1WVAA

Crystal structure of human arginase i from twinned crystal
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
309
structure length
309
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Arginase 1
total genus 109
structure length 309
sequence length 309
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2004-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1wvaA00
4RHMA 1HQXA 1T4TA 4GSMA 1WVAA 4RHJA 2PHAA 3TH7A 2RLAA 3RLAA 1WOGA 3LHLA 3THJA 2A0MA 3PZLA 1D3VA 4IE3A 4Q42A 3THEA 4IE1A 3KV2A 3THHA 4Q3QA 1T5FA 1T4RA 4RHIA 4IU5A 1HQ5A 4HXQA 3MFVA 4RHLA 1T4PA 4ITYA 4Q40A 1HQGA 5CEVA 4MYKA 3M1RA 4MXRA 1TBHA 3NIQA 4IXUA 4IU0A 1HQHA 4RLAA 4IU4A 1TA1A 3LP7A 1TBJA 4CEVA 1P8PA 4GSZA 4FCIA 2AEBA 2CEVA 1GQ7A 1WOIA 1WOHA 3E6VA 3TF3A 4Q3PA 2ZAVA 3MFWA 4Q3SA 1WVBA 3NIOA 4RHQA 1P8QA 4Q3VA 3GMZA 4DZ4A 3F80A 4IXVA 3SL0A 4Q3TA 4G3HA 1P8OA 1XFKA 2EF5A 4HWWA 1P8NA 2EF4A 4GWDA 2EIVA 4IE2A 4HZEA 1HQFA 4MYLA 3CEVA 1CEVA 4IU1A 1ZPGA 1T5GA 4Q3RC 4I06A 3NIPA 1GQ6A 4FCKA 2PHOA 5HJ9A 4Q3RA 3MMRA 1RLAA 3MJLA 3DJ8A 3SKKA 1P8RA 4MYFA 1T4SA 1ZPEA 4RHKA 1P8SA 3E9BA 4Q41A 4MYNA 4Q3UA 5HJAA 1TBLA 1P8MA 3SJTA 3E6KA 3E8ZA 1R1OA 3GN0A 3E8QA 3SL1A 2PLLA 4GSVA 1PQ3A 5RLAA 4GWCA 3LP4A
chains in the Genus database with same CATH superfamily
4RHMA 5G17A 1HQXA 1T4TA 4GSMA 3Q9FA 1WVAA 3F0RA 2PHAA 1C3RA 3Q9CA 4RHJA 2RLAA 2VQMA 5EFNA 3RLAA 3TH7A 1WOGA 3C0YA 3LHLA 5G11A 5EF8A 5THUA 3THJA 5JI5A 2A0MA 3PZLA 1D3VA 1C3PA 4IE3A 1ZZ0A 4IE1A 3KV2A 4Q42A 4Q3QA 4ZUNA 3THEA 3ZNSA 4BZ5A 3RQDA 1T5FA 5D1DA 1T4RA 5ICNB 3C0ZA 4RHIA 4IU5A 4ZUPA 1HQ5A 3MZ7A 4HXQA 5DC8A 5G3WA 3MFVA 4RHLA 5G10A 1T4PA 3MAXA 4ITYA 5G0HA 5G13A 2VQVA 2VQJA 1VKGA 3F07A 5BWZA 4Q40A 1HQGA 5CEVA 4MYKA 3M1RA 4MXRA 5G12A 1TBHA 3NIQA 4QA0A 4IXUA 1W22A 3EW8A 4IU0A 5D1CA 4BZ8A 4BZ6A 1HQHA 2VQQA 1ZZ1A 4RLAA 4ZUQA 5EEIA 5G0IA 2V5WA 1TA1A 4IU4A 1T69A 3LP7A 1TBJA 4CEVA 1P8PA 4GSZA 5EEFA 4FCIA 2AEBA 2CEVA 1GQ7A 1WOIA 4ZURA 3Q9BA 1ZZ3A 4CBYA 1WOHA 3E6VA 4BZ9A 5EFGA 5G1AA 3TF3A 3C10A 4QA5A 4LXZA 4Q3PA 5G0GA 2ZAVA 4LY1A 3MFWA 4Q3SA 5IX0A 1WVBA 3NIOA 4RHQA 4RN2A 4RN1A 3MZ6A 5G1BA 1P8QA 4Q3VA 3GMZA 4DZ4A 3F80A 3MENA 4BZ7A 5EFJD 4IXVA 5G1CA 3SL0A 5EEKA 4Q3TA 4RN0A 4G3HA 1P8OA 1XFKA 2EF5A 