1T64 | Genus

Total Genus 131

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	131
sequence length	364
structure length	364
Chain Sequence	LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases pubmed doi rcsb
molecule keywords	Histone deacetylase 8
total genus	131
structure length	364
sequence length	364
chains with identical sequence	B
ec nomenclature	ec 3.5.1.98: Histone deacetylase.
pdb deposition date	2004-05-05

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00850	Hist_deacetyl	Histone deacetylase domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.800.20	Alpha Beta	3-Layer(aba) Sandwich	Arginase; Chain A	Histone deacetylase domain	1t64A00

5EFNA 3EW8A 5G10A 1ZZ0A 3ZNSA 5D1DA 5G17A 3EZTA 1ZZ1A 3MZ6A 5IWGA 1ZZ3A 3MAXA 2VCGA 3Q9EA 3C10A 4QA3A 5EEKA 2GH6A 3EZPA 3SFHA 5G0YA 5EENA 4RN1A 2V5XA 3EWFA 4QA6A 4QA7A 5G1BA 5FCWA 5EF8A 5EEIA 5DC6A 3C0YA 4A69A 3F0RA 4BZ5A 4QA4A 5G0HA 4BZ8A 5G13A 1T64A 1VKGA 4LY1A 4ZUNA 2V5WA 5G0GA 5DC5A 5EFGA 3RQDA 4BZ6A 4RN0A 2VQJA 3ZNRA 4ZUQA 4ZUMA 2VQMA 5DC8A 4ZUPA 1C3PA 4QA5A 5FUEA 5G11A 5G3WA 4CBYA 2VQQA 3Q9CA 5ICNB 5G1AA 3Q9FA 3Q9BA 5EEFA 5G0IA 5THTA 4BZ7A 3F06A 5EF7A 2VQOA 4ZUOA 5D1CA 2VQVA 3MENA 4BKXB 4ZURA 5THVA 5A2SA 5G0XA 3C0ZA 5EFKB 4RN2A 5D1BA 3MZ7A 4LXZA 4CQFA 1T67A 5EFJD 5EFHA 5THSA 5BWZA 2VQWG 3MZ3A 5G12A 3SFFA 1T69A 5JI5A 1C3SA 5EEMA 1C3RA 5G1CA 5IX0A 4BZ9A 5LI3A 5DC7A 5THUA 4CBTA 4QA0A 1W22A 3MZ4A 4QA1A 5G0JA 3F07A 5EFBD 4QA2A
chains in the Genus database with same CATH superfamily

5EFNA 3EW8A 5G10A 1ZZ0A 3ZNSA 1RLAA 4CEVA 2EIVA 5D1DA 5G17A 3EZTA 1ZZ1A 4RHJA 3MZ6A 1CEVA 4HZEA 3THEA 4Q3SA 5IWGA 3F80A 1ZZ3A 3NIQA 1HQFA 1HQ5A 3MAXA 2EF4A 2VCGA 4Q3TA 3MJLA 4RHKA 3Q9EA 3C10A 4QA3A 3SJTA 3MFWA 5EEKA 4ITYA 2GH6A 3EZPA 4Q3RC 1P8PA 3LHLA 3SFHA 5G0YA 1R1OA 4RLAA 5EENA 1WOGA 4RN1A 2V5XA 3EWFA 1PQ3A 4QA6A 4QA7A 5G1BA 5FCWA 3E8QA 5EEIA 5DC6A 3C0YA 5EF8A 3F0RA 4A69A 4GSMA 4BZ5A 5HJAA 1HQXA 4QA4A 5G0HA 4BZ8A 4HWWA 5G13A 1T64A 1VKGA 3E6VA 3MFVA 1XFKA 4GWCA 1T4PA 