;  3KV2 A;  3MMR A;  4I06 A;  2CEV A;  4GWD A;  4MYL A;  1TA1 A;  4Q40 A;  3GN0 A;  1P8P A;  1P8R A;  1CEV A;  4HXQ A;  1HQ5 A;  1T4R A;  4IXU A;  2ZAV A;  4Q3S A;  2PHA A;  1HQH A;  4RHI A;  3MJL A;  1TBJ A;  1TBH A;  4GSM A;  4MYK A;  4IE3 A;  4IE2 A;  4RHJ A;  3SL0 A;  4RHM A;  4GWC A;  3TH7 A;  1ZPG A;  1T4P A;  4HZE A;  4RLA A;  3E8Z A;  4DZ4 A;  5HJA A;  3DJ8 A;  5RLA A;  1HQX A;  1WVA A;  3MFV A;  4IU4 A;  4GSZ A;  1WOG A;  4Q3T A;  3LP7 A;  3SJT A;  3LP4 A;  2EF4 A;  4MYF A;  2PLL A;  1WVB A;  4MXR A;  3THJ A;  1P8M A;  2RLA A;  4FCI A;  4GSV A;  4Q41 A;  1T4T A;  4FCK A;  3SL1 A;  2A0M A;  1TBL A;  1PQ3 A;  3E9B A;  3E8Q A;  4IE1 A;  1HQG A;  2PHO A;  3LHL A;  5CEV A; 
#chains in the Genus database with same CATH topology
 1P8O A;  2VQW G;  5FCW A;  1GQ6 A;  4HWW A;  3E6V A;  3F06 A;  3TF3 A;  3E6K A;  4Q3R A;  3RLA A;  4RN0 A;  4RHQ A;  4QA1 A;  4QA0 A;  4IU1 A;  4G3H A;  4Q42 A;  3MZ6 A;  3SFF A;  5G1B A;  1W22 A;  1T4S A;  4Q3R C;  4LXZ A;  3NIO A;  5THV A;  1C3P A;  1RLA A;  5BWZ A;  2VQM A;  3GMZ A;  4IU0 A;  1R1O A;  4Q3U A;  3THH A;  4MYN A;  5EEN A;  5THU A;  1WOI A;  4ZUM A;  1HQF A;  1T5G A;  1XFK A;  1ZZ1 A;  4BZ8 A;  2EF5 A;  5EEF A;  1D3V A;  4RN2 A;  5G11 A;  4ZUQ A;  1T69 A;  4CBT A;  5EEK A;  4Q3Q A;  5ICN B;  3F80 A;  3MFW A;  4QA5 A;  3SFH A;  3CEV A;  4IU5 A;  5G0G A;  5DC7 A;  5G10 A;  3NIP A;  4CEV A;  3F07 A;  2V5X A;  5EFJ D;  1ZPE A;  5DC6 A;  3NIQ A;  2VQV A;  2AEB A;  5LI3 A;  3THE A;  5IX0 A;  1T5F A;  4BKX B;  3M1R A;  1P8S A;  4CBY A;  5G1C A;  5G17 A;  5G0I A;  5G0Y A;  4IXV A;  4RHL A;  2EIV A;  2VQJ A;  1P8N A;  3EZP A;  3MAX A;  5G3W A;  3SKK A;  2V5W A;  1T64 A;  4Q3P A;  3PZL A;  4Q3V A;  1P8Q A;  5G0J A;  2VQO A;  4LY1 A;  4RHK A;  5EFK B;  5HJ9 A;  4A69 A;  4BZ9 A;  1WOH A;  3Q9E A;  1GQ7 A;  5D1D A;  5G0H A;  4ITY A;  3KV2 A;  1C3S A;  4QA7 A;  1VKG A;  3MMR A;  4I06 A;  2CEV A;  4GWD A;  4MYL A;  4QA6 A;  1TA1 A;  5JI5 A;  4Q40 A;  5G0X A;  5EFN A;  3GN0 A;  5IWG A;  3SJT A;  1P8P A;  5EF8 A;  3MZ3 A;  3RQD A;  3C0Z A;  1P8R A;  1CEV A;  4HXQ A;  1HQ5 A;  1ZZ0 A;  1T4R A;  3C0Y A;  3Q9F A;  4IXU A;  2ZAV A;  4Q3S A;  5A2S A;  2PHA A;  1HQH A;  4RHI A;  3MJL A;  5DC8 A;  4ZUN A;  