4QA2A 4HWWA 5D1BA 5FCWA 3THHA 1P8NA 2EF4A 3MZ4A 4GWDA 5EEMA 2EIVA 3F06A 4IE2A 5EENA 5THTA 5A2SA 5EF7A 4HZEA 1HQFA 3LP4A 3MZ3A 4MYLA 3CEVA 1CEVA 4IU1A 1ZPGA 1T5GA 5THSA 5EFHA 4Q3RC 4I06A 3EZTA 2VCGA 4ZUMA 3NIPA 1GQ6A 4FCKA 2PHOA 4BKXB 4QA4A 5DC5A 5LI3A 5HJ9A 3Q9EA 4ZUOA 4Q3RA 3MMRA 1RLAA 3MJLA 3DJ8A 3SKKA 5G0YA 3EZPA 4QA7A 4CQFA 1P8RA 4A69A 4MYFA 5THVA 4QA6A 1T4SA 3SFHA 2VQOA 5G0JA 5DC6A 5DC7A 1ZPEA 4RHKA 1P8SA 3E9BA 3SFFA 4MYNA 4Q3UA 4CBTA 1TBLA 5FUEA 4Q41A 5IWGA 2GH6A 5EFKB 1P8MA 3ZNRA 3SJTA 3E6KA 4QA1A 3E8ZA 1C3SA 1R1OA 3GN0A 3E8QA 5G0XA 3SL1A 1T67A 2PLLA 3EWFA 4GSVA 5EFBD 2V5XA 1PQ3A 5RLAA 2VQWG 4QA3A 4GWCA 5HJAA 1T64A
chains in the Genus database with same CATH topology
4RHMA 1HQXA 1T4TA 4GSMA 1WVAA 4RHJA 2PHAA 3TH7A 2RLAA 3RLAA 1WOGA 3LHLA 3THJA 2A0MA 3PZLA 1D3VA 4IE3A 4Q42A 3THEA 4IE1A 3KV2A 3THHA 4Q3QA 1T5FA 1T4RA 4RHIA 4IU5A 1HQ5A 4HXQA 3MFVA 4RHLA 1T4PA 4ITYA 4Q40A 1HQGA 5CEVA 4MYKA 3M1RA 4MXRA 1TBHA 3NIQA 4IXUA 4IU0A 1HQHA 4RLAA 4IU4A 1TA1A 3LP7A 1TBJA 4CEVA 1P8PA 4GSZA 4FCIA 2AEBA 2CEVA 1GQ7A 1WOIA 1WOHA 3E6VA 3TF3A 4Q3PA 2ZAVA 3MFWA 4Q3SA 1WVBA 3NIOA 4RHQA 1P8QA 4Q3VA 3GMZA 4DZ4A 3F80A 4IXVA 3SL0A 4Q3TA 4G3HA 1P8OA 1XFKA 2EF5A 4HWWA 1P8NA 2EF4A 4GWDA 2EIVA 4IE2A 4HZEA 1HQFA 4MYLA 3CEVA 1CEVA 4IU1A 1ZPGA 1T5GA 4Q3RC 4I06A 3NIPA 1GQ6A 4FCKA 2PHOA 5HJ9A 4Q3RA 3MMRA 1RLAA 3MJLA 3DJ8A 3SKKA 1P8RA 4MYFA 1T4SA 1ZPEA 4RHKA 1P8SA 3E9BA 4Q41A 4MYNA 4Q3UA 5HJAA 1TBLA 1P8MA 3SJTA 3E6KA 3E8ZA 1R1OA 3GN0A 3E8QA 3SL1A 2PLLA 4GSVA 1PQ3A 5RLAA 4GWCA 3LP4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RHM A;  1HQX A;  1T4T A;  4GSM A;  1WVA A;  4RHJ A;  2PHA A;  3TH7 A;  2RLA A;  3RLA A;  1WOG A;  3LHL A;  3THJ A;  2A0M A;  3PZL A;  1D3V A;  4IE3 A;  4Q42 A;  3THE A;  4IE1 A;  3KV2 A;  3THH A;  4Q3Q A;  1T5F A;  1T4R A;  4RHI A;  4IU5 A;  1HQ5 A;  4HXQ A;  3MFV A;  4RHL A;  1T4P A;  4ITY A;  4Q40 A;  1HQG A;  5CEV A;  4MYK A;  3M1R A;  4MXR A;  1TBH A;  3NIQ A;  4IXU A;  4IU0 A;  1HQH A;  4RLA A;  4IU4 A;  1TA1 A;  3LP7 A;  1TBJ A;  4CEV A;  1P8P A;  4GSZ A;  4FCI A;  2AEB A;  2CEV A;  1GQ7 A;  1WOI A;  1WOH A;  3E6V A;  3TF3 A;  4Q3P A;  2ZAV A;  3MFW A;  4Q3S A;  1WVB A;  3NIO A;  4RHQ A;  1P8Q A;  