2V5WA 4LY1A 1TA1A 4ZUNA 5G0GA 4FCIA 5DC5A 5EFGA 3RQDA 4BZ6A 4IU1A 1P8QA 4MYFA 4RN0A 2VQJA 4MXRA 3ZNRA 4ZUQA 3TF3A 3M1RA 4ZUMA 1GQ7A 2VQMA 5DC8A 4ZUPA 3GMZA 4GSVA 2RLAA 1C3PA 4QA5A 5FUEA 1P8OA 5G11A 1T4TA 5G3WA 3PZLA 4CBYA 2PHAA 2VQQA 3Q9CA 4Q40A 3DJ8A 5ICNB 5G1AA 1TBHA 4G3HA 3Q9FA 4IXVA 1D3VA 3Q9BA 5EEFA 5G0IA 5THTA 4IE2A 3NIOA 1HQGA 4RHIA 4BZ7A 3E9BA 3F06A 5EF7A 2VQOA 4GSZA 2EF5A 3E8ZA 4MYLA 4Q3VA 4Q3UA 4RHQA 1TBLA 4IE3A 3KV2A 3CEVA 4ZUOA 4Q41A 5D1CA 2VQVA 3MENA 4IU5A 4BKXB 1WVBA 4ZURA 2A0MA 1GQ6A 5THVA 5A2SA 4MYKA 1T5GA 2PHOA 5G0XA 3C0ZA 5RLAA 4FCKA 5EFKB 4DZ4A 2PLLA 4RN2A 5D1BA 4GWDA 3MZ7A 4Q3PA 4LXZA 1WVAA 4Q3QA 4CQFA 3NIPA 4IU4A 1WOHA 1T67A 2CEVA 1TBJA 5EFJD 5EFHA 5THSA 4I06A 5BWZA 4IU0A 4RHLA 3THHA 2VQWG 3MZ3A 3SKKA 1T4SA 5G12A 3SFFA 3TH7A 1T69A 4RHMA 1P8RA 1ZPGA 1HQHA 5JI5A 1C3SA 4Q3RA 5EEMA 1ZPEA 3THJA 3SL0A 1C3RA 1WOIA 3MMRA 5G1CA 3SL1A 5IX0A 2ZAVA 4Q42A 4BZ9A 5LI3A 4HXQA 1P8NA 4IXUA 1T4RA 5DC7A 5THUA 3RLAA 4MYNA 4CBTA 3E6KA 4QA0A 5CEVA 1W22A 3MZ4A 4QA1A 3LP7A 3LP4A 5G0JA 5HJ9A 1P8SA 3F07A 1P8MA 3GN0A 5EFBD 2AEBA 4IE1A 4QA2A 1T5FA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 5EFN A;  3EW8 A;  5G10 A;  1ZZ0 A;  3ZNS A;  5D1D A;  5G17 A;  3EZT A;  1ZZ1 A;  3MZ6 A;  5IWG A;  1ZZ3 A;  3MAX A;  2VCG A;  3Q9E A;  3C10 A;  4QA3 A;  5EEK A;  2GH6 A;  3EZP A;  3SFH A;  5G0Y A;  5EEN A;  4RN1 A;  2V5X A;  3EWF A;  4QA6 A;  4QA7 A;  5G1B A;  5FCW A;  5EF8 A;  5EEI A;  5DC6 A;  3C0Y A;  4A69 A;  3F0R A;  4BZ5 A;  4QA4 A;  5G0H A;  4BZ8 A;  5G13 A;  1T64 A;  1VKG A;  4LY1 A;  4ZUN A;  2V5W A;  5G0G A;  5DC5 A;  5EFG A;  3RQD A;  4BZ6 A;  4RN0 A;  2VQJ A;  3ZNR A;  4ZUQ A;  4ZUM A;  2VQM A;  5DC8 A;  4ZUP A;  1C3P A;  4QA5 A;  5FUE A;  5G11 A;  5G3W A;  4CBY A;  2VQQ A;  3Q9C A;  5ICN B;  5G1A A;  3Q9F A;  3Q9B A;  5EEF A;  5G0I A;  5THT A;  4BZ7 A;  3F06 A;  5EF7 A;  2VQO A;  4ZUO A;  5D1C A;  2VQV A;  3MEN A;  4BKX B;  4ZUR A;  5THV A;  5A2S A;  5G0X A;  3C0Z A;  5EFK B;  4RN2 A;  5D1B A;  3MZ7 A;  4LXZ A;  4CQF A;  1T67 A;  5EFJ D;  5EFH A;  5THS A;  5BWZ A;  2VQW G;  3MZ3 A;  5G12 A;  3SFF A;  1T69 A;  5JI5 A;  1C3S A;  5EEM A;  1C3R A;  5G1C A;  5IX0 A;  4BZ9 A;  5LI3 A;  5DC7 A;  5THU A;  4CBT A;  4QA0 A;  1W22 A;  3MZ4 A;  4QA1 A;  5G0J A;  3F07 A;  5EFB D;  4QA2 A; 