3F0R A;  5G12 A;  1TBJ A;  1TBH A;  4GSM A;  5G1A A;  4MYK A;  4BZ6 A;  4IE3 A;  4IE2 A;  5THT A;  3MEN A;  4RHJ A;  4RHM A;  4GWC A;  3SL0 A;  2VCG A;  1ZPG A;  1T4P A;  4HZE A;  3E8Z A;  4RLA A;  3TH7 A;  4QA2 A;  5EEM A;  4DZ4 A;  5HJA A;  1T67 A;  2VQQ A;  3DJ8 A;  5EFH A;  5RLA A;  4CQF A;  1HQX A;  1WVA A;  3MFV A;  4IU4 A;  5D1C A;  2GH6 A;  1ZZ3 A;  1WOG A;  3MZ7 A;  3MZ4 A;  3Q9C A;  4GSZ A;  4Q3T A;  3LP7 A;  4QA3 A;  4QA4 A;  5DC5 A;  3LP4 A;  2EF4 A;  5EEI A;  4MYF A;  2PLL A;  3EWF A;  5G13 A;  1WVB A;  3EZT A;  3Q9B A;  1P8M A;  2RLA A;  3C10 A;  4MXR A;  4FCI A;  4GSV A;  3THJ A;  4BZ7 A;  4Q41 A;  1T4T A;  4FCK A;  5EF7 A;  3ZNS A;  3SL1 A;  5CEV A;  5EFB D;  3ZNR A;  5EFG A;  5THS A;  2A0M A;  1TBL A;  4RN1 A;  4BZ5 A;  1PQ3 A;  3E9B A;  3E8Q A;  5FUE A;  5D1B A;  4IE1 A;  4ZUO A;  1HQG A;  2PHO A;  3LHL A;  4ZUP A;  3EW8 A;  4ZUR A;  1C3R A; 
#chains in the Genus database with same CATH homology
 1P8O A;  1GQ6 A;  4HWW A;  3E6V A;  3TF3 A;  3E6K A;  4Q3R A;  3RLA A;  4RHQ A;  4IU1 A;  4G3H A;  4Q42 A;  1T4S A;  4Q3R C;  3NIO A;  1RLA A;  3GMZ A;  4IU0 A;  4Q3U A;  1R1O A;  3THH A;  4MYN A;  1WOI A;  1HQF A;  1T5G A;  1XFK A;  2EF5 A;  1D3V A;  4Q3Q A;  3F80 A;  3MFW A;  3CEV A;  4IU5 A;  4CEV A;  3NIP A;  1ZPE A;  3NIQ A;  2AEB A;  3THE A;  1T5F A;  3M1R A;  1P8S A;  4IXV A;  4RHL A;  2EIV A;  1P8N A;  3SKK A;  4Q3P A;  4Q3V A;  3PZL A;  1P8Q A;  4RHK A;  5HJ9 A;  1WOH A;  1GQ7 A;  4ITY A;  3KV2 A;  3MMR A;  4I06 A;  2CEV A;  4GWD A;  4MYL A;  1TA1 A;  4Q40 A;  3GN0 A;  1P8P A;  1P8R A;  1CEV A;  4HXQ A;  1HQ5 A;  1T4R A;  4IXU A;  2ZAV A;  4Q3S A;  2PHA A;  1HQH A;  4RHI A;  3MJL A;  1TBJ A;  1TBH A;  4GSM A;  4MYK A;  4IE3 A;  4IE2 A;  4RHJ A;  3SL0 A;  4RHM A;  4GWC A;  3TH7 A;  1ZPG A;  1T4P A;  4HZE A;  4RLA A;  3E8Z A;  4DZ4 A;  5HJA A;  3DJ8 A;  5RLA A;  1HQX A;  1WVA A;  3MFV A;  4IU4 A;  4GSZ A;  1WOG A;  4Q3T A;  3LP7 A;  3SJT A;  3LP4 A;  2EF4 A;  4MYF A;  2PLL A;  1WVB A;  4MXR A;  3THJ A;  1P8M A;  2RLA A;  4FCI A;  4GSV A;  4Q41 A;  1T4T A;  4FCK A;  3SL1 A;  2A0M A;  1TBL A;  1PQ3 A;  3E9B A;  3E8Q A;  4IE1 A;  1HQG A;  2PHO A;  3LHL A;  5CEV A; 
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