4Q3V A;  3GMZ A;  4DZ4 A;  3F80 A;  4IXV A;  3SL0 A;  4Q3T A;  4G3H A;  1P8O A;  1XFK A;  2EF5 A;  4HWW A;  1P8N A;  2EF4 A;  4GWD A;  2EIV A;  4IE2 A;  4HZE A;  1HQF A;  4MYL A;  3CEV A;  1CEV A;  4IU1 A;  1ZPG A;  1T5G A;  4Q3R C;  4I06 A;  3NIP A;  1GQ6 A;  4FCK A;  2PHO A;  5HJ9 A;  4Q3R A;  3MMR A;  1RLA A;  3MJL A;  3DJ8 A;  3SKK A;  1P8R A;  4MYF A;  1T4S A;  1ZPE A;  4RHK A;  1P8S A;  3E9B A;  4Q41 A;  4MYN A;  4Q3U A;  5HJA A;  1TBL A;  1P8M A;  3SJT A;  3E6K A;  3E8Z A;  1R1O A;  3GN0 A;  3E8Q A;  3SL1 A;  2PLL A;  4GSV A;  1PQ3 A;  5RLA A;  4GWC A;  3LP4 A; 
#chains in the Genus database with same CATH topology
 4RHM A;  5G17 A;  1HQX A;  1T4T A;  4GSM A;  3Q9F A;  1WVA A;  3F0R A;  2PHA A;  1C3R A;  3Q9C A;  4RHJ A;  2RLA A;  2VQM A;  5EFN A;  3RLA A;  3TH7 A;  1WOG A;  3C0Y A;  3LHL A;  5G11 A;  5EF8 A;  5THU A;  3THJ A;  5JI5 A;  2A0M A;  3PZL A;  1D3V A;  1C3P A;  4IE3 A;  1ZZ0 A;  4IE1 A;  3KV2 A;  4Q42 A;  4Q3Q A;  4ZUN A;  3THE A;  3ZNS A;  4BZ5 A;  3RQD A;  1T5F A;  5D1D A;  1T4R A;  5ICN B;  3C0Z A;  4RHI A;  4IU5 A;  4ZUP A;  1HQ5 A;  3MZ7 A;  4HXQ A;  5DC8 A;  5G3W A;  3MFV A;  4RHL A;  5G10 A;  1T4P A;  3MAX A;  4ITY A;  5G0H A;  5G13 A;  2VQV A;  2VQJ A;  1VKG A;  3F07 A;  5BWZ A;  4Q40 A;  1HQG A;  5CEV A;  4MYK A;  3M1R A;  4MXR A;  5G12 A;  1TBH A;  3NIQ A;  4QA0 A;  4IXU A;  1W22 A;  3EW8 A;  4IU0 A;  5D1C A;  4BZ8 A;  4BZ6 A;  1HQH A;  2VQQ A;  1ZZ1 A;  4RLA A;  4ZUQ A;  5EEI A;  5G0I A;  2V5W A;  1TA1 A;  4IU4 A;  1T69 A;  3LP7 A;  1TBJ A;  4CEV A;  1P8P A;  4GSZ A;  5EEF A;  4FCI A;  2AEB A;  2CEV A;  1GQ7 A;  1WOI A;  4ZUR A;  3Q9B A;  1ZZ3 A;  4CBY A;  1WOH A;  3E6V A;  4BZ9 A;  5EFG A;  5G1A A;  3TF3 A;  3C10 A;  4QA5 A;  4LXZ A;  4Q3P A;  5G0G A;  2ZAV A;  4LY1 A;  3MFW A;  4Q3S A;  5IX0 A;  1WVB A;  3NIO A;  4RHQ A;  4RN2 A;  4RN1 A;  3MZ6 A;  5G1B A;  1P8Q A;  4Q3V A;  3GMZ A;  4DZ4 A;  3F80 A;  3MEN A;  4BZ7 A;  5EFJ D;  4IXV A;  5G1C A;  3SL0 A;  5EEK A;  4Q3T A;  4RN0 A;  4G3H A;  1P8O A;  1XFK A;  2EF5 A;  4QA2 A;  4HWW A;  5D1B A;  5FCW A;  3THH A;  1P8N A;  2EF4 A;  3MZ4 A;  4GWD A;  5EEM A;  2EIV A;  3F06 A;  4IE2 A;  5EEN A;  5THT A;  5A2S A;  5EF7 A;  4HZE A;  1HQF A;  3LP4 A;  3MZ3 A;  4MYL A;  3CEV A;  1CEV A;  4IU1 A;  1ZPG A;  1T5G A;  5THS A;  5EFH A;  4Q3R C;  4I06 A;  3EZT A;  2VCG A;  4ZUM A;  3NIP A;  1GQ6 A;  4FCK A;  2PHO A;  4BKX B;  4QA4 A;  5DC5 A;  5LI3 A;  5HJ9 A;  3Q9E A;  4ZUO A;  4Q3R A;  3MMR A;  1RLA A;  3MJL A;  3DJ8 A;  3SKK A;  5G0Y A;  3EZP A;  4QA7 A;  4CQF A;  1P8R A;  4A69 A;  4MYF A;  5THV A;  4QA6 A;  1T4S A;  3SFH A;  2VQO A;  5G0J A;  5DC6 A;  5DC7 A;  1ZPE A;  4RHK A;  1P8S A;  3E9B A;  3SFF A;  4MYN A;  4Q3U A;  4CBT A;  1TBL A;  5FUE A;  4Q41 A;  5IWG A;  2GH6 A;  5EFK B;  1P8M A;  3ZNR A;  3SJT A;  3E6K A;  4QA1 A;  3E8Z A;  1C3S A;  1R1O A;  3GN0 A;  3E8Q A;  5G0X A;  3SL1 A;  1T67 A;  2PLL A;  3EWF A;  4GSV A;  5EFB D;  2V5X A;  1PQ3 A;  5RLA A;  2VQW G;  4QA3 A;  4GWC A;  5HJA A;  1T64 A; 
#chains in the Genus database with same CATH homology
 4RHM A;  1HQX A;  1T4T A;  4GSM A;  1WVA A;  4RHJ A;  2PHA A;  3TH7 A;  2RLA A;  3RLA A;  1WOG A;  3LHL A;  3THJ A;  2A0M A;  3PZL A;  1D3V A;  4IE3 A;  4Q42 A;  3THE A;  4IE1 A;  3KV2 A;  3THH A;  4Q3Q A;  1T5F A;  1T4R A;  4RHI A;  4IU5 A;  1HQ5 A;  4HXQ A;  3MFV A;  4RHL A;  1T4P A;  4ITY A;  4Q40 A;  1HQG A;  5CEV A;  4MYK A;  3M1R A;  4MXR A;  1TBH A;  3NIQ A;  4IXU A;  4IU0 A;  1HQH A;  4RLA A;  4IU4 A;  1TA1 A;  3LP7 A;  1TBJ A;  4CEV A;  1P8P A;  4GSZ A;  4FCI A;  2AEB A;  2CEV A;  1GQ7 A;  1WOI A;  1WOH A;  3E6V A;  3TF3 A;  4Q3P A;  2ZAV A;  3MFW A;  4Q3S A;  1WVB A;  3NIO A;  4RHQ A;  1P8Q A;  4Q3V A;  3GMZ A;  4DZ4 A;  3F80 A;  4IXV A;  3SL0 A;  4Q3T A;  4G3H A;  1P8O A;  1XFK A;  2EF5 A;  4HWW A;  1P8N A;  2EF4 A;  4GWD A;  2EIV A;  4IE2 A;  4HZE A;  1HQF A;  4MYL A;  3CEV A;  1CEV A;  4IU1 A;  1ZPG A;  1T5G A;  4Q3R C;  4I06 A;  3NIP A;  1GQ6 A;  4FCK A;  2PHO A;  5HJ9 A;  4Q3R A;  3MMR A;  1RLA A;  3MJL A;  3DJ8 A;  3SKK A;  1P8R A;  4MYF A;  1T4S A;  1ZPE A;  4RHK A;  1P8S A;  3E9B A;  4Q41 A;  4MYN A;  4Q3U A;  5HJA A;  1TBL A;  1P8M A;  3SJT A;  3E6K A;  3E8Z A;  1R1O A;  3GN0 A;  3E8Q A;  3SL1 A;  2PLL A;  4GSV A;  1PQ3 A;  5RLA A;  4GWC A;  3LP4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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