#chains in the Genus database with same CATH topology
 5EFN A;  3EW8 A;  5G10 A;  1ZZ0 A;  3ZNS A;  1RLA A;  4CEV A;  2EIV A;  5D1D A;  5G17 A;  3EZT A;  1ZZ1 A;  4RHJ A;  3MZ6 A;  1CEV A;  4HZE A;  3THE A;  4Q3S A;  5IWG A;  3F80 A;  1ZZ3 A;  3NIQ A;  1HQF A;  1HQ5 A;  3MAX A;  2EF4 A;  2VCG A;  4Q3T A;  3MJL A;  4RHK A;  3Q9E A;  3C10 A;  4QA3 A;  3SJT A;  3MFW A;  5EEK A;  4ITY A;  2GH6 A;  3EZP A;  4Q3R C;  1P8P A;  3LHL A;  3SFH A;  5G0Y A;  1R1O A;  4RLA A;  5EEN A;  1WOG A;  4RN1 A;  2V5X A;  3EWF A;  1PQ3 A;  4QA6 A;  4QA7 A;  5G1B A;  5FCW A;  3E8Q A;  5EEI A;  5DC6 A;  3C0Y A;  5EF8 A;  3F0R A;  4A69 A;  4GSM A;  4BZ5 A;  5HJA A;  1HQX A;  4QA4 A;  5G0H A;  4BZ8 A;  4HWW A;  5G13 A;  1T64 A;  1VKG A;  3E6V A;  3MFV A;  1XFK A;  4GWC A;  1T4P A;  2V5W A;  4LY1 A;  1TA1 A;  4ZUN A;  5G0G A;  4FCI A;  5DC5 A;  5EFG A;  3RQD A;  4BZ6 A;  4IU1 A;  1P8Q A;  4MYF A;  4RN0 A;  2VQJ A;  4MXR A;  3ZNR A;  4ZUQ A;  3TF3 A;  3M1R A;  4ZUM A;  1GQ7 A;  2VQM A;  5DC8 A;  4ZUP A;  3GMZ A;  4GSV A;  2RLA A;  1C3P A;  4QA5 A;  5FUE A;  1P8O A;  5G11 A;  1T4T A;  5G3W A;  3PZL A;  4CBY A;  2PHA A;  2VQQ A;  3Q9C A;  4Q40 A;  3DJ8 A;  5ICN B;  5G1A A;  1TBH A;  4G3H A;  3Q9F A;  4IXV A;  1D3V A;  3Q9B A;  5EEF A;  5G0I A;  5THT A;  4IE2 A;  3NIO A;  1HQG A;  4RHI A;  4BZ7 A;  3E9B A;  3F06 A;  5EF7 A;  2VQO A;  4GSZ A;  2EF5 A;  3E8Z A;  4MYL A;  4Q3V A;  4Q3U A;  4RHQ A;  1TBL A;  4IE3 A;  3KV2 A;  3CEV A;  4ZUO A;  4Q41 A;  5D1C A;  2VQV A;  3MEN A;  4IU5 A;  4BKX B;  1WVB A;  4ZUR A;  2A0M A;  1GQ6 A;  5THV A;  5A2S A;  4MYK A;  1T5G A;  2PHO A;  5G0X A;  3C0Z A;  5RLA A;  4FCK A;  5EFK B;  4DZ4 A;  2PLL A;  4RN2 A;  5D1B A;  4GWD A;  3MZ7 A;  4Q3P A;  4LXZ A;  1WVA A;  4Q3Q A;  4CQF A;  3NIP A;  4IU4 A;  1WOH A;  1T67 A;  2CEV A;  1TBJ A;  5EFJ D;  5EFH A;  5THS A;  4I06 A;  5BWZ A;  4IU0 A;  4RHL A;  3THH A;  2VQW G;  3MZ3 A;  3SKK A;  1T4S A;  5G12 A;  3SFF A;  3TH7 A;  1T69 A;  4RHM A;  1P8R A;  1ZPG A;  1HQH A;  5JI5 A;  1C3S A;  4Q3R A;  5EEM A;  1ZPE A;  3THJ A;  3SL0 A;  1C3R A;  1WOI A;  3MMR A;  5G1C A;  3SL1 A;  5IX0 A;  2ZAV A;  4Q42 A;  4BZ9 A;  5LI3 A;  4HXQ A;  1P8N A;  4IXU A;  1T4R A;  5DC7 A;  5THU A;  3RLA A;  4MYN A;  4CBT A;  3E6K A;  4QA0 A;  5CEV A;  1W22 A;  3MZ4 A;  4QA1 A;  3LP7 A;  3LP4 A;  5G0J A;  5HJ9 A;  1P8S A;  3F07 A;  1P8M A;  3GN0 A;  5EFB D;  2AEB A;  4IE1 A;  4QA2 A;  1T5F A; 
#chains in the Genus database with same CATH homology
 5EFN A;  3EW8 A;  5G10 A;  1ZZ0 A;  3ZNS A;  5D1D A;  5G17 A;  3EZT A;  1ZZ1 A;  3MZ6 A;  5IWG A;  1ZZ3 A;  3MAX A;  2VCG A;  3Q9E A;  3C10 A;  4QA3 A;  5EEK A;  2GH6 A;  3EZP A;  3SFH A;  5G0Y A;  5EEN A;  4RN1 A;  2V5X A;  3EWF A;  4QA6 A;  4QA7 A;  5G1B A;  5FCW A;  5EF8 A;  5EEI A;  5DC6 A;  3C0Y A;  4A69 A;  3F0R A;  4BZ5 A;  4QA4 A;  5G0H A;  4BZ8 A;  5G13 A;  1T64 A;  1VKG A;  4LY1 A;  4ZUN A;  2V5W A;  5G0G A;  5DC5 A;  5EFG A;  3RQD A;  4BZ6 A;  4RN0 A;  2VQJ A;  3ZNR A;  4ZUQ A;  4ZUM A;  2VQM A;  5DC8 A;  4ZUP A;  1C3P A;  4QA5 A;  5FUE A;  5G11 A;  5G3W A;  4CBY A;  2VQQ A;  3Q9C A;  5ICN B;  5G1A A;  3Q9F A;  3Q9B A;  5EEF A;  5G0I A;  5THT A;  4BZ7 A;  3F06 A;  5EF7 A;  2VQO A;  4ZUO A;  5D1C A;  2VQV A;  3MEN A;  4BKX B;  4ZUR A;  5THV A;  5A2S A;  5G0X A;  3C0Z A;  5EFK B;  4RN2 A;  5D1B A;  3MZ7 A;  4LXZ A;  4CQF A;  1T67 A;  5EFJ D;  5EFH A;  5THS A;  5BWZ A;  2VQW G;  3MZ3 A;  5G12 A;  3SFF A;  1T69 A;  5JI5 A;  1C3S A;  5EEM A;  1C3R A;  5G1C A;  5IX0 A;  4BZ9 A;  5LI3 A;  5DC7 A;  5THU A;  4CBT A;  4QA0 A;  1W22 A;  3MZ4 A;  4QA1 A;  5G0J A;  3F07 A;  5EFB D;  4QA2 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1T